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Aliases for MS4A10 Gene

Aliases for MS4A10 Gene

  • Membrane Spanning 4-Domains A10 2 3 5
  • Membrane-Spanning 4-Domains, Subfamily A, Member 10 2 3
  • CD20 Antigen-Like 7 3 4
  • CD20L7 3 4
  • MS4A9 3 4
  • Membrane-Spanning 4-Domains Subfamily A Member 10 3

External Ids for MS4A10 Gene

Previous GeneCards Identifiers for MS4A10 Gene

  • GC11P062951
  • GC11M062071
  • GC11P060333
  • GC11P060328
  • GC11P060309
  • GC11P060552
  • GC11P056899

Summaries for MS4A10 Gene

Entrez Gene Summary for MS4A10 Gene

  • Most MS4A genes, including MS4A10, encode proteins with at least 4 potential transmembrane domains and N- and C-terminal cytoplasmic domains encoded by distinct exons.[supplied by OMIM, Apr 2004]

GeneCards Summary for MS4A10 Gene

MS4A10 (Membrane Spanning 4-Domains A10) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MS4A10 Gene

  • May be involved in signal transduction as a component of a multimeric receptor complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A10 Gene

Genomics for MS4A10 Gene

Regulatory Elements for MS4A10 Gene

Enhancers for MS4A10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F060763 0.5 ENCODE 11.4 -21.9 -21872 0.8 HDGF TBP TBL1XR1 WRNIP1 RAD21 EGR1 ZNF143 CREM CBFB JUNB MS4A10 MS4A18 CCDC86 ENSG00000255959 MS4A8 MS4A15
GH11F060765 1.1 FANTOM5 11.4 -20.2 -20153 0.2 SRF TBP ELK1 POLR2A NFYB CREM ATF2 MS4A10 MS4A8 ENSG00000255845 CCDC86 ENSG00000255959 MS4A1 MS4A13 MS4A15
GH11F060759 0.6 Ensembl 11.4 -25.5 -25504 0.8 ZNF316 RNF2 IKZF1 SPI1 MS4A10 MS4A18 CCDC86 ENSG00000255959 MS4A8 MS4A15
GH11F060756 0.2 ENCODE 11.4 -28.5 -28522 0.2 CTCF CBFB SMC3 RAD21 MS4A10 MS4A18 CCDC86 ENSG00000255959 MS4A15
GH11F060710 0.5 ENCODE 11.2 -73.3 -73336 3.7 CTCF RAD21 MS4A8 MS4A10 CCDC86 ENSG00000255959 MS4A18 STX3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MS4A10 on UCSC Golden Path with GeneCards custom track

Genomic Location for MS4A10 Gene

Chromosome:
11
Start:
60,785,304 bp from pter
End:
60,801,305 bp from pter
Size:
16,002 bases
Orientation:
Plus strand

Genomic View for MS4A10 Gene

Genes around MS4A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MS4A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MS4A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A10 Gene

Proteins for MS4A10 Gene

  • Protein details for MS4A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PG2-M4A10_HUMAN
    Recommended name:
    Membrane-spanning 4-domains subfamily A member 10
    Protein Accession:
    Q96PG2
    Secondary Accessions:
    • B2RP45
    • Q96PG3

    Protein attributes for MS4A10 Gene

    Size:
    267 amino acids
    Molecular mass:
    29747 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MS4A10 Gene

Post-translational modifications for MS4A10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MS4A10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MS4A10 Gene

Domains & Families for MS4A10 Gene

Gene Families for MS4A10 Gene

Protein Domains for MS4A10 Gene

Suggested Antigen Peptide Sequences for MS4A10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PG2

UniProtKB/Swiss-Prot:

M4A10_HUMAN :
  • Belongs to the MS4A family.
Family:
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A10: view

Function for MS4A10 Gene

Molecular function for MS4A10 Gene

UniProtKB/Swiss-Prot Function:
May be involved in signal transduction as a component of a multimeric receptor complex.
genes like me logo Genes that share phenotypes with MS4A10: view

Animal Model Products

miRNA for MS4A10 Gene

miRTarBase miRNAs that target MS4A10

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MS4A10 Gene

Localization for MS4A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MS4A10 Gene COMPARTMENTS Subcellular localization image for MS4A10 gene
Compartment Confidence
plasma membrane 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MS4A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MS4A10: view

Pathways & Interactions for MS4A10 Gene

SuperPathways for MS4A10 Gene

No Data Available

Interacting Proteins for MS4A10 Gene

Selected Interacting proteins: Q96PG2-M4A10_HUMAN for MS4A10 Gene via IID

Symbol External ID(s) Details
C10orf35

Gene Ontology (GO) - Biological Process for MS4A10 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MS4A10 Gene

Transcripts for MS4A10 Gene

mRNA/cDNA for MS4A10 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MS4A10 Gene

Membrane-spanning 4-domains, subfamily A, member 10:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A10 Gene

No ASD Table

Relevant External Links for MS4A10 Gene

GeneLoc Exon Structure for
MS4A10
ECgene alternative splicing isoforms for
MS4A10

Expression for MS4A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MS4A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A10 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x50.9).

Protein differential expression in normal tissues from HIPED for MS4A10 Gene

This gene is overexpressed in Fetal Brain (62.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MS4A10 Gene



Protein tissue co-expression partners for MS4A10 Gene

NURSA nuclear receptor signaling pathways regulating expression of MS4A10 Gene:

MS4A10

SOURCE GeneReport for Unigene cluster for MS4A10 Gene:

Hs.591956
genes like me logo Genes that share expression patterns with MS4A10: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for MS4A10 Gene

Orthologs for MS4A10 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MS4A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MS4A10 34 35
  • 99.25 (n)
cow
(Bos Taurus)
Mammalia MS4A10 34 35
  • 72.01 (n)
rat
(Rattus norvegicus)
Mammalia Ms4a10 34
  • 68.63 (n)
mouse
(Mus musculus)
Mammalia Ms4a10 34 16 35
  • 66.52 (n)
dog
(Canis familiaris)
Mammalia MS4A10 35
  • 62 (a)
OneToOne
Species where no ortholog for MS4A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A10 Gene

ENSEMBL:
Gene Tree for MS4A10 (if available)
TreeFam:
Gene Tree for MS4A10 (if available)

Paralogs for MS4A10 Gene

No data available for Paralogs for MS4A10 Gene

Variants for MS4A10 Gene

Sequence variations from dbSNP and Humsavar for MS4A10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1032936 -- 60,799,277(-) TTACT(C/T)AGCAC intron-variant
rs10466665 -- 60,795,910(+) TGCCC(A/C)GAACA intron-variant
rs10466666 -- 60,795,917(+) AACAA(A/G)AGGCT intron-variant
rs10750942 -- 60,800,246(+) CCCTG(A/G)TTCAA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs10750943 -- 60,800,263(+) CTCCT(A/G)TCTCA intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MS4A10 Gene

Variant ID Type Subtype PubMed ID
esv3366730 CNV insertion 20981092

Variation tolerance for MS4A10 Gene

Residual Variation Intolerance Score: 84.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MS4A10 Gene

Human Gene Mutation Database (HGMD)
MS4A10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MS4A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A10 Gene

Disorders for MS4A10 Gene

Relevant External Links for MS4A10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MS4A10

No disorders were found for MS4A10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MS4A10 Gene

Publications for MS4A10 Gene

  1. Structural organization of the human MS4A gene cluster on chromosome 11q12. (PMID: 11486273) Liang Y. … Tedder T.F. (Immunogenetics 2001) 2 3 4 64
  2. Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PMID: 11401424) Liang Y. … Tedder T.F. (Genomics 2001) 2 3 64
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for MS4A10 Gene

Sources for MS4A10 Gene

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