MRPS6 Gene
protein-coding GIFtS : 49
GCID: GC21 P035458
mitochondrial ribosomal protein S6 (Previous name: chromosome 21 open reading frame 101 ) (Previous symbol: C21orf101 )
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Aliasesfor MRPS6 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Mitochondrial Ribosomal Protein S6 1 2 S6mt2 3 C21orf1011 2 3 Chromosome 21 Open Reading Frame 1011 MRP-S61 2 3 28S Ribosomal Protein S6, Mitochondrial2 RPMS61 2 3
Export aliases for MRPS6 gene to outside databases Previous GC identifers: GC21P032023 GC21P034366 GC21P034367 GC21P035446 GC21P035448 GC21P020976 GC21P035450 GC21P035452 GC21P035454 GC21P035456
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Summariesfor MRPS6 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MRPS6 : Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. (provided by RefSeq, Jul 2008) Gene Wiki entry for MRPS6
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Genomic Viewsfor MRPS6 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000021.8 NC_018932.1 NT_011512.11 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MRPS6 gene promoter: ISGF-3 GCNF FOXO3 LCR-F1 FOXO3b GATA-1 PPAR-gamma1 FOXO3a PPAR-gamma2 Other transcription factors Search SABiosciences Chromatin IP Primers for MRPS6 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MRPS6
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 21q22.11 Ensembl cytogenetic band: 21q22.11 HGNC cytogenetic band: 21q22.11 MRPS6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 21 GeneLoc Exon Structure
GeneLoc location for GC21P035458: view genomic region
(about GC identifiers )
Start:
35,445,524 bp from pter
End:
35,515,334 bp from pter
Size:
69,811 bases
Orientation:
plus strand
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Proteinsfor MRPS6 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RT06_HUMAN, P82932 (See
protein sequence )Recommended Name: 28S ribosomal protein S6, mitochondrial Size : 125 amino acids; 14227 Da
Subunit : Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinctproteins
Subcellular location : Mitochondrion
Sequence caution : Sequence=BAB40995.1; Type=Erroneous initiation;
Secondary accessions : B2R573 Q96Q64 Q9BSK8 Q9BW89Explore the universe of human proteins at neXtProt for MRPS6: NX_P82932 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P82932 MRPS6 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_115865.1 ENSEMBL proteins: ENSP00000382250 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
MRPS6 for ontologies About GeneDecksing MRPS6 Antibody Products: Assay Products for MRPS6:
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Protein
Domains / Familiesfor MRPS6 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MRPS6 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P82932 ProtoNet protein and cluster: P82932
1 Blocks protein family : IPB000529 Ribosomal protein S6 UniProtKB/Swiss-Prot: RT06_HUMAN, P82932 Similarity : Belongs to the ribosomal protein S6P family
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Functionfor MRPS6 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MRPS6 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MRPS6OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MRPS6 (NM_032476 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS6 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MRPS6
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS6
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
MRPS6 for ontologies About GeneDecksing
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Pathways & Interactionsfor MRPS6 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS6 STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)5/240 Interacting proteins for MRPS6 (P82932 2 , 3 ENSP00000382250 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 240 )About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
MRPS6 for ontologies About GeneDecksing
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Drugs & Compoundsfor MRPS6 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MRPS6 Search CenterWatch for drugs/clinical trials and news about MRPS6 / RT06
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Transcriptsfor MRPS6 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MRPS6 gene: NM_032476.3 Unigene Cluster for MRPS6:
Mitochondrial ribosomal protein S6 Hs.302742 [show with all ESTs ] Unigene Representative Sequence: NM_006933 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000488492 ENST00000399312 (uc002ytp.2 ) ENST00000477091 ENST00000483977 ENST00000482679 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MRPS6 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MRPS6OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MRPS6 (NM_032476 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS6 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MRPS6
Additional cDNA sequence: AB049942.1 AB074183.1 AK024896.1 AK026169.1 AK055913.1 AK092248.1 AK312084.1 AY061855.1 BC000547.2 BC004976.1 BC010076.2 BC051302.1 X83558.1
14 DOTS entries : DT.316613 DT.100780612
DT.117552 DT.443049 DT.121141792 DT.97844388 DT.100028351 DT.100028352 DT.95127516 DT.100740703 DT.92452025 DT.121141816 DT.100688983 DT.121141815 24/460 AceView cDNA sequences (see all 460 ):
AA029258 BM830659 N79574 BQ771747 AI332649 BM831419 AW241378 AI871766 AI280479 AI375330 CF128254 BI493912 AA570382 BE384048 C00620 BM713560 BQ071658 BX282240 BC042752 AI422744 BM563952 BU622555 AI014757 BQ232870 GeneLoc Exon Structure
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Expression for MRPS6 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MRPS6 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGGAAATAAA
About this image MRPS6 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Definitive endoderm-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See MRPS6 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MRPS6 SOURCE GeneReport for Unigene cluster: Hs.302742 SABiosciences Custom PCR Arrays for MRPS6 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MRPS6Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat MRPS6 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MRPS6 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MRPS6 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS6
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Orthologsfor MRPS6 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for MRPS6 gene from 5/15 species (see all 15 ) About this table
ENSEMBL Gene Tree for MRPS6 (if available)TreeFam Gene Tree for MRPS6 (if available)
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Paralogsfor MRPS6 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MRPS6 gene
MRPS6 for paralogs About GeneDecksing 3 Pseudogenes.org Pseudogenes for MRPS6 PGOHUM00000239884 PGOHUM00000243940 PGOHUM00000244714
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Genomic Variantsfor MRPS6 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 21 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MRPS6 (35445524 - 35515334 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for MRPS6 2 CNVs : 2006 73629
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MRPS6
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Disorders
/ Diseasesfor MRPS6 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MRPS6 for disorders About GeneDecksing
OMIM gene information: 611973
OMIM disorders : --2 diseases for MRPS6 : About MalaCards myocardial infarction gigantism Human Genome Epidemiology (HuGE) Navigator: MRPS6 (6 documents) Export disorders for MRPS6 gene to outside databases
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Publicationsfor MRPS6 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MRPS6 gene, integrated from 9 sources (see all 21 ): (articles sorted by number of sources associating them with MRPS6) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Nineteen additional unpredicted transcripts from human chromosome 21. (PubMed id 12036297) 1 , 2 Reymond A....Antonarakis S.E. (2002) The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634) 1 , 2 Kenmochi N....Tanaka T. (2001) Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041) 1 , 2 Suzuki T....Watanabe K. (2001) The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123) 1 , 2 Koc E.C.... Spremulli L.L. (2001) The DNA sequence of human chromosome 21. (PubMed id 10830953) 1 , 2 Hattori M....Yaspo M.L. (2000) Large-scale association analysis identifies 13 new su sceptibility loci for coronary artery disease. (PubMed id 21378990) 1 Schunkert H....Samani N.J. (2011) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049) 1 OlA!h J....OvA!di J. (2011)
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External Searches for MRPS6 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MRPS6 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MRPS6 gene
(According to HUGE )
About This Section --
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Specialized Databases showing MRPS6 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MRPS6 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MRPS6 gene: Search GeneIP for patents involving MRPS6 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MRPS6 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for MRPS6 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MRPS6 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MRPS6 OriGene Protein Over-expression Lysate for MRPS6 Browse OriGene Fluorogenic Cell Assay Kits Browse OriGene siRNAs OriGene 3'-UTR Clone for MRPS6 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MRPS6 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MRPS6 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for MRPS6 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MRPS6 OriGene Custom Protein Services for MRPS6 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPS6 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MRPS6 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MRPS6 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MRPS6 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MRPS6 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MRPS6
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MRPS6 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS6
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MRPS6
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Aliases for MRPS6
Databases for MRPS6
Disorders / Diseases for MRPS6
Domains / Families for MRPS6
Drugs / Compounds for MRPS6
Expression for MRPS6
Function for MRPS6
Genomic Views for MRPS6
Intellectual Property for MRPS6
Orthologs for MRPS6
Paralogs for MRPS6
Pathways / Interactions for MRPS6
Products for MRPS6
Proteins for MRPS6
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Summaries for MRPS6
Transcripts for MRPS6
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