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Aliases for MRPS15 Gene

Aliases for MRPS15 Gene

  • Mitochondrial Ribosomal Protein S15 2 3
  • MRP-S15 3 4
  • RPMS15 3 4
  • S15mt 3 4
  • 28S Ribosomal Protein S15, Mitochondrial 3
  • MPR-S15 3
  • DC37 3

External Ids for MRPS15 Gene

Summaries for MRPS15 Gene

Entrez Gene Summary for MRPS15 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S15P family. The encoded protein is more than two times the size of its E. coli counterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 15q and 19q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS15 Gene

MRPS15 (Mitochondrial Ribosomal Protein S15) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS15 Gene

Genomics for MRPS15 Gene

Genomic Location for MRPS15 Gene

Start:
36,455,718 bp from pter
End:
36,464,439 bp from pter
Size:
8,722 bases
Orientation:
Minus strand

Genomic View for MRPS15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS15 Gene

Regulatory Elements for MRPS15 Gene

Transcription factor binding sites by QIAGEN in the MRPS15 gene promoter:

Proteins for MRPS15 Gene

  • Protein details for MRPS15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82914-RT15_HUMAN
    Recommended name:
    28S ribosomal protein S15, mitochondrial
    Protein Accession:
    P82914
    Secondary Accessions:
    • B2RD82
    • Q9H2K1

    Protein attributes for MRPS15 Gene

    Size:
    257 amino acids
    Molecular mass:
    29842 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins
    SequenceCaution:
    • Sequence=AAG44697.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for MRPS15 Gene

Proteomics data for MRPS15 Gene at MOPED

Post-translational modifications for MRPS15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS15 Gene

Domains for MRPS15 Gene

Gene Families for MRPS15 Gene

HGNC:
  • MRPS :Mitochondrial ribosomal proteins / small subunits

Protein Domains for MRPS15 Gene

Suggested Antigen Peptide Sequences for MRPS15 Gene

Graphical View of Domain Structure for InterPro Entry

P82914

UniProtKB/Swiss-Prot:

RT15_HUMAN
Family:
  • Belongs to the ribosomal protein S15P family.:
    • P82914
genes like me logo Genes that share domains with MRPS15: view

Function for MRPS15 Gene

Gene Ontology (GO) - Molecular Function for MRPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPS15: view

miRNA for MRPS15 Gene

miRTarBase miRNAs that target MRPS15

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPS15 Gene

Localization for MRPS15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS15 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS15 Gene COMPARTMENTS Subcellular localization image for MRPS15 gene
Compartment Confidence
mitochondrion 5
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for MRPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IDA 11279123
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with MRPS15: view

Pathways for MRPS15 Gene

SuperPathways for MRPS15 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with MRPS15: view

Pathways by source for MRPS15 Gene

1 KEGG pathway for MRPS15 Gene

Gene Ontology (GO) - Biological Process for MRPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPS15: view

Transcripts for MRPS15 Gene

mRNA/cDNA for MRPS15 Gene

Unigene Clusters for MRPS15 Gene

Mitochondrial ribosomal protein S15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - - -
SP3:
SP4: - - - - - -

Relevant External Links for MRPS15 Gene

GeneLoc Exon Structure for
MRPS15
ECgene alternative splicing isoforms for
MRPS15

Expression for MRPS15 Gene

mRNA expression in normal human tissues for MRPS15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS15 Gene

SOURCE GeneReport for Unigene cluster for MRPS15 Gene Hs.352839

genes like me logo Genes that share expressions with MRPS15: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS15 Gene

Orthologs for MRPS15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPS15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS15 35
  • 98.7 (n)
  • 98.05 (a)
MRPS15 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 63 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
MRPS15 35
  • 82.42 (n)
  • 71.87 (a)
dog
(Canis familiaris)
Mammalia MRPS15 35
  • 82.64 (n)
  • 74.48 (a)
MRPS15 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrps15 35
  • 78.27 (n)
  • 65.6 (a)
Mrps15 16
Mrps15 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPS15 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS15 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps15 35
  • 77.12 (n)
  • 63.92 (a)
chicken
(Gallus gallus)
Aves MRPS15 35
  • 57.29 (n)
  • 48.44 (a)
MRPS15 36
  • 39 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPS15 36
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps15 35
  • 60.4 (n)
  • 60 (a)
Str.15348 35
zebrafish
(Danio rerio)
Actinopterygii mrps15 35
  • 51.26 (n)
  • 43.4 (a)
mrps15 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bonsai 36
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPS28 38
Species with no ortholog for MRPS15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS15 Gene

ENSEMBL:
Gene Tree for MRPS15 (if available)
TreeFam:
Gene Tree for MRPS15 (if available)

Paralogs for MRPS15 Gene

Pseudogenes.org Pseudogenes for MRPS15 Gene

genes like me logo Genes that share paralogs with MRPS15: view

No data available for Paralogs for MRPS15 Gene

Variants for MRPS15 Gene

Sequence variations from dbSNP and Humsavar for MRPS15 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs7065 -- 36,462,132(+) GTAGA(A/G)GGAGG reference, synonymous-codon
rs1053249 -- 36,455,887(+) AAGGC(C/T)CTTCT reference, synonymous-codon
rs1063834 -- 36,455,816(+) TTGGT(A/G)TGGCT missense, reference
rs1140884 -- 36,455,800(+) CTGTC(C/T)TTGAG reference, synonymous-codon
rs1538634 -- 36,455,770(+) AGAAA(G/T)AAATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPS15 Gene

Variant ID Type Subtype PubMed ID
nsv509202 CNV Insertion 20534489
nsv461073 CNV Loss 19166990
nsv520839 CNV Loss 19592680

Relevant External Links for MRPS15 Gene

HapMap Linkage Disequilibrium report
MRPS15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS15 Gene

Disorders for MRPS15 Gene

Relevant External Links for MRPS15

Genetic Association Database (GAD)
MRPS15
Human Genome Epidemiology (HuGE) Navigator
MRPS15
genes like me logo Genes that share disorders with MRPS15: view

No data available for UniProtKB/Swiss-Prot for MRPS15 Gene

Publications for MRPS15 Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 3 4
  2. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PMID: 11402041) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for MRPS15 Gene

Sources for MRPS15 Gene

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