MRPS35 Gene
protein-coding GIFtS: 48
GCID: GC12P027863
|
|
mitochondrial ribosomal protein S35
| |
Aliases
for MRPS35 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein S351 2 | | MRP-S352 3 | | MRPS281 2 3 5 | | S28mt2 3 | | MDS0231 2 | | S35mt2 3 | | 28S Ribosomal Protein S28, Mitochondrial2 3 | | 28S Ribosomal Protein S35, Mitochondrial2 | | MRP-S282 3 | | Mitochondrial Ribosomal Protein S282 |
Export aliases for MRPS35 gene to outside databasesPrevious GC identifers: GC12P028236 GC12P027887 GC12P027763 GC12P027754 GC12P027632 |
Summaries
for MRPS35 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPS35:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit proteinthat has had confusing nomenclature in the literature. Alternatively spliced transcript variants encoding differentisoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 3p, 5q, and10q. (provided by RefSeq, Jul 2010)
Gene Wiki entry for MRPS35
|
Genomic Views
for MRPS35 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009714.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPS35 gene promoter:
CREB Sox5 POU2F1 Brachyury POU2F1a FOXD3 ZIC2/Zic2 Nkx2-5 POU3F2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPS35
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS35 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p11 Ensembl cytogenetic band: 12p11.22 HGNC cytogenetic band: 12p11MRPS35 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P027863: view genomic region
(about GC identifiers)
Start:
|
27,863,706 bp from pter |
End:
|
27,909,237 bp from pter |
Size:
|
45,532 bases |
Orientation:
|
plus strand |
|
Proteins
for MRPS35 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RT35_HUMAN, P82673 (See
protein sequence)Recommended Name: 28S ribosomal protein S35, mitochondrial precursor Size: 323 amino acids; 36844 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinctproteins (By similarity)
Subcellular location: Mitochondrion (By similarity)
Sequence caution: Sequence=AAG14958.1; Type=Frameshift; Positions=97; Sequence=BAC11579.1; Type=Frameshift;Positions=176;
Secondary accessions: Q32LZ1 Q6P4C6 Q7L1M6 Q8NBP4 Q96AI0 Q9H044 Q9HC14 Q9P1R5Alternative splicing: 2 isoforms: P82673-1 P82673-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MRPS35: NX_P82673
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P82673
MRPS35 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_068593.2 NP_001177793.1
ENSEMBL proteins: ENSP00000081029 ENSP00000437990 ENSP00000445390 ENSP00000437991 ENSP00000442137
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MRPS35 for ontologies About GeneDecksing
MRPS35 Antibody Products:
Assay Products for MRPS35: |
Protein
Domains /
Families
for MRPS35 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPS35 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P82673ProtoNet protein and cluster: P82673 |
Function
for MRPS35 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS35 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS35 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MRPS35 (NM_021821) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS35 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS35 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS35 |
2 GenomeRNAi human phenotypes for MRPS35:
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Mrps35):
MRPS35 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MRPS35 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS35
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/237 Interacting proteins for MRPS35 (P826732, 3 ENSP000000810294) via UniProtKB, MINT, STRING, and/or I2D (see all 237)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
MRPS35 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRPS35 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPS35
Search CenterWatch for drugs/clinical trials and news about MRPS35 / RT35
|
Transcripts
for MRPS35 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPS35 gene (2 alternative transcripts): NM_021821.3 NM_001190864.1 Unigene Cluster for MRPS35: Mitochondrial ribosomal protein S35 Hs.714076 [show with all ESTs]Unigene Representative Sequence: BC0283465 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000081029(uc001rih.3 uc001rii.3) ENST00000536569 ENST00000538315
ENST00000542791 ENST00000542199
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS35 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS35 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MRPS35 (NM_021821) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS35 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS35 |
Additional cDNA sequence: AF068296.1 AF182422.1 AK075378.1 AK075515.1 AL512733.1 BC015862.1 BC017086.1 BC028346.2 BC063515.1 BC109372.1 10 DOTS entries: DT.80101314 DT.99929401 DT.121207716 DT.95136024 DT.121207694 DT.95136021 DT.100811056 DT.101974024 DT.121207717 DT.95136019 24/301 AceView cDNA sequences (see all 301): BC015862 BQ218806 BU782873 BM852363 AK075515 T68686 AI001862 BU632850 BF823572 BG054719 AA236018 AA972524 AA302815 BP374213 BQ775165 CR612857 BC028346 AI421157 BE397202 BM840356 AI087076 AI037872 AI086665 CD673972
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS35 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | - | | - | | - | | | | | |
ECgene alternative splicing isoforms for MRPS35
|
Expression
for MRPS35 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPS35 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTGCTGTCT
About this image
See MRPS35 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPS35
SOURCE GeneReport for Unigene cluster: Hs.714076
SABiosciences Custom PCR Arrays for MRPS35
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS35
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPS35 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS35 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS35 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS35 |
Orthologs
for MRPS35 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MRPS35 gene from 7/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mrps351 , 5 |
mitochondrial ribosomal protein S351, 5 |
76.59(n)1
76.8(a)1 |
|
6 (77.70 cM)5
2325361 NM_145573.21 NP_663548.21
1470427645 |
chicken
(Gallus gallus) |
Aves |
MRPS351 |
mitochondrial ribosomal protein S35 |
69.05(n)
67.86(a) |
|
419048 XM_417239.3 XP_417239.2 |
lizard
(Anolis carolinensis) |
Reptilia |
--MRPS356 |
-- |
73(a)70(a) |
many → 1many → 1 |
GL343579.1(103883-111916) 5(82934016-82939677) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.63032 |
Xenopus laevis transcribed sequence with weak similarity more |
70.75(n) |
|
BX851679.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.103872 |
Transcribed sequence with weak similarity to protein more |
74.06(n) |
|
57091436 |
fruit fly
(Drosophila melanogaster) |
Insecta |
mRpS283
mRpS351 |
protein biosynthesis structural constituent
of more3
mitochondrial ribosomal protein S351 |
47(a)3
52.44(n)1
49.62(a)1 |
|
62F43
383451 NM_079169.21 NP_523893.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y39B6A.393
mrps-351 |
Protein MRPS-351 |
39(a)3
50.68(n)1
40.96(a)1 |
|
V(18977998-18982294)3
1802401 NM_171568.31 NP_741658.11 |
ENSEMBL Gene Tree for MRPS35 (if available)
TreeFam Gene Tree for MRPS35 (if available) |
Paralogs
for MRPS35 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRPS35 gene
MRPS35 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for MRPS35
PGOHUM00000238808 PGOHUM00000235324
|
Genomic Variants
for MRPS35 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPS35 (27863706 - 27909237 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for MRPS35
3 CNVs: 86280 86279 86281 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS35 |
|
Disorders
/ Diseases
for MRPS35 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRPS35 for disorders About MalaCards
MRPS35 for disorders About GeneDecksing
OMIM gene information: 611995
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MRPS35 (1 document)
Export disorders for MRPS35 gene to outside databases
|
Publications
for MRPS35 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPS35 gene, integrated from 9 sources (see all 21):
(articles sorted by number of sources associating them with MRPS35) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach. (PubMed id 11344316)1, 2 Koc E.C....Spremulli L.L. (2001)
- The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 3 Koc E.C.... Spremulli L.L. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
|
External Searches for MRPS35 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPS35 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPS35 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPS35 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPS35 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRPS35 gene:
Search GeneIP for patents involving MRPS35
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPS35 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS35 |
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