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Aliases for MRPS18C Gene

Aliases for MRPS18C Gene

  • Mitochondrial Ribosomal Protein S18C 2 3 5
  • 28S Ribosomal Protein S18-1, Mitochondrial 3 4
  • MRP-S18-1 3 4
  • MRP-S18-C 3 4
  • Mrps18-C 3 4
  • S18mt-C 3 4
  • Mitochondrial Ribosomal Protein S18-1 3
  • MRPS18-1 3
  • CGI-134 3

External Ids for MRPS18C Gene

Previous GeneCards Identifiers for MRPS18C Gene

  • GC04P084301
  • GC04P084670
  • GC04P084835
  • GC04P084734
  • GC04P084596
  • GC04P080119

Summaries for MRPS18C Gene

Entrez Gene Summary for MRPS18C Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 8p, 12p, 15q, and 22q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS18C Gene

MRPS18C (Mitochondrial Ribosomal Protein S18C) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS18C Gene

Genomics for MRPS18C Gene

Regulatory Elements for MRPS18C Gene

Enhancers for MRPS18C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPS18C on UCSC Golden Path with GeneCards custom track

Promoters for MRPS18C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPS18C on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPS18C Gene

Chromosome:
4
Start:
83,455,932 bp from pter
End:
83,469,735 bp from pter
Size:
13,804 bases
Orientation:
Plus strand

Genomic View for MRPS18C Gene

Genes around MRPS18C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS18C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS18C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS18C Gene

Proteins for MRPS18C Gene

  • Protein details for MRPS18C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3D5-RT18C_HUMAN
    Recommended name:
    28S ribosomal protein S18c, mitochondrial
    Protein Accession:
    Q9Y3D5

    Protein attributes for MRPS18C Gene

    Size:
    142 amino acids
    Molecular mass:
    15850 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS18C Gene

neXtProt entry for MRPS18C Gene

Proteomics data for MRPS18C Gene at MOPED

Post-translational modifications for MRPS18C Gene

  • Ubiquitination at Lys 125
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS18C Gene

Antibody Products

No data available for DME Specific Peptides for MRPS18C Gene

Domains & Families for MRPS18C Gene

Gene Families for MRPS18C Gene

Protein Domains for MRPS18C Gene

Suggested Antigen Peptide Sequences for MRPS18C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y3D5

UniProtKB/Swiss-Prot:

RT18C_HUMAN :
  • Belongs to the ribosomal protein S18P family.
Family:
  • Belongs to the ribosomal protein S18P family.
genes like me logo Genes that share domains with MRPS18C: view

Function for MRPS18C Gene

Phenotypes for MRPS18C Gene

genes like me logo Genes that share phenotypes with MRPS18C: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS18C Gene

Localization for MRPS18C Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS18C Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS18C Gene COMPARTMENTS Subcellular localization image for MRPS18C gene
Compartment Confidence
mitochondrion 5
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPS18C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPS18C: view

Pathways & Interactions for MRPS18C Gene

genes like me logo Genes that share pathways with MRPS18C: view

Interacting Proteins for MRPS18C Gene

Gene Ontology (GO) - Biological Process for MRPS18C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,NAS 11279123
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPS18C: view

No data available for SIGNOR curated interactions for MRPS18C Gene

Drugs & Compounds for MRPS18C Gene

No Compound Related Data Available

Transcripts for MRPS18C Gene

Unigene Clusters for MRPS18C Gene

Mitochondrial ribosomal protein S18C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS18C Gene

No ASD Table

Relevant External Links for MRPS18C Gene

GeneLoc Exon Structure for
MRPS18C
ECgene alternative splicing isoforms for
MRPS18C

Expression for MRPS18C Gene

mRNA expression in normal human tissues for MRPS18C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS18C Gene

This gene is overexpressed in Liver (67.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS18C Gene



SOURCE GeneReport for Unigene cluster for MRPS18C Gene Hs.436161

genes like me logo Genes that share expression patterns with MRPS18C: view

Protein tissue co-expression partners for MRPS18C Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS18C Gene

Orthologs for MRPS18C Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS18C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPS18C 35
  • 87.94 (n)
  • 82.98 (a)
MRPS18C 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS18C 35
  • 90.31 (n)
  • 83.69 (a)
mouse
(Mus musculus)
Mammalia Mrps18c 35
  • 86.09 (n)
  • 82.01 (a)
Mrps18c 16
Mrps18c 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPS18C 35
  • 99.77 (n)
  • 100 (a)
MRPS18C 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps18c 35
  • 84.41 (n)
  • 79.86 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPS18C 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS18C 35
  • 65.64 (n)
  • 61.54 (a)
MRPS18C 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPS18C 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps18c 35
  • 64.81 (n)
  • 64.29 (a)
Str.416 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.20569 35
zebrafish
(Danio rerio)
Actinopterygii Dr.14273 35
mrps18c 35
  • 64.69 (n)
  • 64.36 (a)
mrps18c 36
  • 48 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12181 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008773 35
  • 53.05 (n)
  • 47.31 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS18C 35
  • 53.76 (n)
  • 53.76 (a)
mRpS18C 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T14B4.2 35
  • 57.25 (n)
  • 48.91 (a)
T14B4.2 36
  • 35 (a)
OneToOne
Species with no ortholog for MRPS18C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS18C Gene

ENSEMBL:
Gene Tree for MRPS18C (if available)
TreeFam:
Gene Tree for MRPS18C (if available)

Paralogs for MRPS18C Gene

genes like me logo Genes that share paralogs with MRPS18C: view

No data available for Paralogs for MRPS18C Gene

Variants for MRPS18C Gene

Sequence variations from dbSNP and Humsavar for MRPS18C Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs6852306 -- 83,458,567(+) TTATA(A/G)TTCTA intron-variant
rs11397235 -- 83,458,646(+) CTCTG(-/T)TTTTT intron-variant
rs12505955 -- 83,459,802(+) GGTAT(G/T)TTCTT intron-variant
rs11449455 -- 83,459,225(+) CCAAG(-/A)AATTA intron-variant
rs13142756 -- 83,460,344(+) GAGAT(G/T)GGGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS18C Gene

Variant ID Type Subtype PubMed ID
nsv829992 CNV Loss 17160897
nsv829994 CNV Loss 17160897
nsv879512 CNV Gain 21882294

Variation tolerance for MRPS18C Gene

Residual Variation Intolerance Score: 57.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRPS18C Gene

Disorders for MRPS18C Gene

Relevant External Links for MRPS18C

Genetic Association Database (GAD)
MRPS18C
Human Genome Epidemiology (HuGE) Navigator
MRPS18C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS18C

No disorders were found for MRPS18C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS18C Gene

Publications for MRPS18C Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4 67
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3

Products for MRPS18C Gene

Sources for MRPS18C Gene

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