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Aliases for MRPS5 Gene

Aliases for MRPS5 Gene

  • Mitochondrial Ribosomal Protein S5 2 3 5
  • Mitochondrial 28S Ribosomal Protein S5 2 3
  • MRP-S5 3 4
  • S5mt 3 4

External Ids for MRPS5 Gene

Previous GeneCards Identifiers for MRPS5 Gene

  • GC02M093650
  • GC02M094186
  • GC02M095220
  • GC02M095237
  • GC02M095174
  • GC02M095752
  • GC02M089781

Summaries for MRPS5 Gene

Entrez Gene Summary for MRPS5 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS5 Gene

MRPS5 (Mitochondrial Ribosomal Protein S5) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPS5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS5 Gene

Genomics for MRPS5 Gene

Regulatory Elements for MRPS5 Gene

Enhancers for MRPS5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPS5 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPS5 Gene

95,087,207 bp from pter
95,149,434 bp from pter
62,228 bases
Minus strand

Genomic View for MRPS5 Gene

Genes around MRPS5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS5 Gene

Proteins for MRPS5 Gene

  • Protein details for MRPS5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S5, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q4ZFY5
    • Q96LJ6
    • Q9BWI4
    • Q9BYC4

    Protein attributes for MRPS5 Gene

    430 amino acids
    Molecular mass:
    48006 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS5 Gene

    Alternative splice isoforms for MRPS5 Gene


neXtProt entry for MRPS5 Gene

Proteomics data for MRPS5 Gene at MOPED

Post-translational modifications for MRPS5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS5 Gene

No data available for DME Specific Peptides for MRPS5 Gene

Domains & Families for MRPS5 Gene

Gene Families for MRPS5 Gene

Suggested Antigen Peptide Sequences for MRPS5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 S5 DRBM domain.
  • Belongs to the ribosomal protein S5P family.
  • Contains 1 S5 DRBM domain.
  • Belongs to the ribosomal protein S5P family.
genes like me logo Genes that share domains with MRPS5: view

Function for MRPS5 Gene

genes like me logo Genes that share phenotypes with MRPS5: view

Animal Models for MRPS5 Gene

MGI Knock Outs for MRPS5:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRPS5 Gene

Localization for MRPS5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS5 Gene


Subcellular locations from

Jensen Localization Image for MRPS5 Gene COMPARTMENTS Subcellular localization image for MRPS5 gene
Compartment Confidence
mitochondrion 5
cytosol 1
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MRPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPS5: view

Pathways & Interactions for MRPS5 Gene

genes like me logo Genes that share pathways with MRPS5: view

Gene Ontology (GO) - Biological Process for MRPS5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,IBA --
genes like me logo Genes that share ontologies with MRPS5: view

No data available for SIGNOR curated interactions for MRPS5 Gene

Drugs & Compounds for MRPS5 Gene

No Compound Related Data Available

Transcripts for MRPS5 Gene

Unigene Clusters for MRPS5 Gene

Mitochondrial ribosomal protein S5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS5 Gene

No ASD Table

Relevant External Links for MRPS5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS5 Gene

mRNA expression in normal human tissues for MRPS5 Gene

Protein differential expression in normal tissues from HIPED for MRPS5 Gene

This gene is overexpressed in Lung (25.7) and Breast (23.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS5 Gene

SOURCE GeneReport for Unigene cluster for MRPS5 Gene Hs.655259

genes like me logo Genes that share expression patterns with MRPS5: view

Protein tissue co-expression partners for MRPS5 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS5 Gene

Orthologs for MRPS5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPS5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS5 35
  • 84.88 (n)
  • 82.09 (a)
MRPS5 36
  • 82 (a)
(Canis familiaris)
Mammalia MRPS5 35
  • 88.29 (n)
  • 84.88 (a)
MRPS5 36
  • 85 (a)
(Mus musculus)
Mammalia Mrps5 35
  • 80.7 (n)
  • 80.23 (a)
Mrps5 16
Mrps5 36
  • 80 (a)
(Pan troglodytes)
Mammalia MRPS5 35
  • 99.69 (n)
  • 99.77 (a)
MRPS5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrps5 35
  • 82.33 (n)
  • 81.16 (a)
(Monodelphis domestica)
Mammalia MRPS5 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS5 36
  • 68 (a)
(Gallus gallus)
Aves MRPS5 35
  • 67.51 (n)
  • 65.32 (a)
MRPS5 36
  • 63 (a)
(Anolis carolinensis)
Reptilia MRPS5 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494239 35
  • 68.62 (n)
  • 68.09 (a)
Str.7009 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.2711 35
(Danio rerio)
Actinopterygii mrps5 35
  • 62.64 (n)
  • 59.64 (a)
wufc73g02 35
mrps5 36
  • 59 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004091 35
  • 51.62 (n)
  • 44.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS5 35
  • 50.7 (n)
  • 44.37 (a)
mRpS5 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea mrps-5 35
  • 45.79 (n)
  • 38.79 (a)
mrps-5 36
  • 29 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPS5 36
  • 23 (a)
MRPS5 38
Species with no ortholog for MRPS5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS5 Gene

Gene Tree for MRPS5 (if available)
Gene Tree for MRPS5 (if available)

Paralogs for MRPS5 Gene Pseudogenes for MRPS5 Gene

genes like me logo Genes that share paralogs with MRPS5: view

No data available for Paralogs for MRPS5 Gene

Variants for MRPS5 Gene

Sequence variations from dbSNP and Humsavar for MRPS5 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3105096 -- 95,120,438(+) ttggc(A/C/G/T)tccag intron-variant
rs3112222 -- 95,116,997(+) TTAGC(C/T)GGGTG intron-variant
rs3112227 -- 95,122,065(-) GCAGG(A/C)GCCAG upstream-variant-2KB
rs3112231 -- 95,105,351(-) GGATG(A/G)TCTCG intron-variant
rs3112991 -- 95,089,916(+) CTCAC(A/G)CCTGT intron-variant

Variation tolerance for MRPS5 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MRPS5 Gene

Disorders for MRPS5 Gene

Relevant External Links for MRPS5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPS5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS5 Gene

Publications for MRPS5 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for MRPS5 Gene

Sources for MRPS5 Gene