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Aliases for MRPS23 Gene

Aliases for MRPS23 Gene

  • Mitochondrial Ribosomal Protein S23 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein MS23 3 4
  • MRP-S23 3 4
  • S23mt 3 4
  • 28S Ribosomal Protein S23, Mitochondrial 3
  • CGI-138 3
  • HSPC329 3

External Ids for MRPS23 Gene

Previous GeneCards Identifiers for MRPS23 Gene

  • GC17M055658
  • GC17M058398
  • GC17M056255
  • GC17M056391
  • GC17M053271
  • GC17M055916
  • GC17M051277

Summaries for MRPS23 Gene

Entrez Gene Summary for MRPS23 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 7p. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS23 Gene

MRPS23 (Mitochondrial Ribosomal Protein S23) is a Protein Coding gene. Diseases associated with MRPS23 include Mitochondrial Disorders. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Additional gene information for MRPS23 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS23 Gene

Genomics for MRPS23 Gene

GeneHancer (GH) Regulatory Elements for MRPS23 Gene

Promoters and enhancers for MRPS23 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I057848 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 555.5 -1.6 -1632 6 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 MRPS23 PIR35014 SRSF1 MKS1 COIL ENSG00000262298 VEZF1 CUEDC1 SUPT4H1 GC17P057856
GH17I057872 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.9 -25.0 -24994 4.9 HDGF PKNOX1 MLX ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B CUEDC1 MRPS23 MKS1 SRSF1 TSPOAP1 GC17P057856 ENSG00000264914
GH17I057935 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -86.5 -86549 4 HDGF FOXA2 MLX ARID4B NEUROD1 SIN3A ZBTB7B ZNF48 ETS1 ZNF121 MRPS23 EPX MKS1 CUEDC1 ENSG00000264914 GC17M057928
GH17I057993 Enhancer 1.4 Ensembl ENCODE dbSUPER 11.6 -144.6 -144598 2.9 HNRNPUL1 CLOCK FOXA2 ARID4B SIN3A ZNF2 ZBTB7B ZNF48 POLR2B ARID2 ENSG00000264112 SRSF1 MKS1 VEZF1 CUEDC1 MRPS23 LOC101927666 ENSG00000266086 GC17M057928
GH17I057877 Enhancer 1.3 Ensembl ENCODE dbSUPER 12 -30.6 -30559 5.4 FOXA2 ZFP64 ARID4B SIN3A DMAP1 GLIS2 FOS SP5 ZC3H11A MXD4 SRSF1 MKS1 COIL ENSG00000262298 CUEDC1 VEZF1 MRPS23 RAD51C GC17P057856 ENSG00000264914
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MRPS23 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPS23 gene promoter:

Genomic Locations for MRPS23 Gene

Genomic Locations for MRPS23 Gene
chr17:57,834,781-57,850,072
(GRCh38/hg38)
Size:
15,292 bases
Orientation:
Minus strand
chr17:55,916,287-55,927,433
(GRCh37/hg19)

Genomic View for MRPS23 Gene

Genes around MRPS23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS23 Gene

Proteins for MRPS23 Gene

  • Protein details for MRPS23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3D9-RT23_HUMAN
    Recommended name:
    28S ribosomal protein S23, mitochondrial
    Protein Accession:
    Q9Y3D9
    Secondary Accessions:
    • B2R6V3
    • Q96Q24
    • Q9BWH8
    • Q9P053

    Protein attributes for MRPS23 Gene

    Size:
    190 amino acids
    Molecular mass:
    21771 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
    SequenceCaution:
    • Sequence=AAD34133.1; Type=Frameshift; Positions=138; Evidence={ECO:0000305}; Sequence=AAF29007.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS23 Gene

neXtProt entry for MRPS23 Gene

Post-translational modifications for MRPS23 Gene

Other Protein References for MRPS23 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS23 Gene

Domains & Families for MRPS23 Gene

Gene Families for MRPS23 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPS23 Gene

Suggested Antigen Peptide Sequences for MRPS23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3D9

UniProtKB/Swiss-Prot:

RT23_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mS23 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mS23 family.
genes like me logo Genes that share domains with MRPS23: view

Function for MRPS23 Gene

Phenotypes From GWAS Catalog for MRPS23 Gene

Gene Ontology (GO) - Molecular Function for MRPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 24965446
genes like me logo Genes that share ontologies with MRPS23: view

Phenotypes for MRPS23 Gene

GenomeRNAi human phenotypes for MRPS23:
genes like me logo Genes that share phenotypes with MRPS23: view

miRNA for MRPS23 Gene

miRTarBase miRNAs that target MRPS23

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS23 Gene

Localization for MRPS23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS23 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS23 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Nuclear membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MRPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with MRPS23: view

Pathways & Interactions for MRPS23 Gene

genes like me logo Genes that share pathways with MRPS23: view

Gene Ontology (GO) - Biological Process for MRPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS23: view

No data available for SIGNOR curated interactions for MRPS23 Gene

Drugs & Compounds for MRPS23 Gene

No Compound Related Data Available

Transcripts for MRPS23 Gene

mRNA/cDNA for MRPS23 Gene

Unigene Clusters for MRPS23 Gene

Mitochondrial ribosomal protein S23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS23 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2:
SP3: -

Relevant External Links for MRPS23 Gene

GeneLoc Exon Structure for
MRPS23
ECgene alternative splicing isoforms for
MRPS23

Expression for MRPS23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS23 Gene

This gene is overexpressed in Tlymphocyte (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS23 Gene



Protein tissue co-expression partners for MRPS23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS23 Gene:

MRPS23

SOURCE GeneReport for Unigene cluster for MRPS23 Gene:

Hs.5836

Evidence on tissue expression from TISSUES for MRPS23 Gene

  • Eye(4.3)
  • Blood(4.1)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with MRPS23: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS23 Gene

Orthologs for MRPS23 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS23 33 34
  • 99.65 (n)
cow
(Bos Taurus)
Mammalia MRPS23 34 33
  • 86.32 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS23 33 34
  • 86.14 (n)
mouse
(Mus musculus)
Mammalia Mrps23 33 16 34
  • 82.8 (n)
rat
(Rattus norvegicus)
Mammalia Mrps23 33
  • 79.1 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPS23 34
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS23 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS23 33 34
  • 58.19 (n)
lizard
(Anolis carolinensis)
Reptilia MRPS23 34
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps23 33
  • 56.08 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30006 33
zebrafish
(Danio rerio)
Actinopterygii mrps23 33 34
  • 58.13 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002893 33
  • 52.8 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpS23 33 34
  • 52.62 (n)
worm
(Caenorhabditis elegans)
Secernentea mrps-23 34
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 32 (a)
OneToOne
Species where no ortholog for MRPS23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS23 Gene

ENSEMBL:
Gene Tree for MRPS23 (if available)
TreeFam:
Gene Tree for MRPS23 (if available)

Paralogs for MRPS23 Gene

Pseudogenes.org Pseudogenes for MRPS23 Gene

genes like me logo Genes that share paralogs with MRPS23: view

No data available for Paralogs for MRPS23 Gene

Variants for MRPS23 Gene

Sequence variations from dbSNP and Humsavar for MRPS23 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000354932 -- 57,848,886(-) G/C intron_variant
rs1000599518 -- 57,843,299(-) C/T intron_variant
rs1000632510 -- 57,844,513(-) A/T intron_variant
rs1000788135 -- 57,850,168(-) G/A upstream_transcript_variant
rs1000904696 -- 57,850,368(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS23 Gene

Variant ID Type Subtype PubMed ID
esv3307805 CNV mobile element insertion 20981092
esv3387547 CNV insertion 20981092
nsv819589 CNV loss 19587683

Variation tolerance for MRPS23 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPS23 Gene

Human Gene Mutation Database (HGMD)
MRPS23
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS23 Gene

Disorders for MRPS23 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MRPS23 Gene - From: GeneCards

Disorder Aliases PubMed IDs
mitochondrial disorders
  • mitochondrial encephalomyopathies
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

RT23_HUMAN
  • Note=Defects in MRPS23 may play a role in mitochondrial disorders characterized by combined respiratory chain complex deficiencies. {ECO:0000269 PubMed:26741492}.

Additional Disease Information for MRPS23

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MRPS23: view

No data available for Genatlas for MRPS23 Gene

Publications for MRPS23 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present. (PMID: 11279123) Cavdar Koc E … Spremulli LL (The Journal of biological chemistry 2001) 2 3 58
  5. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N … Tanaka T (Genomics 2001) 3 4 58

Products for MRPS23 Gene

Sources for MRPS23 Gene

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