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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRPS36 Gene

protein-coding   GIFtS: 43
GCID: GC05P068514

Mitochondrial Ribosomal Protein S36

  Search for MRPS36
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrial Ribosomal Protein S361 2
MRP-S362 3
S36mt2 3
28S Ribosomal Protein S36, Mitochondrial2

External Ids:    HGNC: 166311   Entrez Gene: 922592   Ensembl: ENSG000001340567   OMIM: 6119965   UniProtKB: P829093   

Export aliases for MRPS36 gene to outside databases

Previous GC identifers: GC05P068665 GC05P070079 GC05P068485 GC05P068529 GC05P068549 GC05P065470


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRPS36 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. The mitochondrial ribosome (mitoribosome) consists of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
28S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 3p, 4q, 8p, 11q, 12q, and
20p. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPS36 Gene: 
MRPS36 (mitochondrial ribosomal protein S36) is a protein-coding gene. GO annotations related to this gene include structural constituent of ribosome.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_006713.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRPS36 gene promoter:
         GR   Elk-1   Sp1   AML1a   ATF-2   CBF-A   FOXC1   c-Jun   GR-alpha   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPS36 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRPS36

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS36


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.2   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13.2

MRPS36 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPS36 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P068514:  view genomic region     (about GC identifiers)

Start:
68,513,573 bp from pter      End:
68,525,985 bp from pter
Size:
12,413 bases      Orientation:
plus strand

1 alternative location:
Chr5+,NW_003315917.2 928-13,338     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RT36_HUMAN, P82909 (See protein sequence)
Recommended Name: 28S ribosomal protein S36, mitochondrial  
Size: 103 amino acids; 11466 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30
distinct proteins
Subcellular location: Mitochondrion
Secondary accessions: Q9H2H4

Explore the universe of human proteins at neXtProt for MRPS36: NX_P82909

Explore proteomics data for MRPS36 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P82909

  • MRPS36 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MRPS36 Protein Expression
    REFSEQ proteins: NP_150597.1  
    ENSEMBL proteins: 
     ENSP00000256441   ENSP00000423659   ENSP00000473310  

    Human Recombinant Protein Products for MRPS36: 
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    Cloud-Clone Corp. Proteins for MRPS36 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ISS--
    GO:0005763mitochondrial small ribosomal subunit IDA11279123

    MRPS36 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for MRPS36 
    Cloud-Clone Corp. CLIAs for MRPS36


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MRPS: Mitochondrial ribosomal proteins / small subunits

    ProtoNet protein and cluster: P82909


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS11279123
         
    MRPS36 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MRPS36 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MRPS36 
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    miRNA
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    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MRPS36:
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    SwitchGear 3'UTR luciferase reporter plasmidMRPS36 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS36


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS36

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for MRPS36 (ENSP000002564414) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    MRPL42ENSP000003515064STRING: ENSP00000351506
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation NAS11279123

    MRPS36 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRPS36 (RT36)

    Search CenterWatch for drugs/clinical trials and news about MRPS36 / RT36

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRPS36 gene: 
    NM_033281.5  

    Unigene Cluster for MRPS36:

    Mitochondrial ribosomal protein S36
    Hs.631971  [show with all ESTs]
    Unigene Representative Sequence: BM807595
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256441(uc003jvq.3) ENST00000507022 ENST00000512880 ENST00000602380
    ENST00000503793
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRPS36
    7 QIAGEN miScript miRNA Assays for microRNAs that regulate MRPS36:
    hsa-miR-142-5p hsa-miR-100* hsa-miR-3140-3p hsa-miR-513a-3p hsa-miR-218 hsa-miR-636 hsa-miR-548l
    SwitchGear 3'UTR luciferase reporter plasmidMRPS36 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for MRPS36
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPS36
    Clone
    Products:
         
    OriGene clones in human, mouse for MRPS36 (see all 8)
    OriGene ORF clones in mouse, rat for MRPS36
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    GenScript: all cDNA clones in your preferred vector: MRPS36 (NM_033281)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRPS36
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS36
    Sirion Biotech Customized lentivirus for stable overexpression of MRPS36 
                         Customized lentivirus expression plasmids for stable overexpression of MRPS36 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MRPS36
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPS36
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS36
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS36

    Additional mRNA sequence: 

    AF086034.1 BC015966.1 BC017900.1 

    8 DOTS entries:

    DT.413236  DT.95272616  DT.95142495  DT.95272621  DT.120928938  DT.95272620  DT.120847974  DT.91671888 

    24/118 AceView cDNA sequences (see all 118):

    AI873126 N89606 AI826702 CA441774 BQ771610 AF086034 BQ100962 BP339493 
    H88798 CR600283 CB269394 AA878659 AI271778 AA281009 CR609840 BG573870 
    BQ100685 W16974 BF438566 BM669835 BC017900 BX951861 AI271655 BM699173 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS36    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
    SP1:              -                           
    SP2:                                          


    ECgene alternative splicing isoforms for MRPS36

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRPS36 expression in normal human tissues (normalized intensities)      MRPS36 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MRPS36 Expression
    About this image


    MRPS36 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Adipose (Muscoskeletal System)
             Thoracic Perivascular Adipose

    See MRPS36 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRPS36

    SOURCE GeneReport for Unigene cluster: Hs.631971
        SABiosciences Custom PCR Arrays for MRPS36
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS36
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS36

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for MRPS36 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrps361 , 5 mitochondrial ribosomal protein S361, 5 85.62(n)1
    84.31(a)1
      13 (53.23 cM)5
    661281  NM_025369.31  NP_079645.11 
     1007359555 
    chicken
    (Gallus gallus)
    Aves MRPS361 mitochondrial ribosomal protein S36 70.3(n)
    60.4(a)
      771273  XM_001234564.2  XP_001234565.2 
    lizard
    (Anolis carolinensis)
    Reptilia MRPS366
    Uncharacterized protein
    75(a)
    1 ↔ 1
    2(12399392-12400359)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.168222 Xenopus laevis transcribed sequence with weak similarity more 87.89(n)    AW634413.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-190g11.71 si:dkey-190g11.7 57.1(n)
    51.49(a)
      567309  NM_001113608.1  NP_001107080.1 


    ENSEMBL Gene Tree for MRPS36 (if available)
    TreeFam Gene Tree for MRPS36 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRPS36 gene

    MRPS36 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for MRPS36 (see all 6)
    PGOHUM00000242893 PGOHUM00000239425 PGOHUM00000247447 PGOHUM00000237526 PGOHUM00000246158


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/293 SNPs in MRPS36 are shown (see all 293)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs68639891,2
    C--68511662(+) tctctA/Cctaaa 1 -- us2k10--------
    rs1845364221,2
    --68511877(+) GTGGTA/GTACAC 1 -- us2k10--------
    rs798533191,2
    --68511909(+) CTTAAG/AAAAGA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1129863801,2
    C--68511909(+) TTAAAAAAG/-  
            
    AAAAG
    1 -- us2k11Minor allele frequency- -:0.00CSA 2
    rs606701621,2
    C--68511912(+) AGAAAGAAA/-  
            
    TTCTG
    1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1512503351,2
    --68512061(+) GATAGG/TTGTCA 1 -- us2k10--------
    rs1902179631,2
    --68512078(+) GAGGGA/TAGGAG 1 -- us2k10--------
    rs1178891651,2
    C,F--68512141(+) AACAAT/CGTGAA 1 -- us2k11Minor allele frequency- C:0.05EA 120
    rs595265921,2
    C--68512177(+) TGAAA-/ATAATT 1 -- us2k10--------
    rs1404277541,2
    --68512213(+) CTCACA/GCCTGT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for MRPS36 (68513573 - 68525985 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MRPS36:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509066CNV Insertion20534489

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MRPS36
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPS36

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MRPS36 for disorders           About MalaCards
    OMIM gene information: 611996    OMIM disorders: --


    MRPS36 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRPS36
    Human Genome Epidemiology (HuGE) Navigator: MRPS36 (1 document)

    Export disorders for MRPS36 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRPS36 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with MRPS36)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2, 3 Koc E.C.... Spremulli L.L. (2001)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92259 HGNC: 16631 AceView: MRPS36 Ensembl:ENSG00000134056 euGenes: HUgn92259
    ECgene: MRPS36 H-InvDB: MRPS36

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRPS36 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRPS36 gene:
    Search GeneIP for patents involving MRPS36

    GeneCards and IP:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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