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Aliases for MRPL54 Gene

Aliases for MRPL54 Gene

  • Mitochondrial Ribosomal Protein L54 2 3 5
  • MRP-L54 3 4
  • L54mt 3 4

External Ids for MRPL54 Gene

Previous GeneCards Identifiers for MRPL54 Gene

  • GC19U990297
  • GC19P003702
  • GC19P003713
  • GC19P003527

Summaries for MRPL54 Gene

Entrez Gene Summary for MRPL54 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL54 Gene

MRPL54 (Mitochondrial Ribosomal Protein L54) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include poly(A) RNA binding.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL54 Gene

Genomics for MRPL54 Gene

Regulatory Elements for MRPL54 Gene

Enhancers for MRPL54 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPL54 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL54 Gene

3,762,664 bp from pter
3,768,575 bp from pter
5,912 bases
Plus strand

Genomic View for MRPL54 Gene

Genes around MRPL54 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL54 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL54 Gene

Proteins for MRPL54 Gene

  • Protein details for MRPL54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L54, mitochondrial
    Protein Accession:

    Protein attributes for MRPL54 Gene

    138 amino acids
    Molecular mass:
    15819 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL54 Gene

neXtProt entry for MRPL54 Gene

Proteomics data for MRPL54 Gene at MOPED

Post-translational modifications for MRPL54 Gene

No Post-translational modifications

Other Protein References for MRPL54 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL54 Gene

Domains & Families for MRPL54 Gene

Gene Families for MRPL54 Gene

Protein Domains for MRPL54 Gene


Suggested Antigen Peptide Sequences for MRPL54 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPL54: view

No data available for UniProtKB/Swiss-Prot for MRPL54 Gene

Function for MRPL54 Gene

Phenotypes for MRPL54 Gene

genes like me logo Genes that share phenotypes with MRPL54: view

Animal Models for MRPL54 Gene

MGI Knock Outs for MRPL54:

Animal Model Products

miRNA for MRPL54 Gene

miRTarBase miRNAs that target MRPL54

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRPL54 Gene

Localization for MRPL54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL54 Gene


Subcellular locations from

Jensen Localization Image for MRPL54 Gene COMPARTMENTS Subcellular localization image for MRPL54 gene
Compartment Confidence
mitochondrion 5
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPL54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPL54: view

Pathways & Interactions for MRPL54 Gene

genes like me logo Genes that share pathways with MRPL54: view

Gene Ontology (GO) - Biological Process for MRPL54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL54: view

No data available for SIGNOR curated interactions for MRPL54 Gene

Drugs & Compounds for MRPL54 Gene

No Compound Related Data Available

Transcripts for MRPL54 Gene

mRNA/cDNA for MRPL54 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(126) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRPL54 Gene

Mitochondrial ribosomal protein L54:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL54 Gene

No ASD Table

Relevant External Links for MRPL54 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL54 Gene

mRNA expression in normal human tissues for MRPL54 Gene

Protein differential expression in normal tissues from HIPED for MRPL54 Gene

This gene is overexpressed in Bone (12.9), Lung (11.3), Breast (9.9), and Pancreas (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL54 Gene

SOURCE GeneReport for Unigene cluster for MRPL54 Gene Hs.356578

genes like me logo Genes that share expression patterns with MRPL54: view

Protein tissue co-expression partners for MRPL54 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL54 Gene

Orthologs for MRPL54 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL54 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPL54 35
  • 80.43 (n)
  • 74.64 (a)
MRPL54 36
  • 75 (a)
(Canis familiaris)
Mammalia MRPL54 35
  • 81.64 (n)
  • 78.26 (a)
MRPL54 36
  • 78 (a)
(Mus musculus)
Mammalia Mrpl54 35
  • 75.56 (n)
  • 70.37 (a)
Mrpl54 16
Mrpl54 36
  • 70 (a)
(Pan troglodytes)
Mammalia MRPL54 35
  • 98.55 (n)
  • 98.55 (a)
MRPL54 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mrpl54 35
  • 76.05 (n)
  • 71.11 (a)
(Monodelphis domestica)
Mammalia MRPL54 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL54 36
  • 51 (a)
(Gallus gallus)
Aves MRPL54 35
  • 66.99 (n)
  • 60.58 (a)
MRPL54 36
  • 55 (a)
(Anolis carolinensis)
Reptilia MRPL54 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl54 35
  • 63.42 (n)
  • 63.72 (a)
(Danio rerio)
Actinopterygii mrpl54 35
  • 63.14 (n)
  • 62.5 (a)
mrpl54 36
  • 48 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL54 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3539 36
  • 29 (a)
Species with no ortholog for MRPL54:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL54 Gene

Gene Tree for MRPL54 (if available)
Gene Tree for MRPL54 (if available)

Paralogs for MRPL54 Gene Pseudogenes for MRPL54 Gene

genes like me logo Genes that share paralogs with MRPL54: view

No data available for Paralogs for MRPL54 Gene

Variants for MRPL54 Gene

Sequence variations from dbSNP and Humsavar for MRPL54 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs7259446 -- 3,765,582(+) gcttT(A/T)TCTTA intron-variant
rs1047962 -- 3,767,362(+) GCGCC(A/C/G)CAACC reference, missense
rs140430522 -- 3,765,209(+) AGCGA(A/G)GCCCT reference, synonymous-codon
rs140566768 -- 3,765,695(+) GAGTT(C/T)GAGAC intron-variant
rs140779470 -- 3,767,741(+) GCCCC(A/G)GCCCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MRPL54 Gene

Variant ID Type Subtype PubMed ID
nsv910722 CNV Loss 21882294
dgv3651n71 CNV Loss 21882294
nsv470114 CNV Loss 18288195
dgv3660n71 CNV Loss 21882294
dgv3662n71 CNV Loss 21882294
nsv509718 CNV Insertion 20534489
nsv910768 CNV Loss 21882294
nsv910770 CNV Loss 21882294
dgv3663n71 CNV Loss 21882294
nsv910775 CNV Loss 21882294
nsv910777 CNV Loss 21882294

Variation tolerance for MRPL54 Gene

Residual Variation Intolerance Score: 68.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MRPL54 Gene

Disorders for MRPL54 Gene

Relevant External Links for MRPL54

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPL54 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL54 Gene

Publications for MRPL54 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PMID: 23402259) Chen R. … Zhang N. (J. Proteome Res. 2013) 3

Products for MRPL54 Gene

Sources for MRPL54 Gene