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Aliases for MRPS9 Gene

Aliases for MRPS9 Gene

  • Mitochondrial Ribosomal Protein S9 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein US9m 3 4
  • 28S Ribosomal Protein S9, Mitochondrial 2 3
  • MRP-S9 3 4
  • RPMS9 3 4
  • S9mt 3 4

External Ids for MRPS9 Gene

Previous GeneCards Identifiers for MRPS9 Gene

  • GC02P103518
  • GC02P104107
  • GC02P105259
  • GC02P105275
  • GC02P105113
  • GC02P105654
  • GC02P099424

Summaries for MRPS9 Gene

Entrez Gene Summary for MRPS9 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS9 Gene

MRPS9 (Mitochondrial Ribosomal Protein S9) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Additional gene information for MRPS9 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS9 Gene

Genomics for MRPS9 Gene

GeneHancer (GH) Regulatory Elements for MRPS9 Gene

Promoters and enhancers for MRPS9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I105037 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 564.4 +0.2 184 2.1 HDGF PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 POLR2B MRPS9 LOC102724691 TGFBRAP1
GH02I105080 Enhancer 1.5 VISTA UCNEbase Ensembl ENCODE 38.1 +43.2 43227 1 MXI1 POLR2A ZBTB6 SCRT2 CTBP2 FOXP2 MRPS9 GC02P105097 LOC102724691
GH02I105102 Enhancer 0.9 Ensembl ENCODE 35.6 +65.5 65542 1.8 MAX SIN3A POLR2A SCRT2 ZNF143 PRDM10 FOS KLF8 EGR2 SP3 LOC105373527 UTAT33 MRPS9 LINC01918
GH02I105052 Enhancer 0.7 ENCODE 38.1 +15.2 15215 0.8 SOX13 FEZF1 ZNF644 RARA CHAMP1 NR2F6 TCF7L2 GATAD2A SP5 NFIA MRPS9 LOC102724691 GC02P105097
GH02I104845 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 10.5 -192.8 -192760 0.6 KLF17 ZNF335 GLIS2 SP3 ZNF398 ZEB2 ZNF843 ZNF341 ZBTB26 ZBTB17 POU3F3 MRPS9 LINC01158 GPR45 GC02M104827
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MRPS9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPS9 gene promoter:

Genomic Locations for MRPS9 Gene

Genomic Locations for MRPS9 Gene
chr2:105,037,983-105,099,960
(GRCh38/hg38)
Size:
61,978 bases
Orientation:
Plus strand
chr2:105,654,441-105,716,418
(GRCh37/hg19)

Genomic View for MRPS9 Gene

Genes around MRPS9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS9 Gene

Proteins for MRPS9 Gene

  • Protein details for MRPS9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82933-RT09_HUMAN
    Recommended name:
    28S ribosomal protein S9, mitochondrial
    Protein Accession:
    P82933
    Secondary Accessions:
    • Q6PG40

    Protein attributes for MRPS9 Gene

    Size:
    396 amino acids
    Molecular mass:
    45835 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS9 Gene

neXtProt entry for MRPS9 Gene

Post-translational modifications for MRPS9 Gene

Other Protein References for MRPS9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS9 Gene

Domains & Families for MRPS9 Gene

Gene Families for MRPS9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for MRPS9 Gene

Graphical View of Domain Structure for InterPro Entry

P82933

UniProtKB/Swiss-Prot:

RT09_HUMAN :
  • Belongs to the universal ribosomal protein uS9 family.
Family:
  • Belongs to the universal ribosomal protein uS9 family.
genes like me logo Genes that share domains with MRPS9: view

Function for MRPS9 Gene

Gene Ontology (GO) - Molecular Function for MRPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 22190034
genes like me logo Genes that share ontologies with MRPS9: view
genes like me logo Genes that share phenotypes with MRPS9: view

Animal Model Products

CRISPR Products

miRNA for MRPS9 Gene

miRTarBase miRNAs that target MRPS9

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS9 Gene

Localization for MRPS9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS9 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS9 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (4)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MRPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion IDA,IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit NAS 11279123
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS9: view

Pathways & Interactions for MRPS9 Gene

genes like me logo Genes that share pathways with MRPS9: view

Gene Ontology (GO) - Biological Process for MRPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006412 translation IBA --
GO:0042769 DNA damage response, detection of DNA damage NAS 15300802
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS9: view

No data available for SIGNOR curated interactions for MRPS9 Gene

Drugs & Compounds for MRPS9 Gene

No Compound Related Data Available

Transcripts for MRPS9 Gene

Unigene Clusters for MRPS9 Gene

Mitochondrial ribosomal protein S9:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS9 Gene

No ASD Table

Relevant External Links for MRPS9 Gene

GeneLoc Exon Structure for
MRPS9
ECgene alternative splicing isoforms for
MRPS9

Expression for MRPS9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS9 Gene

Protein differential expression in normal tissues from HIPED for MRPS9 Gene

This gene is overexpressed in Lung (33.0) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS9 Gene



Protein tissue co-expression partners for MRPS9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS9 Gene:

MRPS9

SOURCE GeneReport for Unigene cluster for MRPS9 Gene:

Hs.590900

Evidence on tissue expression from TISSUES for MRPS9 Gene

  • Liver(4.3)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with MRPS9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS9 Gene

Orthologs for MRPS9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPS9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS9 33 34
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia MRPS9 33 34
  • 86.67 (n)
rat
(Rattus norvegicus)
Mammalia Mrps9 33
  • 81.2 (n)
mouse
(Mus musculus)
Mammalia Mrps9 33 16 34
  • 80.34 (n)
cow
(Bos Taurus)
Mammalia MRPS9 33 34
  • 79.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS9 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPS9 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS9 33 34
  • 71.09 (n)
lizard
(Anolis carolinensis)
Reptilia MRPS9 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps9 33
  • 68.4 (n)
zebrafish
(Danio rerio)
Actinopterygii mrps9 33 34
  • 59.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpS9 35 33 34
  • 52.27 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010268 33
  • 51.3 (n)
worm
(Caenorhabditis elegans)
Secernentea mrps-9 33 34
  • 44.9 (n)
F09G8.3 35
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPS9 34 36
  • 28 (a)
OneToOne
Species where no ortholog for MRPS9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS9 Gene

ENSEMBL:
Gene Tree for MRPS9 (if available)
TreeFam:
Gene Tree for MRPS9 (if available)

Paralogs for MRPS9 Gene

No data available for Paralogs for MRPS9 Gene

Variants for MRPS9 Gene

Sequence variations from dbSNP and Humsavar for MRPS9 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000013088 -- 105,056,057(+) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000028147 -- 105,046,587(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000031865 -- 105,089,363(+) G/T intron_variant
rs1000032730 -- 105,098,609(+) G/A intron_variant
rs1000048040 -- 105,053,112(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS9 Gene

Variant ID Type Subtype PubMed ID
dgv6983n54 CNV loss 21841781
dgv6984n54 CNV loss 21841781
dgv85e180 CNV loss 20482838
dgv86e180 CNV deletion 20482838
esv2663750 CNV deletion 23128226
esv2720474 CNV deletion 23290073
esv2720475 CNV deletion 23290073
esv2720476 CNV deletion 23290073
esv2720477 CNV deletion 23290073
esv2720478 CNV deletion 23290073
esv2720479 CNV deletion 23290073
esv27425 CNV loss 19812545
esv2842792 CNV deletion 24192839
esv3346284 CNV insertion 20981092
esv3559884 CNV deletion 23714750
esv3591824 CNV loss 21293372
nsv1013096 CNV loss 25217958
nsv472394 CNV novel sequence insertion 20440878
nsv582576 CNV loss 21841781
nsv820123 CNV gain 19587683

Variation tolerance for MRPS9 Gene

Residual Variation Intolerance Score: 57.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS9 Gene

Disorders for MRPS9 Gene

Additional Disease Information for MRPS9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPS9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS9 Gene

Publications for MRPS9 Gene

  1. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 2 3 4 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress. (PMID: 26472337) Zhu X … Wellmann S (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016) 3 58

Products for MRPS9 Gene

Sources for MRPS9 Gene

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