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Aliases for MS4A13 Gene

Aliases for MS4A13 Gene

  • Membrane Spanning 4-Domains A13 2 3 5
  • Membrane-Spanning 4-Domains, Subfamily A, Member 13 2
  • Testis-Expressed Transmembrane Protein 4 4

External Ids for MS4A13 Gene

Previous GeneCards Identifiers for MS4A13 Gene

  • GC00U921632
  • GC11U900699
  • GC11P060039
  • GC11P060282
  • GC11P056629

Summaries for MS4A13 Gene

GeneCards Summary for MS4A13 Gene

MS4A13 (Membrane Spanning 4-Domains A13) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MS4A13 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A13 Gene

Genomics for MS4A13 Gene

Regulatory Elements for MS4A13 Gene

Enhancers for MS4A13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G060366 1.4 FANTOM5 ENCODE dbSUPER 10.2 -147.9 -147898 1.7 TBL1XR1 EBF1 RELA ARID3A CBX5 EED ZNF143 RELB IKZF2 MAZ MS4A14 MS4A7 MS4A6E MS4A5 MS4A12 MS4A4A MS4A13 MS4A18 MS4A6A GC11P060374
GH11G060445 1.2 Ensembl ENCODE dbSUPER 10 -68.8 -68758 1.6 HDGF PKNOX1 IRF2 TRIM22 JUNB GATA2 POLR2A IKZF1 ZNF512 NBN MS4A1 MS4A12 MS4A13 MS4A6E MS4A18 MS4A7 MS4A5
GH11G060370 1 ENCODE dbSUPER 10.2 -144.3 -144305 1.5 TFAP4 PKNOX1 FOXA2 JUN FOSL1 CTBP1 GATA3 ZNF366 FOSL2 FOS MS4A14 MS4A5 MS4A13 MS4A7 GC11P060374 MS4A6E
GH11G060486 0.8 ENCODE 10.9 -29.3 -29264 0.2 CTCF PKNOX1 MXI1 TBL1XR1 RB1 WRNIP1 ZNF384 RAD21 RELA RFX5 MS4A1 MS4A13 MS4A6E MS4A14 MS4A7 MS4A18 MS4A12
GH11G060481 0.7 dbSUPER 10.9 -32.3 -32324 4.1 BCOR CTCF ZNF146 ZBTB11 TRIM22 REST RAD21 ZBTB40 CHAMP1 GABPA MS4A1 MS4A12 MS4A7 MS4A13 MS4A6E MS4A14 MS4A18 MS4A8
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MS4A13 on UCSC Golden Path with GeneCards custom track

Genomic Location for MS4A13 Gene

60,515,376 bp from pter
60,543,424 bp from pter
28,049 bases
Plus strand

Genomic View for MS4A13 Gene

Genes around MS4A13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A13 Gene

Proteins for MS4A13 Gene

  • Protein details for MS4A13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 13
    Protein Accession:
    Secondary Accessions:
    • B2RTS9
    • Q5J8X3
    • Q5J8X4

    Protein attributes for MS4A13 Gene

    152 amino acids
    Molecular mass:
    17307 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MS4A13 Gene


neXtProt entry for MS4A13 Gene

Post-translational modifications for MS4A13 Gene

No Post-translational modifications

Other Protein References for MS4A13 Gene

No data available for DME Specific Peptides for MS4A13 Gene

Domains & Families for MS4A13 Gene

Gene Families for MS4A13 Gene

Protein Domains for MS4A13 Gene


Suggested Antigen Peptide Sequences for MS4A13 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A13: view

Function for MS4A13 Gene

Molecular function for MS4A13 Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.
genes like me logo Genes that share phenotypes with MS4A13: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MS4A13 Gene

Localization for MS4A13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A13 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MS4A13 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MS4A13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A13: view

Pathways & Interactions for MS4A13 Gene

SuperPathways for MS4A13 Gene

No Data Available

Interacting Proteins for MS4A13 Gene

Gene Ontology (GO) - Biological Process for MS4A13 Gene


No data available for Pathways by source and SIGNOR curated interactions for MS4A13 Gene

Drugs & Compounds for MS4A13 Gene

No Compound Related Data Available

Transcripts for MS4A13 Gene

mRNA/cDNA for MS4A13 Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MS4A13 Gene

Membrane-spanning 4-domains, subfamily A, member 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A13 Gene

No ASD Table

Relevant External Links for MS4A13 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MS4A13 Gene

mRNA differential expression in normal tissues according to GTEx for MS4A13 Gene

This gene is overexpressed in Testis (x53.0).

NURSA nuclear receptor signaling pathways regulating expression of MS4A13 Gene:


SOURCE GeneReport for Unigene cluster for MS4A13 Gene:

genes like me logo Genes that share expression patterns with MS4A13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for MS4A13 Gene

Orthologs for MS4A13 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MS4A13 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MS4A13 34 35
  • 98.68 (n)
(Canis familiaris)
Mammalia LOC100685813 34
  • 80.79 (n)
MS4A13 35
  • 61 (a)
(Bos Taurus)
Mammalia MS4A13 34 35
  • 77.92 (n)
(Mus musculus)
Mammalia Ms4a13 34 16 35
  • 74.88 (n)
(Rattus norvegicus)
Mammalia Ms4a13-ps1 34
  • 73.33 (n)
(Monodelphis domestica)
Mammalia MS4A13 35
  • 12 (a)
Species where no ortholog for MS4A13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A13 Gene

Gene Tree for MS4A13 (if available)
Gene Tree for MS4A13 (if available)

Paralogs for MS4A13 Gene

No data available for Paralogs for MS4A13 Gene

Variants for MS4A13 Gene

Sequence variations from dbSNP and Humsavar for MS4A13 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000027153 -- 60,521,365(+) TAAAT(C/T)TTTTT intron-variant
rs1000102863 -- 60,532,256(+) TCTGA(A/G/T)GTACC intron-variant
rs1000142860 -- 60,521,596(+) CTTCC(A/G)TCTGA intron-variant
rs1000172393 -- 60,538,871(+) GGGTT(G/T)AATGC intron-variant
rs1000492725 -- 60,513,891(+) TAAAG(C/G/T)GAATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MS4A13 Gene

Variant ID Type Subtype PubMed ID
esv3303207 CNV mobile element insertion 20981092
esv3309595 CNV mobile element insertion 20981092
nsv337 CNV insertion 18451855
nsv555152 CNV loss 21841781

Variation tolerance for MS4A13 Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 30.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MS4A13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A13 Gene

Disorders for MS4A13 Gene

Relevant External Links for MS4A13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MS4A13 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A13 Gene

Publications for MS4A13 Gene

  1. Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. (PMID: 23934736) Yu B. … Boerwinkle E. (Genet. Epidemiol. 2013) 3 64
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for MS4A13 Gene

Sources for MS4A13 Gene

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