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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRPS18B Gene

protein-coding   GIFtS: 50
GCID: GC06P030585

mitochondrial ribosomal protein S18B

 Explore 2 diseases affiliated with
MRPS18B via our new
 Human Malady Compendium 
Biological research products
for MRPS18B
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mitochondrial Ribosomal Protein S18B1 2     S18mt-B1
C6orf141 2 3     28S Ribosomal Protein S18b, Mitochondrial2
MRPS18-21 2 5     HumanS18a2
HSPC1831 2     S18amt2
PTD0171 2     Mitochondrial Ribosomal Protein S18-22
28S Ribosomal Protein S18-2, Mitochondrial2 3     Mrps18-B1
MRP-S18-22 3     Mrps18-B1
MRP-S18-B1     

External Ids:    HGNC: 145161   Entrez Gene: 289732   Ensembl: ENSG000002045687   OMIM: 6119825   UniProtKB: Q9Y6763   

Export aliases for MRPS18B gene to outside databases

Previous GC identifers: GC06P030641 GC06P030356 GC06P030691 GC06P030693 GC06P030386


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRPS18B:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They
have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.
Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.
Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in
biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein
that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence
similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more
closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene
are found on chromosomes 1q and 2q. (provided by RefSeq, Jul 2008)

Gene Wiki entry for MRPS18B


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  NT_113891.2  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRPS18B gene promoter:
         MAZR   MEF-2   Egr-2   CREB   MEF-2A   PPAR-gamma1   deltaCREB   HOXA5   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPS18B promoter sequence
   Search SABiosciences Chromatin IP Primers for MRPS18B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS18B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.33   HGNC cytogenetic band: 6p21

MRPS18B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPS18B gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P030585:  view genomic region     (about GC identifiers)

Start:
30,585,486 bp from pter      End:
30,594,174 bp from pter
Size:
8,689 bases      Orientation:
plus strand

6 alternative locations:
Chr6+,ALT_REF_LOCI_4 30,553,217-30,561,905      Chr6+,ALT_REF_LOCI_5 30,578,765-30,587,453      Chr6+,ALT_REF_LOCI_6 30,574,996-30,619,265     
Chr6+,ALT_REF_LOCI_3 30,575,727-30,595,453      Chr6+,ALT_REF_LOCI_2 30,575,335-30,623,211      Chr6+,ALT_REF_LOCI_7 30,507,230-30,515,918     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RT18B_HUMAN, Q9Y676 (See protein sequence)
Recommended Name: 28S ribosomal protein S18b, mitochondrial precursor  
Size: 258 amino acids; 29396 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct
proteins
Subcellular location: Mitochondrion
Secondary accessions: A6NDQ0 Q659G4 Q9BS27

Explore the universe of human proteins at neXtProt for MRPS18B: NX_Q9Y676

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y676

  • MRPS18B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_054765.1  
    ENSEMBL proteins: 
     ENSP00000259873   ENSP00000365691   ENSP00000445207  

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    Uscn Proteins for MRPS18B

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005763mitochondrial small ribosomal subunit NAS11279123
    GO:0005840ribosome ----


    MRPS18B for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for MRPS18B


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MRPS18B for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001648 Ribosomal_S18

    Graphical View of Domain Structure for InterPro Entry Q9Y676

    ProtoNet protein and cluster: Q9Y676

    1 Blocks protein family: IPB001648 Ribosomal protein S18

    UniProtKB/Swiss-Prot: RT18B_HUMAN, Q9Y676
    Similarity: Belongs to the ribosomal protein S18P family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRPS18B
    1 QIAGEN miScript miRNA Assays for microRNA that regulate MRPS18B:
    hsa-miR-588
    SwitchGear 3'UTR luciferase reporter plasmidMRPS18B 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPS18B (see all 7)
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS11279123


    MRPS18B for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MRPS18B:
     Proliferating cells 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS18B

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/238 Interacting proteins for MRPS18B (Q9Y6761, 2, 3 ENSP000002598734) via UniProtKB, MINT, STRING, and/or I2D (see all 238)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKBIL1Q9UBC11, 3EBI-750085,EBI-1043728 I2D: score=2 
    ICT1Q141972, 3MINT-8079030 I2D: score=1 
    EWSR1Q018443, ENSP000003810314I2D: score=4 STRING: ENSP00000381031
    RTFDC1Q9BY423I2D: score=5 
    UBCP0CG483I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation NAS11279123


    MRPS18B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRPS18B
    Search CenterWatch for drugs/clinical trials and news about MRPS18B / RT18B 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRPS18B gene: 
    NM_014046.3  

    Unigene Cluster for MRPS18B:

    Mitochondrial ribosomal protein S18B
    Hs.655329  [show with all ESTs]
    Unigene Representative Sequence: AK126124
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000259873(uc003nqo.2 uc011dml.1) ENST00000492316 ENST00000472267
    ENST00000376508 ENST00000472229 ENST00000506373

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate MRPS18B:
    hsa-miR-588
    SwitchGear 3'UTR luciferase reporter plasmidMRPS18B 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPS18B (see all 7)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS18B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS18B

    Additional cDNA sequence: 

    AF100761.1 AF151017.1 AK126124.1 AK294086.1 AK311890.1 AL050361.1 BC005373.1 

    20 DOTS entries:

    DT.121360437  DT.100828350  DT.121360160  DT.100828351  DT.448717  DT.95176499  DT.100834267  DT.100828356 
    DT.92452199  DT.121360348  DT.40264713  DT.100828348  DT.100034656  DT.40132910  DT.95176496  DT.100037687 
    DT.100698545  DT.121438442  DT.40209927  DT.95343195 

    24/397 AceView cDNA sequences (see all 397):

    BF439961 AA353989 CB125952 BU153090 BM479084 BF726230 BX381098 AA359404 
    BQ006444 BQ233190 BM831556 NM_014046 CB110642 BU195592 CA952775 AA329181 
    BQ939692 AA315580 CB143256 BU506800 Z45454 AI246471 AI291321 BX104934 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRPS18B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTACAACTGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MRPS18B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRPS18B

    SOURCE GeneReport for Unigene cluster: Hs.655329
        SABiosciences Expression via Pathway-Focused PCR Arrays including MRPS18B: 
              Hepatotoxicity in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS18B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MRPS18B gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrps18b1 , 5 mitochondrial ribosomal protein S18B1, 5 82.02(n)1
    78.74(a)1
      17 (18.76 cM)5
    669731  NM_025878.11  NP_080154.11 
     359103795 
    lizard
    (Anolis carolinensis)
    Reptilia MRPS18B6
    --
    54(a)
    1 ↔ 1
    2(192052143-192059130)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW642253.12   -- 69.79(n)    AW642253.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mrps18b1 mitochondrial ribosomal protein S18B 53.21(n)
    48.83(a)
      550455  NM_001017759.1  NP_001017759.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpS18b3 protein biosynthesis structural constituent
    of more
    45(a)   38B6   --
    worm
    (Caenorhabditis elegans)
    Secernentea mrps-18B6
    Protein MRPS-18B
    21(a)
    1 ↔ 1
    II(8525634-8526755)


    ENSEMBL Gene Tree for MRPS18B (if available)
    TreeFam Gene Tree for MRPS18B (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRPS18B gene

    MRPS18B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MRPS18B
    PGOHUM00000240966


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/160 NCBI SNPs in MRPS18B are shown (see all 160    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1842852671,2
    --30587144(+) CTTACA/GTATGC 1 -- int10--------
    rs1468967251,2
    --30587226(+) TAGTCC/TTTTCC 1 -- int10--------
    rs351152481,2
    C,F--30587326(+) TCCTCA/GGTTCC 2 S syn13Minor allele frequency- G:0.33NA 6
    rs1495041701,2
    C,F--30587354(+) ATGAGC/TCCTGG 2 P S mis11Minor allele frequency- T:0.00NA 4496
    rs1141480051,2
    F,--30587406(+) AGGGTC/GAGATA 1 -- int11Minor allele frequency- G:0.02NA 120
    rs1472012681,2
    F--30587502(+) CGATAT/CGGTTC 2 /Y syn11Minor allele frequency- C:0.00NA 4540
    rs1888207941,2
    --30587514(+) CGCCCC/TGTCTG 2 P syn10--------
    rs1474835971,2
    C--30587530(+) ACTACC/TGCCGC 2 R C mis11Minor allele frequency- T:0.00NA 4542
    rs1130793481,2
    C,--30587564(+) ACAGCG/AGACTC 2 /Q /R mis12Minor allele frequency- A:0.01CSA WA 218
    rs1419467411,2
    --30587598(+) TGAGAA/GTGGGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for MRPS18B (30585486 - 30594174 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MRPS18B: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS18B
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPS18B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MRPS18B for disorders           About GeneDecksing

    OMIM gene information: 611982    OMIM disorders: --

    2 diseases for MRPS18B:    About MalaCards
    systemic lupus erythematosus    lupus erythematosus

    Human Genome Epidemiology (HuGE) Navigator: MRPS18B (2 documents)

    Export disorders for MRPS18B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRPS18B gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with MRPS18B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2, 3 Koc E.C.... Spremulli L.L. (2001)
    2. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. (PubMed id 16702430)1, 2 Shiina T.... Bahram S. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
    9. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
    10. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 28973 HGNC: 14516 AceView: MRPS18B Ensembl:ENSG00000204568 euGenes: HUgn28973
    ECgene: MRPS18B H-InvDB: MRPS18B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRPS18B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRPS18B gene:
    Search GeneIP for patents involving MRPS18B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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