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Aliases for MRPS2 Gene

Aliases for MRPS2 Gene

  • Mitochondrial Ribosomal Protein S2 2 3
  • MRP-S2 3 4
  • S2mt 3 4
  • 28S Ribosomal Protein S2, Mitochondrial 3
  • CGI-91 3

External Ids for MRPS2 Gene

Summaries for MRPS2 Gene

Entrez Gene Summary for MRPS2 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for MRPS2 Gene

MRPS2 (Mitochondrial Ribosomal Protein S2) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS2 Gene

Genomics for MRPS2 Gene

Genomic Location for MRPS2 Gene

Start:
135,499,984 bp from pter
End:
135,504,673 bp from pter
Size:
4,690 bases
Orientation:
Plus strand

Genomic View for MRPS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS2 Gene

Regulatory Elements for MRPS2 Gene

Proteins for MRPS2 Gene

  • Protein details for MRPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y399-RT02_HUMAN
    Recommended name:
    28S ribosomal protein S2, mitochondrial
    Protein Accession:
    Q9Y399
    Secondary Accessions:
    • Q5T899
    • Q9BSQ4

    Protein attributes for MRPS2 Gene

    Size:
    296 amino acids
    Molecular mass:
    33249 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins
    SequenceCaution:
    • Sequence=AAH04905.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

neXtProt entry for MRPS2 Gene

Proteomics data for MRPS2 Gene at MOPED

Post-translational modifications for MRPS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS2 Gene

Domains for MRPS2 Gene

Gene Families for MRPS2 Gene

HGNC:
  • MRPS :Mitochondrial ribosomal proteins / small subunits

Graphical View of Domain Structure for InterPro Entry

Q9Y399

UniProtKB/Swiss-Prot:

RT02_HUMAN
Family:
  • Belongs to the ribosomal protein S2P family.:
    • Q9Y399
genes like me logo Genes that share domains with MRPS2: view

Function for MRPS2 Gene

Gene Ontology (GO) - Molecular Function for MRPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
genes like me logo Genes that share ontologies with MRPS2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPS2 Gene

Localization for MRPS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS2 Gene COMPARTMENTS Subcellular localization image for MRPS2 gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion IDA --
GO:0005763 mitochondrial small ribosomal subunit IBA --
GO:0005840 ribosome --
GO:0015935 small ribosomal subunit --
genes like me logo Genes that share ontologies with MRPS2: view

Pathways for MRPS2 Gene

SuperPathways for MRPS2 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with MRPS2: view

Pathways by source for MRPS2 Gene

1 KEGG pathway for MRPS2 Gene

Gene Ontology (GO) - Biological Process for MRPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006412 translation IBA --
GO:0098779 activation of mitophagy in response to mitochondrial depolarization IMP 22020285
genes like me logo Genes that share ontologies with MRPS2: view

Transcripts for MRPS2 Gene

Unigene Clusters for MRPS2 Gene

Mitochondrial ribosomal protein S2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS2 Gene

No ASD Table

Relevant External Links for MRPS2 Gene

GeneLoc Exon Structure for
MRPS2
ECgene alternative splicing isoforms for
MRPS2

Expression for MRPS2 Gene

mRNA expression in normal human tissues for MRPS2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS2 Gene

SOURCE GeneReport for Unigene cluster for MRPS2 Gene Hs.382044

genes like me logo Genes that share expressions with MRPS2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS2 Gene

Orthologs for MRPS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS2 35
  • 98.76 (n)
  • 98.31 (a)
MRPS2 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPS2 35
  • 81.57 (n)
  • 80.68 (a)
MRPS2 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS2 35
  • 80.65 (n)
  • 75.27 (a)
MRPS2 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrps2 35
  • 77.13 (n)
  • 72.76 (a)
Mrps2 16
Mrps2 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPS2 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS2 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps2 35
  • 75.63 (n)
  • 71.38 (a)
chicken
(Gallus gallus)
Aves MRPS2 35
  • 74.47 (n)
  • 69.15 (a)
MRPS2 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11005 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps2 35
  • 71.01 (n)
  • 69.75 (a)
Str.9076 35
zebrafish
(Danio rerio)
Actinopterygii mrps2 35
  • 65.95 (n)
  • 66.81 (a)
mrps2 36
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011886 35
  • 62.87 (n)
  • 59.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS2 35
  • 63.07 (n)
  • 61.27 (a)
mRpS2 36
  • 50 (a)
OneToOne
mRpS2 37
  • 61 (a)
worm
(Caenorhabditis elegans)
Secernentea mrps-2 35
  • 48.37 (n)
  • 42.65 (a)
mrps-2 36
  • 31 (a)
OneToOne
T23B12.3 37
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRP4 36
  • 19 (a)
OneToOne
MRP4 38
Species with no ortholog for MRPS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS2 Gene

ENSEMBL:
Gene Tree for MRPS2 (if available)
TreeFam:
Gene Tree for MRPS2 (if available)

Paralogs for MRPS2 Gene

No data available for Paralogs for MRPS2 Gene

Variants for MRPS2 Gene

Sequence variations from dbSNP and Humsavar for MRPS2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs55642785 -- 135,502,291(+) GCTGG(A/G)CCTTC intron-variant
rs58312267 -- 135,502,626(+) AGCTT(C/G)GTTCC intron-variant
rs77168510 -- 135,502,517(+) GGGGT(A/G)GGAGG intron-variant
rs80015265 -- 135,502,278(+) CCCCC(C/T)GGATC intron-variant
rs80220183 -- 135,502,585(+) CTGAG(A/G)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS2 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
nsv894247 CNV Gain 21882294
nsv469913 CNV Loss 18288195
dgv8366n71 CNV Loss 21882294
dgv8367n71 CNV Loss 21882294
nsv894253 CNV Loss 21882294
nsv825164 CNV Gain 20364138
nsv466656 CNV Gain 19166990

Relevant External Links for MRPS2 Gene

HapMap Linkage Disequilibrium report
MRPS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS2 Gene

Disorders for MRPS2 Gene

Relevant External Links for MRPS2

Genetic Association Database (GAD)
MRPS2
Human Genome Epidemiology (HuGE) Navigator
MRPS2
genes like me logo Genes that share disorders with MRPS2: view

No data available for UniProtKB/Swiss-Prot for MRPS2 Gene

Publications for MRPS2 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 3 4
  3. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 3 4
  4. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PMID: 11402041) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MRPS2 Gene

Sources for MRPS2 Gene

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