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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

MRVI1 Gene

protein-coding GIFtS: 56
GCID: GC11M010594

murine retrovirus integration site 1 homolog

Explore 9 diseases affiliated with
MRVI1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Murine Retrovirus Integration Site 1 Homolog¹ ²		JAW1-Related Protein MRVI1² ³
IRAG¹ ² ³		Inositol 1,4,5-Triphosphate Receptor-Associated CGMP Kinase Substrate²
JAW1L¹ ² ³		IP3R-Associated CGMP Kinase Substrate²
Inositol 1,4,5-Trisphosphate Receptor-Associated CGMP Kinase Substrate² ³		Protein MRVI1²

External Ids:	HGNC: 7237¹	Entrez Gene: 10335²	Ensembl: ENSG00000072952⁷	OMIM: 604673⁵	UniProtKB: Q9Y6F6³

Export aliases for MRVI1 gene to outside databases

Previous GC identifers: GC11M011608 GC11M011164 GC11M010633 GC11M010561 GC11M010553 GC11M010267

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRVI1:

This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse

AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar

to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This

protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium

release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of

a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia

tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found

for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. (provided by

RefSeq, May 2011)

UniProtKB/Swiss-Prot: MRVI1_HUMAN, Q9Y6F6

Function: Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1

inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic

reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade

leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium

signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation

Gene Wiki entry for MRVI1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MRVI1 gene promoter:
RORalpha1 Pax-3 GATA-3 FOXO3a FOXO3 Cdc5 FOXO3b
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MRVI1 promoter sequence

Search SABiosciences Chromatin IP Primers for MRVI1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRVI1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15 Ensembl cytogenetic band: 11p15.3 HGNC cytogenetic band: 11p15

MRVI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRVI1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M010594: view genomic region (about GC identifiers)

Start:	10,594,638 bp from pter	End:	10,715,535 bp from pter
Size:	120,898 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: MRVI1_HUMAN, Q9Y6F6 (See protein sequence)

Recommended Name: Protein MRVI1

Size: 885 amino acids; 96145 Da

Subunit: Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1,

PLN/phospholamban, PRKG1 and ITPR1 (By similarity). Interacts with PRKG1/cGKI-beta and ITPR1/IP3R type I

Subcellular location: Cytoplasm, perinuclear region. Sarcoplasmic reticulum (By similarity). Membrane; Single-pass

membrane protein (Potential)

Sequence caution: Sequence=AAD25922.1; Type=Frameshift; Positions=1; Sequence=AAD25923.1; Type=Miscellaneous

discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon;

Secondary accessions: B7Z6I2 Q17S00 Q9UNY1

Alternative splicing: 6 isoforms: Q9Y6F6-1 Q9Y6F6-2 Q9Y6F6-3 Q9Y6F6-4 Q9Y6F6-5 Q9Y6F6-6 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MRVI1: NX_Q9Y6F6

Post-translational modifications:

Phosphorylated by PRKG1/cGKI-beta; Ser-367 showed constitutive phosphorylation in platelets Whereas Ser-657 is only

phosphorylated in presence of cGMP and nitric oxide (NO); Ser-670 is phosphorylated in resting platelets but increases

in presence of cGMP and NO. PRKG1 inhibitor prevents phosphorylation of Ser-657 and Ser-670 in response to NO and cGMP¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y6F6

MRVI1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001092049.2 NP_001093633.1 NP_001093637.1 NP_001193809.1 NP_001193810.1 NP_569056.4

ENSEMBL proteins:

ENSP00000412130 ENSP00000453013 ENSP00000437784 ENSP00000432436 ENSP00000432067

ENSP00000433296 ENSP00000434741 ENSP00000435658 ENSP00000431845 ENSP00000432325

ENSP00000433970 ENSP00000432312 ENSP00000414598 ENSP00000412229 ENSP00000448278

ENSP00000446764 ENSP00000441971 ENSP00000401205

Reactome Protein details: Q9Y6F6
Human Recombinant Protein Products for MRVI1:

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	Novus Biologicals MRVI1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for MRVI1

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	TAS	10321731
GO:0016021	integral to membrane	IEA	--
GO:0016529	sarcoplasmic reticulum	IEA	--
GO:0031095	platelet dense tubular network membrane	TAS	--
GO:0048471	perinuclear region of cytoplasm	IEA	--

MRVI1 for ontologies About GeneDecksing

MRVI1 Antibody Products:

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	Novus Biologicals MRVI1 Antibodies
	Abcam antibodies for MRVI1
	Uscn Antibodies for MRVI1
	Search ThermoFisher Antibodies for MRVI1

Assay Products for MRVI1:

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	GenScript Custom Assay Services for MRVI1
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	Uscn ELISAs and CLIAs for MRVI1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MRVI1 for domains About GeneDecksing

1 InterPro domain/family:

IPR008677 MRVI1

Graphical View of Domain Structure for InterPro Entry Q9Y6F6

ProtoNet protein and cluster: Q9Y6F6

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: MRVI1_HUMAN, Q9Y6F6

Function: Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1

inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic

reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade

leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium

signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation

Induction: By silencing of the transcription factor BTF3

Genatlas biochemistry entry for MRVI1:

murine retrovirus (non ecotropic) integration site 1 homolog,expressed in megakaryocytes and myeloid leukemias BXH2

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16990611

MRVI1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for MRVI1:

Synthetic lethal with c-Myc af

4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mrvi1):

cardiovascular system

digestive/alimentary

mortality/aging

muscle

MRVI1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for MRVI1: Mrvi1^tm2.1Jens Mrvi1^tm1Jens

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for MRVI1

miRNA Products:		OriGene 3'-UTR Clone (see all 4): MRVI1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRVI1
		8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate MRVI1 (see all 45):
		hsa-miR-3685 hsa-miR-607 hsa-miR-136 hsa-miR-3607-3p hsa-miR-640 hsa-miR-3146 hsa-miR-4328 hsa-miR-139-5p

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRVI1 (see all 7) OriGene shRNA RFP: MRVI1 OriGene siRNA: MRVI1
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		Sirion Biotech Custom design and validation of potent shRNA sequences against MRVI1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for MRVI1
			Sirion Biotech Customized adenovirus for overexpression of MRVI1 Sirion Biotech Customized adenovirus for potent knockdown of MRVI1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRVI1 (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRVI1 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MRVI1
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		Sirion Biotech Customized stable knockdown cell line services for MRVI1 Sirion Biotech Customized inducible knockdown cell line services for MRVI1 Sirion Biotech Customized stable overexpressing cell line services for MRVI1 Sirion Biotech Customized inducible overexpressing cell line services for MRVI1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRVI1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Nitric oxide stimulates guanylate cyclase

	Nitric oxide stimulates guanylate cyclase	1.00			Platelet homeostasis	0.34
	cGMP effects	0.75

Platelet activation, signaling and aggregation

Hemostasis

0.43

GnRH signaling pathway

Vascular smooth muscle contraction

0.36

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for MRVI1

	Hemostasis
	cGMP effects
	Platelet homeostasis
	Nitric oxide stimulates guanylate cyclase

1 Kegg Pathway (Kegg details for MRVI1):

Vascular smooth muscle contraction

MRVI1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MRVI1

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/6 Interacting proteins for MRVI1 (Q9Y6F6³ ENSP00000414598⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRKG1	Q13976³, ENSP00000363092⁴	I2D: score=1 STRING: ENSP00000363092
ITPR1	Q14643³, ENSP00000405934⁴	I2D: score=1 STRING: ENSP00000405934
MME	P08473³	I2D: score=2
PRKG2	ENSP00000264399⁴	STRING: ENSP00000264399
ITPR2	ENSP00000370744⁴	STRING: ENSP00000370744

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007596	blood coagulation	TAS	--

MRVI1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MRVI1

2 HMDB Compounds for MRVI1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Bradykinin	Callidin I (see all 5)	58-82-2	--
Calcium	Ca (see all 2)	7440-70-2	--

Search CenterWatch for drugs/clinical trials and news about MRVI1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for MRVI1 gene (6 alternative transcripts):

NM_001098579.2 NM_001100163.2 NM_001100167.2 NM_001206880.1 NM_001206881.1 NM_130385.3

Unigene Cluster for MRVI1:

Murine retrovirus integration site 1 homolog

Hs.501898 [show with all ESTs]

Unigene Representative Sequence: NM_130385

18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):

ENST00000423302(uc001mix.3) ENST00000558540 ENST00000541483(uc010rce.1)

ENST00000531107 ENST00000527509 ENST00000534266 ENST00000529448 ENST00000526414

ENST00000529471 ENST00000533631 ENST00000532037 ENST00000529547 ENST00000531786

ENST00000529068 ENST00000531308 ENST00000421747 ENST00000436272 ENST00000547195(uc001miz.2 uc010rcc.1 uc010rcd.1 uc009ygd.1)

miRNA Products:		OriGene 3'-UTR Clone (see all 4): MRVI1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRVI1
		8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate MRVI1 (see all 45):
		hsa-miR-3685 hsa-miR-607 hsa-miR-136 hsa-miR-3607-3p hsa-miR-640 hsa-miR-3146 hsa-miR-4328 hsa-miR-139-5p

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRVI1 (see all 7) OriGene shRNA RFP: MRVI1 OriGene siRNA: MRVI1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRVI1
		Sirion Biotech Custom design and validation of potent shRNA sequences against MRVI1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRVI1 (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRVI1 (see all 5) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 4): MRVI1 (NM_130385)
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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat MRVI1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRVI1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRVI1

Additional cDNA sequence:

AF081249.1 AF081250.1 AK002039.1 AK127209.1 AK296336.1 AK300358.1 AK304702.1 AL117524.1

AL832178.1 BC117127.1

14 DOTS entries:

DT.95157783 DT.97839774 DT.120736704 DT.40121511 DT.120736761 DT.120736700 DT.120736702 DT.412690

DT.100678212 DT.120736721 DT.120736817 DT.95112574 DT.120736703 DT.91744500

24/140 AceView cDNA sequences (see all 140):

BQ005063 BM681559 AI418315 BM726385 AI584169 CK725013 CA393729 CA394455

N63481 AI924033 AA669696 AI355752 CF457309 BE048764 BQ017459 AL117524

AI420623 AA999864 AV714494 CN483085 BE223107 AK002039 BQ185235 CN480949

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for MRVI1 (see all 15) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	·	1g	^	2	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	·	5d	^	6a	·	6b	·	6c	·	6d	·	6e	^	7	^	8a	·	8b	^	9a	·	9b	·	9c	^
SP1:															-				-		-		-		-		-		-		-		-		-		-		-
SP2:																			-		-										-		-		-		-		-
SP3:																			-		-		-								-		-		-		-		-
SP4:																			-		-		-				-		-		-		-		-		-		-		-		-		-		-		-		-
SP5:															-		-		-		-		-		-		-		-		-		-		-		-		-

ExUns:	10	^	11	^	12	^	13	^	14	^	15
SP1:
SP2:
SP3:
SP4:	-		-		-		-
SP5:

ECgene alternative splicing isoforms for MRVI1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

MRVI1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTTAAGCC

About this image

MRVI1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Primitive Heart Tube

Primitive Heart Tube Cells

Myocardium

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See MRVI1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRVI1

SOURCE GeneReport for Unigene cluster: Hs.501898

UniProtKB/Swiss-Prot: MRVI1_HUMAN, Q9Y6F6

Tissue specificity: Expressed in the colon, rectum, and cultured colonic smooth muscle. Detected in various cancer cell

lines

SABiosciences Custom PCR Arrays for MRVI1

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRVI1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRVI1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for MRVI1 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	MRVI1¹	murine retrovirus integration site 1 homolog	64.9(n) 63.28(a)		423037 XM_420970.3 XP_420970.3
lizard (Anolis carolinensis)	Reptilia	MRVI1⁶	--	58(a)	1 ↔ 1	1(63444018-63474677)
African clawed frog (Xenopus laevis)	Amphibia	Xl.3247²	Xenopus laevis transcribed sequence with weak similarity more	72.18(n)		48026138
zebrafish (Danio rerio)	Actinopterygii	CU468622.1⁶ si:ch73-352p18.4⁶ (see all 3)	si:ch73-352p18.4 (see all 3)	45(a) 20(a) (see all 3)	1 ↔ 1 possible ortholog (see all 3)	7(68666673-68705050) 22(1008914-1022952)

ENSEMBL Gene Tree for MRVI1 (if available)
TreeFam Gene Tree for MRVI1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for MRVI1 gene

LRMP²

1 SIMAP similar gene for MRVI1 using alignment to 12 protein entries: MRVI1_HUMAN (see all proteins):

LRMP

MRVI1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183173045^1,2		--	10594165(+)	`CTTCCA/GTCTAG`	10	--	ds500¹ int¹		0	--	--	--	--
rs189203125^1,2		--	10594272(+)	`AGGAGA/CGTTTA`	10	--	ds500¹ int¹		0	--	--	--	--
rs190747512^1,2		--	10594410(+)	`TAATTA/TAAAAA`	10	--	int¹ ds500¹		0	--	--	--	--
rs11042882^1,2	C,F,H	--	10594503(+)	`GCCCAC/TAGTAT`	10	--	ds500¹ int¹		27		EA NA NS WA	2920
rs183032928^1,2		--	10594689(+)	`TCTACA/GGTTCA`	10	--	ut3¹ int¹		0	--	--	--	--
rs148499873^1,2		--	10594801(+)	`GGGGAA/GCAACA`	10	--	ut3¹ int¹		0	--	--	--	--
rs117479720^1,2	C,F	--	10595075(+)	`NNNNTG/TAGCAC`	10	--	ut3¹ int¹		1		NA	120
rs114339939^1,2	C,F	--	10595115(+)	`TTATGC/TTCCCT`	10	--	ut3¹ int¹		1		WA	118
rs187608548^1,2	C	--	10595338(+)	`TGCTTA/TAAGGG`	10	--	ut3¹ int¹		0	--	--	--	--
rs75750657^1,2	F	--	10595345(+)	`AGGGAG/AGCAGA`	10	--	ut3¹ int¹		1		WA	118

HapMap Linkage Disequilibrium report for MRVI1 (10594638 - 10715535 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MRVI1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRVI1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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MRVI1 for disorders           About GeneDecksing

OMIM gene information: 604673    OMIM disorders: --

9 diseases for MRVI1:    About MalaCards

myeloid leukemia leukemia keratoconus ovarian carcinoma

pancreatic cancer prostate cancer pancreatitis prostatitis

carcinoma

Human Genome Epidemiology (HuGE) Navigator: MRVI1 (3 documents)

Export disorders for MRVI1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MRVI1 gene, integrated from 9 sources (see all 25):
(articles sorted by number of sources associating them with MRVI1)

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Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1. (PubMed id 10321731)^{1, 2, 3} Shaughnessy J.D. Jr.... Copeland N.G. (1999)
InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle. (PubMed id 14729908)^{1, 2, 9} Fritsch R.M.... Allescher H.-D. (2004)
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation. (PubMed id 16990611)^{1, 2} Antl M.... Schlossmann J. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Association of phospholamban with a cGMP kinase signaling complex. (PubMed id 12480535)^{1, 9} Koller A....Hofmann F. (2003)
Signaling via IRAG is essential for NO/cGMP-dependent inhibition of platelet activation. (PubMed id 21244222)¹ Schinner E....Schlossmann J. (2011)
Truncated IRAG variants modulate cGMP-mediated inhibi tion of human colonic smooth muscle cell contraction. (PubMed id 21865585)¹ Werder A....Saur D. (2011)
Genome-wide meta-analyses identifies seven loci assoc iated with platelet aggregation in response to agonists. (PubMed id 20526338)¹ Johnson A.D....Becker L.C. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Functional osteoclast attachment requires inositol-1, 4,5-trisphosphate receptor-associated cGMP-dependent kinase substrate. (PubMed id 20567233)¹ Yaroslavskiy B.B....Blair H.C. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 10335	HGNC: 7237	AceView: MRVI1	Ensembl:ENSG00000072952	euGenes: HUgn10335
ECgene: MRVI1	Kegg: 10335	H-InvDB: MRVI1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for MRVI1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for MRVI1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for MRVI1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for MRVI1 gene:
Search GeneIP for patents involving MRVI1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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MRVI1 Gene

murine retrovirus integration site 1 homolog

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MRVI1 Gene

murine retrovirus integration site 1 homolog

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