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Aliases for MS4A12 Gene

Aliases for MS4A12 Gene

  • Membrane-Spanning 4-Domains, Subfamily A, Member 12 2 3
  • Membrane-Spanning 4-Domains Subfamily A Member 12 3
  • Ms4a10 3

External Ids for MS4A12 Gene

Previous GeneCards Identifiers for MS4A12 Gene

  • GC11P062654
  • GC11P061773
  • GC11P060035
  • GC11P060016
  • GC11P060260
  • GC11P056606

Summaries for MS4A12 Gene

Entrez Gene Summary for MS4A12 Gene

  • The protein encoded by this gene is a cell surface protein found primarily in the apical membrane of colonocytes. Silencing of this gene in colon cancer cells inhibits the proliferation, cell motility, and chemotactic invasion of cells. This gene is part of a cluster of similar genes found on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for MS4A12 Gene

MS4A12 (Membrane-Spanning 4-Domains, Subfamily A, Member 12) is a Protein Coding gene. An important paralog of this gene is MS4A18.

UniProtKB/Swiss-Prot for MS4A12 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A12 Gene

Genomics for MS4A12 Gene

Regulatory Elements for MS4A12 Gene

Genomic Location for MS4A12 Gene

60,492,713 bp from pter
60,507,430 bp from pter
14,718 bases
Plus strand

Genomic View for MS4A12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MS4A12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A12 Gene

Proteins for MS4A12 Gene

  • Protein details for MS4A12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 12
    Protein Accession:
    Secondary Accessions:
    • F5GX98
    • Q8N6L4

    Protein attributes for MS4A12 Gene

    267 amino acids
    Molecular mass:
    28069 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MS4A12 Gene


neXtProt entry for MS4A12 Gene

Proteomics data for MS4A12 Gene at MOPED

Post-translational modifications for MS4A12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MS4A12 Gene

No data available for DME Specific Peptides for MS4A12 Gene

Domains for MS4A12 Gene

Protein Domains for MS4A12 Gene


Suggested Antigen Peptide Sequences for MS4A12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9NXJ0
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A12: view

No data available for Gene Families for MS4A12 Gene

Function for MS4A12 Gene

Molecular function for MS4A12 Gene

UniProtKB/Swiss-Prot Function: May be involved in signal transduction as a component of a multimeric receptor complex

Gene Ontology (GO) - Molecular Function for MS4A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0015279 store-operated calcium channel activity IEA --
genes like me logo Genes that share ontologies with MS4A12: view

Phenotypes for MS4A12 Gene

GenomeRNAi human phenotypes for MS4A12:
genes like me logo Genes that share phenotypes with MS4A12: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MS4A12 Gene

Localization for MS4A12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A12 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MS4A12 Gene COMPARTMENTS Subcellular localization image for MS4A12 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MS4A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A12: view

Pathways for MS4A12 Gene

SuperPathways for MS4A12 Gene

No Data Available

Interacting Proteins for MS4A12 Gene

Gene Ontology (GO) - Biological Process for MS4A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070588 calcium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with MS4A12: view

No data available for Pathways by source for MS4A12 Gene

Transcripts for MS4A12 Gene

mRNA/cDNA for MS4A12 Gene

(7) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MS4A12 Gene

Membrane-spanning 4-domains, subfamily A, member 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A12 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: - - -

Relevant External Links for MS4A12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A12 Gene

mRNA expression in normal human tissues for MS4A12 Gene

mRNA differential expression in normal tissues according to GTEx for MS4A12 Gene

This gene is overexpressed in Colon - Transverse (51.2).

SOURCE GeneReport for Unigene cluster for MS4A12 Gene Hs.272789

genes like me logo Genes that share expressions with MS4A12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for MS4A12 Gene

Orthologs for MS4A12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MS4A12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MS4A12 35
  • 98.63 (n)
  • 96.63 (a)
MS4A12 36
  • 97 (a)
(Mus musculus)
Mammalia Ms4a12 35
  • 67.32 (n)
  • 53.33 (a)
(Monodelphis domestica)
Mammalia MS4A12 36
  • 35 (a)
(Rattus norvegicus)
Mammalia Ms4a12 35
  • 66.54 (n)
  • 53.31 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
-- 36
  • 37 (a)
-- 36
  • 32 (a)
(Danio rerio)
Actinopterygii FP015791.1 36
  • 26 (a)
ms4a17a.1 36
  • 25 (a)
ms4a17a.10 36
  • 24 (a)
ms4a17a.11 36
  • 27 (a)
ms4a17a.14 36
  • 28 (a)
ms4a17a.17 36
  • 22 (a)
ms4a17a.2 36
  • 22 (a)
ms4a17a.3 36
  • 22 (a)
ms4a17a.4 36
  • 24 (a)
ms4a17a.5 36
  • 25 (a)
ms4a17a.6 36
  • 26 (a)
ms4a17a.7 36
  • 24 (a)
ms4a17a.8 36
  • 24 (a)
ms4a17a.9 36
  • 24 (a)
ms4a17c.1 36
  • 28 (a)
ms4a17c.2 36
  • 24 (a)
si:ch73-56d11.3 36
  • 23 (a)
si:ch73-56d11.4 36
  • 25 (a)
si:dkey-174k12.3 36
  • 25 (a)
si:dkey-238j22.1 36
  • 27 (a)
si:dkey-77f5.10 36
  • 26 (a)
Species with no ortholog for MS4A12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MS4A12 Gene

Gene Tree for MS4A12 (if available)
Gene Tree for MS4A12 (if available)

Paralogs for MS4A12 Gene

Paralogs for MS4A12 Gene

Selected SIMAP similar genes for MS4A12 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MS4A12: view

Variants for MS4A12 Gene

Sequence variations from dbSNP and Humsavar for MS4A12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1941018 -- 60,501,521(+) AGAGA(A/G)AGAAA intron-variant
rs1941019 -- 60,501,591(+) TGATT(G/T)TAGTC intron-variant
rs1941020 -- 60,505,098(+) atacc(A/C)aagac intron-variant
rs1941021 -- 60,505,288(+) TCACT(A/G)TCACA intron-variant
rs1941022 -- 60,505,414(+) aaacc(A/G)tatca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A12 Gene

Variant ID Type Subtype PubMed ID
nsv337 CNV Insertion 18451855

Relevant External Links for MS4A12 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A12 Gene

Disorders for MS4A12 Gene

No disorders were found for MS4A12 Gene.

No data available for UniProtKB/Swiss-Prot for MS4A12 Gene

Publications for MS4A12 Gene

  1. Structural organization of the human MS4A gene cluster on chromosome 11q12. (PMID: 11486273) Liang Y. … Tedder T.F. (Immunogenetics 2001) 2 3 23
  2. Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PMID: 11401424) Liang Y. … Tedder T.F. (Genomics 2001) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for MS4A12 Gene

Sources for MS4A12 Gene

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