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Aliases for MS4A10 Gene

Aliases for MS4A10 Gene

  • Membrane Spanning 4-Domains A10 2 3 5
  • Membrane-Spanning 4-Domains, Subfamily A, Member 10 2 3
  • CD20 Antigen-Like 7 3 4
  • CD20L7 3 4
  • MS4A9 3 4
  • Membrane-Spanning 4-Domains Subfamily A Member 10 3

External Ids for MS4A10 Gene

Previous GeneCards Identifiers for MS4A10 Gene

  • GC11P062951
  • GC11M062071
  • GC11P060333
  • GC11P060328
  • GC11P060309
  • GC11P060552
  • GC11P056899

Summaries for MS4A10 Gene

Entrez Gene Summary for MS4A10 Gene

  • Most MS4A genes, including MS4A10, encode proteins with at least 4 potential transmembrane domains and N- and C-terminal cytoplasmic domains encoded by distinct exons.[supplied by OMIM, Apr 2004]

GeneCards Summary for MS4A10 Gene

MS4A10 (Membrane Spanning 4-Domains A10) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MS4A10 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

Additional gene information for MS4A10 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A10 Gene

Genomics for MS4A10 Gene

Regulatory Elements for MS4A10 Gene

Enhancers for MS4A10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H060871 1.2 Ensembl ENCODE dbSUPER 10.6 +87.4 87376 2.7 HLF MAX REST RARA ZFP69B NFIC ZNF316 SMARCA4 FOS FOXP2 PRPF19 ENSG00000255959 CCDC86 ENSG00000257052 MS4A10 ENSG00000255845 PIR47747
GH11H060898 1 ENCODE dbSUPER 10.5 +114.2 114184 1.2 CTCF RAD21 ZNF316 POLR2A EED SMC3 ZNF143 NFE2 CREM MAFK ENSG00000255959 CCDC86 PTGDR2 ENSG00000256813 MS4A10 PRPF19 PIR47747
GH11H060763 0.9 ENCODE 11.4 -21.9 -21872 0.8 HDGF RB1 SIN3A BATF RAD21 ZNF143 ZNF207 ATF7 RUNX3 IKZF2 MS4A10 MS4A18 ENSG00000255959 CCDC86 MS4A8 MS4A15
GH11H060765 0.6 FANTOM5 11.5 -20.2 -20153 0.2 SRF POLR2A ELK1 ATF7 BATF ATF2 CREM MS4A10 TMEM109 MS4A8 ENSG00000255845 CCDC86 ENSG00000255959 MS4A1 MS4A13 MS4A15
GH11H060756 0.6 ENCODE 11.4 -28.5 -28522 0.2 MITF CTCF CBFB SMC3 RUNX3 RAD21 MS4A10 MS4A18 CCDC86 ENSG00000255959 MS4A15
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MS4A10 on UCSC Golden Path with GeneCards custom track

Genomic Locations for MS4A10 Gene

Genomic Locations for MS4A10 Gene
16,002 bases
Plus strand

Genomic View for MS4A10 Gene

Genes around MS4A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A10 Gene

Proteins for MS4A10 Gene

  • Protein details for MS4A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 10
    Protein Accession:
    Secondary Accessions:
    • B2RP45
    • Q96PG3

    Protein attributes for MS4A10 Gene

    267 amino acids
    Molecular mass:
    29747 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MS4A10 Gene

Post-translational modifications for MS4A10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MS4A10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MS4A10 Gene

Domains & Families for MS4A10 Gene

Gene Families for MS4A10 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for MS4A10 Gene

Suggested Antigen Peptide Sequences for MS4A10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A10: view

Function for MS4A10 Gene

Molecular function for MS4A10 Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.
genes like me logo Genes that share phenotypes with MS4A10: view

Animal Model Products

CRISPR Products

miRNA for MS4A10 Gene

miRTarBase miRNAs that target MS4A10

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A10 Gene

Localization for MS4A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MS4A10 gene
Compartment Confidence
plasma membrane 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MS4A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MS4A10 Gene

Pathways & Interactions for MS4A10 Gene

SuperPathways for MS4A10 Gene

No Data Available

Interacting Proteins for MS4A10 Gene

Selected Interacting proteins: Q96PG2-M4A10_HUMAN for MS4A10 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for MS4A10 Gene


No data available for Pathways by source and SIGNOR curated interactions for MS4A10 Gene

Drugs & Compounds for MS4A10 Gene

No Compound Related Data Available

Transcripts for MS4A10 Gene

mRNA/cDNA for MS4A10 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MS4A10 Gene

Membrane-spanning 4-domains, subfamily A, member 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A10 Gene

No ASD Table

Relevant External Links for MS4A10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MS4A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A10 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x50.9).

Protein differential expression in normal tissues from HIPED for MS4A10 Gene

This gene is overexpressed in Fetal Brain (62.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MS4A10 Gene

Protein tissue co-expression partners for MS4A10 Gene

NURSA nuclear receptor signaling pathways regulating expression of MS4A10 Gene:


SOURCE GeneReport for Unigene cluster for MS4A10 Gene:


Evidence on tissue expression from TISSUES for MS4A10 Gene

  • Intestine(4.3)
genes like me logo Genes that share expression patterns with MS4A10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MS4A10 Gene

Orthologs for MS4A10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MS4A10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MS4A10 33 34
  • 99.25 (n)
(Bos Taurus)
Mammalia MS4A10 34 33
  • 72.01 (n)
(Rattus norvegicus)
Mammalia Ms4a10 33
  • 68.63 (n)
(Mus musculus)
Mammalia Ms4a10 16 34 33
  • 66.52 (n)
(Canis familiaris)
Mammalia MS4A10 34
  • 62 (a)
Species where no ortholog for MS4A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A10 Gene

Gene Tree for MS4A10 (if available)
Gene Tree for MS4A10 (if available)

Paralogs for MS4A10 Gene

No data available for Paralogs for MS4A10 Gene

Variants for MS4A10 Gene

Sequence variations from dbSNP and Humsavar for MS4A10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000368961 -- 60,796,335(+) TGGAG(C/T)ACAGT intron-variant
rs1000579297 -- 60,797,446(+) ATCCC(A/T)TCCGG intron-variant
rs1000606901 -- 60,788,529(+) CCTCT(G/T)CCACC intron-variant
rs1000683550 -- 60,799,270(+) CCTAC(C/T)TGTGC intron-variant
rs1000744751 -- 60,794,315(+) AGTCC(A/G)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MS4A10 Gene

Variant ID Type Subtype PubMed ID
esv3366730 CNV insertion 20981092

Variation tolerance for MS4A10 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MS4A10 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A10 Gene

Disorders for MS4A10 Gene

Relevant External Links for MS4A10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MS4A10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A10 Gene

Publications for MS4A10 Gene

  1. Structural organization of the human MS4A gene cluster on Chromosome 11q12. (PMID: 11486273) Liang Y … Tedder TF (Immunogenetics 2001) 2 3 4 60
  2. Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PMID: 11401424) Liang Y … Tedder TF (Genomics 2001) 2 3 60
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60

Products for MS4A10 Gene

Sources for MS4A10 Gene

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