MRPS18A Gene
protein-coding GIFtS: 47
GCID: GC06M043639
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|
mitochondrial ribosomal protein S18A
| |
Aliases for MRPS18A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein S18A1 2 | | FLJ105481 | | MRPS18-31 2 5 | | 28S Ribosomal Protein S18a, Mitochondrial2 | | 28S Ribosomal Protein S18-3, Mitochondrial2 3 | | HumanS18b2 | | MRP-S18-32 3 | | S18bmt2 | | MRP-S18-A1 | | Mitochondrial Ribosomal Protein S18-32 | | S18mt-A1 | | Mrps18a3 |
Export aliases for MRPS18A gene to outside databasesPrevious GC identifers: GC06M043641 GC06M043685 GC06M043747 GC06M043357 |
Summaries for MRPS18A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for MRPS18A: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit proteinthat belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequencesimilarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no moreclosely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this geneis found on chromosome 3p. Alternative splicing results in multiple transcript variants.(provided by RefSeq, Jul 2010) Gene Wiki entry for MRPS18A
|
Genomic Views for MRPS18A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MRPS18A gene promoter: HOXA9B HOXA9 GR STAT5B GR-beta E47 Evi-1 Hand1 GR-alpha ATF Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPS18A
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS18A |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.1 HGNC cytogenetic band: 6p21.3MRPS18A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M043639: view genomic region
(about GC identifiers)
Start:
|
43,638,934 bp from pter |
End:
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43,655,549 bp from pter |
Size:
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16,616 bases |
Orientation:
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minus strand |
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Proteins for MRPS18A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RT18A_HUMAN, Q9NVS2 (See
protein sequence)Recommended Name: 28S ribosomal protein S18a, mitochondrial precursor Size: 196 amino acids; 22184 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinctproteins
Subcellular location: Mitochondrion
Secondary accessions: A6XND3 Q5QPA4Alternative splicing: 3 isoforms: Q9NVS2-1 Q9NVS2-2 Q9NVS2-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for MRPS18A: NX_Q9NVS2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NVS2 MRPS18A Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins (2 alternative transcripts):
NP_001180272.1 NP_060605.1 ENSEMBL proteins: ENSP00000361206 ENSP00000361188 ENSP00000398679 Human Recombinant Protein Products for MRPS18A:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MRPS18A for ontologies About GeneDecksing
MRPS18A Antibody Products: Assay Products for MRPS18A: |
Protein
Domains / Families for MRPS18A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPS18A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NVS2ProtoNet protein and cluster: Q9NVS2 1 Blocks protein family: IPB001648 Ribosomal protein S18
UniProtKB/Swiss-Prot: RT18A_HUMAN, Q9NVS2Similarity: Belongs to the ribosomal protein S18P family |
Function for MRPS18A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
NAS | 11279123 |
MRPS18A for ontologies About GeneDecksing
Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS18A (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS18A (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS18A |
|
Pathways & Interactions for MRPS18A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS18A
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
 5/232 Interacting proteins for MRPS18A (Q9NVS22, 3 ENSP000003612064) via UniProtKB, MINT, STRING, and/or I2D (see all 232)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
MRPS18A for ontologies About GeneDecksing
|
Drugs & Compounds for MRPS18A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for MRPS18A Search CenterWatch for drugs/clinical trials and news about MRPS18A / RT18A 
|
Transcripts for MRPS18A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for MRPS18A gene (2 alternative transcripts): NM_001193343.1 NM_018135.3 Unigene Cluster for MRPS18A: Mitochondrial ribosomal protein S18A Hs.520149 [show with all ESTs]Unigene Representative Sequence: AK0746423 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372133(uc003ovy.2 uc003ovz.2 uc003owa.2) ENST00000372116(uc010jyw.3) ENST00000427312
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS18A (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS18A (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MRPS18A (NM_018135) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS18A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS18A  |
Additional cDNA sequence: AB049952.1 AK001410.1 AK074642.1 AK300757.1 AK307183.1 BC010364.1 DQ884400.1 11 DOTS entries: DT.445964 DT.91929236 DT.100771045 DT.97844627 DT.97800878 DT.100029856 DT.92427934 DT.100794042 DT.101958407 DT.120844134 DT.121368290 24/224 AceView cDNA sequences (see all 224): CA417533 BU163246 CA310363 BI819609 AI963815 AA588858 BQ709964 AI580242 CB529177 AI803154 BU580469 BQ448321 AW026474 AA313238 AI245306 CA388706 AA770554 AK001410 CR592702 AA884329 BX401923 AA598895 BQ687706 AI668809 GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS18A About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | |
| SP1: | |   | |   | |   | - |   | |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | - |   | - |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for MRPS18A
|
Expression for MRPS18A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPS18A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GGCCAAACAG
 About this image See MRPS18A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MRPS18A
SOURCE GeneReport for Unigene cluster: Hs.520149 SABiosciences Custom PCR Arrays for MRPS18A
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS18A Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPS18A | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS18A | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS18A | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS18A |
Orthologs for MRPS18A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MRPS18A gene from 7/17 species (see all 17) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Mrps18a1 , 5 |
mitochondrial ribosomal protein S18A1, 5 |
82.99(n)1 81.12(a)1 |
  |
17 (22.86 cM)5 685651 NM_026768.31 NP_081044.11 461109865 |
chicken (Gallus gallus) |
Aves |
MRPS18A1 |
mitochondrial ribosomal protein S18A |
71.11(n) 73.33(a) |
  |
421445 XM_001234386.2 XP_001234387.1 |
lizard (Anolis carolinensis) |
Reptilia |
MRPS18A6 |
-- |
64(a) |
1 ↔ 1 |
GL343854.1(44479-77155) |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.132032 |
Xenopus laevis transcribed sequence with weak similarity more |
72.6(n) |
  |
48062563 |
zebrafish (Danio rerio) |
Actinopterygii |
Dr.147902 |
Transcribed sequence with weak similarity to protein more |
71.2(n) |
  |
BG306910.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
mRpS18A6 |
mitochondrial ribosomal protein S18A |
30(a) |
1 ↔ 1 |
3R(4387628-4388305) |
worm (Caenorhabditis elegans) |
Secernentea |
mrps-18A6 |
-- |
23(a) |
1 ↔ 1 |
III(8330969-8331847) |
ENSEMBL Gene Tree for MRPS18A (if available) TreeFam Gene Tree for MRPS18A (if available)  |
Paralogs for MRPS18A gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for MRPS18A gene
MRPS18A for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MRPS18A PGOHUM00000263114
|
Genomic Variants for MRPS18A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 6 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPS18A (43638934 - 43655549 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MRPS18A: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS18A |
|
Disorders
/ Diseases for MRPS18A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRPS18A for disorders About MalaCards
MRPS18A for disorders About GeneDecksing
OMIM gene information: 611981
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MRPS18A (4 documents) Export disorders for MRPS18A gene to outside databases
|
Publications for MRPS18A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPS18A gene, integrated from 9 sources (see all 16): (articles sorted by number of sources associating them with MRPS18A) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2, 3 Koc E.C.... Spremulli L.L. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 3 Kenmochi N....Tanaka T. (2001)
- Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041)1, 2 Suzuki T....Watanabe K. (2001)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
|
External Searches for MRPS18A gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing MRPS18A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPS18A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPS18A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for MRPS18A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRPS18A gene: Search GeneIP for patents involving MRPS18A
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for MRPS18A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
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| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS18A |
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