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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRTO4 Gene

protein-coding   GIFtS: 49
GCID: GC01P019578

MRNA Turnover 4 Homolog (S. Cerevisiae)

(Previous names: chromosome 1 open reading frame 33, MRT4, mRNA turnover...)
(Previous symbol: C1orf33)
  Search for MRTO4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
MRNA Turnover 4 Homolog (S. Cerevisiae)1 2     60S Acidic Ribosomal Protein PO2
C1orf331 2 3     dJ657E11.42
MRT42 3     MRNA Turnover Protein 4 Homolog2
Chromosome 1 Open Reading Frame 331     MRT4, MRNA Turnover 4, Homolog2
MRT4, MRNA Turnover 4, Homolog (S. Cerevisiae)1     

External Ids:    HGNC: 184771   Entrez Gene: 511542   Ensembl: ENSG000000533727   UniProtKB: Q9UKD23   

Export aliases for MRTO4 gene to outside databases

Previous GC identifers: GC01P019451 GC01P017824


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRTO4 Gene:
This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the
precise function of the encoded protein is currently unknown, it appears to be involved in mRNA turnover and
ribosome assembly. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRTO4 Gene: 
MRTO4 (mRNA turnover 4 homolog (S. cerevisiae)) is a protein-coding gene.

UniProtKB/Swiss-Prot: MRT4_HUMAN, Q9UKD2
Function: Involved in mRNA turnover and ribosome assembly (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRTO4 gene promoter:
         p53   AML1a   POU3F2   Cdc5   GATA-1   c-Ets-1   Zic1   ZID   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRTO4 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRTO4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRTO4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

MRTO4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRTO4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P019578:  view genomic region     (about GC identifiers)

Start:
19,578,033 bp from pter      End:
19,586,622 bp from pter
Size:
8,590 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: MRT4_HUMAN, Q9UKD2 (See protein sequence)
Recommended Name: mRNA turnover protein 4 homolog  
Size: 239 amino acids; 27560 Da
Subcellular location: Nucleus, nucleolus
Secondary accessions: B3KNB3 Q5TG55 Q96SS6 Q9BPV9

Explore the universe of human proteins at neXtProt for MRTO4: NX_Q9UKD2

Explore proteomics data for MRTO4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UKD2

  • MRTO4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MRTO4 Protein Expression
    REFSEQ proteins: NP_057267.2  
    ENSEMBL proteins: 
     ENSP00000364320  

    Human Recombinant Protein Products for MRTO4: 
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    Sino Biological Recombinant Protein for MRTO4
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    ProSpec Recombinant Protein for MRTO4
    Cloud-Clone Corp. Proteins for MRTO4 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0031965nuclear membrane IDA--

    MRTO4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR001790 Ribosomal_L10/acidic_P0

    Graphical View of Domain Structure for InterPro Entry Q9UKD2

    ProtoNet protein and cluster: Q9UKD2

    UniProtKB/Swiss-Prot: MRT4_HUMAN, Q9UKD2
    Similarity: Belongs to the ribosomal protein L10P family


    MRTO4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRT4_HUMAN, Q9UKD2
    Function: Involved in mRNA turnover and ribosome assembly (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for MRTO4:

     Nuclear 60S biogenesis defects 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MRTO4 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRTO4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/228 Interacting proteins for MRTO4 (Q9UKD23 ENSP000003643204) via UniProtKB, MINT, STRING, and/or I2D (see all 228)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX39BQ138383I2D: score=1 
    ENSG00000215425Q138383I2D: score=1 
    ENSG00000225073Q138383I2D: score=1 
    ENSG00000225859Q138383I2D: score=1 
    ENSG00000229496Q138383I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042254ribosome biogenesis IEA--

    MRTO4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRTO4 (MRT4)

    Search CenterWatch for drugs/clinical trials and news about MRTO4 / MRT4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRTO4 gene: 
    NM_016183.3  

    Unigene Cluster for MRTO4:

    MRNA turnover 4 homolog (S. cerevisiae)
    Hs.463797  [show with all ESTs]
    Unigene Representative Sequence: AK126387
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330263(uc001bbs.3) ENST00000493700 ENST00000479559
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MRTO4:
    hsa-miR-545 hsa-miR-626
    SwitchGear 3'UTR luciferase reporter plasmidMRTO4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Additional mRNA sequence: 

    AF173378.1 AK024227.1 AK027569.1 AK126387.1 AK295328.1 AY303790.1 BC003013.1 BC006504.2 

    10 DOTS entries:

    DT.100036348  DT.210276  DT.100785242  DT.95371777  DT.101972759  DT.92440260  DT.97798691  DT.92440262 
    DT.95347831  DT.95209428 

    24/231 AceView cDNA sequences (see all 231):

    BM760674 BM999389 BM760518 BU739993 BM675167 AI160726 BM841874 BM841585 
    CA433275 BE388616 BU145603 BM833066 BU156881 BU148551 AA460896 BE901149 
    AW451915 CB124479 BQ925818 AY303790 BQ670859 BQ226486 BM782081 BG170641 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MRTO4 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:              -                 -           -           -                           
    SP2:              -                 -           -           -     -                     
    SP3:              -                 -                                                   
    SP4:                                -                                                   
    SP5:                                                                                    


    ECgene alternative splicing isoforms for MRTO4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRTO4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGGCACTG
    MRTO4 Expression
    About this image


    See MRTO4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRTO4

    SOURCE GeneReport for Unigene cluster: Hs.463797
        SABiosciences Custom PCR Arrays for MRTO4
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRTO4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MRTO4 gene from 8/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves MRTO41 mRNA turnover 4 homolog (S. cerevisiae) 74.09(n)
    77.73(a)
      428192  XM_425751.3  XP_425751.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC689202 hypothetical protein MGC68920 76.24(n)    BC056008.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mrto41 mRNA turnover 4 homolog (S. cerevisiae) 70.15(n)
    70.29(a)
      550350  NM_001017657.1  NP_001017657.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RpLP0-like1 Ribosomal protein LP0-like 58.72(n)
    55.65(a)
      36058  NM_136710.3  NP_610554.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F10E7.51 Protein F10E7.5 54.62(n)
    52.11(a)
      174168  NM_063069.2  NP_495470.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MRT4(YKL009W)4
    MRT41
    Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus less4
    Mrt4p1
    47.17(n)1
    41.98(a)1
      11(426242-426952)4
    8538601, 4  NP_012916.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G252601 Ribosomal protein L10 family protein 51.22(n)
    45.06(a)
      839109  NM_102335.3  NP_564226.1 
    rice
    (Oryza sativa)
    Liliopsida Os11g01054001 hypothetical protein 50.51(n)
    44.59(a)
      4349548  NM_001072064.1  NP_001065532.1 
            Species with no ortholog for MRTO4

    ENSEMBL Gene Tree for MRTO4 (if available)
    TreeFam Gene Tree for MRTO4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRTO4 gene

    MRTO4 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MRTO4
    PGOHUM00000237431 PGOHUM00000234866


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/208 SNPs in MRTO4 are shown (see all 208)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs801959301,2
    C,F--19580062(+) GGGCAG/AGAATG 1 -- int12Minor allele frequency- A:0.05NA EA 240
    rs109172781,2
    F--19580288(+) GAAGGC/TGCCCG 1 -- int11Minor allele frequency- T:0.05WA 118
    rs17380181,2
    C,F,A--19580305(-) CTCCAA/TCTGCA 1 -- int15Minor allele frequency- T:0.26WA CSA NA 243
    rs1810234621,2
    C--19580342(+) TGATTC/GTGTGG 1 -- int10--------
    rs1441854051,2
    C--19580460(+) GCTGCA/GTCTTT 1 -- int10--------
    rs793927561,2
    F--19580524(+) AGCCTC/TATGGT 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1486524661,2
    C--19580579(+) GAGCAA/GCAAGG 1 -- int10--------
    rs746163381,2
    C,F--19580625(+) ACTTTG/AGGAGA 1 -- int12Minor allele frequency- A:0.10WA NA 238
    rs9475291,2
    C,F,A--19580683(+) gcaacA/Gtggca 1 -- int15Minor allele frequency- G:0.27WA CSA NA 243
    rs1444371381,2
    --19580687(+) CATGGC/TAAAAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for MRTO4 (19578033 - 19586622 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MRTO4:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv871933CNV Loss21882294
    nsv470702CNV Gain18288195

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MRTO4 for disorders           About MalaCards

    MRTO4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRTO4
    Human Genome Epidemiology (HuGE) Navigator: MRTO4 (1 document)

    Export disorders for MRTO4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRTO4 gene, integrated from 9 sources (see all 29):
    (articles sorted by number of sources associating them with MRTO4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    6. Subcellular localization of ribosomal P0-like protein MRT4 is determined by its N-terminal domain. (PubMed id 20083226)1, 9 Michalec B....TchA^rzewski M. (2010)
    7. Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
    10. Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). (PubMed id 21907836)1 Zhao J....Yang P. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51154 HGNC: 18477 AceView: C1orf33 Ensembl:ENSG00000053372 euGenes: HUgn51154
    ECgene: MRTO4 H-InvDB: MRTO4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRTO4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MRTO4 gene:
    Search GeneIP for patents involving MRTO4

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