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Aliases for MRPS26 Gene

Aliases for MRPS26 Gene

  • Mitochondrial Ribosomal Protein S26 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein MS26 3 4
  • 28S Ribosomal Protein S13, Mitochondrial 3 4
  • C20orf193 3 4
  • MRP-S13 3 4
  • MRP-S26 3 4
  • RPMS13 3 4
  • S13mt 3 4
  • S26mt 3 4
  • Serologically Defined Breast Cancer Antigen NY-BR-87 3
  • 28S Ribosomal Protein S26, Mitochondrial 3
  • Chromosome 20 Open Reading Frame 193 2
  • DJ534B8.3 3
  • NY-BR-87 3
  • MRPS13 3
  • GI008 3

External Ids for MRPS26 Gene

Previous HGNC Symbols for MRPS26 Gene

  • C20orf193

Previous GeneCards Identifiers for MRPS26 Gene

  • GC20P003014
  • GC20P002974
  • GC20P003021
  • GC20P003034
  • GC20P003039
  • GC20P003044

Summaries for MRPS26 Gene

Entrez Gene Summary for MRPS26 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. This gene lies adjacent to and downstream of the gonadotropin-releasing hormone precursor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS26 Gene

MRPS26 (Mitochondrial Ribosomal Protein S26) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding.

Gene Wiki entry for MRPS26 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS26 Gene

Genomics for MRPS26 Gene

Regulatory Elements for MRPS26 Gene

Enhancers for MRPS26 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G003044 1.1 ENCODE 23.6 +0.0 11 2.6 HDGF HNRNPUL1 PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 MRPS26 VPS16 ITPA GC20P003063
GH20G003041 1 Ensembl ENCODE 23.7 -3.3 -3254 2.4 SOX13 FOXA2 FOXA3 MXD4 MAX NR2F2 GABPA YY1 FOXA1 TEAD3 MRPS26 GNRH2
GH20G003106 1.1 Ensembl ENCODE 12.2 +61.1 61149 0.9 ELF3 MLX ARID4B DMAP1 THRB ZNF48 RARA CREM MIXL1 THAP11 LZTS3 MRPS26 GNRH2 OXT UBOX5 ITPA UBOX5-AS1 GC20P003124
GH20G002900 0.7 Ensembl ENCODE 13.6 -144.9 -144882 1.7 ZNF121 NBN ZBTB33 VPS16 MRPS26 PTPRA TMEM239 C20orf141 ENSG00000241690 ITPA GC20M002886
GH20G003081 0.8 ENCODE 10.4 +35.3 35295 0.2 MAX RAD21 RARA HNF4G NR2F6 ZNF652 GATAD2A NFIA NR2F1 NR3C1 MRPS26 LOC101929098 AVP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPS26 on UCSC Golden Path with GeneCards custom track

Promoters for MRPS26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000133728 255 1601 HDGF HNRNPUL1 PKNOX1 MLX CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1

Genomic Location for MRPS26 Gene

Chromosome:
20
Start:
3,045,945 bp from pter
End:
3,048,254 bp from pter
Size:
2,310 bases
Orientation:
Plus strand

Genomic View for MRPS26 Gene

Genes around MRPS26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS26 Gene

Proteins for MRPS26 Gene

  • Protein details for MRPS26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYN8-RT26_HUMAN
    Recommended name:
    28S ribosomal protein S26, mitochondrial
    Protein Accession:
    Q9BYN8
    Secondary Accessions:
    • Q96Q58

    Protein attributes for MRPS26 Gene

    Size:
    205 amino acids
    Molecular mass:
    24212 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS26 Gene

neXtProt entry for MRPS26 Gene

Post-translational modifications for MRPS26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS26 Gene

Domains & Families for MRPS26 Gene

Gene Families for MRPS26 Gene

Protein Domains for MRPS26 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPS26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYN8

UniProtKB/Swiss-Prot:

RT26_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mS26 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mS26 family.
genes like me logo Genes that share domains with MRPS26: view

Function for MRPS26 Gene

Gene Ontology (GO) - Molecular Function for MRPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MRPS26: view

Phenotypes for MRPS26 Gene

genes like me logo Genes that share phenotypes with MRPS26: view

Animal Model Products

CRISPR Products

miRNA for MRPS26 Gene

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS26 Gene

Localization for MRPS26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS26 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS26 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit NAS 11279123
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS26: view

Pathways & Interactions for MRPS26 Gene

genes like me logo Genes that share pathways with MRPS26: view

Gene Ontology (GO) - Biological Process for MRPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042769 DNA damage response, detection of DNA damage NAS 15300802
GO:0043043 peptide biosynthetic process IC 11279123
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS26: view

No data available for SIGNOR curated interactions for MRPS26 Gene

Drugs & Compounds for MRPS26 Gene

No Compound Related Data Available

Transcripts for MRPS26 Gene

mRNA/cDNA for MRPS26 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(263) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRPS26 Gene

Mitochondrial ribosomal protein S26:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS26 Gene

No ASD Table

Relevant External Links for MRPS26 Gene

GeneLoc Exon Structure for
MRPS26
ECgene alternative splicing isoforms for
MRPS26

Expression for MRPS26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS26 Gene

Protein differential expression in normal tissues from HIPED for MRPS26 Gene

This gene is overexpressed in Lung (35.8) and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS26 Gene



Protein tissue co-expression partners for MRPS26 Gene

NURSA nuclear receptor signaling pathways regulating expression of MRPS26 Gene:

MRPS26

SOURCE GeneReport for Unigene cluster for MRPS26 Gene:

Hs.18946

Evidence on tissue expression from TISSUES for MRPS26 Gene

  • Skin(4.2)
  • Nervous system(2.4)
  • Lung(2)
genes like me logo Genes that share expression patterns with MRPS26: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS26 Gene

Orthologs for MRPS26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPS26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS26 34 35
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia MRPS26 34 35
  • 84.07 (n)
dog
(Canis familiaris)
Mammalia MRPS26 34 35
  • 84.07 (n)
mouse
(Mus musculus)
Mammalia Mrps26 34 16 35
  • 79.23 (n)
rat
(Rattus norvegicus)
Mammalia Mrps26 34
  • 77.05 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPS26 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS26 34 35
  • 62.12 (n)
zebrafish
(Danio rerio)
Actinopterygii mrps26 34 35
  • 54.4 (n)
Species where no ortholog for MRPS26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS26 Gene

ENSEMBL:
Gene Tree for MRPS26 (if available)
TreeFam:
Gene Tree for MRPS26 (if available)

Paralogs for MRPS26 Gene

No data available for Paralogs for MRPS26 Gene

Variants for MRPS26 Gene

Sequence variations from dbSNP and Humsavar for MRPS26 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000129573 -- 3,046,214(+) GGTGG(A/T)CCCTG downstream-variant-500B, reference, missense
rs1000336589 -- 3,047,368(+) TGGGC(A/G)ACAGT intron-variant
rs1000546524 -- 3,047,576(+) ACTGG(C/G)AGGCC intron-variant
rs1000917831 -- 3,047,407(+) ATAAA(G/T)AAATA intron-variant
rs1002977246 -- 3,045,541(+) CTCAG(G/T)CTTCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRPS26 Gene

Variant ID Type Subtype PubMed ID
esv33482 CNV loss 17666407
nsv1057187 CNV gain 25217958
nsv585276 CNV gain 21841781
nsv833896 CNV loss 17160897
nsv833897 CNV loss 17160897

Variation tolerance for MRPS26 Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS26 Gene

Disorders for MRPS26 Gene

Relevant External Links for MRPS26

Genetic Association Database (GAD)
MRPS26
Human Genome Epidemiology (HuGE) Navigator
MRPS26
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS26

No disorders were found for MRPS26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS26 Gene

Publications for MRPS26 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 3 4 64
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 64

Products for MRPS26 Gene

Sources for MRPS26 Gene

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