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Aliases for MRPL47 Gene

Aliases for MRPL47 Gene

  • Mitochondrial Ribosomal Protein L47 2 3
  • Nasopharyngeal Carcinoma Metastasis-Related Protein 1 3 4
  • Nasopharyngeal Carcinoma Metastasis-Related 1 2 3
  • MRP-L47 3 4
  • L47mt 3 4
  • NCM1 3 4
  • 39S Ribosomal Protein L47, Mitochondrial 3
  • CGI-204 3

External Ids for MRPL47 Gene

Previous GeneCards Identifiers for MRPL47 Gene

  • GC03M176055
  • GC03M180148
  • GC03M180708
  • GC03M180627
  • GC03M180788
  • GC03M179306
  • GC03M176710

Summaries for MRPL47 Gene

Entrez Gene Summary for MRPL47 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene is immediately adjacent to the gene for BAF complex 53 kDa subunit protein a (BAF53a), in a tail-to-tail orientation. Two transcript variants encoding different protein isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL47 Gene

MRPL47 (Mitochondrial Ribosomal Protein L47) is a Protein Coding gene. Diseases associated with MRPL47 include nasopharyngeal carcinoma. GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL47 Gene

Genomics for MRPL47 Gene

Regulatory Elements for MRPL47 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPL47 Gene

179,588,285 bp from pter
179,604,654 bp from pter
16,370 bases
Minus strand

Genomic View for MRPL47 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL47 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL47 Gene

Proteins for MRPL47 Gene

  • Protein details for MRPL47 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L47, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • Q6XRG1
    • Q8N5D1

    Protein attributes for MRPL47 Gene

    250 amino acids
    Molecular mass:
    29450 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG01157.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. Seems to include a portion of the orthologous murine sequence.; Evidence={ECO:0000305}; Sequence=AAO92749.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL47 Gene

    Alternative splice isoforms for MRPL47 Gene


neXtProt entry for MRPL47 Gene

Proteomics data for MRPL47 Gene at MOPED

Post-translational modifications for MRPL47 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL47 Gene

No data available for DME Specific Peptides for MRPL47 Gene

Domains for MRPL47 Gene

Gene Families for MRPL47 Gene

Protein Domains for MRPL47 Gene

Suggested Antigen Peptide Sequences for MRPL47 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L47em family.
  • Belongs to the ribosomal protein L47em family.
genes like me logo Genes that share domains with MRPL47: view

Function for MRPL47 Gene

Gene Ontology (GO) - Molecular Function for MRPL47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003735 structural constituent of ribosome IBA --
genes like me logo Genes that share ontologies with MRPL47: view

Phenotypes for MRPL47 Gene

GenomeRNAi human phenotypes for MRPL47:
genes like me logo Genes that share phenotypes with MRPL47: view

Animal Model Products

miRNA for MRPL47 Gene

miRTarBase miRNAs that target MRPL47

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL47

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPL47 Gene

Localization for MRPL47 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL47 Gene


Subcellular locations from

Jensen Localization Image for MRPL47 Gene COMPARTMENTS Subcellular localization image for MRPL47 gene
Compartment Confidence
mitochondrion 5
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRPL47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005761 mitochondrial ribosome --
GO:0005762 mitochondrial large ribosomal subunit IBA --
genes like me logo Genes that share ontologies with MRPL47: view

Pathways for MRPL47 Gene

SuperPathways for MRPL47 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRPL47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation --
GO:0006996 organelle organization TAS --
GO:0008150 biological_process ND --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPL47: view

No data available for Pathways by source for MRPL47 Gene

Transcripts for MRPL47 Gene

mRNA/cDNA for MRPL47 Gene

Unigene Clusters for MRPL47 Gene

Mitochondrial ribosomal protein L47:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL47

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL47 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: -
SP3: - -

Relevant External Links for MRPL47 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL47 Gene

mRNA expression in normal human tissues for MRPL47 Gene

Protein differential expression in normal tissues for MRPL47 Gene

This gene is overexpressed in Pancreas (10.6), Liver (9.6), and Peripheral blood mononuclear cells (9.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL47 Gene

SOURCE GeneReport for Unigene cluster for MRPL47 Gene Hs.283734

genes like me logo Genes that share expressions with MRPL47: view

Expression partners for MRPL47 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL47 Gene

Orthologs for MRPL47 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL47 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPL47 35
  • 85.75 (n)
  • 84.27 (a)
MRPL47 36
  • 83 (a)
(Canis familiaris)
Mammalia MRPL47 35
  • 87.6 (n)
  • 81.2 (a)
MRPL47 36
  • 81 (a)
(Mus musculus)
Mammalia Mrpl47 35
  • 80.8 (n)
  • 77.6 (a)
Mrpl47 16
Mrpl47 36
  • 77 (a)
(Pan troglodytes)
Mammalia MRPL47 35
  • 99.6 (n)
  • 98.8 (a)
MRPL47 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mrpl47 35
  • 79.73 (n)
  • 77.2 (a)
(Monodelphis domestica)
Mammalia MRPL47 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL47 36
  • 60 (a)
(Gallus gallus)
Aves MRPL47 35
  • 60.32 (n)
  • 55.87 (a)
MRPL47 36
  • 55 (a)
(Anolis carolinensis)
Reptilia MRPL47 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl47 35
  • 60.87 (n)
  • 56.09 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5541 35
(Danio rerio)
Actinopterygii idibd1090 35
LOC557789 35
  • 63.44 (n)
  • 62.37 (a)
mrpl47 36
  • 50 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002218 35
  • 47.73 (n)
  • 44.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL47 35
  • 45.81 (n)
  • 41.23 (a)
Rlc1 36
  • 30 (a)
(Caenorhabditis elegans)
Secernentea mrpl-47 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.134 36
  • 43 (a)
Species with no ortholog for MRPL47:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL47 Gene

Gene Tree for MRPL47 (if available)
Gene Tree for MRPL47 (if available)

Paralogs for MRPL47 Gene

No data available for Paralogs for MRPL47 Gene

Variants for MRPL47 Gene

Sequence variations from dbSNP and Humsavar for MRPL47 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1052879 -- 179,588,962(+) TTCCG(G/T)GCTTT reference, synonymous-codon
rs1320221 -- 179,590,654(+) CTGTA(A/G)ACAAG intron-variant
rs2339842 -- 179,590,016(+) GTGAT(A/G)CTGGA intron-variant
rs2339843 -- 179,594,193(+) ATTCA(A/T)GTTAT intron-variant
rs2879605 -- 179,590,107(+) AGGCC(A/G)AGGTG intron-variant

Relevant External Links for MRPL47 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPL47 Gene

Disorders for MRPL47 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MRPL47 Gene in MalaCards »

(1) Disease for MRPL47 Gene

(1) University of Copenhagen DISEASES for MRPL47 Gene

Relevant External Links for MRPL47

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MRPL47: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for MRPL47 Gene

Publications for MRPL47 Gene

  1. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. GRSF1 regulates RNA processing in mitochondrial RNA granules. (PMID: 23473034) Jourdain A.A. … Martinou J.C. (Cell Metab. 2013) 3

Products for MRPL47 Gene

Sources for MRPL47 Gene

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