MRPS34 Gene
protein-coding GIFtS: 47
GCID: GC16M001821
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mitochondrial ribosomal protein S34
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Aliases
for MRPS34 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein S341 2 | | MRPS122 5 | | MRP-S121 2 | | MGC26161 | | MRP-S342 3 | | 28S Ribosomal Protein S34, Mitochondrial2 | | S34mt2 3 | | |
Export aliases for MRPS34 gene to outside databasesPrevious GC identifers: GC16M001839 GC16M001761 |
Summaries
for MRPS34 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPS34:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein.Alternate splice variants of this gene have been described but their full-length nature has not been determined.(provided by RefSeq, Jul 2008)
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Genomic Views
for MRPS34 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPS34 gene promoter:
USF1 Tal-1 Pax-5 Olf-1 YY1 E47 Roaz CP2 USF-1 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPS34
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS34 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3MRPS34 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M001821: view genomic region
(about GC identifiers)
Start:
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1,821,891 bp from pter |
End:
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1,823,156 bp from pter |
Size:
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1,266 bases |
Orientation:
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minus strand |
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Proteins
for MRPS34 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RT34_HUMAN, P82930 (See
protein sequence)Recommended Name: 28S ribosomal protein S34, mitochondrial Size: 218 amino acids; 25650 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinctproteins
Subcellular location: Mitochondrion
Secondary accessions: Q9BVI7Explore the universe of human proteins at neXtProt for MRPS34: NX_P82930
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P82930
MRPS34 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_076425.1
ENSEMBL proteins: ENSP00000456678 ENSP00000177742 ENSP00000380531 ENSP00000455202
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MRPS34 for ontologies About GeneDecksing
MRPS34 Antibody Products:
Assay Products for MRPS34: |
Protein
Domains /
Families
for MRPS34 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: P82930 |
Function
for MRPS34 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS34 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS34
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRPS34 (NM_023936) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS34 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS34 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS34 |
1 GenomeRNAi human phenotype for MRPS34:
|
Pathways & Interactions
for MRPS34 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MRPS34
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/241 Interacting proteins for MRPS34 (P829302, 3 ENSP000003805314) via UniProtKB, MINT, STRING, and/or I2D (see all 241)About this table
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Drugs & Compounds
for MRPS34 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPS34
Search CenterWatch for drugs/clinical trials and news about MRPS34 / RT34
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Transcripts
for MRPS34 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPS34 gene: NM_023936.1 Unigene Cluster for MRPS34: Mitochondrial ribosomal protein S34 Hs.720388 [show with all ESTs]Unigene Representative Sequence: BF2060875 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000568734 ENST00000177742(uc021taj.1) ENST00000397375(uc002cmo.3)
ENST00000568758 ENST00000569585
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS34 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS34
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRPS34 (NM_023936) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS34 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS34 |
Additional cDNA sequence: BC001182.1 EF036486.1 12 DOTS entries: DT.313180 DT.100657835 DT.95308475 DT.92445596 DT.95308509 DT.95308477 DT.91719170 DT.100657833 DT.100848619 DT.95308510 DT.100718551 DT.95308481 23 AceView cDNA sequences: CR623189 CR615531 CR593200 AA847546 NM_023936 CR601645 CR592964 CR622418 CR609675 CR593465 CR615610 CR592983 BC001182 CR594040 CR594183 CR598200 BX401807 BI049762 AW438851 BV179011 AW882091 BG315320 BF832672
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS34 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e |
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| SP1: | | | | | | | - | | | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for MRPS34
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Expression
for MRPS34 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPS34 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAACCCTGGG
About this image
See MRPS34 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPS34
SOURCE GeneReport for Unigene cluster: Hs.720388
SABiosciences Custom PCR Arrays for MRPS34
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS34
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPS34 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS34 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS34 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS34 |
Orthologs
for MRPS34 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MRPS34 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for MRPS34 (if available)
TreeFam Gene Tree for MRPS34 (if available) |
Paralogs
for MRPS34 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MRPS34 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPS34 (1821891 - 1823156 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for MRPS34
5 CNVs: 49667 29999 5329 49668 49666 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS34 |
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Disorders
/ Diseases
for MRPS34 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRPS34 for disorders About MalaCards
MRPS34 for disorders About GeneDecksing
OMIM gene information: 611994
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MRPS34 (1 document)
Export disorders for MRPS34 gene to outside databases
|
Publications
for MRPS34 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPS34 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with MRPS34) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2 Koc E.C.... Spremulli L.L. (2001)
- Binding of the human homolog of the Drosophila discs large tumor suppressor protein to the mitochondrial ribosomal protein MRP-S34. (PubMed id 12507520)1, 9 Ogawa F....Akiyama T. (2003)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
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External Searches for MRPS34 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MRPS34 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPS34 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPS34 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPS34 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MRPS34 gene:
Search GeneIP for patents involving MRPS34
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPS34 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | OriGene Antibodies for MRPS34 | | OriGene shRNA RFP for MRPS34 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPS34 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS34 | | | OriGene Protein Over-expression Lysate for MRPS34 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRPS34 | | OriGene 3'-UTR Clone for MRPS34 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS34 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS34 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MRPS34 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MRPS34 | | OriGene Custom Protein Services for MRPS34 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPS34 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS34 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS34 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPS34 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS34 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS34 |
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| | | | Search Tocris compounds for MRPS34 |
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 | | | MRPS34 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS34 |
|  |  |  | | | | ThermoFisher Antibodies for MRPS34 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS34 |
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