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Aliases for MRRF Gene

Aliases for MRRF Gene

  • Mitochondrial Ribosome Recycling Factor 2 3
  • RRF 3 4 6
  • Ribosome-Releasing Factor, Mitochondrial 3 4
  • MRFF 3 6
  • Ribosome-Recycling Factor, Mitochondrial 3
  • MTRRF 3

External Ids for MRRF Gene

Previous GeneCards Identifiers for MRRF Gene

  • GC09U990093
  • GC09P116679
  • GC09P118480
  • GC09P120409
  • GC09P120403
  • GC09P122106
  • GC09P124066
  • GC09P125026
  • GC09P094641

Summaries for MRRF Gene

GeneCards Summary for MRRF Gene

MRRF (Mitochondrial Ribosome Recycling Factor) is a Protein Coding gene.

UniProtKB/Swiss-Prot for MRRF Gene

  • Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRRF Gene

Genomics for MRRF Gene

Regulatory Elements for MRRF Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRRF Gene

Start:
122,264,603 bp from pter
End:
122,323,464 bp from pter
Size:
58,862 bases
Orientation:
Plus strand

Genomic View for MRRF Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRRF Gene

Proteins for MRRF Gene

  • Protein details for MRRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96E11-RRFM_HUMAN
    Recommended name:
    Ribosome-recycling factor, mitochondrial
    Protein Accession:
    Q96E11
    Secondary Accessions:
    • A8K6D8
    • A8K6Z4
    • B7Z4X5
    • B7Z6P7
    • Q5RKT1
    • Q5T7T0
    • Q5T7T1
    • Q5T7T2
    • Q5T7T3
    • Q5T7T4
    • Q5T7T5

    Protein attributes for MRRF Gene

    Size:
    262 amino acids
    Molecular mass:
    29277 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MRRF Gene

neXtProt entry for MRRF Gene

Proteomics data for MRRF Gene at MOPED

Post-translational modifications for MRRF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRRF Gene

Domains for MRRF Gene

Protein Domains for MRRF Gene

Suggested Antigen Peptide Sequences for MRRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96E11

UniProtKB/Swiss-Prot:

RRFM_HUMAN :
  • Q96E11
Family:
  • Belongs to the RRF family.
genes like me logo Genes that share domains with MRRF: view

No data available for Gene Families for MRRF Gene

Function for MRRF Gene

Molecular function for MRRF Gene

GENATLAS Biochemistry: mitochondrial ribosome recycling factor,mitochondrial translational factor 1,widely expressed
UniProtKB/Swiss-Prot Function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity).

Phenotypes for MRRF Gene

GenomeRNAi human phenotypes for MRRF:
genes like me logo Genes that share phenotypes with MRRF: view

Animal Model Products

CRISPR Products

miRNA for MRRF Gene

miRTarBase miRNAs that target MRRF

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRRF Gene

Localization for MRRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRRF Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRRF Gene COMPARTMENTS Subcellular localization image for MRRF gene
Compartment Confidence
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for MRRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with MRRF: view

Pathways for MRRF Gene

SuperPathways for MRRF Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0032790 ribosome disassembly IDA 19716793
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRRF: view

No data available for Pathways by source for MRRF Gene

Transcripts for MRRF Gene

Unigene Clusters for MRRF Gene

Mitochondrial ribosome recycling factor:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRRF

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRRF Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - - - - -
SP2: - - -
SP3: -
SP4: - - -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for MRRF Gene

GeneLoc Exon Structure for
MRRF
ECgene alternative splicing isoforms for
MRRF

Expression for MRRF Gene

mRNA expression in normal human tissues for MRRF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRRF Gene

SOURCE GeneReport for Unigene cluster for MRRF Gene Hs.368011

genes like me logo Genes that share expressions with MRRF: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRRF Gene

Orthologs for MRRF Gene

This gene was present in the common ancestor of animals.

Orthologs for MRRF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRRF 35
  • 99.24 (n)
  • 98.85 (a)
MRRF 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRRF 35
  • 90.2 (n)
  • 88.55 (a)
MRRF 36
  • 84 (a)
OneToMany
MRRF 36
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MRRF 35
  • 90.2 (n)
  • 87.79 (a)
MRRF 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrrf 35
  • 86.77 (n)
  • 85.11 (a)
Mrrf 16
Mrrf 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRRF 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrrf 35
  • 86.51 (n)
  • 85.11 (a)
chicken
(Gallus gallus)
Aves MRRF 35
  • 67.82 (n)
  • 61.78 (a)
MRRF 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrrf 35
  • 64.01 (n)
  • 60.16 (a)
zebrafish
(Danio rerio)
Actinopterygii mrrf 35
  • 65.87 (n)
  • 67.46 (a)
mrrf 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006804 35
  • 47.14 (n)
  • 36.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4447 35
  • 49.56 (n)
  • 38.22 (a)
CG4447 36
  • 35 (a)
OneToOne
Species with no ortholog for MRRF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRRF Gene

ENSEMBL:
Gene Tree for MRRF (if available)
TreeFam:
Gene Tree for MRRF (if available)

Paralogs for MRRF Gene

Selected SIMAP similar genes for MRRF Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MRRF: view

No data available for Paralogs for MRRF Gene

Variants for MRRF Gene

Sequence variations from dbSNP and Humsavar for MRRF Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs954451 -- 122,288,817(+) GAATA(A/C)CAAAG intron-variant
rs1888219 -- 122,285,837(+) CACCA(A/G)TTTGT intron-variant, nc-transcript-variant
rs2026152 -- 122,301,541(-) agctt(C/T)tccca intron-variant
rs2183417 -- 122,284,748(+) TCTTG(C/T)CACAT intron-variant
rs2297483 - 122,313,321(-) GTTCA(C/T)TGAGT reference, missense, intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MRRF Gene

Variant ID Type Subtype PubMed ID
nsv831716 CNV Gain 17160897
nsv6703 CNV Insertion 18451855

Relevant External Links for MRRF Gene

HapMap Linkage Disequilibrium report
MRRF
Human Gene Mutation Database (HGMD)
MRRF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRRF Gene

Disorders for MRRF Gene

Relevant External Links for MRRF

Genetic Association Database (GAD)
MRRF
Human Genome Epidemiology (HuGE) Navigator
MRRF
genes like me logo Genes that share disorders with MRRF: view

No data available for UniProtKB/Swiss-Prot for MRRF Gene

Publications for MRRF Gene

  1. Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor. (PMID: 9838146) Zhang Y. … Spremulli L.L. (Biochim. Biophys. Acta 1998) 2 3 4 23
  2. Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1-->q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32-->q34.1 with radiation hybrid mapping. (PMID: 10773675) Hansen L.L. … Justesen J. (Cytogenet. Cell Genet. 2000) 2 3 23
  3. The human mitochondrial ribosome recycling factor is essential for cell viability. (PMID: 18782833) Rorbach J. … Chrzanowska-Lightowlers Z.M. (Nucleic Acids Res. 2008) 3 23
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MRRF Gene

Sources for MRRF Gene

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