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Aliases for MRPL51 Gene

Aliases for MRPL51 Gene

  • Mitochondrial Ribosomal Protein L51 2 3 5
  • Mitochondrial Large Ribosomal Subunit Protein ML51 3 4
  • Mitochondrial Ribosomal Protein 64 2 3
  • MRP-L51 3 4
  • BMRP-64 3 4
  • BMRP64 3 4
  • MRP64 3 4
  • L51mt 3 4
  • 39S Ribosomal Protein L51, Mitochondrial 3
  • Mitochondrial Ribosomal Protein BMRP64 3
  • HSPC241 3
  • CDA09 3

External Ids for MRPL51 Gene

Previous HGNC Symbols for MRPL51 Gene

  • MRP64

Previous GeneCards Identifiers for MRPL51 Gene

  • GC12M006455
  • GC12M006575
  • GC12M006601

Summaries for MRPL51 Gene

Entrez Gene Summary for MRPL51 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 4p and 21q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL51 Gene

MRPL51 (Mitochondrial Ribosomal Protein L51) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. Gene Ontology (GO) annotations related to this gene include structural constituent of ribosome.

Additional gene information for MRPL51 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL51 Gene

Genomics for MRPL51 Gene

GeneHancer (GH) Regulatory Elements for MRPL51 Gene

Promoters and enhancers for MRPL51 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I006492 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 598.3 -0.3 -296 3.5 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 MRPL51 NCAPD2 TAPBPL ZNF384 NOP2 CHD4 ENSG00000247853 ENSG00000219410 SCARNA12 ENSG00000256967
GH12I006449 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 41.3 +41.8 41784 4.4 PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF207 TAPBPL CD27-AS1 MRPL51 PTPN6 VAMP1 CD27 ENSG00000276718
GH12I006530 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 28.8 -43.3 -43255 12.8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 GAPDH ENSG00000269968 ZNF384 ENSG00000219410 CHD4 ENSG00000247853 NCAPD2 NOP2 SPSB2 ENSG00000256967
GH12I006459 Enhancer 1.3 Ensembl ENCODE dbSUPER 41.7 +31.7 31697 6.3 HDGF PKNOX1 ZFP64 BMI1 IRF4 ZNF213 ZNF207 ZNF143 ATF7 ETV6 ZNF384 ENSG00000219410 CHD4 ENSG00000247853 TAPBPL MRPL51 NOP2 SCARNA12 VAMP1 P3H3
GH12I006468 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 17.5 +23.6 23596 3.1 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 VAMP1 TAPBPL ZNF384 NCAPD2 ENSG00000219410 ENSG00000247853 NOP2 ING4 CHD4 MRPL51
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MRPL51 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MRPL51 gene promoter:

Genomic Locations for MRPL51 Gene

Genomic Locations for MRPL51 Gene
chr12:6,491,886-6,493,841
(GRCh38/hg38)
Size:
1,956 bases
Orientation:
Minus strand
chr12:6,601,150-6,603,007
(GRCh37/hg19)

Genomic View for MRPL51 Gene

Genes around MRPL51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL51 Gene

Proteins for MRPL51 Gene

  • Protein details for MRPL51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4U2R6-RM51_HUMAN
    Recommended name:
    39S ribosomal protein L51, mitochondrial
    Protein Accession:
    Q4U2R6
    Secondary Accessions:
    • Q96Q57
    • Q9BQ36
    • Q9P0N7

    Protein attributes for MRPL51 Gene

    Size:
    128 amino acids
    Molecular mass:
    15095 Da
    Quaternary structure:
    • Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins (PubMed:25278503, PubMed:25838379). Interacts with OXA1L (By similarity).

    Three dimensional structures from OCA and Proteopedia for MRPL51 Gene

neXtProt entry for MRPL51 Gene

Post-translational modifications for MRPL51 Gene

No Post-translational modifications

Other Protein References for MRPL51 Gene

No data available for DME Specific Peptides for MRPL51 Gene

Domains & Families for MRPL51 Gene

Gene Families for MRPL51 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Ribosomal proteins

Protein Domains for MRPL51 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for MRPL51 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q4U2R6

UniProtKB/Swiss-Prot:

RM51_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mL51 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mL51 family.
genes like me logo Genes that share domains with MRPL51: view

Function for MRPL51 Gene

Phenotypes From GWAS Catalog for MRPL51 Gene

Gene Ontology (GO) - Molecular Function for MRPL51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome ISS 11402041
GO:0005515 protein binding IPI 20601428
genes like me logo Genes that share ontologies with MRPL51: view
genes like me logo Genes that share phenotypes with MRPL51: view

Animal Models for MRPL51 Gene

MGI Knock Outs for MRPL51:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRPL51 Gene

Localization for MRPL51 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL51 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPL51 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MRPL51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome IEA,IDA 20601428
GO:0005762 mitochondrial large ribosomal subunit ISS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL51: view

Pathways & Interactions for MRPL51 Gene

genes like me logo Genes that share pathways with MRPL51: view

Gene Ontology (GO) - Biological Process for MRPL51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation ISS,IEA --
GO:0032543 mitochondrial translation ISS 11402041
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL51: view

No data available for SIGNOR curated interactions for MRPL51 Gene

Drugs & Compounds for MRPL51 Gene

No Compound Related Data Available

Transcripts for MRPL51 Gene

Unigene Clusters for MRPL51 Gene

Mitochondrial ribosomal protein L51:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL51 Gene

No ASD Table

Relevant External Links for MRPL51 Gene

GeneLoc Exon Structure for
MRPL51
ECgene alternative splicing isoforms for
MRPL51

Expression for MRPL51 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPL51 Gene

Protein differential expression in normal tissues from HIPED for MRPL51 Gene

This gene is overexpressed in Breast (25.9), Pancreas (21.6), Lung (8.1), and Heart (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL51 Gene



NURSA nuclear receptor signaling pathways regulating expression of MRPL51 Gene:

MRPL51

SOURCE GeneReport for Unigene cluster for MRPL51 Gene:

Hs.55847

Evidence on tissue expression from TISSUES for MRPL51 Gene

  • Blood(4.1)
  • Eye(4)
genes like me logo Genes that share expression patterns with MRPL51: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPL51 Gene

Orthologs for MRPL51 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL51 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL51 34 33
  • 99.74 (n)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL51 33 34
  • 85.42 (n)
cow
(Bos Taurus)
Mammalia MRPL51 33 34
  • 84.37 (n)
mouse
(Mus musculus)
Mammalia Mrpl51 33 16 34
  • 80.73 (n)
rat
(Rattus norvegicus)
Mammalia Mrpl51 33
  • 79.69 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPL51 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL51 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL51 33 34
  • 61.48 (n)
lizard
(Anolis carolinensis)
Reptilia MRPL51 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl51 33
  • 63.27 (n)
Str.10969 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.24363 33
zebrafish
(Danio rerio)
Actinopterygii zgc:110255 33
  • 57.97 (n)
MRPL51 34
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mRpL51 34
  • 25 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mrpl-51 34
  • 19 (a)
OneToOne
Species where no ortholog for MRPL51 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL51 Gene

ENSEMBL:
Gene Tree for MRPL51 (if available)
TreeFam:
Gene Tree for MRPL51 (if available)

Paralogs for MRPL51 Gene

Pseudogenes.org Pseudogenes for MRPL51 Gene

genes like me logo Genes that share paralogs with MRPL51: view

No data available for Paralogs for MRPL51 Gene

Variants for MRPL51 Gene

Sequence variations from dbSNP and Humsavar for MRPL51 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1001125 -- 6,492,808(-) T/C intron_variant
rs1001126 -- 6,492,736(-) A/G intron_variant
rs1001127 -- 6,492,577(-) A/C intron_variant
rs1001266777 -- 6,493,647(-) G/A upstream_transcript_variant
rs1001297938 -- 6,493,411(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL51 Gene

Variant ID Type Subtype PubMed ID
esv2759876 CNV gain 17122850
esv34325 CNV gain 17911159
esv34390 CNV gain 17911159
nsv525022 CNV gain 19592680

Variation tolerance for MRPL51 Gene

Residual Variation Intolerance Score: 44.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MRPL51 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPL51

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL51 Gene

Disorders for MRPL51 Gene

Additional Disease Information for MRPL51

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for MRPL51 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL51 Gene

Publications for MRPL51 Gene

  1. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PMID: 11543634) Kenmochi N … Tanaka T (Genomics 2001) 2 3 4 58
  2. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc EC … Spremulli LL (The Journal of biological chemistry 2001) 2 3 4 58
  3. Structure of the large ribosomal subunit from human mitochondria. (PMID: 25278503) Brown A … Ramakrishnan V (Science (New York, N.Y.) 2014) 3 4 58
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for MRPL51 Gene

Sources for MRPL51 Gene

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