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Aliases for MRPS18B Gene

Aliases for MRPS18B Gene

  • Mitochondrial Ribosomal Protein S18B 2 3 5
  • 28S Ribosomal Protein S18-2, Mitochondrial 3 4
  • MRP-S18-2 3 4
  • MRP-S18-B 3 4
  • Mrps18-B 3 4
  • C6orf14 3 4
  • S18mt-B 3 4
  • Mitochondrial Ribosomal Protein S18-2 3
  • HumanS18a 3
  • MRPS18-2 3
  • HSPC183 3
  • PTD017 3
  • S18amt 3

External Ids for MRPS18B Gene

Previous GeneCards Identifiers for MRPS18B Gene

  • GC06P030641
  • GC06P030356
  • GC06P030691
  • GC06P030693
  • GC06P030585
  • GC06P030386

Summaries for MRPS18B Gene

Entrez Gene Summary for MRPS18B Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS18B Gene

MRPS18B (Mitochondrial Ribosomal Protein S18B) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS18B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS18B Gene

Genomics for MRPS18B Gene

Regulatory Elements for MRPS18B Gene

Promoters for MRPS18B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPS18B on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPS18B Gene

30,617,320 bp from pter
30,626,397 bp from pter
9,078 bases
Plus strand

Genomic View for MRPS18B Gene

Genes around MRPS18B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS18B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS18B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MRPS18B Gene

  • Protein details for MRPS18B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S18b, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A6NDQ0
    • Q659G4
    • Q9BS27

    Protein attributes for MRPS18B Gene

    258 amino acids
    Molecular mass:
    29396 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS18B Gene

neXtProt entry for MRPS18B Gene

Proteomics data for MRPS18B Gene at MOPED

Post-translational modifications for MRPS18B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS18B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS18B Gene

Domains & Families for MRPS18B Gene

Gene Families for MRPS18B Gene

Protein Domains for MRPS18B Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S18P family.
  • Belongs to the ribosomal protein S18P family.
genes like me logo Genes that share domains with MRPS18B: view

Function for MRPS18B Gene

Phenotypes for MRPS18B Gene

GenomeRNAi human phenotypes for MRPS18B:
genes like me logo Genes that share phenotypes with MRPS18B: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS18B Gene

Localization for MRPS18B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS18B Gene


Subcellular locations from

Jensen Localization Image for MRPS18B Gene COMPARTMENTS Subcellular localization image for MRPS18B gene
Compartment Confidence
mitochondrion 3
cytosol 2
peroxisome 2
nucleus 1

Gene Ontology (GO) - Cellular Components for MRPS18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA,IDA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPS18B: view

Pathways & Interactions for MRPS18B Gene

genes like me logo Genes that share pathways with MRPS18B: view

Interacting Proteins for MRPS18B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9Y676-RT18B_HUMAN ENSP00000259873 for MRPS18B Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for MRPS18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,NAS 11279123
GO:0006996 organelle organization TAS --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPS18B: view

No data available for SIGNOR curated interactions for MRPS18B Gene

Drugs & Compounds for MRPS18B Gene

No Compound Related Data Available

Transcripts for MRPS18B Gene

Unigene Clusters for MRPS18B Gene

Mitochondrial ribosomal protein S18B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS18B Gene

No ASD Table

Relevant External Links for MRPS18B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS18B Gene

mRNA expression in normal human tissues for MRPS18B Gene

mRNA differential expression in normal tissues according to GTEx for MRPS18B Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for MRPS18B Gene

This gene is overexpressed in Nasal epithelium (20.1), Breast (11.8), and Lavage (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS18B Gene

SOURCE GeneReport for Unigene cluster for MRPS18B Gene Hs.655329

genes like me logo Genes that share expression patterns with MRPS18B: view

Protein tissue co-expression partners for MRPS18B Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MRPS18B Gene

Orthologs for MRPS18B Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS18B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS18B 35
  • 86.18 (n)
  • 84.5 (a)
MRPS18B 36
  • 85 (a)
(Canis familiaris)
Mammalia MRPS18B 35
  • 86.33 (n)
  • 86.61 (a)
MRPS18B 36
  • 84 (a)
(Mus musculus)
Mammalia Mrps18b 35
  • 82.02 (n)
  • 78.74 (a)
Mrps18b 16
Mrps18b 36
  • 78 (a)
(Pan troglodytes)
Mammalia MRPS18B 35
  • 99.74 (n)
  • 99.22 (a)
MRPS18B 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mrps18b 35
  • 81.55 (n)
  • 79.45 (a)
(Monodelphis domestica)
Mammalia MRPS18B 36
  • 73 (a)
(Anolis carolinensis)
Reptilia MRPS18B 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489063 35
  • 54.65 (n)
  • 51.44 (a)
(Danio rerio)
Actinopterygii mrps18b 35
  • 53.21 (n)
  • 48.83 (a)
mrps18b 36
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS18b 37
  • 45 (a)
mRpS18B 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea mrps-18B 36
  • 24 (a)
Species with no ortholog for MRPS18B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS18B Gene

Gene Tree for MRPS18B (if available)
Gene Tree for MRPS18B (if available)

Paralogs for MRPS18B Gene Pseudogenes for MRPS18B Gene

genes like me logo Genes that share paralogs with MRPS18B: view

No data available for Paralogs for MRPS18B Gene

Variants for MRPS18B Gene

Sequence variations from dbSNP and Humsavar for MRPS18B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_052056 -
rs12189738 -- 30,622,296(+) ggtgg(C/T)tcatg intron-variant
rs2252845 -- 30,624,428(+) TGTTG(G/T)GGGTG intron-variant
rs2270172 -- 30,624,637(-) GTAAA(A/G)CCTCC intron-variant
rs2517566 -- 30,622,345(-) GACCT(A/G)GTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS18B Gene

Variant ID Type Subtype PubMed ID
esv2731791 CNV Deletion 23290073
nsv884086 CNV Gain 21882294
esv2670269 CNV Deletion 23128226
nsv884091 CNV Loss 21882294
nsv5244 CNV Loss 18451855
nsv830626 CNV Loss 17160897

Variation tolerance for MRPS18B Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRPS18B Gene

Disorders for MRPS18B Gene

Relevant External Links for MRPS18B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPS18B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS18B Gene

Publications for MRPS18B Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A COFRADIC protocol to study protein ubiquitination. (PMID: 24816145) Stes E. … Gevaert K. (J. Proteome Res. 2014) 3

Products for MRPS18B Gene

Sources for MRPS18B Gene