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Aliases for MRPS34 Gene

Aliases for MRPS34 Gene

  • Mitochondrial Ribosomal Protein S34 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein MS34 3 4
  • MRP-S34 3 4
  • S34mt 3 4
  • 28S Ribosomal Protein S34, Mitochondrial 3
  • Mitochondrial 28S Ribosomal Protein S34 3
  • MRP-S12 3
  • MRPS12 3

External Ids for MRPS34 Gene

Previous GeneCards Identifiers for MRPS34 Gene

  • GC16M001839
  • GC16M001761
  • GC16M001821

Summaries for MRPS34 Gene

Entrez Gene Summary for MRPS34 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for MRPS34 Gene

MRPS34 (Mitochondrial Ribosomal Protein S34) is a Protein Coding gene. Diseases associated with MRPS34 include Combined Oxidative Phosphorylation Deficiency 32. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance.

UniProtKB/Swiss-Prot for MRPS34 Gene

  • Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation.

Additional gene information for MRPS34 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS34 Gene

Genomics for MRPS34 Gene

Regulatory Elements for MRPS34 Gene

Enhancers for MRPS34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H001192 0.8 dbSUPER 4.9 +580.3 580292 1.4 CTCF KLF1 ATF1 ZIC2 RAD21 YY1 HIC1 MTA3 EGR1 ZNF600 NHLRC4 MRPS34 LOC102723999 GC16P001205
GH16H001530 1.2 FANTOM5 ENCODE dbSUPER 1.2 +237.9 237932 10 CTCF LEF1 TAF1 MAX MNT NR3C1 ZIC2 ZNF2 RAD21 NR2F2 TMEM204 TELO2 FAHD1 PTX4 IFT140 CCDC154 NME3 TSR3 FBXL16 CLCN7
GH16H001769 1.4 ENCODE dbSUPER 0.7 +0.6 604 6.4 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ENSG00000261505 EME2 ENSG00000260051 CRAMP1 TELO2 SRRM2 UNKL UBE2I ENSG00000260954 ENSG00000255513
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPS34 on UCSC Golden Path with GeneCards custom track

Promoters for MRPS34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000082385 755 3201 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Locations for MRPS34 Gene

Genomic Locations for MRPS34 Gene
chr16:1,771,890-1,773,155
(GRCh38/hg38)
Size:
1,266 bases
Orientation:
Minus strand
chr16:1,821,891-1,823,156
(GRCh37/hg19)

Genomic View for MRPS34 Gene

Genes around MRPS34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS34 Gene

Proteins for MRPS34 Gene

  • Protein details for MRPS34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82930-RT34_HUMAN
    Recommended name:
    28S ribosomal protein S34, mitochondrial
    Protein Accession:
    P82930
    Secondary Accessions:
    • Q9BVI7

    Protein attributes for MRPS34 Gene

    Size:
    218 amino acids
    Molecular mass:
    25650 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS34 Gene

neXtProt entry for MRPS34 Gene

Post-translational modifications for MRPS34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS34 Gene

No data available for DME Specific Peptides for MRPS34 Gene

Domains & Families for MRPS34 Gene

Gene Families for MRPS34 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for MRPS34 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPS34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P82930

UniProtKB/Swiss-Prot:

RT34_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mS34 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mS34 family.
genes like me logo Genes that share domains with MRPS34: view

Function for MRPS34 Gene

Molecular function for MRPS34 Gene

UniProtKB/Swiss-Prot Function:
Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation.

Gene Ontology (GO) - Molecular Function for MRPS34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
genes like me logo Genes that share ontologies with MRPS34: view
genes like me logo Genes that share phenotypes with MRPS34: view

Animal Model Products

miRNA for MRPS34 Gene

miRTarBase miRNAs that target MRPS34

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS34 Gene

Localization for MRPS34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS34 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS34 gene
Compartment Confidence
mitochondrion 5
peroxisome 2
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPS34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MRPS34: view

Pathways & Interactions for MRPS34 Gene

genes like me logo Genes that share pathways with MRPS34: view

Gene Ontology (GO) - Biological Process for MRPS34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032543 mitochondrial translation ISS --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS34: view

No data available for SIGNOR curated interactions for MRPS34 Gene

Drugs & Compounds for MRPS34 Gene

No Compound Related Data Available

Transcripts for MRPS34 Gene

mRNA/cDNA for MRPS34 Gene

Unigene Clusters for MRPS34 Gene

Mitochondrial ribosomal protein S34:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS34 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e
SP1: - -
SP2: -
SP3: -
SP4: -

Relevant External Links for MRPS34 Gene

GeneLoc Exon Structure for
MRPS34
ECgene alternative splicing isoforms for
MRPS34

Expression for MRPS34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS34 Gene

This gene is overexpressed in Nasal epithelium (35.3) and Breast (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS34 Gene



Protein tissue co-expression partners for MRPS34 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS34 Gene:

MRPS34

SOURCE GeneReport for Unigene cluster for MRPS34 Gene:

Hs.720388

Evidence on tissue expression from TISSUES for MRPS34 Gene

  • Eye(4.3)
  • Nervous system(2.3)
  • Muscle(2.2)
  • Lung(2.1)
genes like me logo Genes that share expression patterns with MRPS34: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS34 Gene

Orthologs for MRPS34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPS34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS34 33 34
  • 99.54 (n)
cow
(Bos Taurus)
Mammalia MRPS34 34 33
  • 84.1 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mrps34 16 34 33
  • 83.18 (n)
rat
(Rattus norvegicus)
Mammalia Mrps34 33
  • 82.57 (n)
dog
(Canis familiaris)
Mammalia MRPS34 33 34
  • 79.53 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPS34 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS34 33 34
  • 71.13 (n)
lizard
(Anolis carolinensis)
Reptilia MRPS34 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps34 33
  • 61.84 (n)
Str.8211 33
African clawed frog
(Xenopus laevis)
Amphibia mrps34-prov 33
zebrafish
(Danio rerio)
Actinopterygii mrps34 33 34
  • 62.02 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2892 34
  • 31 (a)
OneToOne
Species where no ortholog for MRPS34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS34 Gene

ENSEMBL:
Gene Tree for MRPS34 (if available)
TreeFam:
Gene Tree for MRPS34 (if available)

Paralogs for MRPS34 Gene

No data available for Paralogs for MRPS34 Gene

Variants for MRPS34 Gene

Sequence variations from dbSNP and Humsavar for MRPS34 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000988298 -- 1,773,005(+) GGTCT(C/T)GTAGT upstream-variant-2KB, reference, missense
rs1002180875 -- 1,771,576(+) GGTGG(C/T)GCCCG intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs1003213252 -- 1,772,269(+) GCAGG(A/G)TAATC upstream-variant-2KB, reference, synonymous-codon
rs1003222824 -- 1,774,798(+) ACCAG(A/G)ATGAG intron-variant, upstream-variant-2KB
rs1003252289 -- 1,774,929(+) CGGCA(A/C)CACTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRPS34 Gene

Variant ID Type Subtype PubMed ID
nsv952900 CNV deletion 24416366
nsv827500 CNV gain 20364138
nsv571173 CNV loss 21841781
nsv571172 CNV loss 21841781
nsv571171 CNV gain+loss 21841781
nsv571170 CNV loss 21841781
nsv571169 CNV loss 21841781
nsv518641 CNV loss 19592680
nsv517196 CNV gain+loss 19592680
nsv471069 CNV loss 18288195
nsv457336 CNV loss 19166990
nsv457335 CNV loss 19166990
nsv1160328 CNV deletion 26073780
nsv1051692 CNV loss 25217958
esv3892756 CNV loss 25118596
esv2422427 CNV duplication 17116639
dgv4856n54 CNV loss 21841781

Variation tolerance for MRPS34 Gene

Residual Variation Intolerance Score: 48.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.35; 97.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS34 Gene

Disorders for MRPS34 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MRPS34 Gene - From: OMIM

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MRPS34

Genetic Association Database (GAD)
MRPS34
Human Genome Epidemiology (HuGE) Navigator
MRPS34
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS34
genes like me logo Genes that share disorders with MRPS34: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MRPS34 Gene

Publications for MRPS34 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Binding of the human homolog of the Drosophila discs large tumor suppressor protein to the mitochondrial ribosomal protein MRP-S34. (PMID: 12507520) Ogawa F … Akiyama T (Biochemical and biophysical research communications 2003) 3 22 60
  4. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for MRPS34 Gene

Sources for MRPS34 Gene

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