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Aliases for MRPS36 Gene

Aliases for MRPS36 Gene

  • Mitochondrial Ribosomal Protein S36 2 3 5
  • MRP-S36 3 4
  • S36mt 3 4
  • 28S Ribosomal Protein S36, Mitochondrial 3
  • DC47 3

External Ids for MRPS36 Gene

Previous GeneCards Identifiers for MRPS36 Gene

  • GC05P068665
  • GC05P070079
  • GC05P068485
  • GC05P068529
  • GC05P068549
  • GC05P068514
  • GC05P065470
  • GC05P068515

Summaries for MRPS36 Gene

Entrez Gene Summary for MRPS36 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. The mitochondrial ribosome (mitoribosome) consists of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 3p, 4q, 8p, 11q, 12q, and 20p. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS36 Gene

MRPS36 (Mitochondrial Ribosomal Protein S36) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS36 Gene

Genomics for MRPS36 Gene

Regulatory Elements for MRPS36 Gene

Enhancers for MRPS36 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F069216 0.5 ENCODE 17.4 +0.5 461 2.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 CCDC125 MRPS36 SMN2 CDK7 MARVELD2
GH05F069078 0.2 ENCODE 4 -138.4 -138419 1.5 HLF ZNF133 CEBPB RAD21 ARID1B JUND ATF3 CEBPA HMBOX1 HNF4G LOC105379014 MRPS36 LOC100130639 GC05M069084
GH05F069213 0.4 ENCODE 0.8 -3.8 -3798 0.2 ELF3 CBX3 ARID4B ZNF366 FOS CREM JUNB CEBPB TGIF2 SMARCA4 CDK7 CENPH CCNB1 ENSG00000220986 MRPS36 PIR48224
GH05F069225 0.2 ENCODE 0.4 +8.3 8318 1.1 SOX13 SOX5 TFE3 SAP130 ARID4B CEBPG HNF1A ZKSCAN8 CEBPA TCF7 CCDC125 CDK7 CENPH CCNB1 ENSG00000220986 ENSG00000248664 OCLN MRPS36
GH05F069206 0.2 ENCODE 0.4 -11.0 -10958 0.2 SAP130 THRB RARA HIC1 ZFHX2 ZNF366 FOS KLF8 HOMEZ GATAD2A CCNB1 ENSG00000220986 CDK7 MRPS36 PIR48224
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MRPS36 on UCSC Golden Path with GeneCards custom track

Promoters for MRPS36 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000037679 354 2201 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for MRPS36 Gene

Chromosome:
5
Start:
69,217,746 bp from pter
End:
69,230,158 bp from pter
Size:
12,413 bases
Orientation:
Plus strand

Genomic View for MRPS36 Gene

Genes around MRPS36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS36 Gene

Proteins for MRPS36 Gene

  • Protein details for MRPS36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82909-RT36_HUMAN
    Recommended name:
    28S ribosomal protein S36, mitochondrial
    Protein Accession:
    P82909
    Secondary Accessions:
    • Q9H2H4

    Protein attributes for MRPS36 Gene

    Size:
    103 amino acids
    Molecular mass:
    11466 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

neXtProt entry for MRPS36 Gene

Post-translational modifications for MRPS36 Gene

  • Ubiquitination at Lys 33 and Lys 78
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS36 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS36 Gene

Domains & Families for MRPS36 Gene

Gene Families for MRPS36 Gene

Protein Domains for MRPS36 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for MRPS36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPS36: view

No data available for UniProtKB/Swiss-Prot for MRPS36 Gene

Function for MRPS36 Gene

Gene Ontology (GO) - Molecular Function for MRPS36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
GO:0004591 contributes_to oxoglutarate dehydrogenase (succinyl-transferring) activity IBA --
genes like me logo Genes that share ontologies with MRPS36: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRPS36 Gene

Localization for MRPS36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS36 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS36 Gene COMPARTMENTS Subcellular localization image for MRPS36 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPS36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion ISS,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IDA 11279123
GO:0005840 ribosome IEA --
GO:0009353 mitochondrial oxoglutarate dehydrogenase complex IBA --
genes like me logo Genes that share ontologies with MRPS36: view

Pathways & Interactions for MRPS36 Gene

genes like me logo Genes that share pathways with MRPS36: view

Interacting Proteins for MRPS36 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000256441%0d%0a9606.ENSP00000472998%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000447547%0d%0a9606.ENSP00000421307%0d%0a
Selected Interacting proteins: P82909-RT36_HUMAN ENSP00000256441 for MRPS36 Gene via IID STRING

Gene Ontology (GO) - Biological Process for MRPS36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006103 2-oxoglutarate metabolic process IBA --
GO:0006412 translation NAS 11279123
GO:0055114 oxidation-reduction process IEA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS36: view

No data available for SIGNOR curated interactions for MRPS36 Gene

Transcripts for MRPS36 Gene

Unigene Clusters for MRPS36 Gene

Mitochondrial ribosomal protein S36:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS36 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b
SP1: -
SP2:

Relevant External Links for MRPS36 Gene

GeneLoc Exon Structure for
MRPS36
ECgene alternative splicing isoforms for
MRPS36

Expression for MRPS36 Gene

mRNA expression in normal human tissues for MRPS36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS36 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.0) and Frontal cortex (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MRPS36 Gene



Protein tissue co-expression partners for MRPS36 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS36 Gene:

MRPS36

SOURCE GeneReport for Unigene cluster for MRPS36 Gene:

Hs.631971
genes like me logo Genes that share expression patterns with MRPS36: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS36 Gene

Orthologs for MRPS36 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPS36 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS36 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia MRPS36 34 35
  • 92.56 (n)
cow
(Bos Taurus)
Mammalia MRPS36 34 35
  • 90.94 (n)
mouse
(Mus musculus)
Mammalia Mrps36 34 16 35
  • 85.62 (n)
Mrps36-ps1 35
  • 83 (a)
OneToMany
Gm7258 35
  • 77 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mrps36 34
  • 83.82 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPS36 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS36 34 35
  • 70.96 (n)
lizard
(Anolis carolinensis)
Reptilia MRPS36 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps36 34
  • 67 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16822 34
zebrafish
(Danio rerio)
Actinopterygii si:dkey-190g11.7 34
  • 57.43 (n)
MRPS36 35
  • 42 (a)
OneToOne
Species where no ortholog for MRPS36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS36 Gene

ENSEMBL:
Gene Tree for MRPS36 (if available)
TreeFam:
Gene Tree for MRPS36 (if available)

Paralogs for MRPS36 Gene

genes like me logo Genes that share paralogs with MRPS36: view

No data available for Paralogs for MRPS36 Gene

Variants for MRPS36 Gene

Sequence variations from dbSNP and Humsavar for MRPS36 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs112986380 -- 69,216,082(+) TTAAA(-/AAAG)AAAAG upstream-variant-2KB
rs117889165 -- 69,216,314(+) AACAA(C/T)GTGAA upstream-variant-2KB
rs13158531 -- 69,216,406(+) actta(A/G)ggagg upstream-variant-2KB
rs13160868 -- 69,229,022(+) ATCTC(A/C)AAAAA intron-variant
rs140427754 -- 69,216,386(+) CTCAC(A/G)CCTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRPS36 Gene

Variant ID Type Subtype PubMed ID
dgv5694n100 CNV gain 25217958
esv3605379 CNV loss 21293372
nsv509066 CNV insertion 20534489

Variation tolerance for MRPS36 Gene

Residual Variation Intolerance Score: 45.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.42; 27.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS36 Gene

Disorders for MRPS36 Gene

Relevant External Links for MRPS36

Genetic Association Database (GAD)
MRPS36
Human Genome Epidemiology (HuGE) Navigator
MRPS36
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS36

No disorders were found for MRPS36 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS36 Gene

Publications for MRPS36 Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for MRPS36 Gene

Sources for MRPS36 Gene

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