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Aliases for MRPS18B Gene

Aliases for MRPS18B Gene

  • Mitochondrial Ribosomal Protein S18B 2 3 5
  • 28S Ribosomal Protein S18-2, Mitochondrial 3 4
  • MRP-S18-2 3 4
  • MRP-S18-B 3 4
  • Mrps18-B 3 4
  • C6orf14 3 4
  • S18mt-B 3 4
  • 28S Ribosomal Protein S18b, Mitochondrial 3
  • Mitochondrial Ribosomal Protein S18-2 3
  • HumanS18a 3
  • MRPS18-2 3
  • HSPC183 3
  • PTD017 3
  • S18amt 3

External Ids for MRPS18B Gene

Previous GeneCards Identifiers for MRPS18B Gene

  • GC06P030641
  • GC06P030356
  • GC06P030691
  • GC06P030693
  • GC06P030585
  • GC06P030386

Summaries for MRPS18B Gene

Entrez Gene Summary for MRPS18B Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS18B Gene

MRPS18B (Mitochondrial Ribosomal Protein S18B) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS18B Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS18B Gene

Genomics for MRPS18B Gene

Regulatory Elements for MRPS18B Gene

Enhancers for MRPS18B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F030541 1.3 Ensembl ENCODE 11.5 -74.3 -74288 3.9 HDGF PKNOX1 WRNIP1 ARID4B SIN3A ZNF48 ZNF2 YY1 ZNF121 ZNF766 ABCF1 ENSG00000235781 MIR877 MRPS18B PPP1R10 ATAT1 PTMAP1 C6orf136 HLA-C HCG4
GH06F030735 1.1 Ensembl ENCODE 12 +119.8 119790 2.9 HDGF TBP PKNOX1 WRNIP1 BMI1 ZBTB40 ZNF366 GATA2 ELK1 ZNF143 PTMAP1 ATAT1 PPP1R10 MRPS18B PSORS1C2 MDC1-AS1 C6orf136 DHX16 VARS2 TRIM31
GH06F030655 0.6 ENCODE 12.2 +39.6 39625 2.1 ZFHX2 ZFP64 CREB1 ZNF600 BCL6 ZNF48 EGR2 DHX16 PTMAP1 ATAT1 MRPS18B PPP1R10 MDC1 MIR877 ABCF1 C6orf136
GH06F030611 1.2 ENCODE 0.8 -1.7 -1727 8.6 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ABCF1 PPP1R10 DHX16 DDX39B GTF2H4 HCG18 RPL7P4 TMPOP1 UBQLN1P1 ENSG00000233902
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPS18B on UCSC Golden Path with GeneCards custom track

Promoters for MRPS18B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001494504 -720 4801 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC

Genomic Location for MRPS18B Gene

30,617,320 bp from pter
30,626,397 bp from pter
9,078 bases
Plus strand

Genomic View for MRPS18B Gene

Genes around MRPS18B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS18B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS18B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for MRPS18B Gene

  • Protein details for MRPS18B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S18b, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A6NDQ0
    • Q659G4
    • Q9BS27

    Protein attributes for MRPS18B Gene

    258 amino acids
    Molecular mass:
    29396 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS18B Gene

neXtProt entry for MRPS18B Gene

Post-translational modifications for MRPS18B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS18B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS18B Gene

Domains & Families for MRPS18B Gene

Gene Families for MRPS18B Gene

Protein Domains for MRPS18B Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S18P family.
  • Belongs to the ribosomal protein S18P family.
genes like me logo Genes that share domains with MRPS18B: view

Function for MRPS18B Gene

Gene Ontology (GO) - Molecular Function for MRPS18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
genes like me logo Genes that share ontologies with MRPS18B: view

Phenotypes for MRPS18B Gene

genes like me logo Genes that share phenotypes with MRPS18B: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS18B Gene

Localization for MRPS18B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS18B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS18B gene
Compartment Confidence
mitochondrion 5
nucleus 5
peroxisome 2
cytosol 2

Gene Ontology (GO) - Cellular Components for MRPS18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA,IBA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit NAS 11279123
genes like me logo Genes that share ontologies with MRPS18B: view

Pathways & Interactions for MRPS18B Gene

genes like me logo Genes that share pathways with MRPS18B: view

Interacting Proteins for MRPS18B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9Y676-RT18B_HUMAN ENSP00000259873 for MRPS18B Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for MRPS18B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0032543 mitochondrial translation ISS 11402041
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS18B: view

No data available for SIGNOR curated interactions for MRPS18B Gene

Transcripts for MRPS18B Gene

Unigene Clusters for MRPS18B Gene

Mitochondrial ribosomal protein S18B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS18B Gene

No ASD Table

Relevant External Links for MRPS18B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS18B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPS18B Gene

mRNA differential expression in normal tissues according to GTEx for MRPS18B Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for MRPS18B Gene

This gene is overexpressed in Nasal epithelium (20.1), Breast (11.8), and Lavage (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS18B Gene

Protein tissue co-expression partners for MRPS18B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS18B Gene:


SOURCE GeneReport for Unigene cluster for MRPS18B Gene:

genes like me logo Genes that share expression patterns with MRPS18B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MRPS18B Gene

Orthologs for MRPS18B Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS18B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPS18B 34 35
  • 99.74 (n)
(Canis familiaris)
Mammalia MRPS18B 34 35
  • 86.33 (n)
(Bos Taurus)
Mammalia MRPS18B 34 35
  • 86.18 (n)
(Mus musculus)
Mammalia Mrps18b 34 16 35
  • 82.02 (n)
(Rattus norvegicus)
Mammalia Mrps18b 34
  • 81.55 (n)
(Monodelphis domestica)
Mammalia MRPS18B 35
  • 73 (a)
(Anolis carolinensis)
Reptilia MRPS18B 35
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489063 34
  • 54.65 (n)
(Danio rerio)
Actinopterygii mrps18b 34 35
  • 53.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpS18b 36
  • 45 (a)
mRpS18B 35
  • 36 (a)
(Caenorhabditis elegans)
Secernentea mrps-18B 35
  • 24 (a)
Species where no ortholog for MRPS18B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS18B Gene

Gene Tree for MRPS18B (if available)
Gene Tree for MRPS18B (if available)

Paralogs for MRPS18B Gene Pseudogenes for MRPS18B Gene

genes like me logo Genes that share paralogs with MRPS18B: view

No data available for Paralogs for MRPS18B Gene

Variants for MRPS18B Gene

Sequence variations from dbSNP and Humsavar for MRPS18B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1052875 -- 30,616,583(-) CCCTA(A/T)ATAAT nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs111296996 -- 30,621,609(+) GTCCC(A/G)TAGAT intron-variant
rs111609724 -- 30,626,392(+) CTGGT(A/T)TGCTT upstream-variant-2KB, utr-variant-3-prime
rs111850078 -- 30,626,325(+) GGCTA(A/G)ACATT upstream-variant-2KB, utr-variant-3-prime
rs112418429 -- 30,626,350(+) CTTCT(A/G)CCAAC upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPS18B Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv5244 CNV deletion 18451855
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781
nsv830626 CNV loss 17160897

Variation tolerance for MRPS18B Gene

Residual Variation Intolerance Score: 77.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.15; 61.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS18B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS18B Gene

Disorders for MRPS18B Gene

Relevant External Links for MRPS18B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPS18B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS18B Gene

Publications for MRPS18B Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  4. Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. (PMID: 16702430) Shiina T. … Bahram S. (Genetics 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MRPS18B Gene

Sources for MRPS18B Gene

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