MRTO4 Gene
protein-coding GIFtS: 47
GCID: GC01P019578
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mRNA turnover 4 homolog (S. cerevisiae)(Previous names: chromosome 1 open reading frame 33, MRT4, mRNA turnover...) (Previous symbol: C1orf33)
| |
Aliases for MRTO4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| MRNA Turnover 4 Homolog (S. Cerevisiae)1 2 | | MRT4, MRNA Turnover 4, Homolog (S. Cerevisiae)1 | | C1orf331 2 3 | | 60S Acidic Ribosomal Protein PO2 | | MRT41 2 3 | | MRNA Turnover Protein 4 Homolog2 | | DJ657E11.41 | | MRT4, MRNA Turnover 4, Homolog2 | | Chromosome 1 Open Reading Frame 331 | | |
Export aliases for MRTO4 gene to outside databasesPrevious GC identifers: GC01P019451 GC01P017824 |
Summaries for MRTO4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for MRTO4: This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the precisefunction of the encoded protein is currently unknown, it appears to be involved in mRNA turnover and ribosomeassembly. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: MRT4_HUMAN, Q9UKD2Function: Involved in mRNA turnover and ribosome assembly (By similarity)
|
Genomic Views for MRTO4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MRTO4 gene promoter: p53 AML1a POU3F2 Cdc5 GATA-1 c-Ets-1 Zic1 ZID NF-kappaB1 Other transcription factors
Search SABiosciences Chromatin IP Primers for MRTO4
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRTO4 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.13 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36.13MRTO4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P019578: view genomic region
(about GC identifiers)
Start:
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19,578,033 bp from pter |
End:
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19,586,622 bp from pter |
Size:
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8,590 bases |
Orientation:
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plus strand |
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Proteins for MRTO4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: MRT4_HUMAN, Q9UKD2 (See
protein sequence)Recommended Name: mRNA turnover protein 4 homolog Size: 239 amino acids; 27560 Da
Subcellular location: Nucleus, nucleolus
Secondary accessions: B3KNB3 Q5TG55 Q96SS6 Q9BPV9Explore the universe of human proteins at neXtProt for MRTO4: NX_Q9UKD2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UKD2 MRTO4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057267.2 ENSEMBL proteins: ENSP00000364320 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MRTO4 for ontologies About GeneDecksing
MRTO4 Antibody Products: Assay Products for MRTO4: |
Protein
Domains / Families for MRTO4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRTO4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UKD2ProtoNet protein and cluster: Q9UKD2 UniProtKB/Swiss-Prot: MRT4_HUMAN, Q9UKD2Similarity: Belongs to the ribosomal protein L10P family |
Function for MRTO4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: MRT4_HUMAN, Q9UKD2Function: Involved in mRNA turnover and ribosome assembly (By similarity)
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRTO4 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRTO4 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRTO4 (NM_016183) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRTO4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRTO4  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRTO4 |
1 GenomeRNAi human phenotype for MRTO4:
|
Pathways & Interactions for MRTO4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRTO4
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/216 Interacting proteins for MRTO4 (Q9UKD23 ENSP000003643204) via UniProtKB, MINT, STRING, and/or I2D (see all 216)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0042254 | ribosome biogenesis |
IEA | -- |
MRTO4 for ontologies About GeneDecksing
|
Drugs & Compounds for MRTO4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for MRTO4 Search CenterWatch for drugs/clinical trials and news about MRTO4 / MRT4 
|
Transcripts for MRTO4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for MRTO4 gene: NM_016183.3 Unigene Cluster for MRTO4: MRNA turnover 4 homolog (S. cerevisiae) Hs.463797 [show with all ESTs]Unigene Representative Sequence: AK1263873 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000330263(uc001bbs.3) ENST00000493700 ENST00000479559
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRTO4 OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRTO4 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRTO4 (NM_016183) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRTO4 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRTO4  |
Additional cDNA sequence: AF173378.1 AK024227.1 AK027569.1 AK126387.1 AK295328.1 AY303790.1 BC003013.1 BC006504.2 10 DOTS entries: DT.100036348 DT.210276 DT.100785242 DT.95371777 DT.101972759 DT.92440260 DT.97798691 DT.92440262 DT.95347831 DT.95209428 24/231 AceView cDNA sequences (see all 231): BM841874 BU145603 BM760674 BM833066 BU739993 AI160726 BQ670859 BM999389 BE901149 BQ925818 BM760518 BQ226486 BU156881 AY303790 AA460896 CB124479 BU148551 BM841585 CA433275 AW451915 BE388616 BM675167 BM782081 BE560075 GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MRTO4 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | |
| SP1: | |   | |   | - |   | |   | |   | - |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | - |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for MRTO4
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Expression for MRTO4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRTO4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: ATGGGCACTG
About this image See MRTO4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MRTO4
SOURCE GeneReport for Unigene cluster: Hs.463797 SABiosciences Custom PCR Arrays for MRTO4
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRTO4 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRTO4 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRTO4 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRTO4 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRTO4 |
Orthologs for MRTO4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MRTO4 gene from 8/35 species (see all 35) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
chicken (Gallus gallus) |
Aves |
MRTO41 |
mRNA turnover 4 homolog (S. cerevisiae) |
74.09(n) 77.73(a) |
  |
428192 XM_425751.3 XP_425751.1 |
African clawed frog (Xenopus laevis) |
Amphibia |
MGC689202 |
hypothetical protein MGC68920 |
76.24(n) |
  |
BC056008.1 |
zebrafish (Danio rerio) |
Actinopterygii |
mrto41 |
mRNA turnover 4 homolog (S. cerevisiae) |
70.15(n) 70.29(a) |
  |
550350 NM_001017657.1 NP_001017657.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
RpLP0-like1 |
Ribosomal protein LP0-like |
58.72(n) 55.65(a) |
  |
36058 NM_136710.3 NP_610554.1 |
worm (Caenorhabditis elegans) |
Secernentea |
F10E7.51 |
Protein F10E7.5 |
54.62(n) 52.11(a) |
  |
174168 NM_063069.2 NP_495470.1 |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes |
MRT4(YKL009W)4 MRT41 |
Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus less4 Mrt4p1 |
47.17(n)1 41.98(a)1 |
  |
11(426242-426952)4 8538601, 4 NP_012916.11, 4 |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
AT1G252601 |
Ribosomal protein L10 family protein |
51.22(n) 45.06(a) |
  |
839109 NM_102335.3 NP_564226.1 |
rice (Oryza sativa) |
Liliopsida |
Os11g01054001 |
hypothetical protein |
50.51(n) 44.59(a) |
  |
4349548 NM_001072064.1 NP_001065532.1 |
Species with no ortholog for MRTO4
ENSEMBL Gene Tree for MRTO4 (if available) TreeFam Gene Tree for MRTO4 (if available)  |
Paralogs for MRTO4 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for MRTO4 gene
MRTO4 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for MRTO4 PGOHUM00000237431 PGOHUM00000234866
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Genomic Variants for MRTO4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 1 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for MRTO4 (19578033 - 19586622 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MRTO4: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRTO4 |
|
Disorders
/ Diseases for MRTO4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRTO4 for disorders About GeneDecksing
1 disease for MRTO4: About MalaCardsmalaria Human Genome Epidemiology (HuGE) Navigator: MRTO4 (1 document) Export disorders for MRTO4 gene to outside databases
|
Publications for MRTO4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRTO4 gene, integrated from 9 sources (see all 27): (articles sorted by number of sources associating them with MRTO4) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
- Subcellular localization of ribosomal P0-like protein MRT4 is determined by its N-terminal domain. (PubMed id 20083226)1, 9 Michalec B....TchA^rzewski M. (2010)
- Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
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External Searches for MRTO4 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing MRTO4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRTO4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRTO4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for MRTO4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRTO4 gene: Search GeneIP for patents involving MRTO4
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for MRTO4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRTO4 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRTO4 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRTO4 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRTO4 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRTO4 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRTO4 |
| |
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| |  |  |  |  | | | | | Recombinant Protein for MRTO4 |
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 | | MRTO4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRTO4 |
|  |  |  | | | Search ThermoFisher Antibodies for MRTO4 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRTO4 |
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