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Aliases for MRPS18A Gene

Aliases for MRPS18A Gene

  • Mitochondrial Ribosomal Protein S18A 2 3
  • 28S Ribosomal Protein S18-3, Mitochondrial 3 4
  • MRP-S18-3 3 4
  • MRP-S18-A 3 4
  • MRPS18-3 3 6
  • S18mt-A 3 4
  • 28S Ribosomal Protein S18a, Mitochondrial 3
  • Mitochondrial Ribosomal Protein S18-3 3
  • HumanS18b 3
  • Mrps18a 4
  • S18bmt 3

External Ids for MRPS18A Gene

Previous GeneCards Identifiers for MRPS18A Gene

  • GC06M043641
  • GC06M043685
  • GC06M043747
  • GC06M043357

Summaries for MRPS18A Gene

Entrez Gene Summary for MRPS18A Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this gene is found on chromosome 3p. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]

GeneCards Summary for MRPS18A Gene

MRPS18A (Mitochondrial Ribosomal Protein S18A) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS18A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS18A Gene

Genomics for MRPS18A Gene

Regulatory Elements for MRPS18A Gene

Genomic Location for MRPS18A Gene

43,671,197 bp from pter
43,687,812 bp from pter
16,616 bases
Minus strand

Genomic View for MRPS18A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS18A Gene

Proteins for MRPS18A Gene

  • Protein details for MRPS18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S18a, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A6XND3
    • Q5QPA4

    Protein attributes for MRPS18A Gene

    196 amino acids
    Molecular mass:
    22184 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins

    Three dimensional structures from OCA and Proteopedia for MRPS18A Gene

    Alternative splice isoforms for MRPS18A Gene


neXtProt entry for MRPS18A Gene

Proteomics data for MRPS18A Gene at MOPED

Post-translational modifications for MRPS18A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS18A Gene

Antibody Products

No data available for DME Specific Peptides for MRPS18A Gene

Domains for MRPS18A Gene

Gene Families for MRPS18A Gene

  • MRPS :Mitochondrial ribosomal proteins / small subunits

Protein Domains for MRPS18A Gene


Suggested Antigen Peptide Sequences for MRPS18A Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9NVS2
  • Belongs to the ribosomal protein S18P family.
genes like me logo Genes that share domains with MRPS18A: view

Function for MRPS18A Gene

Gene Ontology (GO) - Molecular Function for MRPS18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
genes like me logo Genes that share ontologies with MRPS18A: view

Animal Model Products

miRNA for MRPS18A Gene

miRTarBase miRNAs that target MRPS18A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS18A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPS18A Gene

Localization for MRPS18A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS18A Gene


Subcellular locations from

Jensen Localization Image for MRPS18A Gene COMPARTMENTS Subcellular localization image for MRPS18A gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MRPS18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IDA 11279123
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with MRPS18A: view

Pathways for MRPS18A Gene

SuperPathways for MRPS18A Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
genes like me logo Genes that share pathways with MRPS18A: view

Pathways by source for MRPS18A Gene

1 KEGG pathway for MRPS18A Gene

Gene Ontology (GO) - Biological Process for MRPS18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPS18A: view

Transcripts for MRPS18A Gene

Unigene Clusters for MRPS18A Gene

Mitochondrial ribosomal protein S18A:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS18A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS18A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3: - - -

Relevant External Links for MRPS18A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS18A Gene

mRNA expression in normal human tissues for MRPS18A Gene

mRNA differential expression in normal tissues according to GTEx for MRPS18A Gene

This gene is overexpressed in Muscle - Skeletal (4.3).

Protein differential expression in normal tissues for MRPS18A Gene

This gene is overexpressed in Lung (34.5) and Breast (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS18A Gene

SOURCE GeneReport for Unigene cluster for MRPS18A Gene Hs.520149

genes like me logo Genes that share expressions with MRPS18A: view

Expression partners for MRPS18A Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MRPS18A Gene

Orthologs for MRPS18A Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS18A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS18A 35
  • 85.88 (n)
  • 83.67 (a)
MRPS18A 36
  • 84 (a)
(Canis familiaris)
Mammalia MRPS18A 35
  • 86.05 (n)
  • 83.16 (a)
MRPS18A 36
  • 83 (a)
(Mus musculus)
Mammalia Mrps18a 35
  • 82.99 (n)
  • 81.12 (a)
Mrps18a 16
Mrps18a 36
  • 81 (a)
(Pan troglodytes)
Mammalia MRPS18A 35
  • 99.83 (n)
  • 99.49 (a)
MRPS18A 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mrps18a 35
  • 81.8 (n)
  • 81.12 (a)
(Monodelphis domestica)
Mammalia MRPS18A 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS18A 36
  • 82 (a)
(Gallus gallus)
Aves MRPS18A 35
  • 67.41 (n)
  • 68.33 (a)
MRPS18A 36
  • 67 (a)
(Anolis carolinensis)
Reptilia MRPS18A 36
  • 64 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13203 35
(Danio rerio)
Actinopterygii Dr.14790 35
mrps18a 35
  • 63.64 (n)
  • 66.67 (a)
mrps18a 36
  • 55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10606 35
fruit fly
(Drosophila melanogaster)
Insecta mRpS18A 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea mrps-18A 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3245 36
  • 31 (a)
Species with no ortholog for MRPS18A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MRPS18A Gene

Gene Tree for MRPS18A (if available)
Gene Tree for MRPS18A (if available)

Paralogs for MRPS18A Gene Pseudogenes for MRPS18A Gene

genes like me logo Genes that share paralogs with MRPS18A: view

No data available for Paralogs for MRPS18A Gene

Variants for MRPS18A Gene

Sequence variations from dbSNP and Humsavar for MRPS18A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs833048 -- 43,686,799(+) AGGAA(C/G)GCTAT intron-variant
rs1334600 -- 43,681,784(+) AAGTA(C/T)TGCCA intron-variant
rs1334601 -- 43,685,668(+) GATGC(C/T)TGAAT intron-variant
rs1334602 -- 43,685,826(+) AAAAG(A/G)AAATG intron-variant
rs2236345 -- 43,681,066(+) TATAC(A/G)TGGCC intron-variant

Relevant External Links for MRPS18A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPS18A Gene

Disorders for MRPS18A Gene

Relevant External Links for MRPS18A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MRPS18A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MRPS18A Gene

Publications for MRPS18A Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4
  2. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PMID: 11402041) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4
  3. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for MRPS18A Gene

Sources for MRPS18A Gene

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