Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPS12 Gene

Aliases for MRPS12 Gene

  • Mitochondrial Ribosomal Protein S12 2 3 5
  • MT-RPS12 3 4
  • MRP-S12 3 4
  • RPMS12 3 4
  • RPSM12 3 4
  • S12mt 3 4
  • MPR-S12 3
  • RPS12 3

External Ids for MRPS12 Gene

Previous HGNC Symbols for MRPS12 Gene

  • RPMS12

Previous GeneCards Identifiers for MRPS12 Gene

  • GC19P040033
  • GC19P039812
  • GC19P044097
  • GC19P044113
  • GC19P039422
  • GC19P035867

Summaries for MRPS12 Gene

Entrez Gene Summary for MRPS12 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS12 Gene

MRPS12 (Mitochondrial Ribosomal Protein S12) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPS12 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS12 Gene

Genomics for MRPS12 Gene

Regulatory Elements for MRPS12 Gene

Enhancers for MRPS12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPS12 on UCSC Golden Path with GeneCards custom track

Promoters for MRPS12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPS12 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MRPS12 gene promoter:

Genomic Location for MRPS12 Gene

38,930,548 bp from pter
38,933,162 bp from pter
2,615 bases
Plus strand

Genomic View for MRPS12 Gene

Genes around MRPS12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS12 Gene

Proteins for MRPS12 Gene

  • Protein details for MRPS12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S12, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q53X98

    Protein attributes for MRPS12 Gene

    138 amino acids
    Molecular mass:
    15173 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for MRPS12 Gene

neXtProt entry for MRPS12 Gene

Proteomics data for MRPS12 Gene at MOPED

Post-translational modifications for MRPS12 Gene

  • Ubiquitination at Lys 122
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS12 Gene

No data available for DME Specific Peptides for MRPS12 Gene

Domains & Families for MRPS12 Gene

Gene Families for MRPS12 Gene

Protein Domains for MRPS12 Gene

Suggested Antigen Peptide Sequences for MRPS12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S12P family.
  • Belongs to the ribosomal protein S12P family.
genes like me logo Genes that share domains with MRPS12: view

Function for MRPS12 Gene

genes like me logo Genes that share phenotypes with MRPS12: view

Animal Model Products

miRNA for MRPS12 Gene

miRTarBase miRNAs that target MRPS12

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS12 Gene

Localization for MRPS12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS12 Gene


Subcellular locations from

Jensen Localization Image for MRPS12 Gene COMPARTMENTS Subcellular localization image for MRPS12 gene
Compartment Confidence
mitochondrion 5
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRPS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPS12: view

Pathways & Interactions for MRPS12 Gene

genes like me logo Genes that share pathways with MRPS12: view

Gene Ontology (GO) - Biological Process for MRPS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,IBA --
genes like me logo Genes that share ontologies with MRPS12: view

No data available for SIGNOR curated interactions for MRPS12 Gene

Drugs & Compounds for MRPS12 Gene

(1) Drugs for MRPS12 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MRPS12: view

Transcripts for MRPS12 Gene

Unigene Clusters for MRPS12 Gene

Mitochondrial ribosomal protein S12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS12 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c
SP1: -

Relevant External Links for MRPS12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS12 Gene

mRNA expression in normal human tissues for MRPS12 Gene

Protein differential expression in normal tissues from HIPED for MRPS12 Gene

This gene is overexpressed in Breast (19.5), Lung (10.6), Pancreas (10.0), and Peripheral blood mononuclear cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS12 Gene

SOURCE GeneReport for Unigene cluster for MRPS12 Gene Hs.411125

genes like me logo Genes that share expression patterns with MRPS12: view

Protein tissue co-expression partners for MRPS12 Gene

- Elite partner

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS12 Gene

Orthologs for MRPS12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRPS12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS12 35
  • 84.78 (n)
  • 83.33 (a)
MRPS12 36
  • 83 (a)
(Canis familiaris)
Mammalia MRPS12 35
  • 83.57 (n)
  • 82.61 (a)
MRPS12 36
  • 82 (a)
(Mus musculus)
Mammalia Mrps12 35
  • 83.09 (n)
  • 85.51 (a)
Mrps12 16
Mrps12 36
  • 85 (a)
(Pan troglodytes)
Mammalia MRPS12 35
  • 98.55 (n)
  • 99.28 (a)
MRPS12 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mrps12 35
  • 83.82 (n)
  • 86.96 (a)
(Monodelphis domestica)
Mammalia MRPS12 36
  • 65 (a)
(Gallus gallus)
Aves MRPS12 35
  • 79.17 (n)
  • 80.36 (a)
MRPS12 36
  • 44 (a)
(Anolis carolinensis)
Reptilia MRPS12 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps12 35
  • 73.03 (n)
  • 80.91 (a)
Str.8460 35
African clawed frog
(Xenopus laevis)
Amphibia mrps12-prov 35
(Danio rerio)
Actinopterygii Dr.18218 35
si:dkey-17e16.10 35
  • 67.54 (n)
  • 72.17 (a)
MRPS12 (1 of 2) 36
  • 66 (a)
MRPS12 (2 of 2) 36
  • 60 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13724 35
fruit fly
(Drosophila melanogaster)
Insecta tko 37
  • 63 (a)
tko 35
  • 59.74 (n)
  • 60 (a)
tko 36
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013102 35
  • 61.33 (n)
  • 62.4 (a)
(Caenorhabditis elegans)
Secernentea mrps-12 35
  • 51.89 (n)
  • 57.73 (a)
mrps-12 36
  • 38 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL222W 35
  • 57.62 (n)
  • 51.94 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F07007g 35
  • 48.06 (n)
  • 51.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPS12 35
  • 49.85 (n)
  • 56.64 (a)
MRPS12 36
  • 41 (a)
MRPS12 38
(Oryza sativa)
Liliopsida Os04g0234750 35
  • 48.75 (n)
  • 53.75 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06542 35
  • 52.92 (n)
  • 53.75 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC4F8.06 35
  • 45.57 (n)
  • 53.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
Species with no ortholog for MRPS12:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS12 Gene

Gene Tree for MRPS12 (if available)
Gene Tree for MRPS12 (if available)

Paralogs for MRPS12 Gene

No data available for Paralogs for MRPS12 Gene

Variants for MRPS12 Gene

Sequence variations from dbSNP and Humsavar for MRPS12 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_051820 -
rs1808661 -- 38,933,313(+) GGATT(A/G)TAGGC downstream-variant-500B
rs1808662 -- 38,933,469(+) ACGCC(C/T)GGCAG downstream-variant-500B
rs76304301 -- 38,933,184(+) TTTTT(C/T)TTTTT downstream-variant-500B
rs78101882 -- 38,933,182(+) TCTTT(C/T)TTTTT downstream-variant-500B

Variation tolerance for MRPS12 Gene

Residual Variation Intolerance Score: 48.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.34% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MRPS12 Gene

Disorders for MRPS12 Gene

Relevant External Links for MRPS12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPS12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS12 Gene

Publications for MRPS12 Gene

  1. Characterization of the human mitochondrial ribosomal S12 gene. (PMID: 9790755) Johnson D.F. … Fischel-Ghodsian N. (Genomics 1998) 2 3 4 23 67
  2. Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus. (PMID: 9545647) Shah Z.H. … Jacobs H.T. (Genomics 1998) 2 3 23
  3. NF-Y influences directionality of transcription from the bidirectional Mrps12/Sarsm promoter in both mouse and human cells. (PMID: 19439209) Zanotto E. … Jacobs H.T. (Biochim. Biophys. Acta 2009) 3 23
  4. Using yeast two-hybrid system to identify ECRG2 associated proteins and their possible interactions with ECRG2 gene. (PMID: 12970870) Cui Y.P. … Lu S.H. (World J. Gastroenterol. 2003) 3 23
  5. Expression of the gene for mitoribosomal protein S12 is controlled in human cells at the levels of transcription, RNA splicing, and translation. (PMID: 10542210) Mariottini P. … Jacobs H.T. (J. Biol. Chem. 1999) 3 23

Products for MRPS12 Gene

Sources for MRPS12 Gene