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MRRF Gene

protein-coding   GIFtS: 58
GCID: GC09P125026

Mitochondrial Ribosome Recycling Factor

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Ribosome Recycling Factor1 2
RRF2 3 5
Ribosome-Releasing Factor, Mitochondrial2 3
MRFF2 5
MTRRF2
Ribosome-Recycling Factor, Mitochondrial2

External Ids:    HGNC: 72341   Entrez Gene: 923992   Ensembl: ENSG000001481877   OMIM: 6046025   UniProtKB: Q96E113   

Export aliases for MRRF gene to outside databases

Previous GC identifers: GC09U990093 GC09P116679 GC09P118480 GC09P120409 GC09P120403 GC09P122106 GC09P124066 GC09P094641


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for MRRF Gene:
MRRF (mitochondrial ribosome recycling factor) is a protein-coding gene. Diseases associated with MRRF include end stage renal failure, and lyme disease.

UniProtKB/Swiss-Prot: RRFM_HUMAN, Q96E11
Function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.
May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008470.20  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRRF gene promoter:
         Sox5   FOXF2   POU3F1   FOXD3   E47   POU2F1   POU2F1b   POU2F1a   Hand1   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRRF promoter sequence
   Search Chromatin IP Primers for MRRF

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRRF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.2   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q32-q34.1

MRRF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRRF gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P125026:  view genomic region     (about GC identifiers)

Start:
125,026,882 bp from pter      End:
125,085,743 bp from pter
Size:
58,862 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RRFM_HUMAN, Q96E11 (See protein sequence)
Recommended Name: Ribosome-recycling factor, mitochondrial precursor  
Size: 262 amino acids; 29277 Da
Secondary accessions: A8K6D8 A8K6Z4 B7Z4X5 B7Z6P7 Q5RKT1 Q5T7T0 Q5T7T1 Q5T7T2 Q5T7T3 Q5T7T4
Q5T7T5
Alternative splicing: 8 isoforms:  Q96E11-1   Q96E11-2   Q96E11-3   Q96E11-4   Q96E11-5   Q96E11-6   Q96E11-7   Q96E11-8   
(Derived from EST data. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MRRF: NX_Q96E11

Explore proteomics data for MRRF at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MRRF Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001166983.1  NP_620132.1  NP_954646.1  

    ENSEMBL proteins: 
     ENSP00000343867   ENSP00000395072   ENSP00000362828   ENSP00000362834   ENSP00000434807  
     ENSP00000433288   ENSP00000436360   ENSP00000297908   ENSP00000377850   ENSP00000362835  
     ENSP00000445588  

    MRRF Human Recombinant Protein Products:

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    Novus Biologicals MRRF Proteins
    Novus Biologicals MRRF Lysates
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    ProSpec Recombinant Protein for MRRF
    Cloud-Clone Corp. Proteins for MRRF

    MRRF Antibody Products:

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    Abcam antibodies for MRRF
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    ThermoFisher Antibodies for MRRF
    LSBio Antibodies in human, mouse, rat for MRRF

    MRRF Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for MRRF
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MRRF
    Cloud-Clone Corp. CLIAs for MRRF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR002661 Ribosome_recyc_fac
     IPR024946 Arg_repress_C-like
     IPR023584 Ribosome_recyc_fac_dom

    Graphical View of Domain Structure for InterPro Entry Q96E11

    ProtoNet protein and cluster: Q96E11

    1 Blocks protein domain: IPB002661 Ribosome recycling factor

    UniProtKB/Swiss-Prot: RRFM_HUMAN, Q96E11
    Similarity: Belongs to the RRF family


    MRRF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RRFM_HUMAN, Q96E11
    Function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.
    May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By
    similarity)

         Genatlas biochemistry entry for MRRF:
    mitochondrial ribosome recycling factor,mitochondrial translational factor 1,widely expressed

    Phenotypes:
         1 GenomeRNAi human phenotype for MRRF:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRRF
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MRRF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MRRF
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MRRF

    miRNA
    Products:
        
    miRTarBase miRNAs that target MRRF:
    hsa-mir-16-5p (MIRT031902)

    Block miRNA regulation of human, mouse, rat MRRF using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MRRF:
    hsa-miR-24-2* hsa-miR-24-1* hsa-miR-2278 hsa-miR-323b-5p
    SwitchGear 3'UTR luciferase reporter plasmidMRRF 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MRRF
    Predesigned siRNA for gene silencing in human, mouse, rat MRRF

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MRRF

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    GenScript: all cDNA clones in your preferred vector (see all 3): MRRF (NM_138777)
    Sino Biological Human cDNA Clone for MRRF
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRRF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRRF

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for MRRF 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRRF


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RRFM_HUMAN, Q96E11: Mitochondrion (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    MRRF for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRRF
    Interactions:

        Search GeneGlobe Interaction Network for MRRF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MRRF (Q96E112, 3 ENSP000002979084) via UniProtKB, MINT, STRING, and/or I2D (see all 328)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ECH1Q130112, 3MINT-8079030 I2D: score=4 
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    MRPL19P494062, ENSP000003774864MINT-8079030 STRING: ENSP00000377486
    MRPS11P829122, ENSP000003173764MINT-8079030 STRING: ENSP00000317376
    MRPS9P829332, ENSP000002584554MINT-8079030 STRING: ENSP00000258455
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation IEA--
    GO:0032790ribosome disassembly IDA19716793

    MRRF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRRF (RRFM)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MRRF gene (4 alternative transcripts): 
    NM_199176.1  NM_001173512.1  NM_138777.3  NM_199177.2  

    Unigene Cluster for MRRF:

    Mitochondrial ribosome recycling factor
    Hs.368011  [show with all ESTs]
    Unigene Representative Sequence: NM_138777
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344641(uc010mwa.3 uc004bme.3 uc022bmy.1) ENST00000441707
    ENST00000373723 ENST00000373729 ENST00000373727 ENST00000373728(uc011lyq.2)
    ENST00000470366(uc010mvz.2) ENST00000373724 ENST00000467864 ENST00000489572
    ENST00000297908(uc011lyr.2) ENST00000394315 ENST00000373730 ENST00000546115

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MRRF using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate MRRF:
    hsa-miR-24-2* hsa-miR-24-1* hsa-miR-2278 hsa-miR-323b-5p
    SwitchGear 3'UTR luciferase reporter plasmidMRRF 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MRRF
    Predesigned siRNA for gene silencing in human, mouse, rat MRRF
    Clone
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    OriGene clones in human, mouse for MRRF (see all 17)
    OriGene ORF clones in mouse, rat for MRRF
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): MRRF (NM_138777)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRRF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRRF
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MRRF
    OriGene qSTAR qPCR primer pairs in human, mouse for MRRF
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRRF
      QuantiTect SYBR Green Assays in human, mouse, rat MRRF
      QuantiFast Probe-based Assays in human, mouse, rat MRRF

    Additional mRNA sequence: 

    AK291603.1 AK291809.1 AK292790.1 AK298046.1 AK300718.1 AK310974.1 AK316266.1 BC002814.2 
    BC013049.1 BC053604.1 

    18 DOTS entries:

    DT.92436015  DT.95179518  DT.99934137  DT.100807554  DT.100807551  DT.116034  DT.100807553  DT.92436021 
    DT.100036188  DT.40119846  DT.95319821  DT.121172506  DT.121172584  DT.121172617  DT.121172568  DT.40287695 
    DT.91830351  DT.92436016 

    Selected AceView cDNA sequences (see all 230):

    AA309964 AA115320 AA768644 AA284784 CB528654 CB242867 BI756457 AA829871 
    BQ019425 CA405882 BF149408 AI223228 BM807017 AI126601 BU733766 CB991137 
    AA890538 BM835493 AI869322 NM_199176 BF982227 AW673671 AA482074 CB158413 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MRRF (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                    -     -     -     -                       -           -     -                     
    SP2:                                                              -           -     -                     
    SP3:                    -                                                                                 
    SP4:                    -     -     -                                                                     
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for MRRF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRRF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTTTTCTC
    MRRF Expression
    About this image


    MRRF expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    MRRF Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRRF Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.368011
        Custom PCR Arrays for MRRF
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    QuantiFast Probe-based Assays in human, mouse, rat MRRF
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRRF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MRRF gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrrf1 , 5 mitochondrial ribosome recycling factor1, 5 86.77(n)1
    85.11(a)1
      2 (24.19 cM)5
    678711  NM_026422.21  NP_080698.11 
     361363895 
    chicken
    (Gallus gallus)
    Aves MRRF1 mitochondrial ribosome recycling factor 67.82(n)
    61.78(a)
      417110  XM_415395.3  XP_415395.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BI442091.12   -- 73.86(n)    BI442091.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mrrf1 mitochondrial ribosome recycling factor 65.87(n)
    67.46(a)
      431721  NM_001002174.1  NP_001002174.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG44471 CG4447 49.56(n)
    38.22(a)
      39067  NM_140045.3  NP_648302.2 


    ENSEMBL Gene Tree for MRRF (if available)
    TreeFam Gene Tree for MRRF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MRRF gene
    1 SIMAP similar gene for MRRF using alignment to 1 protein entry:     RRFM_HUMAN:
    MRRFP1

    MRRF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MRRF (see all 1020)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1807544111,2
    --125029148(+) GGGGTC/TGAGAC 2 -- int10--------
    rs1467002791,2
    C--125029222(+) CGCACA/GCCTGT 2 -- int10--------
    rs1847704941,2
    --125029285(+) CGGAGA/GTTGCA 2 -- int10--------
    rs1896829991,2
    --125029343(+) GACTCA/CGTCTC 2 -- int10--------
    rs70245531,2
    C,F,A--125029399(+) acgccA/G/Tgtaat 2 -- int15NA WA CSA 10
    rs1137990521,2
    C,F--125029445(+) CTGAGG/ATAAGG 2 -- int11Minor allele frequency- A:0.50WA 2
    rs70242681,2
    C,F,A--125029448(+) aggtaG/Aggagt 2 -- int11Minor allele frequency- A:0.50WA 2
    rs1858512971,2
    --125029547(+) CCCACC/TTACTC 2 -- int10--------
    rs1909951801,2
    C--125029574(+) AGAATA/CCCCTG 2 -- int10--------
    rs1818296781,2
    --125029601(+) GTTGCA/GGTGAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for MRRF (125026882 - 125085743 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MRRF:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv6703CNV Insertion18451855
    nsv831716CNV Gain17160897

    Human Gene Mutation Database (HGMD): MRRF
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRRF
    DNA2.0 Custom Variant and Variant Library Synthesis for MRRF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604602    OMIM disorders: --

    7 diseases for MRRF:    
    About MalaCards
    end stage renal failure    lyme disease    lactic acidosis    peritonitis
    pneumonia    tuberculosis    malaria


    MRRF for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRRF
    Human Genome Epidemiology (HuGE) Navigator: MRRF (2 documents)

    Export disorders for MRRF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRRF gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with MRRF)
        Utopia: connect your pdf to the dynamic
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    1. Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor. (PubMed id 9838146)1, 2, 3, 9 Zhang Y. and Spremulli L.L. (Biochim. Biophys. Acta 1998)
    2. Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1--&gt;q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32--&gt;q34.1 with radiation hybrid mapping. (PubMed id 10773675)1, 3, 9 Hansen L.L....Justesen J. (Cytogenet. Cell Genet. 2000)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The human mitochondrial ribosome recycling factor is essential for cell viability. (PubMed id 18782833)1, 9 Rorbach J....Chrzanowska-Lightowlers Z.M. (Nucleic Acids Res. 2008)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 92399 HGNC: 7234 AceView: MRRF Ensembl:ENSG00000148187 euGenes: HUgn92399
    ECgene: MRRF H-InvDB: MRRF

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRRF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MRRF gene:
    Search GeneIP for patents involving MRRF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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