MRPL53 Gene
protein-coding GIFtS: 40
GCID: GC02M074701
|
|
mitochondrial ribosomal protein L53
| |
Aliases
for MRPL53 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein L531 2 | | 39S Ribosomal Protein L53, Mitochondrial2 | | L53MT2 | | L53mt3 | | MRP-L533 |
Export aliases for MRPL53 gene to outside databasesPrevious GC identifers: GC02M074836 GC02M074911 GC02M074657 GC02M074673 GC02M074611 GC02M074552 GC02M074435 |
Summaries
for MRPL53 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPL53:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.A pseudogene corresponding to this gene is found on chromosome 1p. (provided by RefSeq, Jul 2008)
|
Genomic Views
for MRPL53 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPL53 gene promoter:
ER-alpha Elk-1 NF-1 NF-1/L GCNF Olf-1 MyoD GCNF-1 Meis-1a GCNF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPL53
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL53 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p13.1 Ensembl cytogenetic band: 2p13.1 HGNC cytogenetic band: 2p13.1MRPL53 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M074701: view genomic region
(about GC identifiers)
Start:
|
74,699,085 bp from pter |
End:
|
74,700,449 bp from pter |
Size:
|
1,365 bases |
Orientation:
|
minus strand |
|
Proteins
for MRPL53 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RM53_HUMAN, Q96EL3 (See
protein sequence)Recommended Name: 39S ribosomal protein L53, mitochondrial precursor Size: 112 amino acids; 12107 Da
Subcellular location: Mitochondrion (By similarity)Explore the universe of human proteins at neXtProt for MRPL53: NX_Q96EL3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96EL3
MRPL53 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_444278.1
ENSEMBL proteins: ENSP00000258105 ENSP00000386920
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MRPL53 for ontologies About GeneDecksing
MRPL53 Antibody Products:
Assay Products for MRPL53: |
Protein
Domains /
Families
for MRPL53 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPL53 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96EL3ProtoNet protein and cluster: Q96EL3 |
Function
for MRPL53 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL53 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL53
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRPL53 (NM_053050) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL53 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL53 |
|
Pathways & Interactions
for MRPL53 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL53
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for MRPL53 (Q96EL33 ENSP000002581054) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for MRPL53 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPL53
Search CenterWatch for drugs/clinical trials and news about MRPL53 / RM53
|
Transcripts
for MRPL53 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPL53 gene: NM_053050.4 Unigene Cluster for MRPL53: Mitochondrial ribosomal protein L53 Hs.534527 [show with all ESTs]Unigene Representative Sequence: BM4674624 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000258105(uc002sln.3) ENST00000409710 ENST00000467349 ENST00000468875
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL53 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL53
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRPL53 (NM_053050) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL53 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL53 |
Additional cDNA sequence: BC012163.1 7 DOTS entries: DT.97778002 DT.315678 DT.95166006 DT.120931179 DT.97806978 DT.97842868 DT.97842869 24/153 AceView cDNA sequences (see all 153): AW157651 BQ016433 AI493696 BU075817 AA424037 BQ212301 CK904548 BG475270 BM903971 AK075209 BQ014848 BM695872 BG482977 BM707017 BM054850 BC012163 AI564950 AI340186 BI858166 NM_053050 AW081076 AI928898 AW004617 BF941879
GeneLoc Exon Structure
|
Expression
for MRPL53 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPL53 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACGGCTCCGA
About this image
See MRPL53 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPL53
SOURCE GeneReport for Unigene cluster: Hs.534527
SABiosciences Custom PCR Arrays for MRPL53
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL53
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL53 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL53 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL53 |
Orthologs
for MRPL53 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for MRPL53 gene from 3/7 species (see all 7) About this table
ENSEMBL Gene Tree for MRPL53 (if available)
TreeFam Gene Tree for MRPL53 (if available) |
Paralogs
for MRPL53 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRPL53 gene
MRPL53 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MRPL53
PGOHUM00000244146
|
Genomic Variants
for MRPL53 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPL53 (74699085 - 74700449 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for MRPL53
3 CNVs: 50556 3366 50558 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for MRPL53 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRPL53 for disorders About MalaCards
MRPL53 for disorders About GeneDecksing
OMIM gene information: 611857
OMIM disorders: --
Export disorders for MRPL53 gene to outside databases
|
Publications
for MRPL53 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPL53 gene integrated from 9 sources:
(articles sorted by number of sources associating them with MRPL53) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PubMed id 11551941)1, 3 Koc E.C....Spremulli L.L. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. (PubMed id 12706105)1 Zhang Z. and Gerstein M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (2001)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for MRPL53 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPL53 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPL53 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPL53 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPL53 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRPL53 gene:
Search GeneIP for patents involving MRPL53
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPL53 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRPL53 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPL53 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL53 | | | OriGene Protein Over-expression Lysate for MRPL53 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRPL53 | | OriGene 3'-UTR Clone for MRPL53 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL53 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL53 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for MRPL53 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MRPL53 | | OriGene Custom Protein Services for MRPL53 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPL53 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL53 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL53 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPL53 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL53 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL53 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for MRPL53 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | MRPL53 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for MRPL53 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL53 |
|
|
|
|
