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Aliases for MRPS14 Gene

Aliases for MRPS14 Gene

  • Mitochondrial Ribosomal Protein S14 2 3
  • MRP-S14 3 4
  • S14mt 3 4
  • 28S Ribosomal Protein S14, Mitochondrial 3
  • Mitochondrial 28S Ribosomal Protein S14 3
  • DJ262D12.2 3
  • HSMRPS14 3

External Ids for MRPS14 Gene

Previous GeneCards Identifiers for MRPS14 Gene

  • GC01M172507
  • GC01M170411
  • GC01M171562
  • GC01M172222
  • GC01M171714
  • GC01M173248
  • GC01M146209

Summaries for MRPS14 Gene

Entrez Gene Summary for MRPS14 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S14P family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

GeneCards Summary for MRPS14 Gene

MRPS14 (Mitochondrial Ribosomal Protein S14) is a Protein Coding gene. Among its related pathways are CFTR translational fidelity (class I mutations). GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS14 Gene

Genomics for MRPS14 Gene

Regulatory Elements for MRPS14 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPS14 Gene

175,010,789 bp from pter
175,023,455 bp from pter
12,667 bases
Minus strand

Genomic View for MRPS14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS14 Gene

Proteins for MRPS14 Gene

  • Protein details for MRPS14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S14, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q5R358

    Protein attributes for MRPS14 Gene

    128 amino acids
    Molecular mass:
    15139 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Interacts with LIAT1 (By similarity).

neXtProt entry for MRPS14 Gene

Proteomics data for MRPS14 Gene at MOPED

Post-translational modifications for MRPS14 Gene

No Post-translational modifications

Other Protein References for MRPS14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS14 Gene

Domains for MRPS14 Gene

Gene Families for MRPS14 Gene

  • MRPS :Mitochondrial ribosomal proteins / small subunits

Protein Domains for MRPS14 Gene


Suggested Antigen Peptide Sequences for MRPS14 Gene

Graphical View of Domain Structure for InterPro Entry



  • O60783
  • Belongs to the ribosomal protein S14P family.
genes like me logo Genes that share domains with MRPS14: view

Function for MRPS14 Gene

Gene Ontology (GO) - Molecular Function for MRPS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome TAS 10938081
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MRPS14: view

Animal Model Products

miRNA for MRPS14 Gene

miRTarBase miRNAs that target MRPS14

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPS14 Gene

Localization for MRPS14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS14 Gene


Subcellular locations from

Jensen Localization Image for MRPS14 Gene COMPARTMENTS Subcellular localization image for MRPS14 gene
Compartment Confidence
mitochondrion 5
nucleus 4
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for MRPS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 10938081
GO:0005763 mitochondrial small ribosomal subunit IBA --
genes like me logo Genes that share ontologies with MRPS14: view

Pathways for MRPS14 Gene

SuperPathways for MRPS14 Gene

Superpath Contained pathways
1 CFTR translational fidelity (class I mutations)
genes like me logo Genes that share pathways with MRPS14: view

Pathways by source for MRPS14 Gene

1 KEGG pathway for MRPS14 Gene

Gene Ontology (GO) - Biological Process for MRPS14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS 10938081
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPS14: view

Transcripts for MRPS14 Gene

mRNA/cDNA for MRPS14 Gene

Unigene Clusters for MRPS14 Gene

Mitochondrial ribosomal protein S14:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS14

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS14 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6
SP1: - - - - -
SP2: - -
SP3: - - -
SP4: - -
SP5: - -

Relevant External Links for MRPS14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS14 Gene

mRNA expression in normal human tissues for MRPS14 Gene

Protein differential expression in normal tissues for MRPS14 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.6), Lung (12.0), and Heart (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS14 Gene

SOURCE GeneReport for Unigene cluster for MRPS14 Gene Hs.654858

genes like me logo Genes that share expressions with MRPS14: view

Expression partners for MRPS14 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS14 Gene

Orthologs for MRPS14 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS14 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS14 35
  • 86.72 (n)
  • 90.62 (a)
-- 36
  • 83 (a)
MRPS14 36
  • 90 (a)
(Canis familiaris)
Mammalia MRPS14 35
  • 89.32 (n)
  • 89.84 (a)
-- 36
  • 86 (a)
-- 36
  • 89 (a)
(Mus musculus)
Mammalia Mrps14 35
  • 86.46 (n)
  • 86.72 (a)
Mrps14 16
Mrps14 36
  • 84 (a)
(Pan troglodytes)
Mammalia MRPS14 35
  • 99.48 (n)
  • 100 (a)
MRPS14 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrps14 35
  • 85.68 (n)
  • 85.94 (a)
(Monodelphis domestica)
Mammalia MRPS14 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS14 36
  • 81 (a)
(Gallus gallus)
Aves MRPS14 35
  • 71.16 (n)
  • 78.57 (a)
MRPS14 36
  • 78 (a)
(Anolis carolinensis)
Reptilia MRPS14 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps14 35
  • 69.53 (n)
  • 76.56 (a)
Str.19943 35
(Danio rerio)
Actinopterygii mrps14 35
  • 69.37 (n)
  • 77.48 (a)
mrps14 36
  • 65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2810 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009077 35
  • 51.82 (n)
  • 53.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS14 35
  • 57.6 (n)
  • 64.91 (a)
mRpS14 36
  • 57 (a)
(Caenorhabditis elegans)
Secernentea mrps-14 36
  • 24 (a)
Species with no ortholog for MRPS14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS14 Gene

Gene Tree for MRPS14 (if available)
Gene Tree for MRPS14 (if available)

Paralogs for MRPS14 Gene

No data available for Paralogs for MRPS14 Gene

Variants for MRPS14 Gene

Sequence variations from dbSNP and Humsavar for MRPS14 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3850 -- 175,014,608(+) AAAAT(A/C/G)TTTGC utr-variant-3-prime, nc-transcript-variant
rs733826 -- 175,022,016(+) ACTAG(G/T)GCAAC intron-variant
rs733827 -- 175,022,215(-) atata(A/C)caatg intron-variant
rs984627 -- 175,014,370(-) TTTTA(A/G)TAACA utr-variant-3-prime, nc-transcript-variant
rs1058741 -- 175,014,497(-) GTTTC(A/G)TGTCA utr-variant-3-prime, nc-transcript-variant

Relevant External Links for MRPS14 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPS14 Gene

Disorders for MRPS14 Gene

Relevant External Links for MRPS14

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MRPS14 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MRPS14 Gene

Publications for MRPS14 Gene

  1. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. (PMID: 10938081) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2000) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for MRPS14 Gene

Sources for MRPS14 Gene

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