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MRPS6 Gene

protein-coding   GIFtS: 52
GCID: GC21P035460

Mitochondrial Ribosomal Protein S6

(Previous name: chromosome 21 open reading frame 101)
(Previous symbol: C21orf101)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Ribosomal Protein S61 2     S6mt2 3
C21orf1011 2 3     Chromosome 21 Open Reading Frame 1011
MRP-S62 3     28S Ribosomal Protein S6, Mitochondrial2
RPMS62 3     

External Ids:    HGNC: 140511   Entrez Gene: 649682   Ensembl: ENSG000002439277   OMIM: 6119735   UniProtKB: P829323   

Export aliases for MRPS6 gene to outside databases

Previous GC identifers: GC21P032023 GC21P034366 GC21P034367 GC21P035446 GC21P035448 GC21P020976 GC21P035450 GC21P035452 GC21P035454 GC21P035456 GC21P035458


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRPS6 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are
found on chromosomes 1p and 12q. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPS6 Gene:
MRPS6 (mitochondrial ribosomal protein S6) is a protein-coding gene. GO annotations related to this gene include structural constituent of ribosome and rRNA binding.

Gene Wiki entry for MRPS6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRPS6 gene promoter:
         ISGF-3   GCNF   FOXO3   LCR-F1   FOXO3b   GATA-1   PPAR-gamma1   FOXO3a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPS6 promoter sequence
   Search Chromatin IP Primers for MRPS6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRPS6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.11

MRPS6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPS6 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21P035460:  view genomic region     (about GC identifiers)

Start:
35,445,524 bp from pter      End:
35,515,334 bp from pter
Size:
69,811 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RT06_HUMAN, P82932 (See protein sequence)
Recommended Name: 28S ribosomal protein S6, mitochondrial  
Size: 125 amino acids; 14227 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30
distinct proteins
Sequence caution: Sequence=BAB40995.1; Type=Erroneous initiation;
Secondary accessions: B2R573 Q96Q64 Q9BSK8 Q9BW89

Explore the universe of human proteins at neXtProt for MRPS6: NX_P82932

Explore proteomics data for MRPS6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MRPS6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115865.1  
    ENSEMBL proteins: 
     ENSP00000382250  

    MRPS6 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for MRPS6

     
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    antibodies-online proteins for MRPS6 (5 products) 

     
    antibodies-online peptides for MRPS6

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    antibodies-online kits for MRPS6 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MRPS: Mitochondrial ribosomal proteins / small subunits

    2 InterPro protein domains:
     IPR000529 Ribosomal_S6
     IPR014717 Transl_elong_EF1B/ribosomal_S6

    Graphical View of Domain Structure for InterPro Entry P82932

    ProtoNet protein and cluster: P82932

    1 Blocks protein domain: IPB000529 Ribosomal protein S6

    UniProtKB/Swiss-Prot: RT06_HUMAN, P82932
    Similarity: Belongs to the ribosomal protein S6P family


    Find genes that share domains with MRPS6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS11279123
    GO:0019843rRNA binding IEA--
         
    Find genes that share ontologies with MRPS6           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for MRPS6

    miRNA
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    miRTarBase miRNAs that target MRPS6:
    hsa-mir-17-5p (MIRT050858)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RT06_HUMAN, P82932: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005840ribosome ----
    GO:0015935small ribosomal subunit NAS11279123

    Find genes that share ontologies with MRPS6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MRPS6 About    
    See pathways by source

    SuperPathContained pathways About
    1CFTR translational fidelity class I mutations
    Ribosome0.54


    Find genes that share SuperPaths with MRPS6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for MRPS6):
        Ribosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRPS6
    Interactions:

        Search GeneGlobe Interaction Network for MRPS6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for MRPS6 (P829322, 3 ENSP000003822504) via UniProtKB, MINT, STRING, and/or I2D (see all 255)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KIAA1377Q9P2H02, 3MINT-64013 I2D: score=5 
    LRIF1Q5T3J32, 3MINT-64012 I2D: score=4 
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    SRRM2Q9UQ353, ENSP000003017404I2D: score=1 STRING: ENSP00000301740
    MRPS9P829332, ENSP000002584554MINT-8079030 STRING: ENSP00000258455
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation NAS11279123

    Find genes that share ontologies with MRPS6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRPS6 (RT06)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MRPS6 gene: 
    NM_032476.3  

    Unigene Cluster for MRPS6:

    Mitochondrial ribosomal protein S6
    Hs.302742  [show with all ESTs]
    Unigene Representative Sequence: NM_006933
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000488492 ENST00000399312(uc002ytp.2) ENST00000477091 ENST00000483977
    ENST00000482679
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat MRPS6

    Additional mRNA sequence: 

    AB049942.1 AB074183.1 AK024896.1 AK026169.1 AK055913.1 AK092248.1 AK312084.1 AY061855.1 
    BC000547.2 BC004976.1 BC010076.2 BC051302.1 X83558.1 

    14 DOTS entries:

    DT.316613  DT.117552  DT.100780612  DT.443049  DT.121141792  DT.97844388  DT.100028351  DT.100028352 
    DT.95127516  DT.100740703  DT.92452025  DT.121141815  DT.121141816  DT.100688983 

    Selected AceView cDNA sequences (see all 460):

    AI423415 BE384048 AI140453 AA029258 BX280448 AA688307 AI372882 BU156601 
    AW241378 BC042752 BE383056 AI991426 BQ232870 AI094106 BM705661 BM477310 
    CB128613 AI935495 CR590691 BG684737 AI014757 N91757 AI871766 AI422744 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRPS6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAAATAAA
    MRPS6 Expression
    About this image

    MRPS6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRPS6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.302742
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MRPS6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrps61 , 5 mitochondrial ribosomal protein S61, 5 84(n)1
    85.6(a)1
      16 (53.44 cM)5
    1210221  NM_080456.11  NP_536704.11 
     920582705 
    chicken
    (Gallus gallus)
    Aves MRPS61 mitochondrial ribosomal protein S6 69.15(n)
    66.94(a)
      427978  NM_001031486.1  NP_001026657.1 
    lizard
    (Anolis carolinensis)
    Reptilia MRPS66
    mitochondrial ribosomal protein S6
    66(a)
    1 ↔ 1
    3(142659415-142695274)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia mrps61 mitochondrial ribosomal protein S6 66.39(n)
    67.21(a)
      100038272  NM_001097389.1  NP_001090858.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mrps61 mitochondrial ribosomal protein S6 55.56(n)
    54.63(a)
      751746  NM_001045456.1  NP_001038921.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpS66
    mitochondrial ribosomal protein S6
    33(a)
    1 ↔ 1
    3L(4364550-4365243)


    ENSEMBL Gene Tree for MRPS6 (if available)
    TreeFam Gene Tree for MRPS6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MRPS6 gene

    Find genes that share paralogs with MRPS6           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for MRPS6
    PGOHUM00000239884 PGOHUM00000243940 PGOHUM00000244714


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MRPS6 (see all 820)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs124834011,2
    C,F,H--35443829(+) GTTAAT/CTGACA 1 -- us2k15Minor allele frequency- C:0.01NS EA NA 418
    rs356855231,2
    C--35469708(+) TGGGGA/-AAAAA 1 -- int11Minor allele frequency- -:0.00NA 2
    rs352805351,2
    C--35469726(+) ACTGTT/-GCATC 1 -- int13Minor allele frequency- -:0.00NA CSA 6
    rs114335581,2
    C--35475614(+) GAAGTA/-AAAAA 1 -- int12Minor allele frequency- -:0.25NA 4
    rs775485981,2
    C,F--35479198(+) CTACTT/ACTTGG 1 -- int12Minor allele frequency- A:0.04WA 120
    rs622121221,2
    C,F--35479240(+) TTTGGC/TGGTGG 1 -- int13Minor allele frequency- T:0.06WA NA EA 358
    rs801865811,2
    C--35479242(+) TGGCGC/GTGGAG 1 -- int10--------
    rs750975301,2
    C--35479244(+) GCGGTA/GGAGGG 1 -- int10--------
    rs790584671,2
    C--35479245(+) CGGTGG/TAGGGG 1 -- int10--------
    rs1408351761,2
    --35479265(+) TTGCTC/GTGTCG 1 -- int10--------

    HapMap Linkage Disequilibrium report for MRPS6 (35445524 - 35515334 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MRPS6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3499CNV Loss18451855
    nsv438323CNV Loss16468122
    esv28721CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRPS6
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPS6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611973    OMIM disorders: --


    Find genes that share disorders with MRPS6           About GenesLikeMe

    Genetic Association Database (GAD): MRPS6
    Human Genome Epidemiology (HuGE) Navigator: MRPS6 (6 documents)

    Export disorders for MRPS6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRPS6 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with MRPS6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses. (PubMed id 20971364)1, 4 Ripatti S....Kathiresan S. (Lancet 2010)
    2. Additive effect of multiple genetic variants on the risk of coronary artery disease. (PubMed id 20738937)1, 4 LluA-s-Ganella C....Elosua R. (Rev Esp Cardiol 2010)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    5. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. (PubMed id 19198609)1, 4  ....Altshuler D. (Nat. Genet. 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Nineteen additional unpredicted transcripts from human chromosome 21. (PubMed id 12036297)1, 2 Reymond A.... Antonarakis S.E. (Genomics 2002)
    9. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2 Kenmochi N.... Tanaka T. (Genomics 2001)
    10. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041)1, 2 Suzuki T....Watanabe K. (J. Biol. Chem. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64968 HGNC: 14051 AceView: SLC5A3 Ensembl:ENSG00000243927 euGenes: HUgn64968
    ECgene: MRPS6 Kegg: 64968 H-InvDB: MRPS6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRPS6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MRPS6 gene:
    Search GeneIP for patents involving MRPS6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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