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Aliases for MRPS18A Gene

Aliases for MRPS18A Gene

  • Mitochondrial Ribosomal Protein S18A 2 3 5
  • 28S Ribosomal Protein S18-3, Mitochondrial 3 4
  • MRP-S18-3 3 4
  • MRP-S18-A 3 4
  • S18mt-A 3 4
  • 28S Ribosomal Protein S18a, Mitochondrial 3
  • Mitochondrial Ribosomal Protein S18-3 3
  • HumanS18b 3
  • MRPS18-3 3
  • Mrps18a 4
  • S18bmt 3

External Ids for MRPS18A Gene

Previous GeneCards Identifiers for MRPS18A Gene

  • GC06M043641
  • GC06M043685
  • GC06M043747
  • GC06M043357

Summaries for MRPS18A Gene

Entrez Gene Summary for MRPS18A Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this gene is found on chromosome 3p. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]

GeneCards Summary for MRPS18A Gene

MRPS18A (Mitochondrial Ribosomal Protein S18A) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS18A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS18A Gene

Genomics for MRPS18A Gene

Regulatory Elements for MRPS18A Gene

Enhancers for MRPS18A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F043723 1.7 FANTOM5 Ensembl ENCODE 11.6 -37.1 -37089 3.0 HDGF ARNT CREB3L1 MLX ARID4B FEZF1 DMAP1 ZNF2 SLC30A9 ZNF143 POLH ENSG00000271970 MAD2L1BP VEGFA GLTSCR1L MRPS18A RSPH9 GTPBP2 RPL24P4 CAPN11
GH06F043713 1.3 Ensembl ENCODE 11.7 -27.8 -27800 3.7 HDGF ATF1 WRNIP1 ARID4B ZNF48 ZNF121 GATA2 YY2 JUNB MXD4 ENSG00000223469 RPS2P28 RPL29P16 MRPS18A RSPH9 MAD2L1BP GTPBP2 NFKBIE MIR4647 SLC35B2
GH06F043717 0.4 ENCODE 11.2 -30.1 -30107 0.2 ZFHX2 EGR2 MRPS18A MIR4647 SLC35B2 NFKBIE LOC100132242 LOC105375066
GH06F043910 1.8 FANTOM5 Ensembl ENCODE 1.4 -226.7 -226661 8.4 HDGF PKNOX1 ARNT MLX CREB3L1 ARID4B DMAP1 ZNF2 YY1 SLC30A9 AARS2 CUL9 ENSG00000271970 RPL24P4 RPS2P29 GTPBP2 MRPS18A LOC105375067 GC06M043993
GH06F043686 1.1 ENCODE 0.8 +0.1 90 1.8 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS SP3 LOC101929726 RSPH9 GTPBP2 MAD2L1BP MRPS18A GC06M043677
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPS18A on UCSC Golden Path with GeneCards custom track

Promoters for MRPS18A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001880864 12 1600 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 FOS SP3 SP5

Genomic Location for MRPS18A Gene

Chromosome:
6
Start:
43,671,197 bp from pter
End:
43,687,812 bp from pter
Size:
16,616 bases
Orientation:
Minus strand

Genomic View for MRPS18A Gene

Genes around MRPS18A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS18A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS18A Gene

Proteins for MRPS18A Gene

  • Protein details for MRPS18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVS2-RT18A_HUMAN
    Recommended name:
    28S ribosomal protein S18a, mitochondrial
    Protein Accession:
    Q9NVS2
    Secondary Accessions:
    • A6XND3
    • Q5QPA4

    Protein attributes for MRPS18A Gene

    Size:
    196 amino acids
    Molecular mass:
    22184 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS18A Gene

    Alternative splice isoforms for MRPS18A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPS18A Gene

Post-translational modifications for MRPS18A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS18A Gene

No data available for DME Specific Peptides for MRPS18A Gene

Domains & Families for MRPS18A Gene

Gene Families for MRPS18A Gene

Protein Domains for MRPS18A Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPS18A Gene

Graphical View of Domain Structure for InterPro Entry

Q9NVS2

UniProtKB/Swiss-Prot:

RT18A_HUMAN :
  • Belongs to the ribosomal protein S18P family.
Family:
  • Belongs to the ribosomal protein S18P family.
genes like me logo Genes that share domains with MRPS18A: view

Function for MRPS18A Gene

Gene Ontology (GO) - Molecular Function for MRPS18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
genes like me logo Genes that share ontologies with MRPS18A: view

Phenotypes for MRPS18A Gene

GenomeRNAi human phenotypes for MRPS18A:
genes like me logo Genes that share phenotypes with MRPS18A: view

Animal Model Products

miRNA for MRPS18A Gene

miRTarBase miRNAs that target MRPS18A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS18A Gene

Localization for MRPS18A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS18A Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS18A gene
Compartment Confidence
mitochondrion 5
cytosol 4
extracellular 1

Gene Ontology (GO) - Cellular Components for MRPS18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IDA 11279123
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS18A: view

Pathways & Interactions for MRPS18A Gene

genes like me logo Genes that share pathways with MRPS18A: view

Interacting Proteins for MRPS18A Gene

Gene Ontology (GO) - Biological Process for MRPS18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,NAS 11279123
GO:0032543 mitochondrial translation ISS 11402041
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS18A: view

No data available for SIGNOR curated interactions for MRPS18A Gene

Transcripts for MRPS18A Gene

Unigene Clusters for MRPS18A Gene

Mitochondrial ribosomal protein S18A:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS18A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for MRPS18A Gene

GeneLoc Exon Structure for
MRPS18A
ECgene alternative splicing isoforms for
MRPS18A

Expression for MRPS18A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPS18A Gene

mRNA differential expression in normal tissues according to GTEx for MRPS18A Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for MRPS18A Gene

This gene is overexpressed in Lung (34.5) and Breast (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS18A Gene



Protein tissue co-expression partners for MRPS18A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS18A Gene:

MRPS18A

SOURCE GeneReport for Unigene cluster for MRPS18A Gene:

Hs.520149
genes like me logo Genes that share expression patterns with MRPS18A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MRPS18A Gene

Orthologs for MRPS18A Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS18A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS18A 34 35
  • 99.83 (n)
dog
(Canis familiaris)
Mammalia MRPS18A 34 35
  • 86.05 (n)
cow
(Bos Taurus)
Mammalia MRPS18A 34 35
  • 85.88 (n)
mouse
(Mus musculus)
Mammalia Mrps18a 34 16 35
  • 82.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS18A 35
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps18a 34
  • 81.8 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPS18A 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS18A 34 35
  • 67.41 (n)
lizard
(Anolis carolinensis)
Reptilia MRPS18A 35
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13203 34
zebrafish
(Danio rerio)
Actinopterygii mrps18a 34 35
  • 63.64 (n)
Dr.14790 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10606 34
fruit fly
(Drosophila melanogaster)
Insecta mRpS18A 35
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrps-18A 35
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3245 35
  • 31 (a)
OneToOne
Species where no ortholog for MRPS18A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MRPS18A Gene

ENSEMBL:
Gene Tree for MRPS18A (if available)
TreeFam:
Gene Tree for MRPS18A (if available)

Paralogs for MRPS18A Gene

Pseudogenes.org Pseudogenes for MRPS18A Gene

genes like me logo Genes that share paralogs with MRPS18A: view

No data available for Paralogs for MRPS18A Gene

Variants for MRPS18A Gene

Sequence variations from dbSNP and Humsavar for MRPS18A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs397515340 Pathogenic 43,670,919(+) GGCGA(-/GAA)GAACA downstream-variant-500B, cds-indel
rs397518457 Pathogenic 43,670,922(+) GAGAA(-/GAA)CATGG downstream-variant-500B, cds-indel
rs757687268 Likely benign 43,670,820(+) GGCAA(A/C/T)GCCCT nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon, missense
rs770913202 Uncertain significance 43,670,916(+) ACTGG(C/T)GAGAA downstream-variant-500B, reference, synonymous-codon, stop-gained
rs16896629 Benign 43,670,899(+) GCTAC(A/G)TCTAC downstream-variant-500B, reference, missense

Variation tolerance for MRPS18A Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS18A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS18A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPS18A Gene

Disorders for MRPS18A Gene

Relevant External Links for MRPS18A

Genetic Association Database (GAD)
MRPS18A
Human Genome Epidemiology (HuGE) Navigator
MRPS18A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS18A

No disorders were found for MRPS18A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS18A Gene

Publications for MRPS18A Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for MRPS18A Gene

Sources for MRPS18A Gene

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