MRPL54 Gene
protein-coding GIFtS: 41
GCID: GC19P003762
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mitochondrial ribosomal protein L54
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Aliases
for MRPL54 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein L541 2 | | L54mt2 3 | | MRP-L542 3 | | 39S Ribosomal Protein L54, Mitochondrial2 |
Export aliases for MRPL54 gene to outside databasesPrevious GC identifers: GC19U990297 GC19P003702 GC19P003713 GC19P003527 |
Summaries
for MRPL54 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPL54:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.(provided by RefSeq, Jul 2008)
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Genomic Views
for MRPL54 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPL54 gene promoter:
Max1 NF-1 NF-1/L AML1a p300 AP-2gamma AP-2beta AP-2alpha AP-2alphaA c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPL54
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL54 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3MRPL54 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P003762: view genomic region
(about GC identifiers)
Start:
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3,762,662 bp from pter |
End:
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3,768,573 bp from pter |
Size:
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5,912 bases |
Orientation:
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plus strand |
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Proteins
for MRPL54 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RM54_HUMAN, Q6P161 (See
protein sequence)Recommended Name: 39S ribosomal protein L54, mitochondrial precursor Size: 138 amino acids; 15819 Da
Subcellular location: Mitochondrion (By similarity)Explore the universe of human proteins at neXtProt for MRPL54: NX_Q6P161
MRPL54 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_758455.1
ENSEMBL proteins: ENSP00000331849 ENSP00000467023
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MRPL54 for ontologies About GeneDecksing
MRPL54 Antibody Products:
Assay Products for MRPL54: |
Protein
Domains /
Families
for MRPL54 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPL54 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6P161ProtoNet protein and cluster: Q6P161 |
Function
for MRPL54 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL54 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL54
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: MRPL54 (NM_172251) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL54 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL54 |
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Mrpl54):
MRPL54 for phenotypes About GeneDecksing
|
Pathways & Interactions
for MRPL54 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL54
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/231 Interacting proteins for MRPL54 (Q6P1612, 3 ENSP000003318494) via UniProtKB, MINT, STRING, and/or I2D (see all 231)About this table
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Drugs & Compounds
for MRPL54 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPL54
Search CenterWatch for drugs/clinical trials and news about MRPL54 / RM54
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Transcripts
for MRPL54 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPL54 gene: NM_172251.2 Unigene Cluster for MRPL54: Mitochondrial ribosomal protein L54 Hs.356578 [show with all ESTs]Unigene Representative Sequence: BM9206722 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000330133(uc002lyq.4) ENST00000589174
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL54 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL54
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRPL54 (NM_172251) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL54 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL54 |
Additional cDNA sequence: BC065273.1 2 DOTS entries: DT.414886 DT.100751845 24/126 AceView cDNA sequences (see all 126): AA318567 AJ346576 BM792364 BM796855 AA602313 BQ683417 BM704938 BM788514 BE858454 AA482135 BQ061807 CB054573 AJ278551 BM550737 AJ713530 AI580130 BM856529 CB046008 BG394230 AA430119 CA448108 BC065273 CF127233 F18758
GeneLoc Exon Structure
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Expression
for MRPL54 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPL54 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGACCCCACA
About this image
See MRPL54 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPL54
SOURCE GeneReport for Unigene cluster: Hs.356578
SABiosciences Custom PCR Arrays for MRPL54
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL54
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL54 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL54 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL54 |
Orthologs
for MRPL54 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MRPL54 gene from 6/17 species (see all 17) About this table
ENSEMBL Gene Tree for MRPL54 (if available)
TreeFam Gene Tree for MRPL54 (if available) |
Paralogs
for MRPL54 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRPL54 gene
MRPL54 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MRPL54
PGOHUM00000247795
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Genomic Variants
for MRPL54 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for MRPL54 (3762662 - 3768573 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for MRPL54
1 CNV: 30067 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL54 |
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Disorders
/ Diseases
for MRPL54 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRPL54 for disorders About MalaCards
MRPL54 for disorders About GeneDecksing
OMIM gene information: 611858
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MRPL54 (1 document)
Export disorders for MRPL54 gene to outside databases
|
Publications
for MRPL54 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPL54 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with MRPL54) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PubMed id 11551941)1, 3 Koc E.C....Spremulli L.L. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. (PubMed id 12706105)1 Zhang Z. and Gerstein M. (2003)
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External Searches for MRPL54 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MRPL54 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing MRPL54 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPL54 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPL54 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MRPL54 gene:
Search GeneIP for patents involving MRPL54
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPL54 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRPL54 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPL54 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL54 | | | OriGene Protein Over-expression Lysate for MRPL54 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for MRPL54 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL54 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL54 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MRPL54 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MRPL54 | | OriGene Custom Protein Services for MRPL54 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPL54 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL54 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL54 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPL54 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL54 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL54 |
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| | | | Search Tocris compounds for MRPL54 |
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 | | | MRPL54 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for MRPL54 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL54 |
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