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Aliases for MRPS25 Gene

Aliases for MRPS25 Gene

  • Mitochondrial Ribosomal Protein S25 2 3 5
  • Mitochondrial 28S Ribosomal Protein S25 2 3
  • MRP-S25 3 4
  • RPMS25 3 4
  • S25mt 3 4

External Ids for MRPS25 Gene

Previous GeneCards Identifiers for MRPS25 Gene

  • GC03M015019
  • GC03M015029
  • GC03M015065
  • GC03M015083

Summaries for MRPS25 Gene

Entrez Gene Summary for MRPS25 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for MRPS25 Gene

MRPS25 (Mitochondrial Ribosomal Protein S25) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance.

Gene Wiki entry for MRPS25 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS25 Gene

Genomics for MRPS25 Gene

Regulatory Elements for MRPS25 Gene

Enhancers for MRPS25 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPS25 on UCSC Golden Path with GeneCards custom track

Promoters for MRPS25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPS25 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPS25 Gene

15,042,251 bp from pter
15,065,335 bp from pter
23,085 bases
Minus strand

Genomic View for MRPS25 Gene

Genes around MRPS25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS25 Gene

Proteins for MRPS25 Gene

  • Protein details for MRPS25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S25, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B4DFJ5
    • B4DQG6
    • Q9H7P5

    Protein attributes for MRPS25 Gene

    173 amino acids
    Molecular mass:
    20116 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
    • Sequence=BAB15723.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS25 Gene

    Alternative splice isoforms for MRPS25 Gene


neXtProt entry for MRPS25 Gene

Proteomics data for MRPS25 Gene at MOPED

Post-translational modifications for MRPS25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS25 Gene

No data available for DME Specific Peptides for MRPS25 Gene

Domains & Families for MRPS25 Gene

Gene Families for MRPS25 Gene

Protein Domains for MRPS25 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S25/L51 family.
  • Belongs to the ribosomal protein S25/L51 family.
genes like me logo Genes that share domains with MRPS25: view

Function for MRPS25 Gene

genes like me logo Genes that share phenotypes with MRPS25: view

Animal Models for MRPS25 Gene

MGI Knock Outs for MRPS25:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRPS25 Gene

Localization for MRPS25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS25 Gene


Subcellular locations from

Jensen Localization Image for MRPS25 Gene COMPARTMENTS Subcellular localization image for MRPS25 gene
Compartment Confidence
mitochondrion 5
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPS25: view

Pathways & Interactions for MRPS25 Gene

genes like me logo Genes that share pathways with MRPS25: view

Gene Ontology (GO) - Biological Process for MRPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPS25: view

No data available for SIGNOR curated interactions for MRPS25 Gene

Drugs & Compounds for MRPS25 Gene

No Compound Related Data Available

Transcripts for MRPS25 Gene

Unigene Clusters for MRPS25 Gene

Mitochondrial ribosomal protein S25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS25 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: -
SP3: - - -
SP4: - -
SP5: - - - - -

Relevant External Links for MRPS25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS25 Gene

mRNA expression in normal human tissues for MRPS25 Gene

Protein differential expression in normal tissues from HIPED for MRPS25 Gene

This gene is overexpressed in Lung (30.5) and Pancreas (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS25 Gene

SOURCE GeneReport for Unigene cluster for MRPS25 Gene Hs.715617

genes like me logo Genes that share expression patterns with MRPS25: view

Protein tissue co-expression partners for MRPS25 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS25 Gene

Orthologs for MRPS25 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS25 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS25 35
  • 84.39 (n)
  • 88.44 (a)
MRPS25 36
  • 88 (a)
(Canis familiaris)
Mammalia MRPS25 35
  • 89.21 (n)
  • 90.75 (a)
MRPS25 36
  • 91 (a)
(Mus musculus)
Mammalia Mrps25 35
  • 85.77 (n)
  • 89.47 (a)
Mrps25 16
Mrps25 36
  • 89 (a)
(Pan troglodytes)
Mammalia MRPS25 35
  • 99.42 (n)
  • 100 (a)
MRPS25 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrps25 35
  • 85.38 (n)
  • 88.3 (a)
(Monodelphis domestica)
Mammalia MRPS25 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS25 36
  • 86 (a)
(Gallus gallus)
Aves MRPS25 35
  • 72.9 (n)
  • 80.12 (a)
MRPS25 36
  • 74 (a)
(Anolis carolinensis)
Reptilia MRPS25 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494871 35
  • 70.74 (n)
  • 79.65 (a)
Str.9548 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6869 35
(Danio rerio)
Actinopterygii mrps25 35
  • 71.87 (n)
  • 73.99 (a)
mrps25 36
  • 74 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11135 35
fruit fly
(Drosophila melanogaster)
Insecta mRpS25 37
  • 54 (a)
mRpS25 35
  • 61.18 (n)
  • 55.49 (a)
mRpS25 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012136 35
  • 60.98 (n)
  • 57.32 (a)
(Caenorhabditis elegans)
Secernentea mrps-25 35
  • 49.79 (n)
  • 40.74 (a)
mrps-25 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4960 36
  • 32 (a)
Species with no ortholog for MRPS25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS25 Gene

Gene Tree for MRPS25 (if available)
Gene Tree for MRPS25 (if available)

Paralogs for MRPS25 Gene Pseudogenes for MRPS25 Gene

genes like me logo Genes that share paralogs with MRPS25: view

No data available for Paralogs for MRPS25 Gene

Variants for MRPS25 Gene

Sequence variations from dbSNP and Humsavar for MRPS25 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs12497 -- 15,052,554(+) CTCCC(A/G)CAGGC intron-variant, nc-transcript-variant, reference, missense
rs2276753 -- 15,065,004(-) GCCTG(A/C)TGGTA intron-variant
rs2343627 -- 15,061,985(+) cagcc(A/G)ccccg intron-variant
rs540600 -- 15,054,965(-) agaac(C/T)atgag intron-variant
rs9812765 -- 15,052,844(+) ACACC(A/G)CAGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS25 Gene

Variant ID Type Subtype PubMed ID
dgv1436e1 CNV Complex 17122850
nsv834620 CNV Gain 17160897

Variation tolerance for MRPS25 Gene

Residual Variation Intolerance Score: 76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRPS25 Gene

Disorders for MRPS25 Gene

Relevant External Links for MRPS25

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPS25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS25 Gene

Publications for MRPS25 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3

Products for MRPS25 Gene

Sources for MRPS25 Gene