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Aliases for MRTO4 Gene

Aliases for MRTO4 Gene

  • MRNA Turnover 4 Homolog (S. Cerevisiae) 2 3
  • Ribosome Assembly Factor MRTO4 3 4
  • C1orf33 3 4
  • MRT4 3 4
  • MRT4, MRNA Turnover 4, Homolog (S. Cerevisiae) 2
  • Chromosome 1 Open Reading Frame 33 2
  • 60S Acidic Ribosomal Protein PO 3
  • MRNA Turnover Protein 4 Homolog 3
  • MRT4, MRNA Turnover 4, Homolog 3
  • DJ657E11.4 3

External Ids for MRTO4 Gene

Previous Symbols for MRTO4 Gene

  • C1orf33

Summaries for MRTO4 Gene

Entrez Gene Summary for MRTO4 Gene

  • This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the precise function of the encoded protein is currently unknown, it appears to be involved in mRNA turnover and ribosome assembly. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRTO4 Gene

MRTO4 (MRNA Turnover 4 Homolog (S. Cerevisiae)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MRTO4 Gene

  • Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRTO4 Gene

Genomics for MRTO4 Gene

Genomic Location for MRTO4 Gene

Start:
19,251,539 bp from pter
End:
19,260,128 bp from pter
Size:
8,590 bases
Orientation:
Plus strand

Genomic View for MRTO4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRTO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRTO4 Gene

Regulatory Elements for MRTO4 Gene

Proteins for MRTO4 Gene

  • Protein details for MRTO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKD2-MRT4_HUMAN
    Recommended name:
    mRNA turnover protein 4 homolog
    Protein Accession:
    Q9UKD2
    Secondary Accessions:
    • B3KNB3
    • Q5TG55
    • Q96SS6
    • Q9BPV9

    Protein attributes for MRTO4 Gene

    Size:
    239 amino acids
    Molecular mass:
    27560 Da
    Quaternary structure:
    • Associates with the pre-60S ribosomal particle.

neXtProt entry for MRTO4 Gene

Proteomics data for MRTO4 Gene at MOPED

Post-translational modifications for MRTO4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRTO4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRTO4 Gene

Domains for MRTO4 Gene

Protein Domains for MRTO4 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

MRT4_HUMAN
Family:
  • Belongs to the ribosomal protein L10P family.:
    • Q9UKD2
genes like me logo Genes that share domains with MRTO4: view

No data available for Gene Families for MRTO4 Gene

Function for MRTO4 Gene

Molecular function for MRTO4 Gene

UniProtKB/Swiss-Prot Function: Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.

Gene Ontology (GO) - Molecular Function for MRTO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRTO4: view

Phenotypes for MRTO4 Gene

GenomeRNAi human phenotypes for MRTO4:
genes like me logo Genes that share phenotypes with MRTO4: view

miRNA for MRTO4 Gene

miRTarBase miRNAs that target MRTO4

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRTO4 Gene

Localization for MRTO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRTO4 Gene

Nucleus, nucleolus. Cytoplasm. Note=Shutles between the nucleus and the cytoplasm. {ECO:0000269 PubMed:20083226}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRTO4 Gene COMPARTMENTS Subcellular localization image for MRTO4 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MRTO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MRTO4: view

Pathways for MRTO4 Gene

SuperPathways for MRTO4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRTO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with MRTO4: view

No data available for Pathways by source for MRTO4 Gene

Transcripts for MRTO4 Gene

mRNA/cDNA for MRTO4 Gene

Unigene Clusters for MRTO4 Gene

MRNA turnover 4 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRTO4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for MRTO4 Gene

GeneLoc Exon Structure for
MRTO4
ECgene alternative splicing isoforms for
MRTO4

Expression for MRTO4 Gene

mRNA expression in normal human tissues for MRTO4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRTO4 Gene

SOURCE GeneReport for Unigene cluster for MRTO4 Gene Hs.463797

genes like me logo Genes that share expressions with MRTO4: view

Orthologs for MRTO4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRTO4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRTO4 36
  • 99.86 (n)
  • 100 (a)
MRTO4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRTO4 36
  • 91.33 (n)
  • 96.86 (a)
MRTO4 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 87 (a)
OneToMany
-- 37
  • 94 (a)
OneToMany
-- 37
  • 72 (a)
OneToMany
MRTO4 36
  • 92.97 (n)
  • 95.52 (a)
mouse
(Mus musculus)
Mammalia Mrto4 36
  • 90.69 (n)
  • 95.5 (a)
Mrto4 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRTO4 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRTO4 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrto4 36
  • 89.39 (n)
  • 95.45 (a)
chicken
(Gallus gallus)
Aves MRTO4 36
  • 76.92 (n)
  • 82.35 (a)
MRTO4 37
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68920 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mrto4 36
  • 74.06 (n)
  • 78.28 (a)
Str.1618 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.186 36
zebrafish
(Danio rerio)
Actinopterygii mrto4 36
  • 71.95 (n)
  • 75.11 (a)
mrto4 37
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007644 36
  • 60.25 (n)
  • 53.05 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpLP0-like 36
  • 59.31 (n)
  • 57.21 (a)
RpLP0-like 37
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F10E7.5 36
  • 54.62 (n)
  • 52.11 (a)
F10E7.5 37
  • 50 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR012C 36
  • 50.46 (n)
  • 38.99 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRT4 36
  • 46.76 (n)
  • 41.2 (a)
MRT4 37
  • 38 (a)
OneToOne
MRT4 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13563g 36
  • 49.25 (n)
  • 37.84 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G25260 36
  • 52.72 (n)
  • 47.6 (a)
rice
(Oryza sativa)
Liliopsida Os11g0105400 36
  • 51.9 (n)
  • 47.14 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07547 36
  • 53.82 (n)
  • 44.95 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mrt4 36
  • 51.96 (n)
  • 50.49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4712 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1757 37
  • 49 (a)
OneToOne
Species with no ortholog for MRTO4:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRTO4 Gene

ENSEMBL:
Gene Tree for MRTO4 (if available)
TreeFam:
Gene Tree for MRTO4 (if available)

Paralogs for MRTO4 Gene

Pseudogenes.org Pseudogenes for MRTO4 Gene

genes like me logo Genes that share paralogs with MRTO4: view

No data available for Paralogs for MRTO4 Gene

Variants for MRTO4 Gene

Sequence variations from dbSNP and Humsavar for MRTO4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs735025 -- 19,255,049(-) GAGTA(C/T)GAGCT intron-variant
rs735026 -- 19,254,732(-) ATGCA(C/T)TGGAG intron-variant
rs761305 -- 19,259,051(-) TCTCC(C/T)GACCT utr-variant-3-prime
rs761306 -- 19,255,221(-) CCACC(A/G)TTCCT intron-variant
rs761307 -- 19,255,194(-) ACATT(A/G)GGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRTO4 Gene

Variant ID Type Subtype PubMed ID
nsv470702 CNV Gain 18288195
nsv871933 CNV Loss 21882294

Relevant External Links for MRTO4 Gene

HapMap Linkage Disequilibrium report
MRTO4

Disorders for MRTO4 Gene

Relevant External Links for MRTO4

Genetic Association Database (GAD)
MRTO4
Human Genome Epidemiology (HuGE) Navigator
MRTO4
genes like me logo Genes that share disorders with MRTO4: view

No data available for UniProtKB/Swiss-Prot for MRTO4 Gene

Publications for MRTO4 Gene

  1. Subcellular localization of ribosomal P0-like protein MRT4 is determined by its N-terminal domain. (PMID: 20083226) Michalec B. … TchA^rzewski M. (Int. J. Biochem. Cell Biol. 2010) 3 4 23
  2. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for MRTO4 Gene

Sources for MRTO4 Gene

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