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Aliases for MRPL46 Gene

Aliases for MRPL46 Gene

  • Mitochondrial Ribosomal Protein L46 2 3 5
  • C15orf4 3 4
  • MRP-L46 3 4
  • LIECG2 3 4
  • P2ECSL 3 4
  • L46mt 3 4
  • Chromosome 15 Open Reading Frame 4 2

External Ids for MRPL46 Gene

Previous HGNC Symbols for MRPL46 Gene

  • C15orf4

Previous GeneCards Identifiers for MRPL46 Gene

  • GC15P085369
  • GC15M082287
  • GC15M086589
  • GC15M086733
  • GC15M086734
  • GC15M086803
  • GC15M089002
  • GC15M065114

Summaries for MRPL46 Gene

Entrez Gene Summary for MRPL46 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL46 Gene

MRPL46 (Mitochondrial Ribosomal Protein L46) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation. GO annotations related to this gene include hydrolase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL46 Gene

Genomics for MRPL46 Gene

Regulatory Elements for MRPL46 Gene

Promoters for MRPL46 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MRPL46 on UCSC Golden Path with GeneCards custom track

Genomic Location for MRPL46 Gene

Chromosome:
15
Start:
88,459,476 bp from pter
End:
88,467,419 bp from pter
Size:
7,944 bases
Orientation:
Minus strand

Genomic View for MRPL46 Gene

Genes around MRPL46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPL46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPL46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL46 Gene

Proteins for MRPL46 Gene

  • Protein details for MRPL46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2W6-RM46_HUMAN
    Recommended name:
    39S ribosomal protein L46, mitochondrial
    Protein Accession:
    Q9H2W6
    Secondary Accessions:
    • B2RD75
    • Q9HBU8

    Protein attributes for MRPL46 Gene

    Size:
    279 amino acids
    Molecular mass:
    31705 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG33698.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL46 Gene

neXtProt entry for MRPL46 Gene

Proteomics data for MRPL46 Gene at MOPED

Post-translational modifications for MRPL46 Gene

  • Ubiquitination at Lys 132, Lys 203, and Lys 230
  • Modification sites at PhosphoSitePlus

Other Protein References for MRPL46 Gene

No data available for DME Specific Peptides for MRPL46 Gene

Domains & Families for MRPL46 Gene

Gene Families for MRPL46 Gene

Protein Domains for MRPL46 Gene

Suggested Antigen Peptide Sequences for MRPL46 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2W6

UniProtKB/Swiss-Prot:

RM46_HUMAN :
  • Belongs to the ribosomal protein L46 family.
Family:
  • Belongs to the ribosomal protein L46 family.
genes like me logo Genes that share domains with MRPL46: view

Function for MRPL46 Gene

Phenotypes for MRPL46 Gene

GenomeRNAi human phenotypes for MRPL46:
genes like me logo Genes that share phenotypes with MRPL46: view

Animal Model Products

miRNA for MRPL46 Gene

miRTarBase miRNAs that target MRPL46

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL46 Gene

Localization for MRPL46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL46 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPL46 Gene COMPARTMENTS Subcellular localization image for MRPL46 gene
Compartment Confidence
mitochondrion 5
nucleus 4

Gene Ontology (GO) - Cellular Components for MRPL46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IEA,IDA --
genes like me logo Genes that share ontologies with MRPL46: view

Pathways & Interactions for MRPL46 Gene

genes like me logo Genes that share pathways with MRPL46: view

Gene Ontology (GO) - Biological Process for MRPL46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPL46: view

No data available for SIGNOR curated interactions for MRPL46 Gene

Drugs & Compounds for MRPL46 Gene

No Compound Related Data Available

Transcripts for MRPL46 Gene

Unigene Clusters for MRPL46 Gene

Mitochondrial ribosomal protein L46:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL46 Gene

No ASD Table

Relevant External Links for MRPL46 Gene

GeneLoc Exon Structure for
MRPL46
ECgene alternative splicing isoforms for
MRPL46

Expression for MRPL46 Gene

mRNA expression in normal human tissues for MRPL46 Gene

Protein differential expression in normal tissues from HIPED for MRPL46 Gene

This gene is overexpressed in Pancreas (9.7) and Peripheral blood mononuclear cells (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL46 Gene



SOURCE GeneReport for Unigene cluster for MRPL46 Gene Hs.534261

genes like me logo Genes that share expression patterns with MRPL46: view

Protein tissue co-expression partners for MRPL46 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPL46 Gene

Orthologs for MRPL46 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPL46 35
  • 98.92 (n)
  • 98.57 (a)
MRPL46 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPL46 36
  • 78 (a)
OneToOne
MRPL46 35
  • 83.63 (n)
  • 80.14 (a)
dog
(Canis familiaris)
Mammalia MRPL46 35
  • 85.3 (n)
  • 85.3 (a)
MRPL46 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrpl46 16
Mrpl46 36
  • 80 (a)
OneToOne
Mrpl46 35
  • 82.73 (n)
  • 81.52 (a)
oppossum
(Monodelphis domestica)
Mammalia MRPL46 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrpl46 35
  • 81.83 (n)
  • 81.59 (a)
chicken
(Gallus gallus)
Aves MRPL46 36
  • 53 (a)
OneToOne
MRPL46 35
  • 63.05 (n)
  • 56.59 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5795 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl46 35
  • 63.89 (n)
  • 56.88 (a)
zebrafish
(Danio rerio)
Actinopterygii mrpl46 36
  • 44 (a)
OneToOne
mrpl46 35
  • 57.91 (n)
  • 49.58 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006684 35
  • 50.53 (n)
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL46 36
  • 34 (a)
OneToOne
mRpL46 35
  • 48.85 (n)
  • 38.87 (a)
worm
(Caenorhabditis elegans)
Secernentea mrpl-46 35
  • 43.9 (n)
  • 33.66 (a)
mrpl-46 36
  • 29 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPL17 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6462 36
  • 28 (a)
OneToOne
Species with no ortholog for MRPL46:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL46 Gene

ENSEMBL:
Gene Tree for MRPL46 (if available)
TreeFam:
Gene Tree for MRPL46 (if available)

Paralogs for MRPL46 Gene

(1) SIMAP similar genes for MRPL46 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MRPL46: view

No data available for Paralogs for MRPL46 Gene

Variants for MRPL46 Gene

Sequence variations from dbSNP and Humsavar for MRPL46 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
VAR_052046 -
rs6496486 -- 88,462,107(+) TTTAC(G/T)AGACA intron-variant
rs16941873 -- 88,460,328(+) GAAGG(A/T)CGAGG intron-variant
rs16941874 -- 88,460,330(+) AGGAC(A/G)AGGAC intron-variant
rs16941880 -- 88,463,466(+) ATGTA(C/T)TCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPL46 Gene

Variant ID Type Subtype PubMed ID
nsv904476 CNV Gain 21882294
nsv833085 CNV Gain+Loss 17160897

Variation tolerance for MRPL46 Gene

Residual Variation Intolerance Score: 67.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.56; 65.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL46 Gene

HapMap Linkage Disequilibrium report
MRPL46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL46 Gene

Disorders for MRPL46 Gene

Relevant External Links for MRPL46

Genetic Association Database (GAD)
MRPL46
Human Genome Epidemiology (HuGE) Navigator
MRPL46
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPL46

No disorders were found for MRPL46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL46 Gene

Publications for MRPL46 Gene

  1. Cloning, mapping and expression analysis of C15orf4, a novel human gene with homology to the yeast mitochondrial ribosomal protein Ym130 gene. (PMID: 11761714) Carim-Todd L. … Escarceller M. (DNA Seq. 2001) 2 3 4 67
  2. The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PMID: 11551941) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. (PMID: 25324306) Roy R. … Pardo O.E. (Nucleic Acids Res. 2014) 3

Products for MRPL46 Gene

Sources for MRPL46 Gene

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