MRPS26 Gene
protein-coding GIFtS: 47
GCID: GC20P003039
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mitochondrial ribosomal protein S26(Previous name: chromosome 20 open reading frame 193 )
(Previous symbol: C20orf193)
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Aliases
for MRPS26 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
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| Mitochondrial Ribosomal Protein S261 2 | | S26mt2 3 | | C20orf1931 2 3 | | MRPS132 5 | | MRP-S131 2 3 | | Chromosome 20 Open Reading Frame 1931 | | MRP-S261 2 3 | | 28S Ribosomal Protein S26, Mitochondrial2 | | RPMS131 2 3 | | GI0082 | | DJ534B8.31 | | NY-BR-872 | | 28S Ribosomal Protein S13, Mitochondrial2 3 | | Serologically Defined Breast Cancer Antigen NY-BR-872 | | S13mt2 3 | | |
Export aliases for MRPS26 gene to outside databasesPrevious GC identifers: GC20P003014 GC20P002974 GC20P003021 GC20P003034 |
Summaries
for MRPS26 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPS26:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein.This gene lies adjacent to and downstream of the gonadotropin-releasing hormone precursor gene. (provided by RefSeq,Jul 2008)
Gene Wiki entry for MRPS26
|
Genomic Views
for MRPS26 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000020.10 NC_018931.1 NT_011387.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPS26 gene promoter:
CREB POU2F1 AP-1 POU2F1a deltaCREB NF-kappaB1 NF-kappaB ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPS26
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS26 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13MRPS26 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20P003039: view genomic region
(about GC identifiers)
Start:
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3,026,591 bp from pter |
End:
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3,028,900 bp from pter |
Size:
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2,310 bases |
Orientation:
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plus strand |
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Proteins
for MRPS26 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RT26_HUMAN, Q9BYN8 (See
protein sequence)Recommended Name: 28S ribosomal protein S26, mitochondrial precursor Size: 205 amino acids; 24212 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinctproteins
Subcellular location: Mitochondrion
Secondary accessions: Q96Q58Explore the universe of human proteins at neXtProt for MRPS26: NX_Q9BYN8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BYN8
MRPS26 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_110438.1
ENSEMBL proteins: ENSP00000369682
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MRPS26 for ontologies About GeneDecksing
MRPS26 Antibody Products:
Assay Products for MRPS26: |
Protein
Domains /
Families
for MRPS26 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPS26 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BYN8ProtoNet protein and cluster: Q9BYN8 |
Function
for MRPS26 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS26 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS26
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for MRPS26 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS26 |
1 GenomeRNAi human phenotype for MRPS26:
|
Pathways & Interactions
for MRPS26 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS26
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/236 Interacting proteins for MRPS26 (Q9BYN82, 3 ENSP000003696824) via UniProtKB, MINT, STRING, and/or I2D (see all 236)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
MRPS26 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRPS26 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPS26
Search CenterWatch for drugs/clinical trials and news about MRPS26 / RT26
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Transcripts
for MRPS26 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPS26 gene: NM_030811.3 Unigene Cluster for MRPS26: Mitochondrial ribosomal protein S26 Hs.18946 [show with all ESTs]Unigene Representative Sequence: BQ0714721 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000380325(uc002whs.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS26 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS26
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRPS26 (NM_030811) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS26 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS26 |
Additional cDNA sequence: AF308301.1 BC013018.2 5 DOTS entries: DT.447842 DT.95102175 DT.120832513 DT.91753003 DT.97824982 24/263 AceView cDNA sequences (see all 263): BU789005 BQ084044 CD367033 BE392557 AW015379 BM559830 AW009532 CA841035 AI142030 BU845784 BI252914 AI564942 BC013018 AA806534 AI057633 BM797682 BU948696 AI192087 BQ648767 AI472080 BM838324 BM549233 BQ935787 AI298561
GeneLoc Exon Structure
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Expression
for MRPS26 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPS26 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGGAAGAGT
About this image
See MRPS26 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPS26
SOURCE GeneReport for Unigene cluster: Hs.18946
SABiosciences Custom PCR Arrays for MRPS26
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS26
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPS26 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS26 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS26 |
Orthologs
for MRPS26 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MRPS26 gene from 5/13 species (see all 13) About this table
ENSEMBL Gene Tree for MRPS26 (if available)
TreeFam Gene Tree for MRPS26 (if available) |
Paralogs
for MRPS26 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MRPS26 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for MRPS26 (3026591 - 3028900 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MRPS26
1 CNV: 7305 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS26 |
|
Disorders
/ Diseases
for MRPS26 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRPS26 for disorders About GeneDecksing
OMIM gene information: 611988
OMIM disorders: --
3  diseases for MRPS26: About MalaCardsdubin-johnson syndrome breast cancer gout
Human Genome Epidemiology (HuGE) Navigator: MRPS26 (1 document)
Export disorders for MRPS26 gene to outside databases
|
Publications
for MRPS26 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPS26 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with MRPS26) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2, 3 Kenmochi N....Tanaka T. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
- The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2 Koc E.C.... Spremulli L.L. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
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External Searches for MRPS26 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MRPS26 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPS26 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPS26 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPS26 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MRPS26 gene:
Search GeneIP for patents involving MRPS26
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPS26 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRPS26 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPS26 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS26 | | | OriGene Protein Over-expression Lysate for MRPS26 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRPS26 | | OriGene 3'-UTR Clone for MRPS26 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS26 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS26 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPS26 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS26 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS26 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPS26 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS26 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS26 |
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| | | | Search Tocris compounds for MRPS26 |
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 | | | MRPS26 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for MRPS26 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS26 |
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