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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRRF Gene

protein-coding   GIFtS: 57
GCID: GC09P125026

Mitochondrial Ribosome Recycling Factor

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrial Ribosome Recycling Factor1 2
RRF2 3 5
Ribosome-Releasing Factor, Mitochondrial2 3
MRFF2 5
MTRRF2
Ribosome-Recycling Factor, Mitochondrial2

External Ids:    HGNC: 72341   Entrez Gene: 923992   Ensembl: ENSG000001481877   OMIM: 6046025   UniProtKB: Q96E113   

Export aliases for MRRF gene to outside databases

Previous GC identifers: GC09U990093 GC09P116679 GC09P118480 GC09P120409 GC09P120403 GC09P122106 GC09P124066 GC09P094641


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for MRRF Gene: 
MRRF (mitochondrial ribosome recycling factor) is a protein-coding gene. Diseases associated with MRRF include end stage renal failure, and lyme disease.

UniProtKB/Swiss-Prot: RRFM_HUMAN, Q96E11
Function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.
May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRRF gene promoter:
         Sox5   FOXF2   POU3F1   FOXD3   E47   POU2F1   POU2F1b   POU2F1a   Hand1   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRRF promoter sequence
   Search SABiosciences Chromatin IP Primers for MRRF

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRRF


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.2   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q32-q34.1

MRRF Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRRF gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P125026:  view genomic region     (about GC identifiers)

Start:
125,026,882 bp from pter      End:
125,085,743 bp from pter
Size:
58,862 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RRFM_HUMAN, Q96E11 (See protein sequence)
Recommended Name: Ribosome-recycling factor, mitochondrial precursor  
Size: 262 amino acids; 29277 Da
Subcellular location: Mitochondrion (By similarity)
Secondary accessions: A8K6D8 A8K6Z4 B7Z4X5 B7Z6P7 Q5RKT1 Q5T7T0 Q5T7T1 Q5T7T2 Q5T7T3 Q5T7T4
Q5T7T5
Alternative splicing: 8 isoforms:  Q96E11-1   Q96E11-2   Q96E11-3   Q96E11-4   Q96E11-5   Q96E11-6   Q96E11-7   Q96E11-8   
(Derived from EST data. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MRRF: NX_Q96E11

Explore proteomics data for MRRF at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96E11

  • MRRF Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MRRF Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001166983.1  NP_620132.1  NP_954646.1  

    ENSEMBL proteins: 
     ENSP00000343867   ENSP00000395072   ENSP00000362834   ENSP00000362832   ENSP00000362833  
     ENSP00000434807   ENSP00000362829   ENSP00000433288   ENSP00000436360   ENSP00000297908  
     ENSP00000362828   ENSP00000377850   ENSP00000362835   ENSP00000445588  

    Human Recombinant Protein Products for MRRF: 
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    OriGene Protein Over-expression Lysate for MRRF
    OriGene MassSpec for MRRF 
    OriGene Custom Protein Services for MRRF
    GenScript Custom Purified and Recombinant Proteins Services for MRRF
    Novus Biologicals MRRF Proteins
    Novus Biologicals MRRF Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for MRRF
    Cloud-Clone Corp. Proteins for MRRF 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    MRRF for ontologies           About GeneDecksing



    MRRF Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for MRRF 

    Assay Products for MRRF: 
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    Cloud-Clone Corp. ELISAs for MRRF 
    Cloud-Clone Corp. CLIAs for MRRF


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR002661 Ribosome_recyc_fac
     IPR024946 Arg_repress_C-like
     IPR023584 Ribosome_recyc_fac_dom

    Graphical View of Domain Structure for InterPro Entry Q96E11

    ProtoNet protein and cluster: Q96E11

    1 Blocks protein domain: IPB002661 Ribosome recycling factor

    UniProtKB/Swiss-Prot: RRFM_HUMAN, Q96E11
    Similarity: Belongs to the RRF family


    MRRF for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RRFM_HUMAN, Q96E11
    Function: Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis.
    May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By
    similarity)

         Genatlas biochemistry entry for MRRF:
    mitochondrial ribosome recycling factor,mitochondrial translational factor 1,widely expressed

    Phenotypes:
         1 GenomeRNAi human phenotype for MRRF:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MRRF 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for MRRF

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MRRF 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MRRF 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRRF
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MRRF:
    hsa-miR-24-2* hsa-miR-24-1* hsa-miR-2278 hsa-miR-323b-5p
    SwitchGear 3'UTR luciferase reporter plasmidMRRF 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): MRRF (NM_138777)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRRF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRRF
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                         Customized lentivirus expression plasmids for stable overexpression of MRRF 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRRF


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRRF

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/268 Interacting proteins for MRRF (Q96E112, 3 ENSP000002979084) via UniProtKB, MINT, STRING, and/or I2D (see all 268)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ECH1Q130112, 3MINT-8079030 I2D: score=4 
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    MRPS11P829122, ENSP000003173764MINT-8079030 STRING: ENSP00000317376
    MRPL20Q9BYC92, ENSP000003410824MINT-8079030 STRING: ENSP00000341082
    MRPS14O607832, ENSP000004207144MINT-8079030 STRING: ENSP00000420714
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation IEA--
    GO:0032790ribosome disassembly IDA19716793

    MRRF for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRRF (RRFM)

    Search CenterWatch for drugs/clinical trials and news about MRRF / RRFM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRRF gene (4 alternative transcripts): 
    NM_199176.1  NM_001173512.1  NM_138777.3  NM_199177.2  

    Unigene Cluster for MRRF:

    Mitochondrial ribosome recycling factor
    Hs.368011  [show with all ESTs]
    Unigene Representative Sequence: NM_138777
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344641(uc010mwa.3 uc004bme.3 uc022bmy.1) ENST00000441707
    ENST00000373729 ENST00000373727 ENST00000373728(uc011lyq.2) ENST00000470366(uc010mvz.2)
    ENST00000373724 ENST00000467864 ENST00000489572 ENST00000297908(uc011lyr.2)
    ENST00000373723 ENST00000394315 ENST00000373730 ENST00000546115
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRRF
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MRRF:
    hsa-miR-24-2* hsa-miR-24-1* hsa-miR-2278 hsa-miR-323b-5p
    SwitchGear 3'UTR luciferase reporter plasmidMRRF 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MRRF
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRRF
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    OriGene ORF clones in mouse, rat for MRRF
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRRF
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRRF
    Sirion Biotech Customized lentivirus for stable overexpression of MRRF 
                         Customized lentivirus expression plasmids for stable overexpression of MRRF 
    Primer
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    OriGene qPCR primer pairs and template standards for MRRF
    OriGene qSTAR qPCR primer pairs in human, mouse for MRRF
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRRF
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRRF

    Additional mRNA sequence: 

    AK291603.1 AK291809.1 AK292790.1 AK298046.1 AK300718.1 AK310974.1 AK316266.1 BC002814.2 
    BC013049.1 BC053604.1 

    18 DOTS entries:

    DT.92436015  DT.95179518  DT.99934137  DT.100807554  DT.100807551  DT.116034  DT.100807553  DT.92436021 
    DT.100036188  DT.40119846  DT.95319821  DT.121172506  DT.121172584  DT.121172617  DT.121172568  DT.40287695 
    DT.91830351  DT.92436016 

    24/230 AceView cDNA sequences (see all 230):

    AA309964 BU192488 AA115320 AA768644 CA446671 W74755 BC053604 CB158413 
    AA428246 BE327990 CD643392 BU543762 AA430633 CA429471 NM_138777 AI299251 
    BC002814 AA970856 BF173103 CB528654 BI756457 AA829871 BQ019425 CA405882 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for MRRF (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b
    SP1:                    -     -     -     -                       -           -     -                     
    SP2:                                                              -           -     -                     
    SP3:                    -                                                                                 
    SP4:                    -     -     -                                                                     
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for MRRF

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRRF expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGTTTTCTC
    MRRF Expression
    About this image


    See MRRF Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRRF

    SOURCE GeneReport for Unigene cluster: Hs.368011
        SABiosciences Custom PCR Arrays for MRRF
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRRF

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MRRF gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrrf1 , 5 mitochondrial ribosome recycling factor1, 5 86.77(n)1
    85.11(a)1
      2 (24.19 cM)5
    678711  NM_026422.21  NP_080698.11 
     361363895 
    chicken
    (Gallus gallus)
    Aves MRRF1 mitochondrial ribosome recycling factor 67.82(n)
    62.16(a)
      417110  XM_003642298.1  XP_003642346.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BI442091.12   -- 73.86(n)    BI442091.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mrrf1 mitochondrial ribosome recycling factor 65.87(n)
    67.46(a)
      431721  NM_001002174.1  NP_001002174.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG44471 CG4447 49.6(n)
    38.28(a)
      39067  NM_140045.2  NP_648302.2 
    worm
    (Caenorhabditis elegans)
    Secernentea mrrf-16
    Probable ribosome-recycling factor, mitochondrial
    21(a)
    1 ↔ 1
    I(3909628-3910544)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G018001 ribosome recycling factor 44.05(n)
    28.07(a)
      821076  NM_111046.4  NP_186829.3 
    rice
    (Oryza sativa)
    Liliopsida Os04g04904001 hypothetical protein 42.59(n)
    28.28(a)
      4336241  NM_001059698.1  NP_001053163.1 


    ENSEMBL Gene Tree for MRRF (if available)
    TreeFam Gene Tree for MRRF (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRRF gene
    1 SIMAP similar gene for MRRF using alignment to 1 protein entry:     RRFM_HUMAN:
    MRRFP1

    MRRF for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1020 SNPs in MRRF are shown (see all 1020)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1807544111,2
    --125029148(+) GGGGTC/TGAGAC 2 -- int10--------
    rs1467002791,2
    C--125029222(+) CGCACA/GCCTGT 2 -- int10--------
    rs1847704941,2
    --125029285(+) CGGAGA/GTTGCA 2 -- int10--------
    rs1896829991,2
    --125029343(+) GACTCA/CGTCTC 2 -- int10--------
    rs70245531,2
    C,F,A--125029399(+) acgccA/G/Tgtaat 2 -- int15NA WA CSA 10
    rs1137990521,2
    C,F--125029445(+) CTGAGG/ATAAGG 2 -- int11Minor allele frequency- A:0.50WA 2
    rs70242681,2
    C,F,A--125029448(+) aggtaG/Aggagt 2 -- int11Minor allele frequency- A:0.50WA 2
    rs1858512971,2
    --125029547(+) CCCACC/TTACTC 2 -- int10--------
    rs1909951801,2
    C--125029574(+) AGAATA/CCCCTG 2 -- int10--------
    rs1818296781,2
    --125029601(+) GTTGCA/GGTGAG 2 -- int10--------

    HapMap Linkage Disequilibrium report for MRRF (125026882 - 125085743 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MRRF:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv6703CNV Insertion18451855
    nsv831716CNV Gain17160897


    Human Gene Mutation Database (HGMD): MRRF
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MRRF
    DNA2.0 Custom Variant and Variant Library Synthesis for MRRF

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604602    OMIM disorders: --

    6 diseases for MRRF:    About MalaCards
    end stage renal failure    lyme disease    lactic acidosis    peritonitis
    pneumonia    tuberculosis


    MRRF for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRRF
    Human Genome Epidemiology (HuGE) Navigator: MRRF (2 documents)

    Export disorders for MRRF gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRRF gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with MRRF)
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    world of online information

    1. Identification and cloning of human mitochondrial translational release factor 1 and the ribosome recycling factor. (PubMed id 9838146)1, 2, 3, 9 Zhang Y. and Spremulli L.L. (1998)
    2. Assignment of the human mitochondrial translational release factor 1 (MTRF1) to chromosome 13q14.1-->q14.3 and of the human mitochondrial ribosome recycling factor (MRRF) to chromosome 9q32-->q34.1 with radiation hybrid mapping. (PubMed id 10773675)1, 3, 9 Hansen L.L....Justesen J. (2000)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The human mitochondrial ribosome recycling factor is essential for cell viability. (PubMed id 18782833)1, 9 Rorbach J....Chrzanowska-Lightowlers Z.M. (2008)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92399 HGNC: 7234 AceView: MRRF Ensembl:ENSG00000148187 euGenes: HUgn92399
    ECgene: MRRF H-InvDB: MRRF

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRRF Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRRF gene:
    Search GeneIP for patents involving MRRF

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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