MRPS14 Gene
protein-coding GIFtS: 46
GCID: GC01M174979
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|
mitochondrial ribosomal protein S14
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Aliases
for MRPS14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein S141 2 | | 28S Ribosomal Protein S14, Mitochondrial2 | | HSMRPS141 2 | | DJ262D12.22 | | MRP-S142 3 | | Mitochondrial 28S Ribosomal Protein S142 | | S14mt2 3 | | |
Export aliases for MRPS14 gene to outside databasesPrevious GC identifers: GC01M172507 GC01M170411 GC01M171562 GC01M172222 GC01M171714 GC01M173248 GC01M146209 |
Summaries
for MRPS14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPS14:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit proteinthat belongs to the ribosomal protein S14P family. Alternative splicing results in multiple transcript variants.(provided by RefSeq, Nov 2010)
|
Genomic Views
for MRPS14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPS14 gene promoter:
HOXA9 HOXA9B IRF-2 AML1a GCNF-2 GATA-1 Meis-1 Meis-1b
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPS14
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS14 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q25.1 Ensembl cytogenetic band: 1q25.1 HGNC cytogenetic band: 1q25.1MRPS14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M174979: view genomic region
(about GC identifiers)
Start:
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174,979,925 bp from pter |
End:
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174,992,561 bp from pter |
Size:
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12,637 bases |
Orientation:
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minus strand |
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Proteins
for MRPS14 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RT14_HUMAN, O60783 (See
protein sequence)Recommended Name: 28S ribosomal protein S14, mitochondrial Size: 128 amino acids; 15139 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinctproteins (By similarity)
Subcellular location: Mitochondrion
Secondary accessions: Q5R358Explore the universe of human proteins at neXtProt for MRPS14: NX_O60783
MRPS14 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_071383.1
ENSEMBL proteins: ENSP00000420714 ENSP00000431220
Human Recombinant Protein Products for MRPS14:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MRPS14 for ontologies About GeneDecksing
MRPS14 Antibody Products:
Assay Products for MRPS14: |
Protein
Domains /
Families
for MRPS14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPS14 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O60783ProtoNet protein and cluster: O60783 1 Blocks protein family: IPB001209 Ribosomal protein S14
UniProtKB/Swiss-Prot: RT14_HUMAN, O60783Similarity: Belongs to the ribosomal protein S14P family |
Function
for MRPS14 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
TAS | 10938081 |
MRPS14 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS14 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS14 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRPS14 (NM_022100) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS14 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS14 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS14 |
|
Pathways & Interactions
for MRPS14 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS14
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/259 Interacting proteins for MRPS14 (O607831, 2, 3 ENSP000004207144) via UniProtKB, MINT, STRING, and/or I2D (see all 259)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
MRPS14 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRPS14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPS14
Search CenterWatch for drugs/clinical trials and news about MRPS14 / RT14
|
Transcripts
for MRPS14 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPS14 gene: NM_022100.2 Unigene Cluster for MRPS14: Mitochondrial ribosomal protein S14 Hs.654858 [show with all ESTs]Unigene Representative Sequence: NR_0376063 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000498253 ENST00000476371(uc009wwr.3 uc001gkk.3) ENST00000367677
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS14 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS14 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRPS14 (NM_022100) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS14 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS14 |
Additional cDNA sequence: AK310915.1 AK311759.1 AL049705.1 BC009788.1 NR_037606.1 18 DOTS entries: DT.214831 DT.112759 DT.97843158 DT.99933826 DT.121344802 DT.100789952 DT.95266618 DT.121344777 DT.95253848 DT.121344964 DT.121345000 DT.91848776 DT.92419420 DT.95232094 DT.100654929 DT.121344702 DT.447539 DT.95356547 24/165 AceView cDNA sequences (see all 165): AA461133 AL711042 AW300675 AA829772 AI033133 W60498 NM_022100 BG254653 T93633 T08865 BM715212 AI086885 BG030440 CB110387 AL049705 BX111081 AA777627 BF589665 AU105746 AI288163 BC038430 BE882322 AL538244 AL119627
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS14 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 |
|---|
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| SP1: | | | | | | | | | - | | - | | | | - | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | - | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MRPS14
|
Expression
for MRPS14 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPS14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAGTGAATT
About this image
See MRPS14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPS14
SOURCE GeneReport for Unigene cluster: Hs.654858
SABiosciences Custom PCR Arrays for MRPS14
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS14
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPS14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS14 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS14 |
Orthologs
for MRPS14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MRPS14 gene from 10/30 species (see all 30) About this table
ENSEMBL Gene Tree for MRPS14 (if available)
TreeFam Gene Tree for MRPS14 (if available) |
Paralogs
for MRPS14 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MRPS14 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPS14 (174979925 - 174992561 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MRPS14: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS14 |
|
Disorders
/ Diseases
for MRPS14 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRPS14 for disorders About MalaCards
MRPS14 for disorders About GeneDecksing
OMIM gene information: 611978
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MRPS14 (1 document)
Export disorders for MRPS14 gene to outside databases
|
Publications
for MRPS14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPS14 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with MRPS14) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. (PubMed id 10938081)1, 2 Koc E.C....Spremulli L.L. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
|
External Searches for MRPS14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPS14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPS14 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPS14 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPS14 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRPS14 gene:
Search GeneIP for patents involving MRPS14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPS14 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRPS14 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPS14 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS14 | | | OriGene Protein Over-expression Lysate for MRPS14 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRPS14 | | OriGene 3'-UTR Clone for MRPS14 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS14 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS14 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | MRPS14 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS14 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for MRPS14 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS14 |
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