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Aliases for MRPS33 Gene

Aliases for MRPS33 Gene

  • Mitochondrial Ribosomal Protein S33 2 3 5
  • MRP-S33 3 4
  • S33mt 3 4
  • 28S Ribosomal Protein S33, Mitochondrial 3
  • CGI-139 3
  • PTD003 3

External Ids for MRPS33 Gene

Previous GeneCards Identifiers for MRPS33 Gene

  • GC07M138976
  • GC07M140036
  • GC07M140113
  • GC07M140159
  • GC07M140352
  • GC07M140705
  • GC07M135002

Summaries for MRPS33 Gene

Entrez Gene Summary for MRPS33 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that is one of the more highly conserved mitochondrial ribosomal proteins among mammals, Drosophila and C. elegans. Splice variants that differ in the 5' UTR have been found for this gene; all variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q, 4p, 4q, and 20q [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS33 Gene

MRPS33 (Mitochondrial Ribosomal Protein S33) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS33 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS33 Gene

Genomics for MRPS33 Gene

Regulatory Elements for MRPS33 Gene

Enhancers for MRPS33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F141001 0.4 ENCODE 12.6 +12.1 12111 2.4 SOX13 BCOR PKNOX1 MLX ZNF133 RARA NR2F6 ZNF652 MIXL1 THAP11 TMEM178B MRPS33 NDUFB2-AS1 NDUFB2 CCT4P1
GH07F140922 0.5 ENCODE 11.5 +92.7 92653 0.3 POLR2H IKZF1 MRPS33 NDUFB2 BRAF RNU6-85P
GH07F140992 0.2 ENCODE 11.1 +22.6 22593 0.2 GATAD2A ELF3 FOXA3 HMG20A ZNF48 RAD21 ZNF644 RARA ZNF217 MBD2 MRPS33 BRAF NDUFB2-AS1 NDUFB2 CCT4P1 LOC105375536
GH07F140923 0.2 ENCODE 11.1 +90.6 90605 2.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 NDUFB2 MRPS33 TAS2R6P NDUFB2-AS1 ADCK2 BRAF RNU6-85P
GH07F140719 0.4 Ensembl 10.3 +295.4 295428 0.4 ZNF316 IKZF1 CEBPB MAFG NFE2 EMSY NDUFB2-AS1 NDUFB2 MRPS33 GC07P140760
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MRPS33 on UCSC Golden Path with GeneCards custom track

Promoters for MRPS33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000314189 528 2200 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for MRPS33 Gene

Chromosome:
7
Start:
141,002,610 bp from pter
End:
141,015,228 bp from pter
Size:
12,619 bases
Orientation:
Minus strand

Genomic View for MRPS33 Gene

Genes around MRPS33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS33 Gene

Proteins for MRPS33 Gene

  • Protein details for MRPS33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y291-RT33_HUMAN
    Recommended name:
    28S ribosomal protein S33, mitochondrial
    Protein Accession:
    Q9Y291

    Protein attributes for MRPS33 Gene

    Size:
    106 amino acids
    Molecular mass:
    12629 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS33 Gene

neXtProt entry for MRPS33 Gene

Post-translational modifications for MRPS33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS33 Gene

No data available for DME Specific Peptides for MRPS33 Gene

Domains & Families for MRPS33 Gene

Gene Families for MRPS33 Gene

Protein Domains for MRPS33 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPS33 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPS33: view

No data available for UniProtKB/Swiss-Prot for MRPS33 Gene

Function for MRPS33 Gene

Gene Ontology (GO) - Molecular Function for MRPS33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
genes like me logo Genes that share ontologies with MRPS33: view
genes like me logo Genes that share phenotypes with MRPS33: view

Animal Model Products

miRNA for MRPS33 Gene

miRTarBase miRNAs that target MRPS33

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS33 Gene

Localization for MRPS33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS33 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS33 Gene COMPARTMENTS Subcellular localization image for MRPS33 gene
Compartment Confidence
mitochondrion 5
nucleus 3

Gene Ontology (GO) - Cellular Components for MRPS33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IBA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit NAS 11279123
GO:0005840 ribosome IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MRPS33: view

Pathways & Interactions for MRPS33 Gene

genes like me logo Genes that share pathways with MRPS33: view

Interacting Proteins for MRPS33 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000320567%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000447547%0d%0a9606.ENSP00000421307%0d%0a
Selected Interacting proteins: Q9Y291-RT33_HUMAN ENSP00000320567 for MRPS33 Gene via IID STRING

Gene Ontology (GO) - Biological Process for MRPS33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS33: view

No data available for SIGNOR curated interactions for MRPS33 Gene

Transcripts for MRPS33 Gene

Unigene Clusters for MRPS33 Gene

Mitochondrial ribosomal protein S33:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS33 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3:

Relevant External Links for MRPS33 Gene

GeneLoc Exon Structure for
MRPS33
ECgene alternative splicing isoforms for
MRPS33

Expression for MRPS33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPS33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS33 Gene

This gene is overexpressed in Breast (27.4) and Lung (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS33 Gene



Protein tissue co-expression partners for MRPS33 Gene

NURSA nuclear receptor signaling pathways regulating expression of MRPS33 Gene:

MRPS33

SOURCE GeneReport for Unigene cluster for MRPS33 Gene:

Hs.416207
genes like me logo Genes that share expression patterns with MRPS33: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS33 Gene

Orthologs for MRPS33 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS33 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS33 34 35
  • 99.06 (n)
dog
(Canis familiaris)
Mammalia MRPS33 34
  • 84.59 (n)
-- 35
  • 84 (a)
OneToMany
-- 35
  • 75 (a)
OneToMany
cow
(Bos Taurus)
Mammalia MRPS33 34 35
  • 84.28 (n)
mouse
(Mus musculus)
Mammalia Mrps33 34 16 35
  • 82.7 (n)
rat
(Rattus norvegicus)
Mammalia Mrps33 34
  • 82.37 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 78 (a)
OneToMany
-- 35
  • 78 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS33 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS33 34 35
  • 73.9 (n)
lizard
(Anolis carolinensis)
Reptilia MRPS33 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps33 34
  • 65.72 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29741 34
zebrafish
(Danio rerio)
Actinopterygii mrps33 34 35
  • 65.72 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002777 34
  • 56.67 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpS33 34 35
  • 53.8 (n)
worm
(Caenorhabditis elegans)
Secernentea mrps-33 35
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
OneToOne
Species where no ortholog for MRPS33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS33 Gene

ENSEMBL:
Gene Tree for MRPS33 (if available)
TreeFam:
Gene Tree for MRPS33 (if available)

Paralogs for MRPS33 Gene

Pseudogenes.org Pseudogenes for MRPS33 Gene

genes like me logo Genes that share paralogs with MRPS33: view

No data available for Paralogs for MRPS33 Gene

Variants for MRPS33 Gene

Sequence variations from dbSNP and Humsavar for MRPS33 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10215245 -- 141,011,917(+) CTGAG(A/G)TGGGA intron-variant
rs10276106 -- 141,014,316(+) ACAAT(C/T)TCAAC intron-variant, downstream-variant-500B
rs10550694 -- 141,008,802(+) AATAA(-/T)TTTTT intron-variant
rs111380983 -- 141,011,989(+) AGAAA(-/AAAAAAC)AAAAA intron-variant
rs111687394 -- 141,014,154(+) TGCCA(A/G)GTTCT intron-variant, splice-acceptor-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS33 Gene

Variant ID Type Subtype PubMed ID
dgv6645n100 CNV gain 25217958
nsv473706 CNV novel sequence insertion 20440878
nsv476456 CNV novel sequence insertion 20440878

Variation tolerance for MRPS33 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 51.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS33 Gene

Disorders for MRPS33 Gene

Relevant External Links for MRPS33

Genetic Association Database (GAD)
MRPS33
Human Genome Epidemiology (HuGE) Navigator
MRPS33
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS33

No disorders were found for MRPS33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS33 Gene

Publications for MRPS33 Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4 64
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64

Products for MRPS33 Gene

Sources for MRPS33 Gene

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