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Aliases for MRPL50 Gene

Aliases for MRPL50 Gene

  • Mitochondrial Ribosomal Protein L50 2 3
  • Mitochondrial 39S Ribosomal Protein L50 2 3
  • MRP-L50 3 4
  • L50mt 3 4
  • 39S Ribosomal Protein L50, Mitochondrial 3

External Ids for MRPL50 Gene

Summaries for MRPL50 Gene

Entrez Gene Summary for MRPL50 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a putative 39S subunit protein and belongs to the L47P ribosomal protein family. Pseudogenes corresponding to this gene are found on chromosomes 2p, 2q, 5p, and 10q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL50 Gene

MRPL50 (Mitochondrial Ribosomal Protein L50) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL50 Gene

Genomics for MRPL50 Gene

Genomic Location for MRPL50 Gene

Start:
101,387,633 bp from pter
End:
101,398,637 bp from pter
Size:
11,005 bases
Orientation:
Minus strand

Genomic View for MRPL50 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL50 Gene

Regulatory Elements for MRPL50 Gene

Proteins for MRPL50 Gene

  • Protein details for MRPL50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5N7-RM50_HUMAN
    Recommended name:
    39S ribosomal protein L50, mitochondrial
    Protein Accession:
    Q8N5N7
    Secondary Accessions:
    • B7Z358
    • Q5T7E0
    • Q9NX15

    Protein attributes for MRPL50 Gene

    Size:
    158 amino acids
    Molecular mass:
    18325 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL50 Gene

    Alternative splice isoforms for MRPL50 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL50 Gene

Proteomics data for MRPL50 Gene at MOPED

Post-translational modifications for MRPL50 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys34 and Lys139

Other Protein References for MRPL50 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL50 Gene

Domains for MRPL50 Gene

Gene Families for MRPL50 Gene

HGNC:
  • MRPL :Mitochondrial ribosomal proteins / large subunits

Protein Domains for MRPL50 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with MRPL50: view

No data available for UniProtKB/Swiss-Prot for MRPL50 Gene

Function for MRPL50 Gene

miRNA for MRPL50 Gene

miRTarBase miRNAs that target MRPL50

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL50 Gene

Localization for MRPL50 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL50 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL50 Gene COMPARTMENTS Subcellular localization image for MRPL50 gene
Compartment Confidence
mitochondrion 3
cytosol 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MRPL50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL50: view

Pathways for MRPL50 Gene

SuperPathways for MRPL50 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRPL50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL50: view

No data available for Pathways by source for MRPL50 Gene

Transcripts for MRPL50 Gene

mRNA/cDNA for MRPL50 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(202) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRPL50 Gene

Mitochondrial ribosomal protein L50:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL50 Gene

No ASD Table

Relevant External Links for MRPL50 Gene

GeneLoc Exon Structure for
MRPL50
ECgene alternative splicing isoforms for
MRPL50

Expression for MRPL50 Gene

mRNA expression in normal human tissues for MRPL50 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL50 Gene

SOURCE GeneReport for Unigene cluster for MRPL50 Gene Hs.288224

genes like me logo Genes that share expressions with MRPL50: view

Orthologs for MRPL50 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPL50 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL50 36
  • 98.73 (n)
  • 98.1 (a)
MRPL50 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL50 36
  • 84.18 (n)
  • 77.22 (a)
MRPL50 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL50 36
  • 84.18 (n)
  • 79.11 (a)
MRPL50 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl50 36
  • 78.9 (n)
  • 74.05 (a)
Mrpl50 16
Mrpl50 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPL50 37
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL50 37
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl50 36
  • 79.54 (n)
  • 73.42 (a)
chicken
(Gallus gallus)
Aves MRPL50 36
  • 54.99 (n)
  • 50.96 (a)
MRPL50 37
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL50 37
  • 48 (a)
OneToOne
Species with no ortholog for MRPL50:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRPL50 Gene

ENSEMBL:
Gene Tree for MRPL50 (if available)
TreeFam:
Gene Tree for MRPL50 (if available)

Paralogs for MRPL50 Gene

Pseudogenes.org Pseudogenes for MRPL50 Gene

genes like me logo Genes that share paralogs with MRPL50: view

No data available for Paralogs for MRPL50 Gene

Variants for MRPL50 Gene

Sequence variations from dbSNP and Humsavar for MRPL50 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs8131 - 101,390,564(-) ATGTT(C/T)TTGAT reference, missense
rs3739718 -- 101,390,361(+) AGAGA(A/G)CAGTT utr-variant-3-prime
rs10116908 -- 101,392,058(+) gctcc(A/C)aaatg intron-variant
rs10118966 -- 101,389,873(+) TGGCA(C/T)ATATT downstream-variant-500B
rs10989486 -- 101,390,873(+) AAACA(C/G)ACAAA intron-variant

Relevant External Links for MRPL50 Gene

HapMap Linkage Disequilibrium report
MRPL50

No data available for Structural Variations from Database of Genomic Variants (DGV) for MRPL50 Gene

Disorders for MRPL50 Gene

Relevant External Links for MRPL50

Genetic Association Database (GAD)
MRPL50
Human Genome Epidemiology (HuGE) Navigator
MRPL50
genes like me logo Genes that share disorders with MRPL50: view

No data available for UniProtKB/Swiss-Prot for MRPL50 Gene

Publications for MRPL50 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PMID: 20186120) Richter R. … Chrzanowska-Lightowlers Z.M. (EMBO J. 2010) 3

Products for MRPL50 Gene

  • antibodies-online proteins for MRPL50
  • antibodies-online antibodies for MRPL50
  • antibodies-online kits for MRPL50

Sources for MRPL50 Gene

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