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Aliases for MS4A1 Gene

Aliases for MS4A1 Gene

  • Membrane-Spanning 4-Domains, Subfamily A, Member 1 2 3
  • Leukocyte Surface Antigen Leu-16 3 4
  • CD20 Antigen 3 4
  • CD20 3 4
  • Bp35 3 4
  • Membrane-Spanning 4-Domains Subfamily A Member 1 4
  • B-Lymphocyte Cell-Surface Antigen B1 3
  • B-Lymphocyte Surface Antigen B1 4
  • CD20 Receptor 3
  • LEU-16 3
  • CVID5 3
  • MS4A2 3
  • S7 3
  • B1 3

External Ids for MS4A1 Gene

Previous HGNC Symbols for MS4A1 Gene

  • CD20

Previous GeneCards Identifiers for MS4A1 Gene

  • GC11P062617
  • GC11P061736
  • GC11P059998
  • GC11P059979
  • GC11P060225
  • GC11P056570

Summaries for MS4A1 Gene

Entrez Gene Summary for MS4A1 Gene

  • This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MS4A1 Gene

MS4A1 (Membrane-Spanning 4-Domains, Subfamily A, Member 1) is a Protein Coding gene. Diseases associated with MS4A1 include immunodeficiency, common variable, 5 and pityriasis lichenoides. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include epidermal growth factor receptor binding and MHC class II protein complex binding.

UniProtKB/Swiss-Prot for MS4A1 Gene

  • This protein may be involved in the regulation of B-cell activation and proliferation

Gene Wiki entry for MS4A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MS4A1 Gene

Genomics for MS4A1 Gene

Regulatory Elements for MS4A1 Gene

Genomic Location for MS4A1 Gene

Chromosome:
11
Start:
60,455,752 bp from pter
End:
60,470,760 bp from pter
Size:
15,009 bases
Orientation:
Plus strand

Genomic View for MS4A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MS4A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MS4A1 Gene

Proteins for MS4A1 Gene

  • Protein details for MS4A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11836-CD20_HUMAN
    Recommended name:
    B-lymphocyte antigen CD20
    Protein Accession:
    P11836
    Secondary Accessions:
    • A6NMS4
    • B4DT24
    • P08984
    • Q13963

    Protein attributes for MS4A1 Gene

    Size:
    297 amino acids
    Molecular mass:
    33077 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MS4A1 Gene

    Alternative splice isoforms for MS4A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MS4A1 Gene

Proteomics data for MS4A1 Gene at MOPED

Post-translational modifications for MS4A1 Gene

  • Phosphorylated. Might be functionally regulated by protein kinase(s)
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for MS4A1 Gene

Domains & Families for MS4A1 Gene

Gene Families for MS4A1 Gene

Protein Domains for MS4A1 Gene

Suggested Antigen Peptide Sequences for MS4A1 Gene

Graphical View of Domain Structure for InterPro Entry

P11836

UniProtKB/Swiss-Prot:

CD20_HUMAN :
  • Belongs to the MS4A family.
Family:
  • Belongs to the MS4A family.
genes like me logo Genes that share domains with MS4A1: view

Function for MS4A1 Gene

Molecular function for MS4A1 Gene

GENATLAS Biochemistry:
membrane-spanning 4-domains,subfamily A,member 1,expressed in most cells,complexing with an alpha chain and a homodimeric gamma subunit
UniProtKB/Swiss-Prot Function:
This protein may be involved in the regulation of B-cell activation and proliferation

Gene Ontology (GO) - Molecular Function for MS4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005154 epidermal growth factor receptor binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0023026 MHC class II protein complex binding IDA 20458337
genes like me logo Genes that share ontologies with MS4A1: view
genes like me logo Genes that share phenotypes with MS4A1: view

Animal Models for MS4A1 Gene

MGI Knock Outs for MS4A1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MS4A1

Clone Products

  • Addgene plasmids for MS4A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MS4A1 Gene

Localization for MS4A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MS4A1 Gene

Cell membrane; Multi-pass membrane protein. Cell membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MS4A1 Gene COMPARTMENTS Subcellular localization image for MS4A1 gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for MS4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 22664934
GO:0005887 integral component of plasma membrane NAS 2448768
GO:0009897 external side of plasma membrane IEA --
GO:0016021 integral component of membrane --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with MS4A1: view

Pathways & Interactions for MS4A1 Gene

genes like me logo Genes that share pathways with MS4A1: view

Pathways by source for MS4A1 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for MS4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006959 humoral immune response NAS 2448768
GO:0042100 B cell proliferation NAS 2448768
genes like me logo Genes that share ontologies with MS4A1: view

No data available for SIGNOR curated interactions for MS4A1 Gene

Drugs & Compounds for MS4A1 Gene

(19) Drugs for MS4A1 Gene - From: DGIdb, PharmGKB, NovoSeek, DrugBank, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
rituximab Approved Pharma antibody, Target Therapeutic Antibodies 1514
Ibritumomab Approved Pharma antibody, Target 0
Tositumomab Approved Pharma antibody, Target 0
Obinutuzumab Approved Pharma Target, antibody 63
Bexxar Approved June 2003 Pharma 0

(3) Additional Compounds for MS4A1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
HEMATOXYLIN
LIPID
Paraffin
genes like me logo Genes that share compounds with MS4A1: view

Transcripts for MS4A1 Gene

Unigene Clusters for MS4A1 Gene

Membrane-spanning 4-domains, subfamily A, member 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MS4A1

Clone Products

  • Addgene plasmids for MS4A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MS4A1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11a · 11b
SP1: - - - - - - - -
SP2: - -
SP3: - - - -
SP4: - - - - - - - -
SP5: - - - - - -
SP6:
SP7: -
SP8: - - - -
SP9: - -
SP10: - - - -
SP11:
SP12: - -

Relevant External Links for MS4A1 Gene

GeneLoc Exon Structure for
MS4A1
ECgene alternative splicing isoforms for
MS4A1

Expression for MS4A1 Gene

mRNA expression in normal human tissues for MS4A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MS4A1 Gene

This gene is overexpressed in Spleen (x12.5) and Small Intestine - Terminal Ileum (x5.5).

Protein differential expression in normal tissues from HIPED for MS4A1 Gene

This gene is overexpressed in Blymphocyte (27.9), Lymph node (27.9), Monocytes (6.7), and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MS4A1 Gene



SOURCE GeneReport for Unigene cluster for MS4A1 Gene Hs.712553

mRNA Expression by UniProt/SwissProt for MS4A1 Gene

P11836-CD20_HUMAN
Tissue specificity: Expressed on B-cells
genes like me logo Genes that share expression patterns with MS4A1: view

Protein tissue co-expression partners for MS4A1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for MS4A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MS4A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MS4A1 35
  • 78.9 (n)
  • 71.04 (a)
MS4A1 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MS4A1 35
  • 84.01 (n)
  • 73.99 (a)
MS4A1 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ms4a1 35
  • 82.87 (n)
  • 74.83 (a)
Ms4a1 16
Ms4a1 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MS4A1 35
  • 99.21 (n)
  • 98.99 (a)
MS4A1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ms4a1 35
  • 83.11 (n)
  • 76.69 (a)
oppossum
(Monodelphis domestica)
Mammalia MS4A1 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MS4A1 36
  • 53 (a)
OneToOne
Species with no ortholog for MS4A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MS4A1 Gene

ENSEMBL:
Gene Tree for MS4A1 (if available)
TreeFam:
Gene Tree for MS4A1 (if available)

Paralogs for MS4A1 Gene

(2) SIMAP similar genes for MS4A1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MS4A1: view

No data available for Paralogs for MS4A1 Gene

Variants for MS4A1 Gene

Sequence variations from dbSNP and Humsavar for MS4A1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs948312 -- 60,460,772(-) taata(A/C/T)ggccc intron-variant
rs1051461 -- 60,469,761(+) TGCCC(C/T)ACTTT utr-variant-3-prime
rs1051593 -- 60,470,518(+) CCTTA(C/T)AATAG utr-variant-3-prime
rs1051594 -- 60,470,581(+) CTCCC(C/T)GATTA utr-variant-3-prime
rs1051756 -- 60,468,799(-) GGTTG(C/T)TGATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MS4A1 Gene

Variant ID Type Subtype PubMed ID
esv2744569 CNV Deletion 23290073
nsv508635 CNV Loss 20534489
esv4679 CNV Deletion 18987735
esv2661434 CNV Deletion 23128226
esv2744572 CNV Deletion 23290073
nsv471730 CNV Loss 16327809
esv28830 CNV Loss 19812545

Variation tolerance for MS4A1 Gene

Residual Variation Intolerance Score: 56.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.93; 19.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MS4A1 Gene

HapMap Linkage Disequilibrium report
MS4A1
Human Gene Mutation Database (HGMD)
MS4A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MS4A1 Gene

Disorders for MS4A1 Gene

MalaCards: The human disease database

(17) MalaCards diseases for MS4A1 Gene - From: OMIM, ClinVar, Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
immunodeficiency, common variable, 5
  • antibody deficiency due to cd20 defect
pityriasis lichenoides
plasmablastic lymphoma
  • pbl
histiocytic sarcoma
al amyloidosis
  • amyloidosis al
- elite association
Search MS4A1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CD20_HUMAN
  • Immunodeficiency, common variable, 5 (CVID5) [MIM:613495]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269 PubMed:20038800}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MS4A1

Genetic Association Database (GAD)
MS4A1
Human Genome Epidemiology (HuGE) Navigator
MS4A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MS4A1
genes like me logo Genes that share disorders with MS4A1: view

No data available for Genatlas for MS4A1 Gene

Publications for MS4A1 Gene

  1. Circulating CD52 and CD20 levels at end of treatment predict for progression and survival in patients with chronic lymphocytic leukaemia treated with fludarabine, cyclophosphamide and rituximab (FCR). (PMID: 19895616) Alatrash G. … Wierda W.G. (Br. J. Haematol. 2010) 23 67
  2. Fine needle aspiration cytology diagnosis of primary renal lymphoma involving the pleura: a case report. (PMID: 20306993) Chatzipantelis P. … Salla C. (Acta Cytol. 2010) 23 67
  3. Rituximab inhibits B-cell receptor signaling. (PMID: 19965664) Kheirallah S. … Bezombes C. (Blood 2010) 23 67
  4. [Alteration in antibody-mediated immunity in patients with rituximab-combined chemotherapy and incidence of herpes zoster]. (PMID: 20087040) Ito K. … Emi N. (Gan To Kagaku Ryoho 2010) 23 67
  5. [Clinicopathologic features of granulocytic sarcoma: a study of 38 cases]. (PMID: 20450763) Liu H.Y. … Zhou X.J. (Zhonghua Bing Li Xue Za Zhi 2010) 23 67

Products for MS4A1 Gene

Sources for MS4A1 Gene

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