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Aliases for MRPS33 Gene

Aliases for MRPS33 Gene

  • Mitochondrial Ribosomal Protein S33 2 3
  • MRP-S33 3 4
  • S33mt 3 4
  • 28S Ribosomal Protein S33, Mitochondrial 3
  • CGI-139 3
  • PTD003 3

External Ids for MRPS33 Gene

Previous GeneCards Identifiers for MRPS33 Gene

  • GC07M138976
  • GC07M140036
  • GC07M140113
  • GC07M140159
  • GC07M140352
  • GC07M140705
  • GC07M135002

Summaries for MRPS33 Gene

Entrez Gene Summary for MRPS33 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that is one of the more highly conserved mitochondrial ribosomal proteins among mammals, Drosophila and C. elegans. Splice variants that differ in the 5' UTR have been found for this gene; all variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q, 4p, 4q, and 20q [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS33 Gene

MRPS33 (Mitochondrial Ribosomal Protein S33) is a Protein Coding gene. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS33 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS33 Gene

Genomics for MRPS33 Gene

Regulatory Elements for MRPS33 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPS33 Gene

Start:
141,006,054 bp from pter
End:
141,015,228 bp from pter
Size:
9,175 bases
Orientation:
Minus strand

Genomic View for MRPS33 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS33 Gene

Proteins for MRPS33 Gene

  • Protein details for MRPS33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y291-RT33_HUMAN
    Recommended name:
    28S ribosomal protein S33, mitochondrial
    Protein Accession:
    Q9Y291
    Secondary Accessions:

    Protein attributes for MRPS33 Gene

    Size:
    106 amino acids
    Molecular mass:
    12629 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins

neXtProt entry for MRPS33 Gene

Proteomics data for MRPS33 Gene at MOPED

Post-translational modifications for MRPS33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS33 Gene

Antibody Products

No data available for DME Specific Peptides for MRPS33 Gene

Domains for MRPS33 Gene

Gene Families for MRPS33 Gene

HGNC:
  • MRPS :Mitochondrial ribosomal proteins / small subunits

Protein Domains for MRPS33 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPS33 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPS33: view

No data available for UniProtKB/Swiss-Prot for MRPS33 Gene

Function for MRPS33 Gene

Gene Ontology (GO) - Molecular Function for MRPS33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
genes like me logo Genes that share ontologies with MRPS33: view
genes like me logo Genes that share phenotypes with MRPS33: view

Animal Model Products

miRNA for MRPS33 Gene

miRTarBase miRNAs that target MRPS33

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS33

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPS33 Gene

Localization for MRPS33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS33 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS33 Gene COMPARTMENTS Subcellular localization image for MRPS33 gene
Compartment Confidence
mitochondrion 5
nucleus 3

Gene Ontology (GO) - Cellular Components for MRPS33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit NAS 11279123
genes like me logo Genes that share ontologies with MRPS33: view

Pathways for MRPS33 Gene

SuperPathways for MRPS33 Gene

No Data Available

Interacting Proteins for MRPS33 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000320567%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000447547%0d%0a9606.ENSP00000421307%0d%0a
Selected Interacting proteins: ENSP00000320567 Q9Y291-RT33_HUMAN for MRPS33 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MRPS33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPS33: view

No data available for Pathways by source for MRPS33 Gene

Transcripts for MRPS33 Gene

Unigene Clusters for MRPS33 Gene

Mitochondrial ribosomal protein S33:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS33

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS33 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3:

Relevant External Links for MRPS33 Gene

GeneLoc Exon Structure for
MRPS33
ECgene alternative splicing isoforms for
MRPS33

Expression for MRPS33 Gene

mRNA expression in normal human tissues for MRPS33 Gene

Protein differential expression in normal tissues for MRPS33 Gene

This gene is overexpressed in Breast (27.4) and Lung (25.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS33 Gene

SOURCE GeneReport for Unigene cluster for MRPS33 Gene Hs.416207

genes like me logo Genes that share expressions with MRPS33: view

Expression partners for MRPS33 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS33 Gene

Orthologs for MRPS33 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS33 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPS33 35
  • 84.28 (n)
  • 83.02 (a)
MRPS33 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS33 35
  • 84.59 (n)
  • 83.96 (a)
-- 36
  • 84 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Mrps33 35
  • 82.7 (n)
  • 82.08 (a)
Mrps33 16
Mrps33 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPS33 35
  • 99.06 (n)
  • 100 (a)
MRPS33 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps33 35
  • 82.37 (n)
  • 84.62 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS33 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS33 35
  • 73.9 (n)
  • 75.47 (a)
MRPS33 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPS33 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps33 35
  • 65.72 (n)
  • 72.64 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29741 35
zebrafish
(Danio rerio)
Actinopterygii mrps33 35
  • 65.72 (n)
  • 62.26 (a)
mrps33 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002777 35
  • 56.67 (n)
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS33 35
  • 53.8 (n)
  • 60.4 (a)
mRpS33 36
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrps-33 36
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
OneToOne
Species with no ortholog for MRPS33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS33 Gene

ENSEMBL:
Gene Tree for MRPS33 (if available)
TreeFam:
Gene Tree for MRPS33 (if available)

Paralogs for MRPS33 Gene

Pseudogenes.org Pseudogenes for MRPS33 Gene

genes like me logo Genes that share paralogs with MRPS33: view

No data available for Paralogs for MRPS33 Gene

Variants for MRPS33 Gene

Sequence variations from dbSNP and Humsavar for MRPS33 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs6662 -- 141,006,357(+) CAATA(G/T)GTGGA utr-variant-3-prime
rs9274 -- 141,006,231(+) GCCAA(A/G)ATAAT utr-variant-3-prime
rs11288 -- 141,006,228(+) AAGGC(A/C)AANAT utr-variant-3-prime
rs38733 -- 141,005,684(+) TTAAA(C/T)TCCCT downstream-variant-500B
rs38734 -- 141,006,908(+) TACAC(A/T)GAGAC intron-variant

Relevant External Links for MRPS33 Gene

HapMap Linkage Disequilibrium report
MRPS33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPS33 Gene

Disorders for MRPS33 Gene

Relevant External Links for MRPS33

Genetic Association Database (GAD)
MRPS33
Human Genome Epidemiology (HuGE) Navigator
MRPS33

No disorders were found for MRPS33 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MRPS33 Gene

Publications for MRPS33 Gene

  1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  2. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for MRPS33 Gene

Sources for MRPS33 Gene

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