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Aliases for MRPS23 Gene

Aliases for MRPS23 Gene

  • Mitochondrial Ribosomal Protein S23 2 3
  • MRP-S23 3 4
  • S23mt 3 4
  • 28S Ribosomal Protein S23, Mitochondrial 3
  • CGI-138 3
  • HSPC329 3

External Ids for MRPS23 Gene

Previous GeneCards Identifiers for MRPS23 Gene

  • GC17M055658
  • GC17M058398
  • GC17M056255
  • GC17M056391
  • GC17M053271
  • GC17M055916
  • GC17M051277

Summaries for MRPS23 Gene

Entrez Gene Summary for MRPS23 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 7p. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS23 Gene

MRPS23 (Mitochondrial Ribosomal Protein S23) is a Protein Coding gene. GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS23 Gene

Genomics for MRPS23 Gene

Regulatory Elements for MRPS23 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPS23 Gene

57,834,781 bp from pter
57,850,072 bp from pter
15,292 bases
Minus strand

Genomic View for MRPS23 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS23 Gene

Proteins for MRPS23 Gene

  • Protein details for MRPS23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S23, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B2R6V3
    • Q96Q24
    • Q9BWH8
    • Q9P053

    Protein attributes for MRPS23 Gene

    190 amino acids
    Molecular mass:
    21771 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
    • Sequence=AAD34133.1; Type=Frameshift; Positions=138; Evidence={ECO:0000305}; Sequence=AAF29007.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for MRPS23 Gene

Proteomics data for MRPS23 Gene at MOPED

Post-translational modifications for MRPS23 Gene

  • Ubiquitination at Lys57 and Lys108
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS23 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MRPS23 Gene

Domains for MRPS23 Gene

Gene Families for MRPS23 Gene

  • MRPS :Mitochondrial ribosomal proteins / small subunits

Protein Domains for MRPS23 Gene

Suggested Antigen Peptide Sequences for MRPS23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPS23: view

No data available for UniProtKB/Swiss-Prot for MRPS23 Gene

Function for MRPS23 Gene

Gene Ontology (GO) - Molecular Function for MRPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPS23: view

Phenotypes for MRPS23 Gene

genes like me logo Genes that share phenotypes with MRPS23: view

Animal Model Products

miRNA for MRPS23 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPS23 Gene

Localization for MRPS23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS23 Gene


Subcellular locations from

Jensen Localization Image for MRPS23 Gene COMPARTMENTS Subcellular localization image for MRPS23 gene
Compartment Confidence
mitochondrion 5
cytoskeleton 4
nucleus 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MRPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
GO:0031965 nuclear membrane IDA --
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with MRPS23: view

Pathways for MRPS23 Gene

SuperPathways for MRPS23 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPS23: view

No data available for Pathways by source for MRPS23 Gene

Transcripts for MRPS23 Gene

mRNA/cDNA for MRPS23 Gene

Unigene Clusters for MRPS23 Gene

Mitochondrial ribosomal protein S23:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS23

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS23 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP3: -

Relevant External Links for MRPS23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS23 Gene

mRNA expression in normal human tissues for MRPS23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MRPS23 Gene

This gene is overexpressed in Tlymphocyte (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS23 Gene

SOURCE GeneReport for Unigene cluster for MRPS23 Gene Hs.5836

genes like me logo Genes that share expressions with MRPS23: view

Expression partners for MRPS23 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS23 Gene

Orthologs for MRPS23 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS23 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS23 35
  • 86.32 (n)
  • 82.11 (a)
MRPS23 36
  • 82 (a)
(Canis familiaris)
Mammalia MRPS23 35
  • 86.14 (n)
  • 82.63 (a)
MRPS23 36
  • 83 (a)
(Mus musculus)
Mammalia Mrps23 35
  • 82.8 (n)
  • 82.17 (a)
Mrps23 16
Mrps23 36
  • 74 (a)
(Pan troglodytes)
Mammalia MRPS23 35
  • 99.65 (n)
  • 99.47 (a)
MRPS23 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mrps23 35
  • 79.1 (n)
  • 73.45 (a)
(Monodelphis domestica)
Mammalia MRPS23 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS23 36
  • 64 (a)
(Gallus gallus)
Aves MRPS23 35
  • 58.19 (n)
  • 54.8 (a)
MRPS23 36
  • 51 (a)
(Anolis carolinensis)
Reptilia MRPS23 36
  • 51 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps23 35
  • 56.08 (n)
  • 57.06 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30006 35
(Danio rerio)
Actinopterygii mrps23 35
  • 58.13 (n)
  • 53.57 (a)
mrps23 36
  • 44 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002893 35
  • 52.8 (n)
  • 45.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS23 35
  • 52.62 (n)
  • 44.63 (a)
mRpS23 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea mrps-23 36
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
Species with no ortholog for MRPS23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS23 Gene

Gene Tree for MRPS23 (if available)
Gene Tree for MRPS23 (if available)

Paralogs for MRPS23 Gene Pseudogenes for MRPS23 Gene

genes like me logo Genes that share paralogs with MRPS23: view

No data available for Paralogs for MRPS23 Gene

Variants for MRPS23 Gene

Sequence variations from dbSNP and Humsavar for MRPS23 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2099914 -- 57,839,992(+) TAATT(C/G)GCTAA intron-variant
rs2586037 -- 57,838,804(+) TGAGA(C/G)CATAC downstream-variant-500B
rs2586038 -- 57,839,280(+) AAAGC(G/T)CAAGT utr-variant-3-prime
rs2586039 -- 57,842,221(+) gttgc(C/T)caggc intron-variant
rs2586040 -- 57,842,889(+) atata(C/T)ataca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS23 Gene

Variant ID Type Subtype PubMed ID
nsv819589 CNV Loss 19587683
esv272079 CNV Insertion 20981092

Relevant External Links for MRPS23 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS23 Gene

Disorders for MRPS23 Gene

Relevant External Links for MRPS23

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MRPS23 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MRPS23 Gene

Publications for MRPS23 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4
  4. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. (PMID: 10938081) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2000) 3 4
  5. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3

Products for MRPS23 Gene

Sources for MRPS23 Gene

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