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Aliases for MRPS18C Gene

Aliases for MRPS18C Gene

  • Mitochondrial Ribosomal Protein S18C 2 3 5
  • 28S Ribosomal Protein S18-1, Mitochondrial 3 4
  • MRP-S18-1 3 4
  • MRP-S18-C 3 4
  • Mrps18-C 3 4
  • S18mt-C 3 4
  • 28S Ribosomal Protein S18c, Mitochondrial 3
  • Mitochondrial Ribosomal Protein S18-1 3
  • MRPS18-1 3
  • CGI-134 3

External Ids for MRPS18C Gene

Previous GeneCards Identifiers for MRPS18C Gene

  • GC04P084301
  • GC04P084670
  • GC04P084835
  • GC04P084734
  • GC04P084596
  • GC04P080119

Summaries for MRPS18C Gene

Entrez Gene Summary for MRPS18C Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 8p, 12p, 15q, and 22q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS18C Gene

MRPS18C (Mitochondrial Ribosomal Protein S18C) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS18C Gene

Genomics for MRPS18C Gene

Regulatory Elements for MRPS18C Gene

Enhancers for MRPS18C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F083484 0.6 ENCODE 12.2 +29.2 29216 2.3 HDGF ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 HELQ MRPS18C GPAT3 FAM175A SLC25A14P1 RPL30P5
GH04F083477 0.7 FANTOM5 11.7 +21.7 21723 0.4 MRPS18C GPAT3 SLC25A14P1 RPL30P5
GH04F083535 0.2 ENCODE 11.5 +80.5 80512 2.8 ATF1 PKNOX1 CREB3L1 SIN3A DMAP1 ZNF48 YY1 ZNF121 GLIS2 ZNF548 HELQ MRPS18C GPAT3 ENSG00000201633 GC04M083639
GH04F083504 0.9 Ensembl ENCODE 11 +48.8 48821 1.1 ZNF316 GATA3 GPAT3 MRPS18C RPL30P5 FAM175A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MRPS18C on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPS18C Gene

83,455,932 bp from pter
83,469,735 bp from pter
13,804 bases
Plus strand

Genomic View for MRPS18C Gene

Genes around MRPS18C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS18C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS18C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS18C Gene

Proteins for MRPS18C Gene

  • Protein details for MRPS18C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S18c, mitochondrial
    Protein Accession:

    Protein attributes for MRPS18C Gene

    142 amino acids
    Molecular mass:
    15850 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS18C Gene

neXtProt entry for MRPS18C Gene

Post-translational modifications for MRPS18C Gene

  • Ubiquitination at Lys 125
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS18C Gene

No data available for DME Specific Peptides for MRPS18C Gene

Domains & Families for MRPS18C Gene

Gene Families for MRPS18C Gene

Protein Domains for MRPS18C Gene

Suggested Antigen Peptide Sequences for MRPS18C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S18P family.
  • Belongs to the ribosomal protein S18P family.
genes like me logo Genes that share domains with MRPS18C: view

Function for MRPS18C Gene

Gene Ontology (GO) - Molecular Function for MRPS18C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
genes like me logo Genes that share ontologies with MRPS18C: view
genes like me logo Genes that share phenotypes with MRPS18C: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS18C Gene

Localization for MRPS18C Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS18C Gene


Subcellular locations from

Jensen Localization Image for MRPS18C Gene COMPARTMENTS Subcellular localization image for MRPS18C gene
Compartment Confidence
mitochondrion 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPS18C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IDA 11279123
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS18C: view

Pathways & Interactions for MRPS18C Gene

genes like me logo Genes that share pathways with MRPS18C: view

Gene Ontology (GO) - Biological Process for MRPS18C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,NAS 11279123
GO:0032543 mitochondrial translation IBA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS18C: view

No data available for SIGNOR curated interactions for MRPS18C Gene

Transcripts for MRPS18C Gene

Unigene Clusters for MRPS18C Gene

Mitochondrial ribosomal protein S18C:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS18C Gene

No ASD Table

Relevant External Links for MRPS18C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS18C Gene

mRNA expression in normal human tissues for MRPS18C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS18C Gene

This gene is overexpressed in Liver (67.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS18C Gene

Protein tissue co-expression partners for MRPS18C Gene

NURSA nuclear receptor signaling pathways regulating expression of MRPS18C Gene:


SOURCE GeneReport for Unigene cluster for MRPS18C Gene:

genes like me logo Genes that share expression patterns with MRPS18C: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS18C Gene

Orthologs for MRPS18C Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS18C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPS18C 34 35
  • 99.77 (n)
(Canis familiaris)
Mammalia MRPS18C 34
  • 90.31 (n)
(Bos Taurus)
Mammalia MRPS18C 34 35
  • 87.94 (n)
(Mus musculus)
Mammalia Mrps18c 34 16 35
  • 86.09 (n)
(Rattus norvegicus)
Mammalia Mrps18c 34
  • 84.41 (n)
(Monodelphis domestica)
Mammalia MRPS18C 35
  • 73 (a)
(Gallus gallus)
Aves MRPS18C 34 35
  • 65.64 (n)
(Anolis carolinensis)
Reptilia MRPS18C 35
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps18c 34
  • 64.81 (n)
Str.416 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.20569 34
(Danio rerio)
Actinopterygii mrps18c 34 35
  • 64.69 (n)
Dr.14273 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12181 34
fruit fly
(Drosophila melanogaster)
Insecta mRpS18C 34 35
  • 53.76 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008773 34
  • 53.05 (n)
(Caenorhabditis elegans)
Secernentea T14B4.2 34 35
  • 57.25 (n)
Species where no ortholog for MRPS18C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS18C Gene

Gene Tree for MRPS18C (if available)
Gene Tree for MRPS18C (if available)

Paralogs for MRPS18C Gene

genes like me logo Genes that share paralogs with MRPS18C: view

No data available for Paralogs for MRPS18C Gene

Variants for MRPS18C Gene

Sequence variations from dbSNP and Humsavar for MRPS18C Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10516687 -- 83,455,290(+) AACAG(C/T)GGTAA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs10516688 -- 83,455,828(+) CAGGG(A/C)TCGCG nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs11099601 -- 83,461,610(+) GTCTA(C/T)CCTCA utr-variant-3-prime
rs111266400 -- 83,459,649(+) GCTTT(A/G)TATAA intron-variant, utr-variant-3-prime
rs111297501 -- 83,458,837(+) GGCAA(A/G)TGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS18C Gene

Variant ID Type Subtype PubMed ID
esv3601196 CNV loss 21293372
esv3601197 CNV loss 21293372
esv3893971 CNV gain 25118596
nsv829992 CNV loss 17160897
nsv829994 CNV loss 17160897

Variation tolerance for MRPS18C Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS18C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS18C Gene

Disorders for MRPS18C Gene

Relevant External Links for MRPS18C

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPS18C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS18C Gene

Publications for MRPS18C Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4 64
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MRPS18C Gene

Sources for MRPS18C Gene

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