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Aliases for MRS2 Gene

Aliases for MRS2 Gene

  • MRS2, Magnesium Transporter 2 3 5
  • MRS2-Like Protein 3 4
  • MRS2L 3 4
  • HPT 3 4
  • MRS2 Magnesium Homeostasis Factor Homolog (S. Cerevisiae) 2
  • MRS2-Like, Magnesium Homeostasis Factor (S. Cerevisiae) 2
  • Magnesium Transporter MRS2 Homolog, Mitochondrial 3
  • MRS2-Like, Magnesium Homeostasis Factor 3
  • Putative Magnesium Transporter 3

External Ids for MRS2 Gene

Previous HGNC Symbols for MRS2 Gene

  • MRS2L

Previous GeneCards Identifiers for MRS2 Gene

  • GC06P024512
  • GC06P024403
  • GC06P024352

Summaries for MRS2 Gene

GeneCards Summary for MRS2 Gene

MRS2 (MRS2, Magnesium Transporter) is a Protein Coding gene. Diseases associated with MRS2 include Basilar Artery Occlusion. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Miscellaneous transport and binding events. GO annotations related to this gene include magnesium ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for MRS2 Gene

  • Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).

Gene Wiki entry for MRS2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRS2 Gene

Genomics for MRS2 Gene

Regulatory Elements for MRS2 Gene

Enhancers for MRS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G024399 1.4 Ensembl ENCODE 38.3 -1.0 -975 5.3 HDGF PKNOX1 CREB3L1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 MRS2 ALDH5A1 DCDC2
GH06G024427 0.9 Ensembl ENCODE 47.6 +25.7 25738 1.4 PKNOX1 CEBPB MAFG EP300 MAFF ZFHX2 ZNF316 IKZF1 NFE2 EMSY MRS2 RNU6-391P PIR53932 ALDH5A1
GH06G024431 0.8 ENCODE 33.5 +28.3 28290 0.1 ELF3 HDAC1 CTCF CBX3 ARNT JUN ZSCAN9 RAD21 CBX5 ZNF143 MRS2 PIR53932 ALDH5A1
GH06G024359 1.3 Ensembl ENCODE 14.5 -42.6 -42634 1.4 ARNT SIN3A ZNF2 ZNF121 GLIS2 ZNF143 ZNF207 KLF7 ZNF202 SP3 MRS2 GC06P024361 KAAG1
GH06G024385 1.2 ENCODE dbSUPER 5.8 -17.1 -17103 0.8 HNRNPUL1 FOXA2 ATF1 MLX ARID4B DMAP1 ZNF48 SLC30A9 SP5 ZHX2 MRS2 DCDC2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRS2 on UCSC Golden Path with GeneCards custom track

Promoters for MRS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000194773 592 1801 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for MRS2 Gene

Chromosome:
6
Start:
24,402,908 bp from pter
End:
24,426,194 bp from pter
Size:
23,287 bases
Orientation:
Plus strand

Genomic View for MRS2 Gene

Genes around MRS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRS2 Gene

Proteins for MRS2 Gene

  • Protein details for MRS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD23-MRS2_HUMAN
    Recommended name:
    Magnesium transporter MRS2 homolog, mitochondrial
    Protein Accession:
    Q9HD23
    Secondary Accessions:
    • A8K4U3
    • B3KNN2
    • B4DQL2
    • Q5T3Y1
    • Q6NTG4
    • Q96KF8
    • Q9BVP1

    Protein attributes for MRS2 Gene

    Size:
    443 amino acids
    Molecular mass:
    50318 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Has the ability to complement a deletion of MRS2 in S.cerevisiae and partly restore mitochondrial magnesium concentrations.
    SequenceCaution:
    • Sequence=CAI17109.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MRS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRS2 Gene

Post-translational modifications for MRS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRS2 Gene

Domains & Families for MRS2 Gene

Protein Domains for MRS2 Gene

Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9HD23

UniProtKB/Swiss-Prot:

MRS2_HUMAN :
  • Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
Family:
  • Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
genes like me logo Genes that share domains with MRS2: view

No data available for Gene Families for MRS2 Gene

Function for MRS2 Gene

Molecular function for MRS2 Gene

UniProtKB/Swiss-Prot Function:
Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).

Gene Ontology (GO) - Molecular Function for MRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015095 magnesium ion transmembrane transporter activity TAS --
genes like me logo Genes that share ontologies with MRS2: view
genes like me logo Genes that share phenotypes with MRS2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRS2 Gene

Localization for MRS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRS2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRS2 gene
Compartment Confidence
mitochondrion 5
plasma membrane 2
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 11401429
GO:0005743 mitochondrial inner membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MRS2: view

Pathways & Interactions for MRS2 Gene

genes like me logo Genes that share pathways with MRS2: view

Pathways by source for MRS2 Gene

Gene Ontology (GO) - Biological Process for MRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006089 lactate metabolic process IEA --
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0045016 mitochondrial magnesium ion transport IBA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with MRS2: view

No data available for SIGNOR curated interactions for MRS2 Gene

Drugs & Compounds for MRS2 Gene

(1) Drugs for MRS2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0

(1) Additional Compounds for MRS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MRS2: view

Transcripts for MRS2 Gene

Unigene Clusters for MRS2 Gene

MRS2 magnesium homeostasis factor homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRS2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d · 12e ^ 13
SP1: - - - - -
SP2: - - -
SP3:
SP4: - - - - - - - -
SP5: - - -
SP6:
SP7: -

Relevant External Links for MRS2 Gene

GeneLoc Exon Structure for
MRS2
ECgene alternative splicing isoforms for
MRS2

Expression for MRS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRS2 Gene

Protein differential expression in normal tissues from HIPED for MRS2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (53.1) and Retina (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRS2 Gene



Protein tissue co-expression partners for MRS2 Gene

NURSA nuclear receptor signaling pathways regulating expression of MRS2 Gene:

MRS2

SOURCE GeneReport for Unigene cluster for MRS2 Gene:

Hs.658612

Evidence on tissue expression from TISSUES for MRS2 Gene

  • Lung(4.4)
  • Nervous system(3.7)
genes like me logo Genes that share expression patterns with MRS2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRS2 Gene

Orthologs for MRS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRS2 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia MRS2 34 35
  • 90.21 (n)
cow
(Bos Taurus)
Mammalia MRS2 34 35
  • 87.06 (n)
rat
(Rattus norvegicus)
Mammalia Mrs2 34
  • 83.33 (n)
mouse
(Mus musculus)
Mammalia Mrs2 34 16 35
  • 81.87 (n)
oppossum
(Monodelphis domestica)
Mammalia MRS2 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRS2 34 35
  • 75.3 (n)
lizard
(Anolis carolinensis)
Reptilia MRS2 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrs2 34
  • 72.61 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC565251 34
  • 67.16 (n)
MRS2 35
  • 59 (a)
OneToOne
Dr.22850 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5335 34
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F02519g 34
  • 43.56 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRS2 34 35
  • 43.26 (n)
MFM1 35 37
  • 23 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR359W 34
  • 41.16 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons MGT10 34
  • 42.14 (n)
rice
(Oryza sativa)
Liliopsida Os03g0684400 34
  • 43.38 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mrs2 34
  • 44.25 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09091 34
  • 42.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8669 35
  • 7 (a)
OneToOne
Species where no ortholog for MRS2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRS2 Gene

ENSEMBL:
Gene Tree for MRS2 (if available)
TreeFam:
Gene Tree for MRS2 (if available)

Paralogs for MRS2 Gene

Pseudogenes.org Pseudogenes for MRS2 Gene

genes like me logo Genes that share paralogs with MRS2: view

No data available for Paralogs for MRS2 Gene

Variants for MRS2 Gene

Sequence variations from dbSNP and Humsavar for MRS2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000313054 -- 24,410,612(+) GACCA(C/G)GAGTT intron-variant
rs1000426842 -- 24,404,819(+) TATGC(A/G)AAAAG intron-variant
rs1000475260 -- 24,404,644(+) TGGGG(G/T)TATTT intron-variant
rs1000499126 -- 24,416,929(+) TCTTA(C/T)AAACC intron-variant
rs1000671974 -- 24,417,418(+) GTGGA(-/TTTTG)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRS2 Gene

Variant ID Type Subtype PubMed ID
esv2671548 CNV deletion 23128226
nsv1026638 CNV gain 25217958
nsv1125872 CNV tandem duplication 24896259

Variation tolerance for MRS2 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.66; 78.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRS2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRS2 Gene

Disorders for MRS2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MRS2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
basilar artery occlusion
- elite association - COSMIC cancer census association via MalaCards
Search MRS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MRS2

Genetic Association Database (GAD)
MRS2
Human Genome Epidemiology (HuGE) Navigator
MRS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRS2
genes like me logo Genes that share disorders with MRS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRS2 Gene

Publications for MRS2 Gene

  1. The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter. (PMID: 11401429) Zsurka G. … Schweyen R.J. (Genomics 2001) 3 4 22 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Conditional knockdown of hMRS2 results in loss of mitochondrial Mg(2+) uptake and cell death. (PMID: 18384665) Piskacek M. … Schweyen R.J. (J. Cell. Mol. Med. 2009) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MRS2 Gene

Sources for MRS2 Gene

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