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Aliases for MRPL58 Gene

Aliases for MRPL58 Gene

  • Mitochondrial Ribosomal Protein L58 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein ML62 3 4
  • Immature Colon Carcinoma Transcript 1 Protein 3 4
  • 39S Ribosomal Protein L58, Mitochondrial 3 4
  • Digestion Substraction 1 3 4
  • MRP-L58 3 4
  • ICT1 3 4
  • DS-1 3 4
  • DS1 3 4
  • Mitochondrial Large Ribosomal Subunit Protein ICT1 3
  • Peptidyl-TRNA Hydrolase ICT1, Mitochondrial 3
  • Immature Colon Carcinoma Transcript 1 2
  • EC 3.1.1.29 4

External Ids for MRPL58 Gene

Previous HGNC Symbols for MRPL58 Gene

  • ICT1

Summaries for MRPL58 Gene

Entrez Gene Summary for MRPL58 Gene

  • The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

GeneCards Summary for MRPL58 Gene

MRPL58 (Mitochondrial Ribosomal Protein L58) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance.

UniProtKB/Swiss-Prot for MRPL58 Gene

  • Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.

Additional gene information for MRPL58 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL58 Gene

Genomics for MRPL58 Gene

Regulatory Elements for MRPL58 Gene

Enhancers for MRPL58 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H075010 1.7 FANTOM5 ENCODE dbSUPER 10.7 -0.5 -462 3 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A UNK GGA3 HID1 NUP85 CDK3 NT5C ENSG00000266980 KCTD2 CDR2L ENSG00000264829
GH17H075123 1.9 FANTOM5 Ensembl ENCODE dbSUPER 6.9 +112.3 112277 2 HDGF PKNOX1 ATF1 ARNT SIN3A BRCA1 YY1 TCF12 ZNF766 GLIS2 NUP85 JPT1 NT5C ATP5H KCTD2 MRPL58 MRPS7 TSEN54 SLC16A5 CD300LF
GH17H075085 2 FANTOM5 Ensembl ENCODE dbSUPER 6.3 +78.8 78832 11 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A YBX1 ZNF2 NUP85 UNK NT5C ENSG00000266980 ENSG00000267342 NAT9 GGA3 TRIM65 RN7SL573P SAP30BP
GH17H075031 1.8 FANTOM5 ENCODE dbSUPER 5.4 +22.0 21957 5 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC NUP85 UNK ENSG00000266980 GGA3 NT5C TRIM65 ENSG00000267342 KCTD2 ATP5H RN7SL573P
GH17H074426 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.3 -582.0 -582039 8 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 NAT9 GPRC5C ENSG00000266765 LINC02092 ENSG00000265927 ENSG00000265935 RN7SL573P NUP85 MRPL58 DNAI2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL58 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL58 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098301 236 1401 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A

Genomic Location for MRPL58 Gene

Chromosome:
17
Start:
75,012,664 bp from pter
End:
75,021,261 bp from pter
Size:
8,598 bases
Orientation:
Plus strand

Genomic View for MRPL58 Gene

Genes around MRPL58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL58 Gene

Proteins for MRPL58 Gene

  • Protein details for MRPL58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14197-ICT1_HUMAN
    Recommended name:
    Peptidyl-tRNA hydrolase ICT1, mitochondrial
    Protein Accession:
    Q14197
    Secondary Accessions:
    • B2RAD1
    • Q53HM7
    • Q53Y11

    Protein attributes for MRPL58 Gene

    Size:
    206 amino acids
    Molecular mass:
    23630 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL58 Gene

neXtProt entry for MRPL58 Gene

Post-translational modifications for MRPL58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL58 Gene

No data available for DME Specific Peptides for MRPL58 Gene

Domains & Families for MRPL58 Gene

Gene Families for MRPL58 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for MRPL58 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14197

UniProtKB/Swiss-Prot:

ICT1_HUMAN :
  • Belongs to the prokaryotic/mitochondrial release factor family. Mitochondrion-specific ribosomal protein mL62 subfamily.
Family:
  • Belongs to the prokaryotic/mitochondrial release factor family. Mitochondrion-specific ribosomal protein mL62 subfamily.
genes like me logo Genes that share domains with MRPL58: view

Function for MRPL58 Gene

Molecular function for MRPL58 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
N-substituted aminoacyl-tRNA + H(2)O = N-substituted amino acid + tRNA.
UniProtKB/Swiss-Prot Function:
Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.

Enzyme Numbers (IUBMB) for MRPL58 Gene

Phenotypes From GWAS Catalog for MRPL58 Gene

Gene Ontology (GO) - Molecular Function for MRPL58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004045 aminoacyl-tRNA hydrolase activity IDA,IEA 20186120
GO:0016150 translation release factor activity, codon nonspecific IDA 20186120
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MRPL58: view
genes like me logo Genes that share phenotypes with MRPL58: view

Animal Model Products

  • Taconic Biosciences Mouse Models for MRPL58

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MRPL58
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL58 Gene

Localization for MRPL58 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL58 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL58 gene
Compartment Confidence
mitochondrion 5
nucleus 3
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MRPL58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA,IEA 20186120
GO:0005743 mitochondrial inner membrane TAS --
GO:0005759 mitochondrial matrix TAS --
GO:0005762 mitochondrial large ribosomal subunit IDA 20186120
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL58: view

Pathways & Interactions for MRPL58 Gene

genes like me logo Genes that share pathways with MRPL58: view

Gene Ontology (GO) - Biological Process for MRPL58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0006415 translational termination IEA --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination IDA,TAS --
GO:0072344 rescue of stalled ribosome IBA --
genes like me logo Genes that share ontologies with MRPL58: view

No data available for SIGNOR curated interactions for MRPL58 Gene

Drugs & Compounds for MRPL58 Gene

(1) Drugs for MRPL58 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
genes like me logo Genes that share compounds with MRPL58: view

Transcripts for MRPL58 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MRPL58
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL58 Gene

No ASD Table

Relevant External Links for MRPL58 Gene

GeneLoc Exon Structure for
MRPL58
ECgene alternative splicing isoforms for
MRPL58

Expression for MRPL58 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of MRPL58 Gene:

MRPL58

mRNA Expression by UniProt/SwissProt for MRPL58 Gene:

Q14197-ICT1_HUMAN
Tissue specificity: Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells.

Evidence on tissue expression from TISSUES for MRPL58 Gene

  • Kidney(2)
genes like me logo Genes that share expression patterns with MRPL58: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL58 Gene

Orthologs for MRPL58 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MRPL58 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ICT1 33 34
  • 99.19 (n)
dog
(Canis familiaris)
Mammalia ICT1 34
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ICT1 33 34
  • 83.17 (n)
mouse
(Mus musculus)
Mammalia Ict1 33 34
  • 81.73 (n)
Mrpl58 16
rat
(Rattus norvegicus)
Mammalia Ict1 33
  • 81.72 (n)
oppossum
(Monodelphis domestica)
Mammalia ICT1 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ICT1 34
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ICT1 33 34
  • 63.53 (n)
lizard
(Anolis carolinensis)
Reptilia ICT1 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ict1 33
  • 60.34 (n)
Str.10297 33
zebrafish
(Danio rerio)
Actinopterygii LOC100149182 33
  • 57.86 (n)
ICT1 34
  • 44 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6094 33 34
  • 49.8 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008425 33
  • 48.08 (n)
worm
(Caenorhabditis elegans)
Secernentea R02F2.9 33 34
  • 46.91 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 27 (a)
OneToOne
PTH4 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G62850 33
  • 48.48 (n)
rice
(Oryza sativa)
Liliopsida Os03g0249200 33
  • 49.52 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.345 34
  • 33 (a)
OneToOne
Species where no ortholog for MRPL58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL58 Gene

ENSEMBL:
Gene Tree for MRPL58 (if available)
TreeFam:
Gene Tree for MRPL58 (if available)

Paralogs for MRPL58 Gene

No data available for Paralogs for MRPL58 Gene

Variants for MRPL58 Gene

Sequence variations from dbSNP and Humsavar for MRPL58 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000228315 -- 75,011,651(+) AACAA(C/T)CGCTA upstream-variant-2KB
rs1000305013 -- 75,017,272(+) GGCAA(C/T)GAGAG intron-variant
rs1000333716 -- 75,012,557(+) GCATC(A/G)GCGGG upstream-variant-2KB
rs1000601715 -- 75,011,353(+) CGTCT(A/C)TTCCC upstream-variant-2KB
rs1000670033 -- 75,013,691(+) TTGAA(A/T)AACGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL58 Gene

Variant ID Type Subtype PubMed ID
nsv1056788 CNV gain 25217958
nsv833540 CNV loss 17160897

Variation tolerance for MRPL58 Gene

Residual Variation Intolerance Score: 74.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.34; 53.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL58 Gene

Disorders for MRPL58 Gene

Relevant External Links for MRPL58

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL58
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL58

No disorders were found for MRPL58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL58 Gene

Publications for MRPL58 Gene

  1. Identification of mRNAs that show modulated expression during colon carcinoma cell differentiation. (PMID: 8575443) van Belzen N … Bosman FT (European journal of biochemistry 1995) 2 3 4 22 60
  2. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PMID: 20186120) Richter R … Chrzanowska-Lightowlers ZM (The EMBO journal 2010) 2 3 4 60
  3. Human Cells Require Non-stop Ribosome Rescue Activity in Mitochondria. (PMID: 27029019) Feaga HA … Keiler KC (PLoS genetics 2016) 2 3 60
  4. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 60
  5. Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome. (PMID: 23908630) Koc EC … Koc H (Frontiers in physiology 2013) 3 4 60

Products for MRPL58 Gene

Sources for MRPL58 Gene

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