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Aliases for MRS2 Gene

Aliases for MRS2 Gene

  • MRS2, Magnesium Transporter 2 3 5
  • MRS2-Like Protein 3 4
  • MRS2L 3 4
  • HPT 3 4
  • MRS2 Magnesium Homeostasis Factor Homolog (S. Cerevisiae) 2
  • MRS2-Like, Magnesium Homeostasis Factor (S. Cerevisiae) 2
  • MRS2-Like, Magnesium Homeostasis Factor 3
  • Putative Magnesium Transporter 3
  • MRS2 Magnesium Transporter 3

External Ids for MRS2 Gene

Previous HGNC Symbols for MRS2 Gene

  • MRS2L

Previous GeneCards Identifiers for MRS2 Gene

  • GC06P024512
  • GC06P024403
  • GC06P024352

Summaries for MRS2 Gene

GeneCards Summary for MRS2 Gene

MRS2 (MRS2, Magnesium Transporter) is a Protein Coding gene. Diseases associated with MRS2 include Basilar Artery Occlusion and Akinetic Mutism. Among its related pathways are Miscellaneous transport and binding events and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include magnesium ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for MRS2 Gene

  • Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).

Gene Wiki entry for MRS2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRS2 Gene

Genomics for MRS2 Gene

Regulatory Elements for MRS2 Gene

Enhancers for MRS2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRS2 on UCSC Golden Path with GeneCards custom track

Promoters for MRS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRS2 Gene

Chromosome:
6
Start:
24,402,908 bp from pter
End:
24,426,194 bp from pter
Size:
23,287 bases
Orientation:
Plus strand

Genomic View for MRS2 Gene

Genes around MRS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRS2 Gene

Proteins for MRS2 Gene

  • Protein details for MRS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD23-MRS2_HUMAN
    Recommended name:
    Magnesium transporter MRS2 homolog, mitochondrial
    Protein Accession:
    Q9HD23
    Secondary Accessions:
    • A8K4U3
    • B3KNN2
    • B4DQL2
    • Q5T3Y1
    • Q6NTG4
    • Q96KF8
    • Q9BVP1

    Protein attributes for MRS2 Gene

    Size:
    443 amino acids
    Molecular mass:
    50318 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Has the ability to complement a deletion of MRS2 in S.cerevisiae and partly restore mitochondrial magnesium concentrations.
    SequenceCaution:
    • Sequence=CAI17109.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MRS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRS2 Gene

Proteomics data for MRS2 Gene at MOPED

Post-translational modifications for MRS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRS2 Gene

Domains & Families for MRS2 Gene

Protein Domains for MRS2 Gene

Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9HD23

UniProtKB/Swiss-Prot:

MRS2_HUMAN :
  • Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
Family:
  • Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
genes like me logo Genes that share domains with MRS2: view

No data available for Gene Families for MRS2 Gene

Function for MRS2 Gene

Molecular function for MRS2 Gene

UniProtKB/Swiss-Prot Function:
Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).
genes like me logo Genes that share phenotypes with MRS2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRS2 Gene

Localization for MRS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRS2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRS2 Gene COMPARTMENTS Subcellular localization image for MRS2 gene
Compartment Confidence
mitochondrion 5
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRS2: view

Pathways & Interactions for MRS2 Gene

genes like me logo Genes that share pathways with MRS2: view

Pathways by source for MRS2 Gene

Interacting Proteins for MRS2 Gene

Gene Ontology (GO) - Biological Process for MRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport TAS --
GO:1990614 mitochondrial magnesium ion transmembrane transport IMP 11401429
genes like me logo Genes that share ontologies with MRS2: view

No data available for SIGNOR curated interactions for MRS2 Gene

Drugs & Compounds for MRS2 Gene

(1) Drugs for MRS2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Magnesium Nutra 0

(1) Additional Compounds for MRS2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MRS2: view

Transcripts for MRS2 Gene

Unigene Clusters for MRS2 Gene

MRS2 magnesium homeostasis factor homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRS2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d · 12e ^ 13
SP1: - - - - -
SP2: - - -
SP3:
SP4: - - - - - - - -
SP5: - - -
SP6:
SP7: -

Relevant External Links for MRS2 Gene

GeneLoc Exon Structure for
MRS2
ECgene alternative splicing isoforms for
MRS2

Expression for MRS2 Gene

mRNA expression in normal human tissues for MRS2 Gene

Protein differential expression in normal tissues from HIPED for MRS2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (53.1) and Retina (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRS2 Gene



SOURCE GeneReport for Unigene cluster for MRS2 Gene Hs.658612

genes like me logo Genes that share expression patterns with MRS2: view

Protein tissue co-expression partners for MRS2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRS2 Gene

Orthologs for MRS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRS2 35
  • 87.06 (n)
  • 88.49 (a)
MRS2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRS2 35
  • 90.21 (n)
  • 93.12 (a)
MRS2 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrs2 35
  • 81.87 (n)
  • 84.56 (a)
Mrs2 16
Mrs2 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRS2 35
  • 99.55 (n)
  • 99.55 (a)
MRS2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrs2 35
  • 83.33 (n)
  • 86.18 (a)
oppossum
(Monodelphis domestica)
Mammalia MRS2 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRS2 35
  • 75.3 (n)
  • 77.66 (a)
MRS2 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRS2 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrs2 35
  • 72.61 (n)
  • 74.47 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.22850 35
LOC565251 35
  • 67.16 (n)
  • 70.71 (a)
MRS2 36
  • 59 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5335 35
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR359W 35
  • 41.16 (n)
  • 28.83 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F02519g 35
  • 43.56 (n)
  • 27.59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRS2 35
  • 43.26 (n)
  • 26.6 (a)
MFM1 36
  • 23 (a)
OneToMany
MRS2 36
  • 19 (a)
OneToMany
MFM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MGT10 35
  • 42.14 (n)
  • 28.3 (a)
rice
(Oryza sativa)
Liliopsida Os03g0684400 35
  • 43.38 (n)
  • 30.14 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09091 35
  • 42.65 (n)
  • 31.31 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mrs2 35
  • 44.25 (n)
  • 31.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8669 36
  • 7 (a)
OneToOne
Species with no ortholog for MRS2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRS2 Gene

ENSEMBL:
Gene Tree for MRS2 (if available)
TreeFam:
Gene Tree for MRS2 (if available)

Paralogs for MRS2 Gene

Pseudogenes.org Pseudogenes for MRS2 Gene

genes like me logo Genes that share paralogs with MRS2: view

No data available for Paralogs for MRS2 Gene

Variants for MRS2 Gene

Sequence variations from dbSNP and Humsavar for MRS2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2295651 - 24,403,149(+) GTCCT(C/G/T)CCGTT nc-transcript-variant, reference, missense
rs35261004 - 24,423,596(+) CTTTA(C/T)CTAAA nc-transcript-variant, downstream-variant-500B, reference, missense
rs1054862 -- 24,423,366(+) TCATA(A/G)CCAAA intron-variant, utr-variant-3-prime
rs1054868 -- 24,423,447(+) AGATG(A/G)CACCA intron-variant, utr-variant-3-prime
rs1056283 -- 24,420,148(+) CCACT(C/T)GTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRS2 Gene

Variant ID Type Subtype PubMed ID
esv2671548 CNV Deletion 23128226

Variation tolerance for MRS2 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.66; 78.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRS2 Gene

Disorders for MRS2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MRS2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
basilar artery occlusion
akinetic mutism
  • coma vigilans
middle cerebral artery infarction
  • infarction middle cerebral artery
- elite association - COSMIC cancer census association via MalaCards
Search MRS2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MRS2

Genetic Association Database (GAD)
MRS2
Human Genome Epidemiology (HuGE) Navigator
MRS2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRS2
genes like me logo Genes that share disorders with MRS2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRS2 Gene

Publications for MRS2 Gene

  1. The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter. (PMID: 11401429) Zsurka G. … Schweyen R.J. (Genomics 2001) 3 4 23 67
  2. EDD, a ubiquitin-protein ligase of the N-end rule pathway, associates with spindle assembly checkpoint components and regulates the mitotic response to nocodazole. (PMID: 25833949) Scialpi F. … Ditzel M. (J. Biol. Chem. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 3
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3

Products for MRS2 Gene

Sources for MRS2 Gene

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