MRPL51 Gene
protein-coding GIFtS: 45
GCID: GC12M006575
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mitochondrial ribosomal protein L51(Previous name: mitochondrial ribosomal protein 64 )
(Previous symbol: MRP64)
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Aliases
for MRPL51 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein L511 2 | | MRP-L512 3 | | MRP641 2 3 5 | | BMRP-641 | | BMRP641 | | CDA091 | | HSPC2411 2 | | 39S Ribosomal Protein L51, Mitochondrial2 | | Mitochondrial Ribosomal Protein 641 2 | | Mitochondrial Ribosomal Protein BMRP642 | | L51mt2 3 | | |
Export aliases for MRPL51 gene to outside databasesPrevious GC identifers: GC12M006455 GC12M006471 |
Summaries
for MRPL51 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPL51:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.Pseudogenes corresponding to this gene are found on chromosomes 4p and 21q. (provided by RefSeq, Jul 2008)
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Genomic Views
for MRPL51 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009759.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPL51 gene promoter:
Elk-1 Pbx1a CBF-C GATA-1 CBF-B CBF-A IRF-7A CP1C CP1A CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPL51
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL51 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13.3-p13.1 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.3-p13.1MRPL51 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M006575: view genomic region
(about GC identifiers)
Start:
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6,601,150 bp from pter |
End:
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6,603,007 bp from pter |
Size:
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1,858 bases |
Orientation:
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minus strand |
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Proteins
for MRPL51 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RM51_HUMAN, Q4U2R6 (See
protein sequence)Recommended Name: 39S ribosomal protein L51, mitochondrial precursor Size: 128 amino acids; 15095 Da
Subunit: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinctproteins. Interacts with OXA1L (By similarity)
Subcellular location: Mitochondrion (By similarity)
Secondary accessions: Q96Q57 Q9BQ36 Q9P0N7Explore the universe of human proteins at neXtProt for MRPL51: NX_Q4U2R6
MRPL51 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057581.2
ENSEMBL proteins: ENSP00000229238
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
-- | -- | | GO:0005761 | mitochondrial ribosome |
IDA | -- | | GO:0005762 | mitochondrial large ribosomal subunit |
ISS | -- |
MRPL51 for ontologies About GeneDecksing
MRPL51 Antibody Products:
Assay Products for MRPL51: |
Protein
Domains /
Families
for MRPL51 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPL51 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q4U2R6ProtoNet protein and cluster: Q4U2R6 |
Function
for MRPL51 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL51 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL51
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRPL51 (NM_016497) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL51 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL51 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL51 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003735 | structural constituent of ribosome |
ISS | -- | | GO:0005515 | protein binding |
IPI | -- |
MRPL51 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MRPL51:
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Pathways & Interactions
for MRPL51 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL51
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/231 Interacting proteins for MRPL51 (Q4U2R62, 3 ENSP000002292384) via UniProtKB, MINT, STRING, and/or I2D (see all 231)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006412 | translation |
ISS | -- |
MRPL51 for ontologies About GeneDecksing
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Drugs & Compounds
for MRPL51 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPL51
Search CenterWatch for drugs/clinical trials and news about MRPL51 / RM51
|
Transcripts
for MRPL51 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPL51 gene: NM_016497.3 Unigene Cluster for MRPL51: Mitochondrial ribosomal protein L51 Hs.55847 [show with all ESTs]Unigene Representative Sequence: CD5163617 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000229238(uc001qom.2) ENST00000537701 ENST00000543164 ENST00000543703
ENST00000538814 ENST00000543959 ENST00000540949
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL51 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL51
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRPL51 (NM_016497) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL51 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL51 |
Additional cDNA sequence: AB049959.1 AF151075.1 AF212248.1 BC000191.1 BC014329.1 14 DOTS entries: DT.100704747 DT.454417 DT.121201202 DT.91714612 DT.95107685 DT.100788898 DT.121201139 DT.100788900 DT.121201125 DT.121201138 DT.121201162 DT.92443670 DT.121201156 DT.92443674 24/267 AceView cDNA sequences (see all 267): BU732977 AA463687 AI224529 BI335786 F19538 BC000191 AA887208 BM855363 BU854908 AI338226 CD512746 BQ002788 BM855438 AA468096 AI371742 AI243176 BX375358 AA471119 BF971945 AI076158 AI687745 BQ227579 AA720885 AA366125
GeneLoc Exon Structure
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Expression
for MRPL51 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPL51 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGAAGTTTCG
About this image
See MRPL51 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPL51
SOURCE GeneReport for Unigene cluster: Hs.55847
SABiosciences Custom PCR Arrays for MRPL51
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL51
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL51 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL51 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL51 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL51 |
Orthologs
for MRPL51 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for MRPL51 gene from 7/18 species (see all 18) About this table
ENSEMBL Gene Tree for MRPL51 (if available)
TreeFam Gene Tree for MRPL51 (if available) |
Paralogs
for MRPL51 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRPL51 gene
MRPL51 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for MRPL51
PGOHUM00000239088
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Genomic Variants
for MRPL51 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPL51 (6601150 - 6603007 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for MRPL51
4 CNVs: 3872 8706 2967 8705 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL51 |
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Disorders
/ Diseases
for MRPL51 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRPL51 for disorders About MalaCards
MRPL51 for disorders About GeneDecksing
OMIM gene information: 611855
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MRPL51 (1 document)
Export disorders for MRPL51 gene to outside databases
|
Publications
for MRPL51 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPL51 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with MRPL51) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2, 3 Kenmochi N....Tanaka T. (2001)
- The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PubMed id 11551941)1, 2, 3 Koc E.C....Spremulli L.L. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit. (PubMed id 11402041)1, 2 Suzuki T....Watanabe K. (2001)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Properties of the C-terminal tail of human mitochondr ial inner membrane protein Oxa1L and its interactions with mammalian mitochondr ial ribosomes. (PubMed id 20601428)1 Haque M.E....Spremulli L.L. (2010)
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External Searches for MRPL51 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MRPL51 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPL51 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPL51 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPL51 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MRPL51 gene:
Search GeneIP for patents involving MRPL51
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPL51 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRPL51 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPL51 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL51 | | | OriGene Protein Over-expression Lysate for MRPL51 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRPL51 | | OriGene 3'-UTR Clone for MRPL51 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL51 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL51 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPL51 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL51 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL51 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPL51 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL51 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL51 |
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| | | | Search Tocris compounds for MRPL51 |
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 | | | MRPL51 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL51 |
|  |  |  | | | | ThermoFisher Antibodies for MRPL51 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL51 |
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