MRPS5 Gene
protein-coding GIFtS : 48
GCID: GC02 M095752
mitochondrial ribosomal protein S5
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Aliasesfor MRPS5 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Mitochondrial Ribosomal Protein S5 1 2 MRP-S51 2 3 S5mt1 2 3 28S Ribosomal Protein S5, Mitochondrial2 Mitochondrial 28S Ribosomal Protein S52
Export aliases for MRPS5 gene to outside databases Previous GC identifers: GC02M093650 GC02M094186 GC02M095220 GC02M095237 GC02M095174 GC02M089781
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Summariesfor MRPS5 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for MRPS5 : Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. (provided by RefSeq, Jul 2008) Gene Wiki entry for MRPS5
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Genomic Viewsfor MRPS5 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NC_018913.1 NT_022171.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MRPS5 gene promoter: E2F-3a E2F-4 E2F-5 Sp1 E2F-2 Arnt YY1 E2F-1 E2F ZID Other transcription factors Search SABiosciences Chromatin IP Primers for MRPS5 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MRPS5
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2p11.2-q11.2 Ensembl cytogenetic band: 2q11.1 HGNC cytogenetic band: 2p11.2-q11.2 MRPS5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M095752: view genomic region
(about GC identifiers )
Start:
95,752,952 bp from pter
End:
95,815,179 bp from pter
Size:
62,228 bases
Orientation:
minus strand
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Proteinsfor MRPS5 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: RT05_HUMAN, P82675 (See
protein sequence )Recommended Name: 28S ribosomal protein S5, mitochondrial Size : 430 amino acids; 48006 Da
Subunit : Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinctproteins
Subcellular location : Mitochondrion
Secondary accessions : Q4ZFY5 Q96LJ6 Q9BWI4 Q9BYC4Alternative splicing : 2 isoforms : P82675-1 P82675-2 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)Explore the universe of human proteins at neXtProt for MRPS5: NX_P82675 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P82675 MRPS5 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_114108.1 ENSEMBL proteins: ENSP00000272418 ENSP00000341660 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
MRPS5 for ontologies About GeneDecksing MRPS5 Antibody Products: Assay Products for MRPS5:
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Protein
Domains / Familiesfor MRPS5 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
MRPS5 for domains About GeneDecksing 5/7 InterPro domains/families (see all 7 ):
Graphical View of Domain Structure for InterPro Entry P82675 ProtoNet protein and cluster: P82675
1 Blocks protein family : IPB000851 Ribosomal protein S5 UniProtKB/Swiss-Prot: RT05_HUMAN, P82675 Similarity : Belongs to the ribosomal protein S5P familySimilarity : Contains 1 S5 DRBM domain
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Functionfor MRPS5 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MRPS5 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MRPS5 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MRPS5 (NM_031902 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MRPS5
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS5
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003723 RNA binding
IEA -- GO:0003735 structural constituent of ribosome
IEA --
MRPS5 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for MRPS5 :
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Pathways & Interactionsfor MRPS5 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS5 STRING Interaction
Network Preview (showing 5 interactants - click image to see 7)5/303 Interacting proteins for MRPS5 (P82675 2 , 3 ENSP00000272418 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 303 )About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0006412 translation
IEA --
MRPS5 for ontologies About GeneDecksing
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Drugs & Compoundsfor MRPS5 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for MRPS5 Search CenterWatch for drugs/clinical trials and news about MRPS5 / RT05
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Transcriptsfor MRPS5 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for MRPS5 gene: NM_031902.3 Unigene Cluster for MRPS5:
Mitochondrial ribosomal protein S5 Hs.655259 [show with all ESTs ] Unigene Representative Sequence: AK124892 8 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000272418 (uc002sub.3 uc002suc.3 ) ENST00000482821 ENST00000345084 ENST00000461916 ENST00000482568 ENST00000475895 (uc010yud.1 ) ENST00000464458 ENST00000475040 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MRPS5 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MRPS5 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: MRPS5 (NM_031902 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MRPS5
Additional cDNA sequence: AB049940.1 AK055390.1 AK058160.1 AK124892.1 AK295812.1 BC000219.2 BC014172.2
20 DOTS entries : DT.116533 DT.100810526
DT.101964818 DT.95180651 DT.100714430 DT.100029313 DT.100668738 DT.92010716 DT.103233 DT.95180688 DT.120994924 DT.40107295 DT.95180650 DT.95297012 DT.100029314 DT.100810533 DT.107353 DT.120994869 DT.95180685 DT.97848322 24/341 AceView cDNA sequences (see all 341 ):
BM805336 BX110540 CD105425 N85528 BM766450 BI760889 BQ887672 T32304 CA431688 AW007510 AB049940 AA928405 CD676163 BQ225061 BM668844 BC014172 BM720212 AA884605 Z39743 BC074901 BQ232746 BQ051036 AA669366 BQ637141 GeneLoc Exon Structure
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Expression for MRPS5 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section MRPS5 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTGTGGAAAT
About this image See MRPS5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MRPS5 SOURCE GeneReport for Unigene cluster: Hs.655259 SABiosciences Custom PCR Arrays for MRPS5 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MRPS5Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat MRPS5 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MRPS5 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MRPS5 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS5
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Orthologsfor MRPS5 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MRPS5 gene from 9/35 species (see all 35 ) About this table
ENSEMBL Gene Tree for MRPS5 (if available)TreeFam Gene Tree for MRPS5 (if available)
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Paralogsfor MRPS5 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for MRPS5 gene
MRPS5 for paralogs About GeneDecksing 3 Pseudogenes.org Pseudogenes for MRPS5 PGOHUM00000235080 PGOHUM00000245751 PGOHUM00000251331
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Genomic Variantsfor MRPS5 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 2 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for MRPS5 (95752952 - 95815179 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MRPS5: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MRPS5
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Disorders
/ Diseasesfor MRPS5 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
MRPS5 for disorders About GeneDecksing
OMIM gene information: 611972
OMIM disorders : --3 diseases for MRPS5 : About MalaCards pneumonia tuberculosis mycobacterium tuberculosis Export disorders for MRPS5 gene to outside databases
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Publicationsfor MRPS5 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for MRPS5 gene, integrated from 9 sources (see all 16 ): (articles sorted by number of sources associating them with MRPS5) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041) 1 , 2 Suzuki T....Watanabe K. (2001) The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123) 1 , 2 Koc E.C.... Spremulli L.L. (2001) A census of human soluble protein complexes. (PubMed id 22939629) 1 Havugimana P.C....Emili A. (2012) Initial characterization of the human central proteome. (PubMed id 21269460) 2 Burkard T.R.... Colinge J. (2011) Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048) 1 Danielsen J.M....Nielsen M.L. (2011) A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120) 1 Richter R....Chrzanowska-Lightowlers Z.M. (2010) Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461) 1 Bennett E.J....Harper J.W. (2010) Interactions of human ribosomal proteins S16 and S5 w ith an 18S rRNA fragment containing their binding sites. (PubMed id 19559069) 1 Malygin A.A....Karpova G.G. (2009)
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External Searches for MRPS5 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing MRPS5 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing MRPS5 gene
(According to HUGE )
About This Section --
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Specialized Databases showing MRPS5 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for MRPS5 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for MRPS5 gene: Search GeneIP for patents involving MRPS5 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor MRPS5 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for MRPS5 OriGene shRNA RFP for MRPS5 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for MRPS5 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for MRPS5 OriGene Protein Over-expression Lysate for MRPS5 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for MRPS5 OriGene 3'-UTR Clone for MRPS5 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for MRPS5 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for MRPS5 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for MRPS5 OriGene Custom Protein Services for MRPS5 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPS5 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing MRPS5 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat MRPS5 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat MRPS5 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat MRPS5 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat MRPS5
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MRPS5 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS5
ThermoFisher Antibodies for MRPS5
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat MRPS5
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Aliases for MRPS5
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Disorders / Diseases for MRPS5
Domains / Families for MRPS5
Drugs / Compounds for MRPS5
Expression for MRPS5
Function for MRPS5
Genomic Views for MRPS5
Intellectual Property for MRPS5
Orthologs for MRPS5
Paralogs for MRPS5
Pathways / Interactions for MRPS5
Products for MRPS5
Proteins for MRPS5
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Summaries for MRPS5
Transcripts for MRPS5
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