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Aliases for MRVI1 Gene

Aliases for MRVI1 Gene

  • Murine Retrovirus Integration Site 1 Homolog 2 3 5
  • Inositol 1,4,5-Trisphosphate Receptor-Associated CGMP Kinase Substrate 3 4
  • IP3R-Associated CGMP Kinase Substrate 2 3
  • JAW1-Related Protein MRVI1 3 4
  • JAW1L 3 4
  • IRAG 3 4
  • Inositol 1,4,5-Triphosphate Receptor-Associated CGMP Kinase Substrate 3
  • Inositol 1,4,5-Triphosphate-Associated CGMP Kinase Substrate 2
  • Protein MRVI1 3

External Ids for MRVI1 Gene

Previous GeneCards Identifiers for MRVI1 Gene

  • GC11M011608
  • GC11M011164
  • GC11M010633
  • GC11M010561
  • GC11M010553
  • GC11M010267

Summaries for MRVI1 Gene

Entrez Gene Summary for MRVI1 Gene

  • This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011]

GeneCards Summary for MRVI1 Gene

MRVI1 (Murine Retrovirus Integration Site 1 Homolog) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Nitric oxide stimulates guanylate cyclase. An important paralog of this gene is LRMP.

UniProtKB/Swiss-Prot for MRVI1 Gene

  • Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation.

Gene Wiki entry for MRVI1 Gene

Additional gene information for MRVI1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRVI1 Gene

Genomics for MRVI1 Gene

GeneHancer (GH) Regulatory Elements for MRVI1 Gene

Promoters and enhancers for MRVI1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I010651 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 563.5 +37.2 37227 9.9 PKNOX1 ARNT SIN3A YY1 ZNF766 ZNF143 FOS DEK SP5 JUNB MRVI1 LYVE1 CTR9 MTRNR2L8 MRVI1-AS1 ADM GC11M010667 GC11M010630
GH11I010692 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 550.8 0.0 -47 3.5 POLR2A VEZF1 NR2C2 MRVI1 GC11P010725 GC11M010630
GH11I010454 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 9.4 +236.7 236719 6.4 HDGF ATF1 PKNOX1 FOXA2 ARNT IRF4 YY1 TCF12 CBX5 GATA2 AMPD3 CTR9 MTRNR2L8 RPL21P97 LYVE1 MRVI1 GC11M010466 GC11P010430
GH11I010750 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.7 -57.4 -57370 2.1 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CTR9 ENSG00000255125 MRVI1 GC11M010630
GH11I010348 Enhancer 2.1 VISTA FANTOM5 Ensembl ENCODE dbSUPER 9.6 +341.8 341755 7.6 FOXA2 ARID4B SIN3A ZNF2 YY1 ETS1 SLC30A9 TCF12 FOS ATF7 LYVE1 MRVI1 SBF2 ADM EIF4G2 AMPD3 PIR60970 CAND1.11 GC11M010399 RNU6ATAC33P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MRVI1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRVI1 gene promoter:

Genomic Locations for MRVI1 Gene

Genomic Locations for MRVI1 Gene
chr11:10,573,091-10,693,988
(GRCh38/hg38)
Size:
120,898 bases
Orientation:
Minus strand
chr11:10,594,638-10,715,535
(GRCh37/hg19)

Genomic View for MRVI1 Gene

Genes around MRVI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRVI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRVI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRVI1 Gene

Proteins for MRVI1 Gene

  • Protein details for MRVI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6F6-MRVI1_HUMAN
    Recommended name:
    Protein MRVI1
    Protein Accession:
    Q9Y6F6
    Secondary Accessions:
    • B7Z3T4
    • B7Z6I2
    • B7Z9A3
    • E9PQY6
    • F5H6A1
    • J3KQZ7
    • Q17S00
    • Q9UNY1

    Protein attributes for MRVI1 Gene

    Size:
    885 amino acids
    Molecular mass:
    96145 Da
    Quaternary structure:
    • Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 (By similarity). Interacts with PRKG1/cGKI-beta and ITPR1/IP3R type I.
    SequenceCaution:
    • Sequence=AAD25922.1; Type=Frameshift; Positions=1; Evidence={ECO:0000305}; Sequence=AAD25923.1; Type=Miscellaneous discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.; Evidence={ECO:0000305};

    Alternative splice isoforms for MRVI1 Gene

neXtProt entry for MRVI1 Gene

Post-translational modifications for MRVI1 Gene

  • Phosphorylated by PRKG1/cGKI-beta; Ser-367 showed constitutive phosphorylation in platelets Whereas Ser-657 is only phosphorylated in presence of cGMP and nitric oxide (NO); Ser-670 is phosphorylated in resting platelets but increases in presence of cGMP and NO. PRKG1 inhibitor prevents phosphorylation of Ser-657 and Ser-670 in response to NO and cGMP.

No data available for DME Specific Peptides for MRVI1 Gene

Domains & Families for MRVI1 Gene

Gene Families for MRVI1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for MRVI1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRVI1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRVI1: view

No data available for UniProtKB/Swiss-Prot for MRVI1 Gene

Function for MRVI1 Gene

Molecular function for MRVI1 Gene

GENATLAS Biochemistry:
murine retrovirus (non ecotropic) integration site 1 homolog,expressed in megakaryocytes and myeloid leukemias BXH2
UniProtKB/Swiss-Prot Function:
Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation.
UniProtKB/Swiss-Prot Induction:
By silencing of the transcription factor BTF3.

Phenotypes From GWAS Catalog for MRVI1 Gene

Gene Ontology (GO) - Molecular Function for MRVI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16990611
genes like me logo Genes that share ontologies with MRVI1: view
genes like me logo Genes that share phenotypes with MRVI1: view

Animal Models for MRVI1 Gene

MGI Knock Outs for MRVI1:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRVI1 Gene

Localization for MRVI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRVI1 Gene

Cytoplasm, perinuclear region. Sarcoplasmic reticulum. Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRVI1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MRVI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005789 endoplasmic reticulum membrane TAS 10321731
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016529 sarcoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with MRVI1: view

Pathways & Interactions for MRVI1 Gene

genes like me logo Genes that share pathways with MRVI1: view

Pathways by source for MRVI1 Gene

Gene Ontology (GO) - Biological Process for MRVI1 Gene

None

No data available for SIGNOR curated interactions for MRVI1 Gene

Drugs & Compounds for MRVI1 Gene

(2) Drugs for MRVI1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Bradykinin Investigational Pharma Full agonist, Agonist Endogenous agonist at bradykinin receptors (B2 > B1) 52
genes like me logo Genes that share compounds with MRVI1: view

Transcripts for MRVI1 Gene

Unigene Clusters for MRVI1 Gene

Murine retrovirus integration site 1 homolog:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRVI1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - -
SP7: - - - - -
SP8: - - -
SP9: - - - -
SP10: - - - - - - - - -
SP11: - - - -
SP12:
SP13:
SP14: - - - - - - - -
SP15: -

ExUns: 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4: - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for MRVI1 Gene

GeneLoc Exon Structure for
MRVI1
ECgene alternative splicing isoforms for
MRVI1

Expression for MRVI1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRVI1 Gene

mRNA differential expression in normal tissues according to GTEx for MRVI1 Gene

This gene is overexpressed in Artery - Aorta (x5.0) and Artery - Tibial (x4.7).

Protein differential expression in normal tissues from HIPED for MRVI1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.9), Bone marrow mesenchymal stem cell (12.8), Gallbladder (9.6), and Platelet (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MRVI1 Gene



NURSA nuclear receptor signaling pathways regulating expression of MRVI1 Gene:

MRVI1

SOURCE GeneReport for Unigene cluster for MRVI1 Gene:

Hs.501898

mRNA Expression by UniProt/SwissProt for MRVI1 Gene:

Q9Y6F6-MRVI1_HUMAN
Tissue specificity: Expressed in the colon, rectum, and cultured colonic smooth muscle. Detected in various cancer cell lines.

Evidence on tissue expression from TISSUES for MRVI1 Gene

  • Nervous system(4.8)
  • Liver(4.1)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with MRVI1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRVI1 Gene

Orthologs for MRVI1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRVI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRVI1 33 34
  • 99.09 (n)
cow
(Bos Taurus)
Mammalia MRVI1 33 34
  • 89.57 (n)
dog
(Canis familiaris)
Mammalia MRVI1 33 34
  • 89.32 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 85 (a)
OneToMany
-- 34
  • 71 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mrvi1 33 16 34
  • 83.79 (n)
rat
(Rattus norvegicus)
Mammalia Mrvi1 33
  • 83.11 (n)
oppossum
(Monodelphis domestica)
Mammalia MRVI1 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRVI1 33 34
  • 64.03 (n)
lizard
(Anolis carolinensis)
Reptilia MRVI1 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrvi1 33
  • 60.26 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3247 33
zebrafish
(Danio rerio)
Actinopterygii LOC100331961 33
  • 57.14 (n)
mrvi1 34
  • 26 (a)
OneToOne
Species where no ortholog for MRVI1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRVI1 Gene

ENSEMBL:
Gene Tree for MRVI1 (if available)
TreeFam:
Gene Tree for MRVI1 (if available)

Paralogs for MRVI1 Gene

Paralogs for MRVI1 Gene

(1) SIMAP similar genes for MRVI1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with MRVI1: view

Variants for MRVI1 Gene

Sequence variations from dbSNP and Humsavar for MRVI1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000040027 -- 10,595,051(-) A/G intron_variant
rs1000059501 -- 10,679,024(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000086305 -- 10,692,726(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000119272 -- 10,572,873(-) T/C downstream_transcript_variant
rs1000179507 -- 10,605,411(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MRVI1 Gene

Variant ID Type Subtype PubMed ID
esv1458526 CNV insertion 17803354
esv3579367 CNV loss 25503493
esv3625361 CNV gain 21293372
nsv1137988 CNV deletion 24896259
nsv475816 CNV novel sequence insertion 20440878
nsv483000 CNV loss 15286789
nsv7676 CNV deletion 18451855
nsv832063 CNV loss 17160897

Variation tolerance for MRVI1 Gene

Residual Variation Intolerance Score: 95.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.55; 77.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRVI1 Gene

Human Gene Mutation Database (HGMD)
MRVI1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRVI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRVI1 Gene

Disorders for MRVI1 Gene

Additional Disease Information for MRVI1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRVI1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRVI1 Gene

Publications for MRVI1 Gene

  1. InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle. (PMID: 14729908) Fritsch RM … Allescher HD (The Journal of biological chemistry 2004) 3 4 22 58
  2. Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1. (PMID: 10321731) Shaughnessy JD … Copeland NG (Oncogene 1999) 2 3 4 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PMID: 20080650) Xu J … Isaacs WB (Proceedings of the National Academy of Sciences of the United States of America 2010) 3 44 58
  5. Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. (PMID: 20526338) Johnson AD … Becker LC (Nature genetics 2010) 3 44 58

Products for MRVI1 Gene

Sources for MRVI1 Gene

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