MRPS25 Gene
protein-coding GIFtS: 48
GCID: GC03M015083
|
|
mitochondrial ribosomal protein S25
| |
Aliases
for MRPS25 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein S251 2 | | DKFZp313H08171 | | MRP-S251 2 3 | | FLJ000231 | | RPMS251 2 3 | | 28S Ribosomal Protein S25, Mitochondrial2 | | S25mt2 3 | | Mitochondrial 28S Ribosomal Protein S252 |
Export aliases for MRPS25 gene to outside databasesPrevious GC identifers: GC03M015019 GC03M015029 GC03M015065 |
Summaries
for MRPS25 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPS25:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein.A pseudogene corresponding to this gene is found on chromosome 4. (provided by RefSeq, Jul 2008)
Gene Wiki entry for MRPS25
|
Genomic Views
for MRPS25 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPS25 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 POU2F2 POU2F2C AREB6 POU2F1 POU2F1a POU2F2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPS25
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS25 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p25 Ensembl cytogenetic band: 3p25.1 HGNC cytogenetic band: 3p25MRPS25 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M015083: view genomic region
(about GC identifiers)
Start:
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15,083,967 bp from pter |
End:
|
15,106,842 bp from pter |
Size:
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22,876 bases |
Orientation:
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minus strand |
|
Proteins
for MRPS25 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RT25_HUMAN, P82663 (See
protein sequence)Recommended Name: 28S ribosomal protein S25, mitochondrial Size: 173 amino acids; 20116 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinctproteins
Subcellular location: Mitochondrion
Sequence caution: Sequence=BAB15723.1; Type=Erroneous initiation;
Secondary accessions: Q9H7P5Explore the universe of human proteins at neXtProt for MRPS25: NX_P82663
MRPS25 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_071942.1
ENSEMBL proteins: ENSP00000253686 ENSP00000390882 ENSP00000396828 ENSP00000407733 ENSP00000402068
Human Recombinant Protein Products for MRPS25:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
MRPS25 for ontologies About GeneDecksing
MRPS25 Antibody Products:
Assay Products for MRPS25: |
Protein
Domains /
Families
for MRPS25 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPS25 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P82663ProtoNet protein and cluster: P82663 1 Blocks protein family: IPB007741 Mitochondrial ribosome
UniProtKB/Swiss-Prot: RT25_HUMAN, P82663Similarity: Belongs to the ribosomal protein S25/L51 family |
Function
for MRPS25 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
NAS | -- |
MRPS25 for ontologies About GeneDecksing
Phenotypes:
1 MGI phenotypic allele  for Mrps25 (no phenotypes)
MRPS25 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS25 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS25
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRPS25 (NM_022497) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS25 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS25 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS25 |
|
Pathways & Interactions
for MRPS25 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS25
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
5/236 Interacting proteins for MRPS25 (P826632, 3 ENSP000002536864) via UniProtKB, MINT, STRING, and/or I2D (see all 236)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006412 | translation |
NAS | -- |
MRPS25 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRPS25 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPS25
Search CenterWatch for drugs/clinical trials and news about MRPS25 / RT25
|
Transcripts
for MRPS25 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPS25 gene: NM_022497.3 Unigene Cluster for MRPS25: Mitochondrial ribosomal protein S25 Hs.715617 [show with all ESTs]Unigene Representative Sequence: NM_0224977 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000496484 ENST00000474866 ENST00000253686(uc003bzl.3 uc011avl.2 uc011avm.1)
ENST00000449354 ENST00000420267 ENST00000444840 ENST00000447299
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS25 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS25
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRPS25 (NM_022497) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS25 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS25 |
Additional cDNA sequence: AK024433.1 AK024702.1 AK294123.1 AK298791.1 BC003590.2 19 DOTS entries: DT.444322 DT.120877745 DT.100662886 DT.99931950 DT.99985770 DT.92423867 DT.95102215 DT.100803869 DT.100702755 DT.99984153 DT.95102217 DT.100733205 DT.100748637 DT.86846935 DT.97837540 DT.100735538 DT.92449090 DT.92466510 DT.95138785 24/301 AceView cDNA sequences (see all 301): T29086 AL134751 AK024433 AA846344 AI421995 BE731211 BM474934 BU849441 BM271996 Z40764 BM975478 BU622373 H18888 CB108320 BE208522 BM674557 AA827163 BI964822 BM968375 BM555633 AI612794 CA411787 AL707226 AI858759
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS25 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | - | | - | | | | | | |
| SP4: | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | - | | | | | |
ECgene alternative splicing isoforms for MRPS25
|
Expression
for MRPS25 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPS25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCACATCA
About this image
See MRPS25 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPS25
SOURCE GeneReport for Unigene cluster: Hs.715617
SABiosciences Custom PCR Arrays for MRPS25
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS25
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPS25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS25 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS25 |
Orthologs
for MRPS25 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MRPS25 gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for MRPS25 (if available)
TreeFam Gene Tree for MRPS25 (if available) |
Paralogs
for MRPS25 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRPS25 gene
MRPS25 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for MRPS25
PGOHUM00000239496 PGOHUM00000245978
|
Genomic Variants
for MRPS25 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPS25 (15083967 - 15106842 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MRPS25
1 CNV: 3418 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS25 |
|
Disorders
/ Diseases
for MRPS25 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRPS25 for disorders About MalaCards
MRPS25 for disorders About GeneDecksing
OMIM gene information: 611987
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MRPS25 (1 document)
Export disorders for MRPS25 gene to outside databases
|
Publications
for MRPS25 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPS25 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with MRPS25) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 3 Koc E.C.... Spremulli L.L. (2001)
- Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)1, 2 Hattori A.... Ohara O. (2000)
- A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. (PubMed id 10938081)1, 2 Koc E.C....Spremulli L.L. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
|
External Searches for MRPS25 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPS25 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPS25 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPS25 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPS25 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRPS25 gene:
Search GeneIP for patents involving MRPS25
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPS25 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRPS25 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPS25 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS25 | | | OriGene Protein Over-expression Lysate for MRPS25 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRPS25 | | OriGene 3'-UTR Clone for MRPS25 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS25 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS25 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MRPS25 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPS25 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS25 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS25 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPS25 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS25 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS25 |
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 |  |  |  | |
| | | | Search Tocris compounds for MRPS25 |
| |  |  |  |  | | | | |
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 | | | MRPS25 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS25 |
|  |  |  |  | | | | ThermoFisher Antibody for MRPS25 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS25 |
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