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Aliases for MRPL57 Gene

Aliases for MRPL57 Gene

  • Mitochondrial Ribosomal Protein L57 2 3 4 5
  • Mitochondrial Ribosomal Protein 63 2 3 4
  • HMRP63 3 4
  • MRP63 3 4
  • Mitochondrial Ribosomal Protein BMRP63 3
  • BMRP63 3

External Ids for MRPL57 Gene

Previous HGNC Symbols for MRPL57 Gene

  • MRP63

Previous GeneCards Identifiers for MRPL57 Gene

  • GC13P021751

Summaries for MRPL57 Gene

Entrez Gene Summary for MRPL57 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein which belongs to an undetermined ribosomal subunit and which seems to be specific to animal mitoribosomes. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 3p, 5q, 8q, 14q, and Y. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL57 Gene

MRPL57 (Mitochondrial Ribosomal Protein L57) is a Protein Coding gene. GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL57 Gene

Genomics for MRPL57 Gene

Regulatory Elements for MRPL57 Gene

Enhancers for MRPL57 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPL57 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL57 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL57 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL57 Gene

21,176,233 bp from pter
21,179,084 bp from pter
2,852 bases
Plus strand

Genomic View for MRPL57 Gene

Genes around MRPL57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL57 Gene

Proteins for MRPL57 Gene

  • Protein details for MRPL57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ribosomal protein 63, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A2A332

    Protein attributes for MRPL57 Gene

    102 amino acids
    Molecular mass:
    12266 Da
    Quaternary structure:
    No Data Available
    • Identified only in the intact 55S subunit. It is unknown whether it belongs to the 28S or to the 39S subunit. May localize at the subunit interface and dissociate from the 55S mitoribosome during subunit separation.

    Three dimensional structures from OCA and Proteopedia for MRPL57 Gene

neXtProt entry for MRPL57 Gene

Proteomics data for MRPL57 Gene at MOPED

Post-translational modifications for MRPL57 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL57 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL57 Gene

Domains & Families for MRPL57 Gene

Gene Families for MRPL57 Gene

Protein Domains for MRPL57 Gene


Suggested Antigen Peptide Sequences for MRPL57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPL57: view

No data available for UniProtKB/Swiss-Prot for MRPL57 Gene

Function for MRPL57 Gene

Phenotypes for MRPL57 Gene

genes like me logo Genes that share phenotypes with MRPL57: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRPL57 Gene

Localization for MRPL57 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL57 Gene


Gene Ontology (GO) - Cellular Components for MRPL57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with MRPL57: view

No data available for Subcellular locations from COMPARTMENTS for MRPL57 Gene

Pathways & Interactions for MRPL57 Gene

SuperPathways for MRPL57 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRPL57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032543 mitochondrial translation ISS 11402041
genes like me logo Genes that share ontologies with MRPL57: view

No data available for Pathways by source and SIGNOR curated interactions for MRPL57 Gene

Drugs & Compounds for MRPL57 Gene

No Compound Related Data Available

Transcripts for MRPL57 Gene

mRNA/cDNA for MRPL57 Gene

(1) REFSEQ mRNAs :
(87) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL57 Gene

No ASD Table

Relevant External Links for MRPL57 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL57 Gene

mRNA expression in normal human tissues for MRPL57 Gene

Protein differential expression in normal tissues from HIPED for MRPL57 Gene

This gene is overexpressed in Pancreas (18.0), Peripheral blood mononuclear cells (11.4), and Breast (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MRPL57 Gene

genes like me logo Genes that share expression patterns with MRPL57: view

Protein tissue co-expression partners for MRPL57 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL57 Gene

Orthologs for MRPL57 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPL57 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRP63 35
  • 81.37 (n)
  • 80.39 (a)
MRP63 36
  • 80 (a)
(Canis familiaris)
Mammalia MRP63 35
  • 84.16 (n)
  • 82.18 (a)
-- 36
  • 60 (a)
-- 36
  • 82 (a)
(Mus musculus)
Mammalia Mrp63 35
  • 82.35 (n)
  • 83.33 (a)
Mrpl57 16
Mrp63 36
  • 83 (a)
(Pan troglodytes)
Mammalia MRP63 35
  • 99.02 (n)
  • 99.02 (a)
MRP63 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mrp63 35
  • 82.68 (n)
  • 84.31 (a)
(Monodelphis domestica)
Mammalia MRP63 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia MRP63 36
  • 72 (a)
(Gallus gallus)
Aves MRP63 35
  • 60.78 (n)
  • 61.76 (a)
(Anolis carolinensis)
Reptilia MRP63 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491945 35
  • 62.75 (n)
  • 62.75 (a)
(Danio rerio)
Actinopterygii mrpl57 35
  • 61.06 (n)
  • 62.38 (a)
mrp63 36
  • 55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12294 35
Species with no ortholog for MRPL57:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL57 Gene

Gene Tree for MRPL57 (if available)
Gene Tree for MRPL57 (if available)

Paralogs for MRPL57 Gene Pseudogenes for MRPL57 Gene

genes like me logo Genes that share paralogs with MRPL57: view

No data available for Paralogs for MRPL57 Gene

Variants for MRPL57 Gene

Sequence variations from dbSNP and Humsavar for MRPL57 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1137024 -- 21,178,921(-) gcacg(A/C)tctca utr-variant-3-prime
rs1137025 -- 21,178,916(-) ATCTC(A/G)GCTCA utr-variant-3-prime
rs1137026 -- 21,178,885(-) gttca(A/G)gcaat utr-variant-3-prime
rs1137027 -- 21,178,882(-) CAAGC(A/G)ATTCT utr-variant-3-prime
rs1137028 -- 21,178,879(-) GCAAT(C/T)CTCCT utr-variant-3-prime

Variation tolerance for MRPL57 Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for MRPL57 Gene

Disorders for MRPL57 Gene

Relevant External Links for MRPL57

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPL57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL57 Gene

Publications for MRPL57 Gene

  1. Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome. (PMID: 23908630) Koc E.C. … Koc H. (Front. Physiol. 2013) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3

Products for MRPL57 Gene

Sources for MRPL57 Gene