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Aliases for MRPL9 Gene

Aliases for MRPL9 Gene

  • Mitochondrial Ribosomal Protein L9 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein BL9m 3 4
  • L9mt 3 4
  • 39S Ribosomal Protein L9, Mitochondrial 3
  • MRP-L9 4

External Ids for MRPL9 Gene

Previous GeneCards Identifiers for MRPL9 Gene

  • GC01M149572
  • GC01M147514
  • GC01M148507
  • GC01M148948
  • GC01M148545
  • GC01M149998
  • GC01M151732
  • GC01M123108

Summaries for MRPL9 Gene

Entrez Gene Summary for MRPL9 Gene

  • This is a nuclear gene encoding a protein component of the 39S subunit of the mitochondrial ribosome. Alternative splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Jul 2014]

GeneCards Summary for MRPL9 Gene

MRPL9 (Mitochondrial Ribosomal Protein L9) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Additional gene information for MRPL9 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL9 Gene

Genomics for MRPL9 Gene

GeneHancer (GH) Regulatory Elements for MRPL9 Gene

Promoters and enhancers for MRPL9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I151762 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.5 465 2.4 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B OAZ3 MRPL9 SETDB1 ZNF687 PI4KB UBE2D3P3 SNX27 CTSK ENSG00000249602 RIIAD1
GH01I151940 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 100.6 -180.2 -180182 7.6 PKNOX1 CLOCK FOXA2 NEUROD1 SIN3A FEZF1 ZNF2 ZBTB7B ZNF416 FOS POGZ GABPB2 PI4KB MRPL9 PIP5K1A LYSMD1 ENSG00000229021 HRNR THEM4 ZNF687
GH01I151068 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 64.4 +693.4 693430 3.3 CLOCK FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 GABPB2 CDC42SE1 PRPF3 SETDB1 PI4KB PIP5K1A MRPL9 UBE2D3P3 ARNT CTSK
GH01I151004 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 37 +756.5 756471 5.2 CLOCK ZFP64 YBX1 YY1 ZNF213 E2F8 ZNF143 SP3 ZNF610 GLIS1 MINDY1 PRUNE1 PI4KB SETDB1 PIP5K1A PRPF3 GABPB2 GOLPH3L CTSK MRPL9
GH01I150969 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 28.7 +789.0 788959 10.6 CLOCK MLX ZFP64 DMAP1 YY1 E2F8 ZNF143 SP3 SSRP1 GLIS1 CERS2 ENSG00000231073 PRPF3 SETDB1 ZNF687 HORMAD1 PIP5K1A ARNT GOLPH3L PI4KB
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MRPL9 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPL9 gene promoter:

Genomic Locations for MRPL9 Gene

Genomic Locations for MRPL9 Gene
chr1:151,759,643-151,763,916
(GRCh38/hg38)
Size:
4,274 bases
Orientation:
Minus strand
chr1:151,732,119-151,736,040
(GRCh37/hg19)

Genomic View for MRPL9 Gene

Genes around MRPL9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL9 Gene

Proteins for MRPL9 Gene

  • Protein details for MRPL9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYD2-RM09_HUMAN
    Recommended name:
    39S ribosomal protein L9, mitochondrial
    Protein Accession:
    Q9BYD2
    Secondary Accessions:
    • B2RD99
    • Q5SZR2
    • Q9BSW8

    Protein attributes for MRPL9 Gene

    Size:
    267 amino acids
    Molecular mass:
    30243 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL9 Gene

neXtProt entry for MRPL9 Gene

Post-translational modifications for MRPL9 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MRPL9 Gene

Domains & Families for MRPL9 Gene

Gene Families for MRPL9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPL9 Gene

Suggested Antigen Peptide Sequences for MRPL9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYD2

UniProtKB/Swiss-Prot:

RM09_HUMAN :
  • Belongs to the bacterial ribosomal protein bL9 family.
Family:
  • Belongs to the bacterial ribosomal protein bL9 family.
genes like me logo Genes that share domains with MRPL9: view

Function for MRPL9 Gene

Phenotypes From GWAS Catalog for MRPL9 Gene

Gene Ontology (GO) - Molecular Function for MRPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IBA --
GO:0003735 structural constituent of ribosome NAS,IEA 11543634
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MRPL9: view

Phenotypes for MRPL9 Gene

GenomeRNAi human phenotypes for MRPL9:
genes like me logo Genes that share phenotypes with MRPL9: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL9 Gene

Localization for MRPL9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL9 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL9 gene
Compartment Confidence
mitochondrion 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome NAS 11543634
GO:0005762 mitochondrial large ribosomal subunit IDA 25278503
genes like me logo Genes that share ontologies with MRPL9: view

Pathways & Interactions for MRPL9 Gene

genes like me logo Genes that share pathways with MRPL9: view

Gene Ontology (GO) - Biological Process for MRPL9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation NAS,IEA 11543634
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL9: view

No data available for SIGNOR curated interactions for MRPL9 Gene

Drugs & Compounds for MRPL9 Gene

No Compound Related Data Available

Transcripts for MRPL9 Gene

Unigene Clusters for MRPL9 Gene

Mitochondrial ribosomal protein L9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL9 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - - - - -
SP6: -
SP7:
SP8: - - -
SP9: -

Relevant External Links for MRPL9 Gene

GeneLoc Exon Structure for
MRPL9
ECgene alternative splicing isoforms for
MRPL9

Expression for MRPL9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL9 Gene

Protein differential expression in normal tissues from HIPED for MRPL9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.4), Lung (8.6), Pancreas (7.7), and Adrenal (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL9 Gene



Protein tissue co-expression partners for MRPL9 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL9 Gene:

MRPL9

SOURCE GeneReport for Unigene cluster for MRPL9 Gene:

Hs.288936

Evidence on tissue expression from TISSUES for MRPL9 Gene

  • Lung(4.7)
  • Eye(2.7)
  • Nervous system(2.3)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with MRPL9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL9 Gene

Orthologs for MRPL9 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL9 34 33
  • 99.63 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl9 16 34 33
  • 84.22 (n)
rat
(Rattus norvegicus)
Mammalia mrpl9 33
  • 83.8 (n)
cow
(Bos Taurus)
Mammalia MRPL9 33 34
  • 83.63 (n)
chicken
(Gallus gallus)
Aves MRPL9 34 33
  • 65.56 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL9 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20048 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.2544 33
zebrafish
(Danio rerio)
Actinopterygii mrpl9 33 34
  • 59.2 (n)
wufa98b03 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8308 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000950 33
  • 46.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta mRpL9 33 34
  • 45.17 (n)
Species where no ortholog for MRPL9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL9 Gene

ENSEMBL:
Gene Tree for MRPL9 (if available)
TreeFam:
Gene Tree for MRPL9 (if available)

Paralogs for MRPL9 Gene

Pseudogenes.org Pseudogenes for MRPL9 Gene

genes like me logo Genes that share paralogs with MRPL9: view

No data available for Paralogs for MRPL9 Gene

Variants for MRPL9 Gene

Sequence variations from dbSNP and Humsavar for MRPL9 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs57922119 benign, not specified 151,760,904(-) AAAAAAAAAAAAAAAAAAAAAAA/AAAAAAAAAAAAAAA/AAAAAAAAAAAAAAAAAAAAA/AAAAAAAAAAAAAAAAAAAAAA/AAAAAAAAAAAAAAAAAAAAAAAA/AAAAAAAAAAAAAAAAAAAAAAAAA/AAAAAAAAAAAAAAAAAAAAAAAAAA/AAAAAAAAAAAAAAAAAAAAAAAAAAA/AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA/AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA/AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA genic_downstream_transcript_variant, intron_variant
rs1000681460 -- 151,761,067(-) T/C downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1001020223 -- 151,759,515(-) A/C downstream_transcript_variant
rs1001105807 -- 151,765,278(-) T/C upstream_transcript_variant
rs1001130916 -- 151,764,478(-) C/G/T upstream_transcript_variant

Variation tolerance for MRPL9 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.77; 78.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPL9 Gene

Disorders for MRPL9 Gene

Additional Disease Information for MRPL9

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPL9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL9 Gene

Publications for MRPL9 Gene

  1. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 58
  2. Use of genome-wide expression data to mine the "Gray Zone" of GWA studies leads to novel candidate obesity genes. (PMID: 20532202) Naukkarinen J … ENGAGE Consortium (PLoS genetics 2010) 3 44 58
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for MRPL9 Gene

Sources for MRPL9 Gene

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