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Aliases for MRPL54 Gene

Aliases for MRPL54 Gene

  • Mitochondrial Ribosomal Protein L54 2 3
  • MRP-L54 3 4
  • L54mt 3 4
  • 39S Ribosomal Protein L54, Mitochondrial 3

External Ids for MRPL54 Gene

Summaries for MRPL54 Gene

Entrez Gene Summary for MRPL54 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL54 Gene

MRPL54 (Mitochondrial Ribosomal Protein L54) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL54 Gene

Genomics for MRPL54 Gene

Genomic Location for MRPL54 Gene

Start:
3,762,664 bp from pter
End:
3,768,575 bp from pter
Size:
5,912 bases
Orientation:
Plus strand

Genomic View for MRPL54 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL54 Gene

Regulatory Elements for MRPL54 Gene

Proteins for MRPL54 Gene

  • Protein details for MRPL54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P161-RM54_HUMAN
    Recommended name:
    39S ribosomal protein L54, mitochondrial
    Protein Accession:
    Q6P161
    Secondary Accessions:

    Protein attributes for MRPL54 Gene

    Size:
    138 amino acids
    Molecular mass:
    15819 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MRPL54 Gene

Proteomics data for MRPL54 Gene at MOPED

Post-translational modifications for MRPL54 Gene

No Post-translational modifications

Other Protein References for MRPL54 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL54 Gene

Domains for MRPL54 Gene

Gene Families for MRPL54 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL54 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL54 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPL54: view

No data available for UniProtKB/Swiss-Prot for MRPL54 Gene

Function for MRPL54 Gene

Gene Ontology (GO) - Molecular Function for MRPL54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with MRPL54: view
genes like me logo Genes that share phenotypes with MRPL54: view

miRNA for MRPL54 Gene

miRTarBase miRNAs that target MRPL54

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL54 Gene

Localization for MRPL54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL54 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL54 Gene COMPARTMENTS Subcellular localization image for MRPL54 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL54: view

Pathways for MRPL54 Gene

SuperPathways for MRPL54 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRPL54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL54: view

No data available for Pathways by source for MRPL54 Gene

Transcripts for MRPL54 Gene

mRNA/cDNA for MRPL54 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(126) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRPL54 Gene

Mitochondrial ribosomal protein L54:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL54 Gene

No ASD Table

Relevant External Links for MRPL54 Gene

GeneLoc Exon Structure for
MRPL54
ECgene alternative splicing isoforms for
MRPL54

Expression for MRPL54 Gene

mRNA expression in normal human tissues for MRPL54 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL54 Gene

SOURCE GeneReport for Unigene cluster for MRPL54 Gene Hs.356578

genes like me logo Genes that share expressions with MRPL54: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL54 Gene

Orthologs for MRPL54 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL54 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL54 35
  • 98.55 (n)
  • 98.55 (a)
MRPL54 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL54 35
  • 80.43 (n)
  • 74.64 (a)
MRPL54 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL54 35
  • 81.64 (n)
  • 78.26 (a)
MRPL54 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl54 35
  • 75.56 (n)
  • 70.37 (a)
Mrpl54 16
Mrpl54 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL54 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL54 36
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl54 35
  • 76.05 (n)
  • 71.11 (a)
chicken
(Gallus gallus)
Aves MRPL54 35
  • 66.99 (n)
  • 60.58 (a)
MRPL54 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL54 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl54 35
  • 63.42 (n)
  • 63.72 (a)
zebrafish
(Danio rerio)
Actinopterygii mrpl54 35
  • 63.14 (n)
  • 62.5 (a)
mrpl54 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mRpL54 36
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3539 36
  • 29 (a)
OneToOne
Species with no ortholog for MRPL54:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL54 Gene

ENSEMBL:
Gene Tree for MRPL54 (if available)
TreeFam:
Gene Tree for MRPL54 (if available)

Paralogs for MRPL54 Gene

Pseudogenes.org Pseudogenes for MRPL54 Gene

genes like me logo Genes that share paralogs with MRPL54: view

No data available for Paralogs for MRPL54 Gene

Variants for MRPL54 Gene

Sequence variations from dbSNP and Humsavar for MRPL54 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7239 -- 3,767,267(-) ATCTC(A/G)AACAG reference, synonymous-codon
rs1047962 -- 3,767,362(+) GCGCC(A/C)CAACC reference, missense
rs2368924 -- 3,766,223(-) gcggg(A/C)acctg intron-variant
rs2368925 -- 3,765,914(-) AAAAA(A/T)TTTTT intron-variant
rs3177620 -- 3,767,552(+) GCTTT(C/T)TGGGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPL54 Gene

Variant ID Type Subtype PubMed ID
nsv910722 CNV Loss 21882294
dgv3651n71 CNV Loss 21882294
nsv470114 CNV Loss 18288195
dgv3660n71 CNV Loss 21882294
dgv3662n71 CNV Loss 21882294
nsv509718 CNV Insertion 20534489
nsv910768 CNV Loss 21882294
nsv910770 CNV Loss 21882294
dgv3663n71 CNV Loss 21882294
nsv910775 CNV Loss 21882294
nsv910777 CNV Loss 21882294

Relevant External Links for MRPL54 Gene

HapMap Linkage Disequilibrium report
MRPL54

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL54 Gene

Disorders for MRPL54 Gene

Relevant External Links for MRPL54

Genetic Association Database (GAD)
MRPL54
Human Genome Epidemiology (HuGE) Navigator
MRPL54
genes like me logo Genes that share disorders with MRPL54: view

No data available for UniProtKB/Swiss-Prot for MRPL54 Gene

Publications for MRPL54 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. (PMID: 12706105) Zhang Z. … Gerstein M. (Genomics 2003) 3

Products for MRPL54 Gene

Sources for MRPL54 Gene

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