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Aliases for MRPS10 Gene

Aliases for MRPS10 Gene

  • Mitochondrial Ribosomal Protein S10 2 3 5
  • MRP-S10 3 4
  • S10mt 3 4
  • Mitochondrial 28S Ribosomal Protein S10 3
  • PNAS-122 3

External Ids for MRPS10 Gene

Previous GeneCards Identifiers for MRPS10 Gene

  • GC06M042176
  • GC06M042221
  • GC06M042282
  • GC06M041892

Summaries for MRPS10 Gene

Entrez Gene Summary for MRPS10 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S10P family. Pseudogenes corresponding to this gene are found on chromosomes 1q, 3p, and 9p. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS10 Gene

MRPS10 (Mitochondrial Ribosomal Protein S10) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS10 Gene

Genomics for MRPS10 Gene

Regulatory Elements for MRPS10 Gene

Promoters for MRPS10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPS10 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPS10 Gene

Chromosome:
6
Start:
42,206,801 bp from pter
End:
42,217,907 bp from pter
Size:
11,107 bases
Orientation:
Minus strand

Genomic View for MRPS10 Gene

Genes around MRPS10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS10 Gene

Proteins for MRPS10 Gene

  • Protein details for MRPS10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82664-RT10_HUMAN
    Recommended name:
    28S ribosomal protein S10, mitochondrial
    Protein Accession:
    P82664
    Secondary Accessions:
    • B2RE89
    • Q9H3E5
    • Q9NVR3

    Protein attributes for MRPS10 Gene

    Size:
    201 amino acids
    Molecular mass:
    22999 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPS10 Gene

neXtProt entry for MRPS10 Gene

Proteomics data for MRPS10 Gene at MOPED

Post-translational modifications for MRPS10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPS10 Gene

Domains & Families for MRPS10 Gene

Gene Families for MRPS10 Gene

Protein Domains for MRPS10 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPS10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P82664

UniProtKB/Swiss-Prot:

RT10_HUMAN :
  • Belongs to the ribosomal protein S10P family.
Family:
  • Belongs to the ribosomal protein S10P family.
genes like me logo Genes that share domains with MRPS10: view

Function for MRPS10 Gene

genes like me logo Genes that share phenotypes with MRPS10: view

Animal Model Products

miRNA for MRPS10 Gene

miRTarBase miRNAs that target MRPS10

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS10 Gene

Localization for MRPS10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS10 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS10 Gene COMPARTMENTS Subcellular localization image for MRPS10 gene
Compartment Confidence
mitochondrion 5
cytoskeleton 2
cytosol 2
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for MRPS10 Gene

Pathways & Interactions for MRPS10 Gene

genes like me logo Genes that share pathways with MRPS10: view

Gene Ontology (GO) - Biological Process for MRPS10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
GO:0098792 xenophagy IMP 22020285
genes like me logo Genes that share ontologies with MRPS10: view

No data available for SIGNOR curated interactions for MRPS10 Gene

Drugs & Compounds for MRPS10 Gene

No Compound Related Data Available

Transcripts for MRPS10 Gene

mRNA/cDNA for MRPS10 Gene

Unigene Clusters for MRPS10 Gene

Mitochondrial ribosomal protein S10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1:
SP2:
SP3:

Relevant External Links for MRPS10 Gene

GeneLoc Exon Structure for
MRPS10
ECgene alternative splicing isoforms for
MRPS10

Expression for MRPS10 Gene

mRNA expression in normal human tissues for MRPS10 Gene

Protein differential expression in normal tissues from HIPED for MRPS10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.6), Pancreas (10.6), and Breast (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS10 Gene



SOURCE GeneReport for Unigene cluster for MRPS10 Gene Hs.380887

genes like me logo Genes that share expression patterns with MRPS10: view

Protein tissue co-expression partners for MRPS10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS10 Gene

Orthologs for MRPS10 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS10 36
  • 99 (a)
OneToOne
MRPS10 35
  • 99 (n)
  • 98.51 (a)
cow
(Bos Taurus)
Mammalia MRPS10 35
  • 89.22 (n)
  • 86.07 (a)
MRPS10 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS10 36
  • 86 (a)
OneToOne
MRPS10 35
  • 89.22 (n)
  • 85.57 (a)
mouse
(Mus musculus)
Mammalia Mrps10 36
  • 82 (a)
OneToOne
Mrps10 16
Mrps10 35
  • 80.1 (n)
  • 81.59 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPS10 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS10 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps10 35
  • 82.37 (n)
  • 86.45 (a)
chicken
(Gallus gallus)
Aves MRPS10 35
  • 72.22 (n)
  • 67.74 (a)
MRPS10 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPS10 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrps10 35
  • 65.21 (n)
  • 65.62 (a)
Str.15214 35
zebrafish
(Danio rerio)
Actinopterygii mrps10 36
  • 55 (a)
OneToOne
Dr.15990 35
mrps10 35
  • 63.59 (n)
  • 70.77 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001998 35
  • 53.67 (n)
  • 54.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS10 36
  • 42 (a)
OneToOne
mRpS10 37
  • 55 (a)
mRpS10 35
  • 54.1 (n)
  • 55.74 (a)
worm
(Caenorhabditis elegans)
Secernentea mrps-10 35
  • 48.81 (n)
  • 45.54 (a)
mrps-10 36
  • 33 (a)
OneToOne
Species with no ortholog for MRPS10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS10 Gene

ENSEMBL:
Gene Tree for MRPS10 (if available)
TreeFam:
Gene Tree for MRPS10 (if available)

Paralogs for MRPS10 Gene

Pseudogenes.org Pseudogenes for MRPS10 Gene

genes like me logo Genes that share paralogs with MRPS10: view

No data available for Paralogs for MRPS10 Gene

Variants for MRPS10 Gene

Sequence variations from dbSNP and Humsavar for MRPS10 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1884317 -- 42,214,445(-) TCTTC(A/G)TCTGA intron-variant
rs2273281 -- 42,214,774(-) TACTT(C/T)AGAAT intron-variant
rs2295277 -- 42,210,840(-) TGCTT(C/G)CACAC intron-variant
rs3215606 -- 42,214,638(-) TTTTT(-/T)CTTGA intron-variant
rs3215607 -- 42,214,484(-) TTTTT(-/T)CAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS10 Gene

Variant ID Type Subtype PubMed ID
nsv830649 CNV Loss 17160897

Variation tolerance for MRPS10 Gene

Residual Variation Intolerance Score: 76.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS10 Gene

HapMap Linkage Disequilibrium report
MRPS10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS10 Gene

Disorders for MRPS10 Gene

Relevant External Links for MRPS10

Genetic Association Database (GAD)
MRPS10
Human Genome Epidemiology (HuGE) Navigator
MRPS10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS10

No disorders were found for MRPS10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS10 Gene

Publications for MRPS10 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3

Products for MRPS10 Gene

Sources for MRPS10 Gene

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