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Aliases for MRPS34 Gene

Aliases for MRPS34 Gene

  • Mitochondrial Ribosomal Protein S34 2 3
  • MRP-S34 3 4
  • MRPS12 3 6
  • S34mt 3 4
  • 28S Ribosomal Protein S34, Mitochondrial 3
  • MRP-S12 3

External Ids for MRPS34 Gene

Previous GeneCards Identifiers for MRPS34 Gene

  • GC16M001839
  • GC16M001761
  • GC16M001821

Summaries for MRPS34 Gene

Entrez Gene Summary for MRPS34 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for MRPS34 Gene

MRPS34 (Mitochondrial Ribosomal Protein S34) is a Protein Coding gene. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS34 Gene

Genomics for MRPS34 Gene

Regulatory Elements for MRPS34 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPS34 Gene

1,771,890 bp from pter
1,773,155 bp from pter
1,266 bases
Minus strand

Genomic View for MRPS34 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS34 Gene

Proteins for MRPS34 Gene

  • Protein details for MRPS34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S34, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q9BVI7

    Protein attributes for MRPS34 Gene

    218 amino acids
    Molecular mass:
    25650 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins

neXtProt entry for MRPS34 Gene

Proteomics data for MRPS34 Gene at MOPED

Post-translational modifications for MRPS34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS34 Gene

Antibody Products

No data available for DME Specific Peptides for MRPS34 Gene

Domains for MRPS34 Gene

Gene Families for MRPS34 Gene

  • MRPS :Mitochondrial ribosomal proteins / small subunits

Protein Domains for MRPS34 Gene


Suggested Antigen Peptide Sequences for MRPS34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPS34: view

No data available for UniProtKB/Swiss-Prot for MRPS34 Gene

Function for MRPS34 Gene

Phenotypes for MRPS34 Gene

GenomeRNAi human phenotypes for MRPS34:
genes like me logo Genes that share phenotypes with MRPS34: view

Animal Model Products

miRNA for MRPS34 Gene

miRTarBase miRNAs that target MRPS34

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS34

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPS34 Gene

Localization for MRPS34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS34 Gene


Subcellular locations from

Jensen Localization Image for MRPS34 Gene COMPARTMENTS Subcellular localization image for MRPS34 gene
Compartment Confidence
mitochondrion 5
peroxisome 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRPS34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS34: view

Pathways for MRPS34 Gene

SuperPathways for MRPS34 Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 CFTR translational fidelity (class I mutations)
4 Disease
5 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
genes like me logo Genes that share pathways with MRPS34: view

Pathways by source for MRPS34 Gene

1 KEGG pathway for MRPS34 Gene
1 GeneGo (Thomson Reuters) pathway for MRPS34 Gene

Gene Ontology (GO) - Biological Process for MRPS34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS34: view

Transcripts for MRPS34 Gene

mRNA/cDNA for MRPS34 Gene

Unigene Clusters for MRPS34 Gene

Mitochondrial ribosomal protein S34:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS34

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS34 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e
SP1: - -
SP2: -
SP3: -
SP4: -

Relevant External Links for MRPS34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS34 Gene

mRNA expression in normal human tissues for MRPS34 Gene

Protein differential expression in normal tissues for MRPS34 Gene

This gene is overexpressed in Nasal epithelium (35.3) and Breast (11.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS34 Gene

SOURCE GeneReport for Unigene cluster for MRPS34 Gene Hs.720388

genes like me logo Genes that share expressions with MRPS34: view

Expression partners for MRPS34 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS34 Gene

Orthologs for MRPS34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPS34 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS34 35
  • 84.1 (n)
  • 83.94 (a)
MRPS34 36
  • 84 (a)
(Canis familiaris)
Mammalia MRPS34 35
  • 79.53 (n)
  • 74.88 (a)
MRPS34 36
  • 73 (a)
(Mus musculus)
Mammalia Mrps34 35
  • 83.18 (n)
  • 89.45 (a)
Mrps34 16
Mrps34 36
  • 89 (a)
(Pan troglodytes)
Mammalia MRPS34 35
  • 99.54 (n)
  • 100 (a)
MRPS34 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrps34 35
  • 82.57 (n)
  • 88.53 (a)
(Monodelphis domestica)
Mammalia MRPS34 36
  • 75 (a)
(Gallus gallus)
Aves MRPS34 35
  • 71.13 (n)
  • 65.46 (a)
MRPS34 36
  • 62 (a)
(Anolis carolinensis)
Reptilia MRPS34 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps34 35
  • 61.84 (n)
  • 61.35 (a)
Str.8211 35
African clawed frog
(Xenopus laevis)
Amphibia mrps34-prov 35
(Danio rerio)
Actinopterygii mrps34 35
  • 62.02 (n)
  • 59.07 (a)
mrps34 36
  • 59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2892 36
  • 31 (a)
Species with no ortholog for MRPS34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS34 Gene

Gene Tree for MRPS34 (if available)
Gene Tree for MRPS34 (if available)

Paralogs for MRPS34 Gene

No data available for Paralogs for MRPS34 Gene

Variants for MRPS34 Gene

Sequence variations from dbSNP and Humsavar for MRPS34 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
VAR_052050 -

Structural Variations from Database of Genomic Variants (DGV) for MRPS34 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904954 CNV Loss 21882294
nsv905017 CNV Loss 21882294
nsv518641 CNV Loss 19592680
nsv457335 CNV Loss 19166990
dgv2538n71 CNV Loss 21882294
nsv517196 CNV Gain+Loss 19592680
nsv905023 CNV Gain 21882294
dgv2539n71 CNV Loss 21882294
dgv2540n71 CNV Loss 21882294
nsv457336 CNV Loss 19166990
nsv905030 CNV Loss 21882294
nsv471069 CNV Loss 18288195
dgv2541n71 CNV Loss 21882294
nsv905031 CNV Gain+Loss 21882294
dgv2542n71 CNV Loss 21882294
nsv905034 CNV Loss 21882294
nsv827500 CNV Gain 20364138
dgv2543n71 CNV Loss 21882294
nsv905039 CNV Loss 21882294

Relevant External Links for MRPS34 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS34 Gene

Disorders for MRPS34 Gene

Relevant External Links for MRPS34

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MRPS34 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MRPS34 Gene

Publications for MRPS34 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. Binding of the human homolog of the Drosophila discs large tumor suppressor protein to the mitochondrial ribosomal protein MRP-S34. (PMID: 12507520) Ogawa F. … Akiyama T. (Biochem. Biophys. Res. Commun. 2003) 3 23
  4. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for MRPS34 Gene

Sources for MRPS34 Gene

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