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Aliases for MRPS2 Gene

Aliases for MRPS2 Gene

  • Mitochondrial Ribosomal Protein S2 2 3 5
  • MRP-S2 3 4
  • S2mt 3 4
  • CGI-91 3

External Ids for MRPS2 Gene

Previous GeneCards Identifiers for MRPS2 Gene

  • GC09P129542
  • GC09P130164
  • GC09P131914
  • GC09P133831
  • GC09P135618
  • GC09P137531
  • GC09P138391
  • GC09P107854

Summaries for MRPS2 Gene

Entrez Gene Summary for MRPS2 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for MRPS2 Gene

MRPS2 (Mitochondrial Ribosomal Protein S2) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS2 Gene

Genomics for MRPS2 Gene

Regulatory Elements for MRPS2 Gene

Enhancers for MRPS2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPS2 on UCSC Golden Path with GeneCards custom track

Promoters for MRPS2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPS2 Gene

135,499,984 bp from pter
135,504,673 bp from pter
4,690 bases
Plus strand

Genomic View for MRPS2 Gene

Genes around MRPS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS2 Gene

Proteins for MRPS2 Gene

  • Protein details for MRPS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S2, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q5T899
    • Q9BSQ4

    Protein attributes for MRPS2 Gene

    296 amino acids
    Molecular mass:
    33249 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
    • Sequence=AAH04905.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS2 Gene

neXtProt entry for MRPS2 Gene

Proteomics data for MRPS2 Gene at MOPED

Post-translational modifications for MRPS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS2 Gene

Domains & Families for MRPS2 Gene

Gene Families for MRPS2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S2P family.
  • Belongs to the ribosomal protein S2P family.
genes like me logo Genes that share domains with MRPS2: view

Function for MRPS2 Gene

genes like me logo Genes that share phenotypes with MRPS2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS2 Gene

Localization for MRPS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS2 Gene


Subcellular locations from

Jensen Localization Image for MRPS2 Gene COMPARTMENTS Subcellular localization image for MRPS2 gene
Compartment Confidence
mitochondrion 5
endoplasmic reticulum 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS2: view

Pathways & Interactions for MRPS2 Gene

SuperPathways for MRPS2 Gene

Superpath Contained pathways
1 Viral mRNA Translation
genes like me logo Genes that share pathways with MRPS2: view

Pathways by source for MRPS2 Gene

1 KEGG pathway for MRPS2 Gene

Gene Ontology (GO) - Biological Process for MRPS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
GO:0098792 xenophagy IMP 22020285
genes like me logo Genes that share ontologies with MRPS2: view

No data available for SIGNOR curated interactions for MRPS2 Gene

Drugs & Compounds for MRPS2 Gene

No Compound Related Data Available

Transcripts for MRPS2 Gene

Unigene Clusters for MRPS2 Gene

Mitochondrial ribosomal protein S2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS2 Gene

No ASD Table

Relevant External Links for MRPS2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS2 Gene

mRNA expression in normal human tissues for MRPS2 Gene

Protein differential expression in normal tissues from HIPED for MRPS2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.3) and Heart (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS2 Gene

SOURCE GeneReport for Unigene cluster for MRPS2 Gene Hs.382044

genes like me logo Genes that share expression patterns with MRPS2: view

Protein tissue co-expression partners for MRPS2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS2 Gene

Orthologs for MRPS2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS2 35
  • 81.57 (n)
  • 80.68 (a)
MRPS2 36
  • 72 (a)
(Canis familiaris)
Mammalia MRPS2 35
  • 80.65 (n)
  • 75.27 (a)
MRPS2 36
  • 61 (a)
(Mus musculus)
Mammalia Mrps2 35
  • 77.13 (n)
  • 72.76 (a)
Mrps2 16
Mrps2 36
  • 72 (a)
(Pan troglodytes)
Mammalia MRPS2 35
  • 98.76 (n)
  • 98.31 (a)
MRPS2 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Mrps2 35
  • 75.63 (n)
  • 71.38 (a)
(Monodelphis domestica)
Mammalia MRPS2 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS2 36
  • 50 (a)
(Gallus gallus)
Aves MRPS2 35
  • 74.47 (n)
  • 69.15 (a)
MRPS2 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps2 35
  • 71.01 (n)
  • 69.75 (a)
Str.9076 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.11005 35
(Danio rerio)
Actinopterygii mrps2 35
  • 65.95 (n)
  • 66.81 (a)
mrps2 36
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS2 37
  • 61 (a)
mRpS2 35
  • 63.07 (n)
  • 61.27 (a)
mRpS2 36
  • 50 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011886 35
  • 62.87 (n)
  • 59.9 (a)
(Caenorhabditis elegans)
Secernentea T23B12.3 37
  • 42 (a)
mrps-2 35
  • 48.37 (n)
  • 42.65 (a)
mrps-2 36
  • 31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRP4 36
  • 19 (a)
MRP4 38
Species with no ortholog for MRPS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS2 Gene

Gene Tree for MRPS2 (if available)
Gene Tree for MRPS2 (if available)

Paralogs for MRPS2 Gene

No data available for Paralogs for MRPS2 Gene

Variants for MRPS2 Gene

Sequence variations from dbSNP and Humsavar for MRPS2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_020128 -
VAR_034479 -
VAR_034480 -

Structural Variations from Database of Genomic Variants (DGV) for MRPS2 Gene

Variant ID Type Subtype PubMed ID
esv2739138 CNV Deletion 23290073
nsv894247 CNV Gain 21882294
nsv469913 CNV Loss 18288195
dgv8366n71 CNV Loss 21882294
dgv8367n71 CNV Loss 21882294
nsv894253 CNV Loss 21882294
nsv825164 CNV Gain 20364138
nsv466656 CNV Gain 19166990

Variation tolerance for MRPS2 Gene

Residual Variation Intolerance Score: 60.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.00; 60.14% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRPS2 Gene

Disorders for MRPS2 Gene

Relevant External Links for MRPS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS2 Gene

Publications for MRPS2 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for MRPS2 Gene

Sources for MRPS2 Gene