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Aliases for MRPS6 Gene

Aliases for MRPS6 Gene

  • Mitochondrial Ribosomal Protein S6 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein BS6m 3 4
  • C21orf101 3 4
  • MRP-S6 3 4
  • RPMS6 3 4
  • S6mt 3 4
  • 28S Ribosomal Protein S6, Mitochondrial 3
  • Chromosome 21 Open Reading Frame 101 2

External Ids for MRPS6 Gene

Previous HGNC Symbols for MRPS6 Gene

  • C21orf101

Previous GeneCards Identifiers for MRPS6 Gene

  • GC21P032023
  • GC21P034366
  • GC21P034367
  • GC21P035446
  • GC21P035448
  • GC21P020976
  • GC21P035450
  • GC21P035452
  • GC21P035454
  • GC21P035456
  • GC21P035458
  • GC21P035460
  • GC21P034074
  • GC21P034076
  • GC21P034078
  • GC21P034081
  • GC21P034085

Summaries for MRPS6 Gene

Entrez Gene Summary for MRPS6 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS6 Gene

MRPS6 (Mitochondrial Ribosomal Protein S6) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome and small ribosomal subunit rRNA binding.

Gene Wiki entry for MRPS6 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS6 Gene

Genomics for MRPS6 Gene

Regulatory Elements for MRPS6 Gene

Enhancers for MRPS6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21G033935 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -134.8 -134772 5.8 BCOR ZNF146 ZMYM3 MAX CEBPG ZNF384 ZBTB40 ZKSCAN1 ZNF316 ADNP LINC00649 ATP5O MRPS6 SLC5A3 ENSG00000214955 GART SON ENSG00000249209 ENSG00000273102
GH21G034029 1.6 FANTOM5 Ensembl ENCODE 12.2 -43.1 -43084 0.9 HNRNPUL1 PKNOX1 ATF1 CREB3L1 ETS1 ELK1 ZNF143 FOS SP3 NFYC SLC5A3 MRPS6 ENSG00000214955 LINC00649 GART LOC105372789
GH21G033968 1.5 Ensembl ENCODE dbSUPER 11.4 -102.9 -102912 4.6 PKNOX1 CREB3L1 ARNT SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 FOS LINC00649 ATP5O MRPS6 SLC5A3 ENSG00000214955 ENSG00000273102 GC21M033955
GH21G034019 1.4 FANTOM5 Ensembl ENCODE 11.9 -51.2 -51184 5.5 HDGF TBP PKNOX1 RAD21 ZBTB40 GATA2 EGR1 FOS RELB ETV6 MRPS6 SLC5A3 ENSG00000214955 LINC00649 ATP5O GART SON LOC105372789
GH21G034128 1.4 FANTOM5 Ensembl ENCODE 9.2 +57.9 57874 5.4 PKNOX1 KLF17 ZNF2 RAD21 ZNF766 ZNF366 SCRT2 EGR2 ZNF362 TSHZ1 MRPS6 SLC5A3 RCAN1 RPS5P2 ENSG00000272657
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPS6 on UCSC Golden Path with GeneCards custom track

Promoters for MRPS6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000141652 776 2401 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF766 KLF13 SP3 SP5 REST

Genomic Location for MRPS6 Gene

Chromosome:
21
Start:
34,073,224 bp from pter
End:
34,143,034 bp from pter
Size:
69,811 bases
Orientation:
Plus strand

Genomic View for MRPS6 Gene

Genes around MRPS6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS6 Gene

Proteins for MRPS6 Gene

  • Protein details for MRPS6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82932-RT06_HUMAN
    Recommended name:
    28S ribosomal protein S6, mitochondrial
    Protein Accession:
    P82932
    Secondary Accessions:
    • B2R573
    • Q96Q64
    • Q9BSK8
    • Q9BW89

    Protein attributes for MRPS6 Gene

    Size:
    125 amino acids
    Molecular mass:
    14227 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
    SequenceCaution:
    • Sequence=BAB40995.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS6 Gene

neXtProt entry for MRPS6 Gene

Post-translational modifications for MRPS6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS6 Gene

Domains & Families for MRPS6 Gene

Gene Families for MRPS6 Gene

Protein Domains for MRPS6 Gene

Suggested Antigen Peptide Sequences for MRPS6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P82932

UniProtKB/Swiss-Prot:

RT06_HUMAN :
  • Belongs to the bacterial ribosomal protein bS6 family.
Family:
  • Belongs to the bacterial ribosomal protein bS6 family.
genes like me logo Genes that share domains with MRPS6: view

Function for MRPS6 Gene

Gene Ontology (GO) - Molecular Function for MRPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
GO:0005515 protein binding IPI 22458338
GO:0019843 rRNA binding IEA --
GO:0070181 small ribosomal subunit rRNA binding IBA --
genes like me logo Genes that share ontologies with MRPS6: view
genes like me logo Genes that share phenotypes with MRPS6: view

Animal Model Products

CRISPR Products

miRNA for MRPS6 Gene

miRTarBase miRNAs that target MRPS6

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS6 Gene

Localization for MRPS6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS6 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS6 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MRPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit ISS 11402041
GO:0005840 ribosome IEA --
GO:0015935 small ribosomal subunit NAS 11279123
genes like me logo Genes that share ontologies with MRPS6: view

Pathways & Interactions for MRPS6 Gene

genes like me logo Genes that share pathways with MRPS6: view

Gene Ontology (GO) - Biological Process for MRPS6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0032543 mitochondrial translation ISS 11402041
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS6: view

No data available for SIGNOR curated interactions for MRPS6 Gene

Drugs & Compounds for MRPS6 Gene

No Compound Related Data Available

Transcripts for MRPS6 Gene

Unigene Clusters for MRPS6 Gene

Mitochondrial ribosomal protein S6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS6 Gene

No ASD Table

Relevant External Links for MRPS6 Gene

GeneLoc Exon Structure for
MRPS6
ECgene alternative splicing isoforms for
MRPS6

Expression for MRPS6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS6 Gene

Protein differential expression in normal tissues from HIPED for MRPS6 Gene

This gene is overexpressed in Lung (25.5) and Breast (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS6 Gene



Protein tissue co-expression partners for MRPS6 Gene

NURSA nuclear receptor signaling pathways regulating expression of MRPS6 Gene:

MRPS6

SOURCE GeneReport for Unigene cluster for MRPS6 Gene:

Hs.302742

Evidence on tissue expression from TISSUES for MRPS6 Gene

  • Nervous system(4.9)
  • Kidney(4.4)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with MRPS6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS6 Gene

Orthologs for MRPS6 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS6 34
  • 100 (n)
SLC5A3 35
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS6 35
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100360017 34
  • 84.27 (n)
mouse
(Mus musculus)
Mammalia Mrps6 34 16 35
  • 84 (n)
cow
(Bos Taurus)
Mammalia MRPS6 34 35
  • 83.87 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPS6 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS6 35
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS6 34 35
  • 69.15 (n)
lizard
(Anolis carolinensis)
Reptilia MRPS6 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps6 34
  • 66.39 (n)
zebrafish
(Danio rerio)
Actinopterygii mrps6 34 35
  • 55.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpS6 35
  • 33 (a)
OneToOne
Species where no ortholog for MRPS6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS6 Gene

ENSEMBL:
Gene Tree for MRPS6 (if available)
TreeFam:
Gene Tree for MRPS6 (if available)

Paralogs for MRPS6 Gene

Pseudogenes.org Pseudogenes for MRPS6 Gene

genes like me logo Genes that share paralogs with MRPS6: view

No data available for Paralogs for MRPS6 Gene

Variants for MRPS6 Gene

Sequence variations from dbSNP and Humsavar for MRPS6 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000064656 -- 34,079,990(+) TCTTT(C/T)CCTGC intron-variant
rs1000090050 -- 34,093,571(+) AAGGA(A/G)AATGC intron-variant
rs1000156894 -- 34,079,854(+) TCCCC(G/T)TGGCA intron-variant
rs1000190074 -- 34,105,135(+) GGTAT(A/G)GAATT intron-variant, utr-variant-3-prime
rs1000196042 -- 34,101,557(+) CTGGT(C/G)TTTCT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPS6 Gene

Variant ID Type Subtype PubMed ID
dgv7820n54 CNV loss 21841781
dgv7821n54 CNV loss 21841781
dgv7822n54 CNV gain+loss 21841781
dgv7823n54 CNV gain 21841781
esv28721 CNV loss 19812545
esv3646915 CNV loss 21293372
esv3646916 CNV loss 21293372
esv3646917 CNV loss 21293372
nsv1073127 CNV deletion 25765185
nsv3499 CNV deletion 18451855
nsv438323 CNV loss 16468122
nsv587408 CNV loss 21841781
nsv587417 CNV loss 21841781
nsv587419 CNV loss 21841781
nsv953355 CNV deletion 24416366

Variation tolerance for MRPS6 Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.22; 24.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS6 Gene

Disorders for MRPS6 Gene

Relevant External Links for MRPS6

Genetic Association Database (GAD)
MRPS6
Human Genome Epidemiology (HuGE) Navigator
MRPS6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS6

No disorders were found for MRPS6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS6 Gene

Publications for MRPS6 Gene

  1. Ribosome. The structure of the human mitochondrial ribosome. (PMID: 25838379) Amunts A. … Ramakrishnan V. (Science 2015) 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Additive effect of multiple genetic variants on the risk of coronary artery disease. (PMID: 20738937) LluA-s-Ganella C. … Elosua R. (Rev Esp Cardiol 2010) 3 46 64
  4. A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. (PMID: 20971364) Ripatti S. … Kathiresan S. (Lancet 2010) 3 46 64
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 46 64

Products for MRPS6 Gene

Sources for MRPS6 Gene

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