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Aliases for MRPS30 Gene

Aliases for MRPS30 Gene

  • Mitochondrial Ribosomal Protein S30 2 3
  • MRP-S30 3 4
  • PDCD9 3 4
  • S30mt 3 4
  • 28S Ribosomal Protein S30, Mitochondrial 3
  • Programmed Cell Death Protein 9 4
  • Programmed Cell Death 9 3
  • PAP 3

External Ids for MRPS30 Gene

Previous Symbols for MRPS30 Gene

  • PDCD9

Summaries for MRPS30 Gene

Entrez Gene Summary for MRPS30 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS30 Gene

MRPS30 (Mitochondrial Ribosomal Protein S30) is a Protein Coding gene. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS30 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS30 Gene

Genomics for MRPS30 Gene

Genomic Location for MRPS30 Gene

Start:
44,808,925 bp from pter
End:
44,820,428 bp from pter
Size:
11,504 bases
Orientation:
Plus strand

Genomic View for MRPS30 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS30 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS30 Gene

Regulatory Elements for MRPS30 Gene

Proteins for MRPS30 Gene

  • Protein details for MRPS30 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NP92-RT30_HUMAN
    Recommended name:
    28S ribosomal protein S30, mitochondrial
    Protein Accession:
    Q9NP92
    Secondary Accessions:
    • Q96I91
    • Q96Q19
    • Q9H0P8
    • Q9NSF9
    • Q9NZ76

    Protein attributes for MRPS30 Gene

    Size:
    439 amino acids
    Molecular mass:
    50365 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins
    SequenceCaution:
    • Sequence=AAF67634.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAF67634.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS30 Gene

neXtProt entry for MRPS30 Gene

Proteomics data for MRPS30 Gene at MOPED

Post-translational modifications for MRPS30 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS30 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS30 Gene

Domains for MRPS30 Gene

Gene Families for MRPS30 Gene

HGNC:
  • MRPS :Mitochondrial ribosomal proteins / small subunits

Protein Domains for MRPS30 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

RT30_HUMAN
Family:
  • Belongs to the ribosomal protein S30/L37 family.:
    • Q9NP92
genes like me logo Genes that share domains with MRPS30: view

Function for MRPS30 Gene

Gene Ontology (GO) - Molecular Function for MRPS30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPS30: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MRPS30 Gene

Localization for MRPS30 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS30 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS30 Gene COMPARTMENTS Subcellular localization image for MRPS30 gene
Compartment Confidence
mitochondrion 5
cytosol 3
nucleus 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for MRPS30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS30: view

Pathways for MRPS30 Gene

SuperPathways for MRPS30 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRPS30 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation --
GO:0006915 apoptotic process TAS 10640817
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPS30: view

No data available for Pathways by source for MRPS30 Gene

Transcripts for MRPS30 Gene

Unigene Clusters for MRPS30 Gene

Mitochondrial ribosomal protein S30:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS30 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2:
SP3: -

Relevant External Links for MRPS30 Gene

GeneLoc Exon Structure for
MRPS30
ECgene alternative splicing isoforms for
MRPS30

Expression for MRPS30 Gene

mRNA expression in normal human tissues for MRPS30 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS30 Gene

SOURCE GeneReport for Unigene cluster for MRPS30 Gene Hs.124165

mRNA Expression by UniProt/SwissProt for MRPS30 Gene

Q9NP92-RT30_HUMAN
Tissue specificity: Heart, skeletal muscle, kidney and liver. Lower expression in placenta and peripheral blood leukocytes.
genes like me logo Genes that share expressions with MRPS30: view

Orthologs for MRPS30 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS30 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS30 36
  • 99.7 (n)
  • 99.77 (a)
MRPS30 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPS30 36
  • 83.83 (n)
  • 81.15 (a)
MRPS30 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS30 36
  • 84.95 (n)
  • 81.94 (a)
MRPS30 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrps30 36
  • 80.14 (n)
  • 74.6 (a)
Mrps30 16
Mrps30 37
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPS30 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS30 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps30 36
  • 80.12 (n)
  • 74.71 (a)
chicken
(Gallus gallus)
Aves MRPS30 36
  • 68.12 (n)
  • 61.59 (a)
MRPS30 37
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPS30 37
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia PDCD9 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps30 36
  • 62.25 (n)
  • 58.44 (a)
Str.8199 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13753 36
zebrafish
(Danio rerio)
Actinopterygii Dr.5260 36
mrps30 36
  • 57.68 (n)
  • 52.16 (a)
mrps30 37
  • 50 (a)
OneToMany
MRPS30 (1 of 2) 37
  • 42 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001134 36
  • 41.56 (n)
  • 32.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS30 36
  • 40.97 (n)
  • 29.11 (a)
mRpS30 37
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2384 37
  • 25 (a)
OneToOne
Species with no ortholog for MRPS30:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS30 Gene

ENSEMBL:
Gene Tree for MRPS30 (if available)
TreeFam:
Gene Tree for MRPS30 (if available)

Paralogs for MRPS30 Gene

No data available for Paralogs for MRPS30 Gene

Variants for MRPS30 Gene

Sequence variations from dbSNP and Humsavar for MRPS30 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs3062459 -- 44,815,967(+) AAAGA(-/AAAGA)TAGAT downstream-variant-500B
rs7737306 -- 44,813,216(+) TAGAA(A/G)TTGTT missense, reference
rs10076253 -- 44,815,230(+) TGTGG(A/G)AATAT utr-variant-3-prime
rs10077694 -- 44,812,256(+) AACTT(C/T)AGAAA intron-variant
rs11741772 -- 44,814,495(+) AAATT(A/C)CATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS30 Gene

Variant ID Type Subtype PubMed ID
nsv830279 CNV Gain 17160897
nsv880712 CNV Loss 21882294
dgv6044n71 CNV Loss 21882294
dgv6045n71 CNV Loss 21882294
nsv881280 CNV Loss 21882294
nsv881418 CNV Loss 21882294
nsv462127 CNV Loss 19166990
dgv6046n71 CNV Loss 21882294

Relevant External Links for MRPS30 Gene

HapMap Linkage Disequilibrium report
MRPS30

Disorders for MRPS30 Gene

Relevant External Links for MRPS30

Genetic Association Database (GAD)
MRPS30
Human Genome Epidemiology (HuGE) Navigator
MRPS30
genes like me logo Genes that share disorders with MRPS30: view

No data available for UniProtKB/Swiss-Prot for MRPS30 Gene

Publications for MRPS30 Gene

  1. Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52. (PMID: 10640817) Carim-Todd L. … Escarceller M. (Cytogenet. Cell Genet. 1999) 2 3 4 23
  2. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4
  3. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MRPS30 Gene

  • antibodies-online proteins for MRPS30
  • antibodies-online antibodies for MRPS30
  • antibodies-online kits for MRPS30

Sources for MRPS30 Gene

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