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MRPL49 Gene

protein-coding   GIFtS: 50
GCID: GC11P064889

Mitochondrial Ribosomal Protein L49

(Previous name: chromosome 11 open reading frame 4)
(Previous symbol: C11orf4)
  See MRPL49-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Mitochondrial Ribosomal Protein L491 2     MRP-L492 3
C11orf41 2 3     NOF2 3
Neighbor Of FAU1 2 3     Chromosome 11 Open Reading Frame 41
NOF12 3 5     39S Ribosomal Protein L49, Mitochondrial2
Next To FAU1 2     Protein NOF13
L49mt2 3     

External Ids:    HGNC: 11761   Entrez Gene: 7402   Ensembl: ENSG000001497927   OMIM: 6068665   UniProtKB: Q134053   

Export aliases for MRPL49 gene to outside databases

Previous GC identifers: GC11P067405 GC11P066571 GC11P065139 GC11P064665 GC11P064646 GC11P061216


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for MRPL49 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. Pseudogenes
corresponding to this gene are found on chromosomes 5q and 8p. (provided by RefSeq, May 2011)

GeneCards Summary for MRPL49 Gene:
MRPL49 (mitochondrial ribosomal protein L49) is a protein-coding gene. Diseases associated with MRPL49 include glossopharyngeal neuralgia. GO annotations related to this gene include structural constituent of ribosome.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the MRPL49 gene promoter:
         HEN1   GR   AP-1   GR-beta   GR-alpha   ATF   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidMRPL49 promoter sequence
   Search Chromatin IP Primers for MRPL49

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat MRPL49


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

MRPL49 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MRPL49 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064889:  view genomic region     (about GC identifiers)

Start:
64,889,655 bp from pter      End:
64,894,843 bp from pter
Size:
5,189 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for MRPL49

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RM49_HUMAN, Q13405 (See protein sequence)
Recommended Name: 39S ribosomal protein L49, mitochondrial  
Size: 166 amino acids; 19198 Da
Subunit: Interacts with OXA1L (By similarity)
Secondary accessions: B2R4G6

Explore the universe of human proteins at neXtProt for MRPL49: NX_Q13405

Explore proteomics data for MRPL49 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See MRPL49 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004918.1  
    ENSEMBL proteins: 
     ENSP00000434222   ENSP00000434190   ENSP00000437177   ENSP00000279242   ENSP00000436740  
     ENSP00000434052  

    MRPL49 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Protein Over-expression Lysate for MRPL49
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    Novus Biologicals MRPL49 Proteins
    Novus Biologicals MRPL49 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for MRPL49

     
    Search eBioscience for Proteins for MRPL49 

    MRPL49 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for MRPL49
    Cloud-Clone Corp. Antibodies for MRPL49
    Search ThermoFisher Antibodies for MRPL49
    LSBio Antibodies in human, mouse, rat for MRPL49

    MRPL49 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for MRPL49
    Cloud-Clone Corp. CLIAs for MRPL49
    Search eBioscience for ELISAs for MRPL49 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MRPL: Mitochondrial ribosomal proteins / large subunits

    1 InterPro protein domain:
     IPR007740 Ribosomal_L49/IMG2

    Graphical View of Domain Structure for InterPro Entry Q13405

    ProtoNet protein and cluster: Q13405

    1 Blocks protein domain: IPB007740 Mitochondrial large ribosomal subunit

    UniProtKB/Swiss-Prot: RM49_HUMAN, Q13405
    Similarity: Belongs to the ribosomal protein L49em family


    Find genes that share domains with MRPL49           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003735structural constituent of ribosome IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with MRPL49           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for MRPL49:
     Increased cell death in DLD-1   Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for MRPL49
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for MRPL49

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for MRPL49
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for MRPL49

    miRNA
    Products:
        
    miRTarBase miRNAs that target MRPL49:
    hsa-mir-93-3p (MIRT038871), hsa-mir-124-3p (MIRT022214)

    Block miRNA regulation of human, mouse, rat MRPL49 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MRPL49 (see all 17):
    hsa-let-7a-2* hsa-miR-633 hsa-let-7g* hsa-miR-548x hsa-miR-33b hsa-miR-548am hsa-miR-548d-3p hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidMRPL49 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for MRPL49
    Predesigned siRNA for gene silencing in human, mouse, rat MRPL49

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: MRPL49 (NM_004927)
    Sino Biological Human cDNA Clone for MRPL49
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRPL49
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL49

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for MRPL49
    Browse ESI BIO Cell Lines and PureStem Progenitors for MRPL49 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL49


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RM49_HUMAN, Q13405: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005739mitochondrion ----
    GO:0005761mitochondrial ribosome IDA--
    GO:0005840ribosome ----

    Find genes that share ontologies with MRPL49           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for MRPL49
    Interactions:

        Search GeneGlobe Interaction Network for MRPL49

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for MRPL49 (Q134052, 3 ENSP000002792424) via UniProtKB, MINT, STRING, and/or I2D (see all 255)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    OXA1LQ150703, ENSP000002858484I2D: score=1 STRING: ENSP00000285848
    MRPL19P494062, ENSP000003774864MINT-8079030 STRING: ENSP00000377486
    MRPL3P090012, ENSP000002649954MINT-8079030 STRING: ENSP00000264995
    MRPL47Q9HD332, ENSP000004176024MINT-8079030 STRING: ENSP00000417602
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation IEA--

    Find genes that share ontologies with MRPL49           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for MRPL49 (RM49)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for MRPL49 gene: 
    NM_004927.3  

    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524482(uc021qle.1) ENST00000528529 ENST00000534078 ENST00000526319
    ENST00000526171 ENST00000279242(uc001oda.2 uc021qlf.1) ENST00000531705
    ENST00000533943 ENST00000532671
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat MRPL49 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate MRPL49 (see all 17):
    hsa-let-7a-2* hsa-miR-633 hsa-let-7g* hsa-miR-548x hsa-miR-33b hsa-miR-548am hsa-miR-548d-3p hsa-miR-3922-3p
    SwitchGear 3'UTR luciferase reporter plasmidMRPL49 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for MRPL49
    Predesigned siRNA for gene silencing in human, mouse, rat MRPL49
    Clone
    Products:
         
    OriGene clones in human, mouse for MRPL49 (see all 6)
    OriGene ORF clones in mouse, rat for MRPL49
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: MRPL49 (NM_004927)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for MRPL49
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL49
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for MRPL49
    OriGene qSTAR qPCR primer pairs in human, mouse for MRPL49
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat MRPL49
      QuantiTect SYBR Green Assays in human, mouse, rat MRPL49
      QuantiFast Probe-based Assays in human, mouse, rat MRPL49

    Selected AceView cDNA sequences (see all 687):

    BQ128251 CF131495 AI985273 AU280211 AI653127 AW237488 BC029825 AL556200 
    BU192430 BQ776004 AI738651 AI242572 BQ689893 AI918269 BQ685808 AI919118 
    AI049653 BQ690084 AA378334 BU070969 BU944592 BQ678659 AI869263 CB151362 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    MRPL49 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAACCCTCA
    MRPL49 Expression
    About this image

    MRPL49 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    MRPL49 Protein Expression

    UniProtKB/Swiss-Prot: RM49_HUMAN, Q13405
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for MRPL49
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    QuantiFast Probe-based Assays in human, mouse, rat MRPL49
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL49

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for MRPL49 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Mrpl491 , 5 mitochondrial ribosomal protein L491, 5 82.73(n)1
    83.13(a)1
      19 (4.34 cM)5
    181201  NM_026246.31  NP_080522.11 
     60536305 
    chicken
    (Gallus gallus)
    Aves MRPL491 mitochondrial ribosomal protein L49 63.45(n)
    55.42(a)
      100858532  XM_003643505.2  XP_003643553.2 
    lizard
    (Anolis carolinensis)
    Reptilia MRPL496
    mitochondrial ribosomal protein L49
    71(a)
    1 ↔ 1
    GL344606.1(1170-5601)
    African clawed frog
    (Xenopus laevis)
    Amphibia AW635120.12   -- 74.65(n)    AW635120.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.136242 Transcribed sequence with weak similarity to protein more 74.85(n)    BI867192.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpL496
    mitochondrial ribosomal protein L49
    32(a)
    1 ↔ 1
    X(12801139-12801877)
    worm
    (Caenorhabditis elegans)
    Secernentea mrpl-496
    Protein MRPL-49 (mrpl-49) mRNA, complete cds
    27(a)
    1 ↔ 1
    V(12728631-12729415) WBGene00011247


    ENSEMBL Gene Tree for MRPL49 (if available)
    TreeFam Gene Tree for MRPL49 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for MRPL49 gene

    Find genes that share paralogs with MRPL49           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for MRPL49
    PGOHUM00000251370 PGOHUM00000249581


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for MRPL49 (see all 71)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1400603971,2
    --64891763(+) GAACTC/GTCTCT 3 -- int10--------
    rs1851511811,2
    --64891773(+) TTCGTA/GGCCCT 3 -- int10--------
    rs1902488581,2
    --64891860(+) CCAGCC/GTTTTA 3 -- int10--------
    rs1811320381,2
    C--64891938(+) GGGTAA/GGCTAA 3 -- int10--------
    rs2013534251,2
    C--64891972(+) GCTTCA/GGAGCC 3 -- spa1 int10--------
    rs115463651,2
    H--64892028(+) ATGAAT/CATCAG 4 /H /Y mis1 int1 ese34Minor allele frequency- C:0.00NS EA 406
    rs1424869481,2
    C,F--64892043(+) TGGAGC/TGCCTG 4 R C mis1 int11Minor allele frequency- T:0.00NA 4552
    rs2011735111,2
    C--64892054(+) TTACCA/GGCTAC 4 P syn1 int10--------
    rs1502930821,2
    C--64892057(+) CCGGCC/TACCAG 4 A syn1 int10--------
    rs1178536401,2
    F--64892186(+) AGAGGT/CTGGCC 3 -- int11Minor allele frequency- C:0.01EA 120

    HapMap Linkage Disequilibrium report for MRPL49 (64889655 - 64894843 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for MRPL49:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1174n71CNV Loss21882294
    nsv526181CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing MRPL49
    DNA2.0 Custom Variant and Variant Library Synthesis for MRPL49

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606866    OMIM disorders: --

    1 disease for MRPL49:    
    About MalaCards
    glossopharyngeal neuralgia

    1 disease from the University of Copenhagen DISEASES database for MRPL49:
    Glossopharyngeal neuralgia

    Find genes that share disorders with MRPL49           About GenesLikeMe

    Genetic Association Database (GAD): MRPL49
    Human Genome Epidemiology (HuGE) Navigator: MRPL49 (1 document)

    Export disorders for MRPL49 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for MRPL49 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with MRPL49)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, cDNA, and genomic structure of a conserved gene (NOF) at chromosome 11q13 next to FAU and oriented in the opposite transcriptional orientation. (PubMed id 8786148)1, 2, 3, 9 Kas K.... Merregaert J. (Genomics 1996)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PubMed id 11551941)1, 2 Koc E.C.... Spremulli L.L. (J. Biol. Chem. 2001)
    6. Quantitative study of the interactome of PKCIP involved in the EGF-induced tumor cell chemotaxis. (PubMed id 23402259)1 Chen R....Zhang N. (J. Proteome Res. 2013)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. Biochemical and phosphoproteomic analysis of the helix-loop-helix protein E47. (PubMed id 22354994)1 Teachenor R....Murre C. (Mol. Cell. Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 740 HGNC: 1176 AceView: MRPL49 Ensembl:ENSG00000149792 euGenes: HUgn740
    ECgene: MRPL49 H-InvDB: MRPL49

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for MRPL49 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for MRPL49 gene:
    Search GeneIP for patents involving MRPL49

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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