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Aliases for MRRF Gene

Aliases for MRRF Gene

  • Mitochondrial Ribosome Recycling Factor 2 3 5
  • Ribosome-Releasing Factor, Mitochondrial 3 4
  • RRF 3 4
  • MTRRF 3
  • MRFF 3

External Ids for MRRF Gene

Previous GeneCards Identifiers for MRRF Gene

  • GC09U990093
  • GC09P116679
  • GC09P118480
  • GC09P120409
  • GC09P120403
  • GC09P122106
  • GC09P124066
  • GC09P125026
  • GC09P094641

Summaries for MRRF Gene

GeneCards Summary for MRRF Gene

MRRF (Mitochondrial Ribosome Recycling Factor) is a Protein Coding gene. Diseases associated with MRRF include Epidemic Typhus and Uremic Neuropathy. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance.

UniProtKB/Swiss-Prot for MRRF Gene

  • Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRRF Gene

Genomics for MRRF Gene

Regulatory Elements for MRRF Gene

Enhancers for MRRF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRRF on UCSC Golden Path with GeneCards custom track

Promoters for MRRF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRRF on UCSC Golden Path with GeneCards custom track

Genomic Location for MRRF Gene

Chromosome:
9
Start:
122,264,603 bp from pter
End:
122,331,343 bp from pter
Size:
66,741 bases
Orientation:
Plus strand

Genomic View for MRRF Gene

Genes around MRRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRRF Gene

Proteins for MRRF Gene

  • Protein details for MRRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96E11-RRFM_HUMAN
    Recommended name:
    Ribosome-recycling factor, mitochondrial
    Protein Accession:
    Q96E11
    Secondary Accessions:
    • A8K6D8
    • A8K6Z4
    • B7Z4X5
    • B7Z6P7
    • Q5RKT1
    • Q5T7T0
    • Q5T7T1
    • Q5T7T2
    • Q5T7T3
    • Q5T7T4
    • Q5T7T5

    Protein attributes for MRRF Gene

    Size:
    262 amino acids
    Molecular mass:
    29277 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MRRF Gene

neXtProt entry for MRRF Gene

Proteomics data for MRRF Gene at MOPED

Post-translational modifications for MRRF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRRF Gene

Domains & Families for MRRF Gene

Protein Domains for MRRF Gene

Suggested Antigen Peptide Sequences for MRRF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96E11

UniProtKB/Swiss-Prot:

RRFM_HUMAN :
  • Belongs to the RRF family.
Family:
  • Belongs to the RRF family.
genes like me logo Genes that share domains with MRRF: view

No data available for Gene Families for MRRF Gene

Function for MRRF Gene

Molecular function for MRRF Gene

GENATLAS Biochemistry:
mitochondrial ribosome recycling factor,mitochondrial translational factor 1,widely expressed
UniProtKB/Swiss-Prot Function:
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity).
genes like me logo Genes that share phenotypes with MRRF: view

Animal Model Products

miRNA for MRRF Gene

miRTarBase miRNAs that target MRRF

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRRF Gene

Localization for MRRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRRF Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRRF Gene COMPARTMENTS Subcellular localization image for MRRF gene
Compartment Confidence
mitochondrion 5
cytoskeleton 2
cytosol 2
chloroplast 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for MRRF Gene

Pathways & Interactions for MRRF Gene

genes like me logo Genes that share pathways with MRRF: view

Pathways by source for MRRF Gene

Gene Ontology (GO) - Biological Process for MRRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0032790 ribosome disassembly IDA 19716793
genes like me logo Genes that share ontologies with MRRF: view

No data available for SIGNOR curated interactions for MRRF Gene

Drugs & Compounds for MRRF Gene

No Compound Related Data Available

Transcripts for MRRF Gene

Unigene Clusters for MRRF Gene

Mitochondrial ribosome recycling factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRRF Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - - - - -
SP2: - - -
SP3: -
SP4: - - -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for MRRF Gene

GeneLoc Exon Structure for
MRRF
ECgene alternative splicing isoforms for
MRRF

Expression for MRRF Gene

mRNA expression in normal human tissues for MRRF Gene

Protein differential expression in normal tissues from HIPED for MRRF Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRRF Gene



SOURCE GeneReport for Unigene cluster for MRRF Gene Hs.368011

genes like me logo Genes that share expression patterns with MRRF: view

Protein tissue co-expression partners for MRRF Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRRF Gene

Orthologs for MRRF Gene

This gene was present in the common ancestor of animals.

Orthologs for MRRF Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRRF 35
  • 90.2 (n)
  • 88.55 (a)
MRRF 36
  • 84 (a)
OneToMany
MRRF 36
  • 93 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MRRF 35
  • 90.2 (n)
  • 87.79 (a)
MRRF 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrrf 35
  • 86.77 (n)
  • 85.11 (a)
Mrrf 16
Mrrf 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRRF 35
  • 99.24 (n)
  • 98.85 (a)
MRRF 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrrf 35
  • 86.51 (n)
  • 85.11 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia MRRF 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRRF 35
  • 67.82 (n)
  • 61.78 (a)
MRRF 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrrf 35
  • 64.01 (n)
  • 60.16 (a)
zebrafish
(Danio rerio)
Actinopterygii mrrf 35
  • 65.87 (n)
  • 67.46 (a)
mrrf 36
  • 57 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006804 35
  • 47.14 (n)
  • 36.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4447 35
  • 49.56 (n)
  • 38.22 (a)
CG4447 36
  • 35 (a)
OneToOne
Species with no ortholog for MRRF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRRF Gene

ENSEMBL:
Gene Tree for MRRF (if available)
TreeFam:
Gene Tree for MRRF (if available)

Paralogs for MRRF Gene

(1) SIMAP similar genes for MRRF Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MRRF: view

No data available for Paralogs for MRRF Gene

Variants for MRRF Gene

Sequence variations from dbSNP and Humsavar for MRRF Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2297483 - 122,313,321(-) GTTCA(C/T)TGAGT intron-variant, nc-transcript-variant, reference, missense
rs954451 -- 122,288,817(+) GAATA(A/C)CAAAG intron-variant
rs7847957 -- 122,278,925(+) gaagt(A/G)cagtg intron-variant
rs7855241 -- 122,280,145(+) aggta(A/G)ggaac intron-variant
rs112984448 -- 122,307,228(+) TGTAG(A/C/G/T)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRRF Gene

Variant ID Type Subtype PubMed ID
nsv831716 CNV Gain 17160897
nsv6703 CNV Insertion 18451855

Variation tolerance for MRRF Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRRF Gene

Human Gene Mutation Database (HGMD)
MRRF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRRF Gene

Disorders for MRRF Gene

MalaCards: The human disease database

(7) MalaCards diseases for MRRF Gene - From: DISEASES

Disorder Aliases PubMed IDs
epidemic typhus
  • sylvatic typhus
uremic neuropathy
benign paroxysmal positional nystagmus
  • benign paroxysmal positional vertigo
multiple symmetric lipomatosis
  • cervical symmetrical lipomatosis
rocky mountain spotted fever
  • brazillian spotted
- elite association - COSMIC cancer census association via MalaCards
Search MRRF in MalaCards View complete list of genes associated with diseases

Relevant External Links for MRRF

Genetic Association Database (GAD)
MRRF
Human Genome Epidemiology (HuGE) Navigator
MRRF
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRRF
genes like me logo Genes that share disorders with MRRF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRRF Gene

Publications for MRRF Gene

  1. Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor. (PMID: 9838146) Zhang Y. … Spremulli L.L. (Biochim. Biophys. Acta 1998) 2 3 4 23 67
  2. Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1-->q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32-->q34.1 with radiation hybrid mapping. (PMID: 10773675) Hansen L.L. … Justesen J. (Cytogenet. Cell Genet. 2000) 2 3 23
  3. The human mitochondrial ribosome recycling factor is essential for cell viability. (PMID: 18782833) Rorbach J. … Chrzanowska-Lightowlers Z.M. (Nucleic Acids Res. 2008) 3 23
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for MRRF Gene

Sources for MRRF Gene

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