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Aliases for MRRF Gene

Aliases for MRRF Gene

  • Mitochondrial Ribosome Recycling Factor 2 3 5
  • Ribosome-Releasing Factor, Mitochondrial 3 4
  • RRF 3 4
  • Ribosome-Recycling Factor, Mitochondrial 3
  • MTRRF 3
  • MRFF 3

External Ids for MRRF Gene

Previous GeneCards Identifiers for MRRF Gene

  • GC09U990093
  • GC09P116679
  • GC09P118480
  • GC09P120409
  • GC09P120403
  • GC09P122106
  • GC09P124066
  • GC09P125026
  • GC09P094641

Summaries for MRRF Gene

Entrez Gene Summary for MRRF Gene

  • This gene encodes a ribosome recycling factor, which is a component of the mitochondrial translational machinery. The encoded protein, along with mitochondrial elongation factor 2, functions in ribosomal recycling at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Oct 2016]

GeneCards Summary for MRRF Gene

MRRF (Mitochondrial Ribosome Recycling Factor) is a Protein Coding gene. Diseases associated with MRRF include Robinow Syndrome, Autosomal Recessive and Uremic Neuropathy. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance.

UniProtKB/Swiss-Prot for MRRF Gene

  • Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity).

Additional gene information for MRRF Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRRF Gene

Genomics for MRRF Gene

Regulatory Elements for MRRF Gene

Enhancers for MRRF Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H121397 1.4 FANTOM5 Ensembl ENCODE 30 -865.5 -865480 3 PKNOX1 ATF1 RAD21 ZEB1 RFX5 ZNF366 ZNF143 FOS ATF7 ZNF202 GGTA1P PSMD5 CNTRL FBXW2 MRRF PSMD5-AS1 LOC102723324 STOM GSN-AS1 ENSG00000239593
GH09H121275 2 FANTOM5 Ensembl ENCODE dbSUPER 19.5 -981.8 -981798 15.3 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 MRRF PSMD5 CNTRL FBXW2 PSMD5-AS1 GSN GGTA1P C5 STOM LOC102723324
GH09H121319 1.6 Ensembl ENCODE dbSUPER 13.5 -941.1 -941102 8.5 HDGF FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 PSMD5 PSMD5-AS1 FBXW2 MRRF CNTRL GGTA1P C5 PIR41790 GSN-AS1
GH09H121366 1.7 FANTOM5 ENCODE dbSUPER 11.8 -894.2 -894164 7.5 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 GGTA1P PSMD5-AS1 PSMD5 MRRF CNTRL FBXW2 STOM GC09M121372
GH09H122826 1.3 ENCODE dbSUPER 13.5 +563.0 563049 3.2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 MRRF MORN5 STRBP PDCL GC09M122816
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRRF on UCSC Golden Path with GeneCards custom track

Promoters for MRRF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000241032 297 1801 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Locations for MRRF Gene

Genomic Locations for MRRF Gene
chr9:122,264,603-122,331,343
(GRCh38/hg38)
Size:
66,741 bases
Orientation:
Plus strand
chr9:125,026,882-125,085,743
(GRCh37/hg19)

Genomic View for MRRF Gene

Genes around MRRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRRF Gene

Proteins for MRRF Gene

  • Protein details for MRRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96E11-RRFM_HUMAN
    Recommended name:
    Ribosome-recycling factor, mitochondrial
    Protein Accession:
    Q96E11
    Secondary Accessions:
    • A8K6D8
    • A8K6Z4
    • B7Z4X5
    • B7Z6P7
    • Q5RKT1
    • Q5T7T0
    • Q5T7T1
    • Q5T7T2
    • Q5T7T3
    • Q5T7T4
    • Q5T7T5

    Protein attributes for MRRF Gene

    Size:
    262 amino acids
    Molecular mass:
    29277 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MRRF Gene

neXtProt entry for MRRF Gene

Post-translational modifications for MRRF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRRF Gene

Domains & Families for MRRF Gene

Gene Families for MRRF Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MRRF Gene

Suggested Antigen Peptide Sequences for MRRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96E11

UniProtKB/Swiss-Prot:

RRFM_HUMAN :
  • Belongs to the RRF family.
Family:
  • Belongs to the RRF family.
genes like me logo Genes that share domains with MRRF: view

Function for MRRF Gene

Molecular function for MRRF Gene

GENATLAS Biochemistry:
mitochondrial ribosome recycling factor,mitochondrial translational factor 1,widely expressed
UniProtKB/Swiss-Prot Function:
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity).

Phenotypes From GWAS Catalog for MRRF Gene

Gene Ontology (GO) - Molecular Function for MRRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043023 ribosomal large subunit binding IBA --
genes like me logo Genes that share ontologies with MRRF: view
genes like me logo Genes that share phenotypes with MRRF: view

Animal Model Products

CRISPR Products

miRNA for MRRF Gene

miRTarBase miRNAs that target MRRF

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRRF Gene

Localization for MRRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRRF Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRRF gene
Compartment Confidence
mitochondrion 5
cytoskeleton 2
cytosol 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MRRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with MRRF: view

Pathways & Interactions for MRRF Gene

genes like me logo Genes that share pathways with MRRF: view

Pathways by source for MRRF Gene

Gene Ontology (GO) - Biological Process for MRRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA --
GO:0032790 ribosome disassembly IDA 19716793
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRRF: view

No data available for SIGNOR curated interactions for MRRF Gene

Drugs & Compounds for MRRF Gene

No Compound Related Data Available

Transcripts for MRRF Gene

Unigene Clusters for MRRF Gene

Mitochondrial ribosome recycling factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRRF Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - - - - -
SP2: - - -
SP3: -
SP4: - - -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for MRRF Gene

GeneLoc Exon Structure for
MRRF
ECgene alternative splicing isoforms for
MRRF

Expression for MRRF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRRF Gene

Protein differential expression in normal tissues from HIPED for MRRF Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRRF Gene



Protein tissue co-expression partners for MRRF Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRRF Gene:

MRRF

SOURCE GeneReport for Unigene cluster for MRRF Gene:

Hs.368011

Evidence on tissue expression from TISSUES for MRRF Gene

  • Nervous system(4.6)
  • Muscle(4.4)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with MRRF: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRRF Gene

Orthologs for MRRF Gene

This gene was present in the common ancestor of animals.

Orthologs for MRRF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRRF 33 34
  • 99.24 (n)
cow
(Bos Taurus)
Mammalia MRRF 33 34 34
  • 90.2 (n)
dog
(Canis familiaris)
Mammalia MRRF 33 34
  • 90.2 (n)
mouse
(Mus musculus)
Mammalia Mrrf 33 16 34
  • 86.77 (n)
rat
(Rattus norvegicus)
Mammalia Mrrf 33
  • 86.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MRRF 34
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRRF 33 34
  • 67.82 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrrf 33
  • 64.01 (n)
zebrafish
(Danio rerio)
Actinopterygii mrrf 33 34
  • 65.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG4447 33 34
  • 49.56 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006804 33
  • 47.14 (n)
Species where no ortholog for MRRF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRRF Gene

ENSEMBL:
Gene Tree for MRRF (if available)
TreeFam:
Gene Tree for MRRF (if available)

Paralogs for MRRF Gene

(1) SIMAP similar genes for MRRF Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MRRF Gene

genes like me logo Genes that share paralogs with MRRF: view

No data available for Paralogs for MRRF Gene

Variants for MRRF Gene

Sequence variations from dbSNP and Humsavar for MRRF Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2297483 Uncertain significance 122,313,321(-) GTTCA(A/C/T)TGAGT intron-variant, nc-transcript-variant, reference, missense
rs1000013414 -- 122,319,242(+) GCCTC(C/G)TGGGT intron-variant
rs1000146984 -- 122,267,875(+) TCACT(A/G)TGATG intron-variant
rs1000159453 -- 122,295,441(+) AAGAT(C/G)AGTTT intron-variant
rs1000277864 -- 122,267,513(+) ATTGC(C/G)AAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRRF Gene

Variant ID Type Subtype PubMed ID
nsv831716 CNV gain 17160897
nsv6703 CNV insertion 18451855
nsv476505 CNV novel sequence insertion 20440878

Variation tolerance for MRRF Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRRF Gene

Human Gene Mutation Database (HGMD)
MRRF
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRRF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRRF Gene

Disorders for MRRF Gene

MalaCards: The human disease database

(8) MalaCards diseases for MRRF Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
robinow syndrome, autosomal recessive
  • fetal face syndrome
uremic neuropathy
epidemic typhus
  • sylvatic typhus
lipomatosis, multiple symmetric
  • multiple symmetric lipomatosis
robinow syndrome
  • acral dysostosis with facial and genital abnormalities
- elite association - COSMIC cancer census association via MalaCards
Search MRRF in MalaCards View complete list of genes associated with diseases

Relevant External Links for MRRF

Genetic Association Database (GAD)
MRRF
Human Genome Epidemiology (HuGE) Navigator
MRRF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRRF
genes like me logo Genes that share disorders with MRRF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRRF Gene

Publications for MRRF Gene

  1. Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor. (PMID: 9838146) Zhang Y … Spremulli LL (Biochimica et biophysica acta 1998) 2 3 4 22 60
  2. Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1-->q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32-->q34.1 with radiation hybrid mapping. (PMID: 10773675) Hansen LL … Justesen J (Cytogenetics and cell genetics 2000) 2 3 22 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  5. The human mitochondrial ribosome recycling factor is essential for cell viability. (PMID: 18782833) Rorbach J … Chrzanowska-Lightowlers ZM (Nucleic acids research 2008) 3 22 60

Products for MRRF Gene

Sources for MRRF Gene

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