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Aliases for MRPL57 Gene

Aliases for MRPL57 Gene

  • Mitochondrial Ribosomal Protein L57 2 3 4 5
  • Mitochondrial Ribosomal Protein 63 2 3 4
  • Mitochondrial Large Ribosomal Subunit Protein ML63 3 4
  • HMRP63 3 4
  • MRP63 3 4
  • Mitochondrial Ribosomal Protein BMRP63 3
  • Ribosomal Protein 63, Mitochondrial 3
  • BMRP63 3

External Ids for MRPL57 Gene

Previous HGNC Symbols for MRPL57 Gene

  • MRP63

Previous GeneCards Identifiers for MRPL57 Gene

  • GC13P021751

Summaries for MRPL57 Gene

Entrez Gene Summary for MRPL57 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein which belongs to an undetermined ribosomal subunit and which seems to be specific to animal mitoribosomes. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 3p, 5q, 8q, 14q, and Y. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL57 Gene

MRPL57 (Mitochondrial Ribosomal Protein L57) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include structural constituent of ribosome.

Additional gene information for MRPL57 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL57 Gene

Genomics for MRPL57 Gene

Regulatory Elements for MRPL57 Gene

Enhancers for MRPL57 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H021139 1.1 ENCODE 12.6 -35.7 -35708 2 HDGF ATF1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 BRCA1 YY1 IPPKP1 LINC01046 LATS2-AS1 LINC00367 CNOT4P1 MRPL57 SKA3 SAP18 GC13M021142
GH13H021296 1.1 ENCODE 10.8 +122.0 122016 2 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 FOS MRPL57 SKA3 GRK6P1 LINC00539 MIPEPP3
GH13H021032 1.1 Ensembl ENCODE dbSUPER 10.6 -142.2 -142152 2 CTCF MAX MNT FEZF1 NR3C1 RAD21 OSR2 SMC3 MYC LATS2 LATS2-AS1 SAP18 ENSG00000252128 SKA3 MRPL57 CRYL1 GC13M021039 RNU4-9P
GH13H021038 1.1 Ensembl ENCODE dbSUPER 10.6 -136.3 -136318 3 JUN BCL11A ZNF341 IKZF1 GLIS1 ETV6 IKZF2 SPI1 ZNF18 LATS2 LATS2-AS1 ENSG00000252128 SAP18 MRPL57 SKA3 CRYL1 RNU4-9P GC13M021039
GH13H021217 0.9 ENCODE dbSUPER 12.3 +42.8 42812 3 PKNOX1 CBFB EBF1 DPF2 ZNF366 POLR2A IKZF1 EED MLLT1 RUNX3 MRPL57 SKA3 SAP18 ENSG00000271250 LINC01046
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL57 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL57 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000059761 267 2201 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143

Genomic Location for MRPL57 Gene

Chromosome:
13
Start:
21,176,233 bp from pter
End:
21,179,084 bp from pter
Size:
2,852 bases
Orientation:
Plus strand

Genomic View for MRPL57 Gene

Genes around MRPL57 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL57 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL57 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL57 Gene

Proteins for MRPL57 Gene

  • Protein details for MRPL57 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQC6-RT63_HUMAN
    Recommended name:
    Ribosomal protein 63, mitochondrial
    Protein Accession:
    Q9BQC6
    Secondary Accessions:
    • A2A332

    Protein attributes for MRPL57 Gene

    Size:
    102 amino acids
    Molecular mass:
    12266 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

    Three dimensional structures from OCA and Proteopedia for MRPL57 Gene

neXtProt entry for MRPL57 Gene

Post-translational modifications for MRPL57 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL57 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL57 Gene

Domains & Families for MRPL57 Gene

Gene Families for MRPL57 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MRPL57 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL57 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BQC6

UniProtKB/Swiss-Prot:

RT63_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mL63 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mL63 family.
genes like me logo Genes that share domains with MRPL57: view

Function for MRPL57 Gene

Gene Ontology (GO) - Molecular Function for MRPL57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome ISS 11402041
genes like me logo Genes that share ontologies with MRPL57: view

Phenotypes for MRPL57 Gene

genes like me logo Genes that share phenotypes with MRPL57: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MRPL57
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRPL57 Gene

Localization for MRPL57 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL57 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL57 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPL57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome ISS 11402041
GO:0005840 ribosome IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MRPL57: view

Pathways & Interactions for MRPL57 Gene

genes like me logo Genes that share pathways with MRPL57: view

Gene Ontology (GO) - Biological Process for MRPL57 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA --
GO:0032543 mitochondrial translation ISS 11402041
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL57: view

No data available for SIGNOR curated interactions for MRPL57 Gene

Drugs & Compounds for MRPL57 Gene

No Compound Related Data Available

Transcripts for MRPL57 Gene

mRNA/cDNA for MRPL57 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MRPL57
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL57 Gene

No ASD Table

Relevant External Links for MRPL57 Gene

GeneLoc Exon Structure for
MRPL57
ECgene alternative splicing isoforms for
MRPL57

Expression for MRPL57 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL57 Gene

Protein differential expression in normal tissues from HIPED for MRPL57 Gene

This gene is overexpressed in Pancreas (18.0), Peripheral blood mononuclear cells (11.4), and Breast (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL57 Gene



Protein tissue co-expression partners for MRPL57 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL57 Gene:

MRPL57

Evidence on tissue expression from TISSUES for MRPL57 Gene

  • Nervous system(4.3)
  • Eye(4.2)
genes like me logo Genes that share expression patterns with MRPL57: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL57 Gene

Orthologs for MRPL57 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPL57 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRP63 34 33
  • 99.02 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MRP63 33
  • 84.16 (n)
-- 34
  • 82 (a)
OneToMany
-- 34
  • 60 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mrp63 33
  • 82.68 (n)
mouse
(Mus musculus)
Mammalia Mrp63 34 33
  • 82.35 (n)
OneToOne
Mrpl57 16
cow
(Bos Taurus)
Mammalia MRP63 33 34
  • 81.37 (n)
oppossum
(Monodelphis domestica)
Mammalia MRP63 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRP63 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRP63 33
  • 60.78 (n)
lizard
(Anolis carolinensis)
Reptilia MRP63 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491945 33
  • 62.75 (n)
zebrafish
(Danio rerio)
Actinopterygii mrpl57 33
  • 61.06 (n)
mrp63 34
  • 55 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12294 33
Species where no ortholog for MRPL57 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL57 Gene

ENSEMBL:
Gene Tree for MRPL57 (if available)
TreeFam:
Gene Tree for MRPL57 (if available)

Paralogs for MRPL57 Gene

Pseudogenes.org Pseudogenes for MRPL57 Gene

genes like me logo Genes that share paralogs with MRPL57: view

No data available for Paralogs for MRPL57 Gene

Variants for MRPL57 Gene

Sequence variations from dbSNP and Humsavar for MRPL57 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000055454 -- 21,174,738(+) ATTTT(A/T)AAAAA intron-variant, upstream-variant-2KB
rs1000835557 -- 21,177,917(+) TGAAG(C/T)GGAGG downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1001108435 -- 21,177,333(+) CCAGT(C/T)TTTAT upstream-variant-2KB, utr-variant-3-prime
rs1001287785 -- 21,177,699(+) GTGCG(A/G)TGGCT downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1001517484 -- 21,177,331(+) GACCA(C/G)TCTTT upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPL57 Gene

Variant ID Type Subtype PubMed ID
esv3631456 CNV loss 21293372
nsv1037082 CNV gain 25217958
nsv1078303 OTHER inversion 25765185
nsv1115634 CNV deletion 24896259
nsv1140246 OTHER inversion 24896259
nsv1151909 OTHER inversion 26484159
nsv1152114 CNV deletion 26484159

Variation tolerance for MRPL57 Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.99; 20.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL57 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL57

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL57 Gene

Disorders for MRPL57 Gene

Relevant External Links for MRPL57

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL57

No disorders were found for MRPL57 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL57 Gene

Publications for MRPL57 Gene

  1. Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome. (PMID: 23908630) Koc EC … Koc H (Frontiers in physiology 2013) 2 3 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit. (PMID: 11402041) Suzuki T … Watanabe K (The Journal of biological chemistry 2001) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 60

Products for MRPL57 Gene

Sources for MRPL57 Gene

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