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Aliases for MRPS10 Gene

Aliases for MRPS10 Gene

  • Mitochondrial Ribosomal Protein S10 2 3
  • MRP-S10 3 4
  • S10mt 3 4
  • Mitochondrial 28S Ribosomal Protein S10 3
  • PNAS-122 3

External Ids for MRPS10 Gene

Previous GeneCards Identifiers for MRPS10 Gene

  • GC06M042176
  • GC06M042221
  • GC06M042282
  • GC06M041892

Summaries for MRPS10 Gene

Entrez Gene Summary for MRPS10 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S10P family. Pseudogenes corresponding to this gene are found on chromosomes 1q, 3p, and 9p. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS10 Gene

MRPS10 (Mitochondrial Ribosomal Protein S10) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Viral mRNA Translation.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS10 Gene

Genomics for MRPS10 Gene

Regulatory Elements for MRPS10 Gene

Genomic Location for MRPS10 Gene

Chromosome:
6
Start:
42,206,801 bp from pter
End:
42,217,907 bp from pter
Size:
11,107 bases
Orientation:
Minus strand

Genomic View for MRPS10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS10 Gene

Proteins for MRPS10 Gene

  • Protein details for MRPS10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82664-RT10_HUMAN
    Recommended name:
    28S ribosomal protein S10, mitochondrial
    Protein Accession:
    P82664
    Secondary Accessions:
    • B2RE89
    • Q9H3E5
    • Q9NVR3

    Protein attributes for MRPS10 Gene

    Size:
    201 amino acids
    Molecular mass:
    22999 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPS10 Gene

neXtProt entry for MRPS10 Gene

Proteomics data for MRPS10 Gene at MOPED

Post-translational modifications for MRPS10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS10 Gene

Domains & Families for MRPS10 Gene

Gene Families for MRPS10 Gene

Protein Domains for MRPS10 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPS10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P82664

UniProtKB/Swiss-Prot:

RT10_HUMAN :
  • Belongs to the ribosomal protein S10P family.
Family:
  • Belongs to the ribosomal protein S10P family.
genes like me logo Genes that share domains with MRPS10: view

Function for MRPS10 Gene

Gene Ontology (GO) - Molecular Function for MRPS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MRPS10: view
genes like me logo Genes that share phenotypes with MRPS10: view

Animal Model Products

miRNA for MRPS10 Gene

miRTarBase miRNAs that target MRPS10

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS10

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS10 Gene

Localization for MRPS10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS10 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS10 Gene COMPARTMENTS Subcellular localization image for MRPS10 gene
Compartment Confidence
mitochondrion 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for MRPS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS10: view

Pathways & Interactions for MRPS10 Gene

genes like me logo Genes that share pathways with MRPS10: view

Gene Ontology (GO) - Biological Process for MRPS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006996 organelle organization TAS --
GO:0008150 biological_process ND --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPS10: view

No data available for SIGNOR curated interactions for MRPS10 Gene

Drugs & Compounds for MRPS10 Gene

No Compound Related Data Available

Transcripts for MRPS10 Gene

mRNA/cDNA for MRPS10 Gene

Unigene Clusters for MRPS10 Gene

Mitochondrial ribosomal protein S10:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1:
SP2:
SP3:

Relevant External Links for MRPS10 Gene

GeneLoc Exon Structure for
MRPS10
ECgene alternative splicing isoforms for
MRPS10

Expression for MRPS10 Gene

mRNA expression in normal human tissues for MRPS10 Gene

Protein differential expression in normal tissues from HIPED for MRPS10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.6), Pancreas (10.6), and Breast (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS10 Gene



SOURCE GeneReport for Unigene cluster for MRPS10 Gene Hs.380887

genes like me logo Genes that share expression patterns with MRPS10: view

Protein tissue co-expression partners for MRPS10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS10 Gene

Orthologs for MRPS10 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPS10 35
  • 89.22 (n)
  • 86.07 (a)
MRPS10 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS10 35
  • 89.22 (n)
  • 85.57 (a)
MRPS10 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrps10 35
  • 80.1 (n)
  • 81.59 (a)
Mrps10 16
Mrps10 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPS10 35
  • 99 (n)
  • 98.51 (a)
MRPS10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps10 35
  • 82.37 (n)
  • 86.45 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPS10 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS10 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS10 35
  • 72.22 (n)
  • 67.74 (a)
MRPS10 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPS10 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps10 35
  • 65.21 (n)
  • 65.62 (a)
Str.15214 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15990 35
mrps10 35
  • 63.59 (n)
  • 70.77 (a)
mrps10 36
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mRpS10 37
  • 55 (a)
mRpS10 35
  • 54.1 (n)
  • 55.74 (a)
mRpS10 36
  • 42 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001998 35
  • 53.67 (n)
  • 54.24 (a)
worm
(Caenorhabditis elegans)
Secernentea mrps-10 35
  • 48.81 (n)
  • 45.54 (a)
mrps-10 36
  • 33 (a)
OneToOne
Species with no ortholog for MRPS10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS10 Gene

ENSEMBL:
Gene Tree for MRPS10 (if available)
TreeFam:
Gene Tree for MRPS10 (if available)

Paralogs for MRPS10 Gene

Pseudogenes.org Pseudogenes for MRPS10 Gene

genes like me logo Genes that share paralogs with MRPS10: view

No data available for Paralogs for MRPS10 Gene

Variants for MRPS10 Gene

Sequence variations from dbSNP and Humsavar for MRPS10 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1884317 -- 42,214,445(-) TCTTC(A/G)TCTGA intron-variant
rs1884318 -- 42,214,222(-) TTTAC(G/T)TAGGT intron-variant
rs2273281 -- 42,214,774(-) TACTT(C/T)AGAAT intron-variant
rs2273282 -- 42,214,686(-) ACTGA(A/G)GTACA intron-variant
rs2273283 -- 42,214,035(-) CCAAA(C/T)ACTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS10 Gene

Variant ID Type Subtype PubMed ID
nsv830649 CNV Loss 17160897

Variation tolerance for MRPS10 Gene

Residual Variation Intolerance Score: 76.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS10 Gene

HapMap Linkage Disequilibrium report
MRPS10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS10 Gene

Disorders for MRPS10 Gene

Relevant External Links for MRPS10

Genetic Association Database (GAD)
MRPS10
Human Genome Epidemiology (HuGE) Navigator
MRPS10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS10
genes like me logo Genes that share disorders with MRPS10: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS10 Gene

Publications for MRPS10 Gene

  1. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 67
  5. p32/gC1qR is indispensable for fetal development and mitochondrial translation: importance of its RNA-binding ability. (PMID: 22904065) Yagi M. … Kang D. (Nucleic Acids Res. 2012) 67

Products for MRPS10 Gene

Sources for MRPS10 Gene

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