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MRPS22 Gene

protein-coding   GIFtS: 53
GCID: GC03P138725

Mitochondrial Ribosomal Protein S22

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Ribosomal Protein S221 2     S22mt2 3
C3orf52 3 5     COXPD52 5
MRP-S222 3     28S Ribosomal Protein S22, Mitochondrial2
RPMS222 3     GIBT2

External Ids:    HGNC: 145081   Entrez Gene: 569452   Ensembl: ENSG000001751107   OMIM: 6058105   UniProtKB: P826503   

Export aliases for MRPS22 gene to outside databases

Previous GC identifers: GC03P136006 GC03P139951 GC03P140383 GC03P140545 GC03P136438


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRPS22 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes.
This gene lies telomeric of and is transcribed in the opposite direction from the forkhead box L2 gene. A
pseudogene corresponding to this gene is found on chromosome Xq. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPS22 Gene:
MRPS22 (mitochondrial ribosomal protein S22) is a protein-coding gene. Diseases associated with MRPS22 include combined oxidative phosphorylation deficiency 5, and blepharophimosis, ptosis, and epicanthus inversus syndrome. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS22 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MRPS22 gene promoter:
         NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPS22 promoter sequence
   Search Chromatin IP Primers for MRPS22

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRPS22


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23   Ensembl cytogenetic band:  3q23   HGNC cytogenetic band: 3q23

MRPS22 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPS22 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P138725:  view genomic region     (about GC identifiers)

Start:
138,724,648 bp from pter      End:
139,076,065 bp from pter
Size:
351,418 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RT22_HUMAN, P82650 (See protein sequence)
Recommended Name: 28S ribosomal protein S22, mitochondrial  
Size: 360 amino acids; 41280 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30
distinct proteins

Explore the universe of human proteins at neXtProt for MRPS22: NX_P82650

Explore proteomics data for MRPS22 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys104, Lys199, Lys329
  • Modification sites at PhosphoSitePlus

  • See MRPS22 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_064576.1  
    ENSEMBL proteins: 
     ENSP00000418008   ENSP00000417104   ENSP00000420482   ENSP00000418233   ENSP00000419920  
     ENSP00000419737   ENSP00000419303   ENSP00000420229   ENSP00000310785  

    MRPS22 Human Recombinant Protein Products:

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    Novus Biologicals MRPS22 Lysate
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    MRPS22 Assay Products:

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    Cloud-Clone Corp. ELISAs for MRPS22
    Cloud-Clone Corp. CLIAs for MRPS22


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MRPS: Mitochondrial ribosomal proteins / small subunits

    1 InterPro protein domain:
     IPR019374 Ribosomal_S22_mit

    Graphical View of Domain Structure for InterPro Entry P82650

    ProtoNet protein and cluster: P82650


    MRPS22 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IDA10938081
         
    MRPS22 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for MRPS22:
     Decreased viability with pacli  G0/1 arrest  Increased G1 DNA content 

    Animal Models:
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MRPS22

    miRNA
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    miRTarBase miRNAs that target MRPS22:
    hsa-mir-24-3p (MIRT030608)

    Block miRNA regulation of human, mouse, rat MRPS22 using miScript Target Protectors
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Predesigned siRNA for gene silencing in human, mouse, rat MRPS22

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    GenScript: all cDNA clones in your preferred vector: MRPS22 (NM_020191)
    Sino Biological Human cDNA Clone for MRPS22
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS22

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS22


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RT22_HUMAN, P82650: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    chloroplast1
    cytosol1
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005761mitochondrial ribosome NAS10938081
    GO:0005763mitochondrial small ribosomal subunit IDA10938081
    GO:0005840ribosome ----

    MRPS22 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRPS22
    Interactions:

        Search GeneGlobe Interaction Network for MRPS22

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for MRPS22 (P826502, 3 ENSP000003107854) via UniProtKB, MINT, STRING, and/or I2D (see all 381)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKBIL1Q9UBC13, ENSP000003653184I2D: score=2 STRING: ENSP00000365318
    ENSG00000206440Q9UBC13, ENSP000003831424I2D: score=2 STRING: ENSP00000383142
    ENSG00000227565Q9UBC13I2D: score=2 
    ENSG00000234530Q9UBC13I2D: score=2 
    ENSG00000235125Q9UBC13I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    MRPS22 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRPS22 (RT22)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MRPS22 gene: 
    NM_020191.2  

    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000495075(uc003etb.3) ENST00000495225 ENST00000489521 ENST00000498505(uc003etc.3)
    ENST00000465056 ENST00000480938 ENST00000465373 ENST00000466690 ENST00000486705
    ENST00000478464 ENST00000483545 ENST00000480644 ENST00000492644 ENST00000310776

    miRNA
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    Block miRNA regulation of human, mouse, rat MRPS22 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate MRPS22
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for MRPS22
    Predesigned siRNA for gene silencing in human, mouse, rat MRPS22
    Clone
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    OriGene clones in human, mouse for MRPS22 (see all 7)
    OriGene ORF clones in mouse, rat for MRPS22
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MRPS22 (NM_020191)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRPS22
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS22
    Primer
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    OriGene qPCR primer pairs and template standards for MRPS22
    OriGene qSTAR qPCR primer pairs in human, mouse for MRPS22
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRPS22
      QuantiTect SYBR Green Assays in human, mouse, rat MRPS22
      QuantiFast Probe-based Assays in human, mouse, rat MRPS22

    Selected AceView cDNA sequences (see all 297):

    BX109148 BM826099 CR596872 AW673008 BM681611 BM751452 BM854264 BM474713 
    BQ014088 CR610332 AA758192 BU508732 BM741708 BG256860 AV733779 CB110562 
    BE466254 AW675177 NM_020191 AI004657 CD673045 BM842024 BG109979 BM829758 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MRPS22 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10a · 10b · 10c
    SP1:                    -     -     -                                                     -     -     -                                             
    SP2:                    -     -     -                             -                       -     -     -                                             
    SP3:                    -     -     -                       -     -     -                 -     -     -                                             
    SP4:                                -                             -                       -     -     -                                             
    SP5:                    -     -     -                             -                       -     -     -                                             


    ECgene alternative splicing isoforms for MRPS22

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRPS22 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    MRPS22 Expression
    About this image


    MRPS22 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    MRPS22 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRPS22 Protein Expression
        Custom PCR Arrays for MRPS22
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS22

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MRPS22 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrps221 , 5 mitochondrial ribosomal protein S221, 5 83.57(n)1
    79.11(a)1
      9 (51.41 cM)5
    646551  NM_025485.31  NP_079761.11 
     985887335 
    chicken
    (Gallus gallus)
    Aves MRPS221 mitochondrial ribosomal protein S22 63.48(n)
    60.39(a)
      424824  XM_422638.4  XP_422638.3 
    lizard
    (Anolis carolinensis)
    Reptilia MRPS226
    mitochondrial ribosomal protein S22
    62(a)
    1 ↔ 1
    3(27525279-27535306)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.183372 Xenopus laevis transcribed sequence with weak similarity more 72.74(n)    CD301940.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.296882 Transcribed sequence with weak similarity to protein more 69.9(n)    CK353891.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpS221 , 3 protein biosynthesis structural
    constituent of more3
    mitochondrial ribosomal protein S221
    34(a)3
    46.14(n)1
    34.71(a)1
      98B63
    433451  NM_079813.21  NP_524537.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C14A4.143
    mrps-221
    mrps-221 33(a)3
    46.93(n)1
    34.66(a)1
      II(10582539-10583985)3
    1746321  NM_063880.41  NP_496281.11 


    ENSEMBL Gene Tree for MRPS22 (if available)
    TreeFam Gene Tree for MRPS22 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MRPS22 gene

    MRPS22 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MRPS22
    PGOHUM00000241431


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MRPS22 (see all 360)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0427334
    Combined oxidative phosphorylation deficiency 5 (COXPD5)4--see VAR_0427332 R H mis40--------
    rs1194780591,2
    Cpathogenic1139048356(+) GGAGCG/ATTTTA 2 /H /R mis11Minor allele frequency- A:0.00NA 4538
    rs1470287861,2
    Cuntested1139055118(+) CAGAAA/C/GGGAGC 2 K syn10--------
    rs1509774451,2
    --139040333(+) ACATGA/GTCTTT 1 -- us2k10--------
    rs1825926511,2
    --139040365(+) ATTTTA/TAAATG 1 -- us2k10--------
    rs1179929511,2
    F--139040408(+) GATTAT/CGCAAT 1 -- us2k11Minor allele frequency- C:0.02EA 120
    rs1493078761,2
    C--139040454(+) TTGGC-/AACAAA 1 -- us2k10--------
    rs68058191,2
    C,H--139040455(+) ttggcA/Gcaaat 1 -- us2k14Minor allele frequency- G:0.00NS EA 420
    rs1408001521,2
    C--139040581(+) AGAGAC/TAGACT 1 -- us2k10--------
    rs776513851,2
    C,F--139040648(+) CATGCG/AGAATT 1 -- us2k11Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for MRPS22 (138724648 - 138974648 bp, first 250kb of MRPS22)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MRPS22:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv4035CNV Insertion18451855
    nsv4034CNV Loss18451855
    nsv877543CNV Gain21882294

    Human Gene Mutation Database (HGMD): MRPS22
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRPS22
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPS22

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605810   
    OMIM disorders: 611719  
    UniProtKB/Swiss-Prot: RT22_HUMAN, P82650
  • Combined oxidative phosphorylation deficiency 5 (COXPD5) [MIM:611719]: A mitochondrial disease resulting
    in severe metabolic acidosis, edema, hypertrophic cardiomyopathy, tubulopathy, and hypotonia. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • 16 diseases for MRPS22:    
    About MalaCards
    combined oxidative phosphorylation deficiency 5    blepharophimosis, ptosis, and epicanthus inversus syndrome    blepharophimosis    cornelia de lange syndrome
    hypotonia    brain cancer    tonsillitis    obesity
    multiple myeloma    myeloma    malaria    thyroiditis
    cerebritis    breast cancer    endotheliitis    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for MRPS22:
    Blepharophimosis     Cornelia de Lange syndrome

    MRPS22 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRPS22
    Human Genome Epidemiology (HuGE) Navigator: MRPS22 (1 document)

    Export disorders for MRPS22 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRPS22 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with MRPS22)
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    1. The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome. (PubMed id 11175783)1, 2, 3 Crisponi L....Pilia G. (Nat. Genet. 2001)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Antenatal mitochondrial disease caused by mitochondrial ribosomal protein (MRPS22) mutation. (PubMed id 17873122)1, 2 Saada A.... Elpeleg O. (J. Med. Genet. 2007)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. (PubMed id 10938081)1, 2 Koc E.C....Spremulli L.L. (J. Biol. Chem. 2000)
    6. The effect of mutated mitochondrial ribosomal proteins S16 and S22 on the assembly of the small and large ribosomal subunits in human mitochondria. (PubMed id 18539099)1, 9 Emdadul Haque M....Saada A. (Mitochondrion 2008)
    7. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    8. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. (PubMed id 23184937)1 Xie Y....Cong F. (J. Biol. Chem. 2013)
    9. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    10. Profiling of Parkin-binding partners using tandem affinity purification. (PubMed id 24244333)1 Zanon A....Pichler I. (PLoS ONE 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 56945 HGNC: 14508 AceView: MRPS22 Ensembl:ENSG00000175110 euGenes: HUgn56945
    ECgene: MRPS22 H-InvDB: MRPS22

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRPS22 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MRPS22 gene:
    Search GeneIP for patents involving MRPS22

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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