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Aliases for MRPL55 Gene

Aliases for MRPL55 Gene

  • Mitochondrial Ribosomal Protein L55 2 3 5
  • MRP-L55 3 4
  • L55mt 3 4
  • AAVG5835 3
  • PRO19675 3
  • L55nt 3

External Ids for MRPL55 Gene

Previous GeneCards Identifiers for MRPL55 Gene

  • GC01U990459
  • GC01M224679
  • GC01M225269
  • GC01M224601
  • GC01M226361
  • GC01M228294
  • GC01M198809

Summaries for MRPL55 Gene

Entrez Gene Summary for MRPL55 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding two different isoforms were identified through sequence analysis. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL55 Gene

MRPL55 (Mitochondrial Ribosomal Protein L55) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPL55 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL55 Gene

Genomics for MRPL55 Gene

Regulatory Elements for MRPL55 Gene

Enhancers for MRPL55 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPL55 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL55 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL55 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL55 Gene

228,106,679 bp from pter
228,110,953 bp from pter
4,275 bases
Minus strand

Genomic View for MRPL55 Gene

Genes around MRPL55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL55 Gene

Proteins for MRPL55 Gene

  • Protein details for MRPL55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L55, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q5TBY3
    • Q5TBY6
    • Q6UWI8

    Protein attributes for MRPL55 Gene

    128 amino acids
    Molecular mass:
    15128 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins.
    • Sequence=CAI23115.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI23118.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL55 Gene

    Alternative splice isoforms for MRPL55 Gene


neXtProt entry for MRPL55 Gene

Proteomics data for MRPL55 Gene at MOPED

Post-translational modifications for MRPL55 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MRPL55 Gene

Domains & Families for MRPL55 Gene

Gene Families for MRPL55 Gene

Protein Domains for MRPL55 Gene


Suggested Antigen Peptide Sequences for MRPL55 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPL55: view

No data available for UniProtKB/Swiss-Prot for MRPL55 Gene

Function for MRPL55 Gene

genes like me logo Genes that share phenotypes with MRPL55: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MRPL55 Gene

Localization for MRPL55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL55 Gene


Subcellular locations from

Jensen Localization Image for MRPL55 Gene COMPARTMENTS Subcellular localization image for MRPL55 gene
Compartment Confidence
mitochondrion 5
extracellular 2
golgi apparatus 2
nucleus 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MRPL55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPL55: view

Pathways & Interactions for MRPL55 Gene

genes like me logo Genes that share pathways with MRPL55: view

Gene Ontology (GO) - Biological Process for MRPL55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation ISS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPL55: view

No data available for SIGNOR curated interactions for MRPL55 Gene

Drugs & Compounds for MRPL55 Gene

No Compound Related Data Available

Transcripts for MRPL55 Gene

Unigene Clusters for MRPL55 Gene

Mitochondrial ribosomal protein L55:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL55 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b · 8c · 8d · 8e · 8f · 8g
SP1: -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - - - -
SP9: - - - - - - - - - -
SP10: - - - - - - - - -
SP12: - -
SP13: - - - - - -
SP14: - - - -
SP15: - -
SP16: - -
SP17: - -

Relevant External Links for MRPL55 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL55 Gene

mRNA expression in normal human tissues for MRPL55 Gene

Protein differential expression in normal tissues from HIPED for MRPL55 Gene

This gene is overexpressed in Lung (23.8), Breast (21.2), Peripheral blood mononuclear cells (9.5), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL55 Gene

SOURCE GeneReport for Unigene cluster for MRPL55 Gene Hs.63236

genes like me logo Genes that share expression patterns with MRPL55: view

Protein tissue co-expression partners for MRPL55 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL55 Gene

Orthologs for MRPL55 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL55 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia MRPL55 35
  • 76.96 (n)
  • 75.61 (a)
MRPL55 36
  • 74 (a)
(Mus musculus)
Mammalia Mrpl55 35
  • 76.27 (n)
  • 72.8 (a)
Mrpl55 16
Mrpl55 36
  • 72 (a)
(Pan troglodytes)
Mammalia MRPL55 35
  • 99.48 (n)
  • 98.44 (a)
MRPL55 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Mrpl55 35
  • 77.07 (n)
  • 74.4 (a)
(Bos Taurus)
Mammalia MRPL55 36
  • 68 (a)
(Monodelphis domestica)
Mammalia MRPL55 36
  • 59 (a)
(Gallus gallus)
Aves MRPL55 35
  • 62.5 (n)
  • 49.11 (a)
MRPL55 36
  • 45 (a)
(Anolis carolinensis)
Reptilia MRPL55 36
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl55 35
  • 54.4 (n)
  • 46.4 (a)
(Danio rerio)
Actinopterygii zgc:171480 35
  • 53.07 (n)
  • 48.54 (a)
MRPL55 36
  • 38 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL55 36
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7221 36
  • 24 (a)
Species with no ortholog for MRPL55:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL55 Gene

Gene Tree for MRPL55 (if available)
Gene Tree for MRPL55 (if available)

Paralogs for MRPL55 Gene

No data available for Paralogs for MRPL55 Gene

Variants for MRPL55 Gene

Sequence variations from dbSNP and Humsavar for MRPL55 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs822730 - 228,107,826(-) CACTC(C/T)GCCGC nc-transcript-variant, reference, missense
rs35265990 - 228,107,771(+) GCACA(C/T)GAGTG nc-transcript-variant, reference, missense
rs11706 -- 228,107,780(-) GGCCT(C/T)ACTCA nc-transcript-variant, reference, missense
rs822729 -- 228,109,142(-) TTGGC(G/T)CCTCG intron-variant
rs849749 -- 228,109,044(-) CCTGT(A/G)ATAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL55 Gene

Variant ID Type Subtype PubMed ID
esv32853 CNV Gain 17666407
nsv826908 CNV Gain 20364138
nsv516409 CNV Loss 19592680
nsv523935 CNV Loss 19592680
nsv832803 CNV Loss 17160897
nsv873252 CNV Loss 21882294
dgv537n71 CNV Loss 21882294
nsv873255 CNV Loss 21882294
nsv482143 CNV Gain 20164927

Variation tolerance for MRPL55 Gene

Residual Variation Intolerance Score: 73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.37% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRPL55 Gene

Disorders for MRPL55 Gene

Relevant External Links for MRPL55

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPL55 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL55 Gene

Publications for MRPL55 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for MRPL55 Gene

Sources for MRPL55 Gene