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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRPS24 Gene

protein-coding   GIFtS: 49
GCID: GC07M043872

mitochondrial ribosomal protein S24
  Search for MRPS24
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for MRPS24    

Aliases
for MRPS24 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Mitochondrial Ribosomal Protein S241 2     BMRP471
MRP-S241 2 3     HSPC3351
S24mt2 3     28S Ribosomal Protein S24, Mitochondrial2
BMRP-471     Mitochondrial 28S Ribosomal Protein S242

External Ids:    HGNC: 145101   Entrez Gene: 649512   Ensembl: ENSG000000625827   OMIM: 6119865   UniProtKB: Q96EL23   

Export aliases for MRPS24 gene to outside databases

Previous GC identifers: GC07M043552 GC07M043646 GC07M043679 GC07M043791


Summaries
for MRPS24 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for MRPS24:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They
have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.
Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.
Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in
biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein.
A pseudogene corresponding to this gene is found on chromosome 11. Read-through transcription exists between this gene
and the upstream upregulator of cell proliferation (URGCP) gene. (provided by RefSeq, Mar 2011)

Gene Wiki entry for MRPS24


Genomic Views
for MRPS24 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRPS24 gene promoter:
         AhR   GR   RP58   AML1a   p53   Olf-1   Arnt   E47   Hand1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: MRPS24 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRPS24

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS24


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p14

MRPS24 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPS24 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M043872:  view genomic region     (about GC identifiers)

Start:
 43,906,157 bp from pter      End:
 43,909,492 bp from pter
Size:
 3,336 bases      Orientation:
 minus strand

1 alternative location:
Chr7-,CRA_TCAG 43,945,658-43,948,645     

Proteins
for MRPS24 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RT24_HUMAN, Q96EL2 (See protein sequence)
Recommended Name: 28S ribosomal protein S24, mitochondrial precursor  
Size: 167 amino acids; 19015 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct
proteins (By similarity)
Subcellular location: Mitochondrion (By similarity)
Sequence caution: Sequence=AAF29013.1; Type=Frameshift; Positions=27, 45;
Secondary accessions: A4D1U9 P82668 Q96Q23 Q9P047

Explore the universe of human proteins at neXtProt for MRPS24: NX_Q96EL2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96EL2

    • MRPS24 Protein expression data from MOPED and PaxDb:    About this image 
    MRPS24 Protein Expression
    REFSEQ proteins: NP_114403.1  
    ENSEMBL proteins: 
     ENSP00000318158   ENSP00000407625   ENSP00000409298  

    Human Recombinant Protein Products for MRPS24: 
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    Novus Biologicals MRPS24 Protein
    Novus Biologicals MRPS24 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for MRPS24

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005762mitochondrial large ribosomal subunit ISS--
    GO:0005763mitochondrial small ribosomal subunit NAS10938081

    MRPS24 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for MRPS24 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    MRPS24 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026146 MRPS24

    Graphical View of Domain Structure for InterPro Entry Q96EL2

    ProtoNet protein and cluster: Q96EL2


    Function
    for MRPS24 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003735structural constituent of ribosome ISS--
         
    MRPS24 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    hsa-let-7b (MIRT001615)

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    Inhib. RNA
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    In Situ Assay
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    Pathways & Interactions
    for MRPS24 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS24

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/234 Interacting proteins for MRPS24 (Q96EL22, 3 ENSP000003181584) via UniProtKB, MINT, STRING, and/or I2D (see all 234)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    DDX56Q9NY933, ENSP000002587724I2D: score=2 STRING: ENSP00000258772
    RABGGTBP536113I2D: score=5 
    KBTBD7Q8WVZ93I2D: score=1 
    AARS2Q5JTZ92MINT-8079030
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation ISS--
    GO:0008150biological_process ND--

    MRPS24 for ontologies           About GeneDecksing



    Drugs & Compounds
    for MRPS24 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRPS24
    Search CenterWatch for drugs/clinical trials and news about MRPS24 / RT24 

    Transcripts
    for MRPS24 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for MRPS24 gene: 
    NM_032014.2  

    Unigene Cluster for MRPS24:

    Mitochondrial ribosomal protein S24
    Hs.284286  [show with all ESTs]
    Unigene Representative Sequence: AK054982
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000317534(uc003tit.1 uc022acg.1) ENST00000418740 ENST00000483330
    ENST00000467084 ENST00000414932

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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF161453.1 AK054982.1 BC012167.1 BC054865.1 

    12 DOTS entries:

    DT.449892  DT.100754594  DT.40272684  DT.100754593  DT.91865676  DT.121041196  DT.95344454  DT.121040847 
    DT.86995046  DT.86999970  DT.435569  DT.91829646 

    24/106 AceView cDNA sequences (see all 106):

    AW117562 BC012167 CA448635 CA413186 AI870515 BU688746 BE382386 AI718892 
    BM708786 NM_032014 BM686963 CB123663 AA978346 BQ670843 AI653972 BF727299 
    BX283917 BG482320 BM314383 AA702159 BF970023 CA441208 CA309904 AA062817 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS24    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
    SP1:              -     -                 -                     
    SP2:                                      -                     
    SP3:                                      -                     
    SP4:                                                            


    ECgene alternative splicing isoforms for MRPS24

    Expression
    for MRPS24 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRPS24 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGGGTACCT
    MRPS24 Expression
    About this image
    See MRPS24 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRPS24

    SOURCE GeneReport for Unigene cluster: Hs.284286
        SABiosciences Custom PCR Arrays for MRPS24

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    In Situ
    Assay Products:     
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    Orthologs
    for MRPS24 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for MRPS24 gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Mrps241 , 5 mitochondrial ribosomal protein S241, 5 84.43(n)1
    83.83(a)1    		   11 (3.87 cM)5
    646601  NM_026080.21  NP_080356.11 
     57039835 
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.179332 Xenopus laevis transcribed sequence with weak similarity to protein refNP_114403.1 (H.sapiens) mitochondrial ribosomal protein S24; mitochondrial 28S ribosomal protein S24 [Homo sapiens] less 73.26(n)    BX844293.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.150622 Transcribed sequence with weak similarity to protein refNP_114403.1 (H.sapiens) mitochondrial ribosomal protein S24; mitochondrial 28S ribosomal protein S24 [Homo sapiens] less 70.09(n)    BM184337.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta mRpS241 , 3 protein biosynthesis structural constituent
    of ribosome less3
    mitochondrial ribosomal protein S241    		 42(a)3
    53.96(n)1
    43.88(a)1    		   95E63
    428701  NM_079752.21  NP_524476.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea mrps-241 Protein MRPS-24 45.07(n)
    36.62(a)    		   259579  NM_001028005.3  NP_001023176.1 


    ENSEMBL Gene Tree for MRPS24 (if available)
    TreeFam Gene Tree for MRPS24 (if available) 

    Paralogs
    for MRPS24 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRPS24 gene

    MRPS24 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MRPS24
    PGOHUM00000242111


    Genomic Variants
    for MRPS24 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/106 NCBI SNPs in MRPS24 are shown (see all 106)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs105587461,2
    		C--43905658(+) TCTTGCT/-CTGTC 2 -- ds5001 int11Minor allele frequency- -:0.50CSA 2
    rs1115150361,2
    		C--43905660(+) TTGCTC/GTGTCA 2 -- ds5001 int10--------
    rs1427619871,2
    		--43905712(+) GCTCCA/GCCTCT 2 -- ds5001 int10--------
    rs26903871,2
    		C,F,A,H--43905719(-) GAACTC/TGAGAG 2 -- ds5001 int115Minor allele frequency- T:0.47NA NS EA WA CSA 790
    rs1857160481,2
    		--43905770(+) ACAGAC/TGCCCG 2 -- ds5001 int10--------
    rs1137213641,2
    		--43905774(+) ACGCCC/TGCCAC 2 -- int1 ds50011Minor allele frequency- T:0.50CSA 2
    rs102545701,2
    		C--43905815(+) agagaC/Tggggt 2 -- ds5001 int10--------
    rs1502159171,2
    		--43905904(+) ACAGGC/TGTGAG 2 -- ds5001 int10--------
    rs6732861,2
    		C--43905910(-) CGGTGG/ACTCAC 2 -- int1 ds50019Minor allele frequency- A:0.00NA WA CSA 15
    rs1403404021,2
    		--43906072(+) CTGGCA/GTCAGC 2 -- ds5001 int10--------

    HapMap Linkage Disequilibrium report for MRPS24 (43906157 - 43909492 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for MRPS24
         1 CNV: 4531

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    Disorders / Diseases
    for MRPS24 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    MRPS24 for disorders           About MalaCards

    MRPS24 for disorders           About GeneDecksing

    OMIM gene information: 611986    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: MRPS24 (1 document)

    Export disorders for MRPS24 gene to outside databases

    Publications
    for MRPS24 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRPS24 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with MRPS24)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of the mouse ribosomal protein S24 multigene family: a uniquely expressed intron-containing gene with cell-specific expression of three alternatively spliced mRNAs. (PubMed id 8127713)1, 3, 9 Xu L....Ro H.S. (1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    4. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041)1, 2 Suzuki T....Watanabe K. (2001)
    5. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2 Kenmochi N....Tanaka T. (2001)
    6. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 3 Koc E.C.... Spremulli L.L. (2001)
    7. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. (PubMed id 10938081)1, 2 Koc E.C....Spremulli L.L. (2000)
    8. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2 Mao M.... Chen Z. (1998)
    9. Biochemical and computational analysis of LNX1 interac ting proteins. (PubMed id 22087225)1 Wolting C.D....McGlade C.J. (2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for MRPS24 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing MRPS24 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64951 HGNC: 14510 AceView: MRPS24 Ensembl:ENSG00000062582 euGenes: HUgn64951
    ECgene: MRPS24 H-InvDB: MRPS24

    Other Databases showing MRPS24 gene

    (According to HUGE)
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    Specialized Databases showing MRPS24 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRPS24 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for MRPS24 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    		Patent Information for MRPS24 gene:
    Search GeneIP for patents involving MRPS24

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