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Aliases for MRPL51 Gene

Aliases for MRPL51 Gene

  • Mitochondrial Ribosomal Protein L51 2 3 5
  • Mitochondrial Ribosomal Protein 64 2 3
  • MRP-L51 3 4
  • BMRP-64 3 4
  • BMRP64 3 4
  • MRP64 3 4
  • L51mt 3 4
  • Mitochondrial Ribosomal Protein BMRP64 3
  • HSPC241 3
  • CDA09 3

External Ids for MRPL51 Gene

Previous HGNC Symbols for MRPL51 Gene

  • MRP64

Previous GeneCards Identifiers for MRPL51 Gene

  • GC12M006455
  • GC12M006575
  • GC12M006601

Summaries for MRPL51 Gene

Entrez Gene Summary for MRPL51 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 4p and 21q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL51 Gene

MRPL51 (Mitochondrial Ribosomal Protein L51) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL51 Gene

Genomics for MRPL51 Gene

Regulatory Elements for MRPL51 Gene

Promoters for MRPL51 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL51 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL51 Gene

Chromosome:
12
Start:
6,491,886 bp from pter
End:
6,493,841 bp from pter
Size:
1,956 bases
Orientation:
Minus strand

Genomic View for MRPL51 Gene

Genes around MRPL51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL51 Gene

Proteins for MRPL51 Gene

  • Protein details for MRPL51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4U2R6-RM51_HUMAN
    Recommended name:
    39S ribosomal protein L51, mitochondrial
    Protein Accession:
    Q4U2R6
    Secondary Accessions:
    • Q96Q57
    • Q9BQ36
    • Q9P0N7

    Protein attributes for MRPL51 Gene

    Size:
    128 amino acids
    Molecular mass:
    15095 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with OXA1L (By similarity).

    Three dimensional structures from OCA and Proteopedia for MRPL51 Gene

neXtProt entry for MRPL51 Gene

Proteomics data for MRPL51 Gene at MOPED

Post-translational modifications for MRPL51 Gene

No Post-translational modifications

Other Protein References for MRPL51 Gene

Antibody Products

No data available for DME Specific Peptides for MRPL51 Gene

Domains & Families for MRPL51 Gene

Gene Families for MRPL51 Gene

Protein Domains for MRPL51 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL51 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPL51: view

No data available for UniProtKB/Swiss-Prot for MRPL51 Gene

Function for MRPL51 Gene

Phenotypes for MRPL51 Gene

genes like me logo Genes that share phenotypes with MRPL51: view

Animal Models for MRPL51 Gene

MGI Knock Outs for MRPL51:

Animal Model Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRPL51 Gene

Localization for MRPL51 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL51 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL51 Gene COMPARTMENTS Subcellular localization image for MRPL51 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for MRPL51 Gene

Pathways & Interactions for MRPL51 Gene

genes like me logo Genes that share pathways with MRPL51: view

Gene Ontology (GO) - Biological Process for MRPL51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation IEA,ISS --
GO:0032543 mitochondrial translation ISS,TAS 11402041
genes like me logo Genes that share ontologies with MRPL51: view

No data available for SIGNOR curated interactions for MRPL51 Gene

Drugs & Compounds for MRPL51 Gene

No Compound Related Data Available

Transcripts for MRPL51 Gene

Unigene Clusters for MRPL51 Gene

Mitochondrial ribosomal protein L51:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL51 Gene

No ASD Table

Relevant External Links for MRPL51 Gene

GeneLoc Exon Structure for
MRPL51
ECgene alternative splicing isoforms for
MRPL51

Expression for MRPL51 Gene

mRNA expression in normal human tissues for MRPL51 Gene

Protein differential expression in normal tissues from HIPED for MRPL51 Gene

This gene is overexpressed in Breast (25.9), Pancreas (21.6), Lung (8.1), and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL51 Gene



SOURCE GeneReport for Unigene cluster for MRPL51 Gene Hs.55847

genes like me logo Genes that share expression patterns with MRPL51: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MRPL51 Gene

Orthologs for MRPL51 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL51 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPL51 35
  • 84.37 (n)
  • 82.03 (a)
MRPL51 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL51 35
  • 85.42 (n)
  • 80.47 (a)
MRPL51 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl51 35
  • 80.73 (n)
  • 82.03 (a)
Mrpl51 16
Mrpl51 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPL51 35
  • 99.74 (n)
  • 99.22 (a)
MRPL51 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl51 35
  • 79.69 (n)
  • 78.12 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPL51 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL51 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL51 35
  • 61.48 (n)
  • 63.93 (a)
MRPL51 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL51 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl51 35
  • 63.27 (n)
  • 68.52 (a)
Str.10969 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24363 35
zebrafish
(Danio rerio)
Actinopterygii zgc:110255 35
  • 57.97 (n)
  • 60.87 (a)
MRPL51 36
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mRpL51 36
  • 25 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrpl-51 36
  • 19 (a)
OneToOne
Species with no ortholog for MRPL51:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL51 Gene

ENSEMBL:
Gene Tree for MRPL51 (if available)
TreeFam:
Gene Tree for MRPL51 (if available)

Paralogs for MRPL51 Gene

Pseudogenes.org Pseudogenes for MRPL51 Gene

genes like me logo Genes that share paralogs with MRPL51: view

No data available for Paralogs for MRPL51 Gene

Variants for MRPL51 Gene

Sequence variations from dbSNP and Humsavar for MRPL51 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_030079 -
rs1048402 -- 6,492,009(-) CTAAT(G/T)CCTTT downstream-variant-500B
rs2159529 -- 6,491,936(+) CTTTA(A/G)AAACA downstream-variant-500B
rs2109428 -- 6,492,061(+) CCTAA(A/G)ATCCT downstream-variant-500B
rs2109429 -- 6,492,069(+) CCTAA(A/G)ATCTA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MRPL51 Gene

Variant ID Type Subtype PubMed ID
esv34325 CNV Gain 17911159
dgv453e1 CNV Complex 17122850
esv34390 CNV Gain 17911159
essv12131 CNV CNV 17122850
nsv525022 CNV Gain 19592680

Variation tolerance for MRPL51 Gene

Residual Variation Intolerance Score: 44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL51 Gene

HapMap Linkage Disequilibrium report
MRPL51

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL51 Gene

Disorders for MRPL51 Gene

Relevant External Links for MRPL51

Genetic Association Database (GAD)
MRPL51
Human Genome Epidemiology (HuGE) Navigator
MRPL51
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL51

No disorders were found for MRPL51 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL51 Gene

Publications for MRPL51 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N. … Tanaka T. (Genomics 2001) 2 3 4 67
  2. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3

Products for MRPL51 Gene

Sources for MRPL51 Gene

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