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Aliases for MRPS18B Gene

Aliases for MRPS18B Gene

  • Mitochondrial Ribosomal Protein S18B 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein BS18b 3 4
  • Mitochondrial Small Ribosomal Subunit Protein MS40 3 4
  • 28S Ribosomal Protein S18-2, Mitochondrial 3 4
  • MRP-S18-2 3 4
  • MRP-S18-B 3 4
  • Mrps18-B 3 4
  • C6orf14 3 4
  • S18mt-B 3 4
  • Mitochondrial Small Ribosomal Subunit Protein BS18m-B 3
  • 28S Ribosomal Protein S18b, Mitochondrial 3
  • Mitochondrial Ribosomal Protein S18-2 3
  • HumanS18a 3
  • MRPS18-2 3
  • HSPC183 3
  • PTD017 3
  • S18amt 3

External Ids for MRPS18B Gene

Previous GeneCards Identifiers for MRPS18B Gene

  • GC06P030641
  • GC06P030356
  • GC06P030691
  • GC06P030693
  • GC06P030585
  • GC06P030386

Summaries for MRPS18B Gene

Entrez Gene Summary for MRPS18B Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS18B Gene

MRPS18B (Mitochondrial Ribosomal Protein S18B) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral carcinogenesis. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS18B Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS18B Gene

Genomics for MRPS18B Gene

Regulatory Elements for MRPS18B Gene

Enhancers for MRPS18B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G030541 1.5 Ensembl ENCODE dbSUPER 11.5 -74.4 -74420 3.7 HDGF PKNOX1 WRNIP1 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 FOS ABCF1 ENSG00000235781 MIR877 MRPS18B PPP1R10 ATAT1 PTMAP1 C6orf136 HLA-C HCG4
GH06G030735 1.4 Ensembl ENCODE dbSUPER 12 +119.8 119790 2.9 HDAC1 HDGF TBP PKNOX1 WRNIP1 BMI1 ZBTB40 GATA2 ZNF366 ELK1 PTMAP1 ATAT1 MRPS18B PPP1R10 MDC1-AS1 PSORS1C2 C6orf136 DHX16 VARS2 TRIM31
GH06G030655 0.7 ENCODE 12.2 +39.6 39625 2.1 FOXA2 ZFP64 ZNF394 ZNF48 TBX3 ZFHX2 CREB1 ZNF600 HNF4A BCL6 DHX16 PTMAP1 ATAT1 PPP1R10 MRPS18B MDC1 MIR877 ABCF1 C6orf136
GH06G030611 1.7 Ensembl ENCODE dbSUPER 0.7 -1.8 -1768 8.7 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ABCF1 PPP1R10 RPL3P2 NRM TRIM26 MIR877 GTF2H4 C6orf136 DDX39B DHX16
GH06G030602 1.1 dbSUPER 0.4 -13.3 -13320 3.0 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARNT AGO1 ARID4B SIN3A DMAP1 ATAT1 GNL1 PRR3 PTMAP1 C6orf136 ABCF1 ZFP57 HLA-L MRPS18B PIR62319
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPS18B on UCSC Golden Path with GeneCards custom track

Promoters for MRPS18B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000195418 -520 4001 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for MRPS18B Gene

Chromosome:
6
Start:
30,617,320 bp from pter
End:
30,626,397 bp from pter
Size:
9,078 bases
Orientation:
Plus strand

Genomic View for MRPS18B Gene

Genes around MRPS18B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS18B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS18B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MRPS18B Gene

  • Protein details for MRPS18B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y676-RT18B_HUMAN
    Recommended name:
    28S ribosomal protein S18b, mitochondrial
    Protein Accession:
    Q9Y676
    Secondary Accessions:
    • A6NDQ0
    • Q659G4
    • Q9BS27

    Protein attributes for MRPS18B Gene

    Size:
    258 amino acids
    Molecular mass:
    29396 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mS40 has a zinc binding site.
    Miscellaneous:
    • There are 3 mitochondrial isoforms of bS18 in mammalia, localizing to 3 distinct sites in the mitoribosome. bS18m (bs18c) binds to the same site as bacterial bS18, mS40 (bS18b, this protein) binds to a novel location of the 28S small subunit, and mL66 (bS18a) binds to the 39S large subunit.

    Three dimensional structures from OCA and Proteopedia for MRPS18B Gene

neXtProt entry for MRPS18B Gene

Post-translational modifications for MRPS18B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS18B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS18B Gene

Domains & Families for MRPS18B Gene

Gene Families for MRPS18B Gene

Protein Domains for MRPS18B Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9Y676

UniProtKB/Swiss-Prot:

RT18B_HUMAN :
  • Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
Family:
  • Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.
genes like me logo Genes that share domains with MRPS18B: view

Function for MRPS18B Gene

Gene Ontology (GO) - Molecular Function for MRPS18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
genes like me logo Genes that share ontologies with MRPS18B: view

Phenotypes for MRPS18B Gene

genes like me logo Genes that share phenotypes with MRPS18B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS18B Gene

Localization for MRPS18B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS18B Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS18B gene
Compartment Confidence
mitochondrion 5
nucleus 5
peroxisome 2
cytosol 2

Gene Ontology (GO) - Cellular Components for MRPS18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA,IBA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit NAS 11279123
genes like me logo Genes that share ontologies with MRPS18B: view

Pathways & Interactions for MRPS18B Gene

genes like me logo Genes that share pathways with MRPS18B: view

Gene Ontology (GO) - Biological Process for MRPS18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0032543 mitochondrial translation ISS 11402041
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS18B: view

No data available for SIGNOR curated interactions for MRPS18B Gene

Drugs & Compounds for MRPS18B Gene

No Compound Related Data Available

Transcripts for MRPS18B Gene

Unigene Clusters for MRPS18B Gene

Mitochondrial ribosomal protein S18B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS18B Gene

No ASD Table

Relevant External Links for MRPS18B Gene

GeneLoc Exon Structure for
MRPS18B
ECgene alternative splicing isoforms for
MRPS18B

Expression for MRPS18B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS18B Gene

mRNA differential expression in normal tissues according to GTEx for MRPS18B Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for MRPS18B Gene

This gene is overexpressed in Nasal epithelium (20.1), Breast (11.8), and Lavage (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS18B Gene



Protein tissue co-expression partners for MRPS18B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS18B Gene:

MRPS18B

SOURCE GeneReport for Unigene cluster for MRPS18B Gene:

Hs.655329

Evidence on tissue expression from TISSUES for MRPS18B Gene

  • Nervous system(4.7)
  • Heart(4.4)
  • Blood(4.3)
  • Liver(2.5)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with MRPS18B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS18B Gene

Orthologs for MRPS18B Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS18B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS18B 34 35
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia MRPS18B 34 35
  • 86.33 (n)
cow
(Bos Taurus)
Mammalia MRPS18B 34 35
  • 86.18 (n)
mouse
(Mus musculus)
Mammalia Mrps18b 34 16 35
  • 82.02 (n)
rat
(Rattus norvegicus)
Mammalia Mrps18b 34
  • 81.55 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPS18B 35
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPS18B 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489063 34
  • 54.65 (n)
zebrafish
(Danio rerio)
Actinopterygii mrps18b 34 35
  • 53.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpS18b 36
  • 45 (a)
mRpS18B 35
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrps-18B 35
  • 24 (a)
OneToOne
Species where no ortholog for MRPS18B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS18B Gene

ENSEMBL:
Gene Tree for MRPS18B (if available)
TreeFam:
Gene Tree for MRPS18B (if available)

Paralogs for MRPS18B Gene

Pseudogenes.org Pseudogenes for MRPS18B Gene

genes like me logo Genes that share paralogs with MRPS18B: view

No data available for Paralogs for MRPS18B Gene

Variants for MRPS18B Gene

Sequence variations from dbSNP and Humsavar for MRPS18B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000048094 -- 30,626,582(+) GGCCC(C/T)CACTC downstream-variant-500B, upstream-variant-2KB
rs1000442325 -- 30,616,660(+) CAACT(C/T)CATTT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000473154 -- 30,616,508(+) ACCTC(A/G)GGCTC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000655568 -- 30,621,065(+) AAAAG(C/T)CTTCA intron-variant
rs1000967267 -- 30,617,785(+) GGCTT(C/G/T)TCCTT intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPS18B Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv5244 CNV deletion 18451855
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781
nsv830626 CNV loss 17160897

Variation tolerance for MRPS18B Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS18B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS18B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS18B Gene

Disorders for MRPS18B Gene

Relevant External Links for MRPS18B

Genetic Association Database (GAD)
MRPS18B
Human Genome Epidemiology (HuGE) Navigator
MRPS18B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS18B

No disorders were found for MRPS18B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS18B Gene

Publications for MRPS18B Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4 64
  2. Ribosome. The structure of the human mitochondrial ribosome. (PMID: 25838379) Amunts A. … Ramakrishnan V. (Science 2015) 3 4 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  5. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. (PMID: 16702430) Shiina T. … Bahram S. (Genetics 2006) 3 4 64

Products for MRPS18B Gene

Sources for MRPS18B Gene

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