MRPL47 Gene
protein-coding GIFtS: 48
GCID: GC03M179306
|
|
mitochondrial ribosomal protein L47
| |
Aliases
for MRPL47 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein L471 2 | | MRP-L472 3 | | NCM11 2 3 | | CGI-2041 | | Nasopharyngeal Carcinoma Metastasis-Related Protein 12 3 | | 39S Ribosomal Protein L47, Mitochondrial2 | | L47mt2 3 | | Nasopharyngeal Carcinoma Metastasis-Related 12 |
Export aliases for MRPL47 gene to outside databasesPrevious GC identifers: GC03M176055 GC03M180148 GC03M180708 GC03M180627 GC03M180788 GC03M176710 |
Summaries
for MRPL47 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPL47:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.This gene is immediately adjacent to the gene for BAF complex 53 kDa subunit protein a (BAF53a), in a tail-to-tailorientation. Two transcript variants encoding different protein isoforms have been identified. (provided by RefSeq,Jul 2008)
|
Genomic Views
for MRPL47 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPL47 gene promoter:
HOXA9 HOXA9B GR GR-beta Evi-1 Meis-1b FOXJ2 (long isoform) FOXJ2 GR-alpha Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPL47
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL47 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q26.33 Ensembl cytogenetic band: 3q26.33 HGNC cytogenetic band: 3q26.33MRPL47 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M179306: view genomic region
(about GC identifiers)
Start:
|
179,306,073 bp from pter |
End:
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179,322,442 bp from pter |
Size:
|
16,370 bases |
Orientation:
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minus strand |
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Proteins
for MRPL47 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RM47_HUMAN, Q9HD33 (See
protein sequence)Recommended Name: 39S ribosomal protein L47, mitochondrial precursor Size: 250 amino acids; 29450 Da
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAG01157.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. Seems to include a portionof the orthologous murine sequence; Sequence=AAO92749.1; Type=Erroneous initiation;
Secondary accessions: Q6XRG1 Q8N5D1Alternative splicing: 3 isoforms: Q9HD33-1 Q9HD33-2 Q9HD33-3 Explore the universe of human proteins at neXtProt for MRPL47: NX_Q9HD33
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HD33
MRPL47 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_065142.2 NP_817125.1
ENSEMBL proteins: ENSP00000417602 ENSP00000259038 ENSP00000376427
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MRPL47 for ontologies About GeneDecksing
MRPL47 Antibody Products:
Assay Products for MRPL47: |
Protein
Domains /
Families
for MRPL47 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPL47 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9HD33ProtoNet protein and cluster: Q9HD33 1 Blocks protein family: IPB010729 Mitochondrial 39-S ribosomal L47
UniProtKB/Swiss-Prot: RM47_HUMAN, Q9HD33Similarity: Belongs to the ribosomal protein L47em family |
Function
for MRPL47 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL47 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL47 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for MRPL47 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL47 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL47 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0003735 | structural constituent of ribosome |
IEA | -- |
MRPL47 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for MRPL47:
|
Pathways & Interactions
for MRPL47 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL47
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/233 Interacting proteins for MRPL47 (Q9HD332, 3 ENSP000004176024) via UniProtKB, MINT, STRING, and/or I2D (see all 233)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006412 | translation |
IEA | -- | | GO:0008150 | biological_process |
ND | -- |
MRPL47 for ontologies About GeneDecksing
|
Drugs & Compounds
for MRPL47 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPL47
Search CenterWatch for drugs/clinical trials and news about MRPL47 / RM47
|
Transcripts
for MRPL47 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPL47 gene (2 alternative transcripts): NM_020409.2 NM_177988.1 Unigene Cluster for MRPL47: Mitochondrial ribosomal protein L47 Hs.283734 [show with all ESTs]Unigene Representative Sequence: BM4552193 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000476781(uc003fjz.3 uc003fka.3 uc003fkb.3) ENST00000259038
ENST00000392659
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL47 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL47 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Additional cDNA sequence: AY212270.1 BC021575.1 BC032522.1 9 DOTS entries: DT.91997648 DT.91771213 DT.99977438 DT.100677949 DT.100731348 DT.100677962 DT.97854877 DT.121047617 DT.97796732 24/88 AceView cDNA sequences (see all 88): BM851142 BM711113 BE328829 AI689819 AI948770 AI735318 NM_020409 BM857807 BC021575 BM670614 BE883272 AA524703 AI970080 AI040005 AI079811 BQ127879 BM466952 NM_177988 BM757806 CD050738 BU175382 BG926286 AJ705552 BF316795
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for MRPL47 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for MRPL47
|
Expression
for MRPL47 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPL47 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTGCGGCCG
About this image
See MRPL47 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPL47
SOURCE GeneReport for Unigene cluster: Hs.283734
SABiosciences Custom PCR Arrays for MRPL47
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL47
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL47 |
Orthologs
for MRPL47 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for MRPL47 gene from 9/27 species (see all 27) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Mrpl471 , 5 |
mitochondrial ribosomal protein L471, 5 |
80.8(n)1
77.6(a)1 |
|
3 (15.84 cM)5
746001 NM_029017.21 NP_083293.11
327253975 |
chicken
(Gallus gallus) |
Aves |
MRPL471 |
mitochondrial ribosomal protein L47 |
59.76(n)
55.28(a) |
|
424977 XM_422785.3 XP_422785.1 |
lizard
(Anolis carolinensis) |
Reptilia |
MRPL476 |
-- |
67(a) |
1 ↔ 1 |
3(2102871-2106075) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.55412 |
Xenopus laevis transcribed sequence with weak similarity more |
80.09(n) |
|
BG515682.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
idibd10902 |
idibd1090 |
70.37(n) |
|
338277 57051055 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Rlc11 |
CG9378-PA |
45.52(n)
41.94(a) |
|
41141 NM_176433.1 NP_788610.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
mrpl-476 |
Protein MRPL-47, isoform b |
29(a) |
1 ↔ 1 |
I(5244286-5245526) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G078306 |
ribosomal protein L29 family protein |
30(a) |
1 ↔ 1 |
1(2422241-2423655) |
rice
(Oryza sativa) |
Liliopsida |
-- |
39S ribosomal protein L47, mitochondrial precursor... |
29(a) |
1 ↔ 1 |
6(1511796-1515435) |
ENSEMBL Gene Tree for MRPL47 (if available)
TreeFam Gene Tree for MRPL47 (if available) |
Paralogs
for MRPL47 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MRPL47 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPL47 (179306073 - 179322442 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MRPL47: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL47 |
|
Disorders
/ Diseases
for MRPL47 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MRPL47 for disorders About GeneDecksing
OMIM gene information: 611852
OMIM disorders: --
5  diseases for MRPL47: About MalaCardsnasopharyngitis leber hereditary optic neuropathy carcinoma genetic disease
neuropathy
1 disease from the University of Copenhagen DISEASES database for MRPL47:Leber hereditary optic neuropathy Human Genome Epidemiology (HuGE) Navigator: MRPL47 (1 document)
Export disorders for MRPL47 gene to outside databases
|
Publications
for MRPL47 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPL47 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with MRPL47) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PubMed id 11551941)1, 2, 3 Koc E.C....Spremulli L.L. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
|
External Searches for MRPL47 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MRPL47 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPL47 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPL47 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPL47 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for MRPL47 gene:
Search GeneIP for patents involving MRPL47
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPL47 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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