Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPS27 Gene

Aliases for MRPS27 Gene

  • Mitochondrial Ribosomal Protein S27 2 3
  • KIAA0264 4 6
  • MRP-S27 3 4
  • S27mt 3 4
  • 28S Ribosomal Protein S27, Mitochondrial 3
  • Mitochondrial 28S Ribosomal Protein S27 3

External Ids for MRPS27 Gene

Previous GeneCards Identifiers for MRPS27 Gene

  • GC05M070320
  • GC05M071748
  • GC05M071554
  • GC05M071600
  • GC05M071601
  • GC05M071551
  • GC05M066720

Summaries for MRPS27 Gene

Entrez Gene Summary for MRPS27 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that may be a functional partner of the death associated protein 3 (DAP3). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013]

GeneCards Summary for MRPS27 Gene

MRPS27 (Mitochondrial Ribosomal Protein S27) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS27 Gene

Genomics for MRPS27 Gene

Regulatory Elements for MRPS27 Gene

Genomic Location for MRPS27 Gene

72,219,409 bp from pter
72,320,646 bp from pter
101,238 bases
Minus strand

Genomic View for MRPS27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS27 Gene

Proteins for MRPS27 Gene

  • Protein details for MRPS27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S27, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B4DRT2
    • Q6P1S1

    Protein attributes for MRPS27 Gene

    414 amino acids
    Molecular mass:
    47611 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Interacts with NOA1.
    • Sequence=BAA13394.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MRPS27 Gene


neXtProt entry for MRPS27 Gene

Proteomics data for MRPS27 Gene at MOPED

Post-translational modifications for MRPS27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS27 Gene

Antibody Products

No data available for DME Specific Peptides for MRPS27 Gene

Domains for MRPS27 Gene

Gene Families for MRPS27 Gene

Protein Domains for MRPS27 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 PPR (pentatricopeptide) repeats.
  • Contains 2 PPR (pentatricopeptide) repeats.
genes like me logo Genes that share domains with MRPS27: view

Function for MRPS27 Gene

Gene Ontology (GO) - Molecular Function for MRPS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19103604
genes like me logo Genes that share ontologies with MRPS27: view

Phenotypes for MRPS27 Gene

GenomeRNAi human phenotypes for MRPS27:
genes like me logo Genes that share phenotypes with MRPS27: view

Animal Model Products

miRNA for MRPS27 Gene

miRTarBase miRNAs that target MRPS27

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS27

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS27 Gene

Localization for MRPS27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS27 Gene


Subcellular locations from

Jensen Localization Image for MRPS27 Gene COMPARTMENTS Subcellular localization image for MRPS27 gene
Compartment Confidence
mitochondrion 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MRPS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS27: view

Pathways for MRPS27 Gene

SuperPathways for MRPS27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRPS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS27: view

No data available for Pathways by source for MRPS27 Gene

Transcripts for MRPS27 Gene

Unigene Clusters for MRPS27 Gene

Mitochondrial ribosomal protein S27:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS27

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS27 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b · 12c
SP1: - - - - - - - -
SP2: - -
SP3: - -
SP4: - - - -
SP5: -
SP6: - -
SP7: - - -
SP8: -
SP9: -

Relevant External Links for MRPS27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS27 Gene

mRNA expression in normal human tissues for MRPS27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MRPS27 Gene

This gene is overexpressed in Pancreas (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS27 Gene

SOURCE GeneReport for Unigene cluster for MRPS27 Gene Hs.482491

genes like me logo Genes that share expressions with MRPS27: view

Expression partners for MRPS27 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS27 Gene

Orthologs for MRPS27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPS27 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS27 35
  • 85.02 (n)
  • 82.47 (a)
MRPS27 36
  • 82 (a)
(Canis familiaris)
Mammalia MRPS27 35
  • 84.86 (n)
  • 82.47 (a)
MRPS27 36
  • 79 (a)
(Mus musculus)
Mammalia Mrps27 35
  • 82.01 (n)
  • 77.48 (a)
Mrps27 16
Mrps27 36
  • 76 (a)
(Pan troglodytes)
Mammalia MRPS27 35
  • 99.76 (n)
  • 99.76 (a)
MRPS27 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrps27 35
  • 81.93 (n)
  • 78.96 (a)
(Monodelphis domestica)
Mammalia MRPS27 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS27 36
  • 67 (a)
(Gallus gallus)
Aves MRPS27 35
  • 68.52 (n)
  • 65.91 (a)
MRPS27 36
  • 65 (a)
(Anolis carolinensis)
Reptilia MRPS27 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps27 35
  • 62.13 (n)
  • 59.95 (a)
Str.2771 35
(Danio rerio)
Actinopterygii mrps27 35
  • 58.68 (n)
  • 53.35 (a)
mrps27 36
  • 52 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3671 35
Species with no ortholog for MRPS27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS27 Gene

Gene Tree for MRPS27 (if available)
Gene Tree for MRPS27 (if available)

Paralogs for MRPS27 Gene

No data available for Paralogs for MRPS27 Gene

Variants for MRPS27 Gene

Sequence variations from dbSNP and Humsavar for MRPS27 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs77497844 -- 72,300,434(+) CCCTG(A/T)CTTCT intron-variant
rs77320682 -- 72,300,144(+) GCCAC(A/G)TTGTT intron-variant
rs77224730 -- 72,287,975(+) AGCAC(A/G)TACTC intron-variant
rs77204649 -- 72,245,007(+) CCAGG(A/G)AGGAT intron-variant
rs77043085 -- 72,283,364(+) TATCT(G/T)TTGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS27 Gene

Variant ID Type Subtype PubMed ID
esv1008339 CNV Insertion 20482838

Relevant External Links for MRPS27 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS27 Gene

Disorders for MRPS27 Gene

Relevant External Links for MRPS27

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MRPS27 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MRPS27 Gene

Publications for MRPS27 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  2. Identification of four proteins from the small subunit of the mammalian mitochondrial ribosome using a proteomics approach. (PMID: 11344316) Koc E.C. … Spremulli L.L. (Protein Sci. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis. (PMID: 19103604) Tang T. … Farquhar M.G. (J. Biol. Chem. 2009) 3 4
  5. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. (PMID: 9039502) Nagase T. … Nomura N. (DNA Res. 1996) 3 4

Products for MRPS27 Gene

Sources for MRPS27 Gene

Back to Top