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Aliases for MS4A12 Gene

Aliases for MS4A12 Gene

  • Membrane Spanning 4-Domains A12 2 3
  • Membrane-Spanning 4-Domains, Subfamily A, Member 12 2 3 5
  • Ms4a10 3

External Ids for MS4A12 Gene

Previous GeneCards Identifiers for MS4A12 Gene

  • GC11P062654
  • GC11P061773
  • GC11P060035
  • GC11P060016
  • GC11P060260
  • GC11P056606

Summaries for MS4A12 Gene

Entrez Gene Summary for MS4A12 Gene

  • The protein encoded by this gene is a cell surface protein found primarily in the apical membrane of colonocytes. Silencing of this gene in colon cancer cells inhibits the proliferation, cell motility, and chemotactic invasion of cells. This gene is part of a cluster of similar genes found on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for MS4A12 Gene

MS4A12 (Membrane Spanning 4-Domains A12) is a Protein Coding gene. GO annotations related to this gene include store-operated calcium channel activity. An important paralog of this gene is MS4A8.

UniProtKB/Swiss-Prot for MS4A12 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A12 Gene

Genomics for MS4A12 Gene

Regulatory Elements for MS4A12 Gene

Genomic Location for MS4A12 Gene

Chromosome:
11
Start:
60,492,742 bp from pter
End:
60,507,430 bp from pter
Size:
14,689 bases
Orientation:
Plus strand

Genomic View for MS4A12 Gene

Genes around MS4A12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A12 Gene

Proteins for MS4A12 Gene

  • Protein details for MS4A12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXJ0-M4A12_HUMAN
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 12
    Protein Accession:
    Q9NXJ0
    Secondary Accessions:
    • F5GX98
    • Q8N6L4

    Protein attributes for MS4A12 Gene

    Size:
    267 amino acids
    Molecular mass:
    28069 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MS4A12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MS4A12 Gene

Proteomics data for MS4A12 Gene at MOPED

Post-translational modifications for MS4A12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MS4A12 Gene

No data available for DME Specific Peptides for MS4A12 Gene

Domains & Families for MS4A12 Gene

Gene Families for MS4A12 Gene

Protein Domains for MS4A12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MS4A12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXJ0

UniProtKB/Swiss-Prot:

M4A12_HUMAN :
  • Belongs to the MS4A family.
Family:
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A12: view

Function for MS4A12 Gene

Molecular function for MS4A12 Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.

Phenotypes for MS4A12 Gene

genes like me logo Genes that share phenotypes with MS4A12: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MS4A12 Gene

Localization for MS4A12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A12 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MS4A12 Gene COMPARTMENTS Subcellular localization image for MS4A12 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for MS4A12 Gene

Pathways & Interactions for MS4A12 Gene

SuperPathways for MS4A12 Gene

No Data Available

Interacting Proteins for MS4A12 Gene

Gene Ontology (GO) - Biological Process for MS4A12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MS4A12 Gene

Drugs & Compounds for MS4A12 Gene

No Compound Related Data Available

Transcripts for MS4A12 Gene

mRNA/cDNA for MS4A12 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MS4A12 Gene

Membrane-spanning 4-domains, subfamily A, member 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A12 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: - - -
SP3:

Relevant External Links for MS4A12 Gene

GeneLoc Exon Structure for
MS4A12
ECgene alternative splicing isoforms for
MS4A12

Expression for MS4A12 Gene

mRNA expression in normal human tissues for MS4A12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A12 Gene

This gene is overexpressed in Colon - Transverse (x51.2).

SOURCE GeneReport for Unigene cluster for MS4A12 Gene Hs.272789

genes like me logo Genes that share expression patterns with MS4A12: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MS4A12 Gene

Orthologs for MS4A12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MS4A12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MS4A12 35
  • 98.63 (n)
  • 96.63 (a)
MS4A12 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ms4a12 35
  • 66.54 (n)
  • 53.31 (a)
oppossum
(Monodelphis domestica)
Mammalia MS4A12 36
  • 35 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ms4a12 16
Ms4a12 35
  • 67.32 (n)
  • 53.33 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii FP015791.1 36
  • 26 (a)
ManyToMany
ms4a17a.1 36
  • 25 (a)
ManyToMany
ms4a17a.10 36
  • 24 (a)
ManyToMany
ms4a17a.11 36
  • 27 (a)
ManyToMany
ms4a17a.14 36
  • 28 (a)
ManyToMany
ms4a17a.17 36
  • 22 (a)
ManyToMany
ms4a17a.2 36
  • 22 (a)
ManyToMany
ms4a17a.3 36
  • 22 (a)
ManyToMany
ms4a17a.4 36
  • 24 (a)
ManyToMany
ms4a17a.5 36
  • 25 (a)
ManyToMany
ms4a17a.6 36
  • 26 (a)
ManyToMany
ms4a17a.7 36
  • 24 (a)
ManyToMany
ms4a17a.8 36
  • 24 (a)
ManyToMany
ms4a17a.9 36
  • 24 (a)
ManyToMany
ms4a17c.1 36
  • 28 (a)
ManyToMany
ms4a17c.2 36
  • 24 (a)
ManyToMany
si:ch73-56d11.3 36
  • 23 (a)
ManyToMany
si:ch73-56d11.4 36
  • 25 (a)
ManyToMany
si:dkey-174k12.3 36
  • 25 (a)
ManyToMany
si:dkey-238j22.1 36
  • 27 (a)
ManyToMany
si:dkey-77f5.10 36
  • 26 (a)
ManyToMany
Species with no ortholog for MS4A12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MS4A12 Gene

ENSEMBL:
Gene Tree for MS4A12 (if available)
TreeFam:
Gene Tree for MS4A12 (if available)

Paralogs for MS4A12 Gene

Paralogs for MS4A12 Gene

(4) SIMAP similar genes for MS4A12 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MS4A12: view

Variants for MS4A12 Gene

Sequence variations from dbSNP and Humsavar for MS4A12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs12788393 - 60,497,347(+) CCATG(A/C)TGAAG reference, missense
rs1941018 -- 60,501,521(+) AGAGA(A/G)AGAAA intron-variant
rs1941019 -- 60,501,591(+) TGATT(G/T)TAGTC intron-variant
rs2155710 -- 60,501,767(+) AAACA(C/T)TGTGA intron-variant
rs2155711 -- 60,502,570(+) AAGAC(A/T)GGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A12 Gene

Variant ID Type Subtype PubMed ID
nsv337 CNV Insertion 18451855

Variation tolerance for MS4A12 Gene

Residual Variation Intolerance Score: 86.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.99; 98.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MS4A12 Gene

HapMap Linkage Disequilibrium report
MS4A12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A12 Gene

Disorders for MS4A12 Gene

Relevant External Links for MS4A12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MS4A12

No disorders were found for MS4A12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A12 Gene

Publications for MS4A12 Gene

  1. Structural organization of the human MS4A gene cluster on chromosome 11q12. (PMID: 11486273) Liang Y. … Tedder T.F. (Immunogenetics 2001) 2 3 23 67
  2. Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PMID: 11401424) Liang Y. … Tedder T.F. (Genomics 2001) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2. (PMID: 19781065) Koslowski M. … Sahin U. (Mol. Cancer 2009) 3
  5. MS4A12 is a colon-selective store-operated calcium channel promoting malignant cell processes. (PMID: 18451174) Koslowski M. … TA1reci O. (Cancer Res. 2008) 3

Products for MS4A12 Gene

Sources for MS4A12 Gene

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