MRPS17 Gene
protein-coding GIFtS: 47
GCID: GC07P056019
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mitochondrial ribosomal protein S17
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Aliases
for MRPS17 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein S171 2 | | MRP-S171 2 3 | | RPMS171 2 3 | | HSPC0111 2 | | S17mt2 3 | | 28S Ribosomal Protein S17, Mitochondrial2 |
Export aliases for MRPS17 gene to outside databasesPrevious GC identifers: GC07P055483 GC07P055727 GC07P055761 GC07P055793 GC07P055987 GC07P055834 |
Summaries
for MRPS17 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPS17:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit proteinthat belongs to the ribosomal protein S17P family. The encoded protein is moderately conserved between humanmitochondrial and prokaryotic ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 1p,3p, 6q, 14p, 18q, and Xq. (provided by RefSeq, Jul 2008)
Gene Wiki entry for MRPS17
|
Genomic Views
for MRPS17 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_033968.6 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPS17 gene promoter:
RREB-1 Egr-1 c-Myb
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPS17
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS17 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p11 Ensembl cytogenetic band: 7p11.2 HGNC cytogenetic band: 7p11-q11.21MRPS17 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P056019: view genomic region
(about GC identifiers)
Start:
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56,019,512 bp from pter |
End:
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56,024,192 bp from pter |
Size:
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4,681 bases |
Orientation:
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plus strand |
2 alternative locations:
| Chr7+ 55,954,970-56,022,932 | Chr7+,CRA_TCAG 56,023,858-56,027,281 |
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Proteins
for MRPS17 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RT17_HUMAN, Q9Y2R5 (See
protein sequence)Recommended Name: 28S ribosomal protein S17, mitochondrial precursor Size: 130 amino acids; 14502 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinctproteins
Subcellular location: Mitochondrion
Secondary accessions: Q86X15Explore the universe of human proteins at neXtProt for MRPS17: NX_Q9Y2R5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y2R5
MRPS17 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057053.1
ENSEMBL proteins: ENSP00000285298 ENSP00000401349
Human Recombinant Protein Products for MRPS17:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MRPS17 for ontologies About GeneDecksing
MRPS17 Antibody Products:
Assay Products for MRPS17: |
Protein
Domains /
Families
for MRPS17 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPS17 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y2R5ProtoNet protein and cluster: Q9Y2R5 1 Blocks protein family: IPB000266 Ribosomal protein S17
UniProtKB/Swiss-Prot: RT17_HUMAN, Q9Y2R5Similarity: Belongs to the ribosomal protein S17P family |
Function
for MRPS17 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
MRPS17 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for MRPS17:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS17 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS17
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for MRPS17 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS17 |
|
Pathways & Interactions
for MRPS17 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS17
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/235 Interacting proteins for MRPS17 (Q9Y2R52, 3 ENSP000002852984) via UniProtKB, MINT, STRING, and/or I2D (see all 235)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
MRPS17 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRPS17 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPS17
Search CenterWatch for drugs/clinical trials and news about MRPS17 / RT17
|
Transcripts
for MRPS17 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPS17 gene: NM_015969.2 Unigene Cluster for MRPS17: Mitochondrial ribosomal protein S17 Hs.44298 [show with all ESTs]Unigene Representative Sequence: AK0265532 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000285298(uc003trd.3) ENST00000443449
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS17 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS17
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRPS17 (NM_015969) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS17 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS17 |
Additional cDNA sequence: AB049950.1 AF077035.1 AK026553.1 BC037405.1 BC047445.1 BC054031.2 3 DOTS entries: DT.111565 DT.92423872 DT.97832629 24/115 AceView cDNA sequences (see all 115): AA738409 AI640295 AW024426 AA609325 CR605786 CR590495 BF001717 AA596076 N55773 BQ433785 BE744730 NM_015969 BE466705 AI189259 BC037405 BM726653 AI637782 CD671862 BQ947512 BF237438 CF141979 BM787747 BE439838 BX099196
GeneLoc Exon Structure
|
Expression
for MRPS17 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPS17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATGACCAG
About this image
See MRPS17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPS17
SOURCE GeneReport for Unigene cluster: Hs.44298
SABiosciences Custom PCR Arrays for MRPS17
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS17
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPS17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS17 |
Orthologs
for MRPS17 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MRPS17 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for MRPS17 (if available)
TreeFam Gene Tree for MRPS17 (if available) |
Paralogs
for MRPS17 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRPS17 gene
18/52 SIMAP similar genes for MRPS17 using alignment to 5 protein entries: RT17_HUMAN (see all proteins)
(see all similar genes):ZNF101 ZNF420 ZNF66 ZNF283 ZNF300 ZNF534
ZNF28 ZNF300P1 ZNF789 ZNF250 ZNF527 ZNF718
ZNF669 ZNF568 ZNF761 ZNF354B ZNF7 ZNF93
MRPS17 for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for MRPS17
PGOHUM00000234938 PGOHUM00000244000 PGOHUM00000238080 PGOHUM00000250215 PGOHUM00000250086
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Genomic Variants
for MRPS17 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPS17 (56019512 - 56024192 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MRPS17
1 CNV: 64828 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS17 |
|
Disorders
/ Diseases
for MRPS17 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRPS17 for disorders About MalaCards
MRPS17 for disorders About GeneDecksing
OMIM gene information: 611980
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MRPS17 (1 document)
Export disorders for MRPS17 gene to outside databases
|
Publications
for MRPS17 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPS17 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with MRPS17) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2, 3 Koc E.C.... Spremulli L.L. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041)1, 2 Suzuki T....Watanabe K. (2001)
- Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2 Mao M.... Chen Z. (1998)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1 Olsen J.V....Mann M. (2006)
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External Searches for MRPS17 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPS17 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPS17 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPS17 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPS17 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MRPS17 gene:
Search GeneIP for patents involving MRPS17
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPS17 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRPS17 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPS17 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS17 | | | OriGene Protein Over-expression Lysate for MRPS17 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRPS17 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS17 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS17 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | MRPS17 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | ThermoFisher Antibodies for MRPS17 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS17 |
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