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Aliases for MRPL50 Gene

Aliases for MRPL50 Gene

  • Mitochondrial Ribosomal Protein L50 2 3 5
  • Mitochondrial 39S Ribosomal Protein L50 2 3
  • MRP-L50 3 4
  • L50mt 3 4
  • 39S Ribosomal Protein L50, Mitochondrial 3

External Ids for MRPL50 Gene

Previous GeneCards Identifiers for MRPL50 Gene

  • GC09M094952
  • GC09M095895
  • GC09M097609
  • GC09M099532
  • GC09M101231
  • GC09M103189
  • GC09M104149
  • GC09M073751

Summaries for MRPL50 Gene

Entrez Gene Summary for MRPL50 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a putative 39S subunit protein and belongs to the L47P ribosomal protein family. Pseudogenes corresponding to this gene are found on chromosomes 2p, 2q, 5p, and 10q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL50 Gene

MRPL50 (Mitochondrial Ribosomal Protein L50) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL50 Gene

Genomics for MRPL50 Gene

Regulatory Elements for MRPL50 Gene

Enhancers for MRPL50 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around MRPL50 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL50 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for MRPL50 Gene

101,387,633 bp from pter
101,398,641 bp from pter
11,009 bases
Minus strand

Genomic View for MRPL50 Gene

Genes around MRPL50 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL50 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL50 Gene

Proteins for MRPL50 Gene

  • Protein details for MRPL50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L50, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B7Z358
    • Q5T7E0
    • Q9NX15

    Protein attributes for MRPL50 Gene

    158 amino acids
    Molecular mass:
    18325 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL50 Gene

    Alternative splice isoforms for MRPL50 Gene


neXtProt entry for MRPL50 Gene

Post-translational modifications for MRPL50 Gene

  • Ubiquitination at Lys 34 and Lys 139
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL50 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL50 Gene

Domains & Families for MRPL50 Gene

Gene Families for MRPL50 Gene

Protein Domains for MRPL50 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPL50: view

No data available for UniProtKB/Swiss-Prot for MRPL50 Gene

Function for MRPL50 Gene

Phenotypes for MRPL50 Gene

GenomeRNAi human phenotypes for MRPL50:
genes like me logo Genes that share phenotypes with MRPL50: view

Animal Model Products

CRISPR Products

miRNA for MRPL50 Gene

miRTarBase miRNAs that target MRPL50

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL50 Gene

Localization for MRPL50 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL50 Gene


Subcellular locations from

Jensen Localization Image for MRPL50 Gene COMPARTMENTS Subcellular localization image for MRPL50 gene
Compartment Confidence
mitochondrion 5
cytosol 3
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MRPL50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPL50: view

Pathways & Interactions for MRPL50 Gene

genes like me logo Genes that share pathways with MRPL50: view

Gene Ontology (GO) - Biological Process for MRPL50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL50: view

No data available for SIGNOR curated interactions for MRPL50 Gene

Drugs & Compounds for MRPL50 Gene

No Compound Related Data Available

Transcripts for MRPL50 Gene

mRNA/cDNA for MRPL50 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(202) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRPL50 Gene

Mitochondrial ribosomal protein L50:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL50 Gene

No ASD Table

Relevant External Links for MRPL50 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL50 Gene

mRNA expression in normal human tissues for MRPL50 Gene

Protein differential expression in normal tissues from HIPED for MRPL50 Gene

This gene is overexpressed in Lung (14.9), Peripheral blood mononuclear cells (10.9), Pancreas (9.9), and CD8 Tcells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPL50 Gene

Protein tissue co-expression partners for MRPL50 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPL50 Gene:


SOURCE GeneReport for Unigene cluster for MRPL50 Gene:

genes like me logo Genes that share expression patterns with MRPL50: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL50 Gene

Orthologs for MRPL50 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPL50 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPL50 34
  • 84.18 (n)
  • 77.22 (a)
MRPL50 35
  • 75 (a)
(Canis familiaris)
Mammalia MRPL50 34
  • 84.18 (n)
  • 79.11 (a)
MRPL50 35
  • 77 (a)
(Mus musculus)
Mammalia Mrpl50 34
  • 78.9 (n)
  • 74.05 (a)
Mrpl50 16
Mrpl50 35
  • 77 (a)
(Pan troglodytes)
Mammalia MRPL50 34
  • 98.73 (n)
  • 98.1 (a)
MRPL50 35
  • 98 (a)
(Rattus norvegicus)
Mammalia Mrpl50 34
  • 79.54 (n)
  • 73.42 (a)
(Monodelphis domestica)
Mammalia MRPL50 35
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL50 35
  • 59 (a)
(Gallus gallus)
Aves MRPL50 34
  • 54.99 (n)
  • 50.96 (a)
MRPL50 35
  • 48 (a)
(Anolis carolinensis)
Reptilia MRPL50 35
  • 48 (a)
Species where no ortholog for MRPL50 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRPL50 Gene

Gene Tree for MRPL50 (if available)
Gene Tree for MRPL50 (if available)

Paralogs for MRPL50 Gene Pseudogenes for MRPL50 Gene

genes like me logo Genes that share paralogs with MRPL50: view

No data available for Paralogs for MRPL50 Gene

Variants for MRPL50 Gene

Sequence variations from dbSNP and Humsavar for MRPL50 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs8131 - 101,390,564(-) ATGTT(C/T)TTGAT nc-transcript-variant, reference, missense
rs10116908 -- 101,392,058(+) gctcc(A/C)aaatg intron-variant
rs10118966 -- 101,389,873(+) TGGCA(C/T)ATATT nc-transcript-variant, downstream-variant-500B
rs117534692 -- 101,388,657(+) TGCCC(C/T)CTAGA nc-transcript-variant
rs118189976 -- 101,387,528(+) ATTAT(A/G)AGCGG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for MRPL50 Gene

Variant ID Type Subtype PubMed ID
nsv475056 CNV novel sequence insertion 20440878
nsv481376 CNV novel sequence insertion 20440878
nsv972437 CNV duplication 23825009

Variation tolerance for MRPL50 Gene

Residual Variation Intolerance Score: 82.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.14; 69.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL50 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL50 Gene

Disorders for MRPL50 Gene

Relevant External Links for MRPL50

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MRPL50 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL50 Gene

Publications for MRPL50 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 65

Products for MRPL50 Gene

Sources for MRPL50 Gene

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