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Aliases for MRPS27 Gene

Aliases for MRPS27 Gene

  • Mitochondrial Ribosomal Protein S27 2 3 5
  • MRP-S27 3 4
  • S27mt 3 4
  • 28S Ribosomal Protein S27, Mitochondrial 3
  • Mitochondrial 28S Ribosomal Protein S27 3
  • KIAA0264 4

External Ids for MRPS27 Gene

Previous GeneCards Identifiers for MRPS27 Gene

  • GC05M070320
  • GC05M071748
  • GC05M071554
  • GC05M071600
  • GC05M071601
  • GC05M071551
  • GC05M066720

Summaries for MRPS27 Gene

Entrez Gene Summary for MRPS27 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that may be a functional partner of the death associated protein 3 (DAP3). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013]

GeneCards Summary for MRPS27 Gene

MRPS27 (Mitochondrial Ribosomal Protein S27) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS27 Gene

Genomics for MRPS27 Gene

Regulatory Elements for MRPS27 Gene

Enhancers for MRPS27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F072362 0.8 FANTOM5 Ensembl ENCODE 19.1 -43.2 -43182 2.7 CTCF PKNOX1 JUN ZFP64 CEBPB RAD21 ZNF121 JUND FOS MRPS27 PTCD2 RN7SL153P ZNF366 RPL10AP8 GC05P072368
GH05F072244 0.8 Ensembl ENCODE 17.1 +73.7 73732 5.0 PKNOX1 ATF1 SIN3A FEZF1 BRCA1 ZNF2 KLF7 FOS TSHZ1 REST MAP1B MRPS27 PTCD2 RN7SL153P GC05M072061
GH05F072237 0.7 ENCODE 16.7 +81.7 81722 1.9 ATF1 REST ZNF121 RFXANK IKZF1 FOXJ2 CREM ZNF18 MAP1B MRPS27 RN7SL153P PTCD2 GC05M072061
GH05F072280 1.2 Ensembl ENCODE 15.7 +38.4 38379 2.8 PKNOX1 ATF1 ARNT FEZF1 GATA2 SP3 REST TSHZ1 ZNF488 ZNF518A MRPS27 MAP1B RN7SL153P PTCD2 GC05M072061
GH05F072349 1 FANTOM5 Ensembl 11.4 -29.4 -29401 1.1 MAP1B PTCD2 MRPS27 RN7SL153P ZNF366 GC05P072368
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MRPS27 on UCSC Golden Path with GeneCards custom track

Promoters for MRPS27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001282436 546 2601 PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF548

Genomic Location for MRPS27 Gene

Chromosome:
5
Start:
72,219,409 bp from pter
End:
72,320,646 bp from pter
Size:
101,238 bases
Orientation:
Minus strand

Genomic View for MRPS27 Gene

Genes around MRPS27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS27 Gene

Proteins for MRPS27 Gene

  • Protein details for MRPS27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92552-RT27_HUMAN
    Recommended name:
    28S ribosomal protein S27, mitochondrial
    Protein Accession:
    Q92552
    Secondary Accessions:
    • B4DRT2
    • Q6P1S1

    Protein attributes for MRPS27 Gene

    Size:
    414 amino acids
    Molecular mass:
    47611 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Interacts with NOA1.
    SequenceCaution:
    • Sequence=BAA13394.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS27 Gene

    Alternative splice isoforms for MRPS27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPS27 Gene

Post-translational modifications for MRPS27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS27 Gene

No data available for DME Specific Peptides for MRPS27 Gene

Domains & Families for MRPS27 Gene

Gene Families for MRPS27 Gene

Protein Domains for MRPS27 Gene

Graphical View of Domain Structure for InterPro Entry

Q92552

UniProtKB/Swiss-Prot:

RT27_HUMAN :
  • Contains 2 PPR (pentatricopeptide) repeats.
Similarity:
  • Contains 2 PPR (pentatricopeptide) repeats.
genes like me logo Genes that share domains with MRPS27: view

Function for MRPS27 Gene

Gene Ontology (GO) - Molecular Function for MRPS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19103604
genes like me logo Genes that share ontologies with MRPS27: view
genes like me logo Genes that share phenotypes with MRPS27: view

Animal Model Products

miRNA for MRPS27 Gene

miRTarBase miRNAs that target MRPS27

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS27 Gene

Localization for MRPS27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS27 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS27 Gene COMPARTMENTS Subcellular localization image for MRPS27 gene
Compartment Confidence
mitochondrion 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MRPS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IBA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MRPS27: view

Pathways & Interactions for MRPS27 Gene

genes like me logo Genes that share pathways with MRPS27: view

Gene Ontology (GO) - Biological Process for MRPS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS27: view

No data available for SIGNOR curated interactions for MRPS27 Gene

Transcripts for MRPS27 Gene

Unigene Clusters for MRPS27 Gene

Mitochondrial ribosomal protein S27:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS27 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c
SP1: - - - - - - - -
SP2: - -
SP3: - -
SP4: - - - -
SP5: -
SP6: - -
SP7: - - -
SP8: -
SP9: -

Relevant External Links for MRPS27 Gene

GeneLoc Exon Structure for
MRPS27
ECgene alternative splicing isoforms for
MRPS27

Expression for MRPS27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPS27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS27 Gene

This gene is overexpressed in Pancreas (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS27 Gene



Protein tissue co-expression partners for MRPS27 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS27 Gene:

MRPS27

SOURCE GeneReport for Unigene cluster for MRPS27 Gene:

Hs.482491
genes like me logo Genes that share expression patterns with MRPS27: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS27 Gene

Orthologs for MRPS27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPS27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS27 34 35
  • 99.76 (n)
cow
(Bos Taurus)
Mammalia MRPS27 34 35
  • 85.02 (n)
dog
(Canis familiaris)
Mammalia MRPS27 34 35
  • 84.86 (n)
mouse
(Mus musculus)
Mammalia Mrps27 34 16 35
  • 82.01 (n)
rat
(Rattus norvegicus)
Mammalia Mrps27 34
  • 81.93 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPS27 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS27 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS27 34 35
  • 68.52 (n)
lizard
(Anolis carolinensis)
Reptilia MRPS27 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps27 34
  • 62.13 (n)
Str.2771 34
zebrafish
(Danio rerio)
Actinopterygii mrps27 34 35
  • 58.68 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3671 34
Species where no ortholog for MRPS27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS27 Gene

ENSEMBL:
Gene Tree for MRPS27 (if available)
TreeFam:
Gene Tree for MRPS27 (if available)

Paralogs for MRPS27 Gene

No data available for Paralogs for MRPS27 Gene

Variants for MRPS27 Gene

Sequence variations from dbSNP and Humsavar for MRPS27 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10036009 -- 72,225,604(+) CATCA(C/G)CATCA intron-variant
rs10040432 -- 72,288,401(+) aaaga(C/T)ggggt intron-variant
rs10042732 -- 72,266,899(+) TACCA(C/T)TAGGT intron-variant
rs10050949 -- 72,276,827(+) gagat(C/G/T)gagac intron-variant
rs10057030 -- 72,257,558(+) GTTTC(A/G)GAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS27 Gene

Variant ID Type Subtype PubMed ID
esv1008339 CNV insertion 20482838
nsv1117561 CNV deletion 24896259

Variation tolerance for MRPS27 Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.59; 86.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS27 Gene

Disorders for MRPS27 Gene

Relevant External Links for MRPS27

Genetic Association Database (GAD)
MRPS27
Human Genome Epidemiology (HuGE) Navigator
MRPS27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS27

No disorders were found for MRPS27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS27 Gene

Publications for MRPS27 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis. (PMID: 19103604) Tang T. … Farquhar M.G. (J. Biol. Chem. 2009) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach. (PMID: 11344316) Koc E.C. … Spremulli L.L. (Protein Sci. 2001) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4 64

Products for MRPS27 Gene

Sources for MRPS27 Gene

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