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Aliases for MS4A1 Gene

Aliases for MS4A1 Gene

  • Membrane-Spanning 4-Domains, Subfamily A, Member 1 2 3
  • CD20 3 4 6
  • Leukocyte Surface Antigen Leu-16 3 4
  • CD20 Antigen 3 4
  • CVID5 3 6
  • Bp35 3 4
  • Membrane-Spanning 4-Domains Subfamily A Member 1 4
  • B-Lymphocyte Cell-Surface Antigen B1 3
  • B-Lymphocyte Surface Antigen B1 4
  • B-Lymphocyte Antigen CD20 3
  • CD20 Receptor 3
  • LEU-16 3
  • MS4A2 3
  • S7 3
  • B1 3

External Ids for MS4A1 Gene

Previous HGNC Symbols for MS4A1 Gene

  • CD20

Previous GeneCards Identifiers for MS4A1 Gene

  • GC11P062617
  • GC11P061736
  • GC11P059998
  • GC11P059979
  • GC11P060225
  • GC11P056570

Summaries for MS4A1 Gene

Entrez Gene Summary for MS4A1 Gene

  • This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MS4A1 Gene

MS4A1 (Membrane-Spanning 4-Domains, Subfamily A, Member 1) is a Protein Coding gene. Diseases associated with MS4A1 include immunodeficiency, common variable, 5 and membranous glomerulonephritis. Among its related pathways are PI-3K cascade and Immune response Fc epsilon RI pathway.

UniProtKB/Swiss-Prot for MS4A1 Gene

  • This protein may be involved in the regulation of B-cell activation and proliferation

Gene Wiki entry for MS4A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A1 Gene

Genomics for MS4A1 Gene

Regulatory Elements for MS4A1 Gene

Genomic Location for MS4A1 Gene

60,455,752 bp from pter
60,470,760 bp from pter
15,009 bases
Plus strand

Genomic View for MS4A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MS4A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A1 Gene

Proteins for MS4A1 Gene

  • Protein details for MS4A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    B-lymphocyte antigen CD20
    Protein Accession:
    Secondary Accessions:
    • A6NMS4
    • B4DT24
    • P08984
    • Q13963

    Protein attributes for MS4A1 Gene

    297 amino acids
    Molecular mass:
    33077 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MS4A1 Gene

    Alternative splice isoforms for MS4A1 Gene


neXtProt entry for MS4A1 Gene

Proteomics data for MS4A1 Gene at MOPED

Post-translational modifications for MS4A1 Gene

  • Phosphorylated. Might be functionally regulated by protein kinase(s)
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for MS4A1 Gene

Domains for MS4A1 Gene

Gene Families for MS4A1 Gene

Protein Domains for MS4A1 Gene

Suggested Antigen Peptide Sequences for MS4A1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the MS4A family.
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A1: view

Function for MS4A1 Gene

Molecular function for MS4A1 Gene

GENATLAS Biochemistry:
membrane-spanning 4-domains,subfamily A,member 1,expressed in most cells,complexing with an alpha chain and a homodimeric gamma subunit
UniProtKB/Swiss-Prot Function:
This protein may be involved in the regulation of B-cell activation and proliferation

Gene Ontology (GO) - Molecular Function for MS4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005154 epidermal growth factor receptor binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0023026 MHC class II protein complex binding IDA 20458337
genes like me logo Genes that share ontologies with MS4A1: view
genes like me logo Genes that share phenotypes with MS4A1: view

Animal Models for MS4A1 Gene

MGI Knock Outs for MS4A1:

Animal Model Products

CRISPR Products

miRNA for MS4A1 Gene

miRTarBase miRNAs that target MS4A1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MS4A1

Clone Products

  • Addgene plasmids for MS4A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MS4A1 Gene

Localization for MS4A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A1 Gene

Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor.

Subcellular locations from

Jensen Localization Image for MS4A1 Gene COMPARTMENTS Subcellular localization image for MS4A1 gene
Compartment Confidence
plasma membrane 5
nucleus 4
extracellular 1

Gene Ontology (GO) - Cellular Components for MS4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005887 integral component of plasma membrane NAS 2448768
GO:0009897 external side of plasma membrane IEA --
GO:0016021 integral component of membrane --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with MS4A1: view

Pathways for MS4A1 Gene

genes like me logo Genes that share pathways with MS4A1: view

Pathways by source for MS4A1 Gene

1 BioSystems pathway for MS4A1 Gene
1 Reactome pathway for MS4A1 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for MS4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006959 humoral immune response NAS 2448768
GO:0042100 B cell proliferation NAS 2448768
genes like me logo Genes that share ontologies with MS4A1: view

Drugs for MS4A1 Gene

(4) Drugbank Compounds for MS4A1 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • Ig gamma-2A chain C region, membrane-bound form
174722-31-7 Target antibody approved
  • Afutuzumab
949142-50-1 Target antibody approved
  • AntiCD20
174722-31-7 Target antibody approved
  • Ig gamma-1 chain C region
192391-48-3 Target antibody approved


Pharmaceutical: Monoclonal antibodies (mAb) against CD20 are used to treat B-cell non-Hodgkin lymphoma (NHL). These antibodies include Rituximab (Mabthera), Britumomab (Zevalin) and Tositumomab (Bexxar). CD20 engaged by mAb can generate transmembrane signals capable of directly controlling cell growth and triggering cell death in certain tumors. Alternatively, mAb can mediate complement-dependent cytotoxicity

(7) Novoseek inferred chemical compound relationships for MS4A1 Gene

Compound -log(P) Hits PubMed IDs
rituximab 87 64
fludarabine 44.1 1
hematoxylin 30.7 1
paraffin 28.7 2
cyclophosphamide 19.7 1

(5) PharmGKB related drug/compound annotations for MS4A1 Gene

Drug/compound Annotation
afutuzumab DrugLabel
ibritumomab DrugLabel
ofatumumab DrugLabel
rituximab DrugLabel
tositumomab DrugLabel
genes like me logo Genes that share compounds with MS4A1: view

Transcripts for MS4A1 Gene

Unigene Clusters for MS4A1 Gene

Membrane-spanning 4-domains, subfamily A, member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MS4A1

Clone Products

  • Addgene plasmids for MS4A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b
SP1: - - - - - - - -
SP2: - -
SP3: - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP7: -
SP8: - - - -
SP9: - -
SP10: - - - -
SP12: - -

Relevant External Links for MS4A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MS4A1 Gene

mRNA expression in normal human tissues for MS4A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A1 Gene

This gene is overexpressed in Spleen (12.5) and Small Intestine - Terminal Ileum (5.5).

Protein differential expression in normal tissues for MS4A1 Gene

This gene is overexpressed in Blymphocyte (27.9), Lymph node (27.9), Monocytes (6.7), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MS4A1 Gene

SOURCE GeneReport for Unigene cluster for MS4A1 Gene Hs.712553

mRNA Expression by UniProt/SwissProt for MS4A1 Gene

Tissue specificity: Expressed on B-cells
genes like me logo Genes that share expressions with MS4A1: view

Expression partners for MS4A1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for MS4A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MS4A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MS4A1 35
  • 78.9 (n)
  • 71.04 (a)
MS4A1 36
  • 67 (a)
(Canis familiaris)
Mammalia MS4A1 35
  • 84.01 (n)
  • 73.99 (a)
MS4A1 36
  • 73 (a)
(Mus musculus)
Mammalia Ms4a1 35
  • 82.87 (n)
  • 74.83 (a)
Ms4a1 16
Ms4a1 36
  • 75 (a)
(Pan troglodytes)
Mammalia MS4A1 35
  • 99.21 (n)
  • 98.99 (a)
MS4A1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Ms4a1 35
  • 83.11 (n)
  • 76.69 (a)
(Monodelphis domestica)
Mammalia MS4A1 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia MS4A1 36
  • 53 (a)
Species with no ortholog for MS4A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A1 Gene

Gene Tree for MS4A1 (if available)
Gene Tree for MS4A1 (if available)

Paralogs for MS4A1 Gene

(2) SIMAP similar genes for MS4A1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MS4A1: view

No data available for Paralogs for MS4A1 Gene

Variants for MS4A1 Gene

Sequence variations from dbSNP and Humsavar for MS4A1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs148229051 -- 60,468,707(+) AAAGG(C/T)AGAAT utr-variant-3-prime
rs200909483 -- 60,469,162(+) GCCAT(G/T)ATGCG utr-variant-3-prime
rs200879124 -- 60,468,336(+) TCTTC(C/T)CAACC reference, synonymous-codon
rs200872082 -- 60,468,624(+) TTACA(C/T)TGAAT utr-variant-3-prime
rs200868379 -- 60,470,759(+) TCATT(A/G)ACTAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MS4A1 Gene

Variant ID Type Subtype PubMed ID
esv2744569 CNV Deletion 23290073
nsv508635 CNV Loss 20534489
esv4679 CNV Deletion 18987735
esv2661434 CNV Deletion 23128226
esv2744572 CNV Deletion 23290073
nsv471730 CNV Loss 16327809
esv28830 CNV Loss 19812545

Relevant External Links for MS4A1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A1 Gene

Disorders for MS4A1 Gene

(1) OMIM Diseases for MS4A1 Gene (112210)


  • Immunodeficiency, common variable, 5 (CVID5) [MIM:613495]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269 PubMed:20038800}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(23) Novoseek inferred disease relationships for MS4A1 Gene

Disease -log(P) Hits PubMed IDs
lymphoma b-cell 79.6 8
lymphoma non-hodgkins 77.5 9
lymphoma 70.8 20
lymphocytic leukemia chronic b-cell 70.7 4
lymphoma small lymphocytic 70.5 4

Relevant External Links for MS4A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MS4A1: view

No data available for University of Copenhagen DISEASES and Genatlas for MS4A1 Gene

Publications for MS4A1 Gene

  1. Mutation or polymorphism of the CD20 gene is not associated with the response to R-CHOP in diffuse large B cell lymphoma patients. (PMID: 19054557) Sar A. … Demetrick D.J. (Leuk. Res. 2009) 3 23 48
  2. CD20 deficiency in humans results in impaired T cell-independent antibody responses. (PMID: 20038800) Kuijpers T.W. … van Lier R.A.W. (J. Clin. Invest. 2010) 3 4 23
  3. CD20 mutations involving the rituximab epitope are rare in diffuse large B-cell lymphomas and are not a significant cause of R-CHOP failure. (PMID: 19211644) Johnson N.A. … Gascoyne R.D. (Haematologica 2009) 3 23 48
  4. Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes. (PMID: 2448768) Tedder T.F. … Saito H. (Proc. Natl. Acad. Sci. U.S.A. 1988) 2 3 4
  5. Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes. (PMID: 7684739) Bubien J.K. … Tedder T.F. (J. Cell Biol. 1993) 3 23

Products for MS4A1 Gene

  • Addgene plasmids for MS4A1

Sources for MS4A1 Gene

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