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MS4A10 Gene

protein-coding   GIFtS: 40
GCID: GC11P060552

Membrane-Spanning 4-Domains, Subfamily A, Member 10

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Membrane-Spanning 4-Domains, Subfamily A, Member 101 2
CD20L72 3
MS4A92 3
CD20 Antigen-Like 72 3
Membrane-Spanning 4-Domains Subfamily A Member 102

External Ids:    HGNC: 133681   Entrez Gene: 3411162   Ensembl: ENSG000001726897   OMIM: 6084035   UniProtKB: Q96PG23   

Export aliases for MS4A10 gene to outside databases

Previous GC identifers: GC11P062951 GC11M062071 GC11P060809 GC11P060333 GC11P060328 GC11P060309 GC11P056899


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MS4A10 Gene:
Most MS4A genes, including MS4A10, encode proteins with at least 4 potential transmembrane domains and N- and
C-terminal cytoplasmic domains encoded by distinct exons.(supplied by OMIM, Apr 2004)

GeneCards Summary for MS4A10 Gene:
MS4A10 (membrane-spanning 4-domains, subfamily A, member 10) is a protein-coding gene.

UniProtKB/Swiss-Prot: M4A10_HUMAN, Q96PG2
Function: May be involved in signal transduction as a component of a multimeric receptor complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MS4A10 gene promoter:
         RFX1   STAT1   USF1   AML1a   Tal-1beta   GATA-1   CP2   USF-1   c-Myb   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMS4A10 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MS4A10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.2

MS4A10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MS4A10 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P060552:  view genomic region     (about GC identifiers)

Start:
60,552,821 bp from pter      End:
60,568,778 bp from pter
Size:
15,958 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: M4A10_HUMAN, Q96PG2 (See protein sequence)
Recommended Name: Membrane-spanning 4-domains subfamily A member 10  
Size: 267 amino acids; 29747 Da
Secondary accessions: B2RP45 Q96PG3

Explore the universe of human proteins at neXtProt for MS4A10: NX_Q96PG2

Explore proteomics data for MS4A10 at MOPED


See MS4A10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_996776.2  
ENSEMBL proteins: 
 ENSP00000311862  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR007237 CD20-like

Graphical View of Domain Structure for InterPro Entry Q96PG2

ProtoNet protein and cluster: Q96PG2

1 Blocks protein domain: IPB007237 CD20/IgE Fc receptor beta subunit

UniProtKB/Swiss-Prot: M4A10_HUMAN, Q96PG2
Similarity: Belongs to the MS4A family


Find genes that share domains with MS4A10           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: M4A10_HUMAN, Q96PG2
Function: May be involved in signal transduction as a component of a multimeric receptor complex

     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
Find genes that share ontologies with MS4A10           About GenesLikeMe


Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
M4A10_HUMAN, Q96PG2: Membrane; Multi-pass membrane protein (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane3
mitochondrion1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with MS4A10           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MS4A10
Interactions:

    Search GeneGlobe Interaction Network for MS4A10

1 Interacting protein for MS4A10 (Q96PG23) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
C10orf35Q96D053I2D: score=3 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for MS4A10 (M4A10)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for MS4A10 gene: 
NM_206893.3  

Unigene Cluster for MS4A10:

Membrane-spanning 4-domains, subfamily A, member 10
Hs.591956
Unigene Representative Sequence: NM_206893
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000308287(uc001npz.1)
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Additional mRNA sequence: 

AK122633.1 BC137259.1 BC137263.1 

1 DOTS entry:

DT.101954389 

2 AceView cDNA sequences:

AK122633 NM_206893 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MS4A10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGTGCAAACT
MS4A10 Expression
About this image

MS4A10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MS4A10 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.591956
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for MS4A10 gene from Selected species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ms4a101 , 5 membrane-spanning 4-domains, subfamily A, member 1 more1, 5 66.52(n)1
55.6(a)1
  19 (7.44 cM)5
698261  NM_023529.21  NP_076018.21 
 109622975 


ENSEMBL Gene Tree for MS4A10 (if available)
TreeFam Gene Tree for MS4A10 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MS4A10 (see all 488)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1853993171,2
--60550852(+) GGGTTG/TCTGGA 1 -- us2k10--------
rs1894006991,2
--60550925(+) GATCTA/GGGGTT 1 -- us2k10--------
rs1863706551,2
C--60550947(+) GGGGTC/TGTGGG 1 -- us2k10--------
rs2006224781,2
--60550985(+) CTGGA-/TCTCGGG 1 -- us2k10--------
rs340170161,2
C,F--60550987(+) GGGGG-/G/T/TG
/TGGGGGG
TCACT
1 -- us2k12NA 4
rs1820487631,2
--60551017(+) ATAGGA/TTCTGG 1 -- us2k10--------
rs1443905311,2
--60551259(+) TCACAC/GTTCCC 1 -- us2k10--------
rs1852989841,2
--60551319(+) GATTCA/TGTCAG 1 -- us2k10--------
rs1880994311,2
--60551435(+) TGATAC/GCCGGT 1 -- us2k10--------
rs1465948351,2
--60551437(+) ATACCC/TGGTAA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for MS4A10 (60552821 - 60568778 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for MS4A10:    About this table    
Variant IDTypeSubtypePubMed ID
esv273941CNV Insertion20981092
nsv897598CNV Loss21882294

Human Gene Mutation Database (HGMD): MS4A10
Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608403    OMIM disorders: --


Find genes that share disorders with MS4A10           About GenesLikeMe


Export disorders for MS4A10 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MS4A10 gene integrated from 10 sources:
(articles sorted by number of sources associating them with MS4A10)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Structural organization of the human MS4A gene cluster on chromosome 11q12. (PubMed id 11486273)1, 2, 3 Liang Y.... Tedder T.F. (Immunogenetics 2001)
  2. Identification of a CD20-, Fc-epsilon-RI-beta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. (PubMed id 11401424)1, 3 Liang Y. and Tedder T.F. (Genomics 2001)
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  7. Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor. (PubMed id 11245982)1 Ishibashi K.... Imai M. (Gene 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 341116 HGNC: 13368 AceView: MS4A10 Ensembl:ENSG00000172689 euGenes: HUgn341116
ECgene: MS4A10 H-InvDB: MS4A10

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MS4A10 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MS4A10 gene:
Search GeneIP for patents involving MS4A10

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MS4A10
 SwitchGear 3'UTR luciferase reporter plasmids for MS4A10
 SwitchGear Promoter luciferase reporter plasmids for MS4A10
 Search ThermoFisher Antibodies for MS4A10
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MS4A10
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MS4A10
 inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MS4A10
 Search LSBio for Antibodies for MS4A10
Customized transgenic rodents for:
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 Browse compounds at ApexBio
 Search Addgene for plasmids for MS4A10
  Search eBioscience for proteins for MS4A10
  Search eBioscience for elisas for MS4A10
  eBioscience FlowRNA Probe Sets
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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