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Aliases for MRPS33 Gene

Aliases for MRPS33 Gene

  • Mitochondrial Ribosomal Protein S33 2 3 5
  • MRP-S33 3 4
  • S33mt 3 4
  • CGI-139 3
  • PTD003 3

External Ids for MRPS33 Gene

Previous GeneCards Identifiers for MRPS33 Gene

  • GC07M138976
  • GC07M140036
  • GC07M140113
  • GC07M140159
  • GC07M140352
  • GC07M140705
  • GC07M135002

Summaries for MRPS33 Gene

Entrez Gene Summary for MRPS33 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that is one of the more highly conserved mitochondrial ribosomal proteins among mammals, Drosophila and C. elegans. Splice variants that differ in the 5' UTR have been found for this gene; all variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q, 4p, 4q, and 20q [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS33 Gene

MRPS33 (Mitochondrial Ribosomal Protein S33) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS33 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS33 Gene

Genomics for MRPS33 Gene

Regulatory Elements for MRPS33 Gene

Enhancers for MRPS33 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPS33 on UCSC Golden Path with GeneCards custom track

Promoters for MRPS33 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPS33 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPS33 Gene

141,002,610 bp from pter
141,015,228 bp from pter
12,619 bases
Minus strand

Genomic View for MRPS33 Gene

Genes around MRPS33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS33 Gene

Proteins for MRPS33 Gene

  • Protein details for MRPS33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S33, mitochondrial
    Protein Accession:

    Protein attributes for MRPS33 Gene

    106 amino acids
    Molecular mass:
    12629 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS33 Gene

neXtProt entry for MRPS33 Gene

Proteomics data for MRPS33 Gene at MOPED

Post-translational modifications for MRPS33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS33 Gene

Antibody Products

  • Abcam antibodies for RT33

No data available for DME Specific Peptides for MRPS33 Gene

Domains & Families for MRPS33 Gene

Gene Families for MRPS33 Gene

Protein Domains for MRPS33 Gene


Suggested Antigen Peptide Sequences for MRPS33 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPS33: view

No data available for UniProtKB/Swiss-Prot for MRPS33 Gene

Function for MRPS33 Gene

genes like me logo Genes that share phenotypes with MRPS33: view

Animal Model Products

miRNA for MRPS33 Gene

miRTarBase miRNAs that target MRPS33

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS33 Gene

Localization for MRPS33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS33 Gene


Subcellular locations from

Jensen Localization Image for MRPS33 Gene COMPARTMENTS Subcellular localization image for MRPS33 gene
Compartment Confidence
mitochondrion 5
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for MRPS33 Gene

Pathways & Interactions for MRPS33 Gene

genes like me logo Genes that share pathways with MRPS33: view

Interacting Proteins for MRPS33 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000320567 Q9Y291-RT33_HUMAN for MRPS33 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for MRPS33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0006996 organelle organization TAS --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPS33: view

No data available for SIGNOR curated interactions for MRPS33 Gene

Drugs & Compounds for MRPS33 Gene

No Compound Related Data Available

Transcripts for MRPS33 Gene

Unigene Clusters for MRPS33 Gene

Mitochondrial ribosomal protein S33:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS33 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2: - -

Relevant External Links for MRPS33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS33 Gene

mRNA expression in normal human tissues for MRPS33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS33 Gene

This gene is overexpressed in Breast (27.4) and Lung (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS33 Gene

SOURCE GeneReport for Unigene cluster for MRPS33 Gene Hs.416207

genes like me logo Genes that share expression patterns with MRPS33: view

Protein tissue co-expression partners for MRPS33 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS33 Gene

Orthologs for MRPS33 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS33 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS33 35
  • 84.28 (n)
  • 83.02 (a)
MRPS33 36
  • 83 (a)
(Canis familiaris)
Mammalia MRPS33 35
  • 84.59 (n)
  • 83.96 (a)
-- 36
  • 84 (a)
-- 36
  • 75 (a)
(Mus musculus)
Mammalia Mrps33 35
  • 82.7 (n)
  • 82.08 (a)
Mrps33 16
Mrps33 36
  • 82 (a)
(Pan troglodytes)
Mammalia MRPS33 35
  • 99.06 (n)
  • 100 (a)
MRPS33 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrps33 35
  • 82.37 (n)
  • 84.62 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
-- 36
  • 70 (a)
-- 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS33 36
  • 71 (a)
(Gallus gallus)
Aves MRPS33 35
  • 73.9 (n)
  • 75.47 (a)
MRPS33 36
  • 75 (a)
(Anolis carolinensis)
Reptilia MRPS33 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps33 35
  • 65.72 (n)
  • 72.64 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29741 35
(Danio rerio)
Actinopterygii mrps33 35
  • 65.72 (n)
  • 62.26 (a)
mrps33 36
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002777 35
  • 56.67 (n)
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS33 35
  • 53.8 (n)
  • 60.4 (a)
mRpS33 36
  • 53 (a)
(Caenorhabditis elegans)
Secernentea mrps-33 36
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
Species with no ortholog for MRPS33:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS33 Gene

Gene Tree for MRPS33 (if available)
Gene Tree for MRPS33 (if available)

Paralogs for MRPS33 Gene Pseudogenes for MRPS33 Gene

genes like me logo Genes that share paralogs with MRPS33: view

No data available for Paralogs for MRPS33 Gene

Variants for MRPS33 Gene

Sequence variations from dbSNP and Humsavar for MRPS33 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1533933 -- 141,015,225(-) CCATT(C/G)CCACC upstream-variant-2KB
rs13307033 -- 141,016,103(+) TATAT(A/G)TGTGT upstream-variant-2KB
rs38742 -- 141,015,171(+) GTTAG(A/G)AAGGT upstream-variant-2KB
rs38743 -- 141,015,497(+) AGAAA(A/G)CATTG upstream-variant-2KB
rs246745 -- 141,016,390(+) AAACT(C/T)GGTGT upstream-variant-2KB

Variation tolerance for MRPS33 Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 51.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MRPS33 Gene

Disorders for MRPS33 Gene

Relevant External Links for MRPS33

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPS33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS33 Gene

Publications for MRPS33 Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4 67
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3

Products for MRPS33 Gene

Sources for MRPS33 Gene