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Aliases for MRPL53 Gene

Aliases for MRPL53 Gene

  • Mitochondrial Ribosomal Protein L53 2 3
  • L53MT 3 4
  • 39S Ribosomal Protein L53, Mitochondrial 3
  • MRP-L53 4

External Ids for MRPL53 Gene

Summaries for MRPL53 Gene

Entrez Gene Summary for MRPL53 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 1p. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL53 Gene

MRPL53 (Mitochondrial Ribosomal Protein L53) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL53 Gene

Genomics for MRPL53 Gene

Genomic Location for MRPL53 Gene

74,471,958 bp from pter
74,473,322 bp from pter
1,365 bases
Minus strand

Genomic View for MRPL53 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL53 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL53 Gene

Regulatory Elements for MRPL53 Gene

Proteins for MRPL53 Gene

  • Protein details for MRPL53 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L53, mitochondrial
    Protein Accession:
    Secondary Accessions:

    Protein attributes for MRPL53 Gene

    112 amino acids
    Molecular mass:
    12107 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL53 Gene

neXtProt entry for MRPL53 Gene

Proteomics data for MRPL53 Gene at MOPED

Post-translational modifications for MRPL53 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL53 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL53 Gene

Domains for MRPL53 Gene

Gene Families for MRPL53 Gene

  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL53 Gene

genes like me logo Genes that share domains with MRPL53: view

No data available for UniProtKB/Swiss-Prot for MRPL53 Gene

Function for MRPL53 Gene

Gene Ontology (GO) - Molecular Function for MRPL53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with MRPL53: view

miRNA for MRPL53 Gene

miRTarBase miRNAs that target MRPL53

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL53 Gene

Localization for MRPL53 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL53 Gene


Subcellular locations from

Jensen Localization Image for MRPL53 Gene COMPARTMENTS Subcellular localization image for MRPL53 gene
Compartment Confidence
mitochondrion 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRPL53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL53: view

Pathways for MRPL53 Gene

SuperPathways for MRPL53 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRPL53 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL53: view

No data available for Pathways by source for MRPL53 Gene

Transcripts for MRPL53 Gene

mRNA/cDNA for MRPL53 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(153) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRPL53 Gene

Mitochondrial ribosomal protein L53:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL53 Gene

No ASD Table

Relevant External Links for MRPL53 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL53 Gene

mRNA expression in normal human tissues for MRPL53 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL53 Gene

SOURCE GeneReport for Unigene cluster for MRPL53 Gene Hs.534527

genes like me logo Genes that share expressions with MRPL53: view

Orthologs for MRPL53 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPL53 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 37
  • 98 (a)
MRPL53 36
  • 99.4 (n)
  • 99.11 (a)
MRPL53 37
  • 99 (a)
(Bos Taurus)
Mammalia MRPL53 36
  • 88.1 (n)
  • 91.96 (a)
MRPL53 37
  • 92 (a)
(Canis familiaris)
Mammalia MRPL53 36
  • 87.2 (n)
  • 91.96 (a)
(Mus musculus)
Mammalia Mrpl53 36
  • 82.41 (n)
  • 87.96 (a)
Mrpl53 16
Mrpl53 37
  • 83 (a)
(Rattus norvegicus)
Mammalia Mrpl53 36
  • 79.51 (n)
  • 86.24 (a)
(Gallus gallus)
Aves MRPL53 36
  • 56.94 (n)
  • 60.42 (a)
MRPL53 37
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl53 36
  • 51.69 (n)
  • 50.56 (a)
(Danio rerio)
Actinopterygii MRPL53 (1 of 2) 37
  • 49 (a)
MRPL53 (2 of 2) 37
  • 49 (a)
zgc:103761 36
  • 54.81 (n)
  • 52.88 (a)
Species with no ortholog for MRPL53:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MRPL53 Gene

Gene Tree for MRPL53 (if available)
Gene Tree for MRPL53 (if available)

Paralogs for MRPL53 Gene Pseudogenes for MRPL53 Gene

genes like me logo Genes that share paralogs with MRPL53: view

No data available for Paralogs for MRPL53 Gene

Variants for MRPL53 Gene

Sequence variations from dbSNP and Humsavar for MRPL53 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs10204697 -- 74,471,976(+) TTCCA(A/G)AAACA utr-variant-3-prime
rs11554617 -- 74,472,159(-) CGCGG(C/T)GGGCA reference, missense
rs12615070 -- 74,471,558(+) tgggc(A/C)cagta downstream-variant-500B
rs12621618 -- 74,471,547(+) AGTAA(A/G)AGggc downstream-variant-500B
rs75814234 -- 74,471,461(+) TGACT(C/T)GGCCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MRPL53 Gene

Variant ID Type Subtype PubMed ID
dgv1199e1 CNV Complex 17122850
nsv458185 CNV Loss 19166990
nsv515851 CNV Loss 19592680
dgv4166n71 CNV Loss 21882294

Relevant External Links for MRPL53 Gene

HapMap Linkage Disequilibrium report

Disorders for MRPL53 Gene

No disorders were found for MRPL53 Gene.

No data available for UniProtKB/Swiss-Prot for MRPL53 Gene

Publications for MRPL53 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. (PMID: 12706105) Zhang Z. … Gerstein M. (Genomics 2003) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for MRPL53 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MRPL53
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL53
    • Block miRNA regulation of MRPL53 using miScript Target Protectors

    Sources for MRPL53 Gene

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