MRPS7 Gene
protein-coding GIFtS: 50
GCID: GC17P073254
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mitochondrial ribosomal protein S7
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Aliases
for MRPS7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein S71 2 | | S7mt2 3 | | MRP-S1 2 | | BMRP-27a1 | | RP-S71 2 | | BMRP27a1 | | RPMS71 2 | | 28S Ribosomal Protein S7, Mitochondrial2 | | MRP-S72 3 | | 30S Ribosomal Protein S7 Homolog2 |
Export aliases for MRPS7 gene to outside databasesPrevious GC identifers: GC17P076316 GC17P073721 GC17P073854 GC17P070769 GC17P068667 |
Summaries
for MRPS7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPS7:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein.In the prokaryotic ribosome, the comparable protein is thought to play an essential role in organizing the 3' domainof the 16 S rRNA in the vicinity of the P- and A-sites. Pseudogenes corresponding to this gene are found onchromosomes 8p and 12p. (provided by RefSeq, Jul 2008)
Gene Wiki entry for MRPS7
|
Genomic Views
for MRPS7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPS7 gene promoter:
Pax-2 Lmo2 Pax-2a AP-4 E47 c-Ets-1 GCNF-1 STAT3 c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPS7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.1MRPS7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P073254: view genomic region
(about GC identifiers)
Start:
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73,257,749 bp from pter |
End:
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73,262,457 bp from pter |
Size:
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4,709 bases |
Orientation:
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plus strand |
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Proteins
for MRPS7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RT07_HUMAN, Q9Y2R9 (See
protein sequence)Recommended Name: 28S ribosomal protein S7, mitochondrial precursor Size: 242 amino acids; 28134 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinctproteins (By similarity)
Subcellular location: Mitochondrion (By similarity)
Secondary accessions: B2R9N5 Q53GD6Explore the universe of human proteins at neXtProt for MRPS7: NX_Q9Y2R9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y2R9
MRPS7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057055.2
ENSEMBL proteins: ENSP00000463263 ENSP00000245539 ENSP00000463683 ENSP00000462677 ENSP00000463870 ENSP00000462506
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IDA | -- | | GO:0022627 | cytosolic small ribosomal subunit |
ISS | -- |
MRPS7 for ontologies About GeneDecksing
MRPS7 Antibody Products:
Assay Products for MRPS7: |
Protein
Domains /
Families
for MRPS7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPS7 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y2R9ProtoNet protein and cluster: Q9Y2R9 1 Blocks protein family: IPB000235 Ribosomal protein S7
UniProtKB/Swiss-Prot: RT07_HUMAN, Q9Y2R9Similarity: Belongs to the ribosomal protein S7P family |
Function
for MRPS7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS7 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRPS7 (NM_015971) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS7 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS7 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS7 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003723 | RNA binding |
ISS | -- | | GO:0003735 | structural constituent of ribosome |
ISS | -- |
MRPS7 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for MRPS7:
|
Pathways & Interactions
for MRPS7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MRPS7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/265 Interacting proteins for MRPS7 (Q9Y2R92, 3 ENSP000002455394) via UniProtKB, MINT, STRING, and/or I2D (see all 265)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006412 | translation |
ISS | -- |
MRPS7 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRPS7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPS7
Search CenterWatch for drugs/clinical trials and news about MRPS7 / RT07
|
Transcripts
for MRPS7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPS7 gene: NM_015971.3 Unigene Cluster for MRPS7: Mitochondrial ribosomal protein S7 Hs.71787 [show with all ESTs]Unigene Representative Sequence: NM_0159717 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000579761 ENST00000245539(uc002jnm.4) ENST00000579002 ENST00000583407
ENST00000577767 ENST00000581993 ENST00000584678
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS7 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRPS7 (NM_015971) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS7 |
Additional cDNA sequence: AF077042.1 AK222995.1 AK313854.1 BC000241.1 BC050641.2 13 DOTS entries: DT.456328 DT.100796358 DT.121005112 DT.100796364 DT.121005108 DT.121005222 DT.100021262 DT.91766614 DT.100796365 DT.121005172 DT.95173884 DT.100699845 DT.99975963 24/319 AceView cDNA sequences (see all 319): BQ227468 CR626657 BM470192 CR600124 CR615894 CR604496 CB269144 BE267532 BG475112 BE278110 BE743647 CR609316 CR620281 BE614899 BM784754 CR599341 BE615425 CR618302 BU608752 BM694974 BQ310641 BM459815 BF310435 BQ930311
GeneLoc Exon Structure
|
Expression
for MRPS7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPS7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGTGCAGCA
About this image
See MRPS7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPS7
SOURCE GeneReport for Unigene cluster: Hs.71787
SABiosciences Custom PCR Arrays for MRPS7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPS7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS7 |
Orthologs
for MRPS7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MRPS7 gene from 10/31 species (see all 31) About this table
ENSEMBL Gene Tree for MRPS7 (if available)
TreeFam Gene Tree for MRPS7 (if available) |
Paralogs
for MRPS7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRPS7 gene
MRPS7 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for MRPS7
PGOHUM00000262877 PGOHUM00000263191
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Genomic Variants
for MRPS7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPS7 (73257749 - 73262457 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MRPS7: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS7 |
|
Disorders
/ Diseases
for MRPS7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRPS7 for disorders About GeneDecksing
OMIM gene information: 611974
OMIM disorders: --
6  diseases for MRPS7: About MalaCardsdubin-johnson syndrome campylobacteriosis genetic disease pneumonia
tuberculosis mycobacterium tuberculosis
3 diseases from the University of Copenhagen DISEASES database for MRPS7:Dubin-Johnson syndrome Campylobacteriosis Pseudoxanthoma elasticum Human Genome Epidemiology (HuGE) Navigator: MRPS7 (1 document)
Export disorders for MRPS7 gene to outside databases
|
Publications
for MRPS7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPS7 gene, integrated from 9 sources (see all 36):
(articles sorted by number of sources associating them with MRPS7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2 Koc E.C.... Spremulli L.L. (2001)
- Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041)1, 2 Suzuki T....Watanabe K. (2001)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Identification of a mammalian mitochondrial homolog of ribosomal protein S7. (PubMed id 10581179)1, 2 Koc E.C.... Spremulli L.L. (1999)
- Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. (PubMed id 12706105)1, 9 Zhang Z. and Gerstein M. (2003)
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 9 Kenmochi N....Tanaka T. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
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External Searches for MRPS7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPS7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPS7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPS7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPS7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRPS7 gene:
Search GeneIP for patents involving MRPS7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPS7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRPS7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPS7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS7 | | | OriGene Protein Over-expression Lysate for MRPS7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRPS7 | | OriGene 3'-UTR Clone for MRPS7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MRPS7 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPS7 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS7 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS7 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPS7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS7 |
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 | | | MRPS7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS7 |
|  |  |  | | | | Search ThermoFisher Antibodies for MRPS7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS7 |
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