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Aliases for MRTO4 Gene

Aliases for MRTO4 Gene

  • MRT4 Homolog, Ribosome Maturation Factor 2 3 5
  • Ribosome Assembly Factor MRTO4 3 4
  • C1orf33 3 4
  • MRT4 3 4
  • MRT4, MRNA Turnover 4, Homolog (S. Cerevisiae) 2
  • MRNA Turnover 4 Homolog (S. Cerevisiae) 2
  • Chromosome 1 Open Reading Frame 33 2
  • MRTO4 Ribosome Maturation Factor 3
  • 60S Acidic Ribosomal Protein PO 3
  • MRNA Turnover Protein 4 Homolog 3
  • MRT4, MRNA Turnover 4, Homolog 3
  • MRNA Turnover 4 Homolog 3
  • DJ657E11.4 3

External Ids for MRTO4 Gene

Previous HGNC Symbols for MRTO4 Gene

  • C1orf33

Previous GeneCards Identifiers for MRTO4 Gene

  • GC01P019451
  • GC01P019578
  • GC01P017824

Summaries for MRTO4 Gene

Entrez Gene Summary for MRTO4 Gene

  • This gene encodes a protein sharing a low level of sequence similarity with ribosomal protein P0. While the precise function of the encoded protein is currently unknown, it appears to be involved in mRNA turnover and ribosome assembly. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRTO4 Gene

MRTO4 (MRT4 Homolog, Ribosome Maturation Factor) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for MRTO4 Gene

  • Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRTO4 Gene

Genomics for MRTO4 Gene

Regulatory Elements for MRTO4 Gene

Enhancers for MRTO4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G019250 1.2 ENCODE 17.3 +0.6 617 3.2 HDGF HNRNPUL1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 MRTO4 EMC1 GC01M019261
GH01G019260 1.2 Ensembl ENCODE dbSUPER 12.1 +9.2 9196 1.3 SMAD5 BHLHE40 ZIC2 ZFHX2 POLR2A MYNN FOS ZBTB33 ZNF600 MAFK MRTO4 EMC1 GC01M019261
GH01G019268 1.1 dbSUPER 8.9 +18.3 18332 2.8 HDGF FOXA2 PKNOX1 ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 FEZF1 MRTO4 EMC1 AKR7L GC01M019261
GH01G019271 1 ENCODE dbSUPER 8.4 +22.0 21999 3.4 ZMYM3 MAX RAD21 ZNF507 YY1 GATA2 HNF4G NR2F1 CEBPB ELF1 RNU6-1099P AKR7A2 PQLC2 TAS1R2 MRTO4 AKR7A3 ENSG00000272084 AKR7L GC01M019261
GH01G019639 1.4 Ensembl ENCODE dbSUPER 5 +389.1 389070 1.4 TBP PKNOX1 NFIB SIN3A ZNF48 RARA RFX5 GLIS2 RCOR1 MIXL1 MRTO4 AKR7A2 NBL1 GC01M019654
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRTO4 on UCSC Golden Path with GeneCards custom track

Promoters for MRTO4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000002419 261 2001 HDGF HNRNPUL1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for MRTO4 Gene

Chromosome:
1
Start:
19,251,539 bp from pter
End:
19,260,128 bp from pter
Size:
8,590 bases
Orientation:
Plus strand

Genomic View for MRTO4 Gene

Genes around MRTO4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRTO4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRTO4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRTO4 Gene

Proteins for MRTO4 Gene

  • Protein details for MRTO4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKD2-MRT4_HUMAN
    Recommended name:
    mRNA turnover protein 4 homolog
    Protein Accession:
    Q9UKD2
    Secondary Accessions:
    • B3KNB3
    • Q5TG55
    • Q96SS6
    • Q9BPV9

    Protein attributes for MRTO4 Gene

    Size:
    239 amino acids
    Molecular mass:
    27560 Da
    Quaternary structure:
    • Associates with the pre-60S ribosomal particle.

neXtProt entry for MRTO4 Gene

Post-translational modifications for MRTO4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRTO4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRTO4 Gene

Domains & Families for MRTO4 Gene

Protein Domains for MRTO4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRTO4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UKD2

UniProtKB/Swiss-Prot:

MRT4_HUMAN :
  • Belongs to the universal ribosomal protein uL10 family.
Family:
  • Belongs to the universal ribosomal protein uL10 family.
genes like me logo Genes that share domains with MRTO4: view

No data available for Gene Families for MRTO4 Gene

Function for MRTO4 Gene

Molecular function for MRTO4 Gene

UniProtKB/Swiss-Prot Function:
Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.

Gene Ontology (GO) - Molecular Function for MRTO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with MRTO4: view
genes like me logo Genes that share phenotypes with MRTO4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRTO4 Gene

Localization for MRTO4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRTO4 Gene

Nucleus, nucleolus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269 PubMed:20083226}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRTO4 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MRTO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005730 nucleolus IBA,IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MRTO4: view

Pathways & Interactions for MRTO4 Gene

SuperPathways for MRTO4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRTO4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000027 ribosomal large subunit assembly IBA --
GO:0000956 nuclear-transcribed mRNA catabolic process IBA --
GO:0006364 rRNA processing IBA --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with MRTO4: view

No data available for Pathways by source and SIGNOR curated interactions for MRTO4 Gene

Drugs & Compounds for MRTO4 Gene

No Compound Related Data Available

Transcripts for MRTO4 Gene

Unigene Clusters for MRTO4 Gene

MRNA turnover 4 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRTO4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for MRTO4 Gene

GeneLoc Exon Structure for
MRTO4
ECgene alternative splicing isoforms for
MRTO4

Expression for MRTO4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRTO4 Gene

Protein differential expression in normal tissues from HIPED for MRTO4 Gene

This gene is overexpressed in Lung (29.6) and Islet of Langerhans (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRTO4 Gene



Protein tissue co-expression partners for MRTO4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRTO4 Gene:

MRTO4

SOURCE GeneReport for Unigene cluster for MRTO4 Gene:

Hs.463797

Evidence on tissue expression from TISSUES for MRTO4 Gene

  • Lung(4.2)
  • Nervous system(2.6)
genes like me logo Genes that share expression patterns with MRTO4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRTO4 Gene

Orthologs for MRTO4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRTO4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRTO4 34 35
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 94 (a)
OneToMany
MRTO4 34
  • 92.97 (n)
-- 35
  • 87 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MRTO4 34 35
  • 91.33 (n)
mouse
(Mus musculus)
Mammalia Mrto4 34 35
  • 90.69 (n)
Mrto4-ps2 16
rat
(Rattus norvegicus)
Mammalia Mrto4 34
  • 89.39 (n)
oppossum
(Monodelphis domestica)
Mammalia MRTO4 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRTO4 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRTO4 34 35
  • 76.92 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrto4 34
  • 74.06 (n)
Str.1618 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68920 34
zebrafish
(Danio rerio)
Actinopterygii mrto4 34 35
  • 71.95 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.186 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007644 34
  • 60.25 (n)
fruit fly
(Drosophila melanogaster)
Insecta RpLP0-like 35 34
  • 59.31 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F10E7.5 35 34
  • 54.62 (n)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR012C 34
  • 50.46 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B13563g 34
  • 49.25 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRT4 34 35 37
  • 46.76 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G25260 34
  • 52.72 (n)
rice
(Oryza sativa)
Liliopsida Os11g0105400 34
  • 51.9 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU07547 34
  • 53.82 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mrt4 34
  • 51.96 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1757 35
  • 49 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4712 34
Species where no ortholog for MRTO4 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRTO4 Gene

ENSEMBL:
Gene Tree for MRTO4 (if available)
TreeFam:
Gene Tree for MRTO4 (if available)

Paralogs for MRTO4 Gene

Pseudogenes.org Pseudogenes for MRTO4 Gene

genes like me logo Genes that share paralogs with MRTO4: view

No data available for Paralogs for MRTO4 Gene

Variants for MRTO4 Gene

Sequence variations from dbSNP and Humsavar for MRTO4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000261098 -- 19,252,229(+) CTGCC(A/T)TTCCC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000311749 -- 19,253,195(+) AAAGG(A/T)CTCAC intron-variant, upstream-variant-2KB
rs1000592160 -- 19,252,379(+) GTTGC(C/T)CAGGC intron-variant, upstream-variant-2KB
rs1001047817 -- 19,252,027(+) CTGTA(-/AAAC)CGCCA intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001198351 -- 19,258,730(+) ATACA(C/T)GTGGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MRTO4 Gene

Variant ID Type Subtype PubMed ID
nsv470702 CNV gain 18288195

Variation tolerance for MRTO4 Gene

Residual Variation Intolerance Score: 43.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRTO4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRTO4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRTO4 Gene

Disorders for MRTO4 Gene

Relevant External Links for MRTO4

Genetic Association Database (GAD)
MRTO4
Human Genome Epidemiology (HuGE) Navigator
MRTO4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRTO4

No disorders were found for MRTO4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRTO4 Gene

Publications for MRTO4 Gene

  1. Subcellular localization of ribosomal P0-like protein MRT4 is determined by its N-terminal domain. (PMID: 20083226) Michalec B. … TchA^rzewski M. (Int. J. Biochem. Cell Biol. 2010) 2 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MRTO4 Gene

Sources for MRTO4 Gene

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