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Aliases for MRPS21 Gene

Aliases for MRPS21 Gene

  • Mitochondrial Ribosomal Protein S21 2 3
  • MRP-S21 3 4
  • RPMS21 3 4
  • S21mt 3 4
  • 28S Ribosomal Protein S21, Mitochondrial 3
  • Mitochondrial 28S Ribosomal Protein S21 3
  • MDS016 3

External Ids for MRPS21 Gene

Previous GeneCards Identifiers for MRPS21 Gene

  • GC01P147917
  • GC01P146008
  • GC01P147041
  • GC01P147482
  • GC01P147079
  • GC01P148532
  • GC01P150266
  • GC01P121644

Summaries for MRPS21 Gene

Entrez Gene Summary for MRPS21 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S21P family. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 9p, 10p, 10q, 16q, and 17q. Available sequence data analyses identified splice variants that differ in the 5' UTR; both transcripts encode the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS21 Gene

MRPS21 (Mitochondrial Ribosomal Protein S21) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS21 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS21 Gene

Genomics for MRPS21 Gene

Regulatory Elements for MRPS21 Gene

Genomic Location for MRPS21 Gene

150,293,720 bp from pter
150,308,979 bp from pter
15,260 bases
Plus strand

Genomic View for MRPS21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS21 Gene

Proteins for MRPS21 Gene

  • Protein details for MRPS21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S21, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q5TB11
    • Q9BST6

    Protein attributes for MRPS21 Gene

    87 amino acids
    Molecular mass:
    10742 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins
    • Sequence=AAG14953.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MRPS21 Gene

Proteomics data for MRPS21 Gene at MOPED

Post-translational modifications for MRPS21 Gene

  • Ubiquitination at Lys40
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS21 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MRPS21 Gene

Domains for MRPS21 Gene

Gene Families for MRPS21 Gene

Protein Domains for MRPS21 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S21P family.
  • Belongs to the ribosomal protein S21P family.
genes like me logo Genes that share domains with MRPS21: view

Function for MRPS21 Gene

Gene Ontology (GO) - Molecular Function for MRPS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MRPS21: view

Phenotypes for MRPS21 Gene

GenomeRNAi human phenotypes for MRPS21:
genes like me logo Genes that share phenotypes with MRPS21: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS21

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRPS21 Gene

Localization for MRPS21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS21 Gene


Subcellular locations from

Jensen Localization Image for MRPS21 Gene COMPARTMENTS Subcellular localization image for MRPS21 gene
Compartment Confidence
mitochondrion 5
extracellular 3
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for MRPS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IDA 11279123
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with MRPS21: view

Pathways for MRPS21 Gene

SuperPathways for MRPS21 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
genes like me logo Genes that share pathways with MRPS21: view

Pathways by source for MRPS21 Gene

1 KEGG pathway for MRPS21 Gene

Interacting Proteins for MRPS21 Gene

Gene Ontology (GO) - Biological Process for MRPS21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPS21: view

Transcripts for MRPS21 Gene

mRNA/cDNA for MRPS21 Gene

Unigene Clusters for MRPS21 Gene

Mitochondrial ribosomal protein S21:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS21

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS21 Gene

No ASD Table

Relevant External Links for MRPS21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS21 Gene

mRNA expression in normal human tissues for MRPS21 Gene

Protein differential expression in normal tissues for MRPS21 Gene

This gene is overexpressed in Lung (24.9) and Breast (20.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MRPS21 Gene

SOURCE GeneReport for Unigene cluster for MRPS21 Gene Hs.405880

genes like me logo Genes that share expressions with MRPS21: view

Expression partners for MRPS21 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS21 Gene

Orthologs for MRPS21 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS21 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS21 35
  • 93.87 (n)
  • 96.55 (a)
(Canis familiaris)
Mammalia MRPS21 35
  • 91.19 (n)
  • 94.25 (a)
(Mus musculus)
Mammalia Mrps21 35
  • 85.06 (n)
  • 90.8 (a)
Mrps21 16
(Pan troglodytes)
Mammalia MRPS21 35
  • 100 (n)
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrps21 35
  • 86.59 (n)
  • 91.95 (a)
(Gallus gallus)
Aves MRPS21 35
  • 67.43 (n)
  • 70.11 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps21 35
  • 67.82 (n)
  • 70.11 (a)
(Danio rerio)
Actinopterygii mrps21 35
  • 61.3 (n)
  • 60.92 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009152 35
  • 57.25 (n)
  • 54.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS21 35
  • 53.33 (n)
  • 50.59 (a)
Species with no ortholog for MRPS21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS21 Gene

Gene Tree for MRPS21 (if available)
Gene Tree for MRPS21 (if available)

Paralogs for MRPS21 Gene

No data available for Paralogs for MRPS21 Gene

Variants for MRPS21 Gene

Sequence variations from dbSNP and Humsavar for MRPS21 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3036 -- 150,308,909(-) agttc(A/C)agtgg utr-variant-3-prime
rs3037 -- 150,308,908(-) gttca(A/G)gtggc utr-variant-3-prime
rs4845 - 150,308,116(+) CCGCC(A/G)GCGAC missense, reference
rs8006 -- 150,308,367(+) TGTTT(C/G)TATAT utr-variant-3-prime
rs9913 -- 150,308,288(+) CTTTT(C/T)TTTGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPS21 Gene

Variant ID Type Subtype PubMed ID
nsv831548 CNV Loss 17160897

Relevant External Links for MRPS21 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS21 Gene

Disorders for MRPS21 Gene

Relevant External Links for MRPS21

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MRPS21 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MRPS21 Gene

Publications for MRPS21 Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 3 4
  2. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PMID: 11402041) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for MRPS21 Gene

Sources for MRPS21 Gene

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