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Aliases for MRPS35 Gene

Aliases for MRPS35 Gene

  • Mitochondrial Ribosomal Protein S35 2 3
  • MRPS28 3 4 6
  • 28S Ribosomal Protein S28, Mitochondrial 3 4
  • MRP-S28 3 4
  • MRP-S35 3 4
  • S28mt 3 4
  • S35mt 3 4
  • 28S Ribosomal Protein S35, Mitochondrial 3
  • Mitochondrial Ribosomal Protein S28 3
  • HDCMD11P 3
  • MDS023 3

External Ids for MRPS35 Gene

Summaries for MRPS35 Gene

Entrez Gene Summary for MRPS35 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and 10q. [provided by RefSeq, Jul 2010]

GeneCards Summary for MRPS35 Gene

MRPS35 (Mitochondrial Ribosomal Protein S35) is a Protein Coding gene.

Gene Wiki entry for MRPS35 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS35 Gene

Genomics for MRPS35 Gene

Genomic Location for MRPS35 Gene

Start:
27,710,773 bp from pter
End:
27,756,304 bp from pter
Size:
45,532 bases
Orientation:
Plus strand

Genomic View for MRPS35 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS35 Gene

Regulatory Elements for MRPS35 Gene

Proteins for MRPS35 Gene

  • Protein details for MRPS35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82673-RT35_HUMAN
    Recommended name:
    28S ribosomal protein S35, mitochondrial
    Protein Accession:
    P82673
    Secondary Accessions:
    • Q32LZ1
    • Q6P4C6
    • Q7L1M6
    • Q8NBP4
    • Q96AI0
    • Q9H044
    • Q9HC14
    • Q9P1R5

    Protein attributes for MRPS35 Gene

    Size:
    323 amino acids
    Molecular mass:
    36844 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
    SequenceCaution:
    • Sequence=AAG14958.1; Type=Frameshift; Positions=97; Evidence={ECO:0000305};

    Alternative splice isoforms for MRPS35 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPS35 Gene

Proteomics data for MRPS35 Gene at MOPED

Post-translational modifications for MRPS35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS35 Gene

No data available for DME Specific Peptides for MRPS35 Gene

Domains for MRPS35 Gene

Gene Families for MRPS35 Gene

HGNC:
  • MRPS :Mitochondrial ribosomal proteins / small subunits

Protein Domains for MRPS35 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with MRPS35: view

No data available for UniProtKB/Swiss-Prot for MRPS35 Gene

Function for MRPS35 Gene

Gene Ontology (GO) - Molecular Function for MRPS35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MRPS35: view

Phenotypes for MRPS35 Gene

genes like me logo Genes that share phenotypes with MRPS35: view

miRNA for MRPS35 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPS35 Gene

Localization for MRPS35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS35 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS35 Gene COMPARTMENTS Subcellular localization image for MRPS35 gene
Compartment Confidence
mitochondrion 4
cytosol 1
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MRPS35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit NAS 11279123
genes like me logo Genes that share ontologies with MRPS35: view

Pathways for MRPS35 Gene

SuperPathways for MRPS35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRPS35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0042769 DNA damage response, detection of DNA damage NAS 15300802
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPS35: view

No data available for Pathways by source for MRPS35 Gene

Transcripts for MRPS35 Gene

Unigene Clusters for MRPS35 Gene

Mitochondrial ribosomal protein S35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS35 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1:
SP2: -
SP3: - - - - - -

Relevant External Links for MRPS35 Gene

GeneLoc Exon Structure for
MRPS35
ECgene alternative splicing isoforms for
MRPS35

Expression for MRPS35 Gene

mRNA expression in normal human tissues for MRPS35 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS35 Gene

SOURCE GeneReport for Unigene cluster for MRPS35 Gene Hs.714076

genes like me logo Genes that share expressions with MRPS35: view

Orthologs for MRPS35 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS35 36
  • 98.04 (n)
  • 97.5 (a)
MRPS35 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPS35 36
  • 86.85 (n)
  • 84.16 (a)
MRPS35 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS35 36
  • 87.06 (n)
  • 85.09 (a)
MRPS35 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrps35 36
  • 76.59 (n)
  • 76.8 (a)
Mrps35 16
Mrps35 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPS35 37
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS35 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps35 36
  • 77.12 (n)
  • 78.37 (a)
chicken
(Gallus gallus)
Aves MRPS35 36
  • 69.05 (n)
  • 67.86 (a)
MRPS35 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 70 (a)
OneToMany
-- 37
  • 60 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.6303 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps35 36
  • 63.21 (n)
  • 65.93 (a)
Str.11071 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5353 36
zebrafish
(Danio rerio)
Actinopterygii Dr.10387 36
mrps35 36
  • 61.65 (n)
  • 63.55 (a)
mrps35 37
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006802 36
  • 51.23 (n)
  • 52.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS35 36
  • 52.95 (n)
  • 50.38 (a)
mRpS35 37
  • 41 (a)
OneToOne
mRpS28 38
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea mrps-35 36
  • 51.19 (n)
  • 41.95 (a)
mrps-35 37
  • 30 (a)
OneToOne
Y39B6A.39 38
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
OneToOne
Species with no ortholog for MRPS35:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS35 Gene

ENSEMBL:
Gene Tree for MRPS35 (if available)
TreeFam:
Gene Tree for MRPS35 (if available)

Paralogs for MRPS35 Gene

Pseudogenes.org Pseudogenes for MRPS35 Gene

genes like me logo Genes that share paralogs with MRPS35: view

No data available for Paralogs for MRPS35 Gene

Variants for MRPS35 Gene

Sequence variations from dbSNP and Humsavar for MRPS35 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs720878 -- 27,753,353(-) ACACC(A/G)AGTCA intron-variant
rs1035684 -- 27,721,913(+) gagat(A/C)atgtc intron-variant
rs1127787 -- 27,714,794(+) CACCC(A/G)GAAAT missense, reference
rs1863222 -- 27,729,305(+) GGACA(A/G)TGGTG intron-variant
rs2346760 -- 27,719,121(+) CACGT(C/G)CTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS35 Gene

Variant ID Type Subtype PubMed ID
esv2745664 CNV Deletion 23290073
nsv469178 CNV Gain 19166990
esv270584 CNV Insertion 20981092
esv272743 CNV Insertion 20981092
esv2674076 CNV Deletion 23128226
esv2745671 CNV Deletion 23290073

Relevant External Links for MRPS35 Gene

HapMap Linkage Disequilibrium report
MRPS35

Disorders for MRPS35 Gene

Relevant External Links for MRPS35

Genetic Association Database (GAD)
MRPS35
Human Genome Epidemiology (HuGE) Navigator
MRPS35
genes like me logo Genes that share disorders with MRPS35: view

No data available for UniProtKB/Swiss-Prot for MRPS35 Gene

Publications for MRPS35 Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3
  2. Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach. (PMID: 11344316) Koc E.C. … Spremulli L.L. (Protein Sci. 2001) 3 4
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MRPS35 Gene

  • antibodies-online proteins for MRPS35
  • antibodies-online antibodies for MRPS35
  • antibodies-online kits for MRPS35

Sources for MRPS35 Gene

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