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Aliases for MRVI1 Gene

Aliases for MRVI1 Gene

  • Murine Retrovirus Integration Site 1 Homolog 2 3 5
  • Inositol 1,4,5-Trisphosphate Receptor-Associated CGMP Kinase Substrate 3 4
  • IP3R-Associated CGMP Kinase Substrate 2 3
  • JAW1-Related Protein MRVI1 3 4
  • JAW1L 3 4
  • IRAG 3 4
  • Inositol 1,4,5-Triphosphate Receptor-Associated CGMP Kinase Substrate 3
  • Inositol 1,4,5-Triphosphate-Associated CGMP Kinase Substrate 2
  • Protein MRVI1 3

External Ids for MRVI1 Gene

Previous GeneCards Identifiers for MRVI1 Gene

  • GC11M011608
  • GC11M011164
  • GC11M010633
  • GC11M010561
  • GC11M010553
  • GC11M010267

Summaries for MRVI1 Gene

Entrez Gene Summary for MRVI1 Gene

  • This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011]

GeneCards Summary for MRVI1 Gene

MRVI1 (Murine Retrovirus Integration Site 1 Homolog) is a Protein Coding gene. Among its related pathways are Platelet homeostasis and Nitric oxide stimulates guanylate cyclase. An important paralog of this gene is LRMP.

UniProtKB/Swiss-Prot for MRVI1 Gene

  • Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation.

Gene Wiki entry for MRVI1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRVI1 Gene

Genomics for MRVI1 Gene

Regulatory Elements for MRVI1 Gene

Enhancers for MRVI1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G010651 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.5 +37.2 37228 9.9 PKNOX1 ARNT WRNIP1 SIN3A YY1 ZNF766 FOS DEK SP5 JUNB MRVI1 LOC101928053 LYVE1 CTR9 MTRNR2L8 MRVI1-AS1 ADM GC11M010667
GH11G010487 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +204.0 203977 5.2 PKNOX1 ATF1 ARNT SIN3A ZNF766 GATA2 ZMIZ1 FOS DEK JUNB LYVE1 AMPD3 MRVI1 ZBED5 GC11M010474 MIR4485
GH11G010588 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +102.0 101970 7.3 HDAC1 PKNOX1 ATF1 TBL1XR1 ARNT TCF12 GATA2 FOS ETV6 SMARCA5 MRVI1-AS1 RNF141 MRVI1 AMPD3 LYVE1 GC11M010566
GH11G010525 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.4 +165.9 165917 4.8 PKNOX1 FOXA2 TBL1XR1 FOSL1 ZNF766 GATA2 CBX5 EED ETV6 FOS MRVI1-AS1 MRVI1 LYVE1 RNF141 AMPD3 GC11M010568 GC11M010563
GH11G010348 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.6 +341.8 341756 7.6 PKNOX1 FOXA2 ARID4B SIN3A ZNF2 YY1 ETS1 TCF12 SLC30A9 GATA2 LYVE1 MRVI1 SBF2 ADM EIF4G2 AMPD3 PIR60970 GC11M010399 RNU6ATAC33P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRVI1 on UCSC Golden Path with GeneCards custom track

Promoters for MRVI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036791 1288 201 ZBTB33

Genomic Location for MRVI1 Gene

Chromosome:
11
Start:
10,573,091 bp from pter
End:
10,693,988 bp from pter
Size:
120,898 bases
Orientation:
Minus strand

Genomic View for MRVI1 Gene

Genes around MRVI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRVI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRVI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRVI1 Gene

Proteins for MRVI1 Gene

  • Protein details for MRVI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6F6-MRVI1_HUMAN
    Recommended name:
    Protein MRVI1
    Protein Accession:
    Q9Y6F6
    Secondary Accessions:
    • B7Z3T4
    • B7Z6I2
    • B7Z9A3
    • E9PQY6
    • F5H6A1
    • J3KQZ7
    • Q17S00
    • Q9UNY1

    Protein attributes for MRVI1 Gene

    Size:
    885 amino acids
    Molecular mass:
    96145 Da
    Quaternary structure:
    • Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 (By similarity). Interacts with PRKG1/cGKI-beta and ITPR1/IP3R type I.
    SequenceCaution:
    • Sequence=AAD25922.1; Type=Frameshift; Positions=1; Evidence={ECO:0000305}; Sequence=AAD25923.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};

    Alternative splice isoforms for MRVI1 Gene

neXtProt entry for MRVI1 Gene

Post-translational modifications for MRVI1 Gene

  • Phosphorylated by PRKG1/cGKI-beta; Ser-367 showed constitutive phosphorylation in platelets Whereas Ser-657 is only phosphorylated in presence of cGMP and nitric oxide (NO); Ser-670 is phosphorylated in resting platelets but increases in presence of cGMP and NO. PRKG1 inhibitor prevents phosphorylation of Ser-657 and Ser-670 in response to NO and cGMP.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRVI1 Gene

Domains & Families for MRVI1 Gene

Protein Domains for MRVI1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRVI1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRVI1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MRVI1 Gene

Function for MRVI1 Gene

Molecular function for MRVI1 Gene

GENATLAS Biochemistry:
murine retrovirus (non ecotropic) integration site 1 homolog,expressed in megakaryocytes and myeloid leukemias BXH2
UniProtKB/Swiss-Prot Function:
Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation.
UniProtKB/Swiss-Prot Induction:
By silencing of the transcription factor BTF3.

Gene Ontology (GO) - Molecular Function for MRVI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16990611
genes like me logo Genes that share ontologies with MRVI1: view
genes like me logo Genes that share phenotypes with MRVI1: view

Animal Models for MRVI1 Gene

MGI Knock Outs for MRVI1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRVI1 Gene

Localization for MRVI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRVI1 Gene

Cytoplasm, perinuclear region. Sarcoplasmic reticulum. Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRVI1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for MRVI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005789 endoplasmic reticulum membrane TAS 10321731
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016529 sarcoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with MRVI1: view

Pathways & Interactions for MRVI1 Gene

genes like me logo Genes that share pathways with MRVI1: view

Pathways by source for MRVI1 Gene

Gene Ontology (GO) - Biological Process for MRVI1 Gene

None

No data available for SIGNOR curated interactions for MRVI1 Gene

Drugs & Compounds for MRVI1 Gene

(2) Drugs for MRVI1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bradykinin Pharma Full agonist, Agonist Endogenous agonist at bradykinin receptors (B2 > B1) 50
calcium Nutra 0
genes like me logo Genes that share compounds with MRVI1: view

Transcripts for MRVI1 Gene

Unigene Clusters for MRVI1 Gene

Murine retrovirus integration site 1 homolog:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRVI1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - -
SP7: - - - - -
SP8: - - -
SP9: - - - -
SP10: - - - - - - - - -
SP11: - - - -
SP12:
SP13:
SP14: - - - - - - - -
SP15: -

ExUns: 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for MRVI1 Gene

GeneLoc Exon Structure for
MRVI1
ECgene alternative splicing isoforms for
MRVI1

Expression for MRVI1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRVI1 Gene

mRNA differential expression in normal tissues according to GTEx for MRVI1 Gene

This gene is overexpressed in Artery - Aorta (x5.0) and Artery - Tibial (x4.7).

Protein differential expression in normal tissues from HIPED for MRVI1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.9), Bone marrow mesenchymal stem cell (12.8), Gallbladder (9.6), and Platelet (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MRVI1 Gene



NURSA nuclear receptor signaling pathways regulating expression of MRVI1 Gene:

MRVI1

SOURCE GeneReport for Unigene cluster for MRVI1 Gene:

Hs.501898

mRNA Expression by UniProt/SwissProt for MRVI1 Gene:

Q9Y6F6-MRVI1_HUMAN
Tissue specificity: Expressed in the colon, rectum, and cultured colonic smooth muscle. Detected in various cancer cell lines.

Evidence on tissue expression from TISSUES for MRVI1 Gene

  • Nervous system(4.8)
  • Liver(4.1)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with MRVI1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRVI1 Gene

Orthologs for MRVI1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRVI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRVI1 34 35
  • 99.09 (n)
cow
(Bos Taurus)
Mammalia MRVI1 34 35
  • 89.57 (n)
dog
(Canis familiaris)
Mammalia MRVI1 34 35
  • 89.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 85 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mrvi1 34 16 35
  • 83.79 (n)
rat
(Rattus norvegicus)
Mammalia Mrvi1 34
  • 83.11 (n)
oppossum
(Monodelphis domestica)
Mammalia MRVI1 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRVI1 34 35
  • 64.03 (n)
lizard
(Anolis carolinensis)
Reptilia MRVI1 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrvi1 34
  • 60.26 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3247 34
zebrafish
(Danio rerio)
Actinopterygii LOC100331961 34
  • 57.14 (n)
mrvi1 35
  • 26 (a)
OneToOne
Species where no ortholog for MRVI1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRVI1 Gene

ENSEMBL:
Gene Tree for MRVI1 (if available)
TreeFam:
Gene Tree for MRVI1 (if available)

Paralogs for MRVI1 Gene

Paralogs for MRVI1 Gene

(1) SIMAP similar genes for MRVI1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with MRVI1: view

Variants for MRVI1 Gene

Sequence variations from dbSNP and Humsavar for MRVI1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000040027 -- 10,595,051(+) TCCCA(A/G)GTAGC intron-variant
rs1000059501 -- 10,679,024(+) TTGGA(C/T)CAAGG intron-variant
rs1000086305 -- 10,692,726(+) CAGAC(C/T)CCGGG intron-variant
rs1000119272 -- 10,572,873(+) AATCA(C/T)AGACC intron-variant, downstream-variant-500B
rs1000179507 -- 10,605,411(+) TTGAC(C/G)CAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRVI1 Gene

Variant ID Type Subtype PubMed ID
esv1458526 CNV insertion 17803354
esv3579367 CNV loss 25503493
esv3625361 CNV gain 21293372
nsv1137988 CNV deletion 24896259
nsv475816 CNV novel sequence insertion 20440878
nsv483000 CNV loss 15286789
nsv7676 CNV deletion 18451855
nsv832063 CNV loss 17160897

Variation tolerance for MRVI1 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.55; 77.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRVI1 Gene

Human Gene Mutation Database (HGMD)
MRVI1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRVI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRVI1 Gene

Disorders for MRVI1 Gene

Relevant External Links for MRVI1

Genetic Association Database (GAD)
MRVI1
Human Genome Epidemiology (HuGE) Navigator
MRVI1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRVI1

No disorders were found for MRVI1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRVI1 Gene

Publications for MRVI1 Gene

  1. InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle. (PMID: 14729908) Fritsch R.M. … Allescher H.-D. (J. Biol. Chem. 2004) 3 4 22 64
  2. Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1. (PMID: 10321731) Shaughnessy J.D. Jr. … Copeland N.G. (Oncogene 1999) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J. … Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 46 64
  5. Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. (PMID: 20526338) Johnson A.D. … Becker L.C. (Nat. Genet. 2010) 3 46 64

Products for MRVI1 Gene

Sources for MRVI1 Gene

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