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Aliases for MRPS12 Gene

Aliases for MRPS12 Gene

  • Mitochondrial Ribosomal Protein S12 2 3
  • MT-RPS12 3 4
  • MRP-S12 3 4
  • RPMS12 3 4
  • RPSM12 3 4
  • S12mt 3 4
  • MPR-S12 3
  • RPS12 3

External Ids for MRPS12 Gene

Previous HGNC Symbols for MRPS12 Gene

  • RPMS12

Previous GeneCards Identifiers for MRPS12 Gene

  • GC19P040033
  • GC19P039812
  • GC19P044097
  • GC19P044113
  • GC19P039422
  • GC19P035867

Summaries for MRPS12 Gene

Entrez Gene Summary for MRPS12 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S12P family. The encoded protein is a key component of the ribosomal small subunit and controls the decoding fidelity and susceptibility to aminoglycoside antibiotics. The gene for mitochondrial seryl-tRNA synthetase is located upstream and adjacent to this gene, and both genes are possible candidates for the autosomal dominant deafness gene (DFNA4). Splice variants that differ in the 5' UTR have been found for this gene; all three variants encode the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS12 Gene

MRPS12 (Mitochondrial Ribosomal Protein S12) is a Protein Coding gene. Among its related pathways are Infectious disease and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for MRPS12 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS12 Gene

Genomics for MRPS12 Gene

Regulatory Elements for MRPS12 Gene

Transcription factor binding sites by QIAGEN in the MRPS12 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPS12 Gene

Chromosome:
19
Start:
38,930,548 bp from pter
End:
38,933,162 bp from pter
Size:
2,615 bases
Orientation:
Plus strand

Genomic View for MRPS12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS12 Gene

Proteins for MRPS12 Gene

  • Protein details for MRPS12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15235-RT12_HUMAN
    Recommended name:
    28S ribosomal protein S12, mitochondrial
    Protein Accession:
    O15235
    Secondary Accessions:
    • Q53X98

    Protein attributes for MRPS12 Gene

    Size:
    138 amino acids
    Molecular mass:
    15173 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins

    Three dimensional structures from OCA and Proteopedia for MRPS12 Gene

neXtProt entry for MRPS12 Gene

Proteomics data for MRPS12 Gene at MOPED

Post-translational modifications for MRPS12 Gene

  • Ubiquitination at Lys 122
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPS12 Gene

Antibody Products

No data available for DME Specific Peptides for MRPS12 Gene

Domains & Families for MRPS12 Gene

Gene Families for MRPS12 Gene

Protein Domains for MRPS12 Gene

Suggested Antigen Peptide Sequences for MRPS12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15235

UniProtKB/Swiss-Prot:

RT12_HUMAN :
  • Belongs to the ribosomal protein S12P family.
Family:
  • Belongs to the ribosomal protein S12P family.
genes like me logo Genes that share domains with MRPS12: view

Function for MRPS12 Gene

Gene Ontology (GO) - Molecular Function for MRPS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome ISS 11402041
GO:0005515 protein binding IPI 12646258
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MRPS12: view

Phenotypes for MRPS12 Gene

genes like me logo Genes that share phenotypes with MRPS12: view

Animal Model Products

miRNA for MRPS12 Gene

miRTarBase miRNAs that target MRPS12

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS12

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS12 Gene

Localization for MRPS12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS12 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS12 Gene COMPARTMENTS Subcellular localization image for MRPS12 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for MRPS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome TAS 9545647
GO:0005763 mitochondrial small ribosomal subunit ISS 11402041
genes like me logo Genes that share ontologies with MRPS12: view

Pathways & Interactions for MRPS12 Gene

SuperPathways for MRPS12 Gene

Superpath Contained pathways
1 Viral mRNA Translation
.60
2 Mitochondrial translation
3 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
4 Influenza Viral RNA Transcription and Replication
5 Infectious disease
.53
genes like me logo Genes that share pathways with MRPS12: view

Pathways by source for MRPS12 Gene

1 KEGG pathway for MRPS12 Gene
1 GeneGo (Thomson Reuters) pathway for MRPS12 Gene

Gene Ontology (GO) - Biological Process for MRPS12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IBA --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPS12: view

No data available for SIGNOR curated interactions for MRPS12 Gene

Drugs & Compounds for MRPS12 Gene

(1) Drugs for MRPS12 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
NADH Nutra 0
genes like me logo Genes that share compounds with MRPS12: view

Transcripts for MRPS12 Gene

Unigene Clusters for MRPS12 Gene

Mitochondrial ribosomal protein S12:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS12 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c
SP1: -
SP2:
SP3:

Relevant External Links for MRPS12 Gene

GeneLoc Exon Structure for
MRPS12
ECgene alternative splicing isoforms for
MRPS12

Expression for MRPS12 Gene

mRNA expression in normal human tissues for MRPS12 Gene

Protein differential expression in normal tissues from HIPED for MRPS12 Gene

This gene is overexpressed in Breast (19.5), Lung (10.6), Pancreas (10.0), and Peripheral blood mononuclear cells (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS12 Gene



SOURCE GeneReport for Unigene cluster for MRPS12 Gene Hs.411125

genes like me logo Genes that share expression patterns with MRPS12: view

Protein tissue co-expression partners for MRPS12 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS12 Gene

Orthologs for MRPS12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRPS12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPS12 35
  • 84.78 (n)
  • 83.33 (a)
MRPS12 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS12 35
  • 83.57 (n)
  • 82.61 (a)
MRPS12 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrps12 35
  • 83.09 (n)
  • 85.51 (a)
Mrps12 16
Mrps12 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPS12 35
  • 98.55 (n)
  • 99.28 (a)
MRPS12 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps12 35
  • 83.82 (n)
  • 86.96 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPS12 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS12 35
  • 79.17 (n)
  • 80.36 (a)
MRPS12 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPS12 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps12 35
  • 73.03 (n)
  • 80.91 (a)
Str.8460 35
African clawed frog
(Xenopus laevis)
Amphibia mrps12-prov 35
zebrafish
(Danio rerio)
Actinopterygii Dr.18218 35
si:dkey-17e16.10 35
  • 67.54 (n)
  • 72.17 (a)
MRPS12 (1 of 2) 36
  • 66 (a)
OneToMany
MRPS12 (2 of 2) 36
  • 60 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13724 35
fruit fly
(Drosophila melanogaster)
Insecta tko 37
  • 63 (a)
tko 35
  • 59.74 (n)
  • 60 (a)
tko 36
  • 47 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013102 35
  • 61.33 (n)
  • 62.4 (a)
worm
(Caenorhabditis elegans)
Secernentea mrps-12 35
  • 51.89 (n)
  • 57.73 (a)
mrps-12 36
  • 38 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL222W 35
  • 57.62 (n)
  • 51.94 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F07007g 35
  • 48.06 (n)
  • 51.94 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPS12 35
  • 49.85 (n)
  • 56.64 (a)
MRPS12 36
  • 41 (a)
OneToOne
MRPS12 38
rice
(Oryza sativa)
Liliopsida Os04g0234750 35
  • 48.75 (n)
  • 53.75 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06542 35
  • 52.92 (n)
  • 53.75 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC4F8.06 35
  • 45.57 (n)
  • 53.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToOne
Species with no ortholog for MRPS12:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS12 Gene

ENSEMBL:
Gene Tree for MRPS12 (if available)
TreeFam:
Gene Tree for MRPS12 (if available)

Paralogs for MRPS12 Gene

No data available for Paralogs for MRPS12 Gene

Variants for MRPS12 Gene

Sequence variations from dbSNP and Humsavar for MRPS12 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1808661 -- 38,933,313(+) GGATT(A/G)TAGGC downstream-variant-500B
rs1808662 -- 38,933,469(+) ACGCC(C/T)GGCAG downstream-variant-500B
rs5828022 -- 38,933,181(+) TCTTT(-/C)TTTTT downstream-variant-500B
rs76304301 -- 38,933,184(+) TTTTT(C/T)TTTTT downstream-variant-500B
rs78101882 -- 38,933,182(+) TCTTT(C/T)TTTTT downstream-variant-500B

Variation tolerance for MRPS12 Gene

Residual Variation Intolerance Score: 48.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS12 Gene

HapMap Linkage Disequilibrium report
MRPS12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPS12 Gene

Disorders for MRPS12 Gene

Relevant External Links for MRPS12

Genetic Association Database (GAD)
MRPS12
Human Genome Epidemiology (HuGE) Navigator
MRPS12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS12
genes like me logo Genes that share disorders with MRPS12: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS12 Gene

Publications for MRPS12 Gene

  1. Chromosomal locations of three human nuclear genes (RPSM12, TUFM, and AFG3L1) specifying putative components of the mitochondrial gene expression apparatus. (PMID: 9545647) Shah Z.H. … Jacobs H.T. (Genomics 1998) 2 23 67
  2. Characterization of the human mitochondrial ribosomal S12 gene. (PMID: 9790755) Johnson D.F. … Fischel-Ghodsian N. (Genomics 1998) 2 23 67
  3. NF-Y influences directionality of transcription from the bidirectional Mrps12/Sarsm promoter in both mouse and human cells. (PMID: 19439209) Zanotto E. … Jacobs H.T. (Biochim. Biophys. Acta 2009) 23 67
  4. Modulation of Mrps12/Sarsm promoter activity in response to mitochondrial stress. (PMID: 18755224) Zanotto E. … Jacobs H.T. (Biochim. Biophys. Acta 2008) 23 67
  5. The bidirectional promoter of two genes for the mitochondrial translational apparatus in mouse is regulated by an array of CCAAT boxes interacting with the transcription factor NF-Y. (PMID: 17179180) Zanotto E. … Jacobs H.T. (Nucleic Acids Res. 2007) 23 67

Products for MRPS12 Gene

Sources for MRPS12 Gene

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