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Aliases for MRPL58 Gene

Aliases for MRPL58 Gene

  • Mitochondrial Ribosomal Protein L58 2 3 5
  • Immature Colon Carcinoma Transcript 1 Protein 3 4
  • 39S Ribosomal Protein L58, Mitochondrial 3 4
  • Digestion Substraction 1 3 4
  • MRP-L58 3 4
  • ICT1 3 4
  • DS-1 3 4
  • DS1 3 4
  • Peptidyl-TRNA Hydrolase ICT1, Mitochondrial 3
  • Immature Colon Carcinoma Transcript 1 2
  • EC 3.1.1.29 4

External Ids for MRPL58 Gene

Previous HGNC Symbols for MRPL58 Gene

  • ICT1

Summaries for MRPL58 Gene

Entrez Gene Summary for MRPL58 Gene

  • The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for MRPL58 Gene

MRPL58 (Mitochondrial Ribosomal Protein L58) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance.

UniProtKB/Swiss-Prot for MRPL58 Gene

  • Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL58 Gene

Genomics for MRPL58 Gene

Regulatory Elements for MRPL58 Gene

Enhancers for MRPL58 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F074974 0.2 ENCODE 11.5 -37.7 -37650 1.3 ZNF121 KLF1 ZNF24 OTOP3 MRPL58 RNU6-362P FADS6 FDXR KCTD2 ATP5H HID1 GC17P074982
GH17F075010 1.2 FANTOM5 ENCODE 10.7 -0.5 -462 3.7 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 UNK HID1 ENSG00000267801 ENSG00000266980 ENSG00000264829 NUP85 KCTD2 CDR2L NT5C HID1-AS1
GH17F075018 0.6 ENCODE 7.4 +6.2 6161 0.4 BCOR MTA2 TAL1 ARID1B MEF2D NCOR1 GATA2 ADNP TRIM24 HID1 CDR2L ATP5H MRPL58 GC17M075029
GH17F075020 0.6 ENCODE 7.2 +7.9 7913 1.0 ZNF217 GATA3 CTBP1 SCRT2 ZMYM3 DPF2 TCF7L2 CDR2L HID1 ATP5H OTOP3 MRPL58 MYO15B GC17M075029
GH17F075123 1 FANTOM5 Ensembl ENCODE 6.8 +112.4 112376 3.1 ATF1 PKNOX1 SIN3A BRCA1 GLIS2 GATA2 KLF7 FOS JUNB ZHX2 NUP85 HN1 NT5C SUMO2 ATP5H KCTD2 MRPL58 MRPS7 TSEN54 SLC16A5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around MRPL58 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL58 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001353179 36 1801 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for MRPL58 Gene

Chromosome:
17
Start:
75,012,664 bp from pter
End:
75,021,261 bp from pter
Size:
8,598 bases
Orientation:
Plus strand

Genomic View for MRPL58 Gene

Genes around MRPL58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL58 Gene

Proteins for MRPL58 Gene

  • Protein details for MRPL58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14197-ICT1_HUMAN
    Recommended name:
    Peptidyl-tRNA hydrolase ICT1, mitochondrial
    Protein Accession:
    Q14197
    Secondary Accessions:
    • B2RAD1
    • Q53HM7
    • Q53Y11

    Protein attributes for MRPL58 Gene

    Size:
    206 amino acids
    Molecular mass:
    23630 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL58 Gene

neXtProt entry for MRPL58 Gene

Post-translational modifications for MRPL58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL58 Gene

No data available for DME Specific Peptides for MRPL58 Gene

Domains & Families for MRPL58 Gene

Protein Domains for MRPL58 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14197

UniProtKB/Swiss-Prot:

ICT1_HUMAN :
  • Belongs to the prokaryotic/mitochondrial release factor family. ICT1 subfamily.
Family:
  • Belongs to the prokaryotic/mitochondrial release factor family. ICT1 subfamily.
genes like me logo Genes that share domains with MRPL58: view

No data available for Gene Families for MRPL58 Gene

Function for MRPL58 Gene

Molecular function for MRPL58 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
N-substituted aminoacyl-tRNA + H(2)O = N-substituted amino acid + tRNA.
UniProtKB/Swiss-Prot Function:
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.

Enzyme Numbers (IUBMB) for MRPL58 Gene

Gene Ontology (GO) - Molecular Function for MRPL58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004045 aminoacyl-tRNA hydrolase activity IEA,IDA 20186120
GO:0016149 NOT translation release factor activity, codon specific IBA --
GO:0016150 translation release factor activity, codon nonspecific IDA 20186120
GO:0016787 hydrolase activity IEA --
GO:0043022 ribosome binding IBA --
genes like me logo Genes that share ontologies with MRPL58: view
genes like me logo Genes that share phenotypes with MRPL58: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MRPL58

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL58 Gene

Localization for MRPL58 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL58 Gene

Mitochondrion.

Gene Ontology (GO) - Cellular Components for MRPL58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA,IDA 20186120
GO:0005743 mitochondrial inner membrane TAS --
GO:0005759 mitochondrial matrix TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 20186120
genes like me logo Genes that share ontologies with MRPL58: view

No data available for Subcellular locations from COMPARTMENTS for MRPL58 Gene

Pathways & Interactions for MRPL58 Gene

genes like me logo Genes that share pathways with MRPL58: view

Gene Ontology (GO) - Biological Process for MRPL58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006415 translational termination IEA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
GO:0072344 rescue of stalled ribosome IBA --
genes like me logo Genes that share ontologies with MRPL58: view

No data available for SIGNOR curated interactions for MRPL58 Gene

Drugs & Compounds for MRPL58 Gene

(1) Drugs for MRPL58 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with MRPL58: view

Transcripts for MRPL58 Gene

Unigene Clusters for MRPL58 Gene

Immature colon carcinoma transcript 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL58 Gene

No ASD Table

Relevant External Links for MRPL58 Gene

GeneLoc Exon Structure for
MRPL58
ECgene alternative splicing isoforms for
MRPL58

Expression for MRPL58 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of MRPL58 Gene:

MRPL58

SOURCE GeneReport for Unigene cluster for MRPL58 Gene:

Hs.407955

mRNA Expression by UniProt/SwissProt for MRPL58 Gene:

Q14197-ICT1_HUMAN
Tissue specificity: Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells.
genes like me logo Genes that share expression patterns with MRPL58: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MRPL58 Gene

Orthologs for MRPL58 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRPL58 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ICT1 34 35
  • 99.19 (n)
dog
(Canis familiaris)
Mammalia ICT1 35
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ICT1 34 35
  • 83.17 (n)
mouse
(Mus musculus)
Mammalia Ict1 34 16 35
  • 81.73 (n)
rat
(Rattus norvegicus)
Mammalia Ict1 34
  • 81.72 (n)
oppossum
(Monodelphis domestica)
Mammalia ICT1 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ICT1 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ICT1 34 35
  • 63.53 (n)
lizard
(Anolis carolinensis)
Reptilia ICT1 35
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ict1 34
  • 60.34 (n)
Str.10297 34
zebrafish
(Danio rerio)
Actinopterygii LOC100149182 34
  • 57.86 (n)
ICT1 35
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6094 34 35
  • 49.8 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008425 34
  • 48.08 (n)
worm
(Caenorhabditis elegans)
Secernentea R02F2.9 34 35
  • 46.91 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 27 (a)
OneToOne
PTH4 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G62850 34
  • 48.48 (n)
rice
(Oryza sativa)
Liliopsida Os03g0249200 34
  • 49.52 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.345 35
  • 33 (a)
OneToOne
Species where no ortholog for MRPL58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL58 Gene

ENSEMBL:
Gene Tree for MRPL58 (if available)
TreeFam:
Gene Tree for MRPL58 (if available)

Paralogs for MRPL58 Gene

No data available for Paralogs for MRPL58 Gene

Variants for MRPL58 Gene

Sequence variations from dbSNP and Humsavar for MRPL58 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1044228 -- 75,020,526(+) ATCCT(C/T)ACCTC reference, synonymous-codon
rs10512599 -- 75,019,707(-) ATTGT(C/G)AAGCG reference, missense
rs10574182 -- 75,011,988(+) CTTCT(-/C)CTCCC upstream-variant-2KB
rs10649794 -- 75,016,582(+) GAGAG(-/GA)AGACA intron-variant, utr-variant-5-prime
rs11077771 -- 75,011,759(+) CACTG(A/C)TTGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRPL58 Gene

Variant ID Type Subtype PubMed ID
nsv1056788 CNV gain 25217958
nsv833540 CNV loss 17160897

Variation tolerance for MRPL58 Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL58 Gene

Disorders for MRPL58 Gene

Relevant External Links for MRPL58

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL58
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL58

No disorders were found for MRPL58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL58 Gene

Publications for MRPL58 Gene

  1. Identification of mRNAs that show modulated expression during colon carcinoma cell differentiation. (PMID: 8575443) van Belzen N. … Bosman F.T. (Eur. J. Biochem. 1995) 2 3 4 22 64
  2. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PMID: 20186120) Richter R. … Chrzanowska-Lightowlers Z.M. (EMBO J. 2010) 2 3 4 64
  3. Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria. (PMID: 27029019) Feaga H.A. … Keiler K.C. (PLoS Genet. 2016) 2 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for MRPL58 Gene

Sources for MRPL58 Gene

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