MRPL50 Gene
protein-coding GIFtS: 41
GCID: GC09M104149
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mitochondrial ribosomal protein L50
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Aliases
for MRPL50 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein L501 2 | | MRP-L501 2 3 | | L50mt2 3 | | FLJ204931 | | 39S Ribosomal Protein L50, Mitochondrial2 | | Mitochondrial 39S Ribosomal Protein L502 |
Export aliases for MRPL50 gene to outside databasesPrevious GC identifers: GC09M094952 GC09M095895 GC09M097609 GC09M099532 GC09M101231 GC09M103189 GC09M073751 |
Summaries
for MRPL50 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPL50:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a putative 39S subunitprotein and belongs to the L47P ribosomal protein family. Pseudogenes corresponding to this gene are found onchromosomes 2p, 2q, 5p, and 10q. (provided by RefSeq, Jul 2008)
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Genomic Views
for MRPL50 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPL50 gene promoter:
POU3F1 POU6F1 (c2) CREB HEN1 CP2 POU2F1 deltaCREB POU2F1a FOXO1a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPL50
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL50 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q31.1 Ensembl cytogenetic band: 9q31.1 HGNC cytogenetic band: 9q31.1MRPL50 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M104149: view genomic region
(about GC identifiers)
Start:
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104,149,915 bp from pter |
End:
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104,160,919 bp from pter |
Size:
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11,005 bases |
Orientation:
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minus strand |
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Proteins
for MRPL50 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RM50_HUMAN, Q8N5N7 (See
protein sequence)Recommended Name: 39S ribosomal protein L50, mitochondrial Size: 158 amino acids; 18325 Da
Subcellular location: Mitochondrion (By similarity)
Secondary accessions: Q5T7E0 Q9NX15Explore the universe of human proteins at neXtProt for MRPL50: NX_Q8N5N7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N5N7
MRPL50 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_061924.1
ENSEMBL proteins: ENSP00000363999 ENSP00000443844
Human Recombinant Protein Products for MRPL50:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
MRPL50 for ontologies About GeneDecksing
MRPL50 Antibody Products:
Assay Products for MRPL50: |
Protein
Domains /
Families
for MRPL50 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPL50 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8N5N7ProtoNet protein and cluster: Q8N5N7 |
Function
for MRPL50 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL50 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL50
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: MRPL50 (NM_019051) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL50 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL50 |
|
Pathways & Interactions
for MRPL50 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL50
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/231 Interacting proteins for MRPL50 (Q8N5N72, 3 ENSP000003639994) via UniProtKB, MINT, STRING, and/or I2D (see all 231)About this table
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Drugs & Compounds
for MRPL50 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPL50
Search CenterWatch for drugs/clinical trials and news about MRPL50 / RM50
|
Transcripts
for MRPL50 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPL50 gene: NM_019051.2 Unigene Cluster for MRPL50: Mitochondrial ribosomal protein L50 Hs.288224 [show with all ESTs]Unigene Representative Sequence: BE8935342 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000374865(uc011lvj.2 uc004bbe.2) ENST00000539624
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL50 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL50
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRPL50 (NM_019051) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL50 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL50 |
Additional cDNA sequence: AK000500.1 AK295521.1 BC032008.1 5 DOTS entries: DT.100711166 DT.40316179 DT.91751536 DT.116257 DT.95076186 24/202 AceView cDNA sequences (see all 202): AV726160 BM449893 AI334212 AA887117 AA873883 NM_019051 AI435584 AA887456 AA871989 AA843650 AA353433 BG117373 CB250587 AV728528 CA775339 BM477571 AA872002 W47143 BQ008232 BX498347 W92984 BM785513 AL705574 AI192446
GeneLoc Exon Structure
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Expression
for MRPL50 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPL50 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAATACTA
About this image
See MRPL50 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPL50
SOURCE GeneReport for Unigene cluster: Hs.288224
SABiosciences Custom PCR Arrays for MRPL50
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL50
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL50 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL50 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL50 |
Orthologs
for MRPL50 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for MRPL50 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for MRPL50 (if available)
TreeFam Gene Tree for MRPL50 (if available) |
Paralogs
for MRPL50 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for MRPL50 gene
MRPL50 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for MRPL50
PGOHUM00000238498 PGOHUM00000240012 PGOHUM00000240492 PGOHUM00000235858
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Genomic Variants
for MRPL50 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for MRPL50 (104149915 - 104160919 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MRPL50: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL50 |
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Disorders
/ Diseases
for MRPL50 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRPL50 for disorders About MalaCards
MRPL50 for disorders About GeneDecksing
OMIM gene information: 611854
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MRPL50 (1 document)
Export disorders for MRPL50 gene to outside databases
|
Publications
for MRPL50 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPL50 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with MRPL50) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- A data set of human endogenous protein ubiquitination sites. (PubMed id 20972266)1 Shi Y....Qin J. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
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External Searches for MRPL50 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MRPL50 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPL50 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPL50 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPL50 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for MRPL50 gene:
Search GeneIP for patents involving MRPL50
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPL50 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for MRPL50 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for MRPL50 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL50 | | | OriGene Protein Over-expression Lysate for MRPL50 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for MRPL50 | | OriGene 3'-UTR Clone for MRPL50 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL50 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL50 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for MRPL50 | | OriGene Custom Protein Services for MRPL50 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPL50 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL50 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL50 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPL50 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL50 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL50 |
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| | | | Search Tocris compounds for MRPL50 |
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 | | | MRPL50 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for MRPL50 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL50 |
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