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Aliases for MRPS30 Gene

Aliases for MRPS30 Gene

  • Mitochondrial Ribosomal Protein S30 2 3
  • MRP-S30 3 4
  • PDCD9 3 4
  • S30mt 3 4
  • 28S Ribosomal Protein S30, Mitochondrial 3
  • Programmed Cell Death Protein 9 4
  • Programmed Cell Death 9 3
  • PAP 3

External Ids for MRPS30 Gene

Previous HGNC Symbols for MRPS30 Gene

  • PDCD9

Previous GeneCards Identifiers for MRPS30 Gene

  • GC05P045118
  • GC05P045985
  • GC05P044809
  • GC05P044854
  • GC05P044844

Summaries for MRPS30 Gene

Entrez Gene Summary for MRPS30 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS30 Gene

MRPS30 (Mitochondrial Ribosomal Protein S30) is a Protein Coding gene. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS30 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS30 Gene

Genomics for MRPS30 Gene

Regulatory Elements for MRPS30 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPS30 Gene

44,808,925 bp from pter
44,820,428 bp from pter
11,504 bases
Plus strand

Genomic View for MRPS30 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS30 Gene

Proteins for MRPS30 Gene

  • Protein details for MRPS30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S30, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q96I91
    • Q96Q19
    • Q9H0P8
    • Q9NSF9
    • Q9NZ76

    Protein attributes for MRPS30 Gene

    439 amino acids
    Molecular mass:
    50365 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins
    • Sequence=AAF67634.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAF67634.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS30 Gene

neXtProt entry for MRPS30 Gene

Proteomics data for MRPS30 Gene at MOPED

Post-translational modifications for MRPS30 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS30 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MRPS30 Gene

Domains for MRPS30 Gene

Gene Families for MRPS30 Gene

Protein Domains for MRPS30 Gene


Suggested Antigen Peptide Sequences for MRPS30 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S30/L37 family.
  • Belongs to the ribosomal protein S30/L37 family.
genes like me logo Genes that share domains with MRPS30: view

Function for MRPS30 Gene

Gene Ontology (GO) - Molecular Function for MRPS30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPS30: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS30

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRPS30 Gene

Localization for MRPS30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS30 Gene


Subcellular locations from

Jensen Localization Image for MRPS30 Gene COMPARTMENTS Subcellular localization image for MRPS30 gene
Compartment Confidence
mitochondrion 5
cytosol 3
nucleus 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for MRPS30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS30: view

Pathways for MRPS30 Gene

SuperPathways for MRPS30 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRPS30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation --
GO:0006915 apoptotic process TAS 10640817
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPS30: view

No data available for Pathways by source for MRPS30 Gene

Transcripts for MRPS30 Gene

Unigene Clusters for MRPS30 Gene

Mitochondrial ribosomal protein S30:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS30

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS30 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP3: -

Relevant External Links for MRPS30 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS30 Gene

mRNA expression in normal human tissues for MRPS30 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MRPS30 Gene

This gene is overexpressed in Lung (21.6), Breast (20.6), and Pancreas (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS30 Gene

SOURCE GeneReport for Unigene cluster for MRPS30 Gene Hs.124165

mRNA Expression by UniProt/SwissProt for MRPS30 Gene

Tissue specificity: Heart, skeletal muscle, kidney and liver. Lower expression in placenta and peripheral blood leukocytes.
genes like me logo Genes that share expressions with MRPS30: view

Expression partners for MRPS30 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MRPS30 Gene

Orthologs for MRPS30 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS30 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS30 35
  • 83.83 (n)
  • 81.15 (a)
MRPS30 36
  • 81 (a)
(Canis familiaris)
Mammalia MRPS30 35
  • 84.95 (n)
  • 81.94 (a)
MRPS30 36
  • 82 (a)
(Mus musculus)
Mammalia Mrps30 35
  • 80.14 (n)
  • 74.6 (a)
Mrps30 16
Mrps30 36
  • 73 (a)
(Pan troglodytes)
Mammalia MRPS30 35
  • 99.7 (n)
  • 99.77 (a)
MRPS30 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrps30 35
  • 80.12 (n)
  • 74.71 (a)
(Monodelphis domestica)
Mammalia MRPS30 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS30 36
  • 77 (a)
(Gallus gallus)
Aves MRPS30 35
  • 68.12 (n)
  • 61.59 (a)
MRPS30 36
  • 54 (a)
(Anolis carolinensis)
Reptilia MRPS30 36
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps30 35
  • 62.25 (n)
  • 58.44 (a)
Str.8199 35
African clawed frog
(Xenopus laevis)
Amphibia PDCD9 35
(Danio rerio)
Actinopterygii Dr.5260 35
mrps30 35
  • 57.68 (n)
  • 52.16 (a)
mrps30 36
  • 50 (a)
MRPS30 (1 of 2) 36
  • 42 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13753 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001134 35
  • 41.56 (n)
  • 32.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS30 35
  • 40.97 (n)
  • 29.11 (a)
mRpS30 36
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2384 36
  • 25 (a)
Species with no ortholog for MRPS30:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS30 Gene

Gene Tree for MRPS30 (if available)
Gene Tree for MRPS30 (if available)

Paralogs for MRPS30 Gene

No data available for Paralogs for MRPS30 Gene

Variants for MRPS30 Gene

Sequence variations from dbSNP and Humsavar for MRPS30 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs376396555 -- 44,815,092(+) ATGAA(A/G)CAATT reference, missense
rs375996054 -- 44,811,169(+) TATTG(C/T)GATTA intron-variant
rs375243025 -- 44,814,807(+) AAAGT(A/G)TCTAA intron-variant
rs374868414 -- 44,811,035(+) TTTAC(C/T)GGGTG missense, reference
rs374757543 -- 44,814,902(+) TAACT(G/T)TCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS30 Gene

Variant ID Type Subtype PubMed ID
nsv830279 CNV Gain 17160897
nsv880712 CNV Loss 21882294
dgv6044n71 CNV Loss 21882294
dgv6045n71 CNV Loss 21882294
nsv881280 CNV Loss 21882294
nsv881418 CNV Loss 21882294
nsv462127 CNV Loss 19166990
dgv6046n71 CNV Loss 21882294

Relevant External Links for MRPS30 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS30 Gene

Disorders for MRPS30 Gene

Relevant External Links for MRPS30

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MRPS30 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MRPS30 Gene

Publications for MRPS30 Gene

  1. Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52. (PMID: 10640817) Carim-Todd L. … Escarceller M. (Cytogenet. Cell Genet. 1999) 2 3 4 23
  2. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4
  3. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 3 4
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for MRPS30 Gene

Sources for MRPS30 Gene

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