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Aliases for MRPL57 Gene

Aliases for MRPL57 Gene

  • Mitochondrial Ribosomal Protein L57 2 3 4
  • Mitochondrial Ribosomal Protein 63 2 3 4
  • MRP63 3 4 6
  • HMRP63 3 4
  • Mitochondrial Ribosomal Protein BMRP63 3
  • Ribosomal Protein 63, Mitochondrial 3
  • BMRP63 3

External Ids for MRPL57 Gene

Previous HGNC Symbols for MRPL57 Gene

  • MRP63

Previous GeneCards Identifiers for MRPL57 Gene

  • GC13P021751

Summaries for MRPL57 Gene

Entrez Gene Summary for MRPL57 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein which belongs to an undetermined ribosomal subunit and which seems to be specific to animal mitoribosomes. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 3p, 5q, 8q, 14q, and Y. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL57 Gene

MRPL57 (Mitochondrial Ribosomal Protein L57) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL57 Gene

Genomics for MRPL57 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPL57 Gene

21,176,233 bp from pter
21,179,084 bp from pter
2,852 bases
Plus strand

Genomic View for MRPL57 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL57 Gene

No data available for Regulatory Elements for MRPL57 Gene

Proteins for MRPL57 Gene

  • Protein details for MRPL57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosomal protein 63, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A2A332

    Protein attributes for MRPL57 Gene

    102 amino acids
    Molecular mass:
    12266 Da
    Quaternary structure:
    No Data Available
    • Identified only in the intact 55S subunit. It is unknown whether it belongs to the 28S or to the 39S subunit. May localize at the subunit interface and dissociate from the 55S mitoribosome during subunit separation

    Three dimensional structures from OCA and Proteopedia for MRPL57 Gene

neXtProt entry for MRPL57 Gene

Proteomics data for MRPL57 Gene at MOPED

Post-translational modifications for MRPL57 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL57 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL57 Gene

Domains for MRPL57 Gene

Gene Families for MRPL57 Gene

Protein Domains for MRPL57 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPL57: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MRPL57 Gene

Function for MRPL57 Gene

Gene Ontology (GO) - Molecular Function for MRPL57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IEA --
genes like me logo Genes that share ontologies with MRPL57: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL57

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRPL57 Gene

Localization for MRPL57 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL57 Gene


Gene Ontology (GO) - Cellular Components for MRPL57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005761 mitochondrial ribosome IEA --
genes like me logo Genes that share ontologies with MRPL57: view

No data available for Subcellular locations from COMPARTMENTS for MRPL57 Gene

Pathways for MRPL57 Gene

SuperPathways for MRPL57 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRPL57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
genes like me logo Genes that share ontologies with MRPL57: view

No data available for Pathways by source for MRPL57 Gene

Transcripts for MRPL57 Gene

mRNA/cDNA for MRPL57 Gene

(87) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL57

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL57 Gene

No ASD Table

Relevant External Links for MRPL57 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL57 Gene

mRNA expression in normal human tissues for MRPL57 Gene

Protein differential expression in normal tissues for MRPL57 Gene

This gene is overexpressed in Pancreas (18.0), Peripheral blood mononuclear cells (11.4), and Breast (10.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MRPL57 Gene

genes like me logo Genes that share expressions with MRPL57: view

Expression partners for MRPL57 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL57 Gene

Orthologs for MRPL57 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPL57 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRP63 35
  • 81.37 (n)
  • 80.39 (a)
MRP63 36
  • 80 (a)
(Canis familiaris)
Mammalia MRP63 35
  • 84.16 (n)
  • 82.18 (a)
-- 36
  • 60 (a)
-- 36
  • 82 (a)
(Mus musculus)
Mammalia Mrp63 35
  • 82.35 (n)
  • 83.33 (a)
Mrp63 16
Mrp63 36
  • 83 (a)
(Pan troglodytes)
Mammalia MRP63 35
  • 99.02 (n)
  • 99.02 (a)
MRP63 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mrp63 35
  • 82.68 (n)
  • 84.31 (a)
(Monodelphis domestica)
Mammalia MRP63 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia MRP63 36
  • 72 (a)
(Gallus gallus)
Aves MRP63 35
  • 60.78 (n)
  • 61.76 (a)
(Anolis carolinensis)
Reptilia MRP63 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491945 35
  • 62.75 (n)
  • 62.75 (a)
(Danio rerio)
Actinopterygii mrpl57 35
  • 61.06 (n)
  • 62.38 (a)
mrp63 36
  • 55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12294 35
Species with no ortholog for MRPL57:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL57 Gene

Gene Tree for MRPL57 (if available)
Gene Tree for MRPL57 (if available)

Paralogs for MRPL57 Gene Pseudogenes for MRPL57 Gene

genes like me logo Genes that share paralogs with MRPL57: view

No data available for Paralogs for MRPL57 Gene

Variants for MRPL57 Gene

Sequence variations from dbSNP and Humsavar for MRPL57 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs577471158 -- 21,178,693(+) GCTTA(C/G)GCCTG utr-variant-3-prime
rs570681734 -- 21,178,983(+) ATATA(A/G)TAATA utr-variant-3-prime
rs564118659 -- 21,179,532(+) ATCAC(C/T)TGAAC downstream-variant-500B
rs560166913 -- 21,178,974(+) AAAAA(-/ATAC)ATATA utr-variant-3-prime
rs559165136 -- 21,178,678(+) TAGCC(A/G)GGCGT utr-variant-3-prime

Relevant External Links for MRPL57 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPL57 Gene

Disorders for MRPL57 Gene

No disorders were found for MRPL57 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for MRPL57 Gene

Publications for MRPL57 Gene

  1. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PMID: 11402041) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome. (PMID: 23908630) Koc E.C. … Koc H. (Front. Physiol. 2013) 2 3
  4. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 4
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4

Products for MRPL57 Gene

Sources for MRPL57 Gene

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