MRPS11 Gene
protein-coding GIFtS: 50
GCID: GC15P089010
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|
mitochondrial ribosomal protein S11
| |
Aliases for MRPS11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein S111 2 | | FLJ225121 | | HCC-21 2 3 | | FLJ234061 | | Cervical Cancer Proto-Oncogene 2 Protein2 3 | | 28S Ribosomal Protein S11, Mitochondrial2 | | MRP-S112 3 | | RPMS113 | | S11mt2 3 | | |
Export aliases for MRPS11 gene to outside databasesPrevious GC identifers: GC15P085107 GC15P082295 GC15P086597 GC15P086740 GC15P086811 GC15P065122 |
Summaries for MRPS11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for MRPS11: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit proteinthat contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogenecorresponding to this gene is found on chromosome 20. Sequence analysis identified two transcript variants that encodedifferent protein isoforms. (provided by RefSeq, Jul 2008) Gene Wiki entry for MRPS11
|
Genomic Views for MRPS11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010274.17
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the MRPS11 gene promoter: p53 Brachyury SREBP-1c STAT5A GATA-1 SREBP-1b S8 SREBP-1a POU2F1a Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPS11
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS11 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q25 Ensembl cytogenetic band: 15q25.3 HGNC cytogenetic band: 15q25MRPS11 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P089010: view genomic region
(about GC identifiers)
Start:
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89,010,684 bp from pter |
End:
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89,022,222 bp from pter |
Size:
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11,539 bases |
Orientation:
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plus strand |
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Proteins for MRPS11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: RT11_HUMAN, P82912 (See
protein sequence)Recommended Name: 28S ribosomal protein S11, mitochondrial precursor Size: 194 amino acids; 20616 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinctproteins
Subcellular location: Mitochondrion
Secondary accessions: B2RD52 Q969D7 Q96GI3 Q9BYC3Alternative splicing: 3 isoforms: P82912-1 P82912-2 P82912-3 Explore the universe of human proteins at neXtProt for MRPS11: NX_P82912
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P82912 MRPS11 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins (2 alternative transcripts):
NP_073750.2 NP_789775.1 ENSEMBL proteins: ENSP00000453116 ENSP00000317376 ENSP00000318054 Human Recombinant Protein Products for MRPS11:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MRPS11 for ontologies About GeneDecksing
MRPS11 Antibody Products: Assay Products for MRPS11: |
Protein
Domains / Families for MRPS11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPS11 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P82912ProtoNet protein and cluster: P82912 1 Blocks protein family: IPB001971 Ribosomal protein S11
UniProtKB/Swiss-Prot: RT11_HUMAN, P82912Similarity: Belongs to the ribosomal protein S11P family |
Function for MRPS11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
IEA | -- |
MRPS11 for ontologies About GeneDecksing
Phenotypes: 1 GenomeRNAi human phenotype for MRPS11: Animal Models:
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS11 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS11 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MRPS11 (NM_022839) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS11  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS11 |
|
Pathways & Interactions for MRPS11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS11
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/263 Interacting proteins for MRPS11 (P829122, 3 ENSP000003173764) via UniProtKB, MINT, STRING, and/or I2D (see all 263)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
MRPS11 for ontologies About GeneDecksing
|
Drugs & Compounds for MRPS11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for MRPS11 Search CenterWatch for drugs/clinical trials and news about MRPS11 / RT11 
|
Transcripts for MRPS11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for MRPS11 gene (2 alternative transcripts): NM_022839.3 NM_176805.2 Unigene Cluster for MRPS11: Mitochondrial ribosomal protein S11 Hs.111286 [show with all ESTs]Unigene Representative Sequence: AK02705911 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000560708 ENST00000325844(uc002bml.3 uc002bmm.3 uc002bmn.3) ENST00000559125 ENST00000557974 ENST00000559323(uc010bnj.3) ENST00000560850 ENST00000353598 ENST00000558406 ENST00000559557 ENST00000558548 ENST00000561262
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS11 (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPS11 (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): MRPS11 (NM_022839) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPS11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPS11  |
Additional cDNA sequence: AB049944.1 AK026165.1 AK027059.1 AK222933.1 AK223152.1 AK315407.1 AL110094.1 BC009451.1 BC012489.1 BC032378.1 14 DOTS entries: DT.100753201 DT.317377 DT.100790407 DT.97848415 DT.100790409 DT.75192684 DT.91750888 DT.95194578 DT.95194586 DT.91750890 DT.95093075 DT.95291154 DT.97801466 DT.95316579 24/253 AceView cDNA sequences (see all 253): BG250151 BU175439 BC009451 CA310139 BQ069101 BM979790 BQ084447 BM771428 BI258226 AA355412 BQ684284 BE407132 BM771455 BI259243 BQ222332 BM770730 BC012489 BQ020942 BG250651 CB111811 CR602512 CA306001 F20720 BE621219 GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS11 (see all 12) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · | 7f | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for MRPS11
|
Expression for MRPS11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPS11 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GGCGGCCTGG
 About this image See MRPS11 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for MRPS11
SOURCE GeneReport for Unigene cluster: Hs.111286 SABiosciences Custom PCR Arrays for MRPS11
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPS11 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPS11 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPS11 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS11 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS11 |
Orthologs for MRPS11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for MRPS11 gene from 9/33 species (see all 33) About this table
ENSEMBL Gene Tree for MRPS11 (if available) TreeFam Gene Tree for MRPS11 (if available)  |
Paralogs for MRPS11 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for MRPS11 gene
MRPS11 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MRPS11 PGOHUM00000247460
|
Genomic Variants for MRPS11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 15 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPS11 (89010684 - 89022222 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for MRPS11: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS11 |
|
Disorders
/ Diseases for MRPS11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRPS11 for disorders About GeneDecksing
OMIM gene information: 611977
OMIM disorders: --
5 diseases for MRPS11: About MalaCardscervical cancer cervicitis pneumonia tuberculosis mycobacterium tuberculosis Human Genome Epidemiology (HuGE) Navigator: MRPS11 (1 document) Export disorders for MRPS11 gene to outside databases
|
Publications for MRPS11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPS11 gene, integrated from 9 sources (see all 17): (articles sorted by number of sources associating them with MRPS11) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041)1, 2, 3 Suzuki T....Watanabe K. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2 Koc E.C.... Spremulli L.L. (2001)
- ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA. (PubMed id 15300802)1, 9 Ishiguchi H....Kohno K. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
|
External Searches for MRPS11 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing MRPS11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPS11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPS11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for MRPS11 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRPS11 gene: Search GeneIP for patents involving MRPS11
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for MRPS11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
|
 | |
 | |
 |
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 | | MRPS11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS11 |
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