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MRPS17 Gene

protein-coding   GIFtS: 52
GCID: GC07P056019

Mitochondrial Ribosomal Protein S17

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Ribosomal Protein S171 2     28S Ribosomal Protein S171
MRP-S172 3     mitochondrial1
RPMS172 3     28S Ribosomal Protein S17, Mitochondrial2
S17mt2 3     HSPC0112

External Ids:    HGNC: 140471   Entrez Gene: 513732   Ensembl: ENSG000002397897   OMIM: 6119805   UniProtKB: Q9Y2R53   

Export aliases for MRPS17 gene to outside databases

Previous GC identifers: GC07P055483 GC07P055727 GC07P055761 GC07P055793 GC07P055987 GC07P055834


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRPS17 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
28S subunit protein that belongs to the ribosomal protein S17P family. The encoded protein is moderately
conserved between human mitochondrial and prokaryotic ribosomal proteins. Pseudogenes corresponding to this gene
are found on chromosomes 1p, 3p, 6q, 14p, 18q, and Xq. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPS17 Gene:
MRPS17 (mitochondrial ribosomal protein S17) is a protein-coding gene. GO annotations related to this gene include structural constituent of ribosome and rRNA binding.

Gene Wiki entry for MRPS17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRPS17 gene promoter:
         RREB-1   Egr-1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MRPS17 promoter sequence
   Search Chromatin IP Primers for MRPS17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRPS17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p11   Ensembl cytogenetic band:  7p11.2   HGNC cytogenetic band: 7p11-q11.21

MRPS17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPS17 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P056019:  view genomic region     (about GC identifiers)

Start:
56,019,512 bp from pter      End:
56,024,192 bp from pter
Size:
4,681 bases      Orientation:
plus strand

2 alternative locations:
Chr7+ 55,954,970-56,022,932      Chr7+,CRA_TCAG 56,023,858-56,027,281     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RT17_HUMAN, Q9Y2R5 (See protein sequence)
Recommended Name: 28S ribosomal protein S17, mitochondrial precursor  
Size: 130 amino acids; 14502 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30
distinct proteins
Secondary accessions: Q86X15

Explore the universe of human proteins at neXtProt for MRPS17: NX_Q9Y2R5

Explore proteomics data for MRPS17 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys41
  • Modification sites at PhosphoSitePlus

  • See MRPS17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057053.1  
    ENSEMBL proteins: 
     ENSP00000285298   ENSP00000401349  

    MRPS17 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MRPS: Mitochondrial ribosomal proteins / small subunits

    2 InterPro protein domains:
     IPR012340 NA-bd_OB-fold
     IPR000266 Ribosomal_S17

    Graphical View of Domain Structure for InterPro Entry Q9Y2R5

    ProtoNet protein and cluster: Q9Y2R5

    1 Blocks protein domain: IPB000266 Ribosomal protein S17

    UniProtKB/Swiss-Prot: RT17_HUMAN, Q9Y2R5
    Similarity: Belongs to the ribosomal protein S17P family


    Find genes that share domains with MRPS17           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS11279123
    GO:0019843rRNA binding IEA--
         
    Find genes that share ontologies with MRPS17           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for MRPS17:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRPS17
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    hsa-miR-204 hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidMRPS17 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RT17_HUMAN, Q9Y2R5: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005763mitochondrial small ribosomal subunit NAS11279123
    GO:0005840ribosome ----

    Find genes that share ontologies with MRPS17           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MRPS17 About    
    See pathways by source

    SuperPathContained pathways About
    1CFTR translational fidelity class I mutations
    Ribosome0.54


    Find genes that share SuperPaths with MRPS17           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for MRPS17):
        Ribosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRPS17
    Interactions:

        Search GeneGlobe Interaction Network for MRPS17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for MRPS17 (Q9Y2R52, 3 ENSP000002852984) via UniProtKB, MINT, STRING, and/or I2D (see all 251)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    PINX1Q96BK53I2D: score=1 
    AARS2Q5JTZ92MINT-8079030
    AASSQ9UDR52MINT-8079030
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation NAS11279123

    Find genes that share ontologies with MRPS17           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRPS17 (RT17)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MRPS17 gene: 
    NM_015969.2  

    Unigene Cluster for MRPS17:

    Mitochondrial ribosomal protein S17
    Hs.44298  [show with all ESTs]
    Unigene Representative Sequence: AK026553
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000285298(uc003trd.3) ENST00000443449
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate MRPS17:
    hsa-miR-204 hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidMRPS17 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MRPS17
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      QuantiTect SYBR Green Assays in human, mouse, rat MRPS17
      QuantiFast Probe-based Assays in human, mouse, rat MRPS17

    Additional mRNA sequence: 

    AB049950.1 AF077035.1 AK026553.1 BC037405.1 BC047445.1 BC054031.2 

    3 DOTS entries:

    DT.111565  DT.92423872  DT.97832629 

    Selected AceView cDNA sequences (see all 115):

    AA596076 AI189259 BF001717 AA609325 NM_015969 AW024426 BE744730 N55773 
    CR605786 BE466705 BC037405 AI637782 CR590495 AA738409 AI640295 BM726653 
    BQ433785 BQ947512 BM272671 BE279197 BU594981 BC047445 BQ879912 BF204834 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRPS17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATGACCAG
    MRPS17 Expression
    About this image

    MRPS17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRPS17 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.44298
        Custom PCR Arrays for MRPS17
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MRPS17 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrps171 , 5 mitochondrial ribosomal protein S171, 5 79.77(n)1
    86.32(a)1
      5 (68.25 cM)5
    662581  NM_025450.41  NP_079726.11 
     1297154975 
    chicken
    (Gallus gallus)
    Aves MRPS171 mitochondrial ribosomal protein S17 74.74(n)
    79.69(a)
      417538  NM_001198647.1  NP_001185576.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia mrps17-prov2 mitochondrial ribosomal protein S17 82.09(n)    BC054221.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1100311 zgc:110031 67.19(n)
    77.34(a)
      553580  NM_001020559.2  NP_001018395.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpS176
    mitochondrial ribosomal protein S17
    23(a)
    1 → many
    2R(20061187-20061958)


    ENSEMBL Gene Tree for MRPS17 (if available)
    TreeFam Gene Tree for MRPS17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MRPS17 gene
    Selected SIMAP similar genes for MRPS17 using alignment to 5 protein entries:     RT17_HUMAN (see all proteins) (see all similar genes):
    ZNF101    ZNF420    ZNF66    ZNF283    ZNF300    ZNF534
    ZNF28    ZNF300P1    ZNF613    ZNF250    ZNF527    ZNF718
    ZNF669    LOC101928664    ZNF568    ZNF615    ZNF761    ZNF649

    Find genes that share paralogs with MRPS17           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for MRPS17
    PGOHUM00000234938 PGOHUM00000244000 PGOHUM00000238080 PGOHUM00000250215 PGOHUM00000250086


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MRPS17 (see all 122)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs605174611,2
    C,F--56017645(+) TGAAGG/TCCAGG 1 -- us2k16Minor allele frequency- T:0.22WA NA CSA 130
    rs1478602311,2
    --56017653(+) AGGCAC/TGGTGG 1 -- us2k10--------
    rs1138394971,2
    C,F--56017742(+) AACGCG/AGTGAA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1813978881,2
    --56017783(+) TTAGCC/TGGGCG 1 -- us2k10--------
    rs731347801,2
    C--56018122(+) TAGCAT/GTAATC 1 -- us2k13Minor allele frequency- G:0.29NA EA 242
    rs345079021,2
    C,F--56018299(+) TCCTGG/ACTTAC 1 -- us2k13Minor allele frequency- A:0.33NA 6
    rs1383119991,2
    C--56018401(+) GCAGGA/TGAATG 1 -- us2k10--------
    rs1409150031,2
    --56018536(+) GTGTGC/TGCGTG 1 -- us2k10--------
    rs1502203111,2
    --56018610(+) AGTAGC/TAAGTT 1 -- us2k10--------
    rs126710911,2
    C,F,A,H--56018666(+) tgataT/Cttttc 1 -- us2k120Minor allele frequency- C:0.45NS EA NA CSA WA 2342

    HapMap Linkage Disequilibrium report for MRPS17 (56019512 - 56024192 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MRPS17:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734447CNV Deletion23290073
    esv2734448CNV Deletion23290073
    dgv1201e199CNV Deletion23128226
    nsv888064CNV Gain21882294
    esv28230CNV Gain+Loss19812545

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611980    OMIM disorders: --


    Find genes that share disorders with MRPS17           About GenesLikeMe

    Genetic Association Database (GAD): MRPS17
    Human Genome Epidemiology (HuGE) Navigator: MRPS17 (1 document)

    Export disorders for MRPS17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRPS17 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with MRPS17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2, 3 Koc E.C.... Spremulli L.L. (J. Biol. Chem. 2001)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041)1, 2 Suzuki T....Watanabe K. (J. Biol. Chem. 2001)
    5. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2 Mao M.... Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (EMBO J. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51373 HGNC: 14047 AceView: MRPS17andFLJ39963 Ensembl:ENSG00000239789 euGenes: HUgn51373
    ECgene: MRPS17 Kegg: 51373 H-InvDB: MRPS17

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRPS17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MRPS17 gene:
    Search GeneIP for patents involving MRPS17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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