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Aliases for MRPL47 Gene

Aliases for MRPL47 Gene

  • Mitochondrial Ribosomal Protein L47 2 3 5
  • Nasopharyngeal Carcinoma Metastasis-Related Protein 1 3 4
  • Nasopharyngeal Carcinoma Metastasis-Related 1 2 3
  • MRP-L47 3 4
  • L47mt 3 4
  • NCM1 3 4
  • CGI-204 3

External Ids for MRPL47 Gene

Previous GeneCards Identifiers for MRPL47 Gene

  • GC03M176055
  • GC03M180148
  • GC03M180708
  • GC03M180627
  • GC03M180788
  • GC03M179306
  • GC03M176710

Summaries for MRPL47 Gene

Entrez Gene Summary for MRPL47 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene is immediately adjacent to the gene for BAF complex 53 kDa subunit protein a (BAF53a), in a tail-to-tail orientation. Two transcript variants encoding different protein isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL47 Gene

MRPL47 (Mitochondrial Ribosomal Protein L47) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. GO annotations related to this gene include structural constituent of ribosome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL47 Gene

Genomics for MRPL47 Gene

Regulatory Elements for MRPL47 Gene

Promoters for MRPL47 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL47 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL47 Gene

Chromosome:
3
Start:
179,588,285 bp from pter
End:
179,604,654 bp from pter
Size:
16,370 bases
Orientation:
Minus strand

Genomic View for MRPL47 Gene

Genes around MRPL47 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL47 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL47 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL47 Gene

Proteins for MRPL47 Gene

  • Protein details for MRPL47 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HD33-RM47_HUMAN
    Recommended name:
    39S ribosomal protein L47, mitochondrial
    Protein Accession:
    Q9HD33
    Secondary Accessions:
    • Q6XRG1
    • Q8N5D1

    Protein attributes for MRPL47 Gene

    Size:
    250 amino acids
    Molecular mass:
    29450 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG01157.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. Seems to include a portion of the orthologous murine sequence.; Evidence={ECO:0000305}; Sequence=AAO92749.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL47 Gene

    Alternative splice isoforms for MRPL47 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPL47 Gene

Proteomics data for MRPL47 Gene at MOPED

Post-translational modifications for MRPL47 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL47 Gene

No data available for DME Specific Peptides for MRPL47 Gene

Domains & Families for MRPL47 Gene

Gene Families for MRPL47 Gene

Protein Domains for MRPL47 Gene

Suggested Antigen Peptide Sequences for MRPL47 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HD33

UniProtKB/Swiss-Prot:

RM47_HUMAN :
  • Belongs to the ribosomal protein L47em family.
Family:
  • Belongs to the ribosomal protein L47em family.
genes like me logo Genes that share domains with MRPL47: view

Function for MRPL47 Gene

Phenotypes for MRPL47 Gene

genes like me logo Genes that share phenotypes with MRPL47: view

Animal Model Products

miRNA for MRPL47 Gene

miRTarBase miRNAs that target MRPL47

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL47 Gene

Localization for MRPL47 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL47 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL47 Gene COMPARTMENTS Subcellular localization image for MRPL47 gene
Compartment Confidence
mitochondrion 5
cytosol 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for MRPL47 Gene

Pathways & Interactions for MRPL47 Gene

genes like me logo Genes that share pathways with MRPL47: view

Gene Ontology (GO) - Biological Process for MRPL47 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0032543 mitochondrial translation IBA,TAS --
genes like me logo Genes that share ontologies with MRPL47: view

No data available for SIGNOR curated interactions for MRPL47 Gene

Drugs & Compounds for MRPL47 Gene

No Compound Related Data Available

Transcripts for MRPL47 Gene

mRNA/cDNA for MRPL47 Gene

Unigene Clusters for MRPL47 Gene

Mitochondrial ribosomal protein L47:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL47 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2:
SP3: - -

Relevant External Links for MRPL47 Gene

GeneLoc Exon Structure for
MRPL47
ECgene alternative splicing isoforms for
MRPL47

Expression for MRPL47 Gene

mRNA expression in normal human tissues for MRPL47 Gene

Protein differential expression in normal tissues from HIPED for MRPL47 Gene

This gene is overexpressed in Pancreas (10.6), Liver (9.6), and Peripheral blood mononuclear cells (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL47 Gene



SOURCE GeneReport for Unigene cluster for MRPL47 Gene Hs.283734

genes like me logo Genes that share expression patterns with MRPL47: view

Protein tissue co-expression partners for MRPL47 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL47 Gene

Orthologs for MRPL47 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPL47 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL47 36
  • 99 (a)
OneToOne
MRPL47 35
  • 99.6 (n)
  • 98.8 (a)
cow
(Bos Taurus)
Mammalia MRPL47 35
  • 85.75 (n)
  • 84.27 (a)
MRPL47 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPL47 36
  • 81 (a)
OneToOne
MRPL47 35
  • 87.6 (n)
  • 81.2 (a)
mouse
(Mus musculus)
Mammalia Mrpl47 36
  • 77 (a)
OneToOne
Mrpl47 16
Mrpl47 35
  • 80.8 (n)
  • 77.6 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPL47 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPL47 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl47 35
  • 79.73 (n)
  • 77.2 (a)
chicken
(Gallus gallus)
Aves MRPL47 35
  • 60.32 (n)
  • 55.87 (a)
MRPL47 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPL47 36
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5541 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl47 35
  • 60.87 (n)
  • 56.09 (a)
zebrafish
(Danio rerio)
Actinopterygii mrpl47 36
  • 50 (a)
OneToOne
idibd1090 35
LOC557789 35
  • 63.44 (n)
  • 62.37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002218 35
  • 47.73 (n)
  • 44.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rlc1 36
  • 30 (a)
OneToOne
mRpL47 35
  • 45.81 (n)
  • 41.23 (a)
worm
(Caenorhabditis elegans)
Secernentea mrpl-47 36
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.134 36
  • 43 (a)
OneToOne
Species with no ortholog for MRPL47:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL47 Gene

ENSEMBL:
Gene Tree for MRPL47 (if available)
TreeFam:
Gene Tree for MRPL47 (if available)

Paralogs for MRPL47 Gene

No data available for Paralogs for MRPL47 Gene

Variants for MRPL47 Gene

Sequence variations from dbSNP and Humsavar for MRPL47 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_052042 -
rs10513762 - 179,588,987(+) TCTCA(C/T)GTTCC reference, missense
rs1320221 -- 179,590,654(+) CTGTA(A/G)ACAAG intron-variant
rs3841961 -- 179,590,841(+) TCCTG(-/CAGATCCTG)GAGAC intron-variant
rs2879607 -- 179,592,112(+) ACAGG(A/C)ATGAG intron-variant

Variation tolerance for MRPL47 Gene

Residual Variation Intolerance Score: 64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.20; 76.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL47 Gene

HapMap Linkage Disequilibrium report
MRPL47

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MRPL47 Gene

Disorders for MRPL47 Gene

Relevant External Links for MRPL47

Genetic Association Database (GAD)
MRPL47
Human Genome Epidemiology (HuGE) Navigator
MRPL47
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL47

No disorders were found for MRPL47 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL47 Gene

Publications for MRPL47 Gene

  1. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 4 67
  2. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. GRSF1 regulates RNA processing in mitochondrial RNA granules. (PMID: 23473034) Jourdain A.A. … Martinou J.C. (Cell Metab. 2013) 3

Products for MRPL47 Gene

Sources for MRPL47 Gene

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