Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MRS2 Gene

protein-coding   GIFtS: 53
GCID: GC06P024403

MRS2 Magnesium Transporter

(Previous names: MRS2-like, magnesium homeostasis factor (S. cerevisiae),...)
(Previous symbol: MRS2L)
  See MRS2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
MRS2 Magnesium Transporter1 2     MRS2-Like, Magnesium Homeostasis Factor (S. Cerevisiae)1
MRS2L1 2 3     Magnesium Transporter MRS2 Homolog, Mitochondrial2
HPT2 3     MRS2-Like, Magnesium Homeostasis Factor2
MRS2-Like Protein2 3     HP5
MRS2 Magnesium Homeostasis Factor Homolog (S. Cerevisiae)1     PIGO5

External Ids:    HGNC: 137851   Entrez Gene: 573802   Ensembl: ENSG000001245327   OMIM: 6147305   UniProtKB: Q9HD233   

Export aliases for MRS2 gene to outside databases

Previous GC identifers: GC06P024512 GC06P024352


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for MRS2 Gene:
MRS2 (MRS2 magnesium transporter) is a protein-coding gene. Diseases associated with MRS2 include hyperphosphatasia with mental retardation syndrome 2, and hyperphosphatasia with mental retardation syndrome. GO annotations related to this gene include magnesium ion transmembrane transporter activity.

UniProtKB/Swiss-Prot: MRS2_HUMAN, Q9HD23
Function: Magnesium transporter that may mediate the influx of magnesium into the mitochondrial matrix

Gene Wiki entry for MRS2 (MRS2L) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRS2 gene promoter:
         Sox5   AML1a   HNF-1A   Evi-1   C/EBPalpha   FOXJ2 (long isoform)   HNF-1   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRS2 promoter sequence
   Search Chromatin IP Primers for MRS2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p22.3-p22.1   Ensembl cytogenetic band:  6p22.3   HGNC cytogenetic band: 6p22.3-p22.1

MRS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRS2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P024403:  view genomic region     (about GC identifiers)

Start:
24,403,153 bp from pter      End:
24,425,816 bp from pter
Size:
22,664 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: MRS2_HUMAN, Q9HD23 (See protein sequence)
Recommended Name: Magnesium transporter MRS2 homolog, mitochondrial precursor  
Size: 443 amino acids; 50318 Da
Miscellaneous: Has the ability to complement a deletion of MRS2 in S.cerevisiae and partly restore mitochondrial
magnesium concentrations
Sequence caution: Sequence=CAI17109.1; Type=Erroneous gene model prediction;
Secondary accessions: A8K4U3 B3KNN2 Q5T3Y1 Q6NTG4 Q96KF8 Q9BVP1
Alternative splicing: 3 isoforms:  Q9HD23-1   Q9HD23-2   Q9HD23-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MRS2: NX_Q9HD23

Explore proteomics data for MRS2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MRS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001273193.1  NP_001273194.1  NP_001273195.1  NP_065713.1  

    ENSEMBL proteins: 
     ENSP00000367604   ENSP00000367637   ENSP00000387441   ENSP00000441839   ENSP00000399585  
     ENSP00000274747   ENSP00000438118  

    MRS2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for MRS2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for MRS2
    GenScript Custom Purified and Recombinant Proteins Services for MRS2
    Novus Biologicals MRS2 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MRS2

     
    Search eBioscience for Proteins for MRS2 

    MRS2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for MRS2
    Novus Biologicals MRS2 Antibodies
    Abcam antibodies for MRS2
    Cloud-Clone Corp. Antibodies for MRS2
    ThermoFisher Antibodies for MRS2
    LSBio Antibodies in human, mouse, rat for MRS2

    MRS2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MRS2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MRS2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MRS2
    Cloud-Clone Corp. CLIAs for MRS2
    Search eBioscience for ELISAs for MRS2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR026573 MRS2/LPE10

    Graphical View of Domain Structure for InterPro Entry Q9HD23

    ProtoNet protein and cluster: Q9HD23

    1 Blocks protein domain: IPB002110 Ankyrin repeat signature

    UniProtKB/Swiss-Prot: MRS2_HUMAN, Q9HD23
    Similarity: Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family


    Find genes that share domains with MRS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MRS2_HUMAN, Q9HD23
    Function: Magnesium transporter that may mediate the influx of magnesium into the mitochondrial matrix

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015095magnesium ion transmembrane transporter activity IEA--
         
    Find genes that share ontologies with MRS2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRS2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MRS2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MRS2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MRS2

    miRNA
    Products:
        
    miRTarBase miRNAs that target MRS2:
    hsa-mir-744-5p (MIRT037639), hsa-mir-98-5p (MIRT027867), hsa-let-7a-5p (MIRT052486), hsa-mir-155-5p (MIRT021034), hsa-mir-20a-5p (MIRT050531)

    Block miRNA regulation of human, mouse, rat MRS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MRS2 (see all 25):
    hsa-miR-3938 hsa-let-7d hsa-miR-520d-5p hsa-miR-202 hsa-miR-134 hsa-let-7c hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidMRS2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MRS2
    Predesigned siRNA for gene silencing in human, mouse, rat MRS2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MRS2

    Clone
    Products:
         
    OriGene clones in human, mouse for MRS2 (see all 6)
    OriGene ORF clones in mouse, rat for MRS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MRS2 (NM_020662)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRS2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MRS2
    Browse ESI BIO Cell Lines and PureStem Progenitors for MRS2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRS2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    MRS2_HUMAN, Q9HD23: Mitochondrion inner membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with MRS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRS2
    Interactions:

        Search GeneGlobe Interaction Network for MRS2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MRS2 (ENSP000003676374) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC25A28ENSP000003595264STRING: ENSP00000359526
    SLC25A37ENSP000002900754STRING: ENSP00000290075
    PDHXENSP000002278684STRING: ENSP00000227868
    SLC25A33ENSP000003063284STRING: ENSP00000306328
    SLC25A36ENSP000003915214STRING: ENSP00000391521
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRS2

    1 HMDB Compound for MRS2    About this table
    CompoundSynonyms CAS #PubMed Ids
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 Novoseek inferred chemical compound relationship for MRS2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hygromycin 77.4 2 8676880 (1), 8877115 (1)



    Find genes that share compounds with MRS2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MRS2 gene (4 alternative transcripts): 
    NM_001286264.1  NM_001286265.1  NM_001286266.1  NM_020662.3  

    Unigene Cluster for MRS2:

    MRS2 magnesium homeostasis factor homolog (S. cerevisiae)
    Hs.658612  [show with all ESTs]
    Unigene Representative Sequence: NM_020662
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483634 ENST00000378353(uc003nea.3) ENST00000378386(uc003neb.3 uc011djl.2 uc011djm.2)
    ENST00000446191 ENST00000535061 ENST00000443868 ENST00000274747(uc011djn.2)
    ENST00000543597
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MRS2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MRS2 (see all 25):
    hsa-miR-3938 hsa-let-7d hsa-miR-520d-5p hsa-miR-202 hsa-miR-134 hsa-let-7c hsa-let-7g hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmidMRS2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MRS2
    Predesigned siRNA for gene silencing in human, mouse, rat MRS2
    Clone
    Products:
         
    OriGene clones in human, mouse for MRS2 (see all 6)
    OriGene ORF clones in mouse, rat for MRS2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MRS2 (NM_020662)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRS2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRS2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MRS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRS2
      QuantiTect SYBR Green Assays in human, mouse, rat MRS2
      QuantiFast Probe-based Assays in human, mouse, rat MRS2

    Additional mRNA sequence: 

    AF052167.1 AF288288.1 AF293076.1 AK054587.1 AK291058.1 AK297418.1 AK298849.1 AK299825.1 
    BC001028.2 BC018833.2 BC069009.1 

    11 DOTS entries:

    DT.95103805  DT.115600  DT.100764949  DT.97843846  DT.429174  DT.100791430  DT.95103804  DT.100716540 
    DT.100791420  DT.121374255  DT.95137956 

    Selected AceView cDNA sequences (see all 236):

    AA889912 AA827095 AW294016 BG031440 AW001052 BQ946908 CR618724 AW183177 
    AW025708 BX114390 AA781573 AA279625 AI283116 AA280002 AF293076 BC001028 
    AL699441 BF116203 CF995821 AI015707 BC069009 AA888080 BU165040 BC018833 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MRS2 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b · 12c · 12d · 12e ^ 13
    SP1:                                            -                                         -           -                       -     -         
    SP2:                                            -                                         -           -                                       
    SP3:                                                                                                                                          
    SP4:                          -     -     -     -     -     -                                         -     -                                 
    SP5:                                                                          -           -           -                                       


    ECgene alternative splicing isoforms for MRS2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MRS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAATAAAAG
    MRS2 Expression
    About this image

    MRS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.658612
        Custom PCR Arrays for MRS2
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MRS2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRS2
    QuantiTect SYBR Green Assays in human, mouse, rat MRS2
    QuantiFast Probe-based Assays in human, mouse, rat MRS2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MRS2 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrs21 , 5 MRS2 magnesium homeostasis factor homolog (S. cerevisiae)1, 5 81.87(n)1
    84.56(a)1
      13 (10.83 cM)5
    3808361  NM_001013389.21  NP_001013407.21 
     249924835 
    chicken
    (Gallus gallus)
    Aves MRS21 MRS2 magnesium homeostasis factor homolog (S. cerevisiae) 75.3(n)
    77.66(a)
      420820  XM_418911.4  XP_418911.2 
    lizard
    (Anolis carolinensis)
    Reptilia MRS26
    MRS2 magnesium transporter
    64(a)
    1 ↔ 1
    4(54091689-54110145)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mrs21 MRS2 magnesium transporter 72.61(n)
    74.47(a)
      100493829  XM_002937925.2  XP_002937971.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.228502 Transcribed sequence with moderate similarity to protein more 77.48(n)    AI658195.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MFM1(YPL060W)4
    MRS21
    Mitochondrial inner membrane magnesium transporter, more4
    MRS21
    43.26(n)1
    26.6(a)1
      16(434523-435764)4
    8545111  NP_014979.11  8560454 
     NP_015265.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MGT101 MGT10 42.14(n)
    28.3(a)
      832346  NM_122188.3  NP_568424.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g06844001 Os03g0684400 43.38(n)
    30.14(a)
      4333741  NM_001057454.1  NP_001050919.1 


    ENSEMBL Gene Tree for MRS2 (if available)
    TreeFam Gene Tree for MRS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MRS2 gene

    Find genes that share paralogs with MRS2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for MRS2
    PGOHUM00000239516 PGOHUM00000249795


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MRS2 (see all 727)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs12773431,2
    C,A--24401238(+) tttctT/Cttccc 1 -- us2k1 trp36Minor allele frequency- C:0.35NA WA EA 364
    rs1844624891,2
    --24401291(+) CTTTGC/TGCACT 1 -- us2k10--------
    rs1417003841,2
    --24401308(+) CTACTC/TCATCC 1 -- us2k10--------
    rs1504680581,2
    --24401330(+) ACCCTG/TCAGAA 1 -- us2k10--------
    rs1382069541,2
    --24401332(+) CCTGCA/GGAATA 1 -- us2k10--------
    rs1495968501,2
    --24401422(+) TTGTAC/TTACTA 1 -- us2k10--------
    rs1889048851,2
    --24401611(+) TGGTAC/GCTTAA 1 -- us2k10--------
    rs1820391541,2
    --24401624(+) TTGATA/GCTATC 1 -- us2k10--------
    rs132156651,2
    C,F--24401647(+) aaataC/TggAAT 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs93935531,2
    C,F,A,H--24401654(+) gAATAG/TAAATC 1 -- us2k121Minor allele frequency- T:0.32NS EA NA WA CSA 2520

    HapMap Linkage Disequilibrium report for MRS2 (24403153 - 24425816 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MRS2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671548CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRS2
    DNA2.0 Custom Variant and Variant Library Synthesis for MRS2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614730   
    OMIM disorders: 614749  
    2 diseases for MRS2:    
    About MalaCards
    hyperphosphatasia with mental retardation syndrome 2    hyperphosphatasia with mental retardation syndrome

    1 disease from the University of Copenhagen DISEASES database for MRS2:
    Cerebrovascular accident

    Find genes that share disorders with MRS2           About GenesLikeMe

    Genetic Association Database (GAD): MRS2
    Human Genome Epidemiology (HuGE) Navigator: MRS2 (1 document)

    Export disorders for MRS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MRS2 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with MRS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter. (PubMed id 11401429)1, 2, 9 Zsurka G.... Schweyen R.J. (Genomics 2001)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Human mitochondrial Mrs2 protein promotes multidrug resistance in gastric cancer cells by regulating p27, cyclin D1 expression and cytochrome C release. (PubMed id 19242098)1 Chen Y....Fan D. (amp 2009)
    10. Conditional knockdown of hMRS2 results in loss of mitochondrial Mg(2+) uptake and cell death. (PubMed id 18384665)1 Piskacek M....Schweyen R.J. (J. Cell. Mol. Med. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57380 HGNC: 13785 AceView: MRS2L Ensembl:ENSG00000124532 euGenes: HUgn57380
    ECgene: MRS2 H-InvDB: MRS2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MRS2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MRS2 gene:
    Search GeneIP for patents involving MRS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for MRS2  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MRS2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for MRS2  
     OriGene qSTAR qPCR primer pairs in human, mouse for MRS2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for MRS2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MRS2   OriGene Custom Protein Services for MRS2  

     
     
     Block miRNA regulation of human, mouse, rat MRS2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MRS2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRS2 Predesigned siRNA for gene silencing in human, mouse, rat MRS2
     QuantiFast Probe-based Assays in human, mouse, rat MRS2 QuantiTect SYBR Green Assays in human, mouse, rat MRS2
     Custom PCR Arrays for MRS2 Search Chromatin IP Primers for MRS2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRS2  Search GeneGlobe Interaction Network for MRS2
     Regulatory tfbs in MRS2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MRS2 GenScript cDNA clones with any tag delivered in your preferred vector for MRS2
     GenScript Custom Assay Services for MRS2 GenScript Custom overexpressing Cell Line Services for MRS2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MRS2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MRS2 antibodies
     MRS2 proteins
     Antibodies for MRS2
     See all of Abcam's Antibodies, Kits and Proteins for MRS2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MRS2
     Antibodies for MRS2
     ELISAs for MRS2
     CLIAs for MRS2



     Browse ESI BIO Cell Lines and PureStem Progenitors for MRS2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRS2
     SwitchGear 3'UTR luciferase reporter plasmids for MRS2
     SwitchGear Promoter luciferase reporter plasmids for MRS2
     ThermoFisher Antibodies for MRS2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRS2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRS2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MRS2
     LSBio Antibodies in human, mouse, rat for MRS2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for MRS2
      Search eBioscience for proteins for MRS2
      Search eBioscience for elisas for MRS2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MRS2 gene at Home site.
    Version: 3.12.210 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4