MRPS16 Gene
protein-coding GIFtS: 52
GCID: GC10M075008
|
|
mitochondrial ribosomal protein S16
| |
Aliases
for MRPS16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein S161 2 | | COXPD22 5 | | MRP-S162 3 | | CGI-1321 | | RPMS162 3 | | 28S Ribosomal Protein S16, Mitochondrial2 | | S16mt2 3 | | |
Export aliases for MRPS16 gene to outside databasesPrevious GC identifers: GC10M073787 GC10M074105 GC10M074900 GC10M074347 GC10M074353 GC10M074672 GC10M074680 GC10M069002 |
Summaries
for MRPS16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPS16:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit proteinthat belongs to the ribosomal protein S16P family. The encoded protein is one of the most highly conserved ribosomalproteins between mammalian and yeast mitochondria. Three pseudogenes (located at 8q21.3, 20q13.32, 22q12-q13.1) forthis gene have been described. (provided by RefSeq, Jul 2008)
Gene Wiki entry for MRPS16
|
Genomic Views
for MRPS16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPS16 gene promoter:
AhR SRF AML1a SRF (504 AA) STAT5A Nkx2-5 CUTL1 Arnt AREB6 NRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPS16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q22.1 Ensembl cytogenetic band: 10q22.2 HGNC cytogenetic band: 10q22.1MRPS16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M075008: view genomic region
(about GC identifiers)
Start:
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75,006,510 bp from pter |
End:
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75,012,451 bp from pter |
Size:
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5,942 bases |
Orientation:
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minus strand |
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Proteins
for MRPS16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RT16_HUMAN, Q9Y3D3 (See
protein sequence)Recommended Name: 28S ribosomal protein S16, mitochondrial precursor Size: 137 amino acids; 15345 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinctproteins
Subcellular location: Mitochondrion
Secondary accessions: Q96Q60Explore the universe of human proteins at neXtProt for MRPS16: NX_Q9Y3D3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y3D3
MRPS16 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057149.1
ENSEMBL proteins: ENSP00000362036 ENSP00000362031 ENSP00000408812
Human Recombinant Protein Products for MRPS16:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MRPS16 for ontologies About GeneDecksing
MRPS16 Antibody Products:
Assay Products for MRPS16: |
Protein
Domains /
Families
for MRPS16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPS16 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y3D3ProtoNet protein and cluster: Q9Y3D3 1 Blocks protein family: IPB000307 Ribosomal protein S16
UniProtKB/Swiss-Prot: RT16_HUMAN, Q9Y3D3Similarity: Belongs to the ribosomal protein S16P family |
Function
for MRPS16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
MRPS16 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS16 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS16
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: MRPS16 (NM_016065) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS16 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS16 |
|
Pathways & Interactions
for MRPS16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS16
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/341 Interacting proteins for MRPS16 (Q9Y3D32, 3 ENSP000003620364) via UniProtKB, MINT, STRING, and/or I2D (see all 341)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
MRPS16 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRPS16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPS16
Search CenterWatch for drugs/clinical trials and news about MRPS16 / RT16
|
Transcripts
for MRPS16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPS16 gene: NM_016065.3 Unigene Cluster for MRPS16: Mitochondrial ribosomal protein S16 Hs.180312 [show with all ESTs]Unigene Representative Sequence: NM_0160656 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000479005 ENST00000372945(uc001jts.1 uc001jtt.1) ENST00000372940
ENST00000471251 ENST00000473427 ENST00000416782(uc010qkh.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS16 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS16
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRPS16 (NM_016065) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS16 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS16 |
Additional cDNA sequence: AB049948.1 AF151890.1 AK025715.1 AK098291.1 BC021106.1 12 DOTS entries: DT.101984294 DT.100650604 DT.100045726 DT.415309 DT.95265506 DT.95265511 DT.121301469 DT.97764748 DT.100643557 DT.100646722 DT.121301313 DT.121301383 24/445 AceView cDNA sequences (see all 445): BG028612 BX448626 BQ690887 BQ007526 BQ954888 AA746286 BM999982 AI091910 BM789217 AA602701 AA742656 CF130105 AI251857 AI203347 BG818234 AA804324 AA729412 BQ420703 CA950680 CR592830 AI798588 CB119328 BE327444 C21554
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS16 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 |
|---|
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| SP1: | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MRPS16
|
Expression
for MRPS16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPS16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTTTAAAA
About this image
See MRPS16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPS16
SOURCE GeneReport for Unigene cluster: Hs.180312
SABiosciences Custom PCR Arrays for MRPS16
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS16
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPS16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS16 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS16 |
Orthologs
for MRPS16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MRPS16 gene from 9/30 species (see all 30) About this table
ENSEMBL Gene Tree for MRPS16 (if available)
TreeFam Gene Tree for MRPS16 (if available) |
Paralogs
for MRPS16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRPS16 gene
MRPS16 for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for MRPS16
PGOHUM00000258487 PGOHUM00000251248 PGOHUM00000247683 PGOHUM00000246577 PGOHUM00000249744
|
Genomic Variants
for MRPS16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPS16 (75006510 - 75012451 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MRPS16: --
Human Gene Mutation Database (HGMD): MRPS16
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS16 |
|
Disorders
/ Diseases
for MRPS16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRPS16 for disorders About GeneDecksing
OMIM gene information: 609204
OMIM disorders: 610498
UniProtKB/Swiss-Prot: RT16_HUMAN, Q9Y3D3
Defects in MRPS16 are the cause of combined oxidative phosphorylation deficiency type 2 (COXPD2) [MIM:610498].Defects in the mitochondrial oxidative phosphorylation system result in devastating, mainly multisystem, diseases.COXPD2 symptoms include fatal neonatal metabolic acidosis with agenesis of the corpus callosum
10  diseases for MRPS16: About MalaCardscombined oxidative phosphorylation deficiency combined oxidative phosphorylation deficiency 2 mitochondrial encephalomyopathy corpus callosum
lactic acidosis encephalomyopathy alzheimer's disease pneumonia
tuberculosis mycobacterium tuberculosis
1 disease from the University of Copenhagen DISEASES database for MRPS16:Mitochondrial encephalomyopathy Human Genome Epidemiology (HuGE) Navigator: MRPS16 (2 documents)
Export disorders for MRPS16 gene to outside databases
|
Publications
for MRPS16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPS16 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with MRPS16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
- Defective mitochondrial translation caused by a ribosomal protein (MRPS16) mutation. (PubMed id 15505824)1, 2 Miller C.... Elpeleg O. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2 Kenmochi N....Tanaka T. (2001)
- Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041)1, 2 Suzuki T....Watanabe K. (2001)
- The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2 Koc E.C.... Spremulli L.L. (2001)
- The effect of mutated mitochondrial ribosomal proteins S16 and S22 on the assembly of the small and large ribosomal subunits in human mitochondria. (PubMed id 18539099)1, 9 Emdadul Haque M....Saada A. (2008)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for MRPS16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPS16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPS16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPS16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPS16 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/MRPS16 |
|
| | |
About This Section
| Patent Information for MRPS16 gene:
Search GeneIP for patents involving MRPS16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPS16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPS16 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS16 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS16 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPS16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS16 |
| |
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| |  |  |  |  | | | | |
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 | | | MRPS16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS16 |
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