MRPS33 Gene
protein-coding GIFtS: 47
GCID: GC07M140705
|
|
mitochondrial ribosomal protein S33
| |
Aliases
for MRPS33 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein S331 2 | | MRP-S332 3 | | S33mt2 3 | | CGI-1391 | | 28S Ribosomal Protein S33, Mitochondrial2 | | PTD0032 |
Export aliases for MRPS33 gene to outside databasesPrevious GC identifers: GC07M138976 GC07M140036 GC07M140113 GC07M140159 GC07M140352 GC07M135002 |
Summaries
for MRPS33 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPS33:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalianmitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunitprotein that is one of the more highly conserved mitochondrial ribosomal proteins among mammals, Drosophila and C.elegans. Splice variants that differ in the 5' UTR have been found for this gene; all variants encode the sameprotein. Pseudogenes corresponding to this gene are found on chromosomes 1q, 4p, 4q, and 20q (provided by RefSeq, Jul2008)
Gene Wiki entry for MRPS33
|
Genomic Views
for MRPS33 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPS33 gene promoter:
AREB6 Pax-6 NCX/Ncx En-1 Egr-4
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPS33
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS33 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q34 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q34MRPS33 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M140705: view genomic region
(about GC identifiers)
Start:
|
140,705,854 bp from pter |
End:
|
140,715,028 bp from pter |
Size:
|
9,175 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 140,044,284-140,053,108 |
|
Proteins
for MRPS33 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RT33_HUMAN, Q9Y291 (See
protein sequence)Recommended Name: 28S ribosomal protein S33, mitochondrial Size: 106 amino acids; 12629 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinctproteins
Subcellular location: MitochondrionExplore the universe of human proteins at neXtProt for MRPS33: NX_Q9Y291
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y291
MRPS33 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_057155.1 NP_444263.1
ENSEMBL proteins: ENSP00000376732 ENSP00000320567 ENSP00000418451 ENSP00000417287 ENSP00000420709
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MRPS33 for ontologies About GeneDecksing
MRPS33 Antibody Products:
Assay Products for MRPS33: |
Protein
Domains /
Families
for MRPS33 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPS33 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y291ProtoNet protein and cluster: Q9Y291 |
Function
for MRPS33 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS33 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS33 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MRPS33 (NM_016071) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS33 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS33 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS33 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
NAS | 11279123 |
MRPS33 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for MRPS33:
|
Pathways & Interactions
for MRPS33 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS33
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/6 Interacting proteins for MRPS33 (Q9Y2913 ENSP000003205674) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
MRPS33 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRPS33 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPS33
Search CenterWatch for drugs/clinical trials and news about MRPS33 / RT33
|
Transcripts
for MRPS33 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPS33 gene (2 alternative transcripts): NM_016071.3 NM_053035.2 Unigene Cluster for MRPS33: Mitochondrial ribosomal protein S33 Hs.416207 [show with all ESTs]Unigene Representative Sequence: BG4213339 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000393008(uc003vwd.4) ENST00000324787(uc003vwe.4) ENST00000472343
ENST00000496958 ENST00000484502 ENST00000469351 ENST00000467334 ENST00000496641
ENST00000485202
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS33 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS33 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MRPS33 (NM_016071) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS33 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS33 |
Additional cDNA sequence: AF078858.1 AF151897.1 AK024776.1 BC015462.2 BC105793.1 11 DOTS entries: DT.446315 DT.100790980 DT.100790975 DT.92428828 DT.95303066 DT.97843277 DT.75135816 DT.95303067 DT.95303069 DT.95303070 DT.95303071 24/220 AceView cDNA sequences (see all 220): AI497968 CR604037 CK819529 AA352225 BM129215 BG940609 AA313451 N44293 AA303377 BP429921 CA415597 AA070972 AA373716 AI084741 BM718274 CA313147 BM796520 AW025038 N78712 BX447774 BU531920 AA551853 W45092 AA352044
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS33 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MRPS33
|
Expression
for MRPS33 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPS33 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGACGCTCC
About this image
See MRPS33 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPS33
SOURCE GeneReport for Unigene cluster: Hs.416207
SABiosciences Custom PCR Arrays for MRPS33
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS33
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPS33 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS33 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS33 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS33 |
Orthologs
for MRPS33 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MRPS33 gene from 7/20 species (see all 20) About this table
ENSEMBL Gene Tree for MRPS33 (if available)
TreeFam Gene Tree for MRPS33 (if available) |
Paralogs
for MRPS33 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRPS33 gene
MRPS33 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for MRPS33
PGOHUM00000244275 PGOHUM00000247675 PGOHUM00000245498 PGOHUM00000246041
|
Genomic Variants
for MRPS33 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPS33 (140705854 - 140715028 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MRPS33: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS33 |
|
Disorders
/ Diseases
for MRPS33 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRPS33 for disorders About MalaCards
MRPS33 for disorders About GeneDecksing
OMIM gene information: 611993
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MRPS33 (1 document)
Export disorders for MRPS33 gene to outside databases
|
Publications
for MRPS33 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPS33 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with MRPS33) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2, 3 Koc E.C.... Spremulli L.L. (2001)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Distinct class of putative 'non-conserved' promoters in humans: comparative studies of alternative promoters of human and mouse genes. (PubMed id 17567985)1 Tsuritani K....Suzuki Y. (2007)
- Large-scale analysis of the human ubiquitin-related p roteome. (PubMed id 16196087)1 Matsumoto M....Nakayama K.I. (2005)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)
- Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. (PubMed id 12706105)1 Zhang Z. and Gerstein M. (2003)
|
External Searches for MRPS33 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPS33 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPS33 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPS33 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPS33 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRPS33 gene:
Search GeneIP for patents involving MRPS33
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPS33 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRPS33 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPS33 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS33 | | | OriGene Protein Over-expression Lysate for MRPS33 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRPS33 | | OriGene 3'-UTR Clone for MRPS33 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS33 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS33 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MRPS33 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MRPS33 | | OriGene Custom Protein Services for MRPS33 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPS33 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS33 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS33 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPS33 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS33 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS33 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MRPS33 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | MRPS33 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS33 |
|  |  |  | | | | ThermoFisher Antibody for MRPS33 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS33 |
|
|
|
|
