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Aliases for MRPS28 Gene

Aliases for MRPS28 Gene

  • Mitochondrial Ribosomal Protein S28 2 3 5
  • 28S Ribosomal Protein S35, Mitochondrial 3 4
  • MRP-S28 3 4
  • MRP-S35 3 4
  • MRPS35 3 4
  • S28mt 3 4
  • S35mt 3 4
  • Mitochondrial 28S Ribosomal Protein S35 3
  • HSPC007 3

External Ids for MRPS28 Gene

Previous GeneCards Identifiers for MRPS28 Gene

  • GC08M079718
  • GC08M080879
  • GC08M080554
  • GC08M080881
  • GC08M080993
  • GC08M076320
  • GC08M080830

Summaries for MRPS28 Gene

Entrez Gene Summary for MRPS28 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that has been called mitochondrial ribosomal protein S35 in the literature. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS28 Gene

MRPS28 (Mitochondrial Ribosomal Protein S28) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding.

Gene Wiki entry for MRPS28 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS28 Gene

Genomics for MRPS28 Gene

Regulatory Elements for MRPS28 Gene

Enhancers for MRPS28 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPS28 on UCSC Golden Path with GeneCards custom track

Promoters for MRPS28 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPS28 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPS28 Gene

79,918,717 bp from pter
80,030,289 bp from pter
111,573 bases
Minus strand

Genomic View for MRPS28 Gene

Genes around MRPS28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS28 Gene

Proteins for MRPS28 Gene

  • Protein details for MRPS28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S28, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B2RDZ7
    • Q96Q21

    Protein attributes for MRPS28 Gene

    187 amino acids
    Molecular mass:
    20843 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS28 Gene

neXtProt entry for MRPS28 Gene

Proteomics data for MRPS28 Gene at MOPED

Post-translational modifications for MRPS28 Gene

  • Ubiquitination at Lys 75
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for MRPS28 Gene

Domains & Families for MRPS28 Gene

Gene Families for MRPS28 Gene

Protein Domains for MRPS28 Gene


Suggested Antigen Peptide Sequences for MRPS28 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPS28: view

No data available for UniProtKB/Swiss-Prot for MRPS28 Gene

Function for MRPS28 Gene

genes like me logo Genes that share phenotypes with MRPS28: view

Animal Model Products

miRNA for MRPS28 Gene

miRTarBase miRNAs that target MRPS28

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS28 Gene

Localization for MRPS28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS28 Gene


Subcellular locations from

Jensen Localization Image for MRPS28 Gene COMPARTMENTS Subcellular localization image for MRPS28 gene
Compartment Confidence
mitochondrion 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for MRPS28 Gene

Pathways & Interactions for MRPS28 Gene

genes like me logo Genes that share pathways with MRPS28: view

Gene Ontology (GO) - Biological Process for MRPS28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MRPS28: view

No data available for SIGNOR curated interactions for MRPS28 Gene

Drugs & Compounds for MRPS28 Gene

No Compound Related Data Available

Transcripts for MRPS28 Gene

Unigene Clusters for MRPS28 Gene

Mitochondrial ribosomal protein S28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS28 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - - -
SP2: - -
SP3: -
SP4: - - - - -

Relevant External Links for MRPS28 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS28 Gene

mRNA expression in normal human tissues for MRPS28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS28 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.6), Breast (10.1), Lung (9.6), and Pancreas (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MRPS28 Gene

SOURCE GeneReport for Unigene cluster for MRPS28 Gene Hs.521124

genes like me logo Genes that share expression patterns with MRPS28: view

Protein tissue co-expression partners for MRPS28 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS28 Gene

Orthologs for MRPS28 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS28 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS28 35
  • 86.56 (n)
  • 85.48 (a)
MRPS28 36
  • 84 (a)
(Canis familiaris)
Mammalia MRPS28 35
  • 84.59 (n)
  • 81.72 (a)
MRPS28 36
  • 81 (a)
(Mus musculus)
Mammalia Mrps28 35
  • 76.52 (n)
  • 73.66 (a)
Mrps28 16
Mrps28 36
  • 73 (a)
(Pan troglodytes)
Mammalia MRPS28 35
  • 98.22 (n)
  • 97.33 (a)
MRPS28 36
  • 97 (a)
(Monodelphis domestica)
Mammalia MRPS28 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100124857 35
  • 64.5 (n)
  • 70.73 (a)
Str.1431 35
(Danio rerio)
Actinopterygii Dr.14825 35
mrps28 35
  • 56.59 (n)
  • 55.23 (a)
mrps28 36
  • 53 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4190 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006650 35
  • 54.74 (n)
  • 54.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS28 35
  • 54.14 (n)
  • 46.62 (a)
mRpS28 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea mrps-28 36
  • 32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
Species with no ortholog for MRPS28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS28 Gene

Gene Tree for MRPS28 (if available)
Gene Tree for MRPS28 (if available)

Paralogs for MRPS28 Gene

genes like me logo Genes that share paralogs with MRPS28: view

No data available for Paralogs for MRPS28 Gene

Variants for MRPS28 Gene

Sequence variations from dbSNP and Humsavar for MRPS28 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs16919579 - 80,003,087(+) GATCC(A/G)TCCAA reference, missense
rs2044968 -- 79,970,333(-) AAATT(A/C)TTCTT intron-variant
rs2053962 -- 79,958,675(-) AATAT(C/T)AGGGC intron-variant
rs2114206 -- 80,014,077(+) AAATT(C/T)AAGAA intron-variant
rs2123268 -- 80,016,705(-) catga(A/G)caaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS28 Gene

Variant ID Type Subtype PubMed ID
esv2666906 CNV Deletion 23128226
nsv891061 CNV Loss 21882294

Variation tolerance for MRPS28 Gene

Residual Variation Intolerance Score: 78.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.05; 60.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRPS28 Gene

Disorders for MRPS28 Gene

Relevant External Links for MRPS28

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPS28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS28 Gene

Publications for MRPS28 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 67
  2. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for MRPS28 Gene

Sources for MRPS28 Gene