Aliases for MRPS25 Gene
Aliases for MRPS25 Gene
External Ids for MRPS25 Gene
- HGNC: 14511
- Entrez Gene: 64432
- Ensembl: ENSG00000131368
- OMIM: 611987
- UniProtKB: P82663
Previous GeneCards Identifiers for MRPS25 Gene
- GC03M015019
- GC03M015029
- GC03M015065
- GC03M015083
Summaries for MRPS25 Gene
-
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
GeneCards Summary for MRPS25 Gene
MRPS25 (Mitochondrial Ribosomal Protein S25) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation.
Additional gene information for MRPS25 Gene
No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS25 Gene
Genomics for MRPS25 Gene
GeneHancer (GH) Regulatory Elements for MRPS25 Gene
Regulatory Element Products
Genomic Locations for MRPS25 Gene
- chr3:15,042,251-15,065,335
- (GRCh38/hg38)
- Size:
- 23,085 bases
- Orientation:
- Minus strand
- chr3:15,083,967-15,106,842
- (GRCh37/hg19)
Genomic View for MRPS25 Gene
- Cytogenetic band:
-
- 3p25.1 by Ensembl
- 3p25.1 by Entrez Gene
- 3p25.1 by HGNC


RefSeq DNA sequence for MRPS25 Gene
Proteins for MRPS25 Gene
-
Protein details for MRPS25 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P82663-RT25_HUMAN
- Recommended name:
- 28S ribosomal protein S25, mitochondrial
- Protein Accession:
- P82663
- B4DFJ5
- B4DQG6
- Q9H7P5
Protein attributes for MRPS25 Gene
- Size:
- 173 amino acids
- Molecular mass:
- 20116 Da
- Quaternary structure:
-
- Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
- SequenceCaution:
-
- Sequence=BAB15723.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for MRPS25 Gene
Post-translational modifications for MRPS25 Gene
Other Protein References for MRPS25 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for MRPS25
- Novus Biologicals Antibodies for MRPS25
- Invitrogen Antibodies for MRPS25
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-
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Protein Products
-
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-
Quality Products:
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-
Abcam proteins for MRPS25
Assay Products
No data available for DME Specific Peptides for MRPS25 Gene
Domains & Families for MRPS25 Gene
Gene Families for MRPS25 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Ribosomal proteins
Protein Domains for MRPS25 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for MRPS25 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P82663UniProtKB/Swiss-Prot:
RT25_HUMAN :- Belongs to the mitochondrion-specific ribosomal protein mS25 family.
- Family:
-
- Belongs to the mitochondrion-specific ribosomal protein mS25 family.
Function for MRPS25 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003735 | structural constituent of ribosome | IBA | -- |
Phenotypes for MRPS25 Gene
- MGI mutant phenotypes for MRPS25:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for MRPS25:
Animal Models for MRPS25 Gene
- MGI Knock Outs for MRPS25:
-
- Mrps25 tm1.1(KOMP)Vlcg
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for MRPS25 gene
-
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CRISPR Products
-
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-
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-
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miRNA for MRPS25 Gene
- miRTarBase miRNAs that target MRPS25
-
- hsa-mir-16-5p (MIRT031700)
- hsa-mir-149-5p (MIRT045510)
- hsa-mir-150-3p (MIRT498129)
- hsa-mir-7108-5p (MIRT701795)
- hsa-mir-433-3p (MIRT701796)
- hsa-mir-653-3p (MIRT701797)
- hsa-mir-4420 (MIRT701798)
- hsa-mir-181b-3p (MIRT701799)
- hsa-mir-181b-2-3p (MIRT701800)
- hsa-mir-663b (MIRT701801)
- hsa-mir-143-5p (MIRT701802)
- hsa-mir-4430 (MIRT701803)
- hsa-mir-3652 (MIRT701804)
- hsa-mir-7155-3p (MIRT701805)
- hsa-mir-3136-3p (MIRT701806)
- hsa-mir-122-5p (MIRT701807)
- hsa-mir-504-3p (MIRT701808)
- hsa-mir-3135b (MIRT701809)
- hsa-mir-6890-3p (MIRT701810)
- hsa-mir-509-5p (MIRT701811)
- hsa-mir-509-3-5p (MIRT701812)
- hsa-mir-4418 (MIRT701813)
miRNA Products
- Search ViGene Biosciences for MRPS25
Inhibitory RNA Products
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-
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Clone Products
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-
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MRPS25 gene related products
- orf clones - Search results for available MRPS25 gene related products
- Applied Biological Materials Clones for MRPS25
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for MRPS25 gene
-
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-
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No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRPS25 Gene
Localization for MRPS25 Gene
Subcellular locations from UniProtKB/Swiss-Prot for MRPS25 Gene
- Mitochondrion.
- Mitochondria (4)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IDA,IBA | -- |
GO:0005743 | mitochondrial inner membrane | TAS | -- |
GO:0005840 | ribosome | IEA | -- |
GO:0030529 | intracellular ribonucleoprotein complex | IEA | -- |
Pathways & Interactions for MRPS25 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Mitochondrial translation | ||
2 | Organelle biogenesis and maintenance |
Pathways by source for MRPS25 Gene
Interacting Proteins for MRPS25 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0070125 | mitochondrial translational elongation | TAS | -- |
GO:0070126 | mitochondrial translational termination | TAS | -- |
No data available for SIGNOR curated interactions for MRPS25 Gene
Transcripts for MRPS25 Gene
mRNA/cDNA for MRPS25 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (301) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for MRPS25 Gene
CRISPR Products
-
OriGene CRISPR knockouts for MRPS25
- genomics-online: gRNA clones - Search results for available MRPS25 gene related products
- Applied Biological Materials CRISPR for MRPS25
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for MRPS25
- GenScript: Design CRISPR guide RNA sequences for MRPS25
miRNA Products
- Search ViGene Biosciences for MRPS25
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for MRPS25
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- genomics-online: shRNA clones - Search results for available MRPS25 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for MRPS25 gene
Clone Products
- Sino Biological Human cDNA Clone for MRPS25
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- VectorBuilder custom plasmid, inducible vectors for MRPS25
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MRPS25
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available MRPS25 gene related products
- orf clones - Search results for available MRPS25 gene related products
- Applied Biological Materials Clones for MRPS25
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||
SP2: | |||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||
SP4: | - | - | |||||||||||||||||||
SP5: | - | - | - | - | - |
Expression for MRPS25 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS25 Gene
NURSA nuclear receptor signaling pathways regulating expression of MRPS25 Gene:
MRPS25SOURCE GeneReport for Unigene cluster for MRPS25 Gene:
Hs.715617Evidence on tissue expression from TISSUES for MRPS25 Gene
- Nervous system(4.8)
- Spleen(4.3)
- Lung(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for MRPS25
-
OriGene qPCR primer pairs for MRPS25
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS25 Gene
Orthologs for MRPS25 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | MRPS25 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | MRPS25 33 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | MRPS25 34 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Mrps25 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Mrps25 33 |
|
||
cow (Bos Taurus) |
Mammalia | MRPS25 34 33 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | MRPS25 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | MRPS25 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | MRPS25 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100494871 33 |
|
||
Str.9548 33 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.6869 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | mrps25 33 34 |
|
||
rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.11135 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | mRpS25 35 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP012136 33 |
|
||
worm (Caenorhabditis elegans) |
Secernentea | mrps-25 33 34 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.4960 34 |
|
OneToOne |
- Species where no ortholog for MRPS25 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for MRPS25 Gene
Pseudogenes.org Pseudogenes for MRPS25 Gene
No data available for Paralogs for MRPS25 Gene
Variants for MRPS25 Gene
SNP ID | Clin | Chr 03 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000017575 | -- | 15,042,951(-) | C/T | genic_downstream_transcript_variant, non_coding_transcript_variant | |
rs1000050366 | -- | 15,058,703(-) | T/G | intron_variant | |
rs1000267875 | -- | 15,063,525(-) | A/G | intron_variant | |
rs1000498217 | -- | 15,044,423(-) | T/C | genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant | |
rs1000550003 | -- | 15,051,978(-) | A/G | 3_prime_UTR_variant, non_coding_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv4687n100 | CNV | gain | 25217958 |
esv2759130 | CNV | gain | 17122850 |
nsv834620 | CNV | gain | 17160897 |
Additional Variant Information for MRPS25 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- MRPS25
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS25 Gene
Disorders for MRPS25 Gene
Additional Disease Information for MRPS25
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for MRPS25 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS25 Gene
Publications for MRPS25 Gene
- Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 2 3 58
- A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. (PMID: 10938081) Koc EC … Spremulli LL (The Journal of biological chemistry 2000) 3 4 58
Products for MRPS25 Gene
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- Invitrogen Antibodies for MRPS25
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for MRPS25
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 65 available MRPS25 Antibodies ranked by validation data
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- antibodies-online: Search results for 7 available MRPS25 Proteins ranked by validation data
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- ViGene Biosciences adenoviral particle packaged cDNA for MRPS25 gene
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Sources for MRPS25 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
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