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Aliases for MRPS16 Gene

Aliases for MRPS16 Gene

  • Mitochondrial Ribosomal Protein S16 2 3
  • MRP-S16 3 4
  • RPMS16 3 4
  • S16mt 3 4
  • CGI-132 3
  • COXPD2 3

External Ids for MRPS16 Gene

Previous GeneCards Identifiers for MRPS16 Gene

  • GC10M073787
  • GC10M074105
  • GC10M074900
  • GC10M074347
  • GC10M074353
  • GC10M074672
  • GC10M074680
  • GC10M075008
  • GC10M069002

Summaries for MRPS16 Gene

Entrez Gene Summary for MRPS16 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S16P family. The encoded protein is one of the most highly conserved ribosomal proteins between mammalian and yeast mitochondria. Three pseudogenes (located at 8q21.3, 20q13.32, 22q12-q13.1) for this gene have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS16 Gene

MRPS16 (Mitochondrial Ribosomal Protein S16) is a Protein Coding gene. Diseases associated with MRPS16 include combined oxidative phosphorylation deficiency 2. Among its related pathways are Organelle biogenesis and maintenance and Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS16 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS16 Gene

Genomics for MRPS16 Gene

Regulatory Elements for MRPS16 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPS16 Gene

73,248,843 bp from pter
73,252,693 bp from pter
3,851 bases
Minus strand

Genomic View for MRPS16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS16 Gene

Proteins for MRPS16 Gene

  • Protein details for MRPS16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S16, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B4E032
    • Q96Q60

    Protein attributes for MRPS16 Gene

    137 amino acids
    Molecular mass:
    15345 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins

    Three dimensional structures from OCA and Proteopedia for MRPS16 Gene

    Alternative splice isoforms for MRPS16 Gene


neXtProt entry for MRPS16 Gene

Proteomics data for MRPS16 Gene at MOPED

Post-translational modifications for MRPS16 Gene

  • Ubiquitination at Lys 64
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS16 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MRPS16 Gene

Domains & Families for MRPS16 Gene

Gene Families for MRPS16 Gene

Protein Domains for MRPS16 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S16P family.
  • Belongs to the ribosomal protein S16P family.
genes like me logo Genes that share domains with MRPS16: view

Function for MRPS16 Gene

Gene Ontology (GO) - Molecular Function for MRPS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
GO:0005515 protein binding IPI 19945174
genes like me logo Genes that share ontologies with MRPS16: view

Phenotypes for MRPS16 Gene

genes like me logo Genes that share phenotypes with MRPS16: view

Animal Model Products

miRNA for MRPS16 Gene

miRTarBase miRNAs that target MRPS16

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS16

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS16 Gene

Localization for MRPS16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS16 Gene


Subcellular locations from

Jensen Localization Image for MRPS16 Gene COMPARTMENTS Subcellular localization image for MRPS16 gene
Compartment Confidence
mitochondrion 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MRPS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IDA 11279123
genes like me logo Genes that share ontologies with MRPS16: view

Pathways & Interactions for MRPS16 Gene

genes like me logo Genes that share pathways with MRPS16: view

Gene Ontology (GO) - Biological Process for MRPS16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPS16: view

No data available for SIGNOR curated interactions for MRPS16 Gene

Drugs & Compounds for MRPS16 Gene

No Compound Related Data Available

Transcripts for MRPS16 Gene

Unigene Clusters for MRPS16 Gene

Mitochondrial ribosomal protein S16:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS16

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS16 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: - -
SP6: - -

Relevant External Links for MRPS16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS16 Gene

mRNA expression in normal human tissues for MRPS16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MRPS16 Gene

This gene is overexpressed in Lung (31.4) and Bone (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS16 Gene

SOURCE GeneReport for Unigene cluster for MRPS16 Gene Hs.180312

genes like me logo Genes that share expression patterns with MRPS16: view

Protein tissue co-expression partners for MRPS16 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS16 Gene

Orthologs for MRPS16 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPS16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS16 35
  • 90.73 (n)
  • 91.73 (a)
MRPS16 36
  • 90 (a)
(Canis familiaris)
Mammalia MRPS16 35
  • 89.63 (n)
  • 88.15 (a)
-- 36
  • 62 (a)
-- 36
  • 60 (a)
(Mus musculus)
Mammalia Mrps16 35
  • 84.69 (n)
  • 91.11 (a)
Mrps16 16
Mrps16 36
  • 91 (a)
(Pan troglodytes)
Mammalia MRPS16 35
  • 99.76 (n)
  • 100 (a)
MRPS16 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrps16 35
  • 83.95 (n)
  • 91.11 (a)
(Monodelphis domestica)
Mammalia MRPS16 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS16 36
  • 73 (a)
(Gallus gallus)
Aves MRPS16 35
  • 64.38 (n)
  • 67.94 (a)
-- 36
  • 63 (a)
-- 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps16 35
  • 64.67 (n)
  • 69.23 (a)
Str.11277 35
(Danio rerio)
Actinopterygii mrps16 35
  • 63.98 (n)
  • 68.55 (a)
mrps16 36
  • 65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8880 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004818 35
  • 55.44 (n)
  • 51.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS16 35
  • 55.96 (n)
  • 51.38 (a)
mRpS16 36
  • 42 (a)
(Caenorhabditis elegans)
Secernentea mrps-16 35
  • 48.51 (n)
  • 44.72 (a)
mrps-16 36
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPS16 36
  • 33 (a)
MRPS16 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7275 36
  • 36 (a)
Species with no ortholog for MRPS16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS16 Gene

Gene Tree for MRPS16 (if available)
Gene Tree for MRPS16 (if available)

Paralogs for MRPS16 Gene

genes like me logo Genes that share paralogs with MRPS16: view

No data available for Paralogs for MRPS16 Gene

Variants for MRPS16 Gene

Sequence variations from dbSNP and Humsavar for MRPS16 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
VAR_031525 -

Variation tolerance for MRPS16 Gene

Residual Variation Intolerance Score: 60.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.78; 58.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS16 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPS16 Gene

Disorders for MRPS16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MRPS16 Gene - From: OMIM, GeneTests, Orphanet, and GeneCards

Disorder Aliases PubMed IDs
combined oxidative phosphorylation deficiency 2
  • agenesis of corpus callosum with dysmorphism and fatal lactic acidosis
- elite association


  • Combined oxidative phosphorylation deficiency 2 (COXPD2) [MIM:610498]: A mitochondrial disease resulting in fatal neonatal metabolic acidosis with agenesis of the corpus callosum. {ECO:0000269 PubMed:15505824}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MRPS16

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MRPS16: view

No data available for Genatlas for MRPS16 Gene

Publications for MRPS16 Gene

  1. The effect of mutated mitochondrial ribosomal proteins S16 and S22 on the assembly of the small and large ribosomal subunits in human mitochondria. (PMID: 18539099) Emdadul Haque M. … Saada A. (Mitochondrion 2008) 23 67
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for MRPS16 Gene

Sources for MRPS16 Gene

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