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Aliases for MRPS23 Gene

Aliases for MRPS23 Gene

  • Mitochondrial Ribosomal Protein S23 2 3 5
  • MRP-S23 3 4
  • S23mt 3 4
  • CGI-138 3
  • HSPC329 3

External Ids for MRPS23 Gene

Previous GeneCards Identifiers for MRPS23 Gene

  • GC17M055658
  • GC17M058398
  • GC17M056255
  • GC17M056391
  • GC17M053271
  • GC17M055916
  • GC17M051277

Summaries for MRPS23 Gene

Entrez Gene Summary for MRPS23 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 7p. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS23 Gene

MRPS23 (Mitochondrial Ribosomal Protein S23) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS23 Gene

Genomics for MRPS23 Gene

Regulatory Elements for MRPS23 Gene

Promoters for MRPS23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPS23 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPS23 Gene

Chromosome:
17
Start:
57,834,781 bp from pter
End:
57,850,072 bp from pter
Size:
15,292 bases
Orientation:
Minus strand

Genomic View for MRPS23 Gene

Genes around MRPS23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS23 Gene

Proteins for MRPS23 Gene

  • Protein details for MRPS23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3D9-RT23_HUMAN
    Recommended name:
    28S ribosomal protein S23, mitochondrial
    Protein Accession:
    Q9Y3D9
    Secondary Accessions:
    • B2R6V3
    • Q96Q24
    • Q9BWH8
    • Q9P053

    Protein attributes for MRPS23 Gene

    Size:
    190 amino acids
    Molecular mass:
    21771 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
    SequenceCaution:
    • Sequence=AAD34133.1; Type=Frameshift; Positions=138; Evidence={ECO:0000305}; Sequence=AAF29007.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS23 Gene

neXtProt entry for MRPS23 Gene

Proteomics data for MRPS23 Gene at MOPED

Post-translational modifications for MRPS23 Gene

  • Ubiquitination at Lys 57
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS23 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MRPS23 Gene

Domains & Families for MRPS23 Gene

Gene Families for MRPS23 Gene

Protein Domains for MRPS23 Gene

Suggested Antigen Peptide Sequences for MRPS23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPS23: view

No data available for UniProtKB/Swiss-Prot for MRPS23 Gene

Function for MRPS23 Gene

Phenotypes for MRPS23 Gene

GenomeRNAi human phenotypes for MRPS23:
genes like me logo Genes that share phenotypes with MRPS23: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS23 Gene

Localization for MRPS23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS23 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS23 Gene COMPARTMENTS Subcellular localization image for MRPS23 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MRPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with MRPS23: view

Pathways & Interactions for MRPS23 Gene

genes like me logo Genes that share pathways with MRPS23: view

Gene Ontology (GO) - Biological Process for MRPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
genes like me logo Genes that share ontologies with MRPS23: view

No data available for SIGNOR curated interactions for MRPS23 Gene

Drugs & Compounds for MRPS23 Gene

No Compound Related Data Available

Transcripts for MRPS23 Gene

mRNA/cDNA for MRPS23 Gene

Unigene Clusters for MRPS23 Gene

Mitochondrial ribosomal protein S23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS23 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2:
SP3: -

Relevant External Links for MRPS23 Gene

GeneLoc Exon Structure for
MRPS23
ECgene alternative splicing isoforms for
MRPS23

Expression for MRPS23 Gene

mRNA expression in normal human tissues for MRPS23 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS23 Gene

This gene is overexpressed in Tlymphocyte (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS23 Gene



SOURCE GeneReport for Unigene cluster for MRPS23 Gene Hs.5836

genes like me logo Genes that share expression patterns with MRPS23: view

Protein tissue co-expression partners for MRPS23 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS23 Gene

Orthologs for MRPS23 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS23 36
  • 99 (a)
OneToOne
MRPS23 35
  • 99.65 (n)
  • 99.47 (a)
cow
(Bos Taurus)
Mammalia MRPS23 35
  • 86.32 (n)
  • 82.11 (a)
MRPS23 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS23 36
  • 83 (a)
OneToOne
MRPS23 35
  • 86.14 (n)
  • 82.63 (a)
mouse
(Mus musculus)
Mammalia Mrps23 36
  • 74 (a)
OneToOne
Mrps23 16
Mrps23 35
  • 82.8 (n)
  • 82.17 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPS23 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS23 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps23 35
  • 79.1 (n)
  • 73.45 (a)
chicken
(Gallus gallus)
Aves MRPS23 35
  • 58.19 (n)
  • 54.8 (a)
MRPS23 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPS23 36
  • 51 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.30006 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps23 35
  • 56.08 (n)
  • 57.06 (a)
zebrafish
(Danio rerio)
Actinopterygii mrps23 36
  • 44 (a)
OneToOne
mrps23 35
  • 58.13 (n)
  • 53.57 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002893 35
  • 52.8 (n)
  • 45.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS23 36
  • 30 (a)
OneToOne
mRpS23 35
  • 52.62 (n)
  • 44.63 (a)
worm
(Caenorhabditis elegans)
Secernentea mrps-23 36
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
OneToOne
Species with no ortholog for MRPS23:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS23 Gene

ENSEMBL:
Gene Tree for MRPS23 (if available)
TreeFam:
Gene Tree for MRPS23 (if available)

Paralogs for MRPS23 Gene

Pseudogenes.org Pseudogenes for MRPS23 Gene

genes like me logo Genes that share paralogs with MRPS23: view

No data available for Paralogs for MRPS23 Gene

Variants for MRPS23 Gene

Sequence variations from dbSNP and Humsavar for MRPS23 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2685487 -- 57,839,018(-) TGCCT(C/T)CCTGG utr-variant-3-prime
rs2685490 -- 57,845,302(+) AAAAT(A/T)TCCAA intron-variant
rs2685492 -- 57,845,728(+) AGTCC(A/C/G)AGTCC intron-variant
rs2099914 -- 57,839,992(+) TAATT(C/G)GCTAA intron-variant
rs3177058 -- 57,850,008(-) ATCAT(A/G/T)GCAGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MRPS23 Gene

Variant ID Type Subtype PubMed ID
nsv819589 CNV Loss 19587683
esv272079 CNV Insertion 20981092

Variation tolerance for MRPS23 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.18; 23.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS23 Gene

HapMap Linkage Disequilibrium report
MRPS23

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS23 Gene

Disorders for MRPS23 Gene

Relevant External Links for MRPS23

Genetic Association Database (GAD)
MRPS23
Human Genome Epidemiology (HuGE) Navigator
MRPS23
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS23

No disorders were found for MRPS23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS23 Gene

Publications for MRPS23 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3
  3. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for MRPS23 Gene

Sources for MRPS23 Gene

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