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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRPS17 Gene

protein-coding   GIFtS: 52
GCID: GC07P056019

Mitochondrial Ribosomal Protein S17

  Search for MRPS17
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrial Ribosomal Protein S171 2     28S Ribosomal Protein S171
MRP-S172 3     mitochondrial1
RPMS172 3     28S Ribosomal Protein S17, Mitochondrial2
S17mt2 3     HSPC0112

External Ids:    HGNC: 140471   Entrez Gene: 513732   Ensembl: ENSG000002397897   OMIM: 6119805   UniProtKB: Q9Y2R53   

Export aliases for MRPS17 gene to outside databases

Previous GC identifers: GC07P055483 GC07P055727 GC07P055761 GC07P055793 GC07P055987 GC07P055834


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRPS17 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
28S subunit protein that belongs to the ribosomal protein S17P family. The encoded protein is moderately
conserved between human mitochondrial and prokaryotic ribosomal proteins. Pseudogenes corresponding to this gene
are found on chromosomes 1p, 3p, 6q, 14p, 18q, and Xq. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPS17 Gene: 
MRPS17 (mitochondrial ribosomal protein S17) is a protein-coding gene. Among its related super-pathways are Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome and rRNA binding.

Gene Wiki entry for MRPS17 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_033968.6  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRPS17 gene promoter:
         RREB-1   Egr-1   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): MRPS17 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRPS17

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p11   Ensembl cytogenetic band:  7p11.2   HGNC cytogenetic band: 7p11-q11.21

MRPS17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPS17 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P056019:  view genomic region     (about GC identifiers)

Start:
56,019,512 bp from pter      End:
56,024,192 bp from pter
Size:
4,681 bases      Orientation:
plus strand

2 alternative locations:
Chr7+,CRA_TCAG 56,023,858-56,027,281      Chr7+ 55,954,970-56,022,932     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RT17_HUMAN, Q9Y2R5 (See protein sequence)
Recommended Name: 28S ribosomal protein S17, mitochondrial precursor  
Size: 130 amino acids; 14502 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30
distinct proteins
Subcellular location: Mitochondrion
Secondary accessions: Q86X15

Explore the universe of human proteins at neXtProt for MRPS17: NX_Q9Y2R5

Explore proteomics data for MRPS17 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y2R5

  • MRPS17 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MRPS17 Protein Expression
    REFSEQ proteins: NP_057053.1  
    ENSEMBL proteins: 
     ENSP00000285298   ENSP00000401349  

    Human Recombinant Protein Products for MRPS17: 
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    Novus Biologicals MRPS17 Protein
    Novus Biologicals MRPS17 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MRPS17 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005763mitochondrial small ribosomal subunit NAS11279123
    GO:0005840ribosome ----

    MRPS17 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MRPS: Mitochondrial ribosomal proteins / small subunits

    2 InterPro protein domains:
     IPR012340 NA-bd_OB-fold
     IPR000266 Ribosomal_S17

    Graphical View of Domain Structure for InterPro Entry Q9Y2R5

    ProtoNet protein and cluster: Q9Y2R5

    1 Blocks protein domain: IPB000266 Ribosomal protein S17

    UniProtKB/Swiss-Prot: RT17_HUMAN, Q9Y2R5
    Similarity: Belongs to the ribosomal protein S17P family


    MRPS17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS11279123
    GO:0019843rRNA binding IEA--
         
    MRPS17 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MRPS17:
     Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for MRPS17 
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    hsa-miR-204 hsa-miR-211
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MRPS17 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    Ribosome0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for MRPS17):
        Ribosome


    MRPS17 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS17

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/249 Interacting proteins for MRPS17 (Q9Y2R52, 3 ENSP000002852984) via UniProtKB, MINT, STRING, and/or I2D (see all 249)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    PINX1Q96BK53I2D: score=1 
    AARS2Q5JTZ92MINT-8079030
    AASSQ9UDR52MINT-8079030
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation NAS11279123

    MRPS17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRPS17 (RT17)

    Search CenterWatch for drugs/clinical trials and news about MRPS17 / RT17

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRPS17 gene: 
    NM_015969.2  

    Unigene Cluster for MRPS17:

    Mitochondrial ribosomal protein S17
    Hs.44298  [show with all ESTs]
    Unigene Representative Sequence: AK026553
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000285298(uc003trd.3) ENST00000443449
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat MRPS17
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate MRPS17:
    hsa-miR-204 hsa-miR-211
    SwitchGear 3'UTR luciferase reporter plasmidMRPS17 3' UTR sequence
    Inhib. RNA
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS17
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS17

    Additional mRNA sequence: 

    AB049950.1 AF077035.1 AK026553.1 BC037405.1 BC047445.1 BC054031.2 

    3 DOTS entries:

    DT.111565  DT.92423872  DT.97832629 

    24/115 AceView cDNA sequences (see all 115):

    NM_015969 AW024426 BE466705 BQ433785 AA596076 AI637782 AA738409 CR605786 
    BF001717 AI189259 AA609325 N55773 CR590495 AI640295 BM726653 BE744730 
    BC037405 BU594981 CF141979 BC054031 BF972770 AA358556 BG163961 NM_182633 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRPS17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATGACCAG
    MRPS17 Expression
    About this image


    See MRPS17 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRPS17

    SOURCE GeneReport for Unigene cluster: Hs.44298
        SABiosciences Custom PCR Arrays for MRPS17
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MRPS17 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrps171 , 5 mitochondrial ribosomal protein S171, 5 79.77(n)1
    86.32(a)1
      5 (68.25 cM)5
    662581  NM_025450.41  NP_079726.11 
     1297154975 
    chicken
    (Gallus gallus)
    Aves MRPS171 mitochondrial ribosomal protein S17 74.74(n)
    79.69(a)
      417538  NM_001198647.1  NP_001185576.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia mrps17-prov2 mitochondrial ribosomal protein S17 82.09(n)    BC054221.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1100311 zgc:110031 67.19(n)
    77.34(a)
      553580  NM_001020559.1  NP_001018395.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpS176
    mitochondrial ribosomal protein S17
    25(a)
    1 → many
    2R(20061187-20061958)


    ENSEMBL Gene Tree for MRPS17 (if available)
    TreeFam Gene Tree for MRPS17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRPS17 gene
    18/55 SIMAP similar genes for MRPS17 using alignment to 5 protein entries:     RT17_HUMAN (see all proteins) (see all similar genes):
    ZNF101    ZNF420    ZNF66    ZNF283    ZNF300    ZNF534
    ZNF28    ZNF300P1    ZNF613    ZNF250    ZNF527    ZNF718
    ZNF669    ZNF568    ZNF615    ZNF761    ZNF649    FIK

    MRPS17 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for MRPS17
    PGOHUM00000234938 PGOHUM00000244000 PGOHUM00000238080 PGOHUM00000250215 PGOHUM00000250086


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/122 SNPs in MRPS17 are shown (see all 122)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs605174611,2
    C,F--56017645(+) TGAAGG/TCCAGG 1 -- us2k16Minor allele frequency- T:0.22WA NA CSA 130
    rs1478602311,2
    --56017653(+) AGGCAC/TGGTGG 1 -- us2k10--------
    rs1138394971,2
    C,F--56017742(+) AACGCG/AGTGAA 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1813978881,2
    --56017783(+) TTAGCC/TGGGCG 1 -- us2k10--------
    rs731347801,2
    C--56018122(+) TAGCAT/GTAATC 1 -- us2k13Minor allele frequency- G:0.29NA EA 242
    rs345079021,2
    C,F--56018299(+) TCCTGG/ACTTAC 1 -- us2k13Minor allele frequency- A:0.33NA 6
    rs1383119991,2
    C--56018401(+) GCAGGA/TGAATG 1 -- us2k10--------
    rs1409150031,2
    --56018536(+) GTGTGC/TGCGTG 1 -- us2k10--------
    rs1502203111,2
    --56018610(+) AGTAGC/TAAGTT 1 -- us2k10--------
    rs126710911,2
    C,F,A,H--56018666(+) tgataT/Cttttc 1 -- us2k120Minor allele frequency- C:0.45NS EA NA CSA WA 2342

    HapMap Linkage Disequilibrium report for MRPS17 (56019512 - 56024192 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for MRPS17:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734447CNV Deletion23290073
    esv2734448CNV Deletion23290073
    dgv1201e199CNV Deletion23128226
    nsv888064CNV Gain21882294
    esv28230CNV Gain+Loss19812545

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MRPS17 for disorders           About MalaCards
    OMIM gene information: 611980    OMIM disorders: --


    MRPS17 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRPS17
    Human Genome Epidemiology (HuGE) Navigator: MRPS17 (1 document)

    Export disorders for MRPS17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRPS17 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with MRPS17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2, 3 Koc E.C.... Spremulli L.L. (2001)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041)1, 2 Suzuki T....Watanabe K. (2001)
    5. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2 Mao M.... Chen Z. (1998)
    6. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51373 HGNC: 14047 AceView: MRPS17andFLJ39963 Ensembl:ENSG00000239789 euGenes: HUgn51373
    ECgene: MRPS17 Kegg: 51373 H-InvDB: MRPS17

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRPS17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRPS17 gene:
    Search GeneIP for patents involving MRPS17

    GeneCards and IP:
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