MRPS2 Gene
protein-coding GIFtS: 47
GCID: GC09P138391
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mitochondrial ribosomal protein S2
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Aliases
for MRPS2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein S21 2 | | MRP-S22 3 | | S2mt2 3 | | CGI-911 | | 28S Ribosomal Protein S2, Mitochondrial2 |
Export aliases for MRPS2 gene to outside databasesPrevious GC identifers: GC09P129542 GC09P130164 GC09P131914 GC09P133831 GC09P135618 GC09P137531 GC09P107854 |
Summaries
for MRPS2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPS2:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit proteinthat belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for thisgene. (provided by RefSeq, May 2012)
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Genomic Views
for MRPS2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_019501.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPS2 gene promoter:
GR RP58 FOXF2 MyoD NF-kappaB N-Myc CP2 GR-alpha NF-kappaB1 Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPS2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34 Ensembl cytogenetic band: 9q34.3 HGNC cytogenetic band: 9q34MRPS2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P138391: view genomic region
(about GC identifiers)
Start:
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138,391,830 bp from pter |
End:
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138,396,519 bp from pter |
Size:
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4,690 bases |
Orientation:
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plus strand |
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Proteins
for MRPS2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RT02_HUMAN, Q9Y399 (See
protein sequence)Recommended Name: 28S ribosomal protein S2, mitochondrial Size: 296 amino acids; 33249 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinctproteins
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAH04905.2; Type=Erroneous translation; Note=Wrong choice of frame;
Secondary accessions: Q5T899 Q9BSQ4Explore the universe of human proteins at neXtProt for MRPS2: NX_Q9Y399
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y399
MRPS2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057118.1
ENSEMBL proteins: ENSP00000360850 ENSP00000400082 ENSP00000241600
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- | | GO:0015935 | small ribosomal subunit |
IEA | -- |
MRPS2 for ontologies About GeneDecksing
MRPS2 Antibody Products:
Assay Products for MRPS2: |
Protein
Domains /
Families
for MRPS2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPS2 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y399ProtoNet protein and cluster: Q9Y399 1 Blocks protein family: IPB001865 Ribosomal protein S2
UniProtKB/Swiss-Prot: RT02_HUMAN, Q9Y399Similarity: Belongs to the ribosomal protein S2P family |
Function
for MRPS2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRPS2 (NM_015084) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
IEA | -- |
MRPS2 for ontologies About GeneDecksing
|
Pathways & Interactions
for MRPS2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/264 Interacting proteins for MRPS2 (Q9Y3992, 3 ENSP000002416004) via UniProtKB, MINT, STRING, and/or I2D (see all 264)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006412 | translation |
IEA | -- |
MRPS2 for ontologies About GeneDecksing
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Drugs & Compounds
for MRPS2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPS2
Search CenterWatch for drugs/clinical trials and news about MRPS2 / RT02
|
Transcripts
for MRPS2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPS2 gene: NM_016034.4 Unigene Cluster for MRPS2: Mitochondrial ribosomal protein S2 Hs.382044 [show with all ESTs]Unigene Representative Sequence: NR_0519698 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371785(uc004cfv.4) ENST00000488610 ENST00000485333 ENST00000462948
ENST00000472852 ENST00000453385 ENST00000472946 ENST00000241600
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRPS2 (NM_015084) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS2 |
Additional cDNA sequence: AB055388.1 AF151849.1 BC004905.2 BC008017.1 BC013108.2 NR_051967.1 NR_051968.1 NR_051969.1 NR_051970.1 14 DOTS entries: DT.455463 DT.99989597 DT.100695107 DT.100843652 DT.99965338 DT.121186093 DT.92445672 DT.100843653 DT.121186091 DT.91658234 DT.92445673 DT.95350735 DT.101960003 DT.121186086 24/351 AceView cDNA sequences (see all 351): BE251869 BM563025 AI580861 CR616508 BM761008 CR618613 AW328212 CB154951 BQ684726 BM742481 BQ933141 CR601906 BE618928 BF477387 CR590268 CR608447 AI859165 CR603788 BU169388 BE392342 BU684573 BU164397 CR603007 BU521566
GeneLoc Exon Structure
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Expression
for MRPS2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCAGAACGG
About this image
See MRPS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPS2
SOURCE GeneReport for Unigene cluster: Hs.382044
SABiosciences Custom PCR Arrays for MRPS2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPS2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS2 |
Orthologs
for MRPS2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MRPS2 gene from 9/29 species (see all 29) About this table
ENSEMBL Gene Tree for MRPS2 (if available)
TreeFam Gene Tree for MRPS2 (if available) |
Paralogs
for MRPS2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MRPS2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPS2 (138391830 - 138396519 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MRPS2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS2 |
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Disorders
/ Diseases
for MRPS2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRPS2 for disorders About GeneDecksing
OMIM gene information: 611971
OMIM disorders: --
3  diseases for MRPS2: About MalaCardspneumonia tuberculosis mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: MRPS2 (1 document)
Export disorders for MRPS2 gene to outside databases
|
Publications
for MRPS2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPS2 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with MRPS2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041)1, 2 Suzuki T....Watanabe K. (2001)
- The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2 Koc E.C.... Spremulli L.L. (2001)
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
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External Searches for MRPS2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MRPS2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPS2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPS2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPS2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MRPS2 gene:
Search GeneIP for patents involving MRPS2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPS2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for MRPS2 | | OriGene shRNA RFP for MRPS2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPS2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS2 | | | OriGene Protein Over-expression Lysate for MRPS2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRPS2 | | OriGene 3'-UTR Clone for MRPS2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MRPS2 | | OriGene Custom Protein Services for MRPS2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPS2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPS2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS2 |
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| | | | Search Tocris compounds for MRPS2 |
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 | | | MRPS2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS2 |
|  |  |  | | | | Search ThermoFisher Antibodies for MRPS2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS2 |
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