Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPS23 Gene

Aliases for MRPS23 Gene

  • Mitochondrial Ribosomal Protein S23 2 3 5
  • MRP-S23 3 4
  • S23mt 3 4
  • 28S Ribosomal Protein S23, Mitochondrial 3
  • CGI-138 3
  • HSPC329 3

External Ids for MRPS23 Gene

Previous GeneCards Identifiers for MRPS23 Gene

  • GC17M055658
  • GC17M058398
  • GC17M056255
  • GC17M056391
  • GC17M053271
  • GC17M055916
  • GC17M051277

Summaries for MRPS23 Gene

Entrez Gene Summary for MRPS23 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 7p. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS23 Gene

MRPS23 (Mitochondrial Ribosomal Protein S23) is a Protein Coding gene. Diseases associated with MRPS23 include Mitochondrial Disorders. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS23 Gene

Genomics for MRPS23 Gene

Regulatory Elements for MRPS23 Gene

Enhancers for MRPS23 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MRPS23 on UCSC Golden Path with GeneCards custom track

Promoters for MRPS23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPS23 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPS23 Gene

Chromosome:
17
Start:
57,834,781 bp from pter
End:
57,850,072 bp from pter
Size:
15,292 bases
Orientation:
Minus strand

Genomic View for MRPS23 Gene

Genes around MRPS23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS23 Gene

Proteins for MRPS23 Gene

  • Protein details for MRPS23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3D9-RT23_HUMAN
    Recommended name:
    28S ribosomal protein S23, mitochondrial
    Protein Accession:
    Q9Y3D9
    Secondary Accessions:
    • B2R6V3
    • Q96Q24
    • Q9BWH8
    • Q9P053

    Protein attributes for MRPS23 Gene

    Size:
    190 amino acids
    Molecular mass:
    21771 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
    SequenceCaution:
    • Sequence=AAD34133.1; Type=Frameshift; Positions=138; Evidence={ECO:0000305}; Sequence=AAF29007.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS23 Gene

neXtProt entry for MRPS23 Gene

Post-translational modifications for MRPS23 Gene

  • Ubiquitination at Lys 57
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS23 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS23 Gene

Domains & Families for MRPS23 Gene

Gene Families for MRPS23 Gene

Protein Domains for MRPS23 Gene

Suggested Antigen Peptide Sequences for MRPS23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPS23: view

No data available for UniProtKB/Swiss-Prot for MRPS23 Gene

Function for MRPS23 Gene

Gene Ontology (GO) - Molecular Function for MRPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 24965446
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPS23: view

Phenotypes for MRPS23 Gene

GenomeRNAi human phenotypes for MRPS23:
genes like me logo Genes that share phenotypes with MRPS23: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS23 Gene

Localization for MRPS23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS23 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS23 Gene COMPARTMENTS Subcellular localization image for MRPS23 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MRPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
GO:0031965 nuclear membrane IDA --
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with MRPS23: view

Pathways & Interactions for MRPS23 Gene

genes like me logo Genes that share pathways with MRPS23: view

Gene Ontology (GO) - Biological Process for MRPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS23: view

No data available for SIGNOR curated interactions for MRPS23 Gene

Drugs & Compounds for MRPS23 Gene

No Compound Related Data Available

Transcripts for MRPS23 Gene

mRNA/cDNA for MRPS23 Gene

Unigene Clusters for MRPS23 Gene

Mitochondrial ribosomal protein S23:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS23 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2:
SP3: -

Relevant External Links for MRPS23 Gene

GeneLoc Exon Structure for
MRPS23
ECgene alternative splicing isoforms for
MRPS23

Expression for MRPS23 Gene

mRNA expression in normal human tissues for MRPS23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS23 Gene

This gene is overexpressed in Tlymphocyte (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS23 Gene



Protein tissue co-expression partners for MRPS23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS23 Gene:

MRPS23

SOURCE GeneReport for Unigene cluster for MRPS23 Gene:

Hs.5836
genes like me logo Genes that share expression patterns with MRPS23: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS23 Gene

Orthologs for MRPS23 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS23 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPS23 34
  • 86.32 (n)
  • 82.11 (a)
MRPS23 35
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS23 34
  • 86.14 (n)
  • 82.63 (a)
MRPS23 35
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrps23 34
  • 82.8 (n)
  • 82.17 (a)
Mrps23 16
Mrps23 35
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPS23 34
  • 99.65 (n)
  • 99.47 (a)
MRPS23 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps23 34
  • 79.1 (n)
  • 73.45 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPS23 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS23 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS23 34
  • 58.19 (n)
  • 54.8 (a)
MRPS23 35
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPS23 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps23 34
  • 56.08 (n)
  • 57.06 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30006 34
zebrafish
(Danio rerio)
Actinopterygii mrps23 34
  • 58.13 (n)
  • 53.57 (a)
mrps23 35
  • 44 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002893 34
  • 52.8 (n)
  • 45.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS23 34
  • 52.62 (n)
  • 44.63 (a)
mRpS23 35
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrps-23 35
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToOne
Species where no ortholog for MRPS23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS23 Gene

ENSEMBL:
Gene Tree for MRPS23 (if available)
TreeFam:
Gene Tree for MRPS23 (if available)

Paralogs for MRPS23 Gene

Pseudogenes.org Pseudogenes for MRPS23 Gene

genes like me logo Genes that share paralogs with MRPS23: view

No data available for Paralogs for MRPS23 Gene

Variants for MRPS23 Gene

Sequence variations from dbSNP and Humsavar for MRPS23 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2586037 -- 57,838,804(+) TGAGA(C/G)CATAC downstream-variant-500B
rs2586038 -- 57,839,280(+) AAAGC(G/T)CAAGT utr-variant-3-prime
rs2586039 -- 57,842,221(+) gttgc(C/T)caggc intron-variant
rs2586040 -- 57,842,889(+) atata(C/T)ataca intron-variant
rs2586041 -- 57,842,939(+) acGag(C/G)caggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS23 Gene

Variant ID Type Subtype PubMed ID
esv3307805 CNV mobile element insertion 20981092
esv3387547 CNV insertion 20981092
nsv819589 CNV loss 19587683

Variation tolerance for MRPS23 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS23 Gene

Human Gene Mutation Database (HGMD)
MRPS23
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS23 Gene

Disorders for MRPS23 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MRPS23 Gene - From: GeneCards

Disorder Aliases PubMed IDs
mitochondrial disorders
  • mitochondrial encephalomyopathies
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

RT23_HUMAN
  • Note=Defects in MRPS23 may play a role in mitochondrial disorders characterized by combined respiratory chain complex deficiencies. {ECO:0000269 PubMed:26741492}.

Relevant External Links for MRPS23

Genetic Association Database (GAD)
MRPS23
Human Genome Epidemiology (HuGE) Navigator
MRPS23
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS23
genes like me logo Genes that share disorders with MRPS23: view

No data available for Genatlas for MRPS23 Gene

Publications for MRPS23 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 65
  5. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 3 4 65

Products for MRPS23 Gene

Sources for MRPS23 Gene

Content