MRPS15 Gene
protein-coding GIFtS: 46
GCID: GC01M036921
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|
mitochondrial ribosomal protein S15
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Aliases
for MRPS15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein S151 2 | | FLJ115641 | | MRP-S152 3 | | 28S Ribosomal Protein S15, Mitochondrial2 | | RPMS152 3 | | MPR-S152 | | S15mt2 3 | | |
Export aliases for MRPS15 gene to outside databasesPrevious GC identifers: GC01M036743 GC01M035976 GC01M036347 GC01M036349 GC01M036590 GC01M036695 GC01M035037 |
Summaries
for MRPS15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPS15:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit proteinthat belongs to the ribosomal protein S15P family. The encoded protein is more than two times the size of its E. colicounterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the encoded protein is the leastconserved among small subunit ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 15qand 19q. (provided by RefSeq, Jul 2008)
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Genomic Views
for MRPS15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPS15 gene promoter:
AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPS15
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p34.3 Ensembl cytogenetic band: 1p34.3 HGNC cytogenetic band: 1p34.3MRPS15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M036921: view genomic region
(about GC identifiers)
Start:
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36,921,319 bp from pter |
End:
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36,930,040 bp from pter |
Size:
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8,722 bases |
Orientation:
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minus strand |
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Proteins
for MRPS15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RT15_HUMAN, P82914 (See
protein sequence)Recommended Name: 28S ribosomal protein S15, mitochondrial precursor Size: 257 amino acids; 29842 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinctproteins
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAG44697.1; Type=Erroneous initiation;
Secondary accessions: B2RD82 Q9H2K1Explore the universe of human proteins at neXtProt for MRPS15: NX_P82914
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P82914
MRPS15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_112570.2
ENSEMBL proteins: ENSP00000362208
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MRPS15 for ontologies About GeneDecksing
MRPS15 Antibody Products:
Assay Products for MRPS15: |
Protein
Domains /
Families
for MRPS15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPS15 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P82914ProtoNet protein and cluster: P82914 UniProtKB/Swiss-Prot: RT15_HUMAN, P82914Similarity: Belongs to the ribosomal protein S15P family |
Function
for MRPS15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS15
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRPS15 (NM_031280) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS15 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS15 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS15 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
NAS | 11279123 |
MRPS15 for ontologies About GeneDecksing
|
Pathways & Interactions
for MRPS15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS15
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/307 Interacting proteins for MRPS15 (P829142, 3 ENSP000003622084) via UniProtKB, MINT, STRING, and/or I2D (see all 307)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
MRPS15 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRPS15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPS15
Search CenterWatch for drugs/clinical trials and news about MRPS15 / RT15
|
Transcripts
for MRPS15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPS15 gene: NM_031280.3 Unigene Cluster for MRPS15: Mitochondrial ribosomal protein S15 Hs.352839 [show with all ESTs]Unigene Representative Sequence: AB2099054 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000373116(uc001cas.2) ENST00000488606 ENST00000477040 ENST00000462067
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS15
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRPS15 (NM_031280) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS15 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS15 |
Additional cDNA sequence: AB049946.1 AB209905.1 AF265439.1 AK125230.1 AK302633.1 AK315441.1 BC031336.1 10 DOTS entries: DT.65286176 DT.92037264 DT.216786 DT.95080025 DT.92433695 DT.100819349 DT.80100190 DT.101976748 DT.121420025 DT.92433705 24/220 AceView cDNA sequences (see all 220): AI243928 AI348254 H46968 BG285981 AI918044 CB243677 F25511 BU626317 AA455451 BE675821 AW139530 CN478469 AI684218 BM824436 BU626859 AI139576 AA922390 BM793718 AA335720 BM700236 BM670515 AI754433 AI352374 BM700322
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS15 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for MRPS15
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Expression
for MRPS15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPS15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGAGGGTCG
About this image
See MRPS15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPS15
SOURCE GeneReport for Unigene cluster: Hs.352839
SABiosciences Custom PCR Arrays for MRPS15
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS15
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPS15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS15 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS15 |
Orthologs
for MRPS15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MRPS15 gene from 7/18 species (see all 18) About this table
ENSEMBL Gene Tree for MRPS15 (if available)
TreeFam Gene Tree for MRPS15 (if available) |
Paralogs
for MRPS15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRPS15 gene
MRPS15 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for MRPS15
PGOHUM00000246848 PGOHUM00000234717
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Genomic Variants
for MRPS15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPS15 (36921319 - 36930040 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MRPS15: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS15 |
|
Disorders
/ Diseases
for MRPS15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRPS15 for disorders About MalaCards
MRPS15 for disorders About GeneDecksing
OMIM gene information: 611979
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MRPS15 (1 document)
Export disorders for MRPS15 gene to outside databases
|
Publications
for MRPS15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPS15 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with MRPS15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041)1, 2 Suzuki T....Watanabe K. (2001)
- The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2 Koc E.C.... Spremulli L.L. (2001)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Genome-wide meta-analysis for severe diabetic retinop athy. (PubMed id 21441570)1 Grassi M.A....Nicolae D.L. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
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External Searches for MRPS15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPS15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPS15 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPS15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPS15 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MRPS15 gene:
Search GeneIP for patents involving MRPS15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPS15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRPS15 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPS15 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS15 | | | OriGene Protein Over-expression Lysate for MRPS15 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRPS15 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS15 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS15 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPS15 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS15 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS15 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPS15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS15 |
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 | | | MRPS15 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS15 |
|  |  |  | | | | Search ThermoFisher Antibodies for MRPS15 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS15 |
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