MRPL46 Gene
protein-coding GIFtS: 41
GCID: GC15M089002
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mitochondrial ribosomal protein L46(Previous name: chromosome 15 open reading frame 4 )
(Previous symbol: C15orf4)
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Aliases
for MRPL46 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Mitochondrial Ribosomal Protein L461 2 | | L46mt2 3 | | C15orf41 2 3 | | MRP-L462 3 | | LIECG21 2 3 | | Chromosome 15 Open Reading Frame 41 | | P2ECSL1 2 3 | | 39S Ribosomal Protein L46, Mitochondrial2 |
Export aliases for MRPL46 gene to outside databasesPrevious GC identifers: GC15P085369 GC15M082287 GC15M086589 GC15M086733 GC15M086734 GC15M086803 GC15M065114 |
Summaries
for MRPL46 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for MRPL46:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. Theyhave an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.(provided by RefSeq, Jul 2008)
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Genomic Views
for MRPL46 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010274.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MRPL46 gene promoter:
GR LHX3b/Lhx3b ISGF-3 p53 Brachyury GR-beta MyoD STAT5A LHX3a/Lhx3a GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for MRPL46
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL46 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q25.3 Ensembl cytogenetic band: 15q25.3 HGNC cytogenetic band: 15q25.3MRPL46 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M089002: view genomic region
(about GC identifiers)
Start:
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89,002,709 bp from pter |
End:
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89,054,752 bp from pter |
Size:
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52,044 bases |
Orientation:
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minus strand |
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Proteins
for MRPL46 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: RM46_HUMAN, Q9H2W6 (See
protein sequence)Recommended Name: 39S ribosomal protein L46, mitochondrial precursor Size: 279 amino acids; 31705 Da
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAG33698.1; Type=Erroneous initiation;
Secondary accessions: B2RD75 Q9HBU8Explore the universe of human proteins at neXtProt for MRPL46: NX_Q9H2W6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H2W6
MRPL46 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_071446.2
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
MRPL46 for ontologies About GeneDecksing
MRPL46 Antibody Products:
Assay Products for MRPL46: |
Protein
Domains /
Families
for MRPL46 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MRPL46 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H2W6ProtoNet protein and cluster: Q9H2W6 1 Blocks protein family: IPB000086 NUDIX hydrolase
UniProtKB/Swiss-Prot: RM46_HUMAN, Q9H2W6Similarity: Belongs to the ribosomal protein L46 family |
Function
for MRPL46 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL46 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL46
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: MRPL46 (NM_022163) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL46 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL46 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL46 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- | | GO:0016787 | hydrolase activity |
IEA | -- |
MRPL46 for ontologies About GeneDecksing
|
Pathways & Interactions
for MRPL46 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MRPL46
5/230 Interacting proteins for MRPL46 (Q9H2W62, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 230)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0008150 | biological_process |
ND | -- |
MRPL46 for ontologies About GeneDecksing
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Drugs & Compounds
for MRPL46 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for MRPL46
Search CenterWatch for drugs/clinical trials and news about MRPL46 / RM46
|
Transcripts
for MRPL46 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for MRPL46 gene: NM_022163.3 Unigene Cluster for MRPL46: Mitochondrial ribosomal protein L46 Hs.534261 [show with all ESTs]Unigene Representative Sequence: BI9134822 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000561140 ENST00000561832
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL46 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for MRPL46
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: MRPL46 (NM_022163) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for MRPL46 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL46 |
Additional cDNA sequence: AF205435.1 AF210056.1 AK315434.1 BC017883.1 8 DOTS entries: DT.416472 DT.86837468 DT.91819274 DT.95156450 DT.86835780 DT.100026629 DT.121018697 DT.92423382 24/254 AceView cDNA sequences (see all 254): BF356525 BM968277 AI469869 BE257656 BQ638709 BQ771640 AA128642 AK054603 BG574987 AI433200 BU617959 BQ005617 AI609699 AA683079 BU689327 CA418788 AL707845 BQ001942 AI056178 CA866497 AK125793 BU620038 AA322556 BQ010609
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MRPL46 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c |
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| SP1: | | | | | | | | | - | | | | - | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | | | |
| SP3: | | | | | - | | - | | - | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for MRPL46
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Expression
for MRPL46 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| MRPL46 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGGGTCAC
About this image
See MRPL46 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for MRPL46
SOURCE GeneReport for Unigene cluster: Hs.534261
SABiosciences Custom PCR Arrays for MRPL46
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for MRPL46
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat MRPL46 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL46 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL46 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL46 |
Orthologs
for MRPL46 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for MRPL46 gene from 5/10 species (see all 10) About this table
ENSEMBL Gene Tree for MRPL46 (if available)
TreeFam Gene Tree for MRPL46 (if available) |
Paralogs
for MRPL46 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for MRPL46 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for MRPL46 (89002709 - 89054752 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MRPL46: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for MRPL46 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 MRPL46 for disorders About MalaCards
MRPL46 for disorders About GeneDecksing
OMIM gene information: 611851
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: MRPL46 (2 documents)
Export disorders for MRPL46 gene to outside databases
|
Publications
for MRPL46 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for MRPL46 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with MRPL46) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, mapping and expression analysis of C15orf4, a novel human gene with homology to the yeast mitochondrial ribosomal protein Ym130 gene. (PubMed id 11761714)1, 2, 3 Carim-Todd L.... Escarceller M. (2001)
- The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PubMed id 11551941)1, 2, 3 Koc E.C....Spremulli L.L. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)
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External Searches for MRPL46 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing MRPL46 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MRPL46 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MRPL46 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for MRPL46 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for MRPL46 gene:
Search GeneIP for patents involving MRPL46
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MRPL46 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat MRPL46 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing MRPL46 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat MRPL46 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat MRPL46 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat MRPL46 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat MRPL46 |
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 | | | MRPL46 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for MRPL46 |
|  |  |  | | | | Search ThermoFisher Antibodies for MRPL46 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat MRPL46 |
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