Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPL50 Gene

Aliases for MRPL50 Gene

  • Mitochondrial Ribosomal Protein L50 2 3 5
  • Mitochondrial 39S Ribosomal Protein L50 2 3
  • MRP-L50 3 4
  • L50mt 3 4

External Ids for MRPL50 Gene

Previous GeneCards Identifiers for MRPL50 Gene

  • GC09M094952
  • GC09M095895
  • GC09M097609
  • GC09M099532
  • GC09M101231
  • GC09M103189
  • GC09M104149
  • GC09M073751

Summaries for MRPL50 Gene

Entrez Gene Summary for MRPL50 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a putative 39S subunit protein and belongs to the L47P ribosomal protein family. Pseudogenes corresponding to this gene are found on chromosomes 2p, 2q, 5p, and 10q. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL50 Gene

MRPL50 (Mitochondrial Ribosomal Protein L50) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL50 Gene

Genomics for MRPL50 Gene

Regulatory Elements for MRPL50 Gene

Enhancers for MRPL50 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MRPL50 on UCSC Golden Path with GeneCards custom track

Promoters for MRPL50 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL50 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL50 Gene

Chromosome:
9
Start:
101,387,633 bp from pter
End:
101,398,641 bp from pter
Size:
11,009 bases
Orientation:
Minus strand

Genomic View for MRPL50 Gene

Genes around MRPL50 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL50 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL50 Gene

Proteins for MRPL50 Gene

  • Protein details for MRPL50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N5N7-RM50_HUMAN
    Recommended name:
    39S ribosomal protein L50, mitochondrial
    Protein Accession:
    Q8N5N7
    Secondary Accessions:
    • B7Z358
    • Q5T7E0
    • Q9NX15

    Protein attributes for MRPL50 Gene

    Size:
    158 amino acids
    Molecular mass:
    18325 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MRPL50 Gene

    Alternative splice isoforms for MRPL50 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL50 Gene

Proteomics data for MRPL50 Gene at MOPED

Post-translational modifications for MRPL50 Gene

  • Ubiquitination at Lys 34 and Lys 139
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL50 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL50 Gene

Domains & Families for MRPL50 Gene

Gene Families for MRPL50 Gene

Protein Domains for MRPL50 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MRPL50: view

No data available for UniProtKB/Swiss-Prot for MRPL50 Gene

Function for MRPL50 Gene

Animal Model Products

miRNA for MRPL50 Gene

miRTarBase miRNAs that target MRPL50

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL50 Gene

Localization for MRPL50 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL50 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL50 Gene COMPARTMENTS Subcellular localization image for MRPL50 gene
Compartment Confidence
mitochondrion 5
cytosol 3
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MRPL50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with MRPL50: view

Pathways & Interactions for MRPL50 Gene

genes like me logo Genes that share pathways with MRPL50: view

Gene Ontology (GO) - Biological Process for MRPL50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPL50: view

No data available for SIGNOR curated interactions for MRPL50 Gene

Drugs & Compounds for MRPL50 Gene

No Compound Related Data Available

Transcripts for MRPL50 Gene

mRNA/cDNA for MRPL50 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(202) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MRPL50 Gene

Mitochondrial ribosomal protein L50:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL50 Gene

No ASD Table

Relevant External Links for MRPL50 Gene

GeneLoc Exon Structure for
MRPL50
ECgene alternative splicing isoforms for
MRPL50

Expression for MRPL50 Gene

mRNA expression in normal human tissues for MRPL50 Gene

Protein differential expression in normal tissues from HIPED for MRPL50 Gene

This gene is overexpressed in Lung (14.9), Peripheral blood mononuclear cells (10.9), Pancreas (9.9), and CD8 Tcells (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL50 Gene



SOURCE GeneReport for Unigene cluster for MRPL50 Gene Hs.288224

genes like me logo Genes that share expression patterns with MRPL50: view

Protein tissue co-expression partners for MRPL50 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL50 Gene

Orthologs for MRPL50 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MRPL50 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MRPL50 35
  • 84.18 (n)
  • 77.22 (a)
MRPL50 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL50 35
  • 84.18 (n)
  • 79.11 (a)
MRPL50 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl50 35
  • 78.9 (n)
  • 74.05 (a)
Mrpl50 16
Mrpl50 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MRPL50 35
  • 98.73 (n)
  • 98.1 (a)
MRPL50 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl50 35
  • 79.54 (n)
  • 73.42 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPL50 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL50 36
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPL50 35
  • 54.99 (n)
  • 50.96 (a)
MRPL50 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL50 36
  • 48 (a)
OneToOne
Species with no ortholog for MRPL50:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MRPL50 Gene

ENSEMBL:
Gene Tree for MRPL50 (if available)
TreeFam:
Gene Tree for MRPL50 (if available)

Paralogs for MRPL50 Gene

Pseudogenes.org Pseudogenes for MRPL50 Gene

genes like me logo Genes that share paralogs with MRPL50: view

No data available for Paralogs for MRPL50 Gene

Variants for MRPL50 Gene

Sequence variations from dbSNP and Humsavar for MRPL50 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs8131 - 101,390,564(-) ATGTT(C/T)TTGAT nc-transcript-variant, reference, missense
rs7847420 -- 101,387,855(+) TATGT(C/T)TGATT intron-variant
rs113119762 -- 101,393,490(+) CATAC(A/G)TAAGA intron-variant
rs113392642 -- 101,394,743(+) GCAAC(A/G)ACTTC intron-variant
rs113453859 -- 101,392,272(+) CAAAT(A/C)CAAAA intron-variant

Variation tolerance for MRPL50 Gene

Residual Variation Intolerance Score: 82.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.14; 69.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL50 Gene

HapMap Linkage Disequilibrium report
MRPL50

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPL50 Gene

Disorders for MRPL50 Gene

Relevant External Links for MRPL50

Genetic Association Database (GAD)
MRPL50
Human Genome Epidemiology (HuGE) Navigator
MRPL50
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL50

No disorders were found for MRPL50 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL50 Gene

Publications for MRPL50 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PMID: 23402259) Chen R. … Zhang N. (J. Proteome Res. 2013) 3

Products for MRPL50 Gene

Sources for MRPL50 Gene

Content