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Aliases for MRPS15 Gene

Aliases for MRPS15 Gene

  • Mitochondrial Ribosomal Protein S15 2 3 5
  • MRP-S15 3 4
  • RPMS15 3 4
  • S15mt 3 4
  • 28S Ribosomal Protein S15, Mitochondrial 3
  • MPR-S15 3
  • DC37 3

External Ids for MRPS15 Gene

Previous GeneCards Identifiers for MRPS15 Gene

  • GC01M036743
  • GC01M035976
  • GC01M036347
  • GC01M036349
  • GC01M036590
  • GC01M036695
  • GC01M036921
  • GC01M035037

Summaries for MRPS15 Gene

Entrez Gene Summary for MRPS15 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S15P family. The encoded protein is more than two times the size of its E. coli counterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 15q and 19q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS15 Gene

MRPS15 (Mitochondrial Ribosomal Protein S15) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Viral mRNA Translation. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS15 Gene

Genomics for MRPS15 Gene

Regulatory Elements for MRPS15 Gene

Enhancers for MRPS15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F036484 1.6 FANTOM5 Ensembl ENCODE 12.1 -22.9 -22939 4.8 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 SP5 CSF3R OSCP1 CLSPN MRPS15 ENSG00000201448 THRAP3 STK40 MAP7D1 SH3D21 LSM10
GH01F036516 1.1 Ensembl ENCODE 12 -52.2 -52162 1.2 BCOR HDGF CTCF ZNF792 ZMYM3 ZNF48 ZNF644 ZNF2 RAD21 HBP1 OSCP1 CSF3R MRPS15 GC01M036518
GH01F036463 1.2 ENCODE 0.8 -0.3 -279 2.9 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF143 SP3 NFYC THRAP3 STK40 EVA1B OSCP1 LOC105378647 MRPS15 CSF3R
GH01F036457 1.1 Ensembl ENCODE 0.4 +6.0 6009 1.7 ATF1 ARID4B ZSCAN9 CHAMP1 RARA ZNF766 SCRT2 ZNF143 CREM MIXL1 ENSG00000271914 TFAP2E OSCP1 AGO1 LSM10 GC01P036455 MRPS15
GH01F036481 0.8 ENCODE 0.3 -18.1 -18082 2.8 HDGF PKNOX1 ZFP64 ARID4B MAX CEBPG ZNF48 ZSCAN9 HBP1 ZKSCAN1 OSCP1 ENSG00000201448 CSF3R MRPS15
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPS15 on UCSC Golden Path with GeneCards custom track

Promoters for MRPS15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000076357 339 1801 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF143 SP3 NFYC

Transcription factor binding sites by QIAGEN in the MRPS15 gene promoter:

Genomic Location for MRPS15 Gene

36,455,718 bp from pter
36,464,439 bp from pter
8,722 bases
Minus strand

Genomic View for MRPS15 Gene

Genes around MRPS15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS15 Gene

Proteins for MRPS15 Gene

  • Protein details for MRPS15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S15, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B2RD82
    • Q9H2K1

    Protein attributes for MRPS15 Gene

    257 amino acids
    Molecular mass:
    29842 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
    • Sequence=AAG44697.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS15 Gene

neXtProt entry for MRPS15 Gene

Post-translational modifications for MRPS15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS15 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS15 Gene

Domains & Families for MRPS15 Gene

Gene Families for MRPS15 Gene

Protein Domains for MRPS15 Gene

Suggested Antigen Peptide Sequences for MRPS15 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S15P family.
  • Belongs to the ribosomal protein S15P family.
genes like me logo Genes that share domains with MRPS15: view

Function for MRPS15 Gene

Gene Ontology (GO) - Molecular Function for MRPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome NAS 11279123
GO:0019843 rRNA binding IBA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with MRPS15: view

Phenotypes for MRPS15 Gene

genes like me logo Genes that share phenotypes with MRPS15: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS15 Gene

Localization for MRPS15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS15 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS15 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for MRPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome IEA --
GO:0005763 mitochondrial small ribosomal subunit IDA 11279123
genes like me logo Genes that share ontologies with MRPS15: view

Pathways & Interactions for MRPS15 Gene

genes like me logo Genes that share pathways with MRPS15: view

Gene Ontology (GO) - Biological Process for MRPS15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 11279123
GO:0032543 mitochondrial translation ISS 11402041
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS15: view

No data available for SIGNOR curated interactions for MRPS15 Gene

Transcripts for MRPS15 Gene

Unigene Clusters for MRPS15 Gene

Mitochondrial ribosomal protein S15:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS15 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - - -
SP4: - - - - - -

Relevant External Links for MRPS15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for MRPS15 Gene

Protein differential expression in normal tissues from HIPED for MRPS15 Gene

This gene is overexpressed in Breast (18.9), Pancreas (10.0), and Tlymphocyte (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS15 Gene

Protein tissue co-expression partners for MRPS15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS15 Gene:


SOURCE GeneReport for Unigene cluster for MRPS15 Gene:

genes like me logo Genes that share expression patterns with MRPS15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS15 Gene

Orthologs for MRPS15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPS15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MRPS15 34 35
  • 98.7 (n)
(Canis familiaris)
Mammalia MRPS15 34 35
  • 82.64 (n)
(Bos Taurus)
Mammalia MRPS15 34
  • 82.42 (n)
-- 35
  • 72 (a)
-- 35
  • 63 (a)
(Mus musculus)
Mammalia Mrps15 34 16 35
  • 78.27 (n)
(Rattus norvegicus)
Mammalia Mrps15 34
  • 77.12 (n)
(Ornithorhynchus anatinus)
Mammalia MRPS15 35
  • 66 (a)
(Monodelphis domestica)
Mammalia MRPS15 35
  • 57 (a)
(Gallus gallus)
Aves MRPS15 34 35
  • 57.29 (n)
(Anolis carolinensis)
Reptilia MRPS15 35
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps15 34
  • 60.4 (n)
Str.15348 34
(Danio rerio)
Actinopterygii mrps15 34 35
  • 51.26 (n)
fruit fly
(Drosophila melanogaster)
Insecta bonsai 35
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPS28 37
Species where no ortholog for MRPS15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPS15 Gene

Gene Tree for MRPS15 (if available)
Gene Tree for MRPS15 (if available)

Paralogs for MRPS15 Gene Pseudogenes for MRPS15 Gene

genes like me logo Genes that share paralogs with MRPS15: view

No data available for Paralogs for MRPS15 Gene

Variants for MRPS15 Gene

Sequence variations from dbSNP and Humsavar for MRPS15 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1053249 -- 36,455,887(+) AAGGC(C/T)CTTCT reference, synonymous-codon
rs1063834 -- 36,455,816(+) TTGGT(A/G)TGGCT reference, missense
rs10689890 -- 36,464,058(+) TGTAT(-/TCC)ATCTC intron-variant
rs10796885 -- 36,463,302(+) ATATA(C/T)TTAAT intron-variant
rs111339605 -- 36,463,777(+) CTTCC(A/G)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS15 Gene

Variant ID Type Subtype PubMed ID
esv3365853 CNV duplication 20981092
nsv461073 CNV loss 19166990
nsv509202 CNV insertion 20534489
nsv520839 CNV loss 19592680
nsv546000 CNV loss 21841781

Variation tolerance for MRPS15 Gene

Residual Variation Intolerance Score: 68.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS15 Gene

Disorders for MRPS15 Gene

Relevant External Links for MRPS15

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPS15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS15 Gene

Publications for MRPS15 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 3 4 64
  5. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PMID: 11402041) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4 64

Products for MRPS15 Gene

Sources for MRPS15 Gene

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