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Aliases for MRPS17 Gene

Aliases for MRPS17 Gene

  • Mitochondrial Ribosomal Protein S17 2 3
  • MRP-S17 3 4
  • RPMS17 3 4
  • S17mt 3 4
  • 28S Ribosomal Protein S17, Mitochondrial 3
  • 28S Ribosomal Protein S17 2
  • Mitochondrial 2
  • HSPC011 3

External Ids for MRPS17 Gene

Previous GeneCards Identifiers for MRPS17 Gene

  • GC07P055483
  • GC07P055727
  • GC07P055761
  • GC07P055793
  • GC07P055987
  • GC07P055834
  • GC07P056019

Summaries for MRPS17 Gene

Entrez Gene Summary for MRPS17 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S17P family. The encoded protein is moderately conserved between human mitochondrial and prokaryotic ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 1p, 3p, 6q, 14p, 18q, and Xq. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS17 Gene

MRPS17 (Mitochondrial Ribosomal Protein S17) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome and rRNA binding.

Gene Wiki entry for MRPS17 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS17 Gene

Genomics for MRPS17 Gene

Regulatory Elements for MRPS17 Gene

Transcription factor binding sites by QIAGEN in the MRPS17 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPS17 Gene

55,951,819 bp from pter
55,956,501 bp from pter
4,683 bases
Plus strand

Genomic View for MRPS17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS17 Gene

Proteins for MRPS17 Gene

  • Protein details for MRPS17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S17, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q86X15

    Protein attributes for MRPS17 Gene

    130 amino acids
    Molecular mass:
    14502 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins

neXtProt entry for MRPS17 Gene

Proteomics data for MRPS17 Gene at MOPED

Post-translational modifications for MRPS17 Gene

  • Ubiquitination at Lys41
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS17 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MRPS17 Gene

Domains for MRPS17 Gene

Gene Families for MRPS17 Gene

Protein Domains for MRPS17 Gene

Suggested Antigen Peptide Sequences for MRPS17 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S17P family.
  • Belongs to the ribosomal protein S17P family.
genes like me logo Genes that share domains with MRPS17: view

Function for MRPS17 Gene

Gene Ontology (GO) - Molecular Function for MRPS17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
GO:0019843 rRNA binding IEA --
genes like me logo Genes that share ontologies with MRPS17: view

Phenotypes for MRPS17 Gene

GenomeRNAi human phenotypes for MRPS17:
genes like me logo Genes that share phenotypes with MRPS17: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS17

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRPS17 Gene

Localization for MRPS17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS17 Gene


Subcellular locations from

Jensen Localization Image for MRPS17 Gene COMPARTMENTS Subcellular localization image for MRPS17 gene
Compartment Confidence
mitochondrion 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPS17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit NAS 11279123
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with MRPS17: view

Pathways for MRPS17 Gene

SuperPathways for MRPS17 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
genes like me logo Genes that share pathways with MRPS17: view

Pathways by source for MRPS17 Gene

1 KEGG pathway for MRPS17 Gene

Gene Ontology (GO) - Biological Process for MRPS17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPS17: view

Transcripts for MRPS17 Gene

mRNA/cDNA for MRPS17 Gene

Unigene Clusters for MRPS17 Gene

Mitochondrial ribosomal protein S17:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS17

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS17 Gene

No ASD Table

Relevant External Links for MRPS17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS17 Gene

mRNA expression in normal human tissues for MRPS17 Gene

mRNA differential expression in normal tissues according to GTEx for MRPS17 Gene

This gene is overexpressed in Testis (4.1).

Protein differential expression in normal tissues for MRPS17 Gene

This gene is overexpressed in Lung (24.8), Liver (10.9), and Cervix (6.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS17 Gene

SOURCE GeneReport for Unigene cluster for MRPS17 Gene Hs.44298

genes like me logo Genes that share expressions with MRPS17: view

Expression partners for MRPS17 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MRPS17 Gene

Orthologs for MRPS17 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS17 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS17 35
  • 87.18 (n)
  • 86.92 (a)
-- 36
  • 81 (a)
MRPS17 36
  • 82 (a)
(Canis familiaris)
Mammalia MRPS17 35
  • 87.69 (n)
  • 88.46 (a)
-- 36
  • 74 (a)
(Mus musculus)
Mammalia Mrps17 35
  • 79.77 (n)
  • 86.32 (a)
Mrps17 16
Mrps17 36
  • 87 (a)
(Pan troglodytes)
Mammalia MRPS17 35
  • 99.23 (n)
  • 98.46 (a)
MRPS17 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Mrps17 35
  • 81.1 (n)
  • 84.25 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 80 (a)
(Gallus gallus)
Aves MRPS17 35
  • 74.74 (n)
  • 79.69 (a)
MRPS17 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps17 35
  • 68.52 (n)
  • 70.63 (a)
Str.1461 35
African clawed frog
(Xenopus laevis)
Amphibia mrps17-prov 35
(Danio rerio)
Actinopterygii zgc:110031 35
  • 67.19 (n)
  • 77.34 (a)
MRPS17 36
  • 69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.271 35
fruit fly
(Drosophila melanogaster)
Insecta mRpS17 36
  • 23 (a)
Species with no ortholog for MRPS17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS17 Gene

Gene Tree for MRPS17 (if available)
Gene Tree for MRPS17 (if available)

Paralogs for MRPS17 Gene

genes like me logo Genes that share paralogs with MRPS17: view

No data available for Paralogs for MRPS17 Gene

Variants for MRPS17 Gene

Sequence variations from dbSNP and Humsavar for MRPS17 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs15892 -- 55,955,288(-) TTCAT(A/G)AACAC utr-variant-3-prime
rs1047693 -- 55,955,246(+) TTTTT(C/T)TAAGT utr-variant-3-prime
rs4307293 -- 55,952,420(+) TGGGG(A/G)ACGTG intron-variant
rs5884433 -- 55,953,811(+) CAAAA(-/CT)CTGCC intron-variant
rs7794115 -- 55,955,793(+) agggt(C/T)ttgct downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MRPS17 Gene

Variant ID Type Subtype PubMed ID
esv28230 CNV Gain+Loss 19812545
esv2734447 CNV Deletion 23290073
dgv1201e199 CNV Deletion 23128226
nsv888064 CNV Gain 21882294
esv2734448 CNV Deletion 23290073

Relevant External Links for MRPS17 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS17 Gene

Disorders for MRPS17 Gene

Relevant External Links for MRPS17

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MRPS17 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MRPS17 Gene

Publications for MRPS17 Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4
  2. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PMID: 11402041) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4
  3. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for MRPS17 Gene

Sources for MRPS17 Gene

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