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Aliases for MS4A12 Gene

Aliases for MS4A12 Gene

  • Membrane Spanning 4-Domains A12 2 3 5
  • Membrane-Spanning 4-Domains, Subfamily A, Member 12 2
  • Membrane-Spanning 4-Domains Subfamily A Member 12 3
  • Ms4a10 3

External Ids for MS4A12 Gene

Previous GeneCards Identifiers for MS4A12 Gene

  • GC11P062654
  • GC11P061773
  • GC11P060035
  • GC11P060016
  • GC11P060260
  • GC11P056606

Summaries for MS4A12 Gene

Entrez Gene Summary for MS4A12 Gene

  • The protein encoded by this gene is a cell surface protein found primarily in the apical membrane of colonocytes. Silencing of this gene in colon cancer cells inhibits the proliferation, cell motility, and chemotactic invasion of cells. This gene is part of a cluster of similar genes found on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for MS4A12 Gene

MS4A12 (Membrane Spanning 4-Domains A12) is a Protein Coding gene. GO annotations related to this gene include store-operated calcium channel activity. An important paralog of this gene is MS4A8.

UniProtKB/Swiss-Prot for MS4A12 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A12 Gene

Genomics for MS4A12 Gene

Regulatory Elements for MS4A12 Gene

Enhancers for MS4A12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F060498 1.1 Ensembl ENCODE 21.1 +7.0 6967 3.4 CTCF PKNOX1 ZNF654 TEAD4 TRIM22 REST EBF1 TBX21 RAD21 ZNF143 MS4A12 MS4A14 LOC105369320
GH11F060362 1.4 FANTOM5 Ensembl ENCODE 10.9 -128.5 -128542 3.2 PKNOX1 RAD21 CHAMP1 ZNF143 THAP11 ZNF654 ZBTB11 ZEB2 REST ZNF589 MS4A14 MS4A7 MS4A6E MS4A5 MS4A12 MS4A18 MS4A6A MS4A4A GC11P060374
GH11F060366 1.2 FANTOM5 Ensembl ENCODE 10.9 -125.3 -125264 1.7 MAZ TBL1XR1 MTA2 BHLHE40 EBF1 TBX21 EP300 RELA CBX5 ZNF585B MS4A14 MS4A7 MS4A6E MS4A5 MS4A12 MS4A4A MS4A13 MS4A18 MS4A6A GC11P060374
GH11F060445 0.9 Ensembl ENCODE 10.3 -46.1 -46141 1.6 HDGF PKNOX1 IRF2 JUNB TRIM22 POLR2A ZNF512 IKZF1 NBN IRF1 MS4A1 MS4A12 MS4A13 MS4A6E MS4A18 MS4A7 MS4A5
GH11F060310 1 Ensembl ENCODE 10.2 -182.0 -181995 1.1 PKNOX1 MXI1 CBX3 BMI1 CBX5 EED TRIM24 CREM MAFK CHD2 MS4A6E MS4A12 MS4A18 GC11M060301
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MS4A12 on UCSC Golden Path with GeneCards custom track

Genomic Location for MS4A12 Gene

60,492,742 bp from pter
60,507,430 bp from pter
14,689 bases
Plus strand

Genomic View for MS4A12 Gene

Genes around MS4A12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A12 Gene

Proteins for MS4A12 Gene

  • Protein details for MS4A12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 12
    Protein Accession:
    Secondary Accessions:
    • F5GX98
    • Q8N6L4

    Protein attributes for MS4A12 Gene

    267 amino acids
    Molecular mass:
    28069 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MS4A12 Gene


neXtProt entry for MS4A12 Gene

Post-translational modifications for MS4A12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MS4A12 Gene

No data available for DME Specific Peptides for MS4A12 Gene

Domains & Families for MS4A12 Gene

Gene Families for MS4A12 Gene

Protein Domains for MS4A12 Gene


Suggested Antigen Peptide Sequences for MS4A12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A12: view

Function for MS4A12 Gene

Molecular function for MS4A12 Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.

Gene Ontology (GO) - Molecular Function for MS4A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MS4A12: view

Phenotypes for MS4A12 Gene

genes like me logo Genes that share phenotypes with MS4A12: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MS4A12 Gene

Localization for MS4A12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A12 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MS4A12 Gene COMPARTMENTS Subcellular localization image for MS4A12 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for MS4A12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A12: view

Pathways & Interactions for MS4A12 Gene

SuperPathways for MS4A12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MS4A12 Gene


No data available for Pathways by source and SIGNOR curated interactions for MS4A12 Gene

Transcripts for MS4A12 Gene

mRNA/cDNA for MS4A12 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MS4A12 Gene

Membrane-spanning 4-domains, subfamily A, member 12:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A12 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: - - -

Relevant External Links for MS4A12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MS4A12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A12 Gene

This gene is overexpressed in Colon - Transverse (x51.2).

NURSA nuclear receptor signaling pathways regulating expression of MS4A12 Gene:


SOURCE GeneReport for Unigene cluster for MS4A12 Gene:

genes like me logo Genes that share expression patterns with MS4A12: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MS4A12 Gene

Orthologs for MS4A12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MS4A12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MS4A12 34 35
  • 98.63 (n)
(Mus musculus)
Mammalia Ms4a12 34 16
  • 67.32 (n)
(Rattus norvegicus)
Mammalia Ms4a12 34
  • 66.54 (n)
(Monodelphis domestica)
Mammalia MS4A12 35
  • 35 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 37 (a)
-- 35
  • 32 (a)
-- 35
  • 32 (a)
(Danio rerio)
Actinopterygii ms4a17a.14 35
  • 28 (a)
ms4a17c.1 35
  • 28 (a)
ms4a17a.11 35
  • 27 (a)
si:dkey-238j22.1 35
  • 27 (a)
FP015791.1 35
  • 26 (a)
ms4a17a.6 35
  • 26 (a)
si:dkey-77f5.10 35
  • 26 (a)
ms4a17a.1 35
  • 25 (a)
ms4a17a.5 35
  • 25 (a)
si:ch73-56d11.4 35
  • 25 (a)
si:dkey-174k12.3 35
  • 25 (a)
ms4a17a.10 35
  • 24 (a)
ms4a17a.4 35
  • 24 (a)
ms4a17a.7 35
  • 24 (a)
ms4a17a.8 35
  • 24 (a)
ms4a17a.9 35
  • 24 (a)
ms4a17c.2 35
  • 24 (a)
si:ch73-56d11.3 35
  • 23 (a)
ms4a17a.17 35
  • 22 (a)
ms4a17a.2 35
  • 22 (a)
ms4a17a.3 35
  • 22 (a)
Species where no ortholog for MS4A12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MS4A12 Gene

Gene Tree for MS4A12 (if available)
Gene Tree for MS4A12 (if available)

Paralogs for MS4A12 Gene

Paralogs for MS4A12 Gene

(4) SIMAP similar genes for MS4A12 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MS4A12: view

Variants for MS4A12 Gene

Sequence variations from dbSNP and Humsavar for MS4A12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10792279 -- 60,498,874(+) TGTCT(G/T)TGAGG intron-variant
rs10792280 -- 60,498,935(+) GAGGG(A/G)GCAGT intron-variant
rs10792281 -- 60,499,036(+) CTGAA(G/T)CATGC intron-variant
rs111546873 -- 60,502,032(+) TTCCC(A/G)TTGTC reference, missense
rs111889425 -- 60,507,681(+) TCATC(G/T)ACAAA downstream-variant-500B, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MS4A12 Gene

Variant ID Type Subtype PubMed ID
nsv337 CNV insertion 18451855

Variation tolerance for MS4A12 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.99; 98.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MS4A12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A12 Gene

Disorders for MS4A12 Gene

Relevant External Links for MS4A12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MS4A12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A12 Gene

Publications for MS4A12 Gene

  1. Structural organization of the human MS4A gene cluster on chromosome 11q12. (PMID: 11486273) Liang Y. … Tedder T.F. (Immunogenetics 2001) 2 3 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PMID: 11401424) Liang Y. … Tedder T.F. (Genomics 2001) 2 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for MS4A12 Gene

Sources for MS4A12 Gene

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