Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



MRPS11 Gene

protein-coding   GIFtS: 59
GCID: GC15P089010

Mitochondrial Ribosomal Protein S11

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Mitochondrial Ribosomal Protein S111 2     S11mt2 3
Cervical Cancer Proto-Oncogene 2 Protein2 3     Cervical Cancer Proto-Oncogene 21
HCC-22 3     28S Ribosomal Protein S11, Mitochondrial2
MRP-S112 3     RPMS113

External Ids:    HGNC: 140501   Entrez Gene: 649632   Ensembl: ENSG000001819917   OMIM: 6119775   UniProtKB: P829123   

Export aliases for MRPS11 gene to outside databases

Previous GC identifers: GC15P085107 GC15P082295 GC15P086597 GC15P086740 GC15P086811 GC15P065122


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for MRPS11 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members.
A pseudogene corresponding to this gene is found on chromosome 20. Sequence analysis identified two transcript
variants that encode different protein isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for MRPS11 Gene:
MRPS11 (mitochondrial ribosomal protein S11) is a protein-coding gene. Diseases associated with MRPS11 include cervical cancer, and cervicitis. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the MRPS11 gene promoter:
         p53   Brachyury   SREBP-1c   STAT5A   GATA-1   SREBP-1b   S8   SREBP-1a   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPS11 promoter sequence
   Search Chromatin IP Primers for MRPS11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRPS11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25   Ensembl cytogenetic band:  15q25.3   HGNC cytogenetic band: 15q25

MRPS11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPS11 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P089010:  view genomic region     (about GC identifiers)

Start:
89,010,684 bp from pter      End:
89,022,222 bp from pter
Size:
11,539 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: RT11_HUMAN, P82912 (See protein sequence)
Recommended Name: 28S ribosomal protein S11, mitochondrial precursor  
Size: 194 amino acids; 20616 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30
distinct proteins
Secondary accessions: B2RD52 Q969D7 Q96GI3 Q9BYC3
Alternative splicing: 3 isoforms:  P82912-1   P82912-2   P82912-3   

Explore the universe of human proteins at neXtProt for MRPS11: NX_P82912

Explore proteomics data for MRPS11 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys59, Lys79, Lys121, Lys122, Lys152
  • Modification sites at PhosphoSitePlus

  • See MRPS11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_073750.2  NP_789775.1  

    ENSEMBL proteins: 
     ENSP00000453116   ENSP00000317376   ENSP00000318054  

    MRPS11 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for MRPS11
    OriGene Protein Over-expression Lysate for MRPS11
    OriGene MassSpec for MRPS11
    OriGene Custom Protein Services for MRPS11
    GenScript Custom Purified and Recombinant Proteins Services for MRPS11
    Novus Biologicals MRPS11 Protein
    Novus Biologicals MRPS11 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MRPS11

    MRPS11 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for MRPS11
    OriGene Custom Antibody Services for MRPS11
    Novus Biologicals MRPS11 Antibodies
    Abcam antibodies for MRPS11
    Cloud-Clone Corp. Antibodies for MRPS11
    Search ThermoFisher Antibodies for MRPS11
    LSBio Antibodies in human, mouse, rat for MRPS11

    MRPS11 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for MRPS11
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MRPS11
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MRPS11
    Cloud-Clone Corp. CLIAs for MRPS11


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    MRPS: Mitochondrial ribosomal proteins / small subunits

    2 InterPro protein domains:
     IPR018102 Ribosomal_S11_CS
     IPR001971 Ribosomal_S11

    Graphical View of Domain Structure for InterPro Entry P82912

    ProtoNet protein and cluster: P82912

    1 Blocks protein domain: IPB001971 Ribosomal protein S11

    UniProtKB/Swiss-Prot: RT11_HUMAN, P82912
    Similarity: Belongs to the ribosomal protein S11P family


    MRPS11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    MRPS11 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for MRPS11:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRPS11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MRPS11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MRPS11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MRPS11

    miRNA
    Products:
        
    miRTarBase miRNAs that target MRPS11:
    hsa-mir-92a-1-5p (MIRT038922), hsa-let-7b-5p (MIRT051908), hsa-mir-15b-5p (MIRT046384), hsa-mir-124-3p (MIRT022877)

    Block miRNA regulation of human, mouse, rat MRPS11 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MRPS11:
    hsa-miR-525-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidMRPS11 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MRPS11
    Predesigned siRNA for gene silencing in human, mouse, rat MRPS11

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for MRPS11

    Clone
    Products:
         
    OriGene clones in human, mouse for MRPS11 (see all 12)
    OriGene ORF clones in mouse, rat for MRPS11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MRPS11 (NM_022839)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRPS11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS11

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for MRPS11
    Browse ESI BIO Cell Lines and PureStem Progenitors for MRPS11 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    RT11_HUMAN, P82912: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol1
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0005763mitochondrial small ribosomal subunit ISS--
    GO:0005840ribosome ----

    MRPS11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for MRPS11 About    
    See pathways by source

    SuperPathContained pathways About
    1CFTR translational fidelity class I mutations
    Ribosome0.54

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for MRPS11):
        Ribosome


    MRPS11 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRPS11
    Interactions:

        Search GeneGlobe Interaction Network for MRPS11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MRPS11 (P829122, 3 ENSP000003173764) via UniProtKB, MINT, STRING, and/or I2D (see all 450)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    DYNC1H1Q142043, ENSP000003489654I2D: score=1 STRING: ENSP00000348965
    MAP1LC3AQ9H4923, ENSP000003639704I2D: score=1 STRING: ENSP00000363970
    NLKQ9UBE83, ENSP000003846254I2D: score=1 STRING: ENSP00000384625
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation IEA--
    GO:0042769DNA damage response, detection of DNA damage NAS15300802

    MRPS11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRPS11 (RT11)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for MRPS11 gene (2 alternative transcripts): 
    NM_022839.3  NM_176805.2  

    Unigene Cluster for MRPS11:

    Mitochondrial ribosomal protein S11
    Hs.111286  [show with all ESTs]
    Unigene Representative Sequence: AK027059
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000560708 ENST00000325844(uc002bml.3 uc002bmm.3 uc002bmn.3)
    ENST00000559125 ENST00000557974 ENST00000559323(uc010bnj.3) ENST00000560850
    ENST00000353598 ENST00000558406 ENST00000559557 ENST00000558548 ENST00000561262

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MRPS11 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate MRPS11:
    hsa-miR-525-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidMRPS11 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MRPS11
    Predesigned siRNA for gene silencing in human, mouse, rat MRPS11
    Clone
    Products:
         
    OriGene clones in human, mouse for MRPS11 (see all 12)
    OriGene ORF clones in mouse, rat for MRPS11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): MRPS11 (NM_022839)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRPS11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS11
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for MRPS11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRPS11
      QuantiTect SYBR Green Assays in human, mouse, rat MRPS11
      QuantiFast Probe-based Assays in human, mouse, rat MRPS11

    Additional mRNA sequence: 

    AB049944.1 AK026165.1 AK027059.1 AK222933.1 AK223152.1 AK315407.1 AL110094.1 BC009451.1 
    BC012489.1 BC032378.1 

    14 DOTS entries:

    DT.100753201  DT.317377  DT.100790407  DT.97848415  DT.100790409  DT.75192684  DT.91750888  DT.95194578 
    DT.95194586  DT.91750890  DT.95093075  DT.95291154  DT.97801466  DT.95316579 

    Selected AceView cDNA sequences (see all 253):

    BM979790 NM_176805 AI348664 F20720 NM_022839 BI258226 BI259243 BM771428 
    BE407132 AA355412 BQ222332 BM771455 BM770730 BQ684284 CB111811 BQ020942 
    BG250651 BU731060 AW246715 CF528500 BE888948 BU156947 BM770070 BQ059220 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for MRPS11 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f
    SP1:                                            -     -     -     -                 -                       -                                       
    SP2:                                            -     -     -     -                 -                       -                                       
    SP3:                                            -     -     -     -     -           -                       -                                       
    SP4:                                            -     -     -     -                 -     -                 -                                       
    SP5:                                            -     -     -     -     -     -     -                       -                                       


    ECgene alternative splicing isoforms for MRPS11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    MRPS11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCGGCCTGG
    MRPS11 Expression
    About this image


    MRPS11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    MRPS11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRPS11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.111286
        Custom PCR Arrays for MRPS11
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for MRPS11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRPS11
    QuantiTect SYBR Green Assays in human, mouse, rat MRPS11
    QuantiFast Probe-based Assays in human, mouse, rat MRPS11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for MRPS11 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrps111 , 5 mitochondrial ribosomal protein S111, 5 79.41(n)1
    72.77(a)1
      7 (44.80 cM)5
    679941  NM_026498.21  NP_080774.21 
     787831195 
    chicken
    (Gallus gallus)
    Aves MRPS111 mitochondrial ribosomal protein S11 67.74(n)
    66.67(a)
      415498  NM_001005821.1  NP_001005821.1 
    lizard
    (Anolis carolinensis)
    Reptilia MRPS116
    mitochondrial ribosomal protein S11
    63(a)
    1 ↔ 1
    GL343389.1(123218-145281)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.65982 Xenopus laevis transcribed sequence with moderate similarity more 75.3(n)    CB591449.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.157522 Transcribed sequence with weak similarity to protein more 73.99(n)    BM529889.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpS116
    mitochondrial ribosomal protein S11
    35(a)
    1 ↔ 1
    3R(12898453-12899517)
    worm
    (Caenorhabditis elegans)
    Secernentea mrps-116
    Protein MRPS-11 (mrps-11) mRNA, complete cds
    31(a)
    1 ↔ 1
    V(12493240-12494622) WBGene00012244


    ENSEMBL Gene Tree for MRPS11 (if available)
    TreeFam Gene Tree for MRPS11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for MRPS11 gene

    MRPS11 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for MRPS11
    PGOHUM00000247460


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for MRPS11 (see all 234)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1828428031,2
    --89012634(+) CAAACA/CGACAA 2 -- int10--------
    rs800070651,2
    --89012720(+) ATAACA/GGTTGG 2 -- int10--------
    rs620243351,2
    C,F--89012747(+) TCAAGC/GAGGCC 2 -- int14Minor allele frequency- G:0.08NA EA 244
    rs1429836771,2
    C--89012756(+) CTGCA-/TTAGCC 2 -- int10--------
    rs1855467431,2
    --89012819(+) ATGAAA/GTGGGA 2 -- int10--------
    rs779160731,2
    F--89012830(+) GGCCAA/GTGGAA 2 -- int10--------
    rs1178648261,2
    F--89012928(+) AAGAAT/AGGAAG 2 -- int11Minor allele frequency- A:0.01NA 120
    rs1900039111,2
    --89012955(+) AAGCAG/TTTAGA 2 -- int10--------
    rs1420151921,2
    --89012978(+) TAATCC/TAGACA 2 -- int10--------
    rs284084591,2
    C,F--89013031(+) ATTATG/AAATGG 2 -- int16Minor allele frequency- A:0.30NA WA CSA 128

    HapMap Linkage Disequilibrium report for MRPS11 (89010684 - 89022222 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MRPS11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv904476CNV Gain21882294
    nsv833085CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRPS11
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPS11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611977    OMIM disorders: --

    4 diseases for MRPS11:    
    About MalaCards
    cervical cancer    cervicitis    pneumonia    tuberculosis


    MRPS11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): MRPS11
    Human Genome Epidemiology (HuGE) Navigator: MRPS11 (1 document)

    Export disorders for MRPS11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for MRPS11 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with MRPS11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041)1, 2, 3 Suzuki T....Watanabe K. (J. Biol. Chem. 2001)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2 Koc E.C.... Spremulli L.L. (J. Biol. Chem. 2001)
    6. ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA. (PubMed id 15300802)1, 9 Ishiguchi H....Kohno K. (Int. J. Cancer 2004)
    7. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 64963 HGNC: 14050 AceView: MRPS11 Ensembl:ENSG00000181991 euGenes: HUgn64963
    ECgene: MRPS11 Kegg: 64963 H-InvDB: MRPS11

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for MRPS11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for MRPS11 gene:
    Search GeneIP for patents involving MRPS11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for MRPS11   OriGene RNAi products in human, mouse, rat for MRPS11  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for MRPS11  
     OriGene MassSpec something-or-other for MRPS11   OriGene clones in human, mouse for MRPS11  
     OriGene qSTAR qPCR primer pairs in human, mouse for MRPS11   OriGene Purified Protein for MRPS11  
     OriGene ORF clones in mouse, rat for MRPS11   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for MRPS11   OriGene Custom Protein Services for MRPS11  

     
     
     Block miRNA regulation of human, mouse, rat MRPS11 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing MRPS11
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRPS11 Predesigned siRNA for gene silencing in human, mouse, rat MRPS11
     QuantiFast Probe-based Assays in human, mouse, rat MRPS11 QuantiTect SYBR Green Assays in human, mouse, rat MRPS11
     Custom PCR Arrays for MRPS11 Search Chromatin IP Primers for MRPS11
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRPS11  Search GeneGlobe Interaction Network for MRPS11
     Regulatory tfbs in MRPS11 promoter
     GenScript Custom Purified and Recombinant Proteins Services for MRPS11 GenScript cDNA clones with any tag delivered in your preferred vector for MRPS11
     GenScript Custom Assay Services for MRPS11 GenScript Custom overexpressing Cell Line Services for MRPS11
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for MRPS11 (RT11)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     MRPS11 antibodies
     MRPS11 proteins
     MRPS11 lysates
     Antibodies for MRPS11
     See all of Abcam's Antibodies, Kits and Proteins for MRPS11
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for MRPS11
     Antibodies for MRPS11
     ELISAs for MRPS11
     CLIAs for MRPS11



     Browse ESI BIO Cell Lines and PureStem Progenitors for MRPS11
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS11
     SwitchGear 3'UTR luciferase reporter plasmids for MRPS11
     SwitchGear Promoter luciferase reporter plasmids for MRPS11
     Search ThermoFisher Antibodies for MRPS11
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS11
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRPS11
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MRPS11
     LSBio Antibodies in human, mouse, rat for MRPS11
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      MRPS11 gene at Home site.
    Version: 3.12.158 12 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4