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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRPS18A Gene

protein-coding   GIFtS: 51
GCID: GC06M043639

Mitochondrial Ribosomal Protein S18A

  Search for MRPS18A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrial Ribosomal Protein S18A1 2     28S Ribosomal Protein S18a, Mitochondrial2
28S Ribosomal Protein S18-3, Mitochondrial2 3     HumanS18b2
MRP-S18-32 3     S18bmt2
MRP-S18-a2 3     Mitochondrial Ribosomal Protein S18-32
S18mt-a2 3     Mrps18a3
MRPS18-32 5     

External Ids:    HGNC: 145151   Entrez Gene: 551682   Ensembl: ENSG000000960807   OMIM: 6119815   UniProtKB: Q9NVS23   

Export aliases for MRPS18A gene to outside databases

Previous GC identifers: GC06M043641 GC06M043685 GC06M043747 GC06M043357


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRPS18A Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that
has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human
mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18
proteins. A pseudogene corresponding to this gene is found on chromosome 3p. Alternative splicing results in
multiple transcript variants.(provided by RefSeq, Jul 2010)

GeneCards Summary for MRPS18A Gene: 
MRPS18A (mitochondrial ribosomal protein S18A) is a protein-coding gene. Among its related super-pathways are Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS18A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRPS18A gene promoter:
         HOXA9B   HOXA9   GR   STAT5B   GR-beta   E47   Evi-1   Hand1   GR-alpha   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPS18A promoter sequence
   Search SABiosciences Chromatin IP Primers for MRPS18A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS18A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.3

MRPS18A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPS18A gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M043639:  view genomic region     (about GC identifiers)

Start:
43,638,934 bp from pter      End:
43,655,549 bp from pter
Size:
16,616 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RT18A_HUMAN, Q9NVS2 (See protein sequence)
Recommended Name: 28S ribosomal protein S18a, mitochondrial precursor  
Size: 196 amino acids; 22184 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30
distinct proteins
Subcellular location: Mitochondrion
Secondary accessions: A6XND3 Q5QPA4
Alternative splicing: 3 isoforms:  Q9NVS2-1   Q9NVS2-2   Q9NVS2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for MRPS18A: NX_Q9NVS2

Explore proteomics data for MRPS18A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NVS2

  • MRPS18A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MRPS18A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001180272.1  NP_060605.1  

    ENSEMBL proteins: 
     ENSP00000361206   ENSP00000361188   ENSP00000398679  

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    Cloud-Clone Corp. Proteins for MRPS18A 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005739mitochondrion ----
    GO:0005763mitochondrial small ribosomal subunit IDA11279123
    GO:0005840ribosome ----

    MRPS18A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MRPS: Mitochondrial ribosomal proteins / small subunits

    1 InterPro protein domain:
     IPR001648 Ribosomal_S18

    Graphical View of Domain Structure for InterPro Entry Q9NVS2

    ProtoNet protein and cluster: Q9NVS2

    1 Blocks protein domain: IPB001648 Ribosomal protein S18

    UniProtKB/Swiss-Prot: RT18A_HUMAN, Q9NVS2
    Similarity: Belongs to the ribosomal protein S18P family


    MRPS18A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS11279123
         
    MRPS18A for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MRPS18A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    Ribosome0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for MRPS18A):
        Ribosome


    MRPS18A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS18A

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/246 Interacting proteins for MRPS18A (Q9NVS22, 3 ENSP000003612064) via UniProtKB, MINT, STRING, and/or I2D (see all 246)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    AARS2Q5JTZ92MINT-8079030
    AASSQ9UDR52MINT-8079030
    ABCB7O750272MINT-8079030
    ACAD9Q9H8452MINT-8079030
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation NAS11279123

    MRPS18A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRPS18A (RT18A)

    Search CenterWatch for drugs/clinical trials and news about MRPS18A / RT18A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRPS18A gene (2 alternative transcripts): 
    NM_001193343.1  NM_018135.3  

    Unigene Cluster for MRPS18A:

    Mitochondrial ribosomal protein S18A
    Hs.520149  [show with all ESTs]
    Unigene Representative Sequence: AK074642
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372133(uc003ovy.2 uc003ovz.2 uc003owa.2) ENST00000372116(uc010jyw.3)
    ENST00000427312
    miRNA
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    Additional mRNA sequence: 

    AB049952.1 AK001410.1 AK074642.1 AK300757.1 AK307183.1 BC010364.1 DQ884400.1 

    11 DOTS entries:

    DT.445964  DT.91929236  DT.100771045  DT.97844627  DT.97800878  DT.100029856  DT.92427934  DT.100794042 
    DT.101958407  DT.120844134  DT.121368290 

    24/224 AceView cDNA sequences (see all 224):

    AA970383 BQ709964 CR605035 BM554553 AA612570 CR625947 BU849554 AI963815 
    BI756071 BU580469 BM555477 BE791818 AA581980 CR611756 AA370162 BQ687956 
    AA313238 BC010364 BQ925772 CR602940 AW026474 BM928632 AI863932 AA598895 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS18A    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
    SP1:                    -           -               
    SP2:                    -                           
    SP3:                    -     -     -               
    SP4:                                                


    ECgene alternative splicing isoforms for MRPS18A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRPS18A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCAAACAG
    MRPS18A Expression
    About this image


    See MRPS18A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRPS18A

    SOURCE GeneReport for Unigene cluster: Hs.520149
        SABiosciences Custom PCR Arrays for MRPS18A
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MRPS18A gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrps18a1 , 5 mitochondrial ribosomal protein S18A1, 5 82.99(n)1
    81.12(a)1
      17 (22.86 cM)5
    685651  NM_026768.31  NP_081044.11 
     461109865 
    chicken
    (Gallus gallus)
    Aves MRPS18A1 mitochondrial ribosomal protein S18A 71.11(n)
    73.33(a)
      421445  XM_001234386.2  XP_001234387.1 
    lizard
    (Anolis carolinensis)
    Reptilia MRPS18A6
    Uncharacterized protein
    63(a)
    1 ↔ 1
    GL343854.1(44351-77155)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.132032 Xenopus laevis transcribed sequence with weak similarity more 72.6(n)    48062563 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.147902 Transcribed sequence with weak similarity to protein more 71.2(n)    BG306910.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpS18A6
    mitochondrial ribosomal protein S18A
    32(a)
    1 ↔ 1
    3R(4387628-4388305)
    worm
    (Caenorhabditis elegans)
    Secernentea mrps-18A6
    Protein MRPS-18A
    26(a)
    1 ↔ 1
    III(8331041-8331919)


    ENSEMBL Gene Tree for MRPS18A (if available)
    TreeFam Gene Tree for MRPS18A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRPS18A gene

    MRPS18A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MRPS18A
    PGOHUM00000263114


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/381 SNPs in MRPS18A are shown (see all 381)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1393220691,2
    C--43639371(+) GTCCA-/TGCATG 2 -- ut310--------
    rs1839288031,2
    --43639421(+) TATAGC/TTGTGG 2 -- ut310--------
    rs1159247551,2
    C--43639463(+) CAGCAC/GAGGTG 2 -- ut312Minor allele frequency- G:0.01WA EU 1431
    rs2018392771,2
    --43639466(+) CACAGC/GTGCAG 2 -- ut310--------
    rs2010635211,2
    --43639504(+) TCAGTA/GATACA 3 H Y mis1 ut310--------
    rs1457826281,2
    C--43639518(+) TCCAAC/GGTGTT 3 P R mis1 ut310--------
    rs2004614781,2
    --43639528(+) TCTTGA/GGTAGC 3 P S mis1 ut310--------
    rs2018783281,2
    C--43639548(+) CCCTCA/GGAAGG 3 P L mis1 ut310--------
    rs1995308791,2
    --43639569(+) CGGGCA/TTGCGC 3 K M mis1 ut310--------
    rs1382891411,2
    C--43639572(+) GCATGC/TGCACC 3 H R mis1 ut311Minor allele frequency- T:0.00NA 4550

    HapMap Linkage Disequilibrium report for MRPS18A (43638934 - 43655549 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MRPS18A: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing MRPS18A
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPS18A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MRPS18A for disorders           About MalaCards
    OMIM gene information: 611981    OMIM disorders: --


    MRPS18A for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRPS18A
    Human Genome Epidemiology (HuGE) Navigator: MRPS18A (4 documents)

    Export disorders for MRPS18A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRPS18A gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with MRPS18A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2, 3 Koc E.C.... Spremulli L.L. (2001)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    7. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 3 Kenmochi N....Tanaka T. (2001)
    8. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041)1, 2 Suzuki T....Watanabe K. (2001)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55168 HGNC: 14515 AceView: MRPS18A Ensembl:ENSG00000096080 euGenes: HUgn55168
    ECgene: MRPS18A Kegg: 55168 H-InvDB: MRPS18A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRPS18A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRPS18A gene:
    Search GeneIP for patents involving MRPS18A

    GeneCards and IP:
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