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Aliases for MRPS7 Gene

Aliases for MRPS7 Gene

  • Mitochondrial Ribosomal Protein S7 2 3
  • BMRP-27a 3 4
  • BMRP27a 3 4
  • MRP-S7 3 4
  • S7mt 3 4
  • 28S Ribosomal Protein S7, Mitochondrial 3
  • 30S Ribosomal Protein S7 Homolog 3
  • MRP-S 3
  • RP-S7 3
  • RPMS7 3

External Ids for MRPS7 Gene

Previous GeneCards Identifiers for MRPS7 Gene

  • GC17P073254
  • GC17P076316
  • GC17P073721
  • GC17P073854
  • GC17P070769
  • GC17P068667

Summaries for MRPS7 Gene

Entrez Gene Summary for MRPS7 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. In the prokaryotic ribosome, the comparable protein is thought to play an essential role in organizing the 3' domain of the 16 S rRNA in the vicinity of the P- and A-sites. Pseudogenes corresponding to this gene are found on chromosomes 8p and 12p. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS7 Gene

MRPS7 (Mitochondrial Ribosomal Protein S7) is a Protein Coding gene. Diseases associated with MRPS7 include campylobacteriosis and dubin-johnson syndrome. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPS7 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS7 Gene

Genomics for MRPS7 Gene

Regulatory Elements for MRPS7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPS7 Gene

75,261,668 bp from pter
75,266,376 bp from pter
4,709 bases
Plus strand

Genomic View for MRPS7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS7 Gene

Proteins for MRPS7 Gene

  • Protein details for MRPS7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S7, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B2R9N5
    • Q53GD6

    Protein attributes for MRPS7 Gene

    242 amino acids
    Molecular mass:
    28134 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

neXtProt entry for MRPS7 Gene

Proteomics data for MRPS7 Gene at MOPED

Post-translational modifications for MRPS7 Gene

  • Ubiquitination at Lys48, Lys125, Lys163, and Lys221
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS7 Gene

Antibody Products

No data available for DME Specific Peptides for MRPS7 Gene

Domains for MRPS7 Gene

Gene Families for MRPS7 Gene

Protein Domains for MRPS7 Gene

Suggested Antigen Peptide Sequences for MRPS7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S7P family.
  • Belongs to the ribosomal protein S7P family.
genes like me logo Genes that share domains with MRPS7: view

Function for MRPS7 Gene

Gene Ontology (GO) - Molecular Function for MRPS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding ISS --
GO:0003735 structural constituent of ribosome ISS --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPS7: view

Phenotypes for MRPS7 Gene

GenomeRNAi human phenotypes for MRPS7:
genes like me logo Genes that share phenotypes with MRPS7: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS7

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRPS7 Gene

Localization for MRPS7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS7 Gene


Subcellular locations from

Jensen Localization Image for MRPS7 Gene COMPARTMENTS Subcellular localization image for MRPS7 gene
Compartment Confidence
cytosol 4
mitochondrion 4
nucleus 2
plasma membrane 2
extracellular 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MRPS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0022627 cytosolic small ribosomal subunit ISS --
genes like me logo Genes that share ontologies with MRPS7: view

Pathways for MRPS7 Gene

SuperPathways for MRPS7 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
genes like me logo Genes that share pathways with MRPS7: view

Pathways by source for MRPS7 Gene

1 KEGG pathway for MRPS7 Gene

Gene Ontology (GO) - Biological Process for MRPS7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation ISS --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPS7: view

Transcripts for MRPS7 Gene

Unigene Clusters for MRPS7 Gene

Mitochondrial ribosomal protein S7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS7 Gene

No ASD Table

Relevant External Links for MRPS7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS7 Gene

mRNA expression in normal human tissues for MRPS7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MRPS7 Gene

This gene is overexpressed in Liver (9.9), Pancreas (9.2), and Lung (8.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS7 Gene

SOURCE GeneReport for Unigene cluster for MRPS7 Gene Hs.71787

genes like me logo Genes that share expressions with MRPS7: view

Expression partners for MRPS7 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS7 Gene

Orthologs for MRPS7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRPS7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS7 35
  • 87.6 (n)
  • 85.95 (a)
MRPS7 36
  • 86 (a)
(Canis familiaris)
Mammalia MRPS7 35
  • 86.64 (n)
  • 85.95 (a)
MRPS7 36
  • 86 (a)
(Mus musculus)
Mammalia Mrps7 35
  • 82.78 (n)
  • 84.71 (a)
Mrps7 16
Mrps7 36
  • 85 (a)
(Pan troglodytes)
Mammalia MRPS7 35
  • 99.17 (n)
  • 99.17 (a)
MRPS7 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mrps7 35
  • 82.51 (n)
  • 84.71 (a)
(Monodelphis domestica)
Mammalia MRPS7 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS7 36
  • 68 (a)
(Gallus gallus)
Aves MRPS7 35
  • 68.24 (n)
  • 66.95 (a)
MRPS7 36
  • 66 (a)
(Anolis carolinensis)
Reptilia MRPS7 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps7 35
  • 62.83 (n)
  • 64.16 (a)
Str.10836 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7175 35
(Danio rerio)
Actinopterygii mrps7 35
  • 64.48 (n)
  • 66.2 (a)
wufb66e05 35
mrps7 36
  • 63 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3540 35
fruit fly
(Drosophila melanogaster)
Insecta mRpS7 37
  • 41 (a)
mRpS7 35
  • 54.42 (n)
  • 46.99 (a)
mRpS7 36
  • 39 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009613 35
  • 55.44 (n)
  • 49.25 (a)
(Caenorhabditis elegans)
Secernentea mrps-7 35
  • 47.92 (n)
  • 37.02 (a)
mrps-7 36
  • 33 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons rps7 35
  • 42.89 (n)
  • 30.77 (a)
(Oryza sativa)
Liliopsida rps7 35
  • 41.96 (n)
  • 36.36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6785 36
  • 34 (a)
Species with no ortholog for MRPS7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS7 Gene

Gene Tree for MRPS7 (if available)
Gene Tree for MRPS7 (if available)

Paralogs for MRPS7 Gene Pseudogenes for MRPS7 Gene

genes like me logo Genes that share paralogs with MRPS7: view

No data available for Paralogs for MRPS7 Gene

Variants for MRPS7 Gene

Sequence variations from dbSNP and Humsavar for MRPS7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_030076 -
rs575948473 -- 75,265,300(+) CCCAA(A/T)GTGCT intron-variant
rs574717514 -- 75,264,506(+) TGTGT(C/T)CTCCT intron-variant
rs574014630 -- 75,264,681(+) TTTTT(C/T)TTTTT intron-variant
rs567430523 -- 75,265,695(+) TGTCT(A/C)ACCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS7 Gene

Variant ID Type Subtype PubMed ID
nsv908758 CNV Loss 21882294
nsv908760 CNV Loss 21882294
nsv510727 CNV Loss 20534489
nsv908761 CNV Loss 21882294

Relevant External Links for MRPS7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS7 Gene

Disorders for MRPS7 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MRPS7 Gene in MalaCards »

(2) Diseases for MRPS7 Gene

(3) University of Copenhagen DISEASES for MRPS7 Gene

Relevant External Links for MRPS7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MRPS7: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for MRPS7 Gene

Publications for MRPS7 Gene

  1. Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. (PMID: 12706105) Zhang Z. … Gerstein M. (Genomics 2003) 3 23
  2. Identification of a mammalian mitochondrial homolog of ribosomal protein S7. (PMID: 10581179) Koc E.C. … Spremulli L.L. (Biochem. Biophys. Res. Commun. 1999) 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 3 4
  5. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PMID: 11402041) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4

Products for MRPS7 Gene

Sources for MRPS7 Gene

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