MRPS12 Gene
protein-coding GIFtS: 51
GCID: GC19P039422
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mitochondrial ribosomal protein S12
(Previous symbol: RPMS12)
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Aliases
for MRPS12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein S121 2 | | MT-RPS122 3 | | RPSM121 2 3 5 | | S12mt2 3 | | RPMS121 2 3 | | 28S Ribosomal Protein S12, Mitochondrial2 | | RPS121 2 | | MPR-S122 | | MRP-S122 3 | | |
Export aliases for MRPS12 gene to outside databasesPrevious GC identifers: GC19P040033 GC19P039812 GC19P044097 GC19P044113 GC19P035867 |
Summaries
for MRPS12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPS12:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit proteinthat belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal smallsubunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene formitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possiblecandidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been foundfor this gene; all three variants encode the same protein. (provided by RefSeq, Jul 2008)
Gene Wiki entry for MRPS12
|
Genomic Views
for MRPS12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPS12 gene promoter:
MyoD
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPS12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.1-q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.1-q13.2MRPS12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P039422: view genomic region
(about GC identifiers)
Start:
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39,421,348 bp from pter |
End:
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39,423,660 bp from pter |
Size:
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2,313 bases |
Orientation:
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plus strand |
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Proteins
for MRPS12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RT12_HUMAN, O15235 (See
protein sequence)Recommended Name: 28S ribosomal protein S12, mitochondrial precursor Size: 138 amino acids; 15173 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinctproteins
Subcellular location: Mitochondrion
Secondary accessions: Q53X98Explore the universe of human proteins at neXtProt for MRPS12: NX_O15235
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15235
MRPS12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_066930.1 NP_203526.1 NP_203527.1
ENSEMBL proteins: ENSP00000308845 ENSP00000384952 ENSP00000384579
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MRPS12 for ontologies About GeneDecksing
MRPS12 Antibody Products:
Assay Products for MRPS12: |
Protein
Domains /
Families
for MRPS12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPS12 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O15235ProtoNet protein and cluster: O15235 UniProtKB/Swiss-Prot: RT12_HUMAN, O15235Similarity: Belongs to the ribosomal protein S12P family |
Function
for MRPS12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS12 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS12 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): MRPS12 (NM_021107) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS12 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
MRPS12 for ontologies About GeneDecksing
|
Pathways & Interactions
for MRPS12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS12
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/80 Interacting proteins for MRPS12 (O152351, 2, 3 ENSP000003088454) via UniProtKB, MINT, STRING, and/or I2D (see all 80)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006412 | translation |
IEA | -- |
MRPS12 for ontologies About GeneDecksing
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Drugs & Compounds
for MRPS12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
MRPS12 for compounds About GeneDecksing
 Browse Tocris compounds for MRPS12
1 Novoseek chemical compound relationship for MRPS12 gene About this table
Search CenterWatch for drugs/clinical trials and news about MRPS12 / RT12
|
Transcripts
for MRPS12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPS12 gene (3 alternative transcripts): NM_021107.1 NM_033362.3 NM_033363.1 Unigene Cluster for MRPS12: Mitochondrial ribosomal protein S12 Hs.411125 [show with all ESTs]Unigene Representative Sequence: BU1494793 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000308018(uc002okc.3) ENST00000407800(uc002okd.3 uc002oke.3)
ENST00000402029
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS12 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS12 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): MRPS12 (NM_021107) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS12 |
Additional cDNA sequence: BC001617.1 BC006424.1 BC007499.2 CR407609.1 Y11681.1 6 DOTS entries: DT.92441963 DT.109655 DT.95158669 DT.100818428 DT.100818430 DT.95120726 24/293 AceView cDNA sequences (see all 293): NM_033362 BM725156 BM910549 AI373022 CK819397 BU149804 CK819396 BF222138 BM128725 BQ689386 BG686393 AW009469 BU855305 CB151518 BQ676626 AI500320 AA379276 CB126732 BF195572 BF447205 BU625809 BM784661 BM720388 BC001617
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS12 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c |
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| SP1: | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MRPS12
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Expression
for MRPS12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPS12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTCAAGTC
About this image
See MRPS12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPS12
SOURCE GeneReport for Unigene cluster: Hs.411125
SABiosciences Custom PCR Arrays for MRPS12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPS12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS12 |
Orthologs
for MRPS12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MRPS12 gene from 10/31 species (see all 31) About this table
ENSEMBL Gene Tree for MRPS12 (if available)
TreeFam Gene Tree for MRPS12 (if available) |
Paralogs
for MRPS12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MRPS12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPS12 (39421348 - 39423660 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MRPS12: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS12 |
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Disorders
/ Diseases
for MRPS12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRPS12 for disorders About GeneDecksing
OMIM gene information: 603021
OMIM disorders: --
9  diseases for MRPS12: About MalaCardsautosomal dominant nonsyndromic deafness nonsyndromic deafness esophageal carcinoma esophagitis
pneumonia tuberculosis carcinoma malaria
mycobacterium tuberculosis
2 diseases from the University of Copenhagen DISEASES database for MRPS12:Sensorineural hearing loss Nonsyndromic deafness 2 Novoseek disease relationships for MRPS12 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| sterility male |
72.6 |
1 |
10355121 (1) |
| deafness sensorineural |
67 |
1 |
9434165 (1) |
Human Genome Epidemiology (HuGE) Navigator: MRPS12 (1 document)
Export disorders for MRPS12 gene to outside databases
|
Publications
for MRPS12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPS12 gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with MRPS12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of the human mitochondrial ribosomal S12 gene. (PubMed id 9790755)1, 2, 3, 9 Johnson D.F.... Fischel-Ghodsian N. (1998)
- Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus. (PubMed id 9545647)1, 3, 9 Shah Z.H....Jacobs H.T. (1998)
- Metazoan nuclear genes for mitoribosomal protein S12. (PubMed id 9434165)1, 2, 9 Shah Z.H.... Jacobs H.T. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Expression of the gene for mitoribosomal protein S12 is controlled in human cells at the levels of transcription, RNA splicing, and translation. (PubMed id 10542210)1, 9 Mariottini P....Jacobs H.T. (1999)
- NF-Y influences directionality of transcription from the bidirectional Mrps12/Sarsm promoter in both mouse and human cells. (PubMed id 19439209)1, 9 Zanotto E....Jacobs H.T. (2009)
- Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene. (PubMed id 12970870)1, 9 Cui Y.P....Lu S.H. (2003)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
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External Searches for MRPS12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPS12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPS12 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPS12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPS12 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MRPS12 gene:
Search GeneIP for patents involving MRPS12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPS12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRPS12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPS12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS12 | | | OriGene Protein Over-expression Lysate for MRPS12 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRPS12 | | OriGene 3'-UTR Clone for MRPS12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPS12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPS12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS12 |
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 | | | MRPS12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS12 |
|  |  |  | | | | Search ThermoFisher Antibodies for MRPS12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS12 |
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