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Aliases for MRPS5 Gene

Aliases for MRPS5 Gene

  • Mitochondrial Ribosomal Protein S5 2 3
  • Mitochondrial 28S Ribosomal Protein S5 2 3
  • MRP-S5 3 4
  • S5mt 3 4
  • 28S Ribosomal Protein S5, Mitochondrial 3

External Ids for MRPS5 Gene

Previous GeneCards Identifiers for MRPS5 Gene

  • GC02M093650
  • GC02M094186
  • GC02M095220
  • GC02M095237
  • GC02M095174
  • GC02M095752
  • GC02M089781

Summaries for MRPS5 Gene

Entrez Gene Summary for MRPS5 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS5 Gene

MRPS5 (Mitochondrial Ribosomal Protein S5) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPS5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS5 Gene

Genomics for MRPS5 Gene

Regulatory Elements for MRPS5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPS5 Gene

Start:
95,087,207 bp from pter
End:
95,149,434 bp from pter
Size:
62,228 bases
Orientation:
Minus strand

Genomic View for MRPS5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS5 Gene

Proteins for MRPS5 Gene

  • Protein details for MRPS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82675-RT05_HUMAN
    Recommended name:
    28S ribosomal protein S5, mitochondrial
    Protein Accession:
    P82675
    Secondary Accessions:
    • Q4ZFY5
    • Q96LJ6
    • Q9BWI4
    • Q9BYC4

    Protein attributes for MRPS5 Gene

    Size:
    430 amino acids
    Molecular mass:
    48006 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins

    Alternative splice isoforms for MRPS5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPS5 Gene

Proteomics data for MRPS5 Gene at MOPED

Post-translational modifications for MRPS5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS5 Gene

Domains for MRPS5 Gene

Gene Families for MRPS5 Gene

HGNC:
  • MRPS :Mitochondrial ribosomal proteins / small subunits

Suggested Antigen Peptide Sequences for MRPS5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P82675

UniProtKB/Swiss-Prot:

RT05_HUMAN :
  • P82675
Domain:
  • Contains 1 S5 DRBM domain.
Family:
  • Belongs to the ribosomal protein S5P family.
genes like me logo Genes that share domains with MRPS5: view

Function for MRPS5 Gene

Gene Ontology (GO) - Molecular Function for MRPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0003735 structural constituent of ribosome IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPS5: view

Phenotypes for MRPS5 Gene

GenomeRNAi human phenotypes for MRPS5:
genes like me logo Genes that share phenotypes with MRPS5: view

Animal Model Products

CRISPR Products

miRNA for MRPS5 Gene

miRTarBase miRNAs that target MRPS5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS5

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPS5 Gene

Localization for MRPS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS5 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS5 Gene COMPARTMENTS Subcellular localization image for MRPS5 gene
Compartment Confidence
mitochondrion 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MRPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IBA --
GO:0005840 ribosome --
GO:0022627 NOT cytosolic small ribosomal subunit IBA --
genes like me logo Genes that share ontologies with MRPS5: view

Pathways for MRPS5 Gene

SuperPathways for MRPS5 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with MRPS5: view

Pathways by source for MRPS5 Gene

1 KEGG pathway for MRPS5 Gene

Gene Ontology (GO) - Biological Process for MRPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPS5: view

Transcripts for MRPS5 Gene

Unigene Clusters for MRPS5 Gene

Mitochondrial ribosomal protein S5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS5 Gene

No ASD Table

Relevant External Links for MRPS5 Gene

GeneLoc Exon Structure for
MRPS5
ECgene alternative splicing isoforms for
MRPS5

Expression for MRPS5 Gene

mRNA expression in normal human tissues for MRPS5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS5 Gene

SOURCE GeneReport for Unigene cluster for MRPS5 Gene Hs.655259

genes like me logo Genes that share expressions with MRPS5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS5 Gene

Orthologs for MRPS5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPS5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS5 35
  • 99.69 (n)
  • 99.77 (a)
MRPS5 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPS5 35
  • 84.88 (n)
  • 82.09 (a)
MRPS5 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS5 35
  • 88.29 (n)
  • 84.88 (a)
MRPS5 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrps5 35
  • 80.7 (n)
  • 80.23 (a)
Mrps5 16
Mrps5 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPS5 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS5 36
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps5 35
  • 82.33 (n)
  • 81.16 (a)
chicken
(Gallus gallus)
Aves MRPS5 35
  • 67.51 (n)
  • 65.32 (a)
MRPS5 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPS5 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2711 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494239 35
  • 68.62 (n)
  • 68.09 (a)
Str.7009 35
zebrafish
(Danio rerio)
Actinopterygii mrps5 35
  • 62.64 (n)
  • 59.64 (a)
mrps5 36
  • 59 (a)
OneToOne
wufc73g02 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004091 35
  • 51.62 (n)
  • 44.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS5 35
  • 50.7 (n)
  • 44.37 (a)
mRpS5 36
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrps-5 35
  • 45.79 (n)
  • 38.79 (a)
mrps-5 36
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPS5 36
  • 23 (a)
OneToOne
MRPS5 38
Species with no ortholog for MRPS5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS5 Gene

ENSEMBL:
Gene Tree for MRPS5 (if available)
TreeFam:
Gene Tree for MRPS5 (if available)

Paralogs for MRPS5 Gene

Pseudogenes.org Pseudogenes for MRPS5 Gene

genes like me logo Genes that share paralogs with MRPS5: view

No data available for Paralogs for MRPS5 Gene

Variants for MRPS5 Gene

Sequence variations from dbSNP and Humsavar for MRPS5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs14487 -- 95,087,290(+) CCAAG(A/C)TGTGA utr-variant-3-prime
rs3105096 -- 95,120,438(-) ttggc(C/T)tccag intron-variant
rs3112222 -- 95,116,997(+) TTAGC(C/T)GGGTG intron-variant
rs3112227 -- 95,122,065(-) GCAGG(A/C)GCCAG upstream-variant-2KB
rs3112231 -- 95,105,351(-) GGATG(A/G)TCTCG intron-variant

Relevant External Links for MRPS5 Gene

HapMap Linkage Disequilibrium report
MRPS5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPS5 Gene

Disorders for MRPS5 Gene

No disorders were found for MRPS5 Gene.

No data available for UniProtKB/Swiss-Prot for MRPS5 Gene

Publications for MRPS5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PMID: 11402041) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4
  4. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 3 4
  5. Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach. (PMID: 11344316) Koc E.C. … Spremulli L.L. (Protein Sci. 2001) 3

Products for MRPS5 Gene

Sources for MRPS5 Gene

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