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Aliases for MRPL51 Gene

Aliases for MRPL51 Gene

  • Mitochondrial Ribosomal Protein L51 2 3
  • MRP64 3 4 6
  • Mitochondrial Ribosomal Protein 64 2 3
  • MRP-L51 3 4
  • BMRP-64 3 4
  • BMRP64 3 4
  • L51mt 3 4
  • 39S Ribosomal Protein L51, Mitochondrial 3
  • Mitochondrial Ribosomal Protein BMRP64 3
  • HSPC241 3
  • CDA09 3

External Ids for MRPL51 Gene

Previous Symbols for MRPL51 Gene

  • MRP64

Summaries for MRPL51 Gene

Entrez Gene Summary for MRPL51 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 4p and 21q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL51 Gene

MRPL51 (Mitochondrial Ribosomal Protein L51) is a Protein Coding gene. GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL51 Gene

Genomics for MRPL51 Gene

Genomic Location for MRPL51 Gene

Start:
6,491,886 bp from pter
End:
6,493,841 bp from pter
Size:
1,956 bases
Orientation:
Minus strand

Genomic View for MRPL51 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL51 Gene

Regulatory Elements for MRPL51 Gene

Proteins for MRPL51 Gene

  • Protein details for MRPL51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4U2R6-RM51_HUMAN
    Recommended name:
    39S ribosomal protein L51, mitochondrial
    Protein Accession:
    Q4U2R6
    Secondary Accessions:
    • Q96Q57
    • Q9BQ36
    • Q9P0N7

    Protein attributes for MRPL51 Gene

    Size:
    128 amino acids
    Molecular mass:
    15095 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with OXA1L (By similarity).

    Three dimensional structures from OCA and Proteopedia for MRPL51 Gene

neXtProt entry for MRPL51 Gene

Proteomics data for MRPL51 Gene at MOPED

Post-translational modifications for MRPL51 Gene

No Post-translational modifications

Other Protein References for MRPL51 Gene

No data available for DME Specific Peptides for MRPL51 Gene

Domains for MRPL51 Gene

Gene Families for MRPL51 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL51 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with MRPL51: view

No data available for UniProtKB/Swiss-Prot for MRPL51 Gene

Function for MRPL51 Gene

Gene Ontology (GO) - Molecular Function for MRPL51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome ISS --
GO:0005515 protein binding IPI 20601428
genes like me logo Genes that share ontologies with MRPL51: view

Phenotypes for MRPL51 Gene

GenomeRNAi human phenotypes for MRPL51:
genes like me logo Genes that share phenotypes with MRPL51: view

miRNA for MRPL51 Gene

miRTarBase miRNAs that target MRPL51

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL51 Gene

Localization for MRPL51 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL51 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL51 Gene COMPARTMENTS Subcellular localization image for MRPL51 gene
Compartment Confidence
mitochondrion 4
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MRPL51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome IDA 20601428
GO:0005762 mitochondrial large ribosomal subunit ISS --
genes like me logo Genes that share ontologies with MRPL51: view

Pathways for MRPL51 Gene

SuperPathways for MRPL51 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRPL51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation ISS --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
genes like me logo Genes that share ontologies with MRPL51: view

No data available for Pathways by source for MRPL51 Gene

Transcripts for MRPL51 Gene

Unigene Clusters for MRPL51 Gene

Mitochondrial ribosomal protein L51:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL51 Gene

No ASD Table

Relevant External Links for MRPL51 Gene

GeneLoc Exon Structure for
MRPL51
ECgene alternative splicing isoforms for
MRPL51

Expression for MRPL51 Gene

mRNA expression in normal human tissues for MRPL51 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL51 Gene

SOURCE GeneReport for Unigene cluster for MRPL51 Gene Hs.55847

genes like me logo Genes that share expressions with MRPL51: view

Orthologs for MRPL51 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL51 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL51 36
  • 99.74 (n)
  • 99.22 (a)
MRPL51 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL51 36
  • 84.37 (n)
  • 82.03 (a)
MRPL51 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL51 36
  • 85.42 (n)
  • 80.47 (a)
MRPL51 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl51 36
  • 80.73 (n)
  • 82.03 (a)
Mrpl51 16
Mrpl51 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL51 37
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL51 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl51 36
  • 79.69 (n)
  • 78.12 (a)
chicken
(Gallus gallus)
Aves MRPL51 36
  • 61.48 (n)
  • 63.93 (a)
MRPL51 37
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL51 37
  • 54 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24363 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl51 36
  • 63.27 (n)
  • 68.52 (a)
Str.10969 36
zebrafish
(Danio rerio)
Actinopterygii MRPL51 37
  • 55 (a)
OneToOne
zgc:110255 36
  • 57.97 (n)
  • 60.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL51 37
  • 25 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrpl-51 37
  • 19 (a)
OneToOne
Species with no ortholog for MRPL51:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL51 Gene

ENSEMBL:
Gene Tree for MRPL51 (if available)
TreeFam:
Gene Tree for MRPL51 (if available)

Paralogs for MRPL51 Gene

Pseudogenes.org Pseudogenes for MRPL51 Gene

genes like me logo Genes that share paralogs with MRPL51: view

No data available for Paralogs for MRPL51 Gene

Variants for MRPL51 Gene

Sequence variations from dbSNP and Humsavar for MRPL51 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1048402 -- 6,492,009(-) CTAAT(G/T)CCTTT downstream-variant-500B
rs2109428 -- 6,492,061(+) CCTAA(A/G)ATCCT downstream-variant-500B
rs2109429 -- 6,492,069(+) CCTAA(A/G)ATCTA downstream-variant-500B
rs2159529 -- 6,491,936(+) CTTTA(A/G)AAACA downstream-variant-500B
rs3948654 -- 6,492,121(+) ATCTA(A/G)AGGAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MRPL51 Gene

Variant ID Type Subtype PubMed ID
esv34325 CNV Gain 17911159
dgv453e1 CNV Complex 17122850
esv34390 CNV Gain 17911159
essv12131 CNV CNV 17122850
nsv525022 CNV Gain 19592680

Relevant External Links for MRPL51 Gene

HapMap Linkage Disequilibrium report
MRPL51

Disorders for MRPL51 Gene

Relevant External Links for MRPL51

Genetic Association Database (GAD)
MRPL51
Human Genome Epidemiology (HuGE) Navigator
MRPL51
genes like me logo Genes that share disorders with MRPL51: view

No data available for UniProtKB/Swiss-Prot for MRPL51 Gene

Publications for MRPL51 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3 4
  2. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PMID: 11402041) Suzuki T. … Watanabe K. (J. Biol. Chem. 2001) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MRPL51 Gene

  • antibodies-online proteins for MRPL51
  • antibodies-online antibodies for MRPL51
  • antibodies-online kits for MRPL51

Sources for MRPL51 Gene

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