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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRPS15 Gene

protein-coding   GIFtS: 51
GCID: GC01M036921

Mitochondrial Ribosomal Protein S15

  Search for MRPS15
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Mitochondrial Ribosomal Protein S151 2
MRP-S152 3
RPMS152 3
S15mt2 3
28S Ribosomal Protein S15, Mitochondrial2
MPR-S152

External Ids:    HGNC: 145041   Entrez Gene: 649602   Ensembl: ENSG000001168987   OMIM: 6119795   UniProtKB: P829143   

Export aliases for MRPS15 gene to outside databases

Previous GC identifers: GC01M036743 GC01M035976 GC01M036347 GC01M036349 GC01M036590 GC01M036695 GC01M035037


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRPS15 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
28S subunit protein that belongs to the ribosomal protein S15P family. The encoded protein is more than two times
the size of its E. coli counterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the
encoded protein is the least conserved among small subunit ribosomal proteins. Pseudogenes corresponding to this
gene are found on chromosomes 15q and 19q. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPS15 Gene: 
MRPS15 (mitochondrial ribosomal protein S15) is a protein-coding gene. Among its related super-pathways are Viral mRNA Translation. GO annotations related to this gene include structural constituent of ribosome.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRPS15 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPS15 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRPS15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.3   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.3

MRPS15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPS15 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M036921:  view genomic region     (about GC identifiers)

Start:
36,921,319 bp from pter      End:
36,930,040 bp from pter
Size:
8,722 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RT15_HUMAN, P82914 (See protein sequence)
Recommended Name: 28S ribosomal protein S15, mitochondrial precursor  
Size: 257 amino acids; 29842 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30
distinct proteins
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAG44697.1; Type=Erroneous initiation;
Secondary accessions: B2RD82 Q9H2K1

Explore the universe of human proteins at neXtProt for MRPS15: NX_P82914

Explore proteomics data for MRPS15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P82914

  • MRPS15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    MRPS15 Protein Expression
    REFSEQ proteins: NP_112570.2  
    ENSEMBL proteins: 
     ENSP00000362208  

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    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005739mitochondrion IDA--
    GO:0005763mitochondrial small ribosomal subunit IDA11279123
    GO:0005840ribosome ----
    GO:0031965nuclear membrane IDA--

    MRPS15 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MRPS: Mitochondrial ribosomal proteins / small subunits

    3 InterPro protein domains:
     IPR000589 Ribosomal_S15
     IPR009068 S15_NS1_RNA-bd
     IPR005290 Ribosomal_S15_bac-type

    Graphical View of Domain Structure for InterPro Entry P82914

    ProtoNet protein and cluster: P82914

    UniProtKB/Swiss-Prot: RT15_HUMAN, P82914
    Similarity: Belongs to the ribosomal protein S15P family


    MRPS15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome NAS11279123
         
    MRPS15 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for MRPS15 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Viral mRNA Translation
    Ribosome0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for MRPS15):
        Ribosome


    MRPS15 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/321 Interacting proteins for MRPS15 (P829142, 3 ENSP000003622084) via UniProtKB, MINT, STRING, and/or I2D (see all 321)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTCD3Q96EY72, 3, ENSP000002546304MINT-7033995 MINT-6488590 MINT-8079030 I2D: score=1 STRING: ENSP00000254630
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    MRPS27Q925522MINT-8387463 MINT-6488590 MINT-8079030
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation NAS11279123

    MRPS15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRPS15 (RT15)

    Search CenterWatch for drugs/clinical trials and news about MRPS15 / RT15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRPS15 gene: 
    NM_031280.3  

    Unigene Cluster for MRPS15:

    Mitochondrial ribosomal protein S15
    Hs.352839  [show with all ESTs]
    Unigene Representative Sequence: AB209905
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373116(uc001cas.2) ENST00000488606 ENST00000477040 ENST00000462067

    miRNA
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    Additional mRNA sequence: 

    AB049946.1 AB209905.1 AF265439.1 AK125230.1 AK302633.1 AK315441.1 BC031336.1 

    10 DOTS entries:

    DT.65286176  DT.92037264  DT.216786  DT.95080025  DT.92433695  DT.100819349  DT.80100190  DT.101976748 
    DT.121420025  DT.92433705 

    24/220 AceView cDNA sequences (see all 220):

    BE675821 AI754433 AA455451 BM824436 BG285981 BM700236 AA335720 AI243928 
    AI348254 AW139530 AI352374 BU626859 BU626317 BM700322 AA922390 BM793718 
    BM670515 CN478469 H46968 AI684218 AI139576 AI918044 CB243677 F25511 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS15    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                                -                       -                           
    SP2:                                -     -                 -                           
    SP3:                                                                                    
    SP4:                    -     -     -     -     -     -                                 


    ECgene alternative splicing isoforms for MRPS15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRPS15 expression in normal human tissues (normalized intensities)      MRPS15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGAGGGTCG
    MRPS15 Expression
    About this image


    MRPS15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Islets of Langerhans
             pancreas ; exocrine glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   

    See MRPS15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRPS15

    SOURCE GeneReport for Unigene cluster: Hs.352839
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for MRPS15 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrps151 , 5 mitochondrial ribosomal protein S151, 5 78.27(n)1
    65.6(a)1
      4 (59.80 cM)5
    664071  NM_025544.21  NP_079820.21 
     1260469255 
    chicken
    (Gallus gallus)
    Aves LOC7702611 28S ribosomal protein S15, mitochondrial-like 56.12(n)
    47.25(a)
      770261  XM_001233591.2  XP_001233592.2 
    lizard
    (Anolis carolinensis)
    Reptilia MRPS156
    Uncharacterized protein
    44(a)
    1 ↔ 1
    GL343610.1(312014-318199)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.153482 Transcribed sequence with weak similarity to protein more 68.92(n)    CF345160.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mrps151 mitochondrial ribosomal protein S15 50.63(n)
    42.26(a)
      436758  NM_001002485.1  NP_001002485.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bonsai6
    bonsai
    23(a)
    1 ↔ 1
    2R(18525277-18526373)
    worm
    (Caenorhabditis elegans)
    Secernentea mrps-156
    28S ribosomal protein S15, mitochondrial
    15(a)
    1 ↔ 1
    I(8691042-8692491)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MRPS28(YDR337W)4 Mitochondrial ribosomal protein of the small subunit   --   4(1146319-1147179) 851937  NP_010624.1 


    ENSEMBL Gene Tree for MRPS15 (if available)
    TreeFam Gene Tree for MRPS15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRPS15 gene

    MRPS15 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for MRPS15
    PGOHUM00000246848 PGOHUM00000234717


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/275 SNPs in MRPS15 are shown (see all 275)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1858084481,2
    --36920896(+) CCTAGC/TATATA 1 -- ds50010--------
    rs1469317851,2
    C--36920947(+) TATTTC/TTCATT 1 -- ds50010--------
    rs168230371,2
    C,F,H--36920953(+) TCATTC/TTCCCC 1 -- ds500120Minor allele frequency- T:0.15NA NS EA CSA WA 2485
    rs1135937071,2
    F--36920960(+) CCCCGT/CTCTCT 1 -- ds50012Minor allele frequency- C:0.10CSA WA 120
    rs1906275891,2
    --36920984(+) CTCTCC/TAGACT 1 -- ds50010--------
    rs769789071,2
    C,F--36921029(+) GGAGGC/ACTTCC 1 -- ds50011Minor allele frequency- A:0.28EA 120
    rs1475811871,2
    --36921092(+) AAGGCA/GGCTCC 1 -- ds50010--------
    rs1490631821,2
    C--36921124(+) GCCGGA/CCACAC 1 -- ds50010--------
    rs590773571,2
    C--36921154(+) GCTCTG/ATCTTG 1 -- ds50012Minor allele frequency- A:0.10WA 120
    rs1433326801,2
    --36921221(+) AGGCAG/TGTCAT 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for MRPS15 (36921319 - 36930040 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for MRPS15:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509202CNV Insertion20534489
    nsv461073CNV Loss19166990
    nsv520839CNV Loss19592680

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MRPS15 for disorders           About MalaCards
    OMIM gene information: 611979    OMIM disorders: --


    MRPS15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRPS15
    Human Genome Epidemiology (HuGE) Navigator: MRPS15 (1 document)

    Export disorders for MRPS15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRPS15 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with MRPS15)
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    1. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041)1, 2 Suzuki T....Watanabe K. (2001)
    5. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2 Koc E.C.... Spremulli L.L. (2001)
    6. A large set of estrogen receptor b-interacting protein s identified by tandem affinity purification in hormone-responsive human breast cancer cell nuclei. (PubMed id 21182203)1 Nassa G....Weisz A. (2011)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. Genome-wide meta-analysis for severe diabetic retinop athy. (PubMed id 21441570)1 Grassi M.A....Nicolae D.L. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64960 HGNC: 14504 AceView: MRPS15 Ensembl:ENSG00000116898 euGenes: HUgn64960
    ECgene: MRPS15 Kegg: 64960 H-InvDB: MRPS15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRPS15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRPS15 gene:
    Search GeneIP for patents involving MRPS15

    GeneCards and IP:
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