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Aliases for MRS2 Gene

Aliases for MRS2 Gene

  • MRS2 Magnesium Transporter 2 3
  • MRS2-Like Protein 3 4
  • MRS2L 3 4
  • HPT 3 4
  • MRS2 Magnesium Homeostasis Factor Homolog (S. Cerevisiae) 2
  • MRS2-Like, Magnesium Homeostasis Factor (S. Cerevisiae) 2
  • Magnesium Transporter MRS2 Homolog, Mitochondrial 3
  • MRS2-Like, Magnesium Homeostasis Factor 3
  • PIGO 6
  • HP 6

External Ids for MRS2 Gene

Previous HGNC Symbols for MRS2 Gene

  • MRS2L

Previous GeneCards Identifiers for MRS2 Gene

  • GC06P024512
  • GC06P024403
  • GC06P024352

Summaries for MRS2 Gene

GeneCards Summary for MRS2 Gene

MRS2 (MRS2 Magnesium Transporter) is a Protein Coding gene. Diseases associated with MRS2 include hyperphosphatasia with mental retardation syndrome 2 and hyperphosphatasia with mental retardation syndrome. Among its related pathways are amb2 Integrin signaling and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include magnesium ion transmembrane transporter activity.

UniProtKB/Swiss-Prot for MRS2 Gene

  • Magnesium transporter that may mediate the influx of magnesium into the mitochondrial matrix.

Gene Wiki entry for MRS2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRS2 Gene

Genomics for MRS2 Gene

Regulatory Elements for MRS2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRS2 Gene

24,402,908 bp from pter
24,426,194 bp from pter
23,287 bases
Plus strand

Genomic View for MRS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRS2 Gene

Proteins for MRS2 Gene

  • Protein details for MRS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Magnesium transporter MRS2 homolog, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A8K4U3
    • B3KNN2
    • B4DQL2
    • Q5T3Y1
    • Q6NTG4
    • Q96KF8
    • Q9BVP1

    Protein attributes for MRS2 Gene

    443 amino acids
    Molecular mass:
    50318 Da
    Quaternary structure:
    No Data Available
    • Has the ability to complement a deletion of MRS2 in S.cerevisiae and partly restore mitochondrial magnesium concentrations
    • Sequence=CAI17109.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MRS2 Gene


neXtProt entry for MRS2 Gene

Proteomics data for MRS2 Gene at MOPED

Post-translational modifications for MRS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRS2 Gene

Domains for MRS2 Gene

Protein Domains for MRS2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q9HD23
  • Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.
genes like me logo Genes that share domains with MRS2: view

No data available for Gene Families for MRS2 Gene

Function for MRS2 Gene

Molecular function for MRS2 Gene

UniProtKB/Swiss-Prot Function:
Magnesium transporter that may mediate the influx of magnesium into the mitochondrial matrix.

Gene Ontology (GO) - Molecular Function for MRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015095 magnesium ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with MRS2: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRS2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRS2 Gene

Localization for MRS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRS2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MRS2 Gene COMPARTMENTS Subcellular localization image for MRS2 gene
Compartment Confidence
mitochondrion 5
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MRS2: view

Pathways for MRS2 Gene

genes like me logo Genes that share pathways with MRS2: view

Interacting Proteins for MRS2 Gene

Gene Ontology (GO) - Biological Process for MRS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015693 magnesium ion transport IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with MRS2: view

Compounds for MRS2 Gene

(1) HMDB Compounds for MRS2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Magnesium

(1) Novoseek inferred chemical compound relationships for MRS2 Gene

Compound -log(P) Hits PubMed IDs
hygromycin 77.4 2
genes like me logo Genes that share compounds with MRS2: view

Transcripts for MRS2 Gene

Unigene Clusters for MRS2 Gene

MRS2 magnesium homeostasis factor homolog (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRS2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRS2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d · 12e ^ 13
SP1: - - - - -
SP2: - - -
SP4: - - - - - - - -
SP5: - - -
SP7: -

Relevant External Links for MRS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRS2 Gene

mRNA expression in normal human tissues for MRS2 Gene

Protein differential expression in normal tissues for MRS2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (53.1) and Retina (13.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRS2 Gene

SOURCE GeneReport for Unigene cluster for MRS2 Gene Hs.658612

genes like me logo Genes that share expressions with MRS2: view

Expression partners for MRS2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRS2 Gene

Orthologs for MRS2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRS2 35
  • 87.06 (n)
  • 88.49 (a)
MRS2 36
  • 88 (a)
(Canis familiaris)
Mammalia MRS2 35
  • 90.21 (n)
  • 93.12 (a)
MRS2 36
  • 93 (a)
(Mus musculus)
Mammalia Mrs2 35
  • 81.87 (n)
  • 84.56 (a)
Mrs2 16
Mrs2 36
  • 76 (a)
(Pan troglodytes)
Mammalia MRS2 35
  • 99.55 (n)
  • 99.55 (a)
MRS2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrs2 35
  • 83.33 (n)
  • 86.18 (a)
(Monodelphis domestica)
Mammalia MRS2 36
  • 79 (a)
(Gallus gallus)
Aves MRS2 35
  • 75.3 (n)
  • 77.66 (a)
MRS2 36
  • 72 (a)
(Anolis carolinensis)
Reptilia MRS2 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrs2 35
  • 72.61 (n)
  • 74.47 (a)
(Danio rerio)
Actinopterygii Dr.22850 35
LOC565251 35
  • 67.16 (n)
  • 70.71 (a)
MRS2 36
  • 59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5335 35
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR359W 35
  • 41.16 (n)
  • 28.83 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F02519g 35
  • 43.56 (n)
  • 27.59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRS2 35
  • 43.26 (n)
  • 26.6 (a)
MFM1 36
  • 23 (a)
MRS2 36
  • 19 (a)
MFM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MGT10 35
  • 42.14 (n)
  • 28.3 (a)
(Oryza sativa)
Liliopsida Os03g0684400 35
  • 43.38 (n)
  • 30.14 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU09091 35
  • 42.65 (n)
  • 31.31 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes mrs2 35
  • 44.25 (n)
  • 31.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8669 36
  • 7 (a)
Species with no ortholog for MRS2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRS2 Gene

Gene Tree for MRS2 (if available)
Gene Tree for MRS2 (if available)

Paralogs for MRS2 Gene Pseudogenes for MRS2 Gene

genes like me logo Genes that share paralogs with MRS2: view

No data available for Paralogs for MRS2 Gene

Variants for MRS2 Gene

Sequence variations from dbSNP and Humsavar for MRS2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs11695 -- 24,403,227(+) GGCTC(C/T)GCGTG reference, missense, nc-transcript-variant
rs13735 -- 24,423,396(+) TATAA(C/T)GTTCT intron-variant, utr-variant-3-prime
rs793654 -- 24,404,106(-) CACAA(C/T)TGAGA intron-variant
rs793655 -- 24,402,718(+) CCAAG(C/G)GCCCA upstream-variant-2KB
rs793656 -- 24,402,524(+) ctcct(A/G)ctaat upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRS2 Gene

Variant ID Type Subtype PubMed ID
esv2671548 CNV Deletion 23128226

Relevant External Links for MRS2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRS2 Gene

Disorders for MRS2 Gene

(1) OMIM Diseases for MRS2 Gene (614730)

(1) University of Copenhagen DISEASES for MRS2 Gene

Relevant External Links for MRS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MRS2: view

No data available for UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for MRS2 Gene

Publications for MRS2 Gene

  1. The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter. (PMID: 11401429) Zsurka G. … Schweyen R.J. (Genomics 2001) 3 4 23
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for MRS2 Gene

Sources for MRS2 Gene

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