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MRPS30 Gene

protein-coding   GIFtS: 50
GCID: GC05P044809

Mitochondrial Ribosomal Protein S30


(Previous symbol: PDCD9)
  See MRPS30-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Ribosomal Protein S301 2     28S Ribosomal Protein S30, Mitochondrial2
PDCD91 2 3     PAP2
MRP-S302 3     Programmed Cell Death 92
S30mt2 3     Programmed Cell Death Protein 93

External Ids:    HGNC: 87691   Entrez Gene: 108842   Ensembl: ENSG000001129967   OMIM: 6119915   UniProtKB: Q9NP923   

Export aliases for MRPS30 gene to outside databases

Previous GC identifers: GC05P045118 GC05P045985 GC05P044854 GC05P044844


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRPS30 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using
alternative promoters or polyA sites have been mentioned in the literature but the complete description of these
sequences is not available. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPS30 Gene:
MRPS30 (mitochondrial ribosomal protein S30) is a protein-coding gene. Diseases associated with MRPS30 include breast cancer susceptibility. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS30 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRPS30 gene promoter:
         NRSF form 1   NRSF form 2   C/EBPalpha   MZF-1   POU2F1   E2F   E2F-1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MRPS30 promoter sequence
   Search Chromatin IP Primers for MRPS30

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRPS30


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q11   Ensembl cytogenetic band:  5p12   HGNC cytogenetic band: 5q11

MRPS30 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPS30 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P044809:  view genomic region     (about GC identifiers)

Start:
44,809,027 bp from pter      End:
44,820,530 bp from pter
Size:
11,504 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RT30_HUMAN, Q9NP92 (See protein sequence)
Recommended Name: 28S ribosomal protein S30, mitochondrial  
Size: 439 amino acids; 50365 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30
distinct proteins
Sequence caution: Sequence=AAF67634.1; Type=Frameshift; Positions=Several; Sequence=AAF67634.1; Type=Miscellaneous
discrepancy; Note=Sequencing errors;
Secondary accessions: Q96I91 Q96Q19 Q9H0P8 Q9NSF9 Q9NZ76

Explore the universe of human proteins at neXtProt for MRPS30: NX_Q9NP92

Explore proteomics data for MRPS30 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MRPS30 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057724.2  
    ENSEMBL proteins: 
     ENSP00000424328  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MRPS: Mitochondrial ribosomal proteins / small subunits

    1 InterPro protein domain:
     IPR010793 Ribosomal_L37/S30

    Graphical View of Domain Structure for InterPro Entry Q9NP92

    ProtoNet protein and cluster: Q9NP92

    UniProtKB/Swiss-Prot: RT30_HUMAN, Q9NP92
    Similarity: Belongs to the ribosomal protein S30/L37 family


    Find genes that share domains with MRPS30           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with MRPS30           About GenesLikeMe


    Animal Models:
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    3 qRT-PCR Assays for microRNAs that regulate MRPS30:
    hsa-miR-616* hsa-miR-944 hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidMRPS30 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RT30_HUMAN, Q9NP92: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol3
    nucleus3
    peroxisome2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005840ribosome IEA--

    Find genes that share ontologies with MRPS30           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRPS30
    Interactions:

        Search GeneGlobe Interaction Network for MRPS30

    Selected Interacting proteins for MRPS30 (Q9NP922, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 244)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3MINT-8079030 I2D: score=1 
    MAGEA11P433643I2D: score=1 
    AARS2Q5JTZ92MINT-8079030
    AASSQ9UDR52MINT-8079030
    ABCB7O750272MINT-8079030
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation IEA--
    GO:0006915apoptotic process TAS10640817

    Find genes that share ontologies with MRPS30           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRPS30 (RT30)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MRPS30 gene: 
    NM_016640.3  

    Unigene Cluster for MRPS30:

    Mitochondrial ribosomal protein S30
    Hs.124165  [show with all ESTs]
    Unigene Representative Sequence: NM_016640
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000507110(uc003joh.3) ENST00000515647(uc003joi.1) ENST00000508129
    ENST00000230914
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate MRPS30:
    hsa-miR-616* hsa-miR-944 hsa-miR-373*
    SwitchGear 3'UTR luciferase reporter plasmidMRPS30 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat MRPS30
      QuantiFast Probe-based Assays in human, mouse, rat MRPS30

    Additional mRNA sequence: 

    AF146192.2 AF217523.1 AK074777.1 AK222704.1 AK222894.1 AL136706.1 AL355715.1 AL355716.1 
    AL355718.1 BC002460.2 BC007735.2 

    4 DOTS entries:

    DT.443001  DT.100782208  DT.91764081  DT.100709167 

    Selected AceView cDNA sequences (see all 223):

    BU624519 AW769869 AA535081 CA446970 BF817110 BI494731 BF591472 BM681485 
    BM726700 BI335010 CR601124 BX096305 BX115772 CD674935 AI039322 Z39368 
    CA428387 AA412482 AL355716 BM971487 BI826730 AA282920 BC002460 AA814781 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS30    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
    SP1:                    -                                       
    SP2:                                                            
    SP3:                    -                                       


    ECgene alternative splicing isoforms for MRPS30

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRPS30 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTACCCGC
    MRPS30 Expression
    About this image


    MRPS30 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    MRPS30 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRPS30 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.124165

    UniProtKB/Swiss-Prot: RT30_HUMAN, Q9NP92
    Tissue specificity: Heart, skeletal muscle, kidney and liver. Lower expression in placenta and peripheral blood
    leukocytes

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MRPS30 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrps301 , 5 mitochondrial ribosomal protein S301, 5 80.14(n)1
    74.6(a)1
      13 (66.88 cM)5
    590541  NM_021556.31  NP_067531.11 
     1183801105 
    chicken
    (Gallus gallus)
    Aves MRPS301 mitochondrial ribosomal protein S30 68.12(n)
    61.59(a)
      395781  NM_204939.1  NP_990270.1 
    lizard
    (Anolis carolinensis)
    Reptilia MRPS306
    mitochondrial ribosomal protein S30
    62(a)
    1 ↔ 1
    2(5475811-5483253)
    African clawed frog
    (Xenopus laevis)
    Amphibia PDCD92 PDCD9 protein 76.8(n)    AF317657.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.52602 Transcribed sequence with weak similarity to protein more 76.64(n)    57050817 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpS301 mitochondrial ribosomal protein S30 40.97(n)
    29.11(a)
      32530  NM_078612.3  NP_511167.1 


    ENSEMBL Gene Tree for MRPS30 (if available)
    TreeFam Gene Tree for MRPS30 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MRPS30 (see all 117)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1922685801,2
    --44810992(+) CCAGAC/TTCTTA 1 -- int10--------
    rs727562071,2
    C,F--44811207(+) CCAGAT/GAGATG 2 /R /I mis11Minor allele frequency- G:0.00NA 4548
    rs2009672721,2
    --44811218(+) ATAAAC/TCAAAC 2 P S mis10--------
    rs1431161271,2
    C,F--44811241(+) ATATCC/TAAGCA 2 S syn11Minor allele frequency- T:0.00NA 4548
    rs2022017441,2
    --44811268(+) ATTTAC/TTGCGA 1 -- int10--------
    rs1489503411,2
    C--44811291(+) TGATAC/TCTCGT 1 -- int10--------
    rs1865917191,2
    --44811356(+) AGGTGA/GATCTC 1 -- int10--------
    rs358507601,2
    C,F--44811508(+) GATCTA/GTATGT 1 -- int16Minor allele frequency- G:0.06NA WA 246
    rs1895697171,2
    --44811763(+) TGTTGC/TAAGTG 1 -- int10--------
    rs1437777001,2
    --44811796(+) CAAAGC/TGCCAT 1 -- int10--------

    HapMap Linkage Disequilibrium report for MRPS30 (44809027 - 44820530 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for MRPS30:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv6045n71CNV Loss21882294
    nsv462127CNV Loss19166990
    dgv6044n71CNV Loss21882294
    nsv881280CNV Loss21882294
    nsv881418CNV Loss21882294
    dgv6046n71CNV Loss21882294
    nsv880712CNV Loss21882294
    nsv830279CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRPS30
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPS30

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611991    OMIM disorders: --

    1 disease for MRPS30:    
    About MalaCards
    breast cancer susceptibility


    Find genes that share disorders with MRPS30           About GenesLikeMe

    Genetic Association Database (GAD): MRPS30
    Human Genome Epidemiology (HuGE) Navigator: MRPS30 (6 documents)

    Export disorders for MRPS30 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRPS30 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with MRPS30)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52. (PubMed id 10640817)1, 2, 3, 9 Carim-Todd L.... Escarceller M. (Cytogenet. Cell Genet. 1999)
    2. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2, 3 Koc E.C.... Spremulli L.L. (J. Biol. Chem. 2001)
    3. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. Evaluation of 11 breast cancer susceptibility loci in African-American women. (PubMed id 19789366)1, 4 Zheng W....Blot W.J. (amp 2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2 Kenmochi N.... Tanaka T. (Genomics 2001)
    10. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10884 HGNC: 8769 AceView: MRPS30 Ensembl:ENSG00000112996 euGenes: HUgn10884
    ECgene: MRPS30 H-InvDB: MRPS30

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRPS30 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MRPS30 gene:
    Search GeneIP for patents involving MRPS30

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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