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MRPS21 Gene

protein-coding   GIFtS: 51
GCID: GC01P150266

Mitochondrial Ribosomal Protein S21

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Ribosomal Protein S211 2
MRP-S212 3
RPMS212 3
S21mt2 3
28S Ribosomal Protein S21, Mitochondrial2
Mitochondrial 28S Ribosomal Protein S212

External Ids:    HGNC: 140461   Entrez Gene: 544602   Ensembl: ENSG000001871457   OMIM: 6119845   UniProtKB: P829213   

Export aliases for MRPS21 gene to outside databases

Previous GC identifers: GC01P147917 GC01P146008 GC01P147041 GC01P147482 GC01P147079 GC01P148532 GC01P121644


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRPS21 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
28S subunit protein that belongs to the ribosomal protein S21P family. Pseudogenes corresponding to this gene are
found on chromosomes 1p, 1q, 9p, 10p, 10q, 16q, and 17q. Available sequence data analyses identified splice
variants that differ in the 5' UTR; both transcripts encode the same protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPS21 Gene:
MRPS21 (mitochondrial ribosomal protein S21) is a protein-coding gene. Diseases associated with MRPS21 include malaria. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS21 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRPS21 gene promoter:
         FOXF2   Bach2   p300   Lmo2   MyoD   LUN-1   Arnt   GATA-1   YY1   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPS21 promoter sequence
   Search Chromatin IP Primers for MRPS21

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRPS21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.2   HGNC cytogenetic band: 1q21

MRPS21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPS21 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P150266:  view genomic region     (about GC identifiers)

Start:
150,266,269 bp from pter      End:
150,281,414 bp from pter
Size:
15,146 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RT21_HUMAN, P82921 (See protein sequence)
Recommended Name: 28S ribosomal protein S21, mitochondrial  
Size: 87 amino acids; 10742 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30
distinct proteins
Sequence caution: Sequence=AAG14953.1; Type=Erroneous initiation;
Secondary accessions: Q5TB11 Q9BST6

Explore the universe of human proteins at neXtProt for MRPS21: NX_P82921

Explore proteomics data for MRPS21 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys40
  • Modification sites at PhosphoSitePlus

  • See MRPS21 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_061870.1  NP_114107.1  

    ENSEMBL proteins: 
     ENSP00000312395   ENSP00000358080  

    MRPS21 Human Recombinant Protein Products:

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    Novus Biologicals MRPS21 Protein
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    Cloud-Clone Corp. Proteins for MRPS21

    MRPS21 Antibody Products:

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    Search for Antibodies for MRPS21 at Abcam
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    LSBio Antibodies in human, mouse, rat for MRPS21

    MRPS21 Assay Products:

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    Cloud-Clone Corp. ELISAs for MRPS21
    Cloud-Clone Corp. CLIAs for MRPS21


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MRPS: Mitochondrial ribosomal proteins / small subunits

    1 InterPro protein domain:
     IPR001911 Ribosomal_S21

    Graphical View of Domain Structure for InterPro Entry P82921

    ProtoNet protein and cluster: P82921

    UniProtKB/Swiss-Prot: RT21_HUMAN, P82921
    Similarity: Belongs to the ribosomal protein S21P family


    MRPS21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS11279123
    GO:0044822poly(A) RNA binding IDA--
         
    MRPS21 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MRPS21:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRPS21
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MRPS21

    miRNA
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    Block miRNA regulation of human, mouse, rat MRPS21 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MRPS21:
    hsa-miR-1248
    SwitchGear 3'UTR luciferase reporter plasmidMRPS21 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MRPS21
    Predesigned siRNA for gene silencing in human, mouse, rat MRPS21

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for MRPS21

    Clone
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    OriGene ORF clones in mouse, rat for MRPS21
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    GenScript: all cDNA clones in your preferred vector (see all 2): MRPS21 (NM_018997)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRPS21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS21

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS21


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RT21_HUMAN, P82921: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    extracellular3
    cytosol2
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005763mitochondrial small ribosomal subunit IDA11279123
    GO:0005840ribosome ----

    MRPS21 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MRPS21 About    
    See pathways by source

    SuperPathContained pathways About
    1CFTR translational fidelity class I mutations
    Ribosome0.54

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for MRPS21):
        Ribosome


    MRPS21 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRPS21
    Interactions:

        Search GeneGlobe Interaction Network for MRPS21

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for MRPS21 (P829212, 3 ENSP000003123954) via UniProtKB, MINT, STRING, and/or I2D (see all 249)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    USP42Q9H9J43, ENSP000003019624I2D: score=2 STRING: ENSP00000301962
    USP44Q9H0E73, ENSP000002584994I2D: score=2 STRING: ENSP00000258499
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation NAS11279123

    MRPS21 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRPS21 (RT21)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for MRPS21 gene (2 alternative transcripts): 
    NM_018997.3  NM_031901.5  

    Unigene Cluster for MRPS21:

    Mitochondrial ribosomal protein S21
    Hs.405880  [show with all ESTs]
    Unigene Representative Sequence: CA455344
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309092(uc001euk.3) ENST00000369084(uc001eul.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MRPS21 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MRPS21:
    hsa-miR-1248
    SwitchGear 3'UTR luciferase reporter plasmidMRPS21 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MRPS21
    Predesigned siRNA for gene silencing in human, mouse, rat MRPS21
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    GenScript: all cDNA clones in your preferred vector (see all 2): MRPS21 (NM_018997)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRPS21
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS21
    Primer
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    OriGene qPCR primer pairs and template standards for MRPS21
    OriGene qSTAR qPCR primer pairs in human, mouse for MRPS21
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRPS21
      QuantiTect SYBR Green Assays in human, mouse, rat MRPS21
      QuantiFast Probe-based Assays in human, mouse, rat MRPS21

    Additional mRNA sequence: 

    AB049955.1 AF182417.1 AK058101.1 AK289467.1 BC004566.2 BC006554.2 

    10 DOTS entries:

    DT.100790569  DT.452111  DT.92451864  DT.100790568  DT.40306234  DT.86999872  DT.92451870  DT.95201664 
    DT.92451869  DT.121421244 

    Selected AceView cDNA sequences (see all 383):

    F36860 AA725846 BM710884 W32638 AA527577 BG338443 AA308801 AA913952 
    BC006554 NM_031901 H66522 AI743076 BI772159 AW245314 BG231789 AW006019 
    BG105196 BC004566 NM_018997 AI092499 CB108185 H67492 H87905 AI961571 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRPS21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGCAAAAA
    MRPS21 Expression
    About this image

    MRPS21 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRPS21 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.405880
        Custom PCR Arrays for MRPS21
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat MRPS21
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MRPS21 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrps211 , 5 mitochondrial ribosomal protein S211, 5 85.06(n)1
    90.8(a)1
      3 (41.36 cM)5
    662921  NM_078479.31  NP_510964.11 
     958626345 
    chicken
    (Gallus gallus)
    Aves MRPS211 mitochondrial ribosomal protein S21 67.43(n)
    70.11(a)
      426666  NM_001277967.1  NP_001264896.1 
    lizard
    (Anolis carolinensis)
    Reptilia MRPS216
    mitochondrial ribosomal protein S21
    77(a)
    1 ↔ 1
    GL343802.1(16736-24810)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW642141.12   -- 75.16(n)    AW642141.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mrps211 mitochondrial ribosomal protein S21 61.3(n)
    60.92(a)
      100073334  NM_001159838.2  NP_001153310.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpS211 mitochondrial ribosomal protein S21 53.33(n)
    50.59(a)
      318249  NM_001275606.1  NP_001262535.1 
    worm
    (Caenorhabditis elegans)
    Secernentea mrps-216
    Protein MRPS-21 (mrps-21) mRNA, complete cds
    30(a)
    1 ↔ 1
    IV(4659049-4659517) WBGene00017924


    ENSEMBL Gene Tree for MRPS21 (if available)
    TreeFam Gene Tree for MRPS21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MRPS21 gene

    MRPS21 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for MRPS21 (see all 7)
    PGOHUM00000238964 PGOHUM00000249126 PGOHUM00000249127 PGOHUM00000237105 PGOHUM00000244058


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MRPS21 (see all 374)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1903499551,2
    --150264307(+) AAATAC/GAGTGA 2 -- us2k10--------
    rs168357801,2
    C,F,H--150264311(+) AGAGTG/TAGTCT 2 -- us2k1 tfbs315Minor allele frequency- T:0.19NA NS EA CSA WA 809
    rs1820194021,2
    --150264385(+) AATTCC/GGCCAT 2 -- us2k10--------
    rs769122891,2
    F--150264534(+) TCAAGG/ATCATA 2 -- us2k11Minor allele frequency- A:0.03EA 120
    rs1147800101,2
    F--150264611(+) CACATT/CATGCT 2 -- us2k11Minor allele frequency- C:0.04WA 118
    rs1499491721,2
    C--150264668(+) TGGAG-/TTTCAC 2 -- us2k10--------
    rs49264191,2
    C,F,A,H--150264714(+) tcggcC/Tcactg 2 -- us2k19Minor allele frequency- T:0.33NA WA CSA 18
    rs1402594681,2
    --150264727(+) ACCTCC/TGCCTC 2 -- us2k10--------
    rs1452451861,2
    --150264843(+) ACCATA/GTTGGC 2 -- us2k10--------
    rs1425209481,2
    C--150264852(+) CCAGG-/CGCTGG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for MRPS21 (150266269 - 150281414 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for MRPS21:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831548CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRPS21
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPS21

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611984    OMIM disorders: --

    1 disease for MRPS21:    
    About MalaCards
    malaria


    MRPS21 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRPS21
    Human Genome Epidemiology (HuGE) Navigator: MRPS21 (1 document)

    Export disorders for MRPS21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRPS21 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with MRPS21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041)1, 2 Suzuki T....Watanabe K. (J. Biol. Chem. 2001)
    4. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2 Koc E.C.... Spremulli L.L. (J. Biol. Chem. 2001)
    5. A genome-wide association study of behavioral disinhibition. (PubMed id 23942779)1 McGue M....Iacono W.G. (Behav. Genet. 2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (EMBO J. 2010)
    10. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54460 HGNC: 14046 AceView: MRPS21 Ensembl:ENSG00000187145 euGenes: HUgn54460
    ECgene: MRPS21 Kegg: 54460 H-InvDB: MRPS21

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRPS21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MRPS21 gene:
    Search GeneIP for patents involving MRPS21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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