MRPS21 Gene
protein-coding GIFtS: 45
GCID: GC01P150266
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|
mitochondrial ribosomal protein S21
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Aliases
for MRPS21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein S211 2 | | MRP-S212 3 | | RPMS212 3 | | S21mt2 3 | | 28S Ribosomal Protein S21, Mitochondrial2 | | Mitochondrial 28S Ribosomal Protein S212 |
Export aliases for MRPS21 gene to outside databasesPrevious GC identifers: GC01P147917 GC01P146008 GC01P147041 GC01P147482 GC01P147079 GC01P148532 GC01P121644 |
Summaries
for MRPS21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPS21:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit proteinthat belongs to the ribosomal protein S21P family. Pseudogenes corresponding to this gene are found on chromosomes 1p,1q, 9p, 10p, 10q, 16q, and 17q. Available sequence data analyses identified splice variants that differ in the 5' UTR;both transcripts encode the same protein. (provided by RefSeq, Jul 2008)
Gene Wiki entry for MRPS21
|
Genomic Views
for MRPS21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPS21 gene promoter:
FOXF2 Bach2 p300 Lmo2 MyoD LUN-1 Arnt GATA-1 YY1 Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPS21
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS21 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q21.2 HGNC cytogenetic band: 1q21MRPS21 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P150266: view genomic region
(about GC identifiers)
Start:
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150,266,269 bp from pter |
End:
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150,281,414 bp from pter |
Size:
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15,146 bases |
Orientation:
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plus strand |
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Proteins
for MRPS21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RT21_HUMAN, P82921 (See
protein sequence)Recommended Name: 28S ribosomal protein S21, mitochondrial Size: 87 amino acids; 10742 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinctproteins
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAG14953.1; Type=Erroneous initiation;
Secondary accessions: Q5TB11 Q9BST6Explore the universe of human proteins at neXtProt for MRPS21: NX_P82921
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P82921
MRPS21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_061870.1 NP_114107.1
ENSEMBL proteins: ENSP00000312395 ENSP00000358080
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005763 | mitochondrial small ribosomal subunit |
IDA | 11279123 |
MRPS21 for ontologies About GeneDecksing
MRPS21 Antibody Products:
Assay Products for MRPS21: |
Protein
Domains /
Families
for MRPS21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPS21 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P82921ProtoNet protein and cluster: P82921 UniProtKB/Swiss-Prot: RT21_HUMAN, P82921Similarity: Belongs to the ribosomal protein S21P family |
Function
for MRPS21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS21 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS21 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MRPS21 (NM_018997) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS21 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS21 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS21 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
NAS | 11279123 |
MRPS21 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MRPS21:
|
Pathways & Interactions
for MRPS21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS21
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/235 Interacting proteins for MRPS21 (P829212, 3 ENSP000003123954) via UniProtKB, MINT, STRING, and/or I2D (see all 235)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
MRPS21 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRPS21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPS21
Search CenterWatch for drugs/clinical trials and news about MRPS21 / RT21
|
Transcripts
for MRPS21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPS21 gene (2 alternative transcripts): NM_018997.2 NM_031901.4 Unigene Cluster for MRPS21: Mitochondrial ribosomal protein S21 Hs.405880 [show with all ESTs]Unigene Representative Sequence: CA4553442 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000309092(uc001euk.3) ENST00000369084(uc001eul.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS21 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS21 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): MRPS21 (NM_018997) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS21 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS21 |
Additional cDNA sequence: AB049955.1 AF182417.1 AK058101.1 AK289467.1 BC004566.2 BC006554.2 10 DOTS entries: DT.100790569 DT.452111 DT.92451864 DT.100790568 DT.40306234 DT.86999872 DT.92451870 DT.95201664 DT.92451869 DT.121421244 24/383 AceView cDNA sequences (see all 383): AI915738 BC004566 BM698258 W32638 BC006554 AI224890 AA505477 CD512787 CR610321 NM_031901 BE394288 BQ084134 AA527577 CB108185 BU784752 F13393 CA412381 AI186127 AI276272 H87905 BG338443 C05083 AI186402 BU689268
GeneLoc Exon Structure
|
Expression
for MRPS21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPS21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGCAAAAA
About this image
See MRPS21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPS21
SOURCE GeneReport for Unigene cluster: Hs.405880
SABiosciences Custom PCR Arrays for MRPS21
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS21
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPS21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS21 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS21 |
Orthologs
for MRPS21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MRPS21 gene from 7/18 species (see all 18) About this table
ENSEMBL Gene Tree for MRPS21 (if available)
TreeFam Gene Tree for MRPS21 (if available) |
Paralogs
for MRPS21 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRPS21 gene
MRPS21 for paralogs About GeneDecksing
5/7 Pseudogenes.org Pseudogenes for MRPS21 (see all 7)
PGOHUM00000238964 PGOHUM00000249126 PGOHUM00000249127 PGOHUM00000237105 PGOHUM00000244058
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Genomic Variants
for MRPS21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPS21 (150266269 - 150281414 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MRPS21: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS21 |
|
Disorders
/ Diseases
for MRPS21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRPS21 for disorders About MalaCards
MRPS21 for disorders About GeneDecksing
OMIM gene information: 611984
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MRPS21 (1 document)
Export disorders for MRPS21 gene to outside databases
|
Publications
for MRPS21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPS21 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with MRPS21) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041)1, 2 Suzuki T....Watanabe K. (2001)
- The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2 Koc E.C.... Spremulli L.L. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
|
External Searches for MRPS21 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPS21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPS21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPS21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPS21 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MRPS21 gene:
Search GeneIP for patents involving MRPS21
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPS21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRPS21 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPS21 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS21 | | | OriGene Protein Over-expression Lysate for MRPS21 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRPS21 | | OriGene 3'-UTR Clone for MRPS21 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS21 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS21 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | MRPS21 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS21 |
|  |  |  | | | | Search ThermoFisher Antibodies for MRPS21 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS21 |
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