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Aliases for MRPS34 Gene

Aliases for MRPS34 Gene

  • Mitochondrial Ribosomal Protein S34 2 3 5
  • MRP-S34 3 4
  • S34mt 3 4
  • Mitochondrial 28S Ribosomal Protein S34 3
  • MRP-S12 3
  • MRPS12 3

External Ids for MRPS34 Gene

Previous GeneCards Identifiers for MRPS34 Gene

  • GC16M001839
  • GC16M001761
  • GC16M001821

Summaries for MRPS34 Gene

Entrez Gene Summary for MRPS34 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

GeneCards Summary for MRPS34 Gene

MRPS34 (Mitochondrial Ribosomal Protein S34) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance.

UniProtKB/Swiss-Prot for MRPS34 Gene

  • Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS34 Gene

Genomics for MRPS34 Gene

Regulatory Elements for MRPS34 Gene

Enhancers for MRPS34 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPS34 on UCSC Golden Path with GeneCards custom track

Promoters for MRPS34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPS34 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPS34 Gene

1,771,890 bp from pter
1,773,155 bp from pter
1,266 bases
Minus strand

Genomic View for MRPS34 Gene

Genes around MRPS34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS34 Gene

Proteins for MRPS34 Gene

  • Protein details for MRPS34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S34, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q9BVI7

    Protein attributes for MRPS34 Gene

    218 amino acids
    Molecular mass:
    25650 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS34 Gene

neXtProt entry for MRPS34 Gene

Proteomics data for MRPS34 Gene at MOPED

Post-translational modifications for MRPS34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS34 Gene

No data available for DME Specific Peptides for MRPS34 Gene

Domains & Families for MRPS34 Gene

Gene Families for MRPS34 Gene

Protein Domains for MRPS34 Gene


Suggested Antigen Peptide Sequences for MRPS34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPS34: view

No data available for UniProtKB/Swiss-Prot for MRPS34 Gene

Function for MRPS34 Gene

Molecular function for MRPS34 Gene

UniProtKB/Swiss-Prot Function:
Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation.

Phenotypes for MRPS34 Gene

genes like me logo Genes that share phenotypes with MRPS34: view

Animal Model Products

miRNA for MRPS34 Gene

miRTarBase miRNAs that target MRPS34

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS34 Gene

Localization for MRPS34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS34 Gene


Subcellular locations from

Jensen Localization Image for MRPS34 Gene COMPARTMENTS Subcellular localization image for MRPS34 gene
Compartment Confidence
mitochondrion 5
peroxisome 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRPS34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPS34: view

Pathways & Interactions for MRPS34 Gene

genes like me logo Genes that share pathways with MRPS34: view

Gene Ontology (GO) - Biological Process for MRPS34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation ISS,TAS --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPS34: view

No data available for SIGNOR curated interactions for MRPS34 Gene

Drugs & Compounds for MRPS34 Gene

No Compound Related Data Available

Transcripts for MRPS34 Gene

mRNA/cDNA for MRPS34 Gene

Unigene Clusters for MRPS34 Gene

Mitochondrial ribosomal protein S34:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS34 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e
SP1: - -
SP2: -
SP3: -
SP4: -

Relevant External Links for MRPS34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS34 Gene

mRNA expression in normal human tissues for MRPS34 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS34 Gene

This gene is overexpressed in Nasal epithelium (35.3) and Breast (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS34 Gene

SOURCE GeneReport for Unigene cluster for MRPS34 Gene Hs.720388

genes like me logo Genes that share expression patterns with MRPS34: view

Protein tissue co-expression partners for MRPS34 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS34 Gene

Orthologs for MRPS34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPS34 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS34 35
  • 84.1 (n)
  • 83.94 (a)
MRPS34 36
  • 84 (a)
(Canis familiaris)
Mammalia MRPS34 35
  • 79.53 (n)
  • 74.88 (a)
MRPS34 36
  • 73 (a)
(Mus musculus)
Mammalia Mrps34 35
  • 83.18 (n)
  • 89.45 (a)
Mrps34 16
Mrps34 36
  • 89 (a)
(Pan troglodytes)
Mammalia MRPS34 35
  • 99.54 (n)
  • 100 (a)
MRPS34 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrps34 35
  • 82.57 (n)
  • 88.53 (a)
(Monodelphis domestica)
Mammalia MRPS34 36
  • 75 (a)
(Gallus gallus)
Aves MRPS34 35
  • 71.13 (n)
  • 65.46 (a)
MRPS34 36
  • 62 (a)
(Anolis carolinensis)
Reptilia MRPS34 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps34 35
  • 61.84 (n)
  • 61.35 (a)
Str.8211 35
African clawed frog
(Xenopus laevis)
Amphibia mrps34-prov 35
(Danio rerio)
Actinopterygii mrps34 35
  • 62.02 (n)
  • 59.07 (a)
mrps34 36
  • 59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2892 36
  • 31 (a)
Species with no ortholog for MRPS34:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS34 Gene

Gene Tree for MRPS34 (if available)
Gene Tree for MRPS34 (if available)

Paralogs for MRPS34 Gene

No data available for Paralogs for MRPS34 Gene

Variants for MRPS34 Gene

Sequence variations from dbSNP and Humsavar for MRPS34 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_052050 -
rs760013791 -- 1,774,696(+) GGTTA(-/G)GGCTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRPS34 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv904954 CNV Loss 21882294
nsv905017 CNV Loss 21882294
nsv518641 CNV Loss 19592680
nsv457335 CNV Loss 19166990
dgv2538n71 CNV Loss 21882294
nsv517196 CNV Gain+Loss 19592680
nsv905023 CNV Gain 21882294
dgv2539n71 CNV Loss 21882294
dgv2540n71 CNV Loss 21882294
nsv457336 CNV Loss 19166990
nsv905030 CNV Loss 21882294
nsv471069 CNV Loss 18288195
dgv2541n71 CNV Loss 21882294
nsv905031 CNV Gain+Loss 21882294
dgv2542n71 CNV Loss 21882294
nsv905034 CNV Loss 21882294
nsv827500 CNV Gain 20364138
dgv2543n71 CNV Loss 21882294
nsv905039 CNV Loss 21882294

Variation tolerance for MRPS34 Gene

Residual Variation Intolerance Score: 48.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.35; 97.09% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRPS34 Gene

Disorders for MRPS34 Gene

Relevant External Links for MRPS34

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPS34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS34 Gene

Publications for MRPS34 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. Binding of the human homolog of the Drosophila discs large tumor suppressor protein to the mitochondrial ribosomal protein MRP-S34. (PMID: 12507520) Ogawa F. … Akiyama T. (Biochem. Biophys. Res. Commun. 2003) 3 23
  3. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for MRPS34 Gene

Sources for MRPS34 Gene