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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRPS28 Gene

protein-coding   GIFtS: 51
GCID: GC08M080830

Mitochondrial Ribosomal Protein S28

  Search for MRPS28
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrial Ribosomal Protein S281 2     S28mt2 3
MRPS352 3 5     S35mt2 3
28S Ribosomal Protein S35, Mitochondrial2 3     28S Ribosomal Protein S28, Mitochondrial2
MRP-S282 3     Mitochondrial 28S Ribosomal Protein S352
MRP-S352 3     

External Ids:    HGNC: 145131   Entrez Gene: 289572   Ensembl: ENSG000001475867   OMIM: 6119905   UniProtKB: Q9Y2Q93   

Export aliases for MRPS28 gene to outside databases

Previous GC identifers: GC08M079718 GC08M080879 GC08M080554 GC08M080881 GC08M080993 GC08M076320


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRPS28 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature. (provided by
RefSeq, Jul 2008)

GeneCards Summary for MRPS28 Gene: 
MRPS28 (mitochondrial ribosomal protein S28) is a protein-coding gene. GO annotations related to this gene include molecular_function.

Gene Wiki entry for MRPS28 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008183.19  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRPS28 gene promoter:
         POU2F1   ATF-2   POU2F1a   POU2F1b   POU2F1c   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPS28 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRPS28

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.1-q21.2   Ensembl cytogenetic band:  8q21.13   HGNC cytogenetic band: 8q21.1-q21.2

MRPS28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPS28 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M080830:  view genomic region     (about GC identifiers)

Start:
80,830,952 bp from pter      End:
80,942,524 bp from pter
Size:
111,573 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RT28_HUMAN, Q9Y2Q9 (See protein sequence)
Recommended Name: 28S ribosomal protein S28, mitochondrial precursor  
Size: 187 amino acids; 20843 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30
distinct proteins
Subcellular location: Mitochondrion
Secondary accessions: B2RDZ7 Q96Q21

Explore the universe of human proteins at neXtProt for MRPS28: NX_Q9Y2Q9

Explore proteomics data for MRPS28 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2Q9

  • MRPS28 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MRPS28 Protein Expression
    REFSEQ proteins: NP_054737.1  
    ENSEMBL proteins: 
     ENSP00000276585   ENSP00000430858   ENSP00000428050   ENSP00000428880   ENSP00000427965  
     ENSP00000428744   ENSP00000430401   ENSP00000427846   ENSP00000476135  

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    Novus Biologicals MRPS28 Lysates
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    Cloud-Clone Corp. Proteins for MRPS28 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005763mitochondrial small ribosomal subunit TAS10938081

    MRPS28 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MRPS: Mitochondrial ribosomal proteins / small subunits

    2 InterPro protein domains:
     IPR019375 Ribosomal_S28_mit
     IPR022967 RNA-binding_domain_S1

    Graphical View of Domain Structure for InterPro Entry Q9Y2Q9

    ProtoNet protein and cluster: Q9Y2Q9

    1 Blocks protein domain: IPB003029 RNA binding S1


    MRPS28 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    MRPS28 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for MRPS28:
     High actin ratio cells  Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MRPS28 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS28

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/250 Interacting proteins for MRPS28 (Q9Y2Q92, 3 ENSP000002765854) via UniProtKB, MINT, STRING, and/or I2D (see all 250)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    SQSTM1Q135013I2D: score=1 
    AARS2Q5JTZ92MINT-8079030
    AASSQ9UDR52MINT-8079030
    ABCB7O750272MINT-8079030
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    MRPS28 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRPS28 (RT28)

    Search CenterWatch for drugs/clinical trials and news about MRPS28 / RT28

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRPS28 gene: 
    NM_014018.2  

    Unigene Cluster for MRPS28:

    Mitochondrial ribosomal protein S28
    Hs.521124  [show with all ESTs]
    Unigene Representative Sequence: BM918955
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000276585(uc003ybp.3) ENST00000522938 ENST00000519386 ENST00000521434
    ENST00000521605 ENST00000519120 ENST00000520946 ENST00000518271 ENST00000518371
    ENST00000522987
    miRNA
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    Additional mRNA sequence: 

    AF070663.1 AK026506.1 AK223069.1 AK315739.1 BC010150.1 

    12 DOTS entries:

    DT.97861889  DT.95269386  DT.92433443  DT.446843  DT.97861890  DT.416197  DT.416198  DT.100813049 
    DT.100813050  DT.120643319  DT.92433445  DT.92010984 

    24/159 AceView cDNA sequences (see all 159):

    AA825586 BM681572 BM840971 AA971612 BQ013033 AA808142 AA844635 BQ675864 
    BM841023 BM726401 BX398585 BQ212488 CA414890 AA010860 CR602923 AI000133 
    BC010150 N95051 AA932612 AA846234 BQ420707 NM_014018 AA860736 AI253698 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS28    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
    SP1:              -     -                 -                           
    SP2:                    -                 -                           
    SP3:                                      -                           
    SP4:              -     -     -     -     -                           
    SP5:                                                                  


    ECgene alternative splicing isoforms for MRPS28

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRPS28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAATAAAT
    MRPS28 Expression
    About this image


    See MRPS28 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRPS28

    SOURCE GeneReport for Unigene cluster: Hs.521124
        SABiosciences Custom PCR Arrays for MRPS28
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MRPS28 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrps281 , 5 mitochondrial ribosomal protein S281, 5 76.52(n)1
    73.66(a)1
      3 (2.17 cM)5
    662301  NM_025434.31  NP_079710.31 
     88021465 
    chicken
    (Gallus gallus)
    Aves MRPS281 mitochondrial ribosomal protein S28 71.01(n)
    80(a)
      770322  XM_001233657.2  XP_001233658.2 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.14312 Transcribed sequence with weak similarity to protein more 72.52(n)    AL775404.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.148252 Transcribed sequence with weak similarity to protein more 68.01(n)    BM958205.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpS281 mitochondrial ribosomal protein S28 52.78(n)
    43.75(a)
      37136  NM_079061.3  NP_523785.2 
    worm
    (Caenorhabditis elegans)
    Secernentea mrps-286
    Protein MRPS-28
    33(a)
    1 ↔ 1
    V(19644239-19645758)


    ENSEMBL Gene Tree for MRPS28 (if available)
    TreeFam Gene Tree for MRPS28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRPS28 gene
    5 SIMAP similar genes for MRPS28 using alignment to 8 protein entries:     RT28_HUMAN (see all proteins):
    TPD52    L3MBTL2    TMEM106B    ADCY7    RHBDD3

    MRPS28 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2073 SNPs in MRPS28 are shown (see all 2073)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1414606981,2
    --80830611(+) GCCTCC/TCTCAC 1 -- ds50010--------
    rs799733411,2
    C,F--80830737(+) GAAAAC/TTCTTC 1 -- ds50011Minor allele frequency- T:0.07WA 118
    rs770811391,2
    C--80830831(+) ATCACT/CGTCTA 1 -- ds50012Minor allele frequency- C:0.05CSA WA 120
    rs126824531,2
    C,F,A,H--80830921(+) ATTTGG/TTTACT 1 -- ds500116Minor allele frequency- T:0.31NS EA NA WA CSA 796
    rs1843232551,2
    --80830961(+) CAGCAC/TTCAAA 1 -- ds50010--------
    rs1508621511,2
    --80830968(+) CAAAAC/TGTATT 1 -- ds50010--------
    rs1156066201,2
    C,F--80830983(+) GAATGA/GCAATT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs1167738911,2
    C,F--80830984(+) AATGAC/GAATTT 1 -- ds50011Minor allele frequency- G:0.03WA 118
    rs590382231,2
    C,F--80831020(+) CCAAAG/AGAAAA 1 -- ds50011Minor allele frequency- A:0.50WA 2
    rs1892718161,2
    C--80831050(+) AGGGGC/TGGGGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MRPS28 (80830952 - 80942524 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MRPS28:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2666906CNV Deletion23128226
    nsv891061CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MRPS28 for disorders           About MalaCards
    OMIM gene information: 611990    OMIM disorders: --


    MRPS28 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRPS28
    Human Genome Epidemiology (HuGE) Navigator: MRPS28 (1 document)

    Export disorders for MRPS28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRPS28 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with MRPS28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2 Kenmochi N....Tanaka T. (2001)
    5. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 3 Koc E.C.... Spremulli L.L. (2001)
    6. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. (PubMed id 10938081)1, 2 Koc E.C....Spremulli L.L. (2000)
    7. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    8. p32/gC1qR is indispensable for fetal development and m itochondrial translation: importance of its RNA-binding ability. (PubMed id 22904065)1 Yagi M....Kang D. (2012)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28957 HGNC: 14513 AceView: MRPS28 Ensembl:ENSG00000147586 euGenes: HUgn28957
    ECgene: MRPS28 H-InvDB: MRPS28

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRPS28 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRPS28 gene:
    Search GeneIP for patents involving MRPS28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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