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Aliases for MRPS31 Gene

Aliases for MRPS31 Gene

  • Mitochondrial Ribosomal Protein S31 2 3
  • Imogen 38 3 4
  • IMOGN38 3 4
  • MRP-S31 3 4
  • S31mt 3 4
  • 28S Ribosomal Protein S31, Mitochondrial 3

External Ids for MRPS31 Gene

Previous GeneCards Identifiers for MRPS31 Gene

  • GC13M039289
  • GC13M035289
  • GC13M040240
  • GC13M039101
  • GC13M040201
  • GC13M041303
  • GC13M022104

Summaries for MRPS31 Gene

Entrez Gene Summary for MRPS31 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that has also been associated with type 1 diabetes; however, its relationship to the etiology of this disease remains to be clarified. Pseudogenes corresponding to this gene have been found on chromosomes 3 and 13. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS31 Gene

MRPS31 (Mitochondrial Ribosomal Protein S31) is a Protein Coding gene. GO annotations related to this gene include structural constituent of ribosome and protein domain specific binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS31 Gene

Genomics for MRPS31 Gene

Regulatory Elements for MRPS31 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPS31 Gene

40,729,135 bp from pter
40,771,211 bp from pter
42,077 bases
Minus strand

Genomic View for MRPS31 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS31 Gene

Proteins for MRPS31 Gene

  • Protein details for MRPS31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S31, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B2RCS3
    • Q5VYC8
    • Q8WTV8

    Protein attributes for MRPS31 Gene

    395 amino acids
    Molecular mass:
    45318 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins

neXtProt entry for MRPS31 Gene

Proteomics data for MRPS31 Gene at MOPED

Post-translational modifications for MRPS31 Gene

  • Ubiquitination at Lys174
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS31 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MRPS31 Gene

Domains for MRPS31 Gene

Gene Families for MRPS31 Gene

Protein Domains for MRPS31 Gene


Suggested Antigen Peptide Sequences for MRPS31 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPS31: view

No data available for UniProtKB/Swiss-Prot for MRPS31 Gene

Function for MRPS31 Gene

Gene Ontology (GO) - Molecular Function for MRPS31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 21988832
GO:0019904 protein domain specific binding IPI 11984006
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPS31: view

Animal Model Products

miRNA for MRPS31 Gene

miRTarBase miRNAs that target MRPS31

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS31

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS31 Gene

Localization for MRPS31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS31 Gene


Subcellular locations from

Jensen Localization Image for MRPS31 Gene COMPARTMENTS Subcellular localization image for MRPS31 gene
Compartment Confidence
mitochondrion 5
nucleus 3

Gene Ontology (GO) - Cellular Components for MRPS31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IEA --
genes like me logo Genes that share ontologies with MRPS31: view

Pathways for MRPS31 Gene

SuperPathways for MRPS31 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRPS31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS31: view

No data available for Pathways by source for MRPS31 Gene

Transcripts for MRPS31 Gene

mRNA/cDNA for MRPS31 Gene

Unigene Clusters for MRPS31 Gene

Mitochondrial ribosomal protein S31:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS31

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS31 Gene

No ASD Table

Relevant External Links for MRPS31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS31 Gene

mRNA expression in normal human tissues for MRPS31 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MRPS31 Gene

This gene is overexpressed in Lung (25.1) and Pancreas (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS31 Gene

SOURCE GeneReport for Unigene cluster for MRPS31 Gene Hs.596607

genes like me logo Genes that share expressions with MRPS31: view

Expression partners for MRPS31 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS31 Gene

Orthologs for MRPS31 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS31 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS31 35
  • 83.85 (n)
  • 76.56 (a)
MRPS31 36
  • 76 (a)
(Canis familiaris)
Mammalia MRPS31 35
  • 82.53 (n)
  • 74.3 (a)
MRPS31 36
  • 70 (a)
(Mus musculus)
Mammalia Mrps31 35
  • 77.46 (n)
  • 66.84 (a)
Mrps31 16
Mrps31 36
  • 67 (a)
(Pan troglodytes)
Mammalia MRPS31 35
  • 99.32 (n)
  • 98.99 (a)
MRPS31 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mrps31 35
  • 76.36 (n)
  • 66.49 (a)
(Monodelphis domestica)
Mammalia MRPS31 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS31 36
  • 58 (a)
(Gallus gallus)
Aves MRPS31 35
  • 63.23 (n)
  • 53.75 (a)
MRPS31 36
  • 47 (a)
(Anolis carolinensis)
Reptilia MRPS31 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps31 35
  • 58.28 (n)
  • 51.17 (a)
Str.15830 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7162 35
(Danio rerio)
Actinopterygii mrps31 35
  • 57.59 (n)
  • 53.1 (a)
mrps31 36
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS31 37
  • 35 (a)
mRpS31 36
  • 26 (a)
(Caenorhabditis elegans)
Secernentea mrps-31 36
  • 22 (a)
Species with no ortholog for MRPS31:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS31 Gene

Gene Tree for MRPS31 (if available)
Gene Tree for MRPS31 (if available)

Paralogs for MRPS31 Gene Pseudogenes for MRPS31 Gene

genes like me logo Genes that share paralogs with MRPS31: view

No data available for Paralogs for MRPS31 Gene

Variants for MRPS31 Gene

Sequence variations from dbSNP and Humsavar for MRPS31 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs76080821 -- 40,770,068(+) GCTCC(A/G)CATTC intron-variant
rs75933645 -- 40,738,951(+) GGCAG(G/T)AGAAA intron-variant
rs75924449 -- 40,760,751(+) CCAAC(C/T)GCCAC intron-variant
rs75715054 -- 40,770,116(+) AGCCA(A/G)TTGAA intron-variant
rs75686251 -- 40,768,386(+) TGACC(C/T)CCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS31 Gene

Variant ID Type Subtype PubMed ID
nsv900010 CNV Loss 21882294
nsv900011 CNV Loss 21882294
esv2747292 CNV Deletion 23290073
esv2747293 CNV Deletion 23290073

Relevant External Links for MRPS31 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS31 Gene

Disorders for MRPS31 Gene

Relevant External Links for MRPS31

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MRPS31 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MRPS31 Gene

Publications for MRPS31 Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4
  2. Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient. (PMID: 8567980) Arden S.D. … Hutton J.C. (J. Clin. Invest. 1996) 2 4
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for MRPS31 Gene

Sources for MRPS31 Gene

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