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Aliases for MRPL55 Gene

Aliases for MRPL55 Gene

  • Mitochondrial Ribosomal Protein L55 2 3
  • MRP-L55 3 4
  • L55mt 3 4
  • 39S Ribosomal Protein L55, Mitochondrial 3
  • AAVG5835 3
  • PRO19675 3
  • L55nt 3

External Ids for MRPL55 Gene

Previous GeneCards Identifiers for MRPL55 Gene

  • GC01U990459
  • GC01M224679
  • GC01M225269
  • GC01M224601
  • GC01M226361
  • GC01M228294
  • GC01M198809

Summaries for MRPL55 Gene

Entrez Gene Summary for MRPL55 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding two different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL55 Gene

MRPL55 (Mitochondrial Ribosomal Protein L55) is a Protein Coding gene. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL55 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL55 Gene

Genomics for MRPL55 Gene

Regulatory Elements for MRPL55 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPL55 Gene

Start:
228,106,679 bp from pter
End:
228,109,337 bp from pter
Size:
2,659 bases
Orientation:
Minus strand

Genomic View for MRPL55 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL55 Gene

Proteins for MRPL55 Gene

  • Protein details for MRPL55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7F7-RM55_HUMAN
    Recommended name:
    39S ribosomal protein L55, mitochondrial
    Protein Accession:
    Q7Z7F7
    Secondary Accessions:
    • Q5TBY3
    • Q5TBY6
    • Q6UWI8

    Protein attributes for MRPL55 Gene

    Size:
    128 amino acids
    Molecular mass:
    15128 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
    SequenceCaution:
    • Sequence=CAI23115.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23118.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MRPL55 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL55 Gene

Proteomics data for MRPL55 Gene at MOPED

Post-translational modifications for MRPL55 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRPL55 Gene

Domains for MRPL55 Gene

Gene Families for MRPL55 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL55 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL55 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPL55: view

No data available for UniProtKB/Swiss-Prot for MRPL55 Gene

Function for MRPL55 Gene

Gene Ontology (GO) - Molecular Function for MRPL55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome ISS --
genes like me logo Genes that share ontologies with MRPL55: view

Phenotypes for MRPL55 Gene

GenomeRNAi human phenotypes for MRPL55:
genes like me logo Genes that share phenotypes with MRPL55: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MRPL55 Gene

Localization for MRPL55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL55 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL55 Gene COMPARTMENTS Subcellular localization image for MRPL55 gene
Compartment Confidence
mitochondrion 4
extracellular 2
nucleus 2
cytosol 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MRPL55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit ISS --
genes like me logo Genes that share ontologies with MRPL55: view

Pathways for MRPL55 Gene

SuperPathways for MRPL55 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRPL55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation ISS --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL55: view

No data available for Pathways by source for MRPL55 Gene

Transcripts for MRPL55 Gene

Unigene Clusters for MRPL55 Gene

Mitochondrial ribosomal protein L55:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL55

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL55 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g
SP1: -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - -
SP11:
SP12: - -
SP13: - - - - - -
SP14: - - - -
SP15: - -
SP16: - -
SP17: - -

Relevant External Links for MRPL55 Gene

GeneLoc Exon Structure for
MRPL55
ECgene alternative splicing isoforms for
MRPL55

Expression for MRPL55 Gene

mRNA expression in normal human tissues for MRPL55 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL55 Gene

SOURCE GeneReport for Unigene cluster for MRPL55 Gene Hs.63236

genes like me logo Genes that share expressions with MRPL55: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL55 Gene

Orthologs for MRPL55 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL55 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL55 35
  • 99.48 (n)
  • 98.44 (a)
MRPL55 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL55 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL55 35
  • 76.96 (n)
  • 75.61 (a)
MRPL55 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl55 35
  • 76.27 (n)
  • 72.8 (a)
Mrpl55 16
Mrpl55 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL55 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl55 35
  • 77.07 (n)
  • 74.4 (a)
chicken
(Gallus gallus)
Aves MRPL55 35
  • 62.5 (n)
  • 49.11 (a)
MRPL55 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL55 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl55 35
  • 54.4 (n)
  • 46.4 (a)
zebrafish
(Danio rerio)
Actinopterygii MRPL55 36
  • 38 (a)
OneToOne
zgc:171480 35
  • 53.07 (n)
  • 48.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL55 36
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7221 36
  • 24 (a)
OneToOne
Species with no ortholog for MRPL55:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL55 Gene

ENSEMBL:
Gene Tree for MRPL55 (if available)
TreeFam:
Gene Tree for MRPL55 (if available)

Paralogs for MRPL55 Gene

No data available for Paralogs for MRPL55 Gene

Variants for MRPL55 Gene

Sequence variations from dbSNP and Humsavar for MRPL55 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs11706 -- 228,107,780(-) GGCCT(C/T)ACTCA reference, missense
rs822729 -- 228,109,142(-) TTGGC(G/T)CCTCG intron-variant, upstream-variant-2KB
rs822730 - 228,107,826(-) CACTC(C/T)GCCGC reference, missense
rs849749 -- 228,109,044(-) CCTGT(A/G)ATAAG intron-variant, utr-variant-5-prime
rs1620734 -- 228,109,912(-) TCCTC(C/T)CTCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRPL55 Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV Gain 17666407
nsv826908 CNV Gain 20364138
nsv516409 CNV Loss 19592680
nsv523935 CNV Loss 19592680
nsv832803 CNV Loss 17160897
nsv873252 CNV Loss 21882294
dgv537n71 CNV Loss 21882294
nsv873255 CNV Loss 21882294
nsv482143 CNV Gain 20164927

Relevant External Links for MRPL55 Gene

HapMap Linkage Disequilibrium report
MRPL55

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL55 Gene

Disorders for MRPL55 Gene

Relevant External Links for MRPL55

Genetic Association Database (GAD)
MRPL55
Human Genome Epidemiology (HuGE) Navigator
MRPL55
genes like me logo Genes that share disorders with MRPL55: view

No data available for UniProtKB/Swiss-Prot for MRPL55 Gene

Publications for MRPL55 Gene

  1. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 3 4
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48

Products for MRPL55 Gene

Sources for MRPL55 Gene

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