MRRF Gene
protein-coding GIFtS: 51
GCID: GC09P125026
|
|
mitochondrial ribosome recycling factor
| |
Aliases
for MRRF gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosome Recycling Factor1 2 | | RRF1 2 3 5 | | Ribosome-Releasing Factor, Mitochondrial2 3 | | MRFF2 5 | | MTRRF2 | | Ribosome-Recycling Factor, Mitochondrial2 |
Export aliases for MRRF gene to outside databasesPrevious GC identifers: GC09U990093 GC09P116679 GC09P118480 GC09P120409 GC09P120403 GC09P122106 GC09P124066 GC09P094641 |
Summaries
for MRRF gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: RRFM_HUMAN, Q96E11Function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. Mayincrease the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
|
Genomic Views
for MRRF gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRRF gene promoter:
Sox5 FOXF2 POU3F1 FOXD3 E47 POU2F1 POU2F1b POU2F1a Hand1 POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRRF
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRRF |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q33.2 Ensembl cytogenetic band: 9q33.2 HGNC cytogenetic band: 9q32-q34.1MRRF Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P125026: view genomic region
(about GC identifiers)
Start:
|
125,026,882 bp from pter |
End:
|
125,085,743 bp from pter |
Size:
|
58,862 bases |
Orientation:
|
plus strand |
|
Proteins
for MRRF gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RRFM_HUMAN, Q96E11 (See
protein sequence)Recommended Name: Ribosome-recycling factor, mitochondrial precursor Size: 262 amino acids; 29277 Da
Subcellular location: Mitochondrion (By similarity)
Secondary accessions: A8K6D8 A8K6Z4 B7Z4X5 B7Z6P7 Q5RKT1 Q5T7T0 Q5T7T1 Q5T7T2 Q5T7T3 Q5T7T4 Q5T7T5Alternative splicing: 8 isoforms: Q96E11-1 Q96E11-2 Q96E11-3 Q96E11-4 Q96E11-5 Q96E11-6 Q96E11-7 Q96E11-8 (Derived from EST data. No experimental confirmation available)Explore the universe of human proteins at neXtProt for MRRF: NX_Q96E11
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96E11
MRRF Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001166983.1 NP_620132.1 NP_954646.1
ENSEMBL proteins: ENSP00000343867 ENSP00000395072 ENSP00000362834 ENSP00000362832 ENSP00000362833 ENSP00000434807 ENSP00000362829 ENSP00000433288 ENSP00000436360 ENSP00000297908 ENSP00000362828 ENSP00000377850 ENSP00000362835 ENSP00000445588
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
MRRF for ontologies About GeneDecksing
MRRF Antibody Products:
Assay Products for MRRF: |
Protein
Domains /
Families
for MRRF gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRRF for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96E11ProtoNet protein and cluster: Q96E11 1 Blocks protein family: IPB002661 Ribosome recycling factor
UniProtKB/Swiss-Prot: RRFM_HUMAN, Q96E11Similarity: Belongs to the RRF family |
Function
for MRRF gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: RRFM_HUMAN, Q96E11Function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. Mayincrease the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Genatlas biochemistry entry for MRRF:mitochondrial ribosome recycling factor,mitochondrial translational factor 1,widely expressed
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRRF (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRRF (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): MRRF (NM_138777) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRRF | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRRF |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRRF |
1 GenomeRNAi human phenotype for MRRF:
|
Pathways & Interactions
for MRRF gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRRF
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/254 Interacting proteins for MRRF (Q96E112, 3 ENSP000002979084) via UniProtKB, MINT, STRING, and/or I2D (see all 254)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
MRRF for ontologies About GeneDecksing
|
Drugs & Compounds
for MRRF gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRRF
Search CenterWatch for drugs/clinical trials and news about MRRF / RRFM
|
Transcripts
for MRRF gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRRF gene (4 alternative transcripts): NM_199176.1 NM_001173512.1 NM_138777.3 NM_199177.2 Unigene Cluster for MRRF: Mitochondrial ribosome recycling factor Hs.368011 [show with all ESTs]Unigene Representative Sequence: NM_13877714 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000344641(uc010mwa.3 uc004bme.3 uc022bmy.1) ENST00000441707
ENST00000373729 ENST00000373727 ENST00000373728(uc011lyq.2) ENST00000470366(uc010mvz.2)
ENST00000373724 ENST00000467864 ENST00000489572 ENST00000297908(uc011lyr.2)
ENST00000373723 ENST00000394315 ENST00000373730 ENST00000546115
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRRF (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRRF (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): MRRF (NM_138777) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRRF | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRRF |
Additional cDNA sequence: AK291603.1 AK291809.1 AK292790.1 AK298046.1 AK300718.1 AK310974.1 AK316266.1 BC002814.2 BC013049.1 BC053604.1 18 DOTS entries: DT.92436015 DT.95179518 DT.99934137 DT.100807554 DT.100807551 DT.116034 DT.100807553 DT.92436021 DT.100036188 DT.40119846 DT.95319821 DT.121172506 DT.121172584 DT.121172617 DT.121172568 DT.40287695 DT.91830351 DT.92436016 24/230 AceView cDNA sequences (see all 230): AA890538 CA429471 BU733766 AA829871 CA405882 BM807017 NM_138777 BF982227 BQ019425 AJ712488 AA284713 AI126601 BU507072 AI869322 BM835493 AW264188 AA309964 CB528654 W74755 BC053604 AI640522 AA284784 AA115320 CD244098
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MRRF (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | | | | | | | - | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MRRF
|
Expression
for MRRF gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRRF expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGTTTTCTC
About this image
See MRRF Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRRF
SOURCE GeneReport for Unigene cluster: Hs.368011
SABiosciences Custom PCR Arrays for MRRF
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRRF
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRRF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRRF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRRF | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRRF |
Orthologs
for MRRF gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MRRF gene from 8/28 species (see all 28) About this table
ENSEMBL Gene Tree for MRRF (if available)
TreeFam Gene Tree for MRRF (if available) |
Paralogs
for MRRF gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRRF gene
- MRRFP12
1 SIMAP similar gene for MRRF using alignment to 1 protein entry: RRFM_HUMAN:MRRFP1
MRRF for paralogs About GeneDecksing
|
Genomic Variants
for MRRF gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRRF (125026882 - 125085743 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MRRF: --
Human Gene Mutation Database (HGMD): MRRF
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRRF |
|
Disorders
/ Diseases
for MRRF gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRRF for disorders About GeneDecksing
OMIM gene information: 604602
OMIM disorders: --
7  diseases for MRRF: About MalaCardsend stage renal failure lactic acidosis lyme disease peritonitis
pneumonia tuberculosis mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: MRRF (2 documents)
Export disorders for MRRF gene to outside databases
|
Publications
for MRRF gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRRF gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with MRRF) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor. (PubMed id 9838146)1, 2, 3, 9 Zhang Y. and Spremulli L.L. (1998)
- Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1-->q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32-->q34.1 with radiation hybrid mapping. (PubMed id 10773675)1, 3, 9 Hansen L.L....Justesen J. (2000)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The human mitochondrial ribosome recycling factor is essential for cell viability. (PubMed id 18782833)1, 9 Rorbach J....Chrzanowska-Lightowlers Z.M. (2008)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
|
External Searches for MRRF gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRRF gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRRF gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRRF gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRRF | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRRF gene:
Search GeneIP for patents involving MRRF
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRRF gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRRF | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRRF | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRRF | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRRF | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRRF | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRRF |
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 | | | MRRF Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRRF |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRRF |
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