MRPS28 Gene
protein-coding GIFtS: 49
GCID: GC08M080830
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mitochondrial ribosomal protein S28
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Aliases for MRPS28 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein S281 2 | | S28mt2 3 | | MRPS351 2 3 5 | | S35mt2 3 | | MRP-S281 2 3 | | HSPC0071 | | 28S Ribosomal Protein S35, Mitochondrial2 3 | | 28S Ribosomal Protein S28, Mitochondrial2 | | MRP-S352 3 | | Mitochondrial 28S Ribosomal Protein S352 |
Export aliases for MRPS28 gene to outside databasesPrevious GC identifers: GC08M079718 GC08M080879 GC08M080554 GC08M080881 GC08M080993 GC08M076320 |
Summaries for MRPS28 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for MRPS28: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit proteinthat has been called mitochondrial ribosomal protein S35 in the literature. (provided by RefSeq, Jul 2008) Gene Wiki entry for MRPS28
|
Genomic Views for MRPS28 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MRPS28 gene promoter: POU2F1 ATF-2 POU2F1a POU2F1b POU2F1c Hlf Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPS28
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS28 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q21.1-q21.2 Ensembl cytogenetic band: 8q21.13 HGNC cytogenetic band: 8q21.1-q21.2MRPS28 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M080830: view genomic region
(about GC identifiers)
Start:
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80,830,952 bp from pter |
End:
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80,942,524 bp from pter |
Size:
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111,573 bases |
Orientation:
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minus strand |
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Proteins for MRPS28 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RT28_HUMAN, Q9Y2Q9 (See
protein sequence)Recommended Name: 28S ribosomal protein S28, mitochondrial precursor Size: 187 amino acids; 20843 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinctproteins
Subcellular location: Mitochondrion
Secondary accessions: B2RDZ7 Q96Q21Explore the universe of human proteins at neXtProt for MRPS28: NX_Q9Y2Q9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y2Q9 MRPS28 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_054737.1 ENSEMBL proteins: ENSP00000276585 ENSP00000430858 ENSP00000428050 ENSP00000428880 ENSP00000427965 ENSP00000428744 ENSP00000430401 ENSP00000427846 Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MRPS28 for ontologies About GeneDecksing
MRPS28 Antibody Products: Assay Products for MRPS28: |
Protein
Domains / Families for MRPS28 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPS28 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y2Q9ProtoNet protein and cluster: Q9Y2Q9 1 Blocks protein family: IPB003029 RNA binding S1
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Function for MRPS28 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS28 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS28 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRPS28 (NM_014018) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS28 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS28  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS28 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
MRPS28 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for MRPS28:
|
Pathways & Interactions for MRPS28 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS28
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
 5/236 Interacting proteins for MRPS28 (Q9Y2Q92, 3 ENSP000002765854) via UniProtKB, MINT, STRING, and/or I2D (see all 236)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
MRPS28 for ontologies About GeneDecksing
|
Drugs & Compounds for MRPS28 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for MRPS28 Search CenterWatch for drugs/clinical trials and news about MRPS28 / RT28 
|
Transcripts for MRPS28 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for MRPS28 gene: NM_014018.2 Unigene Cluster for MRPS28: Mitochondrial ribosomal protein S28 Hs.521124 [show with all ESTs]Unigene Representative Sequence: BM91895510 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000276585(uc003ybp.3) ENST00000522938 ENST00000519386 ENST00000521434 ENST00000521605 ENST00000519120 ENST00000520946 ENST00000518271 ENST00000518371 ENST00000522987
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS28 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS28 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRPS28 (NM_014018) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS28 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS28  |
Additional cDNA sequence: AF070663.1 AK026506.1 AK223069.1 AK315739.1 BC010150.1 12 DOTS entries: DT.97861889 DT.95269386 DT.92433443 DT.446843 DT.97861890 DT.416197 DT.416198 DT.100813049 DT.100813050 DT.120643319 DT.92433445 DT.92010984 24/159 AceView cDNA sequences (see all 159): AA825586 CR616931 BF509641 AA743550 BM840971 AA971612 BG472534 AA844635 N95051 BU738666 BQ420707 AL552031 BC010150 AI253698 CA431606 AA769871 AA648415 BU634244 AA846234 AA932612 AA860736 BM840470 NM_014018 AA010860 GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS28 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | |
| SP1: | |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for MRPS28
|
Expression for MRPS28 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPS28 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AAAAATAAAT
About this image See MRPS28 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MRPS28
SOURCE GeneReport for Unigene cluster: Hs.521124 SABiosciences Custom PCR Arrays for MRPS28
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS28 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPS28 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS28 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS28 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS28 |
Orthologs for MRPS28 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MRPS28 gene from 6/19 species (see all 19) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Mrps281 , 5 |
mitochondrial ribosomal protein S281, 5 |
76.52(n)1 73.66(a)1 |
  |
3 (2.17 cM)5 662301 NM_025434.31 NP_079710.31 88021465 |
chicken (Gallus gallus) |
Aves |
MRPS281 |
mitochondrial ribosomal protein S28 |
71.01(n) 80(a) |
  |
770322 XM_001233657.2 XP_001233658.2 |
tropical clawed frog (Xenopus tropicalis) |
Amphibia |
Str.14312 |
Transcribed sequence with weak similarity to protein more |
72.52(n) |
  |
AL775404.2 |
zebrafish (Danio rerio) |
Actinopterygii |
Dr.148252 |
Transcribed sequence with weak similarity to protein more |
68.01(n) |
  |
BM958205.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
mRpS281 |
mitochondrial ribosomal protein S28 |
52.78(n) 43.75(a) |
  |
37136 NM_079061.3 NP_523785.2 |
worm (Caenorhabditis elegans) |
Secernentea |
mrps-286 |
Protein MRPS-28 |
33(a) |
1 ↔ 1 |
V(19644209-19645728) |
ENSEMBL Gene Tree for MRPS28 (if available) TreeFam Gene Tree for MRPS28 (if available)  |
Paralogs for MRPS28 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for MRPS28 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 8 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPS28 (80830952 - 80942524 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MRPS28: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS28 |
|
Disorders
/ Diseases for MRPS28 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRPS28 for disorders About MalaCards
MRPS28 for disorders About GeneDecksing
OMIM gene information: 611990
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MRPS28 (1 document) Export disorders for MRPS28 gene to outside databases
|
Publications for MRPS28 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPS28 gene, integrated from 9 sources (see all 20): (articles sorted by number of sources associating them with MRPS28) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2 Kenmochi N....Tanaka T. (2001)
- The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 3 Koc E.C.... Spremulli L.L. (2001)
- A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. (PubMed id 10938081)1, 2 Koc E.C....Spremulli L.L. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for MRPS28 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing MRPS28 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPS28 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPS28 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for MRPS28 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRPS28 gene: Search GeneIP for patents involving MRPS28
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for MRPS28 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | OriGene Custom Antibody Services for MRPS28 | | OriGene Custom Protein Services for MRPS28 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPS28 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS28 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS28 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPS28 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS28 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS28 |
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| |  |  |  |  | | | | |
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 | | MRPS28 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS28 |
|  |  |  | | | ThermoFisher Antibody for MRPS28 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS28 |
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