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Aliases for MRVI1 Gene

Aliases for MRVI1 Gene

  • Murine Retrovirus Integration Site 1 Homolog 2 3
  • Inositol 1,4,5-Trisphosphate Receptor-Associated CGMP Kinase Substrate 3 4
  • IP3R-Associated CGMP Kinase Substrate 2 3
  • JAW1-Related Protein MRVI1 3 4
  • JAW1L 3 4
  • IRAG 3 4
  • Inositol 1,4,5-Triphosphate Receptor-Associated CGMP Kinase Substrate 3
  • Inositol 1,4,5-Triphosphate-Associated CGMP Kinase Substrate 2
  • Protein MRVI1 3

External Ids for MRVI1 Gene

Previous GeneCards Identifiers for MRVI1 Gene

  • GC11M011608
  • GC11M011164
  • GC11M010633
  • GC11M010561
  • GC11M010553
  • GC11M010267

Summaries for MRVI1 Gene

Entrez Gene Summary for MRVI1 Gene

  • This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011]

GeneCards Summary for MRVI1 Gene

MRVI1 (Murine Retrovirus Integration Site 1 Homolog) is a Protein Coding gene. Diseases associated with MRVI1 include myeloid leukemia. Among its related pathways are Platelet homeostasis and Hemostasis. An important paralog of this gene is LRMP.

UniProtKB/Swiss-Prot for MRVI1 Gene

  • Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation.

Gene Wiki entry for MRVI1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRVI1 Gene

Genomics for MRVI1 Gene

Regulatory Elements for MRVI1 Gene

Genomic Location for MRVI1 Gene

Start:
10,573,091 bp from pter
End:
10,693,988 bp from pter
Size:
120,898 bases
Orientation:
Minus strand

Genomic View for MRVI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRVI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRVI1 Gene

Proteins for MRVI1 Gene

  • Protein details for MRVI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6F6-MRVI1_HUMAN
    Recommended name:
    Protein MRVI1
    Protein Accession:
    Q9Y6F6
    Secondary Accessions:
    • B7Z3T4
    • B7Z6I2
    • B7Z9A3
    • E9PQY6
    • F5H6A1
    • J3KQZ7
    • Q17S00
    • Q9UNY1

    Protein attributes for MRVI1 Gene

    Size:
    885 amino acids
    Molecular mass:
    96145 Da
    Quaternary structure:
    • Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 (By similarity). Interacts with PRKG1/cGKI-beta and ITPR1/IP3R type I.
    SequenceCaution:
    • Sequence=AAD25922.1; Type=Frameshift; Positions=1; Evidence={ECO:0000305}; Sequence=AAD25923.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};

    Alternative splice isoforms for MRVI1 Gene

neXtProt entry for MRVI1 Gene

Proteomics data for MRVI1 Gene at MOPED

Post-translational modifications for MRVI1 Gene

  • Phosphorylated by PRKG1/cGKI-beta; Ser-367 showed constitutive phosphorylation in platelets Whereas Ser-657 is only phosphorylated in presence of cGMP and nitric oxide (NO); Ser-670 is phosphorylated in resting platelets but increases in presence of cGMP and NO. PRKG1 inhibitor prevents phosphorylation of Ser-657 and Ser-670 in response to NO and cGMP.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRVI1 Gene

Domains for MRVI1 Gene

Protein Domains for MRVI1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRVI1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRVI1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MRVI1 Gene

Function for MRVI1 Gene

Molecular function for MRVI1 Gene

GENATLAS Biochemistry: murine retrovirus (non ecotropic) integration site 1 homolog,expressed in megakaryocytes and myeloid leukemias BXH2
UniProtKB/Swiss-Prot Function: Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation.
UniProtKB/Swiss-Prot Induction: By silencing of the transcription factor BTF3.

Gene Ontology (GO) - Molecular Function for MRVI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16990611
genes like me logo Genes that share ontologies with MRVI1: view
genes like me logo Genes that share phenotypes with MRVI1: view

Animal Models for MRVI1 Gene

MGI Knock Outs for MRVI1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRVI1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for MRVI1 Gene

Localization for MRVI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRVI1 Gene

Cytoplasm, perinuclear region. Sarcoplasmic reticulum. Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRVI1 Gene COMPARTMENTS Subcellular localization image for MRVI1 gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MRVI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS 10321731
GO:0016021 integral component of membrane IEA --
GO:0016529 sarcoplasmic reticulum IEA --
GO:0031095 platelet dense tubular network membrane TAS --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with MRVI1: view

Pathways for MRVI1 Gene

genes like me logo Genes that share pathways with MRVI1: view

Pathways by source for MRVI1 Gene

Interacting Proteins for MRVI1 Gene

Gene Ontology (GO) - Biological Process for MRVI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007596 blood coagulation TAS --
GO:0019934 cGMP-mediated signaling IEA --
GO:0045986 negative regulation of smooth muscle contraction --
GO:0060087 relaxation of vascular smooth muscle IEA --
genes like me logo Genes that share ontologies with MRVI1: view

Compounds for MRVI1 Gene

(2) HMDB Compounds for MRVI1 Gene

Compound Synonyms Cas Number PubMed IDs
Bradykinin
  • Callidin I
58-82-2
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with MRVI1: view

Transcripts for MRVI1 Gene

Unigene Clusters for MRVI1 Gene

Murine retrovirus integration site 1 homolog:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRVI1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRVI1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - -
SP7: - - - - -
SP8: - - -
SP9: - - - -
SP10: - - - - - - - - -
SP11: - - - -
SP12:
SP13:
SP14: - - - - - - - -
SP15: -

ExUns: 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for MRVI1 Gene

GeneLoc Exon Structure for
MRVI1
ECgene alternative splicing isoforms for
MRVI1

Expression for MRVI1 Gene

mRNA expression in normal human tissues for MRVI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MRVI1 Gene

This gene is overexpressed in Artery - Aorta (5.0) and Artery - Tibial (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MRVI1 Gene

SOURCE GeneReport for Unigene cluster for MRVI1 Gene Hs.501898

mRNA Expression by UniProt/SwissProt for MRVI1 Gene

Q9Y6F6-MRVI1_HUMAN
Tissue specificity: Expressed in the colon, rectum, and cultured colonic smooth muscle. Detected in various cancer cell lines.
genes like me logo Genes that share expressions with MRVI1: view

In Situ Assay Products

Orthologs for MRVI1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRVI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRVI1 35
  • 99.09 (n)
  • 98.68 (a)
MRVI1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRVI1 35
  • 89.57 (n)
  • 88.47 (a)
MRVI1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRVI1 35
  • 89.32 (n)
  • 88.25 (a)
MRVI1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrvi1 35
  • 83.79 (n)
  • 83.71 (a)
Mrvi1 16
Mrvi1 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRVI1 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 71 (a)
OneToMany
-- 36
  • 85 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mrvi1 35
  • 83.11 (n)
  • 82.81 (a)
chicken
(Gallus gallus)
Aves MRVI1 35
  • 64.03 (n)
  • 62.51 (a)
MRVI1 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRVI1 36
  • 58 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3247 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mrvi1 35
  • 60.26 (n)
  • 56.73 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100331961 35
  • 57.14 (n)
  • 52.54 (a)
mrvi1 36
  • 26 (a)
OneToOne
Species with no ortholog for MRVI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRVI1 Gene

ENSEMBL:
Gene Tree for MRVI1 (if available)
TreeFam:
Gene Tree for MRVI1 (if available)

Paralogs for MRVI1 Gene

Paralogs for MRVI1 Gene

Selected SIMAP similar genes for MRVI1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with MRVI1: view

Variants for MRVI1 Gene

Sequence variations from dbSNP and Humsavar for MRVI1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs716380 -- 10,686,565(-) GCTCT(C/T)GGGGC intron-variant
rs716381 -- 10,686,720(-) AACCA(C/T)CAGAC intron-variant
rs716382 -- 10,686,797(-) ATGCA(A/C)GGGAG intron-variant
rs716383 -- 10,686,625(-) GCCCC(C/T)ATAAG intron-variant
rs719152 -- 10,686,942(-) CAAGT(C/G)ATCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRVI1 Gene

Variant ID Type Subtype PubMed ID
nsv832063 CNV Loss 17160897
esv1458526 CNV Insertion 17803354
nsv7676 CNV Loss 18451855

Relevant External Links for MRVI1 Gene

HapMap Linkage Disequilibrium report
MRVI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRVI1 Gene

Disorders for MRVI1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MRVI1 Gene including...

Search for MRVI1 Gene in MalaCards »

Relevant External Links for MRVI1

Genetic Association Database (GAD)
MRVI1
Human Genome Epidemiology (HuGE) Navigator
MRVI1
genes like me logo Genes that share disorders with MRVI1: view

No data available for UniProtKB/Swiss-Prot for MRVI1 Gene

Publications for MRVI1 Gene

  1. InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle. (PMID: 14729908) Fritsch R.M. … Allescher H.-D. (J. Biol. Chem. 2004) 3 4 23
  2. Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1. (PMID: 10321731) Shaughnessy J.D. Jr. … Copeland N.G. (Oncogene 1999) 2 3 4
  3. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J. … Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 48
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. (PMID: 20526338) Johnson A.D. … Becker L.C. (Nat. Genet. 2010) 3 48

Products for MRVI1 Gene

Sources for MRVI1 Gene

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