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Aliases for MRPS18A Gene

Aliases for MRPS18A Gene

  • Mitochondrial Ribosomal Protein S18A 2 3 5
  • 28S Ribosomal Protein S18-3, Mitochondrial 3 4
  • MRP-S18-3 3 4
  • MRP-S18-A 3 4
  • S18mt-A 3 4
  • Mitochondrial Ribosomal Protein S18-3 3
  • HumanS18b 3
  • MRPS18-3 3
  • Mrps18a 4
  • S18bmt 3

External Ids for MRPS18A Gene

Previous GeneCards Identifiers for MRPS18A Gene

  • GC06M043641
  • GC06M043685
  • GC06M043747
  • GC06M043357

Summaries for MRPS18A Gene

Entrez Gene Summary for MRPS18A Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this gene is found on chromosome 3p. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]

GeneCards Summary for MRPS18A Gene

MRPS18A (Mitochondrial Ribosomal Protein S18A) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS18A Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS18A Gene

Genomics for MRPS18A Gene

Regulatory Elements for MRPS18A Gene

Enhancers for MRPS18A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPS18A on UCSC Golden Path with GeneCards custom track

Promoters for MRPS18A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPS18A on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPS18A Gene

43,671,197 bp from pter
43,687,812 bp from pter
16,616 bases
Minus strand

Genomic View for MRPS18A Gene

Genes around MRPS18A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS18A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS18A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS18A Gene

Proteins for MRPS18A Gene

  • Protein details for MRPS18A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S18a, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A6XND3
    • Q5QPA4

    Protein attributes for MRPS18A Gene

    196 amino acids
    Molecular mass:
    22184 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS18A Gene

    Alternative splice isoforms for MRPS18A Gene


neXtProt entry for MRPS18A Gene

Proteomics data for MRPS18A Gene at MOPED

Post-translational modifications for MRPS18A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS18A Gene

No data available for DME Specific Peptides for MRPS18A Gene

Domains & Families for MRPS18A Gene

Gene Families for MRPS18A Gene

Protein Domains for MRPS18A Gene


Suggested Antigen Peptide Sequences for MRPS18A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S18P family.
  • Belongs to the ribosomal protein S18P family.
genes like me logo Genes that share domains with MRPS18A: view

Function for MRPS18A Gene

Phenotypes for MRPS18A Gene

GenomeRNAi human phenotypes for MRPS18A:
genes like me logo Genes that share phenotypes with MRPS18A: view

Animal Model Products

miRNA for MRPS18A Gene

miRTarBase miRNAs that target MRPS18A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS18A Gene

Localization for MRPS18A Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS18A Gene


Subcellular locations from

Jensen Localization Image for MRPS18A Gene COMPARTMENTS Subcellular localization image for MRPS18A gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MRPS18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPS18A: view

Pathways & Interactions for MRPS18A Gene

genes like me logo Genes that share pathways with MRPS18A: view

Gene Ontology (GO) - Biological Process for MRPS18A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,NAS 11279123
GO:0070124 mitochondrial translational initiation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS18A: view

No data available for SIGNOR curated interactions for MRPS18A Gene

Drugs & Compounds for MRPS18A Gene

No Compound Related Data Available

Transcripts for MRPS18A Gene

Unigene Clusters for MRPS18A Gene

Mitochondrial ribosomal protein S18A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS18A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: -
SP3: - - -

Relevant External Links for MRPS18A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS18A Gene

mRNA expression in normal human tissues for MRPS18A Gene

mRNA differential expression in normal tissues according to GTEx for MRPS18A Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

Protein differential expression in normal tissues from HIPED for MRPS18A Gene

This gene is overexpressed in Lung (34.5) and Breast (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS18A Gene

SOURCE GeneReport for Unigene cluster for MRPS18A Gene Hs.520149

genes like me logo Genes that share expression patterns with MRPS18A: view

Protein tissue co-expression partners for MRPS18A Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MRPS18A Gene

Orthologs for MRPS18A Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS18A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS18A 35
  • 85.88 (n)
  • 83.67 (a)
MRPS18A 36
  • 84 (a)
(Canis familiaris)
Mammalia MRPS18A 35
  • 86.05 (n)
  • 83.16 (a)
MRPS18A 36
  • 83 (a)
(Mus musculus)
Mammalia Mrps18a 35
  • 82.99 (n)
  • 81.12 (a)
Mrps18a 16
Mrps18a 36
  • 81 (a)
(Pan troglodytes)
Mammalia MRPS18A 35
  • 99.83 (n)
  • 99.49 (a)
MRPS18A 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mrps18a 35
  • 81.8 (n)
  • 81.12 (a)
(Monodelphis domestica)
Mammalia MRPS18A 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS18A 36
  • 82 (a)
(Gallus gallus)
Aves MRPS18A 35
  • 67.41 (n)
  • 68.33 (a)
MRPS18A 36
  • 67 (a)
(Anolis carolinensis)
Reptilia MRPS18A 36
  • 64 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13203 35
(Danio rerio)
Actinopterygii Dr.14790 35
mrps18a 35
  • 63.64 (n)
  • 66.67 (a)
mrps18a 36
  • 55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10606 35
fruit fly
(Drosophila melanogaster)
Insecta mRpS18A 36
  • 35 (a)
(Caenorhabditis elegans)
Secernentea mrps-18A 36
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3245 36
  • 31 (a)
Species with no ortholog for MRPS18A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MRPS18A Gene

Gene Tree for MRPS18A (if available)
Gene Tree for MRPS18A (if available)

Paralogs for MRPS18A Gene Pseudogenes for MRPS18A Gene

genes like me logo Genes that share paralogs with MRPS18A: view

No data available for Paralogs for MRPS18A Gene

Variants for MRPS18A Gene

Sequence variations from dbSNP and Humsavar for MRPS18A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1334600 -- 43,681,784(+) AAGTA(C/T)TGCCA intron-variant
rs1334601 -- 43,685,668(+) GATGC(C/T)TGAAT intron-variant
rs1334602 -- 43,685,826(+) AAAAG(A/G)AAATG intron-variant
rs11751095 -- 43,673,110(+) agcct(C/T)tggag intron-variant
rs2236345 -- 43,681,066(+) TATAC(A/G)TGGCC intron-variant

Variation tolerance for MRPS18A Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MRPS18A Gene

Disorders for MRPS18A Gene

Relevant External Links for MRPS18A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPS18A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS18A Gene

Publications for MRPS18A Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4 67
  2. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3
  3. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  4. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for MRPS18A Gene

Sources for MRPS18A Gene