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Aliases for MS4A14 Gene

Aliases for MS4A14 Gene

  • Membrane Spanning 4-Domains A14 2 3
  • Membrane-Spanning 4-Domains, Subfamily A, Member 14 2 3 5
  • Membrane-Spanning 4-Domains, Subfamily A, Member 16 2 3
  • Testis Development Protein NYD-SP21 3 4
  • MS4A16 3 4
  • Testes Development-Related NYD-SP21 3
  • MS4A13 Protein 3
  • NYD-SP21 3
  • MS4A13 4

External Ids for MS4A14 Gene

Previous HGNC Symbols for MS4A14 Gene

  • MS4A16

Previous GeneCards Identifiers for MS4A14 Gene

  • GC11P059922
  • GC11P060163
  • GC11P056510

Summaries for MS4A14 Gene

GeneCards Summary for MS4A14 Gene

MS4A14 (Membrane Spanning 4-Domains A14) is a Protein Coding gene. An important paralog of this gene is MS4A5.

UniProtKB/Swiss-Prot for MS4A14 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A14 Gene

Genomics for MS4A14 Gene

Regulatory Elements for MS4A14 Gene

Enhancers for MS4A14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MS4A14 on UCSC Golden Path with GeneCards custom track

Promoters for MS4A14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MS4A14 on UCSC Golden Path with GeneCards custom track

Genomic Location for MS4A14 Gene

60,378,530 bp from pter
60,417,756 bp from pter
39,227 bases
Plus strand

Genomic View for MS4A14 Gene

Genes around MS4A14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A14 Gene

Proteins for MS4A14 Gene

  • Protein details for MS4A14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 14
    Protein Accession:
    Secondary Accessions:
    • E9PJE3
    • Q2TVT5
    • Q3B7W3
    • Q86XH8
    • Q9NTC2

    Protein attributes for MS4A14 Gene

    679 amino acids
    Molecular mass:
    76580 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MS4A14 Gene


neXtProt entry for MS4A14 Gene

Proteomics data for MS4A14 Gene at MOPED

Post-translational modifications for MS4A14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MS4A14 Gene

Domains & Families for MS4A14 Gene

Gene Families for MS4A14 Gene

Protein Domains for MS4A14 Gene

Suggested Antigen Peptide Sequences for MS4A14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A14: view

Function for MS4A14 Gene

Molecular function for MS4A14 Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.
genes like me logo Genes that share phenotypes with MS4A14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MS4A14

miRNA for MS4A14 Gene

miRTarBase miRNAs that target MS4A14

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A14 Gene

Localization for MS4A14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A14 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MS4A14 Gene COMPARTMENTS Subcellular localization image for MS4A14 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MS4A14 Gene

Pathways & Interactions for MS4A14 Gene

SuperPathways for MS4A14 Gene

No Data Available

Interacting Proteins for MS4A14 Gene

Gene Ontology (GO) - Biological Process for MS4A14 Gene


No data available for Pathways by source and SIGNOR curated interactions for MS4A14 Gene

Drugs & Compounds for MS4A14 Gene

No Compound Related Data Available

Transcripts for MS4A14 Gene

Unigene Clusters for MS4A14 Gene

Membrane-spanning 4-domains, subfamily A, member 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A14 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - - - -

Relevant External Links for MS4A14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A14 Gene

mRNA expression in normal human tissues for MS4A14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A14 Gene

This gene is overexpressed in Testis (x20.8).

Protein differential expression in normal tissues from HIPED for MS4A14 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MS4A14 Gene

SOURCE GeneReport for Unigene cluster for MS4A14 Gene Hs.709736

genes like me logo Genes that share expression patterns with MS4A14: view

Protein tissue co-expression partners for MS4A14 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MS4A14 Gene

Orthologs for MS4A14 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MS4A14 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MS4A14 35
  • 69.8 (n)
  • 52.07 (a)
MS4A14 36
  • 36 (a)
(Canis familiaris)
Mammalia MS4A14 35
  • 73.9 (n)
  • 55.2 (a)
MS4A14 36
  • 34 (a)
(Monodelphis domestica)
Mammalia MS4A14 36
  • 29 (a)
(Pan troglodytes)
Mammalia MS4A14 36
  • 97 (a)
Species with no ortholog for MS4A14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A14 Gene

Gene Tree for MS4A14 (if available)
Gene Tree for MS4A14 (if available)

Paralogs for MS4A14 Gene

Paralogs for MS4A14 Gene

(2) SIMAP similar genes for MS4A14 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with MS4A14: view

Variants for MS4A14 Gene

Sequence variations from dbSNP and Humsavar for MS4A14 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7131283 - 60,415,497(+) AAGAA(A/T)ATGAT nc-transcript-variant, reference, missense
rs3825020 - 60,416,718(-) TTGTC(C/T)ATCTT nc-transcript-variant, reference, missense
rs955017 -- 60,406,445(-) AGTGA(A/C)TGACA intron-variant
rs955018 -- 60,406,674(-) AAAGA(A/G)AGAGC intron-variant
rs955019 -- 60,406,777(-) TTCCG(A/G)GATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A14 Gene

Variant ID Type Subtype PubMed ID
esv2744569 CNV Deletion 23290073
esv2215205 CNV Deletion 18987734

Variation tolerance for MS4A14 Gene

Residual Variation Intolerance Score: 93.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.00; 80.04% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MS4A14 Gene

Disorders for MS4A14 Gene

Relevant External Links for MS4A14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MS4A14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A14 Gene

Publications for MS4A14 Gene

  1. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 3 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MS4A14 Gene

Sources for MS4A14 Gene