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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

MRPS10 Gene

protein-coding   GIFtS: 47
GCID: GC06M042174

mitochondrial ribosomal protein S10

  Search for MRPS10
in our new
 Human Malady Compendium 
Biological research products
for MRPS10
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Mitochondrial Ribosomal Protein S101 2     28S Ribosomal Protein S10, Mitochondrial2
MRP-S102 3     PNAS-1222
S10mt2 3     Mitochondrial 28S Ribosomal Protein S102
FLJ105671     

External Ids:    HGNC: 145021   Entrez Gene: 551732   Ensembl: ENSG000000485447   OMIM: 6119765   UniProtKB: P826643   

Export aliases for MRPS10 gene to outside databases

Previous GC identifers: GC06M042176 GC06M042221 GC06M042282 GC06M041892


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MRPS10:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They
have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.
Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.
Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in
biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein
that belongs to the ribosomal protein S10P family. Pseudogenes corresponding to this gene are found on chromosomes 1q,
3p, and 9p. (provided by RefSeq, Jul 2008)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MRPS10 gene promoter:
         AREB6   TBP   USF1   USF-1   POU3F1   TFIID   Olf-1   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPS10 promoter sequence
   Search SABiosciences Chromatin IP Primers for MRPS10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPS10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

MRPS10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPS10 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M042174:  view genomic region     (about GC identifiers)

Start:
42,174,539 bp from pter      End:
42,185,633 bp from pter
Size:
11,095 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: RT10_HUMAN, P82664 (See protein sequence)
Recommended Name: 28S ribosomal protein S10, mitochondrial  
Size: 201 amino acids; 22999 Da
Subcellular location: Mitochondrion
Secondary accessions: B2RE89 Q9H3E5 Q9NVR3

Explore the universe of human proteins at neXtProt for MRPS10: NX_P82664

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P82664

  • MRPS10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060611.2  
    ENSEMBL proteins: 
     ENSP00000053468  

    Human Recombinant Protein Products: 
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    Uscn Proteins for MRPS10

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005840ribosome IEA--


    MRPS10 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MRPS10 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001848 Ribosomal_S10

    Graphical View of Domain Structure for InterPro Entry P82664

    ProtoNet protein and cluster: P82664

    1 Blocks protein family: IPB001848 Ribosomal protein S10

    UniProtKB/Swiss-Prot: RT10_HUMAN, P82664
    Similarity: Belongs to the ribosomal protein S10P family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    miRNA
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    hsa-miR-152 hsa-miR-3194-5p hsa-miR-148b hsa-miR-3127-5p hsa-miR-148a
    SwitchGear 3'UTR luciferase reporter plasmidMRPS10 3' UTR sequence
    Inhib. RNA
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003735structural constituent of ribosome IEA--


    MRPS10 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for MRPS10:
     Increased cell number in G2M,  


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPS10

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/232 Interacting proteins for MRPS10 (P826642, 3 ENSP000000534684) via UniProtKB, MINT, STRING, and/or I2D (see all 232)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    PHLDA3Q9Y5J53, ENSP000003562784I2D: score=1 STRING: ENSP00000356278
    AARS2Q5JTZ92MINT-8079030
    AASSQ9UDR52MINT-8079030
    ABCB7O750272MINT-8079030
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation IEA--
    GO:0008150biological_process ND--


    MRPS10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MRPS10
    Search CenterWatch for drugs/clinical trials and news about MRPS10 / RT10 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for MRPS10 gene: 
    NM_018141.3  

    Unigene Cluster for MRPS10:

    Mitochondrial ribosomal protein S10
    Hs.380887  [show with all ESTs]
    Unigene Representative Sequence: NM_018141
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000053468(uc003osa.4 uc011dup.2)

    miRNA
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    hsa-miR-152 hsa-miR-3194-5p hsa-miR-148b hsa-miR-3127-5p hsa-miR-148a
    SwitchGear 3'UTR luciferase reporter plasmidMRPS10 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPS10 (see all 6)
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPS10

    Additional cDNA sequence: 

    AF113220.1 AK001429.1 AK098446.1 AK298219.1 AK316599.1 BC012560.1 FJ423748.1 

    12 DOTS entries:

    DT.210646  DT.97759863  DT.91754100  DT.100028593  DT.86844133  DT.95349786  DT.97759864  DT.121377709 
    DT.95140436  DT.95349798  DT.100862025  DT.91763154 

    24/192 AceView cDNA sequences (see all 192):

    AI754661 BU161540 AA455191 BP339123 BQ050645 AI433286 BF115049 BC012560 
    AA457737 AW300686 CA388783 AV649265 BU164284 T30832 BM759269 AI968157 
    AI796273 AI953377 BX344395 Z45919 AA301578 AI580708 AA321688 AA454850 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for MRPS10    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
    SP1:                                                
    SP2:                                                
    SP3:                                                


    ECgene alternative splicing isoforms for MRPS10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    MRPS10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCTTCAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See MRPS10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for MRPS10

    SOURCE GeneReport for Unigene cluster: Hs.380887
        SABiosciences Custom PCR Arrays for MRPS10
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPS10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for MRPS10 gene from 7/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrps101 , 5 mitochondrial ribosomal protein S101, 5 80.1(n)1
    81.59(a)1
      17 (23.00 cM)5
    646571  NM_001146212.11  NP_001139684.11 
     473688875 
    chicken
    (Gallus gallus)
    Aves MRPS101 mitochondrial ribosomal protein S10 72.22(n)
    67.74(a)
      421385  XM_419444.3  XP_419444.2 
    lizard
    (Anolis carolinensis)
    Reptilia MRPS106
    --
    65(a)
    1 ↔ 1
    1(236866143-236871876)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.152142 Transcribed sequence with weak similarity to protein more 78.98(n)    CF781700.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.159902 Transcribed sequence with weak similarity to protein more 75(n)    AL925850.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpS101 , 3 protein biosynthesis structural constituent
    of more3
    mitochondrial ribosomal protein S101
    55(a)3
    54.44(n)1
    56.67(a)1
      88E33
    418381  NM_169624.21  NP_731985.21 
    worm
    (Caenorhabditis elegans)
    Secernentea mrps-101 Protein MRPS-10 47.99(n)
    43.97(a)
      189618  NM_067284.4  NP_499685.1 


    ENSEMBL Gene Tree for MRPS10 (if available)
    TreeFam Gene Tree for MRPS10 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for MRPS10 gene

    MRPS10 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for MRPS10
    PGOHUM00000245080 PGOHUM00000237523 PGOHUM00000236033 PGOHUM00000236457


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/308 NCBI SNPs in MRPS10 are shown (see all 308    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1834117901,2
    --42174128(+) AATCTC/TGGCTC 1 -- ds50010--------
    rs1476401781,2
    --42174211(+) CCCACC/GACCAT 1 -- ds50010--------
    rs1145861751,2
    F,--42174355(+) ACAACC/AGGCCG 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1486984851,2
    --42174372(+) TATTTA/GTTTTT 1 -- ds50010--------
    rs790297861,2
    --42174388(+) ATTACG/TTCAGA 1 -- ds50010--------
    rs47145791,2
    C,F,A,H,--42174478(+) CTTCAG/AGTACT 1 -- ds500125Minor allele frequency- A:0.29NA NS EA WA CSA 2487
    rs1872048361,2
    --42174512(+) AGGCAC/TTCATG 1 -- ds50010--------
    rs1511998921,2
    --42174538(+) CTGAGA/CTGAAG 1 -- ds50010--------
    rs603429671,2
    C,--42174540(+) GAGCTG/CAAGGT 1 -- ut312Minor allele frequency- C:0.31CSA WA 119
    rs47145801,2
    C,F,A,H,--42174558(+) CACAAG/AGCTGC 1 -- ut3133Minor allele frequency- A:0.11NA EA NS WA CSA 3099

    HapMap Linkage Disequilibrium report for MRPS10 (42174539 - 42185633 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MRPS10: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPS10
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPS10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MRPS10 for disorders           About MalaCards

    MRPS10 for disorders           About GeneDecksing

    OMIM gene information: 611976    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: MRPS10 (1 document)

    Export disorders for MRPS10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for MRPS10 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with MRPS10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 3 Koc E.C.... Spremulli L.L. (2001)
    5. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. (PubMed id 10938081)1, 2 Koc E.C....Spremulli L.L. (2000)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
    10. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55173 HGNC: 14502 AceView: MRPS10 Ensembl:ENSG00000048544 euGenes: HUgn55173
    ECgene: MRPS10 H-InvDB: MRPS10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for MRPS10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for MRPS10 gene:
    Search GeneIP for patents involving MRPS10

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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