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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRPS18C Gene

protein-coding   GIFtS: 44
GCID: GC04P084301

mitochondrial ribosomal protein S18C

  Search for MRPS18C
in our new
 Human Malady Compendium 
Biological research products
for MRPS18C
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mitochondrial Ribosomal Protein S18C1 2     FLJ111461
MRPS18-11 2 5     FLJ229671
28S Ribosomal Protein S18-1, Mitochondrial2 3     28S Ribosomal Protein S18c, Mitochondrial2
MRP-S18-12 3     Mitochondrial Ribosomal Protein S18-12
MRP-S18-C1     Mrps18-C1
S18mt-C1     Mrps18-C1
CGI-1341     

External Ids:    HGNC: 166331   Entrez Gene: 510232   Ensembl: ENSG000001633197   OMIM: 6119835   UniProtKB: Q9Y3D53   

Export aliases for MRPS18C gene to outside databases

Previous GC identifers: GC04P084670 GC04P084835 GC04P084734 GC04P084596 GC04P080119


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRPS18C:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They
have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.
Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.
Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in
biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein
that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence
similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more
closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene
are found on chromosomes 8p, 12p, 15q, and 22q. (provided by RefSeq, Jul 2008)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRPS18C gene promoter:
         AhR   AML1a   FOXF2   p53   Pax-6   NF-kappaB   GATA-1   Arnt   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPS18C promoter sequence
   Search SABiosciences Chromatin IP Primers for MRPS18C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS18C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q21.23   Ensembl cytogenetic band:  4q21.23   HGNC cytogenetic band: 4q21.21-q21.23

MRPS18C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPS18C gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P084301:  view genomic region     (about GC identifiers)

Start:
84,377,085 bp from pter      End:
84,390,888 bp from pter
Size:
13,804 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RT18C_HUMAN, Q9Y3D5 (See protein sequence)
Recommended Name: 28S ribosomal protein S18c, mitochondrial precursor  
Size: 142 amino acids; 15850 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct
proteins
Subcellular location: Mitochondrion

Explore the universe of human proteins at neXtProt for MRPS18C: NX_Q9Y3D5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y3D5

  • MRPS18C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_057151.1  
    ENSEMBL proteins: 
     ENSP00000295491   ENSP00000427169   ENSP00000426930   ENSP00000427014   ENSP00000425268  

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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005763mitochondrial small ribosomal subunit IDA11279123
    GO:0005840ribosome ----


    MRPS18C for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MRPS18C for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR018275 Ribosomal_S18_CS
     IPR001648 Ribosomal_S18

    Graphical View of Domain Structure for InterPro Entry Q9Y3D5

    ProtoNet protein and cluster: Q9Y3D5

    1 Blocks protein family: IPB001648 Ribosomal protein S18

    UniProtKB/Swiss-Prot: RT18C_HUMAN, Q9Y3D5
    Similarity: Belongs to the ribosomal protein S18P family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    hsa-miR-1283 hsa-miR-3143 hsa-miR-556-5p hsa-miR-543
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    Inhib. RNA
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS11279123


    MRPS18C for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS18C

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for MRPS18C (ENSP000002954914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MRPL42ENSP000003515064STRING: ENSP00000351506
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation NAS11279123


    MRPS18C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRPS18C
    Search CenterWatch for drugs/clinical trials and news about MRPS18C / RT18C 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRPS18C gene: 
    NM_016067.2  

    Unigene Cluster for MRPS18C:

    Mitochondrial ribosomal protein S18C
    Hs.436161  [show with all ESTs]
    Unigene Representative Sequence: NM_016067
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000512375 ENST00000295491(uc003hor.4) ENST00000507019 ENST00000507349
    ENST00000509970 ENST00000505719 ENST00000505525 ENST00000514581 ENST00000509571


    miRNA
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    hsa-miR-1283 hsa-miR-3143 hsa-miR-556-5p hsa-miR-543
    SwitchGear 3'UTR luciferase reporter plasmidMRPS18C 3' UTR sequence
    Inhib. RNA
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    OriGene siRNA: MRPS18C
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPS18C
    Clone
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    Additional cDNA sequence: 

    AF151892.1 AK026620.1 BC005186.1 

    16 DOTS entries:

    DT.444592  DT.121274550  DT.100789227  DT.75103561  DT.91761919  DT.91909191  DT.91956513  DT.121274496 
    DT.121279941  DT.95247485  DT.121274504  DT.121485911  DT.97804758  DT.100036787  DT.121274495  DT.99988694 

    24/152 AceView cDNA sequences (see all 152):

    W01964 BU542203 BQ013237 AK002008 AI522092 NM_016067 C01486 BM768424 
    T39578 AI476169 BF062776 BU165546 D12141 CR594294 BX281462 AI738767 
    AI696129 AA236425 BE738411 T40674 AI634823 AA853322 AK026620 BM725559 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRPS18C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGATTATAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    MRPS18C expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainChoroid PlexusBrain
    Gut TubeVentral Foregut EndodermGut Tube
    LimbAutopodLimb
    LungTracheaLung
    Neural TubeMetencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See MRPS18C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRPS18C

    SOURCE GeneReport for Unigene cluster: Hs.436161
        SABiosciences Custom PCR Arrays for MRPS18C
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS18C

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MRPS18C gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrps18c1 , 5 mitochondrial ribosomal protein S18C1, 5 86.09(n)1
    82.01(a)1
      5 (48.52 cM)5
    687351  NM_026826.11  NP_081102.11 
     1007986275 
    chicken
    (Gallus gallus)
    Aves MRPS18C1 mitochondrial ribosomal protein S18C 72.9(n)
    71.03(a)
      770813  NM_001252311.1  NP_001239240.1 
    lizard
    (Anolis carolinensis)
    Reptilia MRPS18C6
    --
    73(a)
    1 ↔ 1
    5(43360678-43361941)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.205692 Xenopus laevis transcribed sequence with weak similarity more 84.33(n)    48024520 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.142732 Transcribed sequence with weak similarity to protein more 70.69(n)    57072362 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpS18C1 mitochondrial ribosomal protein S18C 53.85(n)
    54.95(a)
      43609  NM_079854.2  NP_524593.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T14B4.21 Protein T14B4.2 55.09(n)
    48.42(a)
      188492  NM_062973.3  NP_495374.1 


    ENSEMBL Gene Tree for MRPS18C (if available)
    TreeFam Gene Tree for MRPS18C (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRPS18C gene

    MRPS18C for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for MRPS18C (see all 6)
    PGOHUM00000239684 PGOHUM00000251169 PGOHUM00000246350 PGOHUM00000249225 PGOHUM00000249584


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS18C
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPS18C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MRPS18C for disorders           About MalaCards

    MRPS18C for disorders           About GeneDecksing

    OMIM gene information: 611983    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: MRPS18C (2 documents)

    Export disorders for MRPS18C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRPS18C gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with MRPS18C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2, 3 Koc E.C.... Spremulli L.L. (2001)
    2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    9. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51023 HGNC: 16633 AceView: MRPS18C Ensembl:ENSG00000163319 euGenes: HUgn51023
    ECgene: MRPS18C H-InvDB: MRPS18C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRPS18C Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRPS18C gene:
    Search GeneIP for patents involving MRPS18C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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    VWF
    (GIFTS: 73)
    von Willebrand factor
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    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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