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Aliases for MRPS26 Gene

Aliases for MRPS26 Gene

  • Mitochondrial Ribosomal Protein S26 2 3
  • 28S Ribosomal Protein S13, Mitochondrial 3 4
  • C20orf193 3 4
  • MRP-S13 3 4
  • MRP-S26 3 4
  • MRPS13 3 6
  • RPMS13 3 4
  • S13mt 3 4
  • S26mt 3 4
  • Serologically Defined Breast Cancer Antigen NY-BR-87 3
  • 28S Ribosomal Protein S26, Mitochondrial 3
  • Chromosome 20 Open Reading Frame 193 2
  • DJ534B8.3 3
  • NY-BR-87 3
  • GI008 3

External Ids for MRPS26 Gene

Previous Symbols for MRPS26 Gene

  • C20orf193

Summaries for MRPS26 Gene

Entrez Gene Summary for MRPS26 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. This gene lies adjacent to and downstream of the gonadotropin-releasing hormone precursor gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS26 Gene

MRPS26 (Mitochondrial Ribosomal Protein S26) is a Protein Coding gene. Diseases associated with MRPS26 include breast cancer.

Gene Wiki entry for MRPS26 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS26 Gene

Genomics for MRPS26 Gene

Genomic Location for MRPS26 Gene

Start:
3,045,945 bp from pter
End:
3,048,254 bp from pter
Size:
2,310 bases
Orientation:
Plus strand

Genomic View for MRPS26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS26 Gene

Regulatory Elements for MRPS26 Gene

Proteins for MRPS26 Gene

  • Protein details for MRPS26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYN8-RT26_HUMAN
    Recommended name:
    28S ribosomal protein S26, mitochondrial
    Protein Accession:
    Q9BYN8
    Secondary Accessions:
    • Q96Q58

    Protein attributes for MRPS26 Gene

    Size:
    205 amino acids
    Molecular mass:
    24212 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins

neXtProt entry for MRPS26 Gene

Proteomics data for MRPS26 Gene at MOPED

Post-translational modifications for MRPS26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS26 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS26 Gene

Domains for MRPS26 Gene

Gene Families for MRPS26 Gene

HGNC:
  • MRPS :Mitochondrial ribosomal proteins / small subunits

Protein Domains for MRPS26 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPS26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPS26: view

No data available for UniProtKB/Swiss-Prot for MRPS26 Gene

Function for MRPS26 Gene

Gene Ontology (GO) - Molecular Function for MRPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MRPS26: view

Phenotypes for MRPS26 Gene

GenomeRNAi human phenotypes for MRPS26:
genes like me logo Genes that share phenotypes with MRPS26: view

miRNA for MRPS26 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPS26 Gene

Localization for MRPS26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS26 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS26 Gene COMPARTMENTS Subcellular localization image for MRPS26 gene
Compartment Confidence
mitochondrion 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit NAS 11279123
genes like me logo Genes that share ontologies with MRPS26: view

Pathways for MRPS26 Gene

SuperPathways for MRPS26 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRPS26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0042769 DNA damage response, detection of DNA damage NAS 15300802
GO:0043043 peptide biosynthetic process IC 11279123
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPS26: view

No data available for Pathways by source for MRPS26 Gene

Transcripts for MRPS26 Gene

mRNA/cDNA for MRPS26 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(263) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRPS26 Gene

Mitochondrial ribosomal protein S26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS26 Gene

No ASD Table

Relevant External Links for MRPS26 Gene

GeneLoc Exon Structure for
MRPS26
ECgene alternative splicing isoforms for
MRPS26

Expression for MRPS26 Gene

mRNA expression in normal human tissues for MRPS26 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS26 Gene

SOURCE GeneReport for Unigene cluster for MRPS26 Gene Hs.18946

genes like me logo Genes that share expressions with MRPS26: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS26 Gene

Orthologs for MRPS26 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPS26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS26 35
  • 99.84 (n)
  • 100 (a)
MRPS26 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPS26 35
  • 84.07 (n)
  • 78.05 (a)
MRPS26 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS26 35
  • 84.07 (n)
  • 76.1 (a)
MRPS26 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrps26 35
  • 79.23 (n)
  • 70.35 (a)
Mrps26 16
Mrps26 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPS26 36
  • 56 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps26 35
  • 77.05 (n)
  • 69.85 (a)
chicken
(Gallus gallus)
Aves MRPS26 35
  • 62.12 (n)
  • 51.7 (a)
MRPS26 36
  • 30 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii mrps26 35
  • 54.4 (n)
  • 52.33 (a)
mrps26 36
  • 41 (a)
OneToOne
Species with no ortholog for MRPS26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS26 Gene

ENSEMBL:
Gene Tree for MRPS26 (if available)
TreeFam:
Gene Tree for MRPS26 (if available)

Paralogs for MRPS26 Gene

No data available for Paralogs for MRPS26 Gene

Variants for MRPS26 Gene

Sequence variations from dbSNP and Humsavar for MRPS26 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1100 -- 3,048,065(-) CTGTA(C/T)ACACC utr-variant-3-prime
rs1101 -- 3,048,068(-) AGGCT(G/T)TACAC utr-variant-3-prime
rs9006 -- 3,046,433(+) CTGGC(A/G)GAGCG synonymous-codon, reference
rs2277757 -- 3,046,574(+) GAGAA(A/G)CCCGG intron-variant
rs3216762 -- 3,046,770(+) TCCAG(-/C)CGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS26 Gene

Variant ID Type Subtype PubMed ID
nsv912603 CNV Gain 21882294
nsv833896 CNV Loss 17160897
nsv833897 CNV Loss 17160897
esv33482 CNV Loss 17666407

Relevant External Links for MRPS26 Gene

HapMap Linkage Disequilibrium report
MRPS26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS26 Gene

Disorders for MRPS26 Gene

(1) MalaCards Diseases for MRPS26 Gene

Search for MRPS26 Gene in MalaCards »

Relevant External Links for MRPS26

Genetic Association Database (GAD)
MRPS26
Human Genome Epidemiology (HuGE) Navigator
MRPS26
genes like me logo Genes that share disorders with MRPS26: view

No data available for UniProtKB/Swiss-Prot for MRPS26 Gene

Publications for MRPS26 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for MRPS26 Gene

Sources for MRPS26 Gene

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