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MRPS34 Gene

protein-coding   GIFtS: 45
GCID: GC16M001821

Mitochondrial Ribosomal Protein S34

  Search for MRPS34
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Ribosomal Protein S341 2
MRP-S342 3
S34mt2 3
MRPS122 5
28S Ribosomal Protein S34, Mitochondrial2
MRP-S122

External Ids:    HGNC: 166181   Entrez Gene: 659932   Ensembl: ENSG000000740717   OMIM: 6119945   UniProtKB: P829303   

Export aliases for MRPS34 gene to outside databases

Previous GC identifers: GC16M001839 GC16M001761


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRPS34 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
28S subunit protein. Alternate splice variants of this gene have been described but their full-length nature has
not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPS34 Gene:
MRPS34 (mitochondrial ribosomal protein S34) is a protein-coding gene.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MRPS34 gene promoter:
         USF1   Tal-1   Pax-5   Olf-1   YY1   E47   Roaz   CP2   USF-1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPS34 promoter sequence
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRPS34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

MRPS34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPS34 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M001821:  view genomic region     (about GC identifiers)

Start:
1,821,891 bp from pter      End:
1,823,156 bp from pter
Size:
1,266 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: RT34_HUMAN, P82930 (See protein sequence)
Recommended Name: 28S ribosomal protein S34, mitochondrial  
Size: 218 amino acids; 25650 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30
distinct proteins
Secondary accessions: Q9BVI7

Explore the universe of human proteins at neXtProt for MRPS34: NX_P82930

Explore proteomics data for MRPS34 at MOPED


See MRPS34 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_076425.1  
ENSEMBL proteins: 
 ENSP00000177742   ENSP00000380531  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
MRPS: Mitochondrial ribosomal proteins / small subunits

ProtoNet protein and cluster: P82930


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for MRPS34:
 Increased cell number in G2M,  

Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
RT34_HUMAN, P82930: Mitochondrion
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
mitochondrion5
peroxisome2
cytosol1
nucleus1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IDA--
GO:0005840ribosome IEA--

MRPS34 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRPS34
Interactions:

    GeneGlobe Interaction Network for MRPS34

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

Selected Interacting proteins for MRPS34 (P829302, 3 ENSP000003805314) via UniProtKB, MINT, STRING, and/or I2D (see all 259)
InteractantInteraction Details
GeneCardExternal ID(s)
NFKBIL1Q9UBC13, ENSP000003653184I2D: score=2 STRING: ENSP00000365318
ENSG00000206440Q9UBC13, ENSP000003831424I2D: score=2 STRING: ENSP00000383142
ENSG00000227565Q9UBC13I2D: score=2 
ENSG00000234530Q9UBC13I2D: score=2 
ENSG00000235125Q9UBC13I2D: score=2 
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for MRPS34 (RT34)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for MRPS34 gene: 
NM_023936.1  

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000177742(uc021taj.1) ENST00000397375(uc002cmo.3) ENST00000569585

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23 AceView cDNA sequences:

CR601645 CR592983 AA847546 CR594183 NM_023936 BC001182 CR592964 CR615531 
CR609675 CR623189 CR593200 CR622418 CR598200 CR593465 CR594040 CR615610 
BX401807 BI049762 AW438851 BV179011 AW882091 BG315320 BF832672 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS34    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e
SP1:                    -           -                           
SP2:                    -                                       
SP3:                    -                                       
SP4:                                -                           


ECgene alternative splicing isoforms for MRPS34

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MRPS34 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAACCCTGGG
MRPS34 Expression
About this image

MRPS34 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

MRPS34 Protein Expression
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for MRPS34 gene from Selected species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Mrps341 , 5 mitochondrial ribosomal protein S341, 5 83.18(n)1
89.45(a)1
  17 (12.53 cM)5
790441  NM_023260.11  NP_075749.11 
 248951165 
chicken
(Gallus gallus)
Aves MRPS341 mitochondrial ribosomal protein S34 71.13(n)
65.46(a)
  426987  NM_001277597.1  NP_001264526.1 
lizard
(Anolis carolinensis)
Reptilia MRPS346
mitochondrial ribosomal protein S34
53(a)
1 ↔ 1
AAWZ02039731(3334-6348)
African clawed frog
(Xenopus laevis)
Amphibia mrps34-prov2 mitochondrial ribosomal protein S34 75.98(n)    BC046672.1 
zebrafish
(Danio rerio)
Actinopterygii mrps341 mitochondrial ribosomal protein S34 62.02(n)
59.07(a)
  795846  NM_001007376.2  NP_001007377.2 


ENSEMBL Gene Tree for MRPS34 (if available)
TreeFam Gene Tree for MRPS34 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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1 SNPs for MRPS34    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs115524311,2,4
----see VAR_0520502 mis40--------

HapMap Linkage Disequilibrium report for MRPS34 (1821891 - 1823156 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for MRPS34 (see all 20):    About this table    
Variant IDTypeSubtypePubMed ID
esv2422427CNV Duplication17116639
nsv904954CNV Loss21882294
nsv905030CNV Loss21882294
dgv2541n71CNV Loss21882294
nsv457336CNV Loss19166990
dgv2540n71CNV Loss21882294
nsv905017CNV Loss21882294
dgv2539n71CNV Loss21882294
nsv905034CNV Loss21882294
nsv518641CNV Loss19592680

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 611994    OMIM disorders: --


MRPS34 for disorders           About GeneDecksing

Genetic Association Database (GAD): MRPS34
Human Genome Epidemiology (HuGE) Navigator: MRPS34 (1 document)

Export disorders for MRPS34 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for MRPS34 gene, integrated from 10 sources (see all 23):
(articles sorted by number of sources associating them with MRPS34)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2 Koc E.C.... Spremulli L.L. (J. Biol. Chem. 2001)
  4. Binding of the human homolog of the Drosophila discs large tumor suppressor protein to the mitochondrial ribosomal protein MRP-S34. (PubMed id 12507520)1, 9 Ogawa F....Akiyama T. (Biochem. Biophys. Res. Commun. 2003)
  5. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
  6. p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability. (PubMed id 22904065)1 Yagi M....Kang D. (Nucleic Acids Res. 2012)
  7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
  8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
  9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
  10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 65993 HGNC: 16618 AceView: MRPS34 Ensembl:ENSG00000074071 euGenes: HUgn65993
ECgene: MRPS34 H-InvDB: MRPS34

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for MRPS34 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for MRPS34 gene:
Search GeneIP for patents involving MRPS34

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS34
 inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRPS34
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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