MS4A14 Gene
protein-coding GIFtS: 43
GCID: GC11P060163
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|
membrane-spanning 4-domains, subfamily A, member 14(Previous names: membrane-spanning 4-domains, subfamily A, member 16 )
(Previous symbol: MS4A16)
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Aliases
for MS4A14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Membrane-Spanning 4-Domains, Subfamily A, Member 141 2 | | FLJ328561 | | MS4A161 2 3 | | Membrane-Spanning 4-Domains Subfamily A Member 142 | | NYD-SP211 2 | | MS4A13 Protein2 | | Membrane-Spanning 4-Domains, Subfamily A, Member 161 2 | | Testes Development-Related NYD-SP212 | | Testis Development Protein NYD-SP212 3 | | MS4A133 | | DKFZp434H0921 | | |
Export aliases for MS4A14 gene to outside databasesPrevious GC identifers: GC11P059922 GC11P056510 |
Summaries
for MS4A14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: M4A14_HUMAN, Q96JA4Function: May be involved in signal transduction as a component of a multimeric receptor complex (By similarity)
|
Genomic Views
for MS4A14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MS4A14 gene promoter:
CUTL1 GATA-1 Meis-1b SRY FOXO1a STAT3 Meis-1a ATF6 FOXO1 Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MS4A14
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MS4A14 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q12.2 Ensembl cytogenetic band: 11q12.2 HGNC cytogenetic band: 11q12.2MS4A14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P060163: view genomic region
(about GC identifiers)
Start:
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60,146,003 bp from pter |
End:
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60,185,229 bp from pter |
Size:
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39,227 bases |
Orientation:
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plus strand |
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Proteins
for MS4A14 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: M4A14_HUMAN, Q96JA4 (See
protein sequence)Recommended Name: Membrane-spanning 4-domains subfamily A member 14 Size: 679 amino acids; 76580 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q2TVT5 Q3B7W3 Q86XH8 Q9NTC2Alternative splicing: 3 isoforms: Q96JA4-1 Q96JA4-2 Q96JA4-4 Explore the universe of human proteins at neXtProt for MS4A14: NX_Q96JA4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96JA4
MS4A14 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001073160.1 NP_001248756.1 NP_001248757.1 NP_115986.3
ENSEMBL proteins: ENSP00000437222 ENSP00000300187 ENSP00000378453 ENSP00000435764 ENSP00000437003 ENSP00000434649 ENSP00000434271 ENSP00000433761 ENSP00000432323 ENSP00000433014 ENSP00000378449
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
MS4A14 for ontologies About GeneDecksing
MS4A14 Antibody Products:
Assay Products for MS4A14: |
Protein
Domains /
Families
for MS4A14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MS4A14 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96JA4ProtoNet protein and cluster: Q96JA4 1 Blocks protein family: IPB007237 CD20/IgE Fc receptor beta subunit
UniProtKB/Swiss-Prot: M4A14_HUMAN, Q96JA4Similarity: Belongs to the MS4A family |
Function
for MS4A14 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: M4A14_HUMAN, Q96JA4Function: May be involved in signal transduction as a component of a multimeric receptor complex (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MS4A14 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MS4A14 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MS4A14 (NM_032597) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MS4A14 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MS4A14 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A14 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
-- | -- |
MS4A14 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Ms4a14tm1Lex for MS4A14
1 MGI phenotypic allele  for Ms4a14 (no phenotypes)
MS4A14 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MS4A14 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MS4A14
|
Drugs & Compounds
for MS4A14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MS4A14
Search CenterWatch for drugs/clinical trials and news about MS4A14 / M4A14
|
Transcripts
for MS4A14 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MS4A14 gene (4 alternative transcripts): NM_001079692.2 NM_001261827.1 NM_001261828.1 NM_032597.4 Unigene Cluster for MS4A14: Membrane-spanning 4-domains, subfamily A, member 14 Hs.709736 [show with all ESTs]Unigene Representative Sequence: NR_04973411 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000531787(uc001npi.3) ENST00000300187(uc001npn.3 uc001npj.3 uc001npk.3 uc001npl.3)
ENST00000395005 ENST00000526375 ENST00000530662(uc001npm.3) ENST00000527841
ENST00000525397 ENST00000531783 ENST00000531949 ENST00000534688 ENST00000395001
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MS4A14 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MS4A14 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MS4A14 (NM_032597) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MS4A14 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MS4A14 |
Additional cDNA sequence: AF367473.2 AK057418.1 AK314674.1 AL137391.1 AY094610.1 AY094611.1 AY584610.1 BC035361.1 BC064627.1 BC107431.1 BC121039.1 BC121040.1 NR_049731.1 NR_049732.1 NR_049733.1 NR_049734.1 7 DOTS entries: DT.97811057 DT.310449 DT.100779018 DT.120730412 DT.120730400 DT.120730421 DT.95159364 24/241 AceView cDNA sequences (see all 241): AW817429 AK075106 BU626565 AW628301 AI672667 CA449361 AA704742 BQ029271 AL137391 AA287646 BF436405 CA413880 BX094854 AI076667 BC043485 AK057418 BX480789 NM_021201 BX115423 BQ027295 CA415166 AA701622 BQ029877 AL597914
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MS4A14 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e |
|---|
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| SP1: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for MS4A14
|
Expression
for MS4A14 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MS4A14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAGCACTC
About this image
See MS4A14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MS4A14
SOURCE GeneReport for Unigene cluster: Hs.709736
SABiosciences Custom PCR Arrays for MS4A14
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MS4A14
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MS4A14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MS4A14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MS4A14 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A14 |
Orthologs
for MS4A14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MS4A14 gene from 2/9 species (see all 9) About this table
ENSEMBL Gene Tree for MS4A14 (if available)
TreeFam Gene Tree for MS4A14 (if available) |
Paralogs
for MS4A14 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MS4A14 gene
- MS4A52
2 SIMAP similar genes for MS4A14 using alignment to 8 protein entries: M4A14_HUMAN (see all proteins):MS4A5 MS4A8B
MS4A14 for paralogs About GeneDecksing
|
Genomic Variants
for MS4A14 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MS4A14 (60146003 - 60185229 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MS4A14: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MS4A14 |
|
Disorders
/ Diseases
for MS4A14 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MS4A14 for disorders About GeneDecksing
2  diseases for MS4A14: About MalaCardshepatitis b hepatitis
Human Genome Epidemiology (HuGE) Navigator: MS4A14 (1 document)
Export disorders for MS4A14 gene to outside databases
|
Publications
for MS4A14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MS4A14 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MS4A14) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for MS4A14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MS4A14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MS4A14 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MS4A14 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MS4A14 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MS4A14 gene:
Search GeneIP for patents involving MS4A14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MS4A14 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MS4A14 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MS4A14 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MS4A14 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MS4A14 | | OriGene 3'-UTR Clone for MS4A14 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MS4A14 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MS4A14 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MS4A14 | | OriGene Custom Protein Services for MS4A14 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MS4A14 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MS4A14 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MS4A14 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MS4A14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MS4A14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MS4A14 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MS4A14 |
| |  |  |  |  | | | | |
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 | | | MS4A14 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A14 |
|  |  |  | | | | Search ThermoFisher Antibodies for MS4A14 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MS4A14 |
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