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Aliases for MRPS9 Gene

Aliases for MRPS9 Gene

  • Mitochondrial Ribosomal Protein S9 2 3 5
  • MRP-S9 3 4
  • RPMS9 3 4
  • S9mt 3 4
  • 28S Ribosomal Protein S9 2
  • Mitochondrial 2

External Ids for MRPS9 Gene

Previous GeneCards Identifiers for MRPS9 Gene

  • GC02P103518
  • GC02P104107
  • GC02P105259
  • GC02P105275
  • GC02P105113
  • GC02P105654
  • GC02P099424

Summaries for MRPS9 Gene

Entrez Gene Summary for MRPS9 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS9 Gene

MRPS9 (Mitochondrial Ribosomal Protein S9) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS9 Gene

Genomics for MRPS9 Gene

Regulatory Elements for MRPS9 Gene

Promoters for MRPS9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPS9 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPS9 Gene

Chromosome:
2
Start:
105,037,983 bp from pter
End:
105,099,960 bp from pter
Size:
61,978 bases
Orientation:
Plus strand

Genomic View for MRPS9 Gene

Genes around MRPS9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS9 Gene

Proteins for MRPS9 Gene

  • Protein details for MRPS9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82933-RT09_HUMAN
    Recommended name:
    28S ribosomal protein S9, mitochondrial
    Protein Accession:
    P82933
    Secondary Accessions:
    • Q6PG40

    Protein attributes for MRPS9 Gene

    Size:
    396 amino acids
    Molecular mass:
    45835 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS9 Gene

neXtProt entry for MRPS9 Gene

Proteomics data for MRPS9 Gene at MOPED

Post-translational modifications for MRPS9 Gene

  • Ubiquitination at Lys 119
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS9 Gene

Domains & Families for MRPS9 Gene

Gene Families for MRPS9 Gene

Suggested Antigen Peptide Sequences for MRPS9 Gene

Graphical View of Domain Structure for InterPro Entry

P82933

UniProtKB/Swiss-Prot:

RT09_HUMAN :
  • Belongs to the ribosomal protein S9P family.
Family:
  • Belongs to the ribosomal protein S9P family.
genes like me logo Genes that share domains with MRPS9: view

Function for MRPS9 Gene

genes like me logo Genes that share phenotypes with MRPS9: view

Animal Model Products

miRNA for MRPS9 Gene

miRTarBase miRNAs that target MRPS9

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS9 Gene

Localization for MRPS9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS9 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS9 Gene COMPARTMENTS Subcellular localization image for MRPS9 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2
chloroplast 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MRPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS9: view

Pathways & Interactions for MRPS9 Gene

genes like me logo Genes that share pathways with MRPS9: view

Gene Ontology (GO) - Biological Process for MRPS9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,IBA --
GO:0006996 organelle organization TAS --
genes like me logo Genes that share ontologies with MRPS9: view

No data available for SIGNOR curated interactions for MRPS9 Gene

Drugs & Compounds for MRPS9 Gene

No Compound Related Data Available

Transcripts for MRPS9 Gene

Unigene Clusters for MRPS9 Gene

Mitochondrial ribosomal protein S9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS9 Gene

No ASD Table

Relevant External Links for MRPS9 Gene

GeneLoc Exon Structure for
MRPS9
ECgene alternative splicing isoforms for
MRPS9

Expression for MRPS9 Gene

mRNA expression in normal human tissues for MRPS9 Gene

Protein differential expression in normal tissues from HIPED for MRPS9 Gene

This gene is overexpressed in Lung (33.0) and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS9 Gene



SOURCE GeneReport for Unigene cluster for MRPS9 Gene Hs.590900

genes like me logo Genes that share expression patterns with MRPS9: view

Protein tissue co-expression partners for MRPS9 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS9 Gene

Orthologs for MRPS9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPS9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPS9 35
  • 79.38 (n)
  • 76.57 (a)
MRPS9 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS9 35
  • 86.67 (n)
  • 83.04 (a)
MRPS9 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrps9 35
  • 80.34 (n)
  • 78.46 (a)
Mrps9 16
Mrps9 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPS9 35
  • 99.33 (n)
  • 99.49 (a)
MRPS9 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps9 35
  • 81.2 (n)
  • 79.23 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPS9 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS9 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS9 35
  • 71.09 (n)
  • 68.56 (a)
MRPS9 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPS9 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps9 35
  • 68.4 (n)
  • 65.36 (a)
zebrafish
(Danio rerio)
Actinopterygii mrps9 35
  • 59.49 (n)
  • 58.27 (a)
mrps9 36
  • 57 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mRpS9 37
  • 40 (a)
mRpS9 35
  • 52.27 (n)
  • 46.83 (a)
mRpS9 36
  • 42 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010268 35
  • 51.3 (n)
  • 43.48 (a)
worm
(Caenorhabditis elegans)
Secernentea F09G8.3 37
  • 33 (a)
mrps-9 35
  • 44.9 (n)
  • 36.56 (a)
mrps-9 36
  • 31 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPS9 36
  • 28 (a)
OneToOne
MRPS9 38
Species with no ortholog for MRPS9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS9 Gene

ENSEMBL:
Gene Tree for MRPS9 (if available)
TreeFam:
Gene Tree for MRPS9 (if available)

Paralogs for MRPS9 Gene

No data available for Paralogs for MRPS9 Gene

Variants for MRPS9 Gene

Sequence variations from dbSNP and Humsavar for MRPS9 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_047902 -
rs934235 -- 105,044,555(+) GAAAA(A/G)TAGCA intron-variant
rs2217420 -- 105,065,354(+) ATTTA(C/T)TTCAG intron-variant
rs3739156 -- 105,049,579(-) GTGTA(C/T)GAGCA intron-variant
rs3739157 -- 105,049,537(-) ACTCA(C/T)CATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS9 Gene

Variant ID Type Subtype PubMed ID
nsv820123 CNV Gain 19587683
dgv85e180 CNV Loss 20482838
dgv86e180 CNV Deletion 20482838
esv27425 CNV Loss 19812545
esv2663750 CNV Deletion 23128226
esv2720474 CNV Deletion 23290073
esv2720475 CNV Deletion 23290073
esv2720476 CNV Deletion 23290073
esv2720477 CNV Deletion 23290073
esv2720478 CNV Deletion 23290073
esv2720479 CNV Deletion 23290073

Variation tolerance for MRPS9 Gene

Residual Variation Intolerance Score: 57.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS9 Gene

HapMap Linkage Disequilibrium report
MRPS9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS9 Gene

Disorders for MRPS9 Gene

Relevant External Links for MRPS9

Genetic Association Database (GAD)
MRPS9
Human Genome Epidemiology (HuGE) Navigator
MRPS9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS9

No disorders were found for MRPS9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS9 Gene

Publications for MRPS9 Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4 67
  2. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for MRPS9 Gene

Sources for MRPS9 Gene

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