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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRPS35 Gene

protein-coding   GIFtS: 50
GCID: GC12P027863

Mitochondrial Ribosomal Protein S35

  Search for MRPS35
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrial Ribosomal Protein S351 2     S28mt2 3
MRPS282 3 5     S35mt2 3
28S Ribosomal Protein S28, Mitochondrial2 3     28S Ribosomal Protein S35, Mitochondrial2
MRP-S282 3     MDS0232
MRP-S352 3     Mitochondrial Ribosomal Protein S282

External Ids:    HGNC: 166351   Entrez Gene: 604882   Ensembl: ENSG000000617947   OMIM: 6119955   UniProtKB: P826733   

Export aliases for MRPS35 gene to outside databases

Previous GC identifers: GC12P028236 GC12P027887 GC12P027763 GC12P027754 GC12P027632


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRPS35 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript
variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are
found on chromosomes 3p, 5q, and 10q. (provided by RefSeq, Jul 2010)

GeneCards Summary for MRPS35 Gene: 
MRPS35 (mitochondrial ribosomal protein S35) is a protein-coding gene.

Gene Wiki entry for MRPS35 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRPS35 gene promoter:
         CREB   Sox5   POU2F1   Brachyury   POU2F1a   FOXD3   ZIC2/Zic2   Nkx2-5   POU3F2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPS35 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRPS35

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11   Ensembl cytogenetic band:  12p11.22   HGNC cytogenetic band: 12p11

MRPS35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPS35 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P027863:  view genomic region     (about GC identifiers)

Start:
27,863,706 bp from pter      End:
27,909,237 bp from pter
Size:
45,532 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RT35_HUMAN, P82673 (See protein sequence)
Recommended Name: 28S ribosomal protein S35, mitochondrial precursor  
Size: 323 amino acids; 36844 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30
distinct proteins (By similarity)
Subcellular location: Mitochondrion (By similarity)
Sequence caution: Sequence=AAG14958.1; Type=Frameshift; Positions=97; Sequence=BAC11579.1; Type=Frameshift;
Positions=176;
Secondary accessions: Q32LZ1 Q6P4C6 Q7L1M6 Q8NBP4 Q96AI0 Q9H044 Q9HC14 Q9P1R5
Alternative splicing: 2 isoforms:  P82673-1   P82673-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MRPS35: NX_P82673

Explore proteomics data for MRPS35 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P82673

  • MRPS35 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MRPS35 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_068593.2  NP_001177793.1  

    ENSEMBL proteins: 
     ENSP00000081029   ENSP00000437990   ENSP00000445390   ENSP00000437991   ENSP00000442137  

    Human Recombinant Protein Products for MRPS35: 
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    Cloud-Clone Corp. Proteins for MRPS35 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005763mitochondrial small ribosomal subunit NAS11279123

    MRPS35 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MRPS: Mitochondrial ribosomal proteins / small subunits

    1 InterPro protein domain:
     IPR019349 Ribosomal_S24/S35_mit

    Graphical View of Domain Structure for InterPro Entry P82673

    ProtoNet protein and cluster: P82673


    MRPS35 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         2 GenomeRNAi human phenotypes for MRPS35:
     Increased G2M DNA content  Increased homologous recombina 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Mrps35):
     behavior/neurological  integument 

    MRPS35 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MRPS35 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS35

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/251 Interacting proteins for MRPS35 (P826732, 3 ENSP000000810294) via UniProtKB, MINT, STRING, and/or I2D (see all 251)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    USP42Q9H9J43, ENSP000003019624I2D: score=2 STRING: ENSP00000301962
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    B9D1Q9UPM93I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0042769DNA damage response, detection of DNA damage NAS15300802
    GO:0043043peptide biosynthetic process IC11279123

    MRPS35 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRPS35 (RT35)

    Search CenterWatch for drugs/clinical trials and news about MRPS35 / RT35

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRPS35 gene (2 alternative transcripts): 
    NM_021821.3  NM_001190864.1  

    Unigene Cluster for MRPS35:

    Mitochondrial ribosomal protein S35
    Hs.714076  [show with all ESTs]
    Unigene Representative Sequence: BC028346
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000081029(uc001rih.3 uc001rii.3) ENST00000536569 ENST00000538315
    ENST00000542791 ENST00000542199
    miRNA
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    4 QIAGEN miScript miRNA Assays for microRNAs that regulate MRPS35:
    hsa-miR-3163 hsa-miR-3143 hsa-miR-3074-3p hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidMRPS35 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS35

    Additional mRNA sequence: 

    AF068296.1 AF182422.1 AK075378.1 AK075515.1 AL512733.1 BC015862.1 BC017086.1 BC028346.2 
    BC063515.1 BC109372.1 

    10 DOTS entries:

    DT.80101314  DT.99929401  DT.121207716  DT.95136024  DT.121207694  DT.95136021  DT.100811056  DT.101974024 
    DT.121207717  DT.95136019 

    24/301 AceView cDNA sequences (see all 301):

    BQ425222 CD673972 BM741906 CA413401 BX339576 BM852363 BU688922 BF939502 
    BM828518 AA370976 BM662169 AI245992 BC015862 AL512733 BM840356 AA302815 
    BU782873 CR595120 AA582908 CD742941 AI039606 CA307993 CR612857 BX423610 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS35    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                                  
    SP2:                                            -                     
    SP3:                    -     -     -     -     -     -               


    ECgene alternative splicing isoforms for MRPS35

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRPS35 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGCTGTCT
    MRPS35 Expression
    About this image


    See MRPS35 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRPS35

    SOURCE GeneReport for Unigene cluster: Hs.714076
        SABiosciences Custom PCR Arrays for MRPS35
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS35

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MRPS35 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrps351 , 5 mitochondrial ribosomal protein S351, 5 76.59(n)1
    76.8(a)1
      6 (77.70 cM)5
    2325361  NM_145573.21  NP_663548.21 
     1470427645 
    chicken
    (Gallus gallus)
    Aves MRPS351 mitochondrial ribosomal protein S35 69.05(n)
    67.86(a)
      419048  XM_417239.3  XP_417239.2 
    lizard
    (Anolis carolinensis)
    Reptilia MRPS356
    --
    --
    70(a)
    60(a)
    1 ↔ 1
    possible ortholog
    5(82934016-82939677)
    GL343579.1(103246-114777)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.63032 Xenopus laevis transcribed sequence with weak similarity more 70.75(n)    BX851679.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.103872 Transcribed sequence with weak similarity to protein more 74.06(n)    57091436 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpS283
    mRpS351
    protein biosynthesis structural
    constituent of more3
    mitochondrial ribosomal protein S351
    47(a)3
    52.44(n)1
    49.62(a)1
      62F43
    383451  NM_079169.21  NP_523893.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y39B6A.393
    mrps-351
    Protein MRPS-351 39(a)3
    50.68(n)1
    40.96(a)1
      V(18977998-18982294)3
    1802401  NM_171568.31  NP_741658.11 


    ENSEMBL Gene Tree for MRPS35 (if available)
    TreeFam Gene Tree for MRPS35 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRPS35 gene

    MRPS35 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MRPS35
    PGOHUM00000238808 PGOHUM00000235324


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/900 SNPs in MRPS35 are shown (see all 900)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs761174341,2
    F--27861756(+) GGGCAG/AAAGGT 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1818314271,2
    --27861804(+) GCAACC/TATTAG 2 -- us2k10--------
    rs767388751,2
    F--27861927(+) TTTCTG/ATTGTT 2 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1451281731,2
    --27861950(+) GTTTAC/GGGTAC 2 -- us2k10--------
    rs1438940191,2
    --27861985(+) CATACA/GTCATG 2 -- us2k10--------
    rs110491031,2
    C,F,A,H--27862081(+) TATTTG/ATCCCC 2 -- us2k119Minor allele frequency- A:0.17NS EA NA WA 2344
    rs1904591791,2
    --27862117(+) CATGGC/TGCACT 2 -- us2k10--------
    rs1466925451,2
    --27862118(+) ATGGCA/GCACTG 2 -- us2k10--------
    rs1836627601,2
    --27862119(+) TGGCGC/TACTGA 2 -- us2k10--------
    rs1869418121,2
    --27862149(+) TCTTGC/GACACC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MRPS35 (27863706 - 27909237 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for MRPS35:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2674076CNV Deletion23128226
    esv2745671CNV Deletion23290073
    esv2745664CNV Deletion23290073
    esv270584CNV Insertion20981092
    esv272743CNV Insertion20981092
    nsv469178CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MRPS35
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MRPS35 for disorders           About MalaCards
    OMIM gene information: 611995    OMIM disorders: --


    MRPS35 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRPS35
    Human Genome Epidemiology (HuGE) Navigator: MRPS35 (1 document)

    Export disorders for MRPS35 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRPS35 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with MRPS35)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach. (PubMed id 11344316)1, 2 Koc E.C....Spremulli L.L. (2001)
    5. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 3 Koc E.C.... Spremulli L.L. (2001)
    6. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 60488 HGNC: 16635 AceView: MRPS35 Ensembl:ENSG00000061794 euGenes: HUgn60488
    ECgene: MRPS35 H-InvDB: MRPS35

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRPS35 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRPS35 gene:
    Search GeneIP for patents involving MRPS35

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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