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Aliases for MRPS26 Gene

Aliases for MRPS26 Gene

  • Mitochondrial Ribosomal Protein S26 2 3 5
  • 28S Ribosomal Protein S13, Mitochondrial 3 4
  • C20orf193 3 4
  • MRP-S13 3 4
  • MRP-S26 3 4
  • RPMS13 3 4
  • S13mt 3 4
  • S26mt 3 4
  • Serologically Defined Breast Cancer Antigen NY-BR-87 3
  • Chromosome 20 Open Reading Frame 193 2
  • DJ534B8.3 3
  • NY-BR-87 3
  • MRPS13 3
  • GI008 3

External Ids for MRPS26 Gene

Previous HGNC Symbols for MRPS26 Gene

  • C20orf193

Previous GeneCards Identifiers for MRPS26 Gene

  • GC20P003014
  • GC20P002974
  • GC20P003021
  • GC20P003034
  • GC20P003039
  • GC20P003044

Summaries for MRPS26 Gene

Entrez Gene Summary for MRPS26 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. This gene lies adjacent to and downstream of the gonadotropin-releasing hormone precursor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS26 Gene

MRPS26 (Mitochondrial Ribosomal Protein S26) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. GO annotations related to this gene include poly(A) RNA binding.

Gene Wiki entry for MRPS26 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS26 Gene

Genomics for MRPS26 Gene

Regulatory Elements for MRPS26 Gene

Promoters for MRPS26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPS26 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPS26 Gene

Chromosome:
20
Start:
3,045,945 bp from pter
End:
3,048,254 bp from pter
Size:
2,310 bases
Orientation:
Plus strand

Genomic View for MRPS26 Gene

Genes around MRPS26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS26 Gene

Proteins for MRPS26 Gene

  • Protein details for MRPS26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYN8-RT26_HUMAN
    Recommended name:
    28S ribosomal protein S26, mitochondrial
    Protein Accession:
    Q9BYN8
    Secondary Accessions:
    • Q96Q58

    Protein attributes for MRPS26 Gene

    Size:
    205 amino acids
    Molecular mass:
    24212 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS26 Gene

neXtProt entry for MRPS26 Gene

Proteomics data for MRPS26 Gene at MOPED

Post-translational modifications for MRPS26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS26 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MRPS26 Gene

Domains & Families for MRPS26 Gene

Gene Families for MRPS26 Gene

Protein Domains for MRPS26 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPS26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPS26: view

No data available for UniProtKB/Swiss-Prot for MRPS26 Gene

Function for MRPS26 Gene

Phenotypes for MRPS26 Gene

genes like me logo Genes that share phenotypes with MRPS26: view

Animal Model Products

miRNA for MRPS26 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS26 Gene

Localization for MRPS26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS26 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS26 Gene COMPARTMENTS Subcellular localization image for MRPS26 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with MRPS26: view

Pathways & Interactions for MRPS26 Gene

genes like me logo Genes that share pathways with MRPS26: view

Gene Ontology (GO) - Biological Process for MRPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0043043 peptide biosynthetic process IC 11279123
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPS26: view

No data available for SIGNOR curated interactions for MRPS26 Gene

Drugs & Compounds for MRPS26 Gene

No Compound Related Data Available

Transcripts for MRPS26 Gene

mRNA/cDNA for MRPS26 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(263) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRPS26 Gene

Mitochondrial ribosomal protein S26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS26 Gene

No ASD Table

Relevant External Links for MRPS26 Gene

GeneLoc Exon Structure for
MRPS26
ECgene alternative splicing isoforms for
MRPS26

Expression for MRPS26 Gene

mRNA expression in normal human tissues for MRPS26 Gene

Protein differential expression in normal tissues from HIPED for MRPS26 Gene

This gene is overexpressed in Lung (35.8) and Peripheral blood mononuclear cells (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS26 Gene



SOURCE GeneReport for Unigene cluster for MRPS26 Gene Hs.18946

genes like me logo Genes that share expression patterns with MRPS26: view

Protein tissue co-expression partners for MRPS26 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS26 Gene

Orthologs for MRPS26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPS26 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPS26 35
  • 84.07 (n)
  • 78.05 (a)
MRPS26 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS26 35
  • 84.07 (n)
  • 76.1 (a)
MRPS26 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrps26 35
  • 79.23 (n)
  • 70.35 (a)
Mrps26 16
Mrps26 36
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPS26 35
  • 99.84 (n)
  • 100 (a)
MRPS26 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps26 35
  • 77.05 (n)
  • 69.85 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPS26 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS26 35
  • 62.12 (n)
  • 51.7 (a)
MRPS26 36
  • 30 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mrps26 35
  • 54.4 (n)
  • 52.33 (a)
mrps26 36
  • 41 (a)
OneToOne
Species with no ortholog for MRPS26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS26 Gene

ENSEMBL:
Gene Tree for MRPS26 (if available)
TreeFam:
Gene Tree for MRPS26 (if available)

Paralogs for MRPS26 Gene

No data available for Paralogs for MRPS26 Gene

Variants for MRPS26 Gene

Sequence variations from dbSNP and Humsavar for MRPS26 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1100 -- 3,048,065(-) CTGTA(C/T)ACACC utr-variant-3-prime
rs1101 -- 3,048,068(-) AGGCT(G/T)TACAC utr-variant-3-prime
rs9006 -- 3,046,433(+) CTGGC(A/G)GAGCG reference, synonymous-codon
rs3216762 -- 3,046,770(+) TCCAG(-/C)CGGGG intron-variant
rs2277757 -- 3,046,574(+) GAGAA(A/G)CCCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS26 Gene

Variant ID Type Subtype PubMed ID
nsv912603 CNV Gain 21882294
nsv833896 CNV Loss 17160897
nsv833897 CNV Loss 17160897
esv33482 CNV Loss 17666407

Variation tolerance for MRPS26 Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS26 Gene

HapMap Linkage Disequilibrium report
MRPS26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS26 Gene

Disorders for MRPS26 Gene

Relevant External Links for MRPS26

Genetic Association Database (GAD)
MRPS26
Human Genome Epidemiology (HuGE) Navigator
MRPS26
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS26

No disorders were found for MRPS26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS26 Gene

Publications for MRPS26 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3
  5. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PMID: 23402259) Chen R. … Zhang N. (J. Proteome Res. 2013) 3

Products for MRPS26 Gene

Sources for MRPS26 Gene

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