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Aliases for MRPL51 Gene

Aliases for MRPL51 Gene

  • Mitochondrial Ribosomal Protein L51 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein ML51 3 4
  • Mitochondrial Ribosomal Protein 64 2 3
  • MRP-L51 3 4
  • BMRP-64 3 4
  • BMRP64 3 4
  • MRP64 3 4
  • L51mt 3 4
  • 39S Ribosomal Protein L51, Mitochondrial 3
  • Mitochondrial Ribosomal Protein BMRP64 3
  • HSPC241 3
  • CDA09 3

External Ids for MRPL51 Gene

Previous HGNC Symbols for MRPL51 Gene

  • MRP64

Previous GeneCards Identifiers for MRPL51 Gene

  • GC12M006455
  • GC12M006575
  • GC12M006601

Summaries for MRPL51 Gene

Entrez Gene Summary for MRPL51 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 4p and 21q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL51 Gene

MRPL51 (Mitochondrial Ribosomal Protein L51) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance. GO annotations related to this gene include structural constituent of ribosome.

Additional gene information for MRPL51 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL51 Gene

Genomics for MRPL51 Gene

Regulatory Elements for MRPL51 Gene

Enhancers for MRPL51 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H006459 1.4 Ensembl ENCODE dbSUPER 41.7 +31.7 31698 6 HDGF PKNOX1 ZFP64 BMI1 ZNF143 ZNF207 ATF7 ETV6 RUNX3 CREM ZNF384 ENSG00000219410 CHD4 ENSG00000247853 TAPBPL MRPL51 VAMP1 P3H3 NOP2 SCARNA12
GH12H006492 1.1 ENCODE 48.2 -0.3 -297 3 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF207 MRPL51 TAPBPL CHD4 NOP2 ENSG00000247853 ZNF384 ENSG00000219410 VAMP1 ENSG00000255966 GAPDH
GH12H006449 1.2 ENCODE dbSUPER 41.3 +41.8 41784 4 PKNOX1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF207 YY2 TAPBPL MRPL51 CD27-AS1 PTPN6 VAMP1 ENSG00000276718
GH12H006530 1.4 ENCODE dbSUPER 28.8 -43.3 -43255 12 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A ZNF384 CHD4 ENSG00000219410 NCAPD2 ENSG00000247853 NOP2 SPSB2 MRPL51 ENSG00000256967 ING4
GH12H006529 0.6 dbSUPER 38.2 -35.9 -35878 0 ZNF316 POLR2A GLIS1 EMSY ZIC2 MAFK ZKSCAN1 MRPL51 TAPBPL NCAPD2 IFFO1 NOP2 CHD4 LPAR5 ACRBP PIR34682 ENSG00000255966
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPL51 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL51 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000048314 41 2401 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143

Genomic Location for MRPL51 Gene

Chromosome:
12
Start:
6,491,886 bp from pter
End:
6,493,841 bp from pter
Size:
1,956 bases
Orientation:
Minus strand

Genomic View for MRPL51 Gene

Genes around MRPL51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL51 Gene

Proteins for MRPL51 Gene

  • Protein details for MRPL51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4U2R6-RM51_HUMAN
    Recommended name:
    39S ribosomal protein L51, mitochondrial
    Protein Accession:
    Q4U2R6
    Secondary Accessions:
    • Q96Q57
    • Q9BQ36
    • Q9P0N7

    Protein attributes for MRPL51 Gene

    Size:
    128 amino acids
    Molecular mass:
    15095 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25278503, PubMed:25838379). Interacts with OXA1L (By similarity).

    Three dimensional structures from OCA and Proteopedia for MRPL51 Gene

neXtProt entry for MRPL51 Gene

Post-translational modifications for MRPL51 Gene

No Post-translational modifications

Other Protein References for MRPL51 Gene

No data available for DME Specific Peptides for MRPL51 Gene

Domains & Families for MRPL51 Gene

Gene Families for MRPL51 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for MRPL51 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL51 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4U2R6

UniProtKB/Swiss-Prot:

RM51_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mL51 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mL51 family.
genes like me logo Genes that share domains with MRPL51: view

Function for MRPL51 Gene

Phenotypes From GWAS Catalog for MRPL51 Gene

Gene Ontology (GO) - Molecular Function for MRPL51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome ISS 11402041
GO:0005515 protein binding IPI 20601428
genes like me logo Genes that share ontologies with MRPL51: view
genes like me logo Genes that share phenotypes with MRPL51: view

Animal Models for MRPL51 Gene

MGI Knock Outs for MRPL51:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MRPL51
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRPL51 Gene

Localization for MRPL51 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL51 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL51 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPL51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome IDA,IEA 20601428
GO:0005762 mitochondrial large ribosomal subunit ISS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL51: view

Pathways & Interactions for MRPL51 Gene

genes like me logo Genes that share pathways with MRPL51: view

Gene Ontology (GO) - Biological Process for MRPL51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,ISS --
GO:0032543 mitochondrial translation ISS 11402041
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL51: view

No data available for SIGNOR curated interactions for MRPL51 Gene

Drugs & Compounds for MRPL51 Gene

No Compound Related Data Available

Transcripts for MRPL51 Gene

Unigene Clusters for MRPL51 Gene

Mitochondrial ribosomal protein L51:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MRPL51
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL51 Gene

No ASD Table

Relevant External Links for MRPL51 Gene

GeneLoc Exon Structure for
MRPL51
ECgene alternative splicing isoforms for
MRPL51

Expression for MRPL51 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL51 Gene

Protein differential expression in normal tissues from HIPED for MRPL51 Gene

This gene is overexpressed in Breast (25.9), Pancreas (21.6), Lung (8.1), and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL51 Gene



NURSA nuclear receptor signaling pathways regulating expression of MRPL51 Gene:

MRPL51

SOURCE GeneReport for Unigene cluster for MRPL51 Gene:

Hs.55847

Evidence on tissue expression from TISSUES for MRPL51 Gene

  • Blood(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with MRPL51: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL51 Gene

Orthologs for MRPL51 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL51 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL51 33 34
  • 99.74 (n)
dog
(Canis familiaris)
Mammalia MRPL51 33 34
  • 85.42 (n)
cow
(Bos Taurus)
Mammalia MRPL51 33 34
  • 84.37 (n)
mouse
(Mus musculus)
Mammalia Mrpl51 33 16 34
  • 80.73 (n)
rat
(Rattus norvegicus)
Mammalia Mrpl51 33
  • 79.69 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPL51 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL51 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL51 33 34
  • 61.48 (n)
lizard
(Anolis carolinensis)
Reptilia MRPL51 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl51 33
  • 63.27 (n)
Str.10969 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24363 33
zebrafish
(Danio rerio)
Actinopterygii zgc:110255 33
  • 57.97 (n)
MRPL51 34
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mRpL51 34
  • 25 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrpl-51 34
  • 19 (a)
OneToOne
Species where no ortholog for MRPL51 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL51 Gene

ENSEMBL:
Gene Tree for MRPL51 (if available)
TreeFam:
Gene Tree for MRPL51 (if available)

Paralogs for MRPL51 Gene

Pseudogenes.org Pseudogenes for MRPL51 Gene

genes like me logo Genes that share paralogs with MRPL51: view

No data available for Paralogs for MRPL51 Gene

Variants for MRPL51 Gene

Sequence variations from dbSNP and Humsavar for MRPL51 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1001125 -- 6,492,808(-) GCTGT(A/G)ACGAC intron-variant, upstream-variant-2KB
rs1001126 -- 6,492,736(-) AGCTG(C/T)TTACA intron-variant, upstream-variant-2KB
rs1001127 -- 6,492,577(-) AATGT(G/T)CCTTG intron-variant, upstream-variant-2KB
rs1001266777 -- 6,493,647(+) TGGAC(A/G)TCACT upstream-variant-2KB
rs1001297938 -- 6,493,411(+) GTCCG(C/T)GACTC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRPL51 Gene

Variant ID Type Subtype PubMed ID
esv2759876 CNV gain 17122850
esv34325 CNV gain 17911159
esv34390 CNV gain 17911159
nsv525022 CNV gain 19592680

Variation tolerance for MRPL51 Gene

Residual Variation Intolerance Score: 44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL51 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL51

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL51 Gene

Disorders for MRPL51 Gene

Relevant External Links for MRPL51

Genetic Association Database (GAD)
MRPL51
Human Genome Epidemiology (HuGE) Navigator
MRPL51
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL51

No disorders were found for MRPL51 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL51 Gene

Publications for MRPL51 Gene

  1. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc EC … Spremulli LL (The Journal of biological chemistry 2001) 2 3 4 60
  2. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N … Tanaka T (Genomics 2001) 2 3 4 60
  3. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 60
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for MRPL51 Gene

Sources for MRPL51 Gene

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