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MRVI1 Gene

protein-coding   GIFtS: 60
GCID: GC11M010594

Murine Retrovirus Integration Site 1 Homolog

  See MRVI1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Murine Retrovirus Integration Site 1 Homolog1 2     41
IP3R-Associated CGMP Kinase Substrate1 2     5-Triphosphate-Associated CGMP Kinase Substrate1
Inositol 1,4,5-Trisphosphate Receptor-Associated CGMP Kinase Substrate2 3     Inositol 11
IRAG2 3     Inositol 1,4,5-Triphosphate Receptor-Associated CGMP Kinase Substrate2
JAW1L2 3     Protein MRVI12
JAW1-Related Protein MRVI12 3     

External Ids:    HGNC: 72371   Entrez Gene: 103352   Ensembl: ENSG000000729527   OMIM: 6046735   UniProtKB: Q9Y6F63   

Export aliases for MRVI1 gene to outside databases

Previous GC identifers: GC11M011608 GC11M011164 GC11M010633 GC11M010561 GC11M010553 GC11M010267


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRVI1 Gene:
This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse
AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is
similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid
differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator
of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia
by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene
may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants
encoding different isoforms have been found for this gene, and alternative translation start sites, including a
non-AUG (CUG) start site, are used. (provided by RefSeq, May 2011)

GeneCards Summary for MRVI1 Gene:
MRVI1 (murine retrovirus integration site 1 homolog) is a protein-coding gene. Diseases associated with MRVI1 include myeloid leukemia. An important paralog of this gene is LRMP.

UniProtKB/Swiss-Prot: MRVI1_HUMAN, Q9Y6F6
Function: Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by
PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the
endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1
signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent
inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation

Gene Wiki entry for MRVI1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRVI1 gene promoter:
         RORalpha1   Pax-3   GATA-3   FOXO3a   FOXO3   Cdc5   FOXO3b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRVI1 promoter sequence
   Search Chromatin IP Primers for MRVI1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRVI1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.3   HGNC cytogenetic band: 11p15

MRVI1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRVI1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M010594:  view genomic region     (about GC identifiers)

Start:
10,594,638 bp from pter      End:
10,715,535 bp from pter
Size:
120,898 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: MRVI1_HUMAN, Q9Y6F6 (See protein sequence)
Recommended Name: Protein MRVI1  
Size: 885 amino acids; 96145 Da
Subunit: Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1,
PLN/phospholamban, PRKG1 and ITPR1 (By similarity). Interacts with PRKG1/cGKI-beta and ITPR1/IP3R type I
Sequence caution: Sequence=AAD25922.1; Type=Frameshift; Positions=1; Sequence=AAD25923.1; Type=Miscellaneous
discrepancy; Note=Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon;
Secondary accessions: B7Z3T4 B7Z6I2 B7Z9A3 E9PQY6 F5H6A1 J3KQZ7 Q17S00 Q9UNY1
Alternative splicing: 9 isoforms:  Q9Y6F6-1   Q9Y6F6-2   Q9Y6F6-3   Q9Y6F6-4   Q9Y6F6-5   Q9Y6F6-6   Q9Y6F6-7   Q9Y6F6-8   
Q9Y6F6-9   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MRVI1: NX_Q9Y6F6

Explore proteomics data for MRVI1 at MOPED

Post-translational modifications: 

  • Phosphorylated by PRKG1/cGKI-beta; Ser-367 showed constitutive phosphorylation in platelets Whereas Ser-657 is
    only phosphorylated in presence of cGMP and nitric oxide (NO); Ser-670 is phosphorylated in resting platelets but
    increases in presence of cGMP and NO. PRKG1 inhibitor prevents phosphorylation of Ser-657 and Ser-670 in response
    to NO and cGMP1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MRVI1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001092049.2  NP_001093633.1  NP_001093637.1  NP_001193809.1  NP_001193810.1  NP_569056.4  

    ENSEMBL proteins: 
     ENSP00000412130   ENSP00000453013   ENSP00000437784   ENSP00000432436   ENSP00000432067  
     ENSP00000433296   ENSP00000434741   ENSP00000435658   ENSP00000431845   ENSP00000432325  
     ENSP00000433970   ENSP00000432312   ENSP00000414598   ENSP00000412229   ENSP00000448278  
     ENSP00000446764   ENSP00000441971   ENSP00000401205  
    Reactome Protein details: Q9Y6F6

    MRVI1 Human Recombinant Protein Products:

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    Novus Biologicals MRVI1 Protein
    Novus Biologicals MRVI1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MRVI1

     
    Search eBioscience for Proteins for MRVI1 

     
    antibodies-online proteins for MRVI1 

     
    antibodies-online peptides for MRVI1

    MRVI1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    antibodies-online antibodies for MRVI1 (4 products) 

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    Cloud-Clone Corp. ELISAs for MRVI1
    Cloud-Clone Corp. CLIAs for MRVI1
    Search eBioscience for ELISAs for MRVI1 
    antibodies-online kits for MRVI1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR008677 MRVI1

    Graphical View of Domain Structure for InterPro Entry Q9Y6F6

    ProtoNet protein and cluster: Q9Y6F6


    Find genes that share domains with MRVI1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRVI1_HUMAN, Q9Y6F6
    Function: Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by
    PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the
    endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1
    signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent
    inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation
    Induction: By silencing of the transcription factor BTF3

         Genatlas biochemistry entry for MRVI1:
    murine retrovirus (non ecotropic) integration site 1 homolog,expressed in megakaryocytes and myeloid leukemias
    BXH2

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16990611
         
    Find genes that share ontologies with MRVI1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MRVI1:
     Synthetic lethal with c-Myc af 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mrvi1):
     cardiovascular system  digestive/alimentary  mortality/aging  muscle 

    Find genes that share phenotypes with MRVI1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for MRVI1: Mrvi1tm2.1Jens Mrvi1tm1Jens

       genOway: Develop your customized and physiologically relevant rodent model for MRVI1

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MRVI1 (see all 45):
    hsa-miR-3685 hsa-miR-607 hsa-miR-136 hsa-miR-3607-3p hsa-miR-640 hsa-miR-3146 hsa-miR-4328 hsa-miR-139-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat MRVI1

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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): MRVI1 (NM_130385)
    Sino Biological Human cDNA Clone for MRVI1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRVI1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRVI1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRVI1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MRVI1_HUMAN, Q9Y6F6: Cytoplasm, perinuclear region. Sarcoplasmic reticulum (By similarity). Membrane; Single-pass
    membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    cytosol1
    golgi apparatus1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS10321731
    GO:0016021integral component of membrane IEA--
    GO:0016529sarcoplasmic reticulum IEA--
    GO:0031095platelet dense tubular network membrane TAS--
    GO:0048471perinuclear region of cytoplasm IEA--

    Find genes that share ontologies with MRVI1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MRVI1 About    
    See pathways by source

    SuperPathContained pathways About
    1Nitric oxide stimulates guanylate cyclase
    Nitric oxide stimulates guanylate cyclase
    cGMP effects0.00
    2Hemostasis
    Hemostasis0.43
    3Oxytocin signaling pathway
    Vascular smooth muscle contraction0.32
    4Platelet homeostasis
    Platelet homeostasis


    Find genes that share SuperPaths with MRVI1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for MRVI1
        cGMP effects


    1 Kegg Pathway  (Kegg details for MRVI1):
        Vascular smooth muscle contraction

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRVI1
    Interactions:

        Search GeneGlobe Interaction Network for MRVI1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for MRVI1 (Q9Y6F63 ENSP000004145984) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKG1Q139763, ENSP000003630924I2D: score=1 STRING: ENSP00000363092
    ITPR1Q146433, ENSP000004059344I2D: score=1 STRING: ENSP00000405934
    MMEP084733I2D: score=2 
    PRKG2ENSP000002643994STRING: ENSP00000264399
    ITPR2ENSP000003707444STRING: ENSP00000370744
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007596blood coagulation TAS--

    Find genes that share ontologies with MRVI1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRVI1

    2 HMDB Compounds for MRVI1    About this table
    CompoundSynonyms CAS #PubMed Ids
    BradykininCallidin I (see all 5)58-82-2--
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MRVI1 gene (6 alternative transcripts): 
    NM_001098579.2  NM_001100163.2  NM_001100167.2  NM_001206880.1  NM_001206881.1  NM_130385.3  

    Unigene Cluster for MRVI1:

    Murine retrovirus integration site 1 homolog
    Hs.501898  [show with all ESTs]
    Unigene Representative Sequence: NM_130385
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000423302(uc001mix.3) ENST00000558540 ENST00000541483(uc010rce.1)
    ENST00000531107 ENST00000527509 ENST00000534266 ENST00000529448 ENST00000526414
    ENST00000529471 ENST00000533631 ENST00000532037 ENST00000529547 ENST00000531786
    ENST00000529068 ENST00000531308 ENST00000421747 ENST00000436272 ENST00000547195(uc001miz.2 uc010rcc.1 uc010rcd.1 uc009ygd.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate MRVI1 (see all 45):
    hsa-miR-3685 hsa-miR-607 hsa-miR-136 hsa-miR-3607-3p hsa-miR-640 hsa-miR-3146 hsa-miR-4328 hsa-miR-139-5p
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRVI1
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      QuantiTect SYBR Green Assays in human, mouse, rat MRVI1
      QuantiFast Probe-based Assays in human, mouse, rat MRVI1

    Additional mRNA sequence: 

    AF081249.1 AF081250.1 AK002039.1 AK127209.1 AK296336.1 AK300358.1 AK304702.1 AL117524.1 
    AL832178.1 BC117127.1 

    14 DOTS entries:

    DT.95157783  DT.97839774  DT.120736704  DT.40121511  DT.120736761  DT.120736700  DT.120736702  DT.412690 
    DT.100678212  DT.120736721  DT.120736817  DT.95112574  DT.120736703  DT.91744500 

    Selected AceView cDNA sequences (see all 140):

    BE223107 N63487 BM684632 AW954901 N94780 N63481 AL045243 CN483085 
    BQ185235 AK002039 AK127209 BM677922 CN480949 AI358104 CF457309 AI355752 
    AA669696 CA393729 CK725013 BM726385 AI420623 AI584169 BQ017459 BE048764 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MRVI1 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^
    SP1:                                            -           -     -     -     -     -     -     -     -     -     -     -                                       
    SP2:                                                        -     -                             -     -     -     -     -                                       
    SP3:                                                        -     -     -                       -     -     -     -     -                                       
    SP4:                                                        -     -     -           -     -     -     -     -     -     -     -     -     -     -     -     -   
    SP5:                                            -     -     -     -     -     -     -     -     -     -     -     -     -                                       

    ExUns: 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:  -     -     -     -               
    SP5:                                    


    ECgene alternative splicing isoforms for MRVI1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRVI1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGTTAAGCC
    MRVI1 Expression
    About this image


    MRVI1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hepatocytes Liver Lobule
             Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Heart (Cardiovascular System)
             Primitive Heart Tube Cells Primitive Heart Tube
    MRVI1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRVI1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.501898

    UniProtKB/Swiss-Prot: MRVI1_HUMAN, Q9Y6F6
    Tissue specificity: Expressed in the colon, rectum, and cultured colonic smooth muscle. Detected in various cancer
    cell lines

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for MRVI1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrvi11 , 5 MRV integration site 11, 5 83.79(n)1
    83.71(a)1
      7 (57.90 cM)5
    175401  NM_010826.51  NP_034956.21 
     1108682665 
    chicken
    (Gallus gallus)
    Aves MRVI11 murine retrovirus integration site 1 homolog 64.03(n)
    62.51(a)
      423037  XM_420970.4  XP_420970.4 
    lizard
    (Anolis carolinensis)
    Reptilia MRVI16
    murine retrovirus integration site 1 homolog
    58(a)
    1 ↔ 1
    1(63435458-63479138)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.32472 Xenopus laevis transcribed sequence with weak similarity more 72.18(n)    48026138 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003319611 protein MRVI1-like 57.14(n)
    52.54(a)
      100331961  XM_002662998.3  XP_002663044.3 


    ENSEMBL Gene Tree for MRVI1 (if available)
    TreeFam Gene Tree for MRVI1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MRVI1 gene
    LRMP2  
    1 SIMAP similar gene for MRVI1 using alignment to 8 protein entries:     MRVI1_HUMAN (see all proteins):
    LRMP

    Find genes that share paralogs with MRVI1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MRVI1 (see all 2111)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1427052551,2
    --10622137(+) GCACAC/TGGACT 6 -- int10--------
    rs169080201,2
    C,F,H--10622278(+) TTTCCT/GGGTTC 6 -- int119Minor allele frequency- G:0.02NA NS EA WA 1782
    rs1996762291,2
    C--10622482(+) AGCTGC/TGGCTT 12 H R mis10--------
    rs2019764121,2
    C--10622544(+) TCATAC/TGTCCT 12 T syn10--------
    rs3760566971,2
    C--10622610(+) TCCTGA/C/TGGGGA 6 -- int10--------
    rs793867781,2
    C,F--10622611(+) CCTGCG/AGGGAA 6 -- int12Minor allele frequency- A:0.03NA EU 713
    rs1473667231,2
    --10622646(+) TTGGAA/GGAAAG 6 -- int10--------
    rs1921545421,2
    --10622690(+) TCTGGG/TCTAGG 6 -- int10--------
    rs1158867751,2
    F--10622842(+) AGGAGA/GGTTGT 6 -- int11Minor allele frequency- G:0.02WA 118
    rs1395714631,2
    --10622865(+) AGAACA/GGGTCA 6 -- int10--------

    HapMap Linkage Disequilibrium report for MRVI1 (10594638 - 10715535 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MRVI1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1458526CNV Insertion17803354
    nsv7676CNV Loss18451855
    nsv832063CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604673    OMIM disorders: --

    1 disease for MRVI1:    
    About MalaCards
    myeloid leukemia


    Find genes that share disorders with MRVI1           About GenesLikeMe

    Genetic Association Database (GAD): MRVI1
    Human Genome Epidemiology (HuGE) Navigator: MRVI1 (3 documents)

    Export disorders for MRVI1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRVI1 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with MRVI1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mrvi1, a common MRV integration site in BXH2 myeloid leukemias, encodes a protein with homology to a lymphoid-restricted membrane protein Jaw1. (PubMed id 10321731)1, 2, 3 Shaughnessy J.D. Jr.... Copeland N.G. (Oncogene 1999)
    2. InsP3R-associated cGMP kinase substrate (IRAG) is essential for nitric oxide-induced inhibition of calcium signaling in human colonic smooth muscle. (PubMed id 14729908)1, 2, 9 Fritsch R.M.... Allescher H.-D. (J. Biol. Chem. 2004)
    3. Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. (PubMed id 20526338)1, 4 Johnson A.D....Becker L.C. (Nat. Genet. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Inherited genetic variant predisposes to aggressive but not indolent prostate cancer. (PubMed id 20080650)1, 4 Xu J....Isaacs W.B. (Proc. Natl. Acad. Sci. U.S.A. 2010)
    6. IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation. (PubMed id 16990611)1, 2 Antl M.... Schlossmann J. (Blood 2007)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Association of phospholamban with a cGMP kinase signaling complex. (PubMed id 12480535)1, 9 Koller A....Hofmann F. (Biochem. Biophys. Res. Commun. 2003)
    9. Genome-wide meta-analysis identifies new susceptibility loci for migraine. (PubMed id 23793025)1 Anttila V.... . (Nat. Genet. 2013)
    10. Signaling via IRAG is essential for NO/cGMP-dependent inhibition of platelet activation. (PubMed id 21244222)1 Schinner E....Schlossmann J. (Platelets 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10335 HGNC: 7237 AceView: MRVI1 Ensembl:ENSG00000072952 euGenes: HUgn10335
    ECgene: MRVI1 Kegg: 10335 H-InvDB: MRVI1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRVI1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for MRVI1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MRVI1 gene:
    Search GeneIP for patents involving MRVI1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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