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MRPS12 Gene

protein-coding   GIFtS: 58
GCID: GC19P039422

Mitochondrial Ribosomal Protein S12


(Previous symbol: RPMS12)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Ribosomal Protein S121 2     S12mt2 3
RPMS121 2 3     28S Ribosomal Protein S12, Mitochondrial2
RPSM122 3 5     MPR-S122
MRP-S122 3     RPS122
MT-RPS122 3     

External Ids:    HGNC: 103801   Entrez Gene: 61832   Ensembl: ENSG000001286267   OMIM: 6030215   UniProtKB: O152353   

Export aliases for MRPS12 gene to outside databases

Previous GC identifers: GC19P040033 GC19P039812 GC19P044097 GC19P044113 GC19P035867


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRPS12 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of
the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics.
The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes
are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5'
UTR have been found for this gene; all three variants encode the same protein. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPS12 Gene:
MRPS12 (mitochondrial ribosomal protein S12) is a protein-coding gene. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRPS12 gene promoter:
         MyoD   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPS12 promoter sequence
   Search Chromatin IP Primers for MRPS12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRPS12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1-q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1-q13.2

MRPS12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPS12 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P039422:  view genomic region     (about GC identifiers)

Start:
39,421,188 bp from pter      End:
39,423,802 bp from pter
Size:
2,615 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RT12_HUMAN, O15235 (See protein sequence)
Recommended Name: 28S ribosomal protein S12, mitochondrial precursor  
Size: 138 amino acids; 15173 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30
distinct proteins
Secondary accessions: Q53X98

Explore the universe of human proteins at neXtProt for MRPS12: NX_O15235

Explore proteomics data for MRPS12 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys122
  • Modification sites at PhosphoSitePlus

  • See MRPS12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_066930.1  NP_203526.1  NP_203527.1  

    ENSEMBL proteins: 
     ENSP00000308845   ENSP00000384952   ENSP00000384579  

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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MRPS12

     
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    antibodies-online proteins for MRPS12 (4 products) 

     
    antibodies-online peptides for MRPS12

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    antibodies-online antibodies for MRPS12 (27 products) 

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    Cloud-Clone Corp. ELISAs for MRPS12
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    antibodies-online kits for MRPS12 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MRPS: Mitochondrial ribosomal proteins / small subunits

    3 InterPro protein domains:
     IPR006032 Ribosomal_S12/S23
     IPR012340 NA-bd_OB-fold
     IPR005679 Ribosomal_S12_bac

    Graphical View of Domain Structure for InterPro Entry O15235

    ProtoNet protein and cluster: O15235

    UniProtKB/Swiss-Prot: RT12_HUMAN, O15235
    Similarity: Belongs to the ribosomal protein S12P family


    Find genes that share domains with MRPS12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IEA--
    GO:0005515protein binding IPI12646258
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with MRPS12           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRPS12
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    miRNA
    Products:
        
    miRTarBase miRNAs that target MRPS12:
    hsa-mir-615-3p (MIRT040468), hsa-mir-124-3p (MIRT022940)

    Block miRNA regulation of human, mouse, rat MRPS12 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MRPS12:
    hsa-miR-922
    SwitchGear 3'UTR luciferase reporter plasmidMRPS12 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat MRPS12

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS12

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RT12_HUMAN, O15235: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol1
    extracellular1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005739mitochondrion ----
    GO:0005761mitochondrial ribosome TAS9545647
    GO:0005840ribosome ----
    GO:0015935small ribosomal subunit IEA--

    Find genes that share ontologies with MRPS12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for MRPS12 About    
    See pathways by source

    SuperPathContained pathways About
    1CFTR translational fidelity class I mutations
    Ribosome0.54


    Find genes that share SuperPaths with MRPS12           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for MRPS12):
        Ribosome

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRPS12
    Interactions:

        Search GeneGlobe Interaction Network for MRPS12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MRPS12 (O152351, 2, 3 ENSP000003088454) via UniProtKB, MINT, STRING, and/or I2D (see all 219)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPINK7P580621, 3, ENSP000002745654EBI-712205,EBI-1182445 I2D: score=4 STRING: ENSP00000274565
    C14orf1Q9UKR52, 3MINT-63099 I2D: score=5 
    UNC119Q134322, 3MINT-63096 I2D: score=5 
    CRMP1Q141942, 3MINT-63097 I2D: score=4 
    LRIF1Q5T3J32, 3MINT-63098 I2D: score=4 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation IEA--

    Find genes that share ontologies with MRPS12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRPS12 (RT12)

    1 Novoseek inferred chemical compound relationship for MRPS12 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nadh 53.4 5 10355121 (1), 1836443 (1), 7545979 (1), 7476853 (1) (see all 5)



    Find genes that share compounds with MRPS12           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MRPS12 gene (3 alternative transcripts): 
    NM_021107.1  NM_033362.3  NM_033363.1  

    Unigene Cluster for MRPS12:

    Mitochondrial ribosomal protein S12
    Hs.411125  [show with all ESTs]
    Unigene Representative Sequence: BU149479
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308018(uc002okc.3) ENST00000598734 ENST00000407800(uc002okd.3 uc002oke.3)
    ENST00000402029
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MRPS12 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate MRPS12:
    hsa-miR-922
    SwitchGear 3'UTR luciferase reporter plasmidMRPS12 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRPS12
      QuantiTect SYBR Green Assays in human, mouse, rat MRPS12
      QuantiFast Probe-based Assays in human, mouse, rat MRPS12

    Additional mRNA sequence: 

    BC001617.1 BC006424.1 BC007499.2 CR407609.1 Y11681.1 

    5 DOTS entries:

    DT.92441963  DT.109655  DT.95158669  DT.100818428  DT.100818430 

    Selected AceView cDNA sequences (see all 293):

    AW009259 AI871147 BX119635 BF222138 NM_033363 BE856125 BE392589 CK819396 
    AI342896 AI813690 BE673266 BM910549 AI160348 BU625809 AI206816 NM_033362 
    AA379276 BM796585 BF195572 BQ053393 BU151564 AI373022 CK819397 CB113841 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS12    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c
    SP1:                    -                           
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for MRPS12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRPS12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTCAAGTC
    MRPS12 Expression
    About this image

    MRPS12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRPS12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.411125
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for MRPS12 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrps121 , 5 mitochondrial ribosomal protein S121, 5 83.09(n)1
    85.51(a)1
      7 (16.91 cM)5
    240301  NM_011885.41  NP_036015.11 
     287396415 
    chicken
    (Gallus gallus)
    Aves MRPS121 mitochondrial ribosomal protein S12 79.17(n)
    80.36(a)
      770472  XM_001233806.3  XP_001233807.1 
    lizard
    (Anolis carolinensis)
    Reptilia MRPS126
    mitochondrial ribosomal protein S12
    68(a)
    1 ↔ 1
    GL343907.1(103736-104167)
    African clawed frog
    (Xenopus laevis)
    Amphibia mrps12-prov2 mitochondrial ribosomal protein S12 76.73(n)    BC054176.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.182182 Danio rerio, clone IMAGE6033814, mRNA 74.43(n)    BC050176.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta tko1 , 3 protein biosynthesis structural
    constituent of more3
    technical knockout1
    63(a)3
    59.74(n)1
    60(a)1
      1 3A33
    312281  NM_001258561.11  NP_001245490.11 
    worm
    (Caenorhabditis elegans)
    Secernentea mrps-121 mrps-12 51.89(n)
    57.73(a)
      180368  NM_075622.4  NP_508023.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MRPS12(YNR036C)4
    MRPS121
    Mitochondrial protein; may interact with ribosomes more4
    MRPS121
    49.85(n)1
    56.64(a)1
      14(694822-694361)4
    8557721, 4  NP_014434.11, 4 
    rice
    (Oryza sativa)
    Liliopsida Os04g02347501 Os04g0234750 48.75(n)
    53.75(a)
      9268225  NM_001186879.1  NP_001173808.1 


    ENSEMBL Gene Tree for MRPS12 (if available)
    TreeFam Gene Tree for MRPS12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MRPS12 (see all 148)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs790810551,2
    C,F--39569053(+) TACTCT/GTCTTC 1 -- us2k11Minor allele frequency- G:0.05NA 120
    rs803416371,2
    C--39569168(+) CAGATA/TATAAT 1 -- us2k10--------
    rs1877482071,2
    --39569181(+) GTATAC/TCTGTC 1 -- us2k10--------
    rs1496575661,2
    C--39569193(+) CTATG-/AATTTG 1 -- us2k10--------
    rs1452678551,2
    --39569433(+) TGCCTA/GTAATC 3 -- us2k10--------
    rs1476117211,2
    --39569855(+) TACCAC/GTGTAC 3 -- us2k10--------
    rs118825881,2
    C,F,H--39569893(+) CAACAC/TCCTAT 3 -- us2k19Minor allele frequency- T:0.25NA WA CSA EA 370
    rs349857121,2
    C--39569901(+) ATCTC-/AAAAAA 3 -- us2k10--------
    rs785285101,2
    --39569921(+) AAAAAC/GTGGAT 3 -- us2k10--------
    rs769825521,2
    F--39569923(+) AAAGTG/AGATTC 3 -- us2k12Minor allele frequency- A:0.09CSA WA 120

    HapMap Linkage Disequilibrium report for MRPS12 (39421188 - 39423802 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for MRPS12: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRPS12
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPS12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603021    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for MRPS12:
    Sensorineural hearing loss     Nonsyndromic deafness

    Find genes that share disorders with MRPS12           About GenesLikeMe

    2 Novoseek inferred disease relationships for MRPS12 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sterility male 72.6 1 10355121 (1)
    deafness sensorineural 67 1 9434165 (1)

    Genetic Association Database (GAD): MRPS12
    Human Genome Epidemiology (HuGE) Navigator: MRPS12 (1 document)

    Export disorders for MRPS12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRPS12 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with MRPS12)
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    1. Characterization of the human mitochondrial ribosomal S12 gene. (PubMed id 9790755)1, 2, 3, 9 Johnson D.F.... Fischel-Ghodsian N. (Genomics 1998)
    2. Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus. (PubMed id 9545647)1, 3, 9 Shah Z.H....Jacobs H.T. (Genomics 1998)
    3. Metazoan nuclear genes for mitoribosomal protein S12. (PubMed id 9434165)1, 2, 9 Shah Z.H.... Jacobs H.T. (Gene 1997)
    4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Expression of the gene for mitoribosomal protein S12 is controlled in human cells at the levels of transcription, RNA splicing, and translation. (PubMed id 10542210)1, 9 Mariottini P....Jacobs H.T. (J. Biol. Chem. 1999)
    7. NF-Y influences directionality of transcription from the bidirectional Mrps12/Sarsm promoter in both mouse and human cells. (PubMed id 19439209)1, 9 Zanotto E....Jacobs H.T. (Biochim. Biophys. Acta 2009)
    8. Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene. (PubMed id 12970870)1, 9 Cui Y.P....Lu S.H. (World J. Gastroenterol. 2003)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6183 HGNC: 10380 AceView: MRPS12 Ensembl:ENSG00000128626 euGenes: HUgn6183
    ECgene: MRPS12 Kegg: 6183 H-InvDB: MRPS12

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRPS12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MRPS12 gene:
    Search GeneIP for patents involving MRPS12

    GeneCards and IP:
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