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Aliases for MRPS27 Gene

Aliases for MRPS27 Gene

  • Mitochondrial Ribosomal Protein S27 2 3 5
  • MRP-S27 3 4
  • S27mt 3 4
  • Mitochondrial 28S Ribosomal Protein S27 3
  • KIAA0264 4

External Ids for MRPS27 Gene

Previous GeneCards Identifiers for MRPS27 Gene

  • GC05M070320
  • GC05M071748
  • GC05M071554
  • GC05M071600
  • GC05M071601
  • GC05M071551
  • GC05M066720

Summaries for MRPS27 Gene

Entrez Gene Summary for MRPS27 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that may be a functional partner of the death associated protein 3 (DAP3). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013]

GeneCards Summary for MRPS27 Gene

MRPS27 (Mitochondrial Ribosomal Protein S27) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS27 Gene

Genomics for MRPS27 Gene

Regulatory Elements for MRPS27 Gene

Enhancers for MRPS27 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPS27 on UCSC Golden Path with GeneCards custom track

Promoters for MRPS27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPS27 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPS27 Gene

72,219,409 bp from pter
72,320,646 bp from pter
101,238 bases
Minus strand

Genomic View for MRPS27 Gene

Genes around MRPS27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS27 Gene

Proteins for MRPS27 Gene

  • Protein details for MRPS27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S27, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B4DRT2
    • Q6P1S1

    Protein attributes for MRPS27 Gene

    414 amino acids
    Molecular mass:
    47611 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Interacts with NOA1.
    • Sequence=BAA13394.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS27 Gene

    Alternative splice isoforms for MRPS27 Gene


neXtProt entry for MRPS27 Gene

Proteomics data for MRPS27 Gene at MOPED

Post-translational modifications for MRPS27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS27 Gene

No data available for DME Specific Peptides for MRPS27 Gene

Domains & Families for MRPS27 Gene

Gene Families for MRPS27 Gene

Protein Domains for MRPS27 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 PPR (pentatricopeptide) repeats.
  • Contains 2 PPR (pentatricopeptide) repeats.
genes like me logo Genes that share domains with MRPS27: view

Function for MRPS27 Gene

genes like me logo Genes that share phenotypes with MRPS27: view

Animal Model Products

miRNA for MRPS27 Gene

miRTarBase miRNAs that target MRPS27

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS27 Gene

Localization for MRPS27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS27 Gene


Subcellular locations from

Jensen Localization Image for MRPS27 Gene COMPARTMENTS Subcellular localization image for MRPS27 gene
Compartment Confidence
mitochondrion 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MRPS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPS27: view

Pathways & Interactions for MRPS27 Gene

genes like me logo Genes that share pathways with MRPS27: view

Gene Ontology (GO) - Biological Process for MRPS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPS27: view

No data available for SIGNOR curated interactions for MRPS27 Gene

Drugs & Compounds for MRPS27 Gene

No Compound Related Data Available

Transcripts for MRPS27 Gene

Unigene Clusters for MRPS27 Gene

Mitochondrial ribosomal protein S27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS27 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c
SP1: - - - - - - - -
SP2: - -
SP3: - -
SP4: - - - -
SP5: -
SP6: - -
SP7: - - -
SP8: -
SP9: -

Relevant External Links for MRPS27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS27 Gene

mRNA expression in normal human tissues for MRPS27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS27 Gene

This gene is overexpressed in Pancreas (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS27 Gene

SOURCE GeneReport for Unigene cluster for MRPS27 Gene Hs.482491

genes like me logo Genes that share expression patterns with MRPS27: view

Protein tissue co-expression partners for MRPS27 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS27 Gene

Orthologs for MRPS27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPS27 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS27 35
  • 85.02 (n)
  • 82.47 (a)
MRPS27 36
  • 82 (a)
(Canis familiaris)
Mammalia MRPS27 35
  • 84.86 (n)
  • 82.47 (a)
MRPS27 36
  • 79 (a)
(Mus musculus)
Mammalia Mrps27 35
  • 82.01 (n)
  • 77.48 (a)
Mrps27 16
Mrps27 36
  • 76 (a)
(Pan troglodytes)
Mammalia MRPS27 35
  • 99.76 (n)
  • 99.76 (a)
MRPS27 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrps27 35
  • 81.93 (n)
  • 78.96 (a)
(Monodelphis domestica)
Mammalia MRPS27 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS27 36
  • 67 (a)
(Gallus gallus)
Aves MRPS27 35
  • 68.52 (n)
  • 65.91 (a)
MRPS27 36
  • 65 (a)
(Anolis carolinensis)
Reptilia MRPS27 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps27 35
  • 62.13 (n)
  • 59.95 (a)
Str.2771 35
(Danio rerio)
Actinopterygii mrps27 35
  • 58.68 (n)
  • 53.35 (a)
mrps27 36
  • 52 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3671 35
Species with no ortholog for MRPS27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS27 Gene

Gene Tree for MRPS27 (if available)
Gene Tree for MRPS27 (if available)

Paralogs for MRPS27 Gene

No data available for Paralogs for MRPS27 Gene

Variants for MRPS27 Gene

Sequence variations from dbSNP and Humsavar for MRPS27 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs3209157 - 72,223,837(-) GCTGG(A/G)TGCAG reference, missense
rs6831 -- 72,219,789(-) GTGCA(C/T)GCACA utr-variant-3-prime
rs893534 -- 72,284,486(+) AGAGA(G/T)ATGGA intron-variant
rs904719 -- 72,312,287(+) TTTTT(A/T)ATGGA intron-variant
rs961466 -- 72,303,378(-) TATCT(A/G)CCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS27 Gene

Variant ID Type Subtype PubMed ID
esv1008339 CNV Insertion 20482838

Variation tolerance for MRPS27 Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.59; 86.15% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRPS27 Gene

Disorders for MRPS27 Gene

Relevant External Links for MRPS27

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPS27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS27 Gene

Publications for MRPS27 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for MRPS27 Gene

Sources for MRPS27 Gene