MRPS25 Gene

Aliases
for MRPS25 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC03M015019 GC03M015029 GC03M015065

Summaries
for MRPS25 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for MRPS25 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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SwitchGear Promoter luciferase reporter plasmid: MRPS25 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRPS25

MRPS25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M015083:  view genomic region     (about GC identifiers)

Proteins
for MRPS25 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for MRPS25: NX_P82663

Explore proteomics data for MRPS25 at MOPED


See MRPS25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

MRPS25 Human Recombinant Protein Products:

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	antibodies-online proteins for MRPS25 (5 products)
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MRPS25 Antibody Products:

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MRPS25 Assay Products:

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	antibodies-online kits for MRPS25 (16 products)

Domains /
Families
for MRPS25 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: P82663

Find genes that share domains with MRPS25           About GenesLikeMe

Function
for MRPS25 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Gene Ontology (GO): 1 molecular function term:    About this table

genOway: Develop your customized and physiologically relevant rodent model for MRPS25

miRNA Products:		miRTarBase miRNAs that target MRPS25: hsa-mir-149-5p (MIRT045510), hsa-mir-16-5p (MIRT031700)
		Block miRNA regulation of human, mouse, rat MRPS25 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate MRPS25 (see all 92):
		hsa-miR-124* hsa-miR-520e hsa-miR-3152-3p hsa-miR-3607-3p hsa-miR-938 hsa-miR-30d hsa-miR-578 hsa-miR-1273d
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for MRPS25
		Predesigned siRNA for gene silencing in human, mouse, rat MRPS25

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for MRPS25

Clone Products:		OriGene clones in human, mouse for MRPS25 (see all 6) OriGene ORF clones in mouse, rat for MRPS25 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: MRPS25 (NM_022497)
		Sino Biological Human cDNA Clone for MRPS25
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRPS25
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS25

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for MRPS25
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS25

Localization
for MRPS25 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
mitochondrion	5
cytosol	3
extracellular	1
nucleus	1

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Gene Ontology (GO): 4 cellular component terms:    About this table

Pathways & Interactions
for MRPS25 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for MRPS25 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for MRPS25 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for MRPS25 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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MRPS25 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GAGCACATCA

About this image

Primer Products:		OriGene qPCR primer pairs and template standards for MRPS25 OriGene qSTAR qPCR primer pairs in human, mouse for MRPS25
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRPS25
		QuantiTect SYBR Green Assays in human, mouse, rat MRPS25
		QuantiFast Probe-based Assays in human, mouse, rat MRPS25

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS25

Orthologs
for MRPS25 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for MRPS25 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for MRPS25 gene

Find genes that share paralogs with MRPS25           About GenesLikeMe


2 Pseudogenes.org Pseudogenes for MRPS25
PGOHUM00000239496 PGOHUM00000245978

Genomic Variants
for MRPS25 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for MRPS25 (see all 350)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs584597131,2	C	--	15037113(+)	AAAAA-/A/AA           TGCAT	1	--	int1		1		NA	2
rs1429196871,2	C	--	15091515(+)	GAACAT/CGTTAT	1	--	ut31		1		EU	569
rs1885963541,2		--	15091661(+)	TACAGC/GGAACA	1	--	ut31		0	--	--	--	--
rs1466495591,2	C	--	15091708(+)	GCTGCC/TTGTGA	1	--	ut31		0	--	--	--	--
rs1907481011,2		--	15091841(+)	GTTATC/GTGTCC	1	--	ut31		0	--	--	--	--
rs793998401,2	C,F	--	15091949(+)	GGAAGG/CAATAC	1	--	ut31		1		WA	118
rs758606791,2	C,F	--	15092041(+)	AGCCCT/CTGCAG	1	--	ut31		1		WA	118
rs1831109521,2		--	15092059(+)	GAACGC/TCCAGG	1	--	ut31		0	--	--	--	--
rs622403971,2	C,F	--	15092073(+)	GTGGTA/GTCAAG	1	--	ut31		6		NA CSA WA	246
rs76405471,2	C,F,A,H	--	15092125(+)	GACATG/AGGAGG	1	--	ut31 ese3		9		NS EA NA	1088

HapMap Linkage Disequilibrium report for MRPS25 (15083967 - 15106842 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for MRPS25:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv834620	CNV	Gain	17160897
dgv1436e1	CNV	Complex	17122850

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing MRPS25

DNA2.0 Custom Variant and Variant Library Synthesis for MRPS25

Disorders / Diseases
for MRPS25 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for MRPS25 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for MRPS25 gene, integrated from 10 sources (see all 21): (articles sorted by number of sources associating them with MRPS25)

Utopia: connect your pdf to the dynamic world of online information

1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)^{1, 4} Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
4. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)^{1, 3} Koc E.C.... Spremulli L.L. (J. Biol. Chem. 2001)
5. Characterization of long cDNA clones from human adult spleen. (PubMed id 11214971)^{1, 2} Hattori A.... Ohara O. (DNA Res. 2000)
6. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. (PubMed id 10938081)^{1, 2} Koc E.C....Spremulli L.L. (J. Biol. Chem. 2000)
7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)¹ Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
8. p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability. (PubMed id 22904065)¹ Yagi M....Kang D. (Nucleic Acids Res. 2012)
9. A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (Cell 2012)
10. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

External Searches for MRPS25 gene

Genome Databases showing MRPS25 gene

Other Databases showing MRPS25 gene

Specialized Databases showing MRPS25 gene

Products
for MRPS25 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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