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Aliases for MRPS28 Gene

Aliases for MRPS28 Gene

  • Mitochondrial Ribosomal Protein S28 2 3
  • MRPS35 3 4 6
  • 28S Ribosomal Protein S35, Mitochondrial 3 4
  • MRP-S28 3 4
  • MRP-S35 3 4
  • S28mt 3 4
  • S35mt 3 4
  • 28S Ribosomal Protein S28, Mitochondrial 3
  • Mitochondrial 28S Ribosomal Protein S35 3
  • HSPC007 3

External Ids for MRPS28 Gene

Summaries for MRPS28 Gene

Entrez Gene Summary for MRPS28 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS28 Gene

MRPS28 (Mitochondrial Ribosomal Protein S28) is a Protein Coding gene.

Gene Wiki entry for MRPS28 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS28 Gene

Genomics for MRPS28 Gene

Genomic Location for MRPS28 Gene

Start:
79,918,717 bp from pter
End:
80,030,289 bp from pter
Size:
111,573 bases
Orientation:
Minus strand

Genomic View for MRPS28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS28 Gene

Regulatory Elements for MRPS28 Gene

Proteins for MRPS28 Gene

  • Protein details for MRPS28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2Q9-RT28_HUMAN
    Recommended name:
    28S ribosomal protein S28, mitochondrial
    Protein Accession:
    Q9Y2Q9
    Secondary Accessions:
    • B2RDZ7
    • Q96Q21

    Protein attributes for MRPS28 Gene

    Size:
    187 amino acids
    Molecular mass:
    20843 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins

neXtProt entry for MRPS28 Gene

Proteomics data for MRPS28 Gene at MOPED

Post-translational modifications for MRPS28 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys75

No data available for DME Specific Peptides for MRPS28 Gene

Domains for MRPS28 Gene

Gene Families for MRPS28 Gene

HGNC:
  • MRPS :Mitochondrial ribosomal proteins / small subunits

Protein Domains for MRPS28 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPS28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPS28: view

No data available for UniProtKB/Swiss-Prot for MRPS28 Gene

Function for MRPS28 Gene

Gene Ontology (GO) - Molecular Function for MRPS28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPS28: view

Phenotypes for MRPS28 Gene

genes like me logo Genes that share phenotypes with MRPS28: view

miRNA for MRPS28 Gene

miRTarBase miRNAs that target MRPS28

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPS28 Gene

Localization for MRPS28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS28 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS28 Gene COMPARTMENTS Subcellular localization image for MRPS28 gene
Compartment Confidence
mitochondrion 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPS28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit TAS 10938081
genes like me logo Genes that share ontologies with MRPS28: view

Pathways for MRPS28 Gene

SuperPathways for MRPS28 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRPS28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0008150 biological_process ND --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPS28: view

No data available for Pathways by source for MRPS28 Gene

Transcripts for MRPS28 Gene

Unigene Clusters for MRPS28 Gene

Mitochondrial ribosomal protein S28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS28 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - - -
SP2: - -
SP3: -
SP4: - - - - -
SP5:

Relevant External Links for MRPS28 Gene

GeneLoc Exon Structure for
MRPS28
ECgene alternative splicing isoforms for
MRPS28

Expression for MRPS28 Gene

mRNA expression in normal human tissues for MRPS28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MRPS28 Gene

SOURCE GeneReport for Unigene cluster for MRPS28 Gene Hs.521124

genes like me logo Genes that share expressions with MRPS28: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS28 Gene

Orthologs for MRPS28 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS28 35
  • 98.22 (n)
  • 97.33 (a)
MRPS28 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPS28 35
  • 86.56 (n)
  • 85.48 (a)
MRPS28 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS28 35
  • 84.59 (n)
  • 81.72 (a)
MRPS28 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrps28 35
  • 76.52 (n)
  • 73.66 (a)
Mrps28 16
Mrps28 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPS28 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100124857 35
  • 64.5 (n)
  • 70.73 (a)
Str.1431 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4190 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14825 35
mrps28 35
  • 56.59 (n)
  • 55.23 (a)
mrps28 36
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006650 35
  • 54.74 (n)
  • 54.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS28 35
  • 54.14 (n)
  • 46.62 (a)
mRpS28 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrps-28 36
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToOne
Species with no ortholog for MRPS28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS28 Gene

ENSEMBL:
Gene Tree for MRPS28 (if available)
TreeFam:
Gene Tree for MRPS28 (if available)

Paralogs for MRPS28 Gene

genes like me logo Genes that share paralogs with MRPS28: view

No data available for Paralogs for MRPS28 Gene

Variants for MRPS28 Gene

Sequence variations from dbSNP and Humsavar for MRPS28 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs441958 -- 79,972,416(-) caaaa(G/T)gtgga intron-variant
rs720302 -- 79,941,339(-) GAAGA(A/G)TAGCA intron-variant
rs964058 -- 79,973,341(-) ACTGC(A/T)CTCCA intron-variant
rs1008122 -- 79,989,289(-) CTGAT(C/T)CAAGC intron-variant
rs1057894 -- 79,956,322(-) CTACC(A/G)GATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS28 Gene

Variant ID Type Subtype PubMed ID
esv2666906 CNV Deletion 23128226
nsv891061 CNV Loss 21882294

Relevant External Links for MRPS28 Gene

HapMap Linkage Disequilibrium report
MRPS28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS28 Gene

Disorders for MRPS28 Gene

Relevant External Links for MRPS28

Genetic Association Database (GAD)
MRPS28
Human Genome Epidemiology (HuGE) Navigator
MRPS28
genes like me logo Genes that share disorders with MRPS28: view

No data available for UniProtKB/Swiss-Prot for MRPS28 Gene

Publications for MRPS28 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3
  3. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for MRPS28 Gene

Sources for MRPS28 Gene

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